TRYPTOPHAN METABOLISM Lecture 5... · 2020. 1. 27. · Tryptophan metabolism Tryptophan ron...

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TRYPTOPHAN METABOLISM

Transcript of TRYPTOPHAN METABOLISM Lecture 5... · 2020. 1. 27. · Tryptophan metabolism Tryptophan ron...

Page 1: TRYPTOPHAN METABOLISM Lecture 5... · 2020. 1. 27. · Tryptophan metabolism Tryptophan ron deficiency leads to block this reaction Vit Liver enzyme Tryptophan dioxygenase Other tissue

TRYPTOPHAN METABOLISM

Page 2: TRYPTOPHAN METABOLISM Lecture 5... · 2020. 1. 27. · Tryptophan metabolism Tryptophan ron deficiency leads to block this reaction Vit Liver enzyme Tryptophan dioxygenase Other tissue
Page 3: TRYPTOPHAN METABOLISM Lecture 5... · 2020. 1. 27. · Tryptophan metabolism Tryptophan ron deficiency leads to block this reaction Vit Liver enzyme Tryptophan dioxygenase Other tissue

TRYPTOPHAN Metabolism (W)

Page 4: TRYPTOPHAN METABOLISM Lecture 5... · 2020. 1. 27. · Tryptophan metabolism Tryptophan ron deficiency leads to block this reaction Vit Liver enzyme Tryptophan dioxygenase Other tissue

• This amino acid is both glucogenic and ketogenic because its metabolism yields alanine and

acetoacetyl CoA.

• 11 Carbon catabolized as

•Formyl group (1Cone

carbon pool)

• Alanine (3C CHO)

• Acetoacetate (4C

Ketogenic)

• 3 C CO2

Page 5: TRYPTOPHAN METABOLISM Lecture 5... · 2020. 1. 27. · Tryptophan metabolism Tryptophan ron deficiency leads to block this reaction Vit Liver enzyme Tryptophan dioxygenase Other tissue
Page 6: TRYPTOPHAN METABOLISM Lecture 5... · 2020. 1. 27. · Tryptophan metabolism Tryptophan ron deficiency leads to block this reaction Vit Liver enzyme Tryptophan dioxygenase Other tissue
Page 7: TRYPTOPHAN METABOLISM Lecture 5... · 2020. 1. 27. · Tryptophan metabolism Tryptophan ron deficiency leads to block this reaction Vit Liver enzyme Tryptophan dioxygenase Other tissue
Page 8: TRYPTOPHAN METABOLISM Lecture 5... · 2020. 1. 27. · Tryptophan metabolism Tryptophan ron deficiency leads to block this reaction Vit Liver enzyme Tryptophan dioxygenase Other tissue
Page 9: TRYPTOPHAN METABOLISM Lecture 5... · 2020. 1. 27. · Tryptophan metabolism Tryptophan ron deficiency leads to block this reaction Vit Liver enzyme Tryptophan dioxygenase Other tissue
Page 10: TRYPTOPHAN METABOLISM Lecture 5... · 2020. 1. 27. · Tryptophan metabolism Tryptophan ron deficiency leads to block this reaction Vit Liver enzyme Tryptophan dioxygenase Other tissue
Page 11: TRYPTOPHAN METABOLISM Lecture 5... · 2020. 1. 27. · Tryptophan metabolism Tryptophan ron deficiency leads to block this reaction Vit Liver enzyme Tryptophan dioxygenase Other tissue
Page 12: TRYPTOPHAN METABOLISM Lecture 5... · 2020. 1. 27. · Tryptophan metabolism Tryptophan ron deficiency leads to block this reaction Vit Liver enzyme Tryptophan dioxygenase Other tissue
Page 13: TRYPTOPHAN METABOLISM Lecture 5... · 2020. 1. 27. · Tryptophan metabolism Tryptophan ron deficiency leads to block this reaction Vit Liver enzyme Tryptophan dioxygenase Other tissue
Page 14: TRYPTOPHAN METABOLISM Lecture 5... · 2020. 1. 27. · Tryptophan metabolism Tryptophan ron deficiency leads to block this reaction Vit Liver enzyme Tryptophan dioxygenase Other tissue
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Page 17: TRYPTOPHAN METABOLISM Lecture 5... · 2020. 1. 27. · Tryptophan metabolism Tryptophan ron deficiency leads to block this reaction Vit Liver enzyme Tryptophan dioxygenase Other tissue
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Modulation of Tryptophan Metabolism, Promotion of ...Abstract: Although tryptophan (Trp) and its metabolites, such as serotonin (5-HT) and kynurenines (KYNs), are strong modulators

Modulation of Tryptophan Metabolism, Promotion of ...Abstract: Although tryptophan (Trp) and its metabolites, such as serotonin (5-HT) and kynurenines (KYNs), are strong modulators

Chromatographic Studies of Purine Metabolism IV. Reversal ... · Chromatographic Studies of Purine Metabolism IV. Reversal of Azaserine-induced Inhibition by Phenylalanine and Tryptophan*

Chromatographic Studies of Purine Metabolism IV. Reversal ... · Chromatographic Studies of Purine Metabolism IV. Reversal of Azaserine-induced Inhibition by Phenylalanine and Tryptophan*

Metabolism Chapter 5. Metabolism This is a simple Diagram of the Metabolic pathways For Tryptophan Alone. Copyright 2009, John Ireland.

Metabolism Chapter 5. Metabolism This is a simple Diagram of the Metabolic pathways For Tryptophan Alone. Copyright 2009, John Ireland.

Neurochemical Imbalances and Autism: Tetrahydrobiopterin ... · •677 –related more to folate metabolism •1298–dopamine, serotonin, ammonia, tyrosine & tryptophan metabolism

Neurochemical Imbalances and Autism: Tetrahydrobiopterin ... · •677 –related more to folate metabolism •1298–dopamine, serotonin, ammonia, tyrosine & tryptophan metabolism

TRYPTOPHAN METABOLISM

TRYPTOPHAN METABOLISM

Tryptophan-kynurenine metabolism: a link between the gut ...

Tryptophan-kynurenine metabolism: a link between the gut ...

Indoleamine 2,3-dioxygenase (IDO) Immune Pathway · Indoleamine 2,3-dioxygenase (IDO) is an intracellular enzyme that initiates the breakdown of tryptophan in the tumor microenvironment.1,2

Indoleamine 2,3-dioxygenase (IDO) Immune Pathway · Indoleamine 2,3-dioxygenase (IDO) is an intracellular enzyme that initiates the breakdown of tryptophan in the tumor microenvironment.1,2

Tryptophan-2,3-Dioxygenase (TDO) deficiency is associated ...pathway regulating immune responses and neurotoxicity. The rate-limiting step is controlled by indoleamine-2,3-dioxygenase

Tryptophan-2,3-Dioxygenase (TDO) deficiency is associated ...pathway regulating immune responses and neurotoxicity. The rate-limiting step is controlled by indoleamine-2,3-dioxygenase

Tryptophan metabolism depression · Tryptophan metabolism in depression uponrat liver pyrrolase andbrain 5HTsuggests the possibility ofsuch a mechanism, which has recently beendiscussed

Tryptophan metabolism depression · Tryptophan metabolism in depression uponrat liver pyrrolase andbrain 5HTsuggests the possibility ofsuch a mechanism, which has recently beendiscussed

University of Groningen Tryptophan Metabolism via the ...

University of Groningen Tryptophan Metabolism via the ...

The role of arginine and tryptophan metabolism in sepsis13194/Thesis_CDU_13194_Darcy_C.pdf · The role of arginine and tryptophan metabolism in sepsis by Christabelle Jean Darcy BSc

The role of arginine and tryptophan metabolism in sepsis13194/Thesis_CDU_13194_Darcy_C.pdf · The role of arginine and tryptophan metabolism in sepsis by Christabelle Jean Darcy BSc

Microbiota tryptophan metabolism induces aryl hydrocarbon ...

Microbiota tryptophan metabolism induces aryl hydrocarbon ...

Kynurenine production is reduced by acute tryptophan ... · Scale; PSQI, Pittsburgh Sleep Quality Index. Figure 4. Summary of tryptophan metabolism in the central nervous system.

Kynurenine production is reduced by acute tryptophan ... · Scale; PSQI, Pittsburgh Sleep Quality Index. Figure 4. Summary of tryptophan metabolism in the central nervous system.

Metabolismof Tryptophan, Indole-3-acetic Acid, andRelated ... · TRYPTOPHAN METABOLISM IN OROBANCHE Table II. Indolic CompoundsFormedasMetabolitesby ThreeSpecies ofOrobanche Plant

Metabolismof Tryptophan, Indole-3-acetic Acid, andRelated ... · TRYPTOPHAN METABOLISM IN OROBANCHE Table II. Indolic CompoundsFormedasMetabolitesby ThreeSpecies ofOrobanche Plant

Role of the indoleamine-2,3-dioxygenase/kynurenine pathway ... · kynurenine pathway of tryptophan metabolism in behavioral alterations in a hepatic encephalopathy rat model Xi Jiang1,3*†,

Role of the indoleamine-2,3-dioxygenase/kynurenine pathway ... · kynurenine pathway of tryptophan metabolism in behavioral alterations in a hepatic encephalopathy rat model Xi Jiang1,3*†,

No Pathway Pathway Diagram Enzymes, Genes · 2013-10-07 · riboflavin kinase FMN1 FAD synthetase FAD1 . 40 tryptophan degradation via kynurenine Tryptophan 2,3 -dioxygenase BNA2

No Pathway Pathway Diagram Enzymes, Genes · 2013-10-07 · riboflavin kinase FMN1 FAD synthetase FAD1 . 40 tryptophan degradation via kynurenine Tryptophan 2,3 -dioxygenase BNA2

Archives of Biochemistry and Biophysicsferadical.utsa.edu/pdf/ABB2014-TDO.pdf · Tryptophan 2,3-dioxygenase (TDO)1 is the first functionally de-fined heme-dependent dioxygenase

Archives of Biochemistry and Biophysicsferadical.utsa.edu/pdf/ABB2014-TDO.pdf · Tryptophan 2,3-dioxygenase (TDO)1 is the first functionally de-fined heme-dependent dioxygenase

Increased Tryptophan Metabolism is Associated With ... · Krawczak M, Szymczak S, Schreiber S, Increased Tryptophan Metabolism is Associated With Activity of Inflammatory Bowel Diseases,

Increased Tryptophan Metabolism is Associated With ... · Krawczak M, Szymczak S, Schreiber S, Increased Tryptophan Metabolism is Associated With Activity of Inflammatory Bowel Diseases,

University of Groningen Tryptophan metabolism in aging and ... · tryptophan metabolism and controls internal free tryptophan levels (Van der Goot et al., 2012). Whereas IDO can bind

University of Groningen Tryptophan metabolism in aging and ... · tryptophan metabolism and controls internal free tryptophan levels (Van der Goot et al., 2012). Whereas IDO can bind

The$Relationship$Between$Maternal$ Tryptophan$Metabolism ...undergraduatelibrary.org/system/files/1251.pdf · via the Kyn pathway (Luigi et al. 2013). Two enzymes, tryptophan 2,3-dioxygenase

The$Relationship$Between$Maternal$ Tryptophan$Metabolism ...undergraduatelibrary.org/system/files/1251.pdf · via the Kyn pathway (Luigi et al. 2013). Two enzymes, tryptophan 2,3-dioxygenase