Tom Pozywio, PharmD Patients Prescribe... · 2019-04-05 · Infant concentration discontinued ......
Transcript of Tom Pozywio, PharmD Patients Prescribe... · 2019-04-05 · Infant concentration discontinued ......
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Tom Pozywio, PharmD
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Purdue University
Walgreens
Married with 2 Children
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Describe the difference between OTC medication and supplement
Drug class and common indications of popular OTC medications
Identify common prescription items that are often cheaper OTC
Identify potentially risky medications within situations
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OTC (Over the Counter) Supplements
Must obtain approval from the U.S. Food and Drug Administration ◦ FDA makes determination
whether a drug will be marketed as Rx-only or OTC
Prior to 1951, the manufacturer could decide if a drug was going to be marketed as Rx or OTC
“Provide proof of efficacy for their intended use”
Many forms ◦ Vitamin ◦ Mineral ◦ Herb or other botanical ◦ Amino Acid ◦ Dietary substance for use by
man to supplement the diet by increasing the total dietary intake; or
◦ A concentrate, metabolite, constituent, extract
“This product is not intended to diagnose, treat, cure, or prevent disease”
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Acetaminophen Ibuprofen Naproxen Aspirin
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Treats moderate pain and reduces fever Minimal side effects at normal dosage
(<4000 mg/day) Infant concentration discontinued
(80mg/0.8ml)
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NSAID: Pain reliever/Fever Reducer Only available 200mg OTC Side effects: upset stomach, nausea,
constipation, dizziness, drowsiness May raise blood pressure Caution if taking aspirin or other NSAIDs, anti
platelet/clotting agents Some patients are used to taking 3-4 OTC
ibuprofen at a time. When prescribed ibuprofen, they may think they need to take more than one at a time for pain relief
Beers List due to risk of GI bleed or peptic ulcer
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NSAID: Pain reliever, arthritis, bursitis, gout attacks
Side effects: Upset stomach, nausea, heartburn, drowsiness, dizziness
May raise blood pressure Caution of taking aspirin or other NSAIDS,
anti-platelet/clotting agents Beers List due to risk of GI bleed or peptic
ulcer
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Acetylsalicylic acid (ASA) Pain reliever, anti-clotting effects Can cause Reye’s Syndrome when given to
children under 18 AVOID using the phrase “Baby Aspirin” Pepto Bismol has aspirin derivative Beers List due to GI bleed and Peptic Ulcer
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Zyrtec (cetirizine) Claritin (loratadine) Allegra (fexofenadine) Xyzal (levocetirizine) Benadryl (diphenhydramine) Chlorpheniramine Doxylamine
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Relieves allergy symptoms ◦ Watery eyes ◦ Runny nose ◦ Itching ◦ Sneezing ◦ Hives
Side effects ◦ Drowsiness ◦ Dry mouth
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Treats: ◦ Itching ◦ Runny nose ◦ Watery eyes ◦ Sneezing ◦ Itching from hives
Non-drowsy Variety of dosage forms
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Relieves following symptoms: ◦ Watery eyes ◦ Runny nose ◦ Itching nose/eyes ◦ Sneezing ◦ Hives ◦ Itching
Antacids and fruit juices may decrease absorption
Side effects: ◦ Cough ◦ Fever ◦ Stomach upset
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Relieves allergy symptoms L-enantiomer of zyrtec Side effects: ◦ Drowsiness ◦ Tiredness ◦ Dry mouth
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Relieves allergy/cold symptoms Can treat allergic reactions and motion
sickness Side effects: drowsiness Beers List: confusion, dry mouth,
constipation, and other anticholinergic effects Also branded as “ZZZ Quil”
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Relieves allergy and cold symptoms Side effects: ◦ Drowsiness ◦ Dizziness ◦ Constipation ◦ Blurred vision ◦ Dryness
Beers List due to: ◦ Confusion, dry mouth, constipation, and other
anticholinergic effects
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Relieves allergy/cold symptoms Side effects: ◦ Drowsiness, dizziness, constipation, blurred vision,
dryness Beers List due to confusion, dry mouth,
constipation, etc. Avoid with glaucoma, hypertension, liver disease Branded as sleep-aid Unisom Diclegis/Bonjesta-combination of doxylamine
and vitamin B6 (pyridoxine) **Potential for major savings**
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Cetirizine Loratadine Fexofenadine Levocetirizine
Relieves Allergy
symptoms Allergy symptoms Allergy symptoms Allergy symptoms
Side effects Drowsiness Dry mouth
Cough Fever
Upset Stomach
Drowsiness Tiredness Dry Mouth
What to Avoid
Antacids and fruit juices
Background Non-drowsy
Variety of dosage forms
L-enantiomer of Zyrtec
Branded as Zyrtec Claritin Allegra Xyzal
Image
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Diphenhydramine Chlorpheniramine Doxylamine
Relieves Allergy/cold symptoms
Allergic reactions Motion sickness
Allergy/cold symptoms Allergy/cold symptoms
Side effects Drowsiness
Drowsiness Dizziness
Constipation Blurred Vision
Dryness
Drowsiness Dizziness
Constipation Blurred Vision
Dryness
Cautions Glaucoma
Hypertension Liver Disease
Beers List
Confusion Dry mouth
Constipation Other anticholinergic effects
Confusion Dry mouth
Constipation Other anticholinergic effects
Confusion Dry mouth
Constipation Other anticholinergic effects
Background
Diclegis/Bonjesta – combination of doxylamine and vitamin B6
(pyridoxine) Potential for major savings
Branded as Benadryl ZZZ Quil Unisom (sleep aid)
Image
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Nasacort (triamcinolone) Flonase (fluticasone) Afrin (oxymetazoline)
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Nasacort Flonase Afrin Drug Name Triamcinolone Fluticasone Oxymetalozine
Relieves Stuffy/runny nose
Itchy eyes, nose, or throat
Sneezing
Stuffy/runny nose Itching
Sneezing Nasal congestion
Side Effects
Nasal/throat dryness Cough
Sneezing Nose bleed
Unpleasant taste
Nasal dryness/irritation
Sneezing Nosebleed
Nausea/vomiting
Nasal burning, stinging, dryness
Sneezing Runny nose
Additional Info
Flonase-Sensimist RX/OTC
Rebound congestion
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Mucinex (Guaifenesin) Dextromethorphan Pseudoephedrine Phenylephrine
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Clears congestion by thinning and loosening mucus
Well-tolerated Multiple OTC combination products
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Cough Suppressant Side Effects: ◦ Mild drowsiness/dizziness ◦ Nausea/Vomiting ◦ Rare severe drowsiness/dizziness with normal
doses Sometimes abused Father John’s
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Relieves stuffy nose and sinus pressure/pain Side Effects: ◦ Nausea/vomiting ◦ Trouble sleeping ◦ Dizziness ◦ Headache ◦ Major caution – fast/irregular/pounding heartbeat,
increased blood pressure, glaucoma Beers List due to insomnia “Behind the Counter” (methamphetamine) Can write prescription to get around limit
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Industry answer to combat meth problems Relieves stuffy nose and sinus congestion Side Effects: ◦ Upset Stomach ◦ Trouble sleeping ◦ Dizziness/lightheadedness ◦ Headache ◦ Nervousness/Shaking ◦ Increased heartbeat ◦ May reduce blood flow to hands/feet, worsened by
smoking Beers List due to insomnia
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Proton Pump Inhibitors H2 Antagonists Antacids
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Prilosec Nexium Prevacid Drug Name Omeprazole Esomeprazole Lansoprazole
Treats Acid reflux/ulcers Acid reflux/ulcers Acid reflux/ulcers
When to Take Before a meal One hour before meal Before a meal
Side Effects Headaches
Generally well-tolerated
Diarrhea Headaches
Generally well-tolerated
Diarrhea Headaches
Generally well-tolerated
Drug Interactions
cilostazol clopidogrel
methotrexate rifampin
St John’s wort
Cilostazol clopidogrel, methotrexate
rifampin St John’s wort
Cilostazol clopidogrel, methotrexate
rifampin St John’s wort
May Affect Absorption Of
Atazanavir, erlotinib, nelfinavir, pazopanib, rilpivirine,
azole antifungals
Atazanavir, erlotinib, nelfinavir, pazopanib, rilpivirine, and azole
antifungals
Atazanavir, erlotinib, nelfinavir, pazopanib, rilpivirine, and azole
antifungals
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Zegerid ◦ Omeprazole and sodium bicarbonate ◦ Recently OTC ◦ Major cost savings vs prescription
Beers List – risk of C.Diff infection and bone
loss/fractures
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Famotidine Ranitidine Cimetidine ◦ Strong CYP3A4 inhibitor, inhibitor of many others
as well All for heartburn/indigestion
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Ibuprofen 800 mg and famotidine 26.6 mg HUGELY expensive Specialty drug
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Tums ◦ Calcium carbonate ◦ Directly neutralizes acid, fastest relief ◦ Side Effects: constipation, nausea ◦ Can decrease absorption of other drugs
including: tetracyclines, bisphosphates, estramustine, iron, levothyroxine, quinolone antibiotics
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Imodium Pepto Bismol Simethicone Mylanta
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Imodium Pepto Bismol Simethicone Mylanta
Contains Loperamide Bismuth Subsalicylate
Aluminum hydroxide/magnesium hydroxide/simethicone
Treats Diarrhea Upset
stomach Heartburn
Nausea Relieves gas Heartburn
Indigestion
Side Effects/Risks Constipation
May increase risk of
bleeding Well-tolerated
Other Info Abused by opioid addicts
Similar to aspirin
Anti-foaming agent – allows tiny bubbles to
collect into bigger, passable
ones
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Colace (docusate) Magnesium hydroxide Miralax Metamucil Magnesium citrate Bisacodyl
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Colace (docusate sodium) ◦ Increases amount of water the stool absorbs ◦ Becomes softer and easier to pass
Milk of Magnesia (Magnesium hydroxide) ◦ Osmotic-type laxative ◦ Also an antacid
Miralax (polyethylene glycol 3350) ◦ Osmotic-type laxative ◦ Powder
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Metamucil (psyllium) ◦ Dietary fiber ◦ Bulk forming ◦ Can treat constipation or mild diarrhea
Magnesium Citrate ◦ Saline laxative ◦ Increases fluid in small intestine ◦ Bowel movement in 30 minutes to 3 hours
Bisacodyl ◦ Stimulant laxative ◦ Dulcolax ◦ Tablets or suppository
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Phenazopyridine
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Treats: ◦ Pain ◦ Burning ◦ Urgency associated with UTI
Can change color of urine
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Meclizine
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Antihistamine: nausea, vomiting, dizziness with motion sickness
Reduces dizziness and loss of balance caused by inner ear problems
Beers List due to risk of confusion, dry mouth, constipation