8/13/2019 Transforming Drug Development - Health 2.0 New Orleans

1/24

Transforming Drug DevelopmentIts not just for researchers you can participate!

Health 2.0 New Orleans

November 21, 2013

Thomas Krohn, RPh, MBA

Eli Lilly and Company

8/13/2019 Transforming Drug Development - Health 2.0 New Orleans

2/24

Drug Development - today

Precompetitive Competitivepatent

Innovation Process

8/13/2019 Transforming Drug Development - Health 2.0 New Orleans

3/24

Business Model Performance

Source: FDA.gov

Productivity Down, Costs Up Future revenues under pressure

Unsustainable Business Model

8/13/2019 Transforming Drug Development - Health 2.0 New Orleans

4/24

Moores vs. Erooms Law

8/13/2019 Transforming Drug Development - Health 2.0 New Orleans

5/24

The Far Side

by Gary Larson

8/13/2019 Transforming Drug Development - Health 2.0 New Orleans

6/24

Incremental Improvement

8/13/2019 Transforming Drug Development - Health 2.0 New Orleans

7/24

8/13/2019 Transforming Drug Development - Health 2.0 New Orleans

8/24

Disruptive Innovation

to S1'

to S2

S1

Time

Performance

Disruptive

Change

Simpler, Faster, Cheaper?

8/13/2019 Transforming Drug Development - Health 2.0 New Orleans

9/24

Disruption in motion

8/13/2019 Transforming Drug Development - Health 2.0 New Orleans

10/24

Generation and Access to Data

8/13/2019 Transforming Drug Development - Health 2.0 New Orleans

11/24

Patient Digital Monitoring

8/13/2019 Transforming Drug Development - Health 2.0 New Orleans

12/24

Patient Communities

Patients as microexperts not subjects

8/13/2019 Transforming Drug Development - Health 2.0 New Orleans

13/24

Patient-Driven Research

8/13/2019 Transforming Drug Development - Health 2.0 New Orleans

14/24

The Disruption

Power to the Patient

8/13/2019 Transforming Drug Development - Health 2.0 New Orleans

15/24

Clinical Research as part of Healthcare

Public Perception 94% of people recognize the importance of participating in clinical research

in order to assist in the advancement of medical science. Yet 75% of the

general public state they have little to no knowledge about the clinicalresearch enterprise and the participation process. (www.centerwatch.com)

Less than five percent of cancer patients participate in clinical trials. If tenpercent participated, studies could be completed in one year, instead of thethree-five years that studies currently require. (National Cancer Institute)

It's not uncommon for your cancer doctor or treatment team to discuss theoption of a clinical trial as the best treatment choice for your cancer type.(www.mayoclinic.com)

Standard of Care Clinical Trial

Info & Innovation

8/13/2019 Transforming Drug Development - Health 2.0 New Orleans

16/24

ClinicalTrials.Gov and Patients

98,000,000Pageviews/Month1

Sources:1) clinicaltrials.gov site2) D. Zarin 2007 Overview

47,000,000Patient driven pageviews/Month

2

What if.?

8/13/2019 Transforming Drug Development - Health 2.0 New Orleans

17/24

1

Patient-Centric

Design

PatientVoice

2

Patient-Centric Study Representation & Voice

Study Representation

Informed ConsentDocumentCt.Gov

Study Design

Open

Platform

Patients

Clear eligibilityRisk/BenefitMy doctors roleStudy treatmentTime to resultsLogistics

Design Challenge

ctdesign.challengepost.com

November 14

8/13/2019 Transforming Drug Development - Health 2.0 New Orleans

18/24

8/13/2019 Transforming Drug Development - Health 2.0 New Orleans

19/24

Clinical Open Innovation

Open

Platform

Patients

api.lillycoi.com

DailyUpdates

OpenWeb

RESTAPI

8/13/2019 Transforming Drug Development - Health 2.0 New Orleans

20/24

Enabling patient matching to studies

Open

Platform

Patients

api.lillycoi.com

DailyUpdates

OpenWeb

RESTAPI

Patient StudyTarget Profiles

Study Sponsors

Patient &

Communities

Personal ElectronicMedical Records

MatchProcess

Consentto

Match

8/13/2019 Transforming Drug Development - Health 2.0 New Orleans

21/24

Patient Engagement App Challenge

http://patientengagement.challengepost.com

8/13/2019 Transforming Drug Development - Health 2.0 New Orleans

22/24

Join the transformation

Learn the business model Understand patient needs Identify options for value creation

Explore open data and patient engagement

Participate in challenges

Most people are afraid of making mistakes.Leaders are afraid of missing opportunities.

8/13/2019 Transforming Drug Development - Health 2.0 New Orleans

23/24

References

Website: www.lillycoi.com API: api.lillycoi.com App Lab: labs.lillycoi.com

Whitepaper: link

Twitter: @Lilly_COI, @takmad

8/13/2019 Transforming Drug Development - Health 2.0 New Orleans

24/24

Thanks!