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2014 Beijing Conference

Transforming Canada-China Educational Cooperation:

Significant Legacies and Future Challenges

Tsinghua UniversityBeijing, ChinaMay 9-10, 2014

Cardiovascular textiles: spectacular achievements of the

Donghua University/Laval University collaboration

Lu WANGDonghua University, Shanghai, China

Robert GUIDOINLaval University, Québec, Canada

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History3

Late 2006, the Ministry of Education in Beijing approved the International collaborative project entitled :"Biomaterial Textile Materials Science and Technology, No. B07024", also known as "111 Project".

Since 2007, Donghua University at the Songjiang Campus, Shanghai has been hosting a yearly International Forum on Biomedical Textile Material co-chaired by Professor Lu Wang from Donghua University and Professor Martin King from NCSU, Raleigh, US.

Summary4

Summary5

Summary6

The 111 project Joint collaborative research projects between

foreign scholars, Chinese university professors, healthcare professionals and graduate students.

Visitation of foreign scholars with the purpose of giving lectures and providing direction and collaboration, the writing and submission of grant proposals, the undertaking of research activities and the publication of original research findings in refereed scholarly journals.

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Focus areas8

Based upon the evaluation of the biomedical textile materials technology, the ministry of Education recommended the integration of the following concepts:1.Chemical modification technology of fiber materials, that is grafting therapeutic medicine on fiber materials and generating persistent and centralized treatment effect on the diseased tissues.

Focus areas9

2. Manufacture and characterization of electro spinning nano-fibers, influence of size and surface effects of nano-fibers on the growing environment of tissue cells.

3. Develop biotextile devices and tissue engineering scaffolds by multiple advanced textile manufacturing technologies.

Focus areas10

4. Develop functional patches and special equipments and quality assurance system for vascular prostheses.

5. Establish laboratory testing and evaluation system for internal tubular prostheses.

Participants with 111 project11

The participants in the project include fifteen international “guest” professors and nine professors from Donghua University. The fifteen “guest” professors come from nine different countries outside China and cover a wide range of disciplines and research interests related to medical applications in textiles. The common thread that weaves their interests together is the subject of biomedical textile materials and the application of science and technology to the design and development of medical textile and biotextile products for improved healthcare.

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The Donghua University professors, who are participating in the project, have an equally diverse range of research and teaching interests, and are associated with the College of Textiles, Materials Science & Engineering and the Institute of Biological Sciences and Biotechnology (IBSB).

Participants with 111 project

Chairperson:Dr. Martin W. King North Carolina State University, USA

Members:

The first International Forum on Biomedical Textile Materials and Annual Meeting of the "111

Project " - May 30-June 2, 2007

Dr. James ANDERSON, MD Case Western Reserve University, Cleveland, USA

Dr. BAI Lun Soochow University, Soochow, PR China

Dr. CAO Yilin Shanghai JiaoTong, Shanghai, University, PR China

Dr. C.C. CHU Cornell University, Ithica, USA

Dr. George DU Gangwu InterVascular Inc., Clearwater, USA

Dr. GU Zhongwei Sichuan University, Chengdu, PR China

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Dr. Robert GUIDOIN Laval University, Québec, Canada

Dr. Lubos HES Technical University of Liberec, Liberec, Czech Republic

Dr. Dietmar W. HUTMACHER Queensland University of Technology, Brisbane, Australia

Dr. KIM Soo-Hyun Korean Institute of Science & Technology, Seoul, South Korea

Dr. Georgi MARINOV, MD Medical University of Varna, Varna, Bulgaria

Dr. Pertti NOUSIAINEN Tampere University of Technology, Tampere, Finland

Dr. PAN Ning University of California, Davis, USA

Members

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Dr. QING Fengling Donghua University, Shanghai, PR China

Dr. Seeran RAMAKRISHINA National University of Singapore, Singapore, Thailand

Dr. SUN Gang University of California, Davis, USA

Dr. Bojana VONCINA University of Maribor, Maribor, Slovenia

Dr. WANG, Lu Donghua University, Shanghai, PR China

Dr. XI Tingfei National Institute for the Control of Pharmaceutical & Biological Products, Beijing, PR China

Dr. XIAO Zhicheng, MD Singapore General Hospital, Singapore, Thailand

Members

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Organization of the 111 project18

1) Advancing research in biomedical textile materials: the discipline of textile service and engineering was promoted.2) Developing and maturing of talented scientists.3) Cultivating talented researchers and research teams.4) Stable cooperation relationship.5) Frequent and effective academic exchanges.

Collaboration Donghua University and Laval University

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1) Developing major research projects on the evaluation of devices (stent-graft, percutaneous valves) harvested at autopsy or reoperation, the validation of concepts for new commercially available devices, the development of innovative blood conduits to prevent fatigue and endoleaks.

2) Training of graduate students to link textile material and technology issue to biological requirements with the 3Bs concept of biocompatibility, biofunctionality and biodurability as its central paradigm.

3) Supporting independent programs to open new avenues regarding biofunctionalized materials, innovative textiles materials and customized technologies.

Summary20

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Support of teaching at Donghua University

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Undergraduate program: high technology textiles and functional materials, biomedical textile and technology.Graduate program leading to a master or PhD degree. The program was approved in 2009 and the first students were enrolled in 2010: 10-15 MSc, 6 PhD.Training, encouraging and supporting students to participate in Innovation competitions: 2 gold medals and 1 silver medal.

Young teachers involved in collaborative projects

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Name Degree Project Year

Fujun Wang PhDCuffs for

fenestrated stent-grafts

2007-to 2014

Jing Lin PhD

In vitro fatigue simulation for

stent- grafts and in situ fenestration of

stent grafts

2009-to now

Guoping Guan PhD

Silk/Polyester small diameter

vascular prostheses

2009-to now

Students involved in collaborative projects

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Name Degree Project Year

Xu, Lu MSc Degradation of polyester grafts 2006 - 2009

Jiang, Hua MSc Compliance testing 2007 - 2010

Ji, Xiaoping MSc PTFE structures and properties;weft knitting fabric for stent-grafts 2008 - 2011

Liu Bing MSc Stent-graft fatigue 2011 - 2013

Guan, Xiaoning MSc Biostability study of stent-grafts 2012 - 2014

Zou, Qiuhua MSc Valsalva 2013 - 2015

Miao, Linli MSc Meshes hernia 2013 - 2015

Zhao, Huijing PhD Fatigue of stent-grafts 2006 - 2009

Fu, Yijun PhD Valsalva and stent-grafts 2012 - 2015

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Achievements26

1) Conferences, communications, abstracts: (21 since 2007): UK, 2; Canada, 4; USA, 2; Finland, 1; Hong Kong, 1; China, 11.

2) Publications: (22 since 2007); published, 11; submitted, 6; in preparation, 5.

Understanding of cooperation27

Donghua University and Laval University signed an understanding of cooperation late 2012 thereby further cementing the long lasting and fruitful cooperation between our two institutions. A new era just began and we are confident in a bright future.

Laval University Team28

Robert Guidoin, PhD, Professor of Surgery (Biomaterials)Yvan Douville, MD, Head of the Department of SurgeryZe Zhang, PhD, Professor of Surgery (Biomaterials)Denis Desaulniers, MD, Professor of SurgeryGuy Dionne, MD, Professor of RadiologyGaétan Brochu, MD, Professor of Surgery

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Conclusion 130

This collaboration between Laval University and Donghua University has resulted in significant scientific advances in the field of biomedical textiles and more specifically the textiles employed to manufacture percutaneous devices for minimally invasive technology. The know-how that was acquired during the last 7 years should now be extended to other medical implants made of textiles. The development and analysis of new hernia patches are now part of the program.

Conclusion 231

The training of students is considered to be a top priority by both institutions. The students in medical textiles must be exposed more actively to the medical field for example by attending surgical operations as observers. This would provide them with a better understanding of the medical and surgical environment and an appreciation of the requirements of the medical community and patient concerns.

Conclusion 332

The minimally invasive technology has been mostly industry driven during the first two decades of its development and has rapidly reached a plateau. The academic research has demonstrated how it can influence and contribute to the development of new generations of devices to permit more patients to benefit of this technology. A better collaboration with industry and medical doctors will enable us to achieve new summits. In the meantime, a financial support from industry would be of considerable help for the academic research.

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