True or false? Blood is red because of the iron in hemoglobin.
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Transcript of True or false? Blood is red because of the iron in hemoglobin.
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True or false?
Blood is red because of the iron in hemoglobin.
“Red blood cells”A close-up of red bloodcells within a capillary.
Over 99 percentof the blood vessels in the
body are capillaries,even though they only hold 5 percent of the body’s blood.
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False
por·phy·rinFunction: nounEtymology: from Greek porphyra purple
-any of various compounds with a macrocyclic structure that consists essentially of four pyrrole rings joined by four =CH- groups; especially : one (as chlorophyll or hemoglobin) containing a central metal atom and usually exhibiting biological activity
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How to draw a porphyrin:
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Protoporphyrin IX
Glycine +Succinyl CoA
the pyrrole ring is formed
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HN
R
O
aldehyde
propionic acid
pyrrole
+
N
N
HNNHΔ
R
R
R
R
The Adler synthesis of simple, symmetrically substituted porphyrins:
Meso position
R = phenyl (TPP) toluyl (TTP) p-chlorophenyl (TClPP)
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The Ru-DNA Binding Project
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N
N
KBr,Conc. H2SO4Conc. HNO3
95 dec C, 2.5 h
N
N
O
O
1, 10-phenanthroline 1, 10-phenanthroline-5,6-dione
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N
N N
N
NH
NH
O
O
N
N O
O
N
N N
N
N
N
O
O
CH3
CH3
N
N N
N
NH
N
O
NH2
N
N N
N
N
N
NH2
NH2
H2N
H2N
NH
NH
O
O
H2N
H2N
N
N
O
O
CH3
CH3
H2N
H2N
NH
N
O
NH2
H2N
H2N
N
N
NH2
NH2
NaOH, pH ~11
MeOH, 20 h
"phen-alloxazine"
(L-allox)
"phen-dimethylalloxazine"
(L-Me2allox)
"phen-pterin" (L-pterin)
"phen-diaminopteridine"
(L-diamino)
N
N N
N
N
N
NH2H2N
H2N
N
N
NH2"phen-aminopteridine"
(L-amino)
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Ligand Synthesis: Condensations are a Theme
Schiff-Base Ligands
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N
N
O
N
NN
N
O
H
H
H
H
H
R
N
N
C-pterin hydrogen bonding
N
N N
N
O
N
NN
N
O
H
H
H
H
H
R
R
C-G hydrogen bonding
Watson-Crick Base Pairing
N
NN
N
O
N
N N
N
O
H
H
H
H
H
R
R
N
N N
O
H
H
H
R
N
NN
N
O
N
N N
N
O
H
H
H
H
H
R
R
N
Ru N
N
N
N
N
N
N
N
N
O
N
HH
H
Triplex DNA Base Pairing
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The Ru-DNA Binding Project