Traffic- Related Air Pollution: A Critical Review of the Literature on Emissions, Exposure, and...
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![Page 1: Traffic- Related Air Pollution: A Critical Review of the Literature on Emissions, Exposure, and Health Effects Society for Risk Analysis November 19, 2009.](https://reader035.fdocuments.net/reader035/viewer/2022062716/56649e105503460f94afbe15/html5/thumbnails/1.jpg)
Traffic- Related Air Pollution: A Critical Review of the Literature on
Emissions, Exposure, and Health Effects
Society for Risk AnalysisNovember 19, 2009
Maria CostantiniHealth Effects Institute
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Goals of the ReviewSummarize and synthesize relevant information on air pollution from traffic and its health effects linking• Information on tailpipe emissions with human
exposure to traffic –related pollution• Human exposure to traffic pollution with human
health effects (epidemiology)• Epidemiologic associations with toxicological
results
A preprint of the report released in May 2009Formal Report published in January 2010
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HEI Traffic Review PanelKenneth Demerjian—SUNY, Albany Mark Frampton—U Rochester Michael Jerrett—UC Berkeley Frank Kelly—King’s College Lester Kobzik—Harvard SPH Nino Künzli—IMdM, Barcelona Brian Leaderer—Yale SPH Thomas Lumley—U of Washington SPH Frederick Lurmann—Sonoma Tech. Inc Sylvia Richardson—Imperial CollegeJon Samet—Johns HopkinsIra Tager—UC Berkeley, ChairMichael Walsh—Consultant
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Emissions from Motor VehiclesThe Current Context
Significant progress has been made in reducing pollutant emissions from motor vehicles despite increases in number of vehicles and vehicle miles traveled
Increased urbanization and urban populations and changes in land use have:
– Increased dependence on motor vehicles and traffic congestion
more people are near traffic sources of pollution
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Emissions from Motor Vehicles
Emissions data and emission inventoriesare needed to: • Understand the relative contribution of motor vehicles
emissions to air pollution in total and at specific locations– Contribution to PM, CO, NOx,, VOCs
• Describe exposure– Trends in emissions in the context of transportation plans and
introduction of new control technologies and new fuels
• Improve the quality and range of pollutant surrogates
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Pollutant Surrogate Traffic Pollution
• CO
• NO2
• PM2.5
• EC (also referred to as BC, BS, or soot)
• Ultrafine PM
• Benzene
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Size Distribution of PM
3 main classes of PM
Coarse - PM2.5-10 mass
Fine - PM2.5 mass
Ultrafine – PM0.1 number
Courtesy of David Kittelson and Winn Watts, 2009
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Gradients of NO2 and PM from Source
From Beckerman et al 2008
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Spatial Extent Estimates
CO
EC
NO2
UFPM
Road to 100-400 m
Road to 200-500 m
Road to 100-300 m
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Assessment of Exposure to Primary Traffic-Generated Air Pollution
Surrogates of traffic exposure used inepidemiologic studies
– Pollutant surrogates (e.g., NO2, PM, EC/BS, CO, benzene, etc.)
– Traffic exposure models • Estimate of traffic density or intensity
• Distance from and/or length of roadways
• Complex models that provide surrogate concentrations
– Geostatistical interpolation, dispersion, land-use, and hybrid model
Direct measuresof traffic
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Conclusions on Traffic Exposure Surrogates
• None of the pollutant surrogates considered met all criteria for an ideal surrogate– CO, benzene, and NOx [NO2] found in on-road vehicle emissions are
components of emissions from all sources and are also contributed by indoor sources. They have substantial variability across locations. Can be useful if measured with final spatial resolution.
– PM2.5 as a surrogate of traffic pollution is of limited value because it is emitted by many sources and is well mixed within a region
– UFPM have not been used in epidemiologic studies so far because the characterization of their spatial concentration gradients pose a significant challenge
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Conclusions on Traffic Exposure Surrogates (cont.)
• Exposure models have various degrees of utility to health studies depending on the quality of the input data– The measure of distance to road is the most error-prone
and the least specific– Measures of traffic density and traffic flow are more
specific – The hybrid model provides a feasible “best” estimate of
exposure • Combines a model with time-activity data or personal
monitoring
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Epidemiology
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Epidemiology Criteria for Inclusion of Studies
Based on type of exposure metric• Only studies in which the pollutant surrogates of exposure used
were documented to have derived primarily from traffic or were measured in proximity of the residences and the roadways
• Studies based direct measures or models of traffic
Exposure based on traffic density or derived from exposure
models (other than proximity) considered to be “best” surrogates”
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Epidemiology Criteria for Causal Inference
4 categories1 used to infer causal association based on how well studies controlled for confounding, on the consistency of the findings across studies, and on the quality of the method to estimate exposure to primary traffic-generated pollutants
A.Sufficient evidence- all studies were of appropriate quality and at least one study measured traffic density or used modeled exposure
B.Suggestive but not sufficient evidence– as A, but studies only used distance measures
C. Inadequate and insufficient evidence
D. Suggestive of no association
1Adapted from US Surgeon General on the health consequences of ETS
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Epidemiology Health Outcomes Evaluated
• Mortality (all cause, cardiopulmonary)• Cardiovascular morbidity• Respiratory outcomes (children and adults)
– Asthma—childhood/adult– Respiratory symptoms– Health care utilization for respiratory problems– Lung function– COPD
• Non-asthmatic allergy (children)• Birth outcomes• Cancer (children and adults)
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Long-Term Traffic Exposure and Cardiopulmonary Mortality
Synthesis of Evidence
“Suggestive but insufficient” to infer causal association
Reasons
Too few studies
Relative imprecision of most estimates
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Traffic Exposure and Asthma Incidence (in Children)
Synthesis of Evidence“Sufficient” OR “suggestive but insufficient” to infer causal associationReasonsStudies including both traffic-specific pollutantsand density measures most consistentStudies on incidence were consistent with studies of prevalence
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Exacerbation of Asthma SymptomsIncrease in Wheeze in Children
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Exacerbation of Asthma SymptomsIncrease in Wheeze in Children (cont.)
Synthesis of EvidenceExacerbations with asthma—”Sufficient” to infer causal association
ReasonsLarge number of studies with adequate control for confounding and mostly precise effect estimates
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Other Respiratory Symptoms(in Children)
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Traffic Exposure and Allergies(in Children)
Synthesis of evidence“Inadequate and insufficient” to infer a causal association
ReasonWith a few inconsistent exceptions, results based on the skin-prick test or allergen-specific IgE failed to show associations with any of the traffic-pollutionResults for other endpoints (such as hay fever, eczema, itchy rash) were inconsistent
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Traffic Exposure and Allergies(in Children)
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Conclusions
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Exposure – Area of Impact
• Traffic-related pollutants impact ambient air quality on a broad spatial scale ranging from roadside, to urban, to regional background
• Based on synthesis of evidence, 300-500 meters from a major road was identified as the near-source area most impacted by traffic; variations exist depending on meteorology, background pollution, and local factors
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Conclusions From Epidemiologic Studies
• “Sufficient ” evidence to Infer causal associations– Exacerbation of asthma– Asthma incidence in children
• “Suggestive but insufficient” evidence– Mortality (all-cause and
cardiovascular)– Cardiovascular morbidity– Decreases in lung function– General respiratory symptoms
• “Inadequate and insufficient” evidence to Infer causal associations– Adult onset asthma
– Health care utilization for childhood and adult respiratory diseases
– COPD
– Non-asthmatic allergy
– Birth outcomes
– Cancers
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Comparison of Epi and Tox ConclusionsCardiovascular morbidity
Epi: Suggestive, but not sufficient Tox: Evidence from tox not sufficient in isolation, but consistent with some epi findings. A case could bemade for a potential causal role of traffic pollutants in cardiovascular-disease morbidity
Exacerbation of asthmaEpi: Sufficient Tox: Evidence supportive of epi conclusions, but
studies are limited in the endpoints evaluatedNon-asthmatic allergy
Epi: Inadequate and insufficient Tox: Data supported a stronger inference that the epi (by providing mechanistic evidence for associations of traffic pollution and IgE-mediated allergic reactions),but studies used non relevant exposure routes and doses
Birth outcomesEpi: Inadequate and insufficient No overlap in outcomes between epi and tox;
synthesis is not possibleCancers
Epi: Inadequate and insufficient Evidence from in vitro and long-term studies to DEfor DNA damage and carcinogenicity, but it is difficult to relate results to humans; synthesis is premature
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For a version of the report go to www.healtheffects.org