Topic 8-2 Other Antibiotics · Protein synthesis inhibitors. Protein synthesis translation...

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Topic 8-2 Other Antibiotics Ch 16 Patrick P157- Infectious disease chapter- Corey

Transcript of Topic 8-2 Other Antibiotics · Protein synthesis inhibitors. Protein synthesis translation...

Page 1: Topic 8-2 Other Antibiotics · Protein synthesis inhibitors. Protein synthesis translation inhibitors. Protein synthesis translation inhibitors. Protein synthesis translation inhibitors

Topic 8-2 Other Antibiotics

Ch 16 PatrickP157- Infectious disease chapter-

Corey

Page 2: Topic 8-2 Other Antibiotics · Protein synthesis inhibitors. Protein synthesis translation inhibitors. Protein synthesis translation inhibitors. Protein synthesis translation inhibitors

Other cell wall inhibitors

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Vancomycin

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Protein synthesis inhibitors

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Protein synthesis translationinhibitors

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Protein synthesis translationinhibitors

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Protein synthesis translationinhibitors

Erythromycin

•Binds 50S ribosome•Low toxicity•Enteric coated to prevent aciddamage(ketal formation)

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Transcription and replicationinhibitors

Quinoline antibiotics

•Topo inhibitors•Gr + and Gr- esp Pseudomonas•Cipro is one of the best broadspectrum antibiotics•Used for resistant strains•Resistance forms due to effluxpumps mostly

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Rifamycins• RNA polymerase inhibitor,

Gr+ activity• Used for tuberculosis,

leprosy and resistantbacterial strains

• Can adversely effect otherdrugs (like HIV protease) byinducing CYP3A

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Drug resistance pumps

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Drug resistance pump assembled!


INHIBITORS OF PROTEIN SYNTHESIS - CORE · protein synthesis, but when added at low concentra- tions to growing bacterial cultures, it specifically blocks the initiation phase of protein

INHIBITORS OF PROTEIN SYNTHESIS - CORE · protein synthesis, but when added at low concentra- tions to growing bacterial cultures, it specifically blocks the initiation phase of protein

Pharmatube antibiotics-4-protein synthesis inhibitors (part 1)

Pharmatube antibiotics-4-protein synthesis inhibitors (part 1)

BATERIOCIDAL INHIBITORS OF PROTEIN SYNTHESIS I. AMINOGLYCOSIDES (all …courses.washington.edu/medch401/pdf_text/401_08_lecture... · 2008-04-02 · bateriocidal inhibitors of protein

BATERIOCIDAL INHIBITORS OF PROTEIN SYNTHESIS I. AMINOGLYCOSIDES (all …courses.washington.edu/medch401/pdf_text/401_08_lecture... · 2008-04-02 · bateriocidal inhibitors of protein

Synthesis of Six-Membered Rings and Inhibitors of Protein ... · Synthesis of Six-Membered Rings and Inhibitors of Protein Kinases Alexandros Kiriazis ACADEMIC DISSERTATION To be

Synthesis of Six-Membered Rings and Inhibitors of Protein ... · Synthesis of Six-Membered Rings and Inhibitors of Protein Kinases Alexandros Kiriazis ACADEMIC DISSERTATION To be

Chemotherapeutic Agents - Class Websitesclasses.biology.ucsd.edu/bimm118.WI17/PPT Lecture Notes/Lecture 16.pdf · Antibiotics - Protein synthesis inhibitors Protein synthesis inhibitors:

Chemotherapeutic Agents - Class Websitesclasses.biology.ucsd.edu/bimm118.WI17/PPT Lecture Notes/Lecture 16.pdf · Antibiotics - Protein synthesis inhibitors Protein synthesis inhibitors:

Inhibitors of Protein Synthesis · 2020. 4. 17. · Title: Microsoft PowerPoint - Inhibitors of Protein Synthesis Author: HIMADI Created Date: 4/16/2020 9:56:08 AM

Inhibitors of Protein Synthesis · 2020. 4. 17. · Title: Microsoft PowerPoint - Inhibitors of Protein Synthesis Author: HIMADI Created Date: 4/16/2020 9:56:08 AM

11-Protein Synthesis Inhibitors- Lincomycin & Others

11-Protein Synthesis Inhibitors- Lincomycin & Others

3. ANTIBIOTIC (PROTEIN SYNTHESIS INHIBITORS)

3. ANTIBIOTIC (PROTEIN SYNTHESIS INHIBITORS)

Inhibition by Prostaglandin Synthesis Inhibitors of the ... · affected neither normal epidermal protein nor DNA synthesis. The inhibition by the prostaglandin synthesis inhibitors

Inhibition by Prostaglandin Synthesis Inhibitors of the ... · affected neither normal epidermal protein nor DNA synthesis. The inhibition by the prostaglandin synthesis inhibitors

Effect of Mitochondrial Protein Synthesis Inhibitors on Erythroid

Effect of Mitochondrial Protein Synthesis Inhibitors on Erythroid

Protein Synthesis Inhibitors 2ND 11

Protein Synthesis Inhibitors 2ND 11

The apparent requirement for protein synthesis during G2 ... · 2 Protein synthesis inhibitors (e.g. cycloheximide) prevent cells from entering mitosis , 3 suggesting that cell cycle

The apparent requirement for protein synthesis during G2 ... · 2 Protein synthesis inhibitors (e.g. cycloheximide) prevent cells from entering mitosis , 3 suggesting that cell cycle

Protein synthesis inhibitors: Chloramphenicol, Tetracyclines, Macrolides, Clindamycin Streptogramins & Oxazolidinones Pawitra Pulbutr, M.Sc. In Pharm (Pharmacology)

Protein synthesis inhibitors: Chloramphenicol, Tetracyclines, Macrolides, Clindamycin Streptogramins & Oxazolidinones Pawitra Pulbutr, M.Sc. In Pharm (Pharmacology)

Pharmacology -Protein synthesis inhibitors 2

Pharmacology -Protein synthesis inhibitors 2

Protein Synthesis Inhibitors Dr. Rajendra Nath Dr. Rajendra Nath Professor.

Protein Synthesis Inhibitors Dr. Rajendra Nath Dr. Rajendra Nath Professor.

Effect of protein synthesis inhibitors on the function of the … · 2017. 3. 17. · This finding precludes the use of protein synthesis inhibitors for rapid modulation of KCC2 function.

Effect of protein synthesis inhibitors on the function of the … · 2017. 3. 17. · This finding precludes the use of protein synthesis inhibitors for rapid modulation of KCC2 function.

Antimicrobial TECHNICAL SERIES Testing · 3. Protein Synthesis Inhibitors : These types of antibiotics have numerous ways of attacking protein synthesis in bacterial cells and will

Antimicrobial TECHNICAL SERIES Testing · 3. Protein Synthesis Inhibitors : These types of antibiotics have numerous ways of attacking protein synthesis in bacterial cells and will

Prof. aza Bacterial Protein Synthesis Inhibitors (Antimicrobials) Reference: Gareth Thomas Week 14.

Prof. aza Bacterial Protein Synthesis Inhibitors (Antimicrobials) Reference: Gareth Thomas Week 14.

1 Inhibitors of Protein Synthesis Bacterial cells are 50% protein by dry weight –Inhibition of protein synthesis leads to cessation of growth or cell death.

1 Inhibitors of Protein Synthesis Bacterial cells are 50% protein by dry weight –Inhibition of protein synthesis leads to cessation of growth or cell death.

Chřipka - epidemiologie, diagnostika, léčba, profylaxe a ... · M-channel protein inhibitors Cyclic amines Amantadin, rimantadin, tromantadin Nucleic acid synthesis inhibitors

Chřipka - epidemiologie, diagnostika, léčba, profylaxe a ... · M-channel protein inhibitors Cyclic amines Amantadin, rimantadin, tromantadin Nucleic acid synthesis inhibitors