Prof: Gabriel GomilaStud: Mina Moeini

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inorganic semiconductor nanocrystals generally composed of atoms can be made to emit fluorescent light in the ultraviolet

to infrared spectrum just by varying their size the larger the QD, the longer the wavelength of the

emission

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Prostate cancer (The cancer cells spread to other parts of the body)

• Computer tomography (CT) ,poor soft-tissue contrast resolution

• Magnetic resonance image (MRI), better soft-tissue resolution

• Radionuclide imaging (RNI), improved specificity for cancer

• Positron emission tomography (PET),3D image labour intensive, time consuming, expensive and don’t

have multiplexing capability

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Multifunctional nanoparticle probes based onsemiconductor QDs for cancer cell imaging in livinganimals.

Encapsulating luminescent QDs with an ABC triblockcopolymer and linking amphiphilic polymer to tumortargeting ligands and drug delivery functionalities.

Core shell CdS/ZnS QDs are protected by acoordinating ligand, trinoctylphosphine oxide (TOPO),and an amphiphilic polymer coating.

High-quality , high levels of brightness, largeabsorption coefficients , more surface areas .

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BICONJUGATED QDS MEDICAL IMAGE PATENT

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human prostate cancer growing in nude mice indicate that the QD probes accumulate at tumors both by the enhanced permeability and retention of tumor sites and by antibody binding to cancer .

auto fluorescence background(a) clearly shows the whole animal and the tumor site (d).

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QDs are highly toxic to cells under UV illumination. surface ligands and coatings are slowly degraded in

body fluids. QDs with a stable polymer coating are essentially

nontoxic to cells. polymer protection layer is so stable that the QD core

would not be exposed to the outside environment. polymer-encapsulated QDs, chemical or enzymatic

degradation of the semiconductor cores is unlikely to occur.

polymer protected QDs might be cleared from the body by slows filtration and through the kidney

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