Troponina T alta sensibilidade.pdf
-
Upload
ritapinto37 -
Category
Documents
-
view
16 -
download
0
Transcript of Troponina T alta sensibilidade.pdf
![Page 1: Troponina T alta sensibilidade.pdf](https://reader034.fdocuments.net/reader034/viewer/2022051215/55cf919e550346f57b8ef459/html5/thumbnails/1.jpg)
1
Troponina T ad alta sensibilità
16 dicembre 2010/10 gennaio 201131 gennaio 2011 Cesena
1 febbraio 2011 Rimini 7 febbraio 2011 Forlì
![Page 2: Troponina T alta sensibilidade.pdf](https://reader034.fdocuments.net/reader034/viewer/2022051215/55cf919e550346f57b8ef459/html5/thumbnails/2.jpg)
2
• È necessario che il laboratorio ed i reparti clinici trovino un accordo su quali cut-off sia meglio adottare
• I dosaggi ad alta sensibilità delle troponinecardiache I e T mostrano una migliore sensibilità analitica e clinica rispetto ai vecchi metodi meno sensibili.
• Questo incremento di sensibilità permetteràdi evidenziare più precocemente una necrosi cardiaca rispetto al passato.
![Page 3: Troponina T alta sensibilidade.pdf](https://reader034.fdocuments.net/reader034/viewer/2022051215/55cf919e550346f57b8ef459/html5/thumbnails/3.jpg)
3
• Circa la metà dei pazienti con sospetta sindrome coronarica acuta e Tn hs aumentate potrebbero avere patologie cardiache acute non causate da SCA.
• Misure seriate (entro le 3-6 ore) delle Tn utili a distinguere tra SCA e altre patologie acute non-ischemiche.
![Page 4: Troponina T alta sensibilidade.pdf](https://reader034.fdocuments.net/reader034/viewer/2022051215/55cf919e550346f57b8ef459/html5/thumbnails/4.jpg)
4
I professionisti suggeriscono
cautela
![Page 5: Troponina T alta sensibilidade.pdf](https://reader034.fdocuments.net/reader034/viewer/2022051215/55cf919e550346f57b8ef459/html5/thumbnails/5.jpg)
5
![Page 6: Troponina T alta sensibilidade.pdf](https://reader034.fdocuments.net/reader034/viewer/2022051215/55cf919e550346f57b8ef459/html5/thumbnails/6.jpg)
6
![Page 7: Troponina T alta sensibilidade.pdf](https://reader034.fdocuments.net/reader034/viewer/2022051215/55cf919e550346f57b8ef459/html5/thumbnails/7.jpg)
7
Le Aziende di diagnostici sono partiteLe aziende
sanitarie sono partite
![Page 8: Troponina T alta sensibilidade.pdf](https://reader034.fdocuments.net/reader034/viewer/2022051215/55cf919e550346f57b8ef459/html5/thumbnails/8.jpg)
8
![Page 9: Troponina T alta sensibilidade.pdf](https://reader034.fdocuments.net/reader034/viewer/2022051215/55cf919e550346f57b8ef459/html5/thumbnails/9.jpg)
9
![Page 10: Troponina T alta sensibilidade.pdf](https://reader034.fdocuments.net/reader034/viewer/2022051215/55cf919e550346f57b8ef459/html5/thumbnails/10.jpg)
10
![Page 11: Troponina T alta sensibilidade.pdf](https://reader034.fdocuments.net/reader034/viewer/2022051215/55cf919e550346f57b8ef459/html5/thumbnails/11.jpg)
11
![Page 12: Troponina T alta sensibilidade.pdf](https://reader034.fdocuments.net/reader034/viewer/2022051215/55cf919e550346f57b8ef459/html5/thumbnails/12.jpg)
12
![Page 13: Troponina T alta sensibilidade.pdf](https://reader034.fdocuments.net/reader034/viewer/2022051215/55cf919e550346f57b8ef459/html5/thumbnails/13.jpg)
13
0.03 g/L Tropo T =
50 ng/l Tropo T hs
![Page 14: Troponina T alta sensibilidade.pdf](https://reader034.fdocuments.net/reader034/viewer/2022051215/55cf919e550346f57b8ef459/html5/thumbnails/14.jpg)
14
![Page 15: Troponina T alta sensibilidade.pdf](https://reader034.fdocuments.net/reader034/viewer/2022051215/55cf919e550346f57b8ef459/html5/thumbnails/15.jpg)
15
AVRAVR
![Page 16: Troponina T alta sensibilidade.pdf](https://reader034.fdocuments.net/reader034/viewer/2022051215/55cf919e550346f57b8ef459/html5/thumbnails/16.jpg)
16
![Page 17: Troponina T alta sensibilidade.pdf](https://reader034.fdocuments.net/reader034/viewer/2022051215/55cf919e550346f57b8ef459/html5/thumbnails/17.jpg)
17
![Page 18: Troponina T alta sensibilidade.pdf](https://reader034.fdocuments.net/reader034/viewer/2022051215/55cf919e550346f57b8ef459/html5/thumbnails/18.jpg)
18
![Page 19: Troponina T alta sensibilidade.pdf](https://reader034.fdocuments.net/reader034/viewer/2022051215/55cf919e550346f57b8ef459/html5/thumbnails/19.jpg)
19
rule outrule out
![Page 20: Troponina T alta sensibilidade.pdf](https://reader034.fdocuments.net/reader034/viewer/2022051215/55cf919e550346f57b8ef459/html5/thumbnails/20.jpg)
20
rule inrule in
![Page 21: Troponina T alta sensibilidade.pdf](https://reader034.fdocuments.net/reader034/viewer/2022051215/55cf919e550346f57b8ef459/html5/thumbnails/21.jpg)
21
MementoMemento
![Page 22: Troponina T alta sensibilidade.pdf](https://reader034.fdocuments.net/reader034/viewer/2022051215/55cf919e550346f57b8ef459/html5/thumbnails/22.jpg)
22
Rimangono le
troponinosi
Rimangono le
troponinosi
![Page 23: Troponina T alta sensibilidade.pdf](https://reader034.fdocuments.net/reader034/viewer/2022051215/55cf919e550346f57b8ef459/html5/thumbnails/23.jpg)
23
![Page 24: Troponina T alta sensibilidade.pdf](https://reader034.fdocuments.net/reader034/viewer/2022051215/55cf919e550346f57b8ef459/html5/thumbnails/24.jpg)
24
Mean age 44±13.8 yearsMean age 44±13.8 years
![Page 25: Troponina T alta sensibilidade.pdf](https://reader034.fdocuments.net/reader034/viewer/2022051215/55cf919e550346f57b8ef459/html5/thumbnails/25.jpg)
25
![Page 26: Troponina T alta sensibilidade.pdf](https://reader034.fdocuments.net/reader034/viewer/2022051215/55cf919e550346f57b8ef459/html5/thumbnails/26.jpg)
26
![Page 27: Troponina T alta sensibilidade.pdf](https://reader034.fdocuments.net/reader034/viewer/2022051215/55cf919e550346f57b8ef459/html5/thumbnails/27.jpg)
27
The Roche Elecsys high sensitive troponin T (hsTnT) assay meets theseperformance criteria (10% CV is at 13 ng/L, the 99°percentile is 14 ng/L) and isnow being introduced in laboratoriesthroughout the world.
in June in Manchester Clinical Biochemists and Roche
![Page 28: Troponina T alta sensibilidade.pdf](https://reader034.fdocuments.net/reader034/viewer/2022051215/55cf919e550346f57b8ef459/html5/thumbnails/28.jpg)
28
the reporting units should be ng/Lresults reported down to 3 ng/Ltwo measurements required2° sample: 6-9 hours after presentationif the 2°sample not an incrementalrise, yet clinical suspicion, a furthersample at 12 hours.
in June in Manchester Clinical Biochemists and Roche
![Page 29: Troponina T alta sensibilidade.pdf](https://reader034.fdocuments.net/reader034/viewer/2022051215/55cf919e550346f57b8ef459/html5/thumbnails/29.jpg)
29
a: Less than 20% change: notconsistent with an acute eventb: 20-100% change: suggestfurther evaluationc: Greater than 100% change: consistent with myocardialinfarction.
in summer in Cardiff Clinical Biochemists and Roche
![Page 30: Troponina T alta sensibilidade.pdf](https://reader034.fdocuments.net/reader034/viewer/2022051215/55cf919e550346f57b8ef459/html5/thumbnails/30.jpg)
30
Patients with hsTnT chronically >14 ng/Lare at risk of future cardiac eventsNo conclusion was reached on whatsingle level of hsTnT could be used todiagnose an MIIt is recognised that as evidenceaccumulates, practices may changeaccordingly. A consensus approach is preferableto multiple local practices.
in June in Manchester Clinical Biochemists and Roche
![Page 31: Troponina T alta sensibilidade.pdf](https://reader034.fdocuments.net/reader034/viewer/2022051215/55cf919e550346f57b8ef459/html5/thumbnails/31.jpg)
31
![Page 32: Troponina T alta sensibilidade.pdf](https://reader034.fdocuments.net/reader034/viewer/2022051215/55cf919e550346f57b8ef459/html5/thumbnails/32.jpg)
32
![Page 33: Troponina T alta sensibilidade.pdf](https://reader034.fdocuments.net/reader034/viewer/2022051215/55cf919e550346f57b8ef459/html5/thumbnails/33.jpg)
33
Results reported in ng/L
Results from the hs-TnT assay will bereported in ng/L rather than the previously used ug/L. This producesnumber which are 1000 times higherand all results will be in wholenumbers. For example a result of 0.015 ug/L becomes 15 ng/L. This willreduce reading and transcriptionerrors.
![Page 34: Troponina T alta sensibilidade.pdf](https://reader034.fdocuments.net/reader034/viewer/2022051215/55cf919e550346f57b8ef459/html5/thumbnails/34.jpg)
34
New Reference Interval:0-14 ng/LResults of 15 ng/L and above are considered elevated.It is estimated that here will bemore 2-3 times patients withelevated troponinMany of these will have conditionsother than ACS
![Page 35: Troponina T alta sensibilidade.pdf](https://reader034.fdocuments.net/reader034/viewer/2022051215/55cf919e550346f57b8ef459/html5/thumbnails/35.jpg)
35
AMIPatients with a good history for AMI and Troponin T >100 ng/L can be diagnosed with a single Tn resultA delta troponin >30% within3 – 12 hours together with at leastone Tn hs supportive of AMI.A stable troponin elevation (delta less than 30%) is more likely in other diagnoses.
![Page 36: Troponina T alta sensibilidade.pdf](https://reader034.fdocuments.net/reader034/viewer/2022051215/55cf919e550346f57b8ef459/html5/thumbnails/36.jpg)
36
![Page 37: Troponina T alta sensibilidade.pdf](https://reader034.fdocuments.net/reader034/viewer/2022051215/55cf919e550346f57b8ef459/html5/thumbnails/37.jpg)
37
![Page 38: Troponina T alta sensibilidade.pdf](https://reader034.fdocuments.net/reader034/viewer/2022051215/55cf919e550346f57b8ef459/html5/thumbnails/38.jpg)
38
![Page 39: Troponina T alta sensibilidade.pdf](https://reader034.fdocuments.net/reader034/viewer/2022051215/55cf919e550346f57b8ef459/html5/thumbnails/39.jpg)
39
• 1.Units: It was agreed that the reportingunits for hs-cTnT should be ng/L
• 2.Reporting Limits: The consensus wasthat results should be reported down tothe limit of the blank (LOB) that is 3 ng/L.
• 3. It was agreed that 14 ng/L, the 99th percentile of hs-cTnT in healthyindividuals should be employed as the upper reference limit (URL).
![Page 40: Troponina T alta sensibilidade.pdf](https://reader034.fdocuments.net/reader034/viewer/2022051215/55cf919e550346f57b8ef459/html5/thumbnails/40.jpg)
40
Reference population study included616 apparently healthy volunteers and blood donors aged between 20 and 71 years. Exclusion criteria applied to the
healthy volunteers were diabetes, renal impairment, coronary arterial
disease, and cardiac structuralabnormalities (Echocardiogram
assessed).
Professor Giannitsis
![Page 41: Troponina T alta sensibilidade.pdf](https://reader034.fdocuments.net/reader034/viewer/2022051215/55cf919e550346f57b8ef459/html5/thumbnails/41.jpg)
41
It was agreed that• 4. Clinical Significance this new hs-
cTnT assay will enable more rapiddiagnosis of MI but will also increasethe detection frequency of Tnelevations not due to ACS
• 5. Serial Measurements at least twomeasurements of hs-cTnT are essential to satisfy the UDMI. The first sample to be collected on presentationand the second, 6 hours later.
![Page 42: Troponina T alta sensibilidade.pdf](https://reader034.fdocuments.net/reader034/viewer/2022051215/55cf919e550346f57b8ef459/html5/thumbnails/42.jpg)
42
• In an evolving MI, hs-cTnT wouldbe expected to rise above >14 ng/L within the first 6 hrs after presentation with a delta changeof at least 100%
• A delta change of <20% within6 hrs was not consistent with anacute event.
It was agreed that
![Page 43: Troponina T alta sensibilidade.pdf](https://reader034.fdocuments.net/reader034/viewer/2022051215/55cf919e550346f57b8ef459/html5/thumbnails/43.jpg)
43
8. Report CommentsIt was suggested that
interpretative comments thataccompany hs-cTnT resultsshould be harmonised. Time
constraints did not allowconsensus to be reached
![Page 44: Troponina T alta sensibilidade.pdf](https://reader034.fdocuments.net/reader034/viewer/2022051215/55cf919e550346f57b8ef459/html5/thumbnails/44.jpg)
44
![Page 45: Troponina T alta sensibilidade.pdf](https://reader034.fdocuments.net/reader034/viewer/2022051215/55cf919e550346f57b8ef459/html5/thumbnails/45.jpg)
45
Laboratorians in Norwayhave recommended not using the 99th
percentile as the cutoff for MI, but rather a higher level of 0.03 µg/L. “This is to avoidover-diagnosis of MI, a particular concern
in elderly patients, many of whom will havenormal values higher than 14 ng/L
circulating,” explained Omland.
![Page 46: Troponina T alta sensibilidade.pdf](https://reader034.fdocuments.net/reader034/viewer/2022051215/55cf919e550346f57b8ef459/html5/thumbnails/46.jpg)
46
Of importance, a negative sensitive troponin test will havea high negative predictivevalue, and may thus serve asan exclusionary test early in the diagnostic process.
![Page 47: Troponina T alta sensibilidade.pdf](https://reader034.fdocuments.net/reader034/viewer/2022051215/55cf919e550346f57b8ef459/html5/thumbnails/47.jpg)
47
As multiple conditions are associated with Tn elevation, pretest likelihood of disease, clinical presentation and serial testing will become increasinglyimportant for identifying thosepatients with true acute coronarysyndromes
![Page 48: Troponina T alta sensibilidade.pdf](https://reader034.fdocuments.net/reader034/viewer/2022051215/55cf919e550346f57b8ef459/html5/thumbnails/48.jpg)
48
According to the hs-cTnT assay, all of the ESRD patients hadelevated cTnT concentrations at least once during the follow-up.
![Page 49: Troponina T alta sensibilidade.pdf](https://reader034.fdocuments.net/reader034/viewer/2022051215/55cf919e550346f57b8ef459/html5/thumbnails/49.jpg)
49
![Page 50: Troponina T alta sensibilidade.pdf](https://reader034.fdocuments.net/reader034/viewer/2022051215/55cf919e550346f57b8ef459/html5/thumbnails/50.jpg)
50
![Page 51: Troponina T alta sensibilidade.pdf](https://reader034.fdocuments.net/reader034/viewer/2022051215/55cf919e550346f57b8ef459/html5/thumbnails/51.jpg)
51
Ecco la ns
proposta di
referto
Ecco la ns
proposta di
referto
![Page 52: Troponina T alta sensibilidade.pdf](https://reader034.fdocuments.net/reader034/viewer/2022051215/55cf919e550346f57b8ef459/html5/thumbnails/52.jpg)
52
![Page 53: Troponina T alta sensibilidade.pdf](https://reader034.fdocuments.net/reader034/viewer/2022051215/55cf919e550346f57b8ef459/html5/thumbnails/53.jpg)
53
![Page 54: Troponina T alta sensibilidade.pdf](https://reader034.fdocuments.net/reader034/viewer/2022051215/55cf919e550346f57b8ef459/html5/thumbnails/54.jpg)
54
![Page 55: Troponina T alta sensibilidade.pdf](https://reader034.fdocuments.net/reader034/viewer/2022051215/55cf919e550346f57b8ef459/html5/thumbnails/55.jpg)
55
![Page 56: Troponina T alta sensibilidade.pdf](https://reader034.fdocuments.net/reader034/viewer/2022051215/55cf919e550346f57b8ef459/html5/thumbnails/56.jpg)
56
![Page 57: Troponina T alta sensibilidade.pdf](https://reader034.fdocuments.net/reader034/viewer/2022051215/55cf919e550346f57b8ef459/html5/thumbnails/57.jpg)
57
![Page 58: Troponina T alta sensibilidade.pdf](https://reader034.fdocuments.net/reader034/viewer/2022051215/55cf919e550346f57b8ef459/html5/thumbnails/58.jpg)
58
![Page 59: Troponina T alta sensibilidade.pdf](https://reader034.fdocuments.net/reader034/viewer/2022051215/55cf919e550346f57b8ef459/html5/thumbnails/59.jpg)
59
![Page 60: Troponina T alta sensibilidade.pdf](https://reader034.fdocuments.net/reader034/viewer/2022051215/55cf919e550346f57b8ef459/html5/thumbnails/60.jpg)
60