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    Ascending andDescending tracts ofthe central nervous

    systemDr Chathuranga Ranasinghe

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    Learning outcomes

    Describe stretch refex

    Describe upper motor neuron and lower motor neuron

    Describe the motor pathways(corticospinal, pyramidal

    tracts) and arrangement

    Outline the unctions o the extrapyramidal system

    riefy describe pathways or !ain, touch ,"ibration riefy describe the physiology o pain

    Outline the unctions o cerebellum , brain stem

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    #euron

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    #euromuscular $unction

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    %pinal cord

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    Refex arc

    &n"oluntary response to stimulus

    !arts o a refex arc

    #euromuscular spindle

    &n spinal cord refex arc plays a main role inmaintaining muscle tone ' basis o posture

    uscle tone continuous partial contraction o

    muscle ' depend on refex arc

    his refex arcs in the spinal cord is e*ected by thedescending tracts rom higher centers

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    uscle spindle

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    uscle spindle is sensiti"e to stretch+ change o length

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    olgi tendon Organ

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    Reciprocal inner"ation

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    Crossed extensor refex

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    -hat is .pper motor neuron/

    -hat is lower motor neuron/

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    .pper motor neuron and lower

    motor neuron

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    Upper motor neuron and lowermotor neuron

    Lesions

    Corticospinal excitatory0 increase muscletone

    Other tracts inhibit muscle tone

    1ypotonia Refex arc disrupted

    1ypertonia 2xtrapyramidal tracts disrupted

    ut clinically isolated lesions are rare

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    -hat are ascending anddescending tracts/

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    Descending tracts

    34 Corticospinal tract (Pyramidaltract) Lateral

    5nterior

    64 2xtrapyramydaltracts

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    Descending tracts

    First order neuron(upper motor)0 cerebral cortex0corona radiata0 post limb o internal capsule0

    &n the pons

    &n medulla0 anteriorly pyramids

    &nerior medulla deccussation o pyramids

    Lateral corticospinal tract

    7ibers do not cross anterior corticospinal tract 'later cross0cer"ical and upper thoracic

    5nterior gray column0 2ndorder neuron(interneuron) or directly

    3rdorder neuron(lower motor) ' alpha or gammamotor neuron

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    rain stem

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    orticospinal tract

    5lso called pyramidal tract

    !erorm rapid s8illed mo"ements

    ranches gi"en to other parts o cortex, nuclei

    Recei"e inormation rom other descending

    tracts(extrapyramidal tracts)

    Continues tonic excitatory infuence on lower

    motor neuron

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    !"trapyramidal tracts

    #eticulospinalinfuence "oluntery mo"ements and

    refex acti"ity

    $ectospinal ' refex posturalmo"ements in response

    to "isual stimuli

    %esti&ulospinal0 muscle acti"ity association with

    balance (inner ear, cerebellum)

    #u&rospinal

    &nhibitory infuence in muscle tone(L#)

    7unctions/

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    Ascending tracts

    34 Lateral spinothalamictract0 !ainand temparature0

    64 5nterior spinothalamic tract0 ouchand pressure

    94 !osterior white columnswo point discrimination

    !roprioception

    :ibration

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    Lateral spinothalamictract

    !ain and temperature

    7ast a delta

    %low c ;bers 5bo"e ;bers heat and cold

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    !athway06 m+s

    urning, aching

    %ubstance !

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    ating theory

    !eripheral ner"e ;ber and dorsalhorn cell( gate)

    Considerable plasticity

    %timulate large ;bers touch

    Collaterals rom those ;bers &nhibitpain ;bers at dorsal horn

    -hen that stimuli ta8en o* painoccur again

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    Anterior spinothalamic tract

    %ame as lateral spinothalamic tract

    a8e touch and pressure sensations

    ross to other side withinseveral spinal segments

    a8e spinal leminiscus with lateralspinothalamic tract

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    Discriminati"e touch, "ibration,proprioception(conscious)

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    Posterior white column

    %acral, lumber ,lower ? thoracic0 fasciculusgracilis

    .pper thorsic, cer"ical0 fasciculus cuneatus

    5scend ipsilaterally

    6ndorder gracilis cuneatus nucleas at medulla

    'ensory deccusation

    Ascend as medial leminiscus

    9rd

    order nueron at thalumus0 post limb o internalcapsule0 corona radiata0 sensory cortex

    Cuneocerebellar tract 'propriocepti"e sense tocerebellum

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    Read other ascending tracts

    %pinocerebellar tracts

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    Cerebellum

    7unctions

    Recei"e propriocepti"e,"isual, balanceinput rom body and a copy o motor

    plan rom the motor cortex %moothness and coordination o motor

    acti"ity by infuencing cortex and brain

    stem 2@uilibrium and learning

    Control o limb muscles

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    Cerebellum

    Clinical

    -ide drun8en gait, ataxia

    %canning o speech !ast pointing

    &ntention tremor

    Rebound phenomenon A canBt putbra8es

    5diadocho8inesia

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    rain stem

    7unctions %er"es as a conduit or ascending and

    descending tracts which connect spinal

    cord and higher centers4 Contains important centers which control

    Respiration

    Cardio"ascular system

    Consciousness

    1as cranial ner"e nuclei iii to xii

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    Learning outcomes

    Describe stretch refex

    Describe upper motor neuron and lower motor neuron

    Describe the motor pathways(corticospinal, pyramidal

    tracts) and arrangement

    Outline the unctions o the extrapyramidal system

    riefy describe pathways or !ain, touch ,"ibration

    riefy describe the physiology o pain

    Outline the unctions o cerebellum , brain stem

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    uestions/

    34 List 9important ascending tracts4nameunction o one tract

    64 -hat is the unction o the corticospinal

    tract94 5rrange the sectionso the central

    ner"ous system rom cortexdownwards(write the letters 5,,C

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    -rite the pathway

    !rimary motor cortex

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    %eparate paper ? F G H 3=

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    94 -as the lecture interesting or not/

    . (#ot interesting) (%ame as beore) (interesting

    than beore)3 6 9 E > ? F G H

    3=