A bi-annual update on the activities of UMIP, the University’sintellectual property management and commercialisation company

Issue 5, June 2011

UMIP - REPUTATION AND VALUE THROUGH INTELLECTUAL PROPERTY®

UMIP APPOINTS EMERGO GROUPAS REGULATOR-IN-RESIDENCE

UMIPNEWS

UMIP has appointed Emergo Group, a leading medical device consultancy, asRegulator-in-Residence. Emergo Group will provide regulatory support inrelation to the development and commercialisation of University researchprojects related to medical devices and diagnostics.

The University of Manchesterhas an extensive track record inbiomedical innovation and overthe past 18 months, EmergoGroup has been involved inproviding regulatory input for anumber of projects connected toUMIP, and in one case hasprovided a formal regulatoryopinion concerning an in-vitrodiagnostic test kit intended toscreen women at risk ofdeveloping cervical cancer.

Emergo Group senior consultant,Richard Love, will provideregulatory input via quarterlyclinics with UMIP’s biomedicalstaff. Input would includemedical device identificationand classification as well as the

key Regulatory and QualityManagement System (QMS)requirements in primary marketssuch as the EU, USA, Canada and Australia.

Richard commented: “We aredelighted to be associated withUMIP and this collaborationpresents an exciting opportunityfor Emergo Group. We lookforward to working with UMIPstaff and to providing keyregulatory support and guidanceas these early-stage device andIVD projects evolve intocommercial enterprises. Morethan 90% of our clients aresmall to medium size companiesso we understand their needsand challenges very well.”

Dr Rich Ferrie, Head of UMIPBiomedica, said that he wasdelighted that Emergo Grouphad agreed to accept theappointment. “We are verymuch looking forward toworking with Richard and theEmergo Group team. Theirextensive expertise will addsignificant value in shaping theregulatory landscape for ourearly-stage device anddiagnostics technologies and willoffer us a clearer vision of therequirements to take ourtechnologies and products to market.”

For more information about Emergo, visitwww.emergogroup.com

UMIC TO MERGE WITH UMIP

UMIC, the University’s businessincubation services provider, willbe merging with its sistercompany, UMIP, with effect fromthe 1st August 2011.

A new company will be formedto house a corporate servicesdivision which will supportUMIC’s and UMIP’s business unitswith services such as finance,legal and HR as well as sales,marketing and promotion.

This company will be called TheUniversity of Manchester I3

(I-cubed) which reflects theentrepreneurial spirit of UMIC’sand UMIP’s activities:Inspire/Invent/Innovate.

Both the UMIC and UMIP brandswill remain, with UMICcontinuing to provide world-class business incubationfacilities for University spin-outcompanies, with added emphasison its role as a true InnovationCentre, and UMIP to provide

intellectual propertycommercialisation activities onbehalf of the University. Since the creation of the ‘new’University in 2004, both UMICand UMIP have worked side byside to ensure the seamlesstransition of academicinnovation from idea tomarketplace either via spin-out creation or licence tothird parties and haveestablished a well-regardedinternational reputation forUniversity innovation.

Richard Love, Emergo Group senior consultant

Core Technology Facility...part of the Innovation Centre

INTELLECTUALPROPERTYRESOURCE

An intranet resource for:

> Understanding IP

> IP Commercialisation

> IP in Research and Consultancy

> IP & Academic Materials

UMIP’s Commercialisation Executives are your first point of callfor any questions you may have should you have an idea orobservation and are wondering if it has potential value.

Our Commercialisation Executives are faculty specific:

MEET YOUR UMIP FRONTLINE CONTACTS

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If you are working on research that you think has commercialpotential, we would be pleased to hear from you.

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eThe companies in our portfolio, excepting onecompany that has fully exited, are still goingstrong and are making good commercialprogress. All of them are recent start-upcompanies commercialising rich IP and manynow have customers. Customers are the bestform of finance any company can secure andare the ultimate validation of the utility of the science.

Among the currently most promisingcompanies in the portfolio is Arvia, a spin-outfrom the School of Chemical Engineering.Arvia has destroyed its first batch ofradioactive oil at Magnox's Trawsfynydd PowerStation. Radioactive oil waste is currentlyimpossible to treat in volume and can only bestored at present. Bioxydyn (spin-out from theSchool of Medicine) has also secured a contractwith a major pharmaceutical company for lungMRI imaging services to support clinical trials.

As these companies gain momentum theirteams and operations need to expand toservice increasing customer interest. Often thisexpansion is required in advance of substantialsales revenue and as a consequence theseyoung companies require significant sums offurther investment. In most cases the UPF willcollaborate with other investment groups tosyndicate the necessary investment required tofund the companies properly, in the region ofseveral million pounds per company. Securingthis additional investment in the current

economic climate is very tricky and is probablythe major challenge for the UPF in 2011.Early indications are positive but I don’t wantto say anything more at this time for the riskof tempting fate…

In addition, the UPF has also supported 17Proof-of-Principle (PoP) projects in three yearssince the fund launch. These projects areessential for the development of a commercialplan around University IP and can be used tosupport commercially relevant technical workin the University as well as non-technicalactivities supporting business development.The UPF is open for business for additionalnew PoP projects and if you have an ideaplease contact UMIP.

UMIP PREMIER FUND UPDATE...

Mark RahnInvestment ManagerMTI Partners (Managers of the UMIP Premier Fund)

www.theupf.com

For Technology and Humanities:

Dr Pushkar Wadke, EPST: 0161 306 8832E: pushkar.wadke@umip.com

Dr Lorna Farnsworth, EPST: 0161 306 8813E: lorna.farnsworth@umip.com

Dr Mugdha Joshi, EPST: 0161 306 8513E: mugdha.joshi@umip.com

Daniel Syder, HumanitiesT: 0161 306 8512E: daniel.syder@umip.com

For Life Sciences and Medical &Human Sciences:

Dr Arnaud Garçon, FLS/MHST: 0161 603 7757E: arnaud.garcon@umip.com

Dr Edward Maughfling, MHST: 0161 606 7213E: edward.maughfling@umip.com

Dr Gill Shuttleworth, FLST: 0161 603 7738E: gillian.shuttleworth@umip.com

OUR SEED FUND RUNNING SINCE MARCH 2008

BIOXYDYN - ADVANCED MEDICAL IMAGING

VRGS - SOFTWARE FOR GEOLOGICAL APPLICATIONS

LATEST LICENSING & SPIN-OUT NEWS

BiOxyDyn was spun out of theImaging Sciences ResearchGroup, School of Cancer andEnabling Sciences within theFaculty of Medical and HumanSciences in 2010 and is based onresearch undertaken byProfessor Geoff Parker and hisresearch group. The spin-out hasreceived commercialisationsupport and advice from UMIPand both Proof-of-Principle andadditional funding from TheUMIP Premier Fund (UPF).

BiOxyDyn’s technology centreson an unique, non-invasivemagnetic imaging (MRI) toolwhich has the potential toconsiderably improve thetreatment of lung conditionssuch as chronic obstructivepulmonary disease (COPD),asthma, cystic fibrosis andemphasema as well as aiding cancer specialists and neuroscientists.

COPD is the world’s 3rd biggestkiller but Bioxydyn’s diagnosticimaging technologies have thepotential to change the way inwhich lung disease is diagnosedand monitored by providingnon-invasive regionalassessments of lungventilation/perfusion ratio (V/Q)and measures of changes inpulmonary vascular function.

Bioxydyn is also developingpowerful MRI based oncologytools for quantifying tumouroxygenation and oxygenmetabolism. By providingunique non-invasivecharacterisation of theoxygenation status of tumours

its technologies will aidtherapeutic decision making andprovide additional informationfor assessing the response oftumours to intervention.

Commenting on the potentialfor this new technologyProfessor Geoff Parker, BioxydynDirector said: “There currentlysimply isn't an inexpensive orpractical 3D lung imagingtechnique available that cancapture the structure andfunction of the lung, so we feelwe've got something the marketwill want quickly. Lung diseasesand disorders are socommonplace, with COPDaffecting 80M people andcausing 3M deaths world-wideeach year.” He continues:“We've some exciting interestfrom major pharmaceuticalplayers, so the race is on todevelop our products andengage with the market tobring this to a commercialreality as soon as possible.”

Professor Geoff Parker who isalso Director of The University of Manchester’s Biomedical

Imaging Institute, has beennamed by the Institute of PublicPolicy Research as one of 50'Northern Lights' in recognitionof his work with BiOxyDyn.

In 2010 BiOxyDyn was named asStartup of the Year at theNorthwest Biomedical Awards.

Remember to discuss possible IP protection before you publish. Contact your UMIP Commercialisation Executive first.3

UMIP has assisted Dr DaveHodgetts from the Basin Studiesand Petroleum Geoscience Groupwithin The School of Earth,Atmospheric and EnvironmentalSciences, to license his latestprocessing software for PCs,which enables the interpretationof geological outcrops.

Dr Hodgetts' research group hasdeveloped a novel means of 3Dinterpretation and mapping

geological structures, using lightdetection and range technology(LiDAR). The resulting data is ofgreat importance in thePetroleum industry to helpunderstand and improveproduction from hydrocarbon reservoirs.

At the centre of Dr Hodgetts’research is the development ofsoftware called Virtual RealityGeological Studio (VRGS) which

is specifically designed forgeological applications. VRGS isa Windows based application,which allows the manipulation,interpretation and analysis ofLiDAR data in a way that ismeaningful to a geologist.Though initially developed tosolve Oil and Gas productionissues, the software is now beingdeveloped to address the needsof geologists in other nonpetroleum sectors such as geo-conservation.

A LiDAR scanner collects up to12,000 points of data in asecond, creating a 3D image of astructure such as a cave, cliff orrock formation. This data is thencollated and analysed by theunique software which DrHodgetts has created. It iscapable of analysing the results at a far greater level of detail than has previouslybeen possible.

Commenting on the successfullicencing of the technology, Dr Hodgetts said: “The scanningtechnology itself is not especially

novel but the means ofanalysing the data certainly isand we have received interestaround the world from other universities, geo-conservationalists andpetroleum companies. It canprovide a complete picture of astructure in intricate detailwhich is invaluable forhydrocarbon production, drillingand mining.”

The software has already beenlicensed to universities in the UKand Spain, and a further licenceis being finalised in Scandinavia.These techniques are beingapplied in several projects,ranging from modeling ofMiocene deposits in Sinai,mapping Triassic fluvialsediments in Morocco andCanada as well as the improvedanalysis and archiving ofdinosaur track ways in Spain.

The technology was shownrecently on NationalGeographic's Dino Autopsyprogramme, and on Channel 4as The Dinosaur Mummy.

www.bioxydyn.com

Prof. Geoff Parker

DARE TO BE DIFFERENT

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In late 2010, Dr Gill Green, MDof STORM® , scooped a ‘Dare tobe Different’ Award from the HESocial Entrepreneurship Awardsprogramme from UnLtd and theHigher Education FundingCouncil for England (HEFCE).UnLtd is a charity whichsupports social entrepreneurs byproviding a complete package offunding and support, to helpthese individuals make theirideas a reality.

Gill was awarded £15,000 andwill also receive business supportand mentorship from UnLtd fora year. The money will helptowards the start up of STORM®

as a community interestcompany (CIC).

Gill comments: “We aredelighted to have beensuccessful. This is a prestigiousaward and we were up againststiff competition. Although themoney will help us to set up the

Social Enterprise we have beenworking towards, it is therecognition for STORM® and itscontribution to the communitythat is the greatest reward.”

STORM®’s training packages helpfrontline staff in health andsocial care spot the signs ofsuicidal tendencies and self-injury. The training packages areused across a range of adult andchildren’s services includingprimary care, A&E departments,third sector services and schools.A new Higher Educationpackage, which consists of twoproducts: Occupational Health(for OH staff) and HigherEducation (for staff workingwith students) is currently beingpiloted. The University will beone of the first customers.

The STORM® model has beenembraced by UK governments aspart of their suicide preventionstrategies. Attempting to reducethe suicide rate is important; theWorld Health Organisationestimates that one person willdie by suicide every 40 secondsworldwide. To date there hasbeen little skills training insuicide prevention provided to

healthcare profesisonals in theUK whose interventions couldmake the difference betweenlife and death.

Gill explains: “In my work as aclinician and now as aresearcher, I have seen a realgap in the market and a needfor flexible skills-based trainingpackages in suicide prevention.Training is key if we are to havea responsive workforce that canpositively and effectively helppeople in distress and thinkingof ending their lives.”

STORM® continues to evolvethrough ongoing research, withcustomer feedback helping toimprove the product and toidentify additional markets.

Explains Gill: “Through a processof continual customer feedbackwe discovered that there was afurther need for a trainingproduct that deals with selfinjury, therefore we haveaddressed this with theproduction of an additionalSTORM® product dealingspecifically with this issue.”

Dr Martin Henery, HEFCE SocialEnterprise Ambassador for theUniversity felt that Gill’s successin gaining one of the covetedUnLtd HEFCE awards was fullydeserved given both thestrength of the business caseand the value of their socialmission. In fact the Universityhas enjoyed above averagesuccess with another 5 studentrun social enterprises accessing afurther £20k in awards fromUnLtd. Martin commented:“These awards just reflect thestrong desire and abilities ofboth students and staff fromthis University to createsustainable solutions to some ofthe bigger social problems thatcurrently face us.”

For more information aboutSTORM® visit their new websiteat www.stormskillstraining.com

UMIP/MIMIT DESIGNER-IN-RESIDENCE –ONE YEAR ON…

I never really knew what toexpect when appointed asDesigner-in-Residence for UMIPand MIMIT (Manchester:Integrating Medicine andInnovative Technology). It is nowa year since the start of thisprogramme and probably whathas excited me the most aboutthis role is the breadth oftechnologies that both theirteams are dealing with.I have had some fascinatingmeetings with different groupsworking on amazing science and

the one certainty I now have isthat every project will belooking for very different inputsand experience from myself.Perhaps I had expected that thecommon skills such as,development planning, userinterface and proof-of-principleexperience would form commonthreads in my conversations withdifferent research groups.Rather excitingly this has notproved to be the case andunexpected interventions suchas introducing potential fundingpartners and Maddison clientsfrom the corporate world haveformed part of my input.

We have recently initiated aseries of lunchtime discussions onsubjects of interest to UMIP andMIMIT. The first of these was byMike Addison, Section Head R&Dat Procter & Gamble who talkedabout their open innovationprogramme and theengagement process. AlthoughP&G’s areas of activity areperhaps not mainstream forManchester, I think the principlesof engaging with corporatecompanies was well received andwe are planning more to follow.

So far only two of the projectswe have worked on areavailable for discussion due tothe obvious confidential natureof most projects. Firstly, Dr PaulMalone’s very clever device tohelp steady and position thearm and wrist during MRI scans.We have worked with Paul andDr Arnaud Garçon, UMIP’scommercialisation executive forFLS and MHS, to bring the design

up to a manufacturingspecification and providecostings and visualisations forlicensing discussions. Another,and perhaps in some ways morechallenging, project has beenworking with MIMIT on solutionsto various problems associatedwith colostomy. This work is stillongoing but has produced someexciting possibilities.

By David Maddison, Maddison Ltd

Imaging jig for upper limb

Dr Gill Green

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A Guide to UMIP

Case Studiesof Licensing

Case Studiesof Spin-outs

IP & Confidentiality

Spin-out Companies

Licensing

Consulting

ResearchContracts

IP Workbook

Academic Materialsand Publishing

Download thefollowingguides andbooklets fromwww.umip.com

Hard copies available from:sarah.harris@umip.com

5 Years of UMIP

One of the significant added value aspects intechnology transfer which attracts seedfunders and licensees is Proof-of-Principleinvestment funding.

To add value, UMIP manages, for theUniversity, a ‘Proof-of-Principle’ account forprojects with good potential. We encourageyou to find out more and make an application.Applications are reviewed throughout the year.

To find out more, please contact your UMIPcommercialisation executive listed on thesecond page of this newsletter.

To illustrate the diversity of projects awardedsince October 2010, please see below:

Dr Suresh Victor (School of Biomedicine) andProf Patrick Gaydecki (School of Electrical andElectronic Engineering)Software for the automatic analysis of brainelectrical activity in premature newborn babies> Licensing PoP awarded January 2011

Prof. Mark Boyett & Dr. Halina Dobrzynski(School of Biomedicine, Faculty of Medical andHuman Sciences) and Prof. Henggui Zhang(School of Physics & Astronomy, Faculty ofEngineering and Physical Sciences).Mathematical model of the human heart>Licensing PoP awarded February 2011

Dr Alan Brisdon - School of Chemistry, Facultyof Engineering and Physical Sciences, ProfKonstantin Novoselov - School of Physics,

Faculty of Engineering and Physical SciencesFluorographene and 2D Fluropolymers>Spin-out / Licensing PoP awarded March 2011

Dr. Ian Kinloch, Prof. Robert Young - School ofMaterials, Faculty of Engineering and PhysicalSciences, Prof Robert Dryfe, Prof MichaelTurner - School of Chemistry, Faculty ofEngineering and Physical SciencesScalable Routes For Graphene Production> Spin-out / Licensing PoP awarded March 2011

Professor Jian Lu - School of Physics andAstronomy, Faculty of Engineering andPhysical SciencesThermo-responsive cell culture surfaces> Licensing PoP awarded October 2010

Drs Clare O’Donnell and Hema Radhakrishnan- Eye and Vision Science Centre, Faculty of Life SciencesMethod of processing eye aberrationmeasurements for keratoconic lens manufacture> Licensing PoP awarded January 2011

Dr Curtis Dobson - Faculty of Life SciencesMicroSensor> Spinout PoP awarded April 2011

Dr. Chris Rose - School of Cancer and Enabling Sciences, Faculty of Medical andHuman SciencesSparse Parametric Imaging> Licensing PoP awarded November 2010

UMIP PROOF-OF-PRINCIPLE (PoP)INVESTMENT SCHEME

We met with Dr Bill Crowther from the School of Mechanical Aerospace and CivilEngineering to find out more about how UMIP Proof-of-Principle funding has helped himto exploit the commercial potential of the innovative miniature pump technology his team is developing.

Bill began developing the technology, with theaerospace industry in mind, for producing smallair jets to control the flow over wings.However, with help and advice from UMIP, thesame principle is now being developed as ageneral technology for pumping both liquidsand gases for non aerospace applications. Billexplains: “Our research group had beenworking closely with Airbus and BAE Systems todevelop flow control actuators. It wasn't untilwe started working with our commercialmentor, Geoff Butcher, whose background cutsacross the engineering sector that we realisedthere was also a huge potential for widerapplication, such as in pumping liquids forvarious medical applications.

UMIP introduced us to Geoff who has assessedthe technology and its potential for commercialapplications and has encouraged us to exploreother uses which we would otherwise not have considered.

We have received really helpful and strategicadvice from Geoff and UMIP which has certainlyfocused our thinking. UMIP quickly secured theIP on our technology and put forward anexternal expert who has really challenged ourthinking and introduced us to potential new markets.”

Bill continues: “The market for pumps such asthis is extremely diverse so we know there arelots of potential uses in sectors such asbiomedical, gas sensing and electronics and weare working on getting the appropriateprototypes made.

The funding we have received from the UMIPProof-of-Principle Fund has been invaluable andwill enable us to get to the stage where we cancost out the production. Now we are in theposition to test out the mathematical modeland to discover what companies’ requirementsare so we can refine it to meet their needs.

I would certainly urge others to seek the adviceof UMIP sooner rather than later, as they canreally help you explore commercialopportunities of your research work early on.Ultimately, if there is commercial potential, youcan get going in the right direction at thebeginning of the project, which saves a greatdeal of time further down the line.”

Please see our IP Awareness Resource atwww.manchester.ac.uk/ipresourcefor a valuable insight into the types of IP whichcan be used to protect novel ideas/inventionsalong with a series of guides and bookletswhich you may find useful.

PROOF OF PRINCIPLE FUNDING CASE STUDY:

AN INTERVIEW WITH DR BILL CROWTHER

Core Technology Facility46 Grafton Street

Manchester M13 9NTT: 0161 603 7751info@umip.comwww.umip.com

UMIP®The University of Manchester’s Intellectual

Property Commercialisation Company

NORTH WEST CLEAN TECH COMPANY NUCLEAR PIONEERS

BEHIND THE SCENES

In this column, we will be takinga look behind the scenes tomeet some of our UMIP supportstaff. Sarah Harris is MarketingAssistant with the CorporateCommunications, PR and Media Team.

Having been with the companyfor 11 years, Sarah hasexperience working in a varietyof roles and took up her currentposition upon returning frommaternity leave 5 years ago.

“A lot of my time is spentworking with our marketingmanager, Allan Prits, inincreasing the awareness ofUMIP throughout the University.One of my main remits is todiscover ways of getting ourmessage across to the manyresearch groups by distributingour Researchers’ Guides,

additional promotionalliterature, producing posters fordisplay, promoting competitionsand also arranging events forUMIP to attend.

Our online Intellectual PropertyResource is proving to bepopular with staff. Since wehave been using innovative waysof promoting it campus-wide,we have seen a notable increasein visitors.”

Sarah added: “I enjoy how myrole enables me to interact witha variety of people, both within

UMIP itself and the University. It has helped me gain a betterunderstanding of the companyand also the range of other roles and tasks.”

It is evident that Sarah is full ofenthusiasm, stating: “After 11years, I still gain a great sense of achievement from my role and it has been fantastic towatch the development over the years. I am particularlylooking forward todevelopments in UMI3.”

Printed on recycled paper

© The University of Manchester Intellectual Property Ltd 2011

Since our last issue of UMIPNews, UMIC and UMIP havereceived three governmentvisits. On Wednesday 20th April,Alan Lewis CBE, theConservatives’ Vice Chairman forBusiness Relations visited todiscover how universities areworking with businesses togenerate growth for the UKeconomy. He was particularlyinterested in meeting a selection

of spin-out companies from theUniversity and local entrepreneursto gain a clearer understandingof the issues which affect themin today’s economic climate.

Welcomed by Professor RodCoombs, Deputy President, andPeter Fell, Director of Regionaland Economic Affairs, AlanLewis took part in a roundtablediscussion with 6 start-up

companies associated with UMICand UMIP. Mr Lewis has sincewritten to say he plans to visit again and assist theUniversity in developing its entrepreneurial networks.

In January this year, ChiOnwurah, the Shadow Ministerfor Innovation & Science(Business, Innovation and SkillsTeam) and MP for NewcastleUpon Tyne Central, visited.

Having discussed education,innovation and enterprise withProfessor Rod Coombs and CliveRowland, CEO of UMIP, Ms Onwurah commented:“Innovation is the engine ofgrowth and progress. I wasimpressed by the work UMIP isdoing to commercialiseinnovation and help us keep ourplace at the forefront of world

science. Universities, small localbusinesses, global companiesand financiers all need to beable to work together to crossfertilise ideas, enable innovationand growth. I hope UMIP cancontinue to work with allstakeholders in this way.”

In October last year, The Rt HonVince Cable, Secretary of Statefor Business, Innovation andSkills, visited UMIC.

Dr Cable was given a tour of theworld-class business incubationresources in the Core TechnologyFacility. During the tour, Dr Cablediscovered how the Universityidentifies and supports innovativeresearch commercialisationpotential, nurtures and developsspin-out companies and licenses technology.

GOVERNMENT VISITS TO UMIC AND UMIP

Arvia Technology and Magnox Ltd scoop majorenvironmental award

In January, North West basedwater and waste treatmentspecialists Arvia Technology Ltd,and Nuclear operators MagnoxLtd, scooped a prestigiousRushlight clean technology awardat one of the UK and Ireland’spremier environmental events.

The companies jointly walkedaway with the coveted RushlightClean Environment Award, inrecognition of their partnershipin developing the Arvia Titan, anew and highly innovative

solution for the treatment ofradioactive oil waste. Retrievingand processing this type ofwaste material is a majorchallenge, as part ofdecommissioning and cleaning-up the UK’s nuclear legacy.

Arvia Technology, a spin-outfrom The University ofManchester which started life asa Proof-of-Principle investment, developed new low carbon,waste and chemical freetechnology for the treatment of

water and waste water.However, innovativecollaboration with nuclearspecialists Magnox Ltd revealeda new and high-value,sustainable solution.

www.arviatechnology.com

Alan Lewis, CBE and Clive Rowland, UMIP CEO

STOP PRESS... Arago Technology voted the UK’s most promising spin-out by business magazine, Real Business