Tumor markers ppt BIOCHEMISTRY
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Transcript of Tumor markers ppt BIOCHEMISTRY
![Page 1: Tumor markers ppt BIOCHEMISTRY](https://reader033.fdocuments.net/reader033/viewer/2022061511/554b18f6b4c90569098b4ee8/html5/thumbnails/1.jpg)
Tumor markersDr Vijay Marakala M.D
BIOCHEMISTRYSIMS &RC
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TUMOR MARKERS
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OUTLINE
Definition Clinical uses
Classification Examples
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TUMOR MARKERS
Substance found in increased amounts in the blood, other body fluids and tissues that
may suggest the presence of cancer
Definition
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CLINICAL APPLICATIONS OF TUMOUR MARKERS
Diagnosis Prognosis Monitor treatment
Detection of
recurrenceScreening
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CLASSIFICATION OF TUMOUR MARKERS
Hormones Oncofetal Antigens
Enzymes Tumor-
Associated Proteins
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TUMOR MARKERS - Hormones
Human chorionicgonadotropin
• Gestational trophoblastic disease
• Gonadal germ cell tumor
Calcitonin
• Medullary cancer of the thyroid
Catecholamines
• Pheochromocytoma
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TUMOR MARKERS – Oncofetal antigens
• Hepatocellular carcinoma,
• Gonadal germ cell tumor
α-Fetoprotein
• Adenocarcinomas of the colon, pancreas, lung, breast, ovary
Carcinoembryonicantigen
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TUMOR MARKERS - Enzymes
• Prostate cancerProstatic acidphosphatase
• Small cell cancer of the lung,• Neuroblastoma
Neuron-specificenolase
• Lymphoma, • Ewing's sarcoma
Lactatedehydrogenase
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TUMOR MARKERS - Tumor-Associated Proteins
Prostate-specific antigen
Prostate cancer
Monoclonal immunoglobulin
Myeloma
CA-125
Ovarian cancer
CA19-9
Colon, pancreatic,
breast cancer
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COMMONLY USED TUMOR MARKERS
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The crucial link between anatomy and molecular pathways
From anatomy… via serological tumor markers … to molecular pathways
Lung KIT
Breast EGFR
ProstateHER2
Colon BRAF
BrainPIK3CA