Meeting Venue:Hilary J Boone Center

500 Rose Street, University of KentuckyLexington, KY 40506 – 0014

Agenda Day 1 – October 4, 2017

8:00-8:30 Registration and Continental BreakfastWelcome and Introduction to the workshop, state of the field and overview of the issues and challenges in translational stroke research.

8:30 - 9:15 Introduction: Leveling the playing field: Update on the current clinical paradigm in stroke and identification of opportunities for translational research. William Mack

1. Epidemiology of stroke2. Stroke Systems of Care3. tPA and Thrombectomy4. ICH5. SAH and Vasospasm

9:15 – 10:15 Didactic Session 1: Animal models – The Stroke Researcher’s Workhorse. S. Tom Carmichael and Miguel Perez-Pinzon

1. STAIR recommendations as a working foundation for current and future research.2. Identifying barriers to translation in animal model research: Should we start from the diseased animal?3. Negative data: Don’t be afraid to publish the negative!4. Impact of neuroprotection versus neurorepair focus on animal model choice5. Relevance of behavioral models to the human condition

10:15 - 10:30 Coffee Break

10:30 – 11:45 Didactic Session 2: Animal Models Part II – Diamonds in the rough. Halina Offner and Lauren Sansing1. Positive translations from prior stroke studies:

tPA, aneurysm treatments, CLEAR trial.2. The potential need for preclinical studies to reflect clinical trials.3. Reverse translation: creating better animal models from human data.

11:45 – 13:00 Lunchtime Roundtables: Lunch is served with clinicians and basic scientists: How to develop clinician-basic researcher partnerships for seamless transition from bench to bedside. Tables will be assigned topics for discussion (ischemic stroke, ICH, etc. based on the specialties and research interests of the attendants). Gregory Bix, Keith Pennypacker, Justin Fraser

Throughout the day, select exhibitors will be available in private tech suites for a R&D review. During this time, industry partners may present new research, developing technology, or plans for clinical or translational studies and receive feedback and questions in a one-on-one format.

Afternoon Destination Activity:

14:15-16:15 Buffalo Trace Distillery Tour and Tasting

16:45-18:45 Dinner and wine tasting at Equus Run Winery and Vineyard

19:30 Return to Boone Center and Hotel 21c

Day 2 – October 5, 2017

08:00 – 08:30 Continental Breakfast

08:30 – 10:00 Didactic Session 3: Grantsmanship for Translational Research Francesca Bosetti1. What are the funding priorities for the NIH in translational stroke research?2. What are the best mechanisms for individual stroke researchers and stroke research centers?3. How do translational projects get funded – co-PIs? Mixing clinical and basic aims?

10:00 – 10:15 Coffee Break

10:15 – 11:30 Facilitated Speaker Panel Discussion Lauren Sansing, William Mack, Halina Offner, Francesca Bosetti, Cenk Ayata (facilitator).Questions for discussion:

1. How do I get my drug from animals to humans?2. Tips for collaboration: Joint lab meetings, Clinical Shadowing, Translational Research Grants, dual-mentorship

for trainees3. Branching out of your ‘meeting’ comfort zone: Attending stroke meetings on the other ‘side’

11:30 – 12:30 Lunchtime Roundtables: Lunch is served with attendance by clinicians, basic scientists, and industry, with tables organized around topics (ischemic stroke, intracranial hemorrhage, aneurysms and subarachnoid hemorrhage). Gregory Bix, Keith Pennypacker, Justin Fraser

12:30 Adjournment