UC Resources for Research Support

Douglas S. Bell, MD, PhD Leader, UCLA CTSI Biomedical Informatics Program

UCLA CTSI Biomedical Informatics Program

Overview  

•  Cohort  size  es.ma.on  – UC-­‐ReX,  LADR  

•  Data  collec.on  and  data  set  management  – REDCap  

•  EHR  data  access  – Recruitment  – Clinical  data  export  

•  “Big”  data  

UC  Research  eXchange  (UC-­‐ReX)  

•  Trials  oIen  fail  to  meet  recruitment  targets  – Technology  is  needed  to  find  eligible  pa.ents  

•  UC  Health  System  – 5  AMCs,  10  hospitals  – 144,000  admissions,  290,000  ER  visits  /  year  – 3.9  million  ambulatory  visits  /  year  – 50%  of  all  transplants  in  California  

•  UC-­‐ReX  Vision  Enable  researchers  to  query  clinical  data  from  all  UC  Health  campuses  under  a  cross-­‐ins:tu:onal  IRB  approval  process  

UC-­‐Rex:  Federated  Data  Architecture  

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ETL  

Data  Warehouse  

SHRINE  

UCLA  

ETL  

Data  Warehouse  

SHRINE  

UCI  

ETL  

Data  Warehouse  

SHRINE  

UCSD  

ETL  

Data  Warehouse  

SHRINE  

UCD  

ETL  

Data  Warehouse  

SHRINE  

UCSF  

ucrex.ctsi.ucla.edu

UC-ReX Demo

Aim 2: Research Data Repository

•  UC-ReX Data –  Demographics (age, gender, race/ethnicity, language, religion) –  ICD-9 diagnoses and procedures –  Top 100 lab tests –  Medications (outpatient orders + inpatient med administration)

Site     DISTINCT  PATIENTS    

TOTAL  OBSERVATIONS      

DEMO-­‐GRAPHICS      

DIAGNOSES       PROCEDURES      LAB  RESULTS       VITAL  STATUS      

MedicaAons      

UCSD       2,226,393   82,610,531   6,891,004   10,614,282   0   65,033,266   4,396      

UCI       1,502,637   52,651,819   10,332,268   21,240,149   858,073   18,733,969   2,904      

UCSF       1,898,967   85,624,811   1,807,854   5,860,213   285,067   77,615,742   34,568   21,367  

UCD       2,001,452   109,871,655   10,921,320   18,958,851   680,524   79,120,530   35,780      

UCLA       4,203,760   175,221,156   29,630,790   28,146,462   1,263,310   107,273,014   42,810   8,864,770  

Total     11,833,209   505,979,972   59,583,236   84,819,957   3,086,974   347,776,521   120,458      

Los Angeles Data Resource (LADR)

    DisAnct  PaAents   Total  Facts  

Cedars   2,424,482   19,468,005  

UCLA   4,180,722    67,507,617  

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Getting Patient-level Data

•  Obtain IRB approval (Human subjects)

•  Obtain Compliance approval (security and privacy)

•  Set up location for receiving the data

•  Data transfer to secure database or file server

•  REDCap

xDR  Data  Warehouse  

EHR Import Module Eligible  paAents  

Clinical  labs  

“Big”  Data  Plaaorms  

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“Big”  Data  Plaaorms  

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