Today- Oct. 31st
Transcript of Today- Oct. 31st
![Page 1: Today- Oct. 31st](https://reader030.fdocuments.net/reader030/viewer/2022020704/61fb69ad41e3d152f301187f/html5/thumbnails/1.jpg)
Neural Prosthetic Engineering
Today- Oct. 31st
• Questions? Projects?
• Review
– Speech Processing
• Recent updates
– By major commercial CI manufacturers
– New Technologies
1
![Page 2: Today- Oct. 31st](https://reader030.fdocuments.net/reader030/viewer/2022020704/61fb69ad41e3d152f301187f/html5/thumbnails/2.jpg)
Neural Prosthetic Engineering2
Review
![Page 3: Today- Oct. 31st](https://reader030.fdocuments.net/reader030/viewer/2022020704/61fb69ad41e3d152f301187f/html5/thumbnails/3.jpg)
Neural Prosthetic Engineering
Human Speech Generation
3
• Vocal fold generates sound that consists of fundamental
and harmonic frequencies (source of sound)
• Vocal tract modifies amplitudes of these frequency
components to make the sound distinguishable from
others (articulation by vocal tract).
![Page 4: Today- Oct. 31st](https://reader030.fdocuments.net/reader030/viewer/2022020704/61fb69ad41e3d152f301187f/html5/thumbnails/4.jpg)
Neural Prosthetic Engineering
Consonants/vowels/formants
4
Consonant and vowels
• Articulations at various places in vocal tract
• Roughly speaking,
• Vowels are lower frequency sounds
• Consonants are higher frequency sounds
• Formants are distinct frequency bands in the sound
spectrogram
• F1 and F2 may be used to represent vowels
• Consonants may need additional higher frequency
formants to be distinguished
• F0 is the fundamental frequency of the pitch
![Page 5: Today- Oct. 31st](https://reader030.fdocuments.net/reader030/viewer/2022020704/61fb69ad41e3d152f301187f/html5/thumbnails/5.jpg)
Neural Prosthetic Engineering
How we hear
5
• Temporal (Rate) code theory
• Place code theory
• Volley theory
• We use both Temporal(Rate) and Place Cues in hearing.
![Page 6: Today- Oct. 31st](https://reader030.fdocuments.net/reader030/viewer/2022020704/61fb69ad41e3d152f301187f/html5/thumbnails/6.jpg)
Neural Prosthetic Engineering
Hearing by Cochlear Implant
6
• Extracted features are used
• F0/F1/F2
• Analog waveforms are used
• Compressed Analog
• CIS uses extracted features and biphasic pulse
stimulation at a constant rate
![Page 7: Today- Oct. 31st](https://reader030.fdocuments.net/reader030/viewer/2022020704/61fb69ad41e3d152f301187f/html5/thumbnails/7.jpg)
Neural Prosthetic Engineering
What to improve
7
1.
2.
![Page 8: Today- Oct. 31st](https://reader030.fdocuments.net/reader030/viewer/2022020704/61fb69ad41e3d152f301187f/html5/thumbnails/8.jpg)
Neural Prosthetic Engineering
Development of Present and future Cochlear Implant Products and Performance
8
![Page 9: Today- Oct. 31st](https://reader030.fdocuments.net/reader030/viewer/2022020704/61fb69ad41e3d152f301187f/html5/thumbnails/9.jpg)
Neural Prosthetic Engineering
CI Milestones
• 1960 Single channel CI on three patients by William House
• 1976 A Multichannel CI on two patients by Graeme Clark
• 1977 Bilger report confirmed effectiveness of multichannel CI
• 1985 Nucleus 22 became the first Multichannel CI approved by FDA
• 1991 CIS speech processing strategy (Blake Wilson)
• 1997 Clarion (Advanced Bionics) device approved by FDA
• 2001 Medel device approved by FDA
• 2000’s EAS and Bilateral CI
Other milestone
• 1997 DBS (Activa manufactured by Medtronic) approved by FDA as a treatment for essential tremor and Parkinson's disease. Dystonia in 2003, and OCD in 2009.
• 2013 Argus II retinal implant (manufactured by Second Sight Medical Products) approved by FDA
9
F.G.Zeng et al., (IEEE Review in Biomedical Engineering, 2008)
![Page 10: Today- Oct. 31st](https://reader030.fdocuments.net/reader030/viewer/2022020704/61fb69ad41e3d152f301187f/html5/thumbnails/10.jpg)
Neural Prosthetic Engineering
History of the Cochlear Implant
• Pioneers
– Andre Djourno and Charles Eyries (in Paris, 1957)
• Eyries implants Djourno's induction coils in two patients
• Alternating current transmitted to the coil produces perception of sound
• Early Developments in the Western Hemisphere
– William House, John Doyle, James Doyle (Los Angeles, 1960)
• Effect electrical stimulation during stapes surgery
• Implant 3 patients with a single gold electrode
– Blair Simmons (Stanford University, 1964)
• Develops a six-electrode system using a percutaneous plug ( Ineraid)
– Robert Michelson (San Francisco, 1970)
• Implant 3 patients using a gold two-electrode system ( Advanced Bionics)
– William House (Los Angeles, 1972)
• First wearable cochlear implant device using a centering coil and magnet
• House/3M single channel cochlear implant (approved by the FDA in 1984)
Djourno
(Physiologist)
Eyries (ENT surgeon)
William House
(ENT Surgeon)
House/3M
single channel device
10
![Page 11: Today- Oct. 31st](https://reader030.fdocuments.net/reader030/viewer/2022020704/61fb69ad41e3d152f301187f/html5/thumbnails/11.jpg)
Neural Prosthetic Engineering
History of the Cochlear Implant
• Development of a Mutichannel Device (1970-80s)
– Single channel device Very Poor speech understanding
– Competition
• Michelson, Merzenich, Robert Schindler (UCSF) Advanced Bionics Corp.
• Hochmair (Vienna, Austria) Med-El GmbH.
• Graeme Clark (The University of Melbourne in Australia)
– Research supported by public donation (commenced 1967)
– First Multichannel Cochlear Implant Patient (1978) Cochlear Ltd.
• FDA Approved Multichannel CI Manufacturers
– Cochlear (Australia) – 1985
– Advanced Bionics (Austria) – 1996
– Med-El (Austria) – 2001 (1994 – European release)
• Lasker~DeBakey Clinical Medical Research Award (2013)
– Graeme M. Clark, Ingeborg Hochmair and Blake S. Wilson
• For the development of the modern cochlear implant - a device that bestows hearing to individuals with profound deafness.
Rod Saunders (First multi-
channel CI patient) and
Graeme Clark
11
![Page 12: Today- Oct. 31st](https://reader030.fdocuments.net/reader030/viewer/2022020704/61fb69ad41e3d152f301187f/html5/thumbnails/12.jpg)
Neural Prosthetic Engineering
Product History
12
1978 (by Michelson)
A.A.Eshraghi (The Anatomical Record, 2012)
1973 (by House,
single channel)
![Page 13: Today- Oct. 31st](https://reader030.fdocuments.net/reader030/viewer/2022020704/61fb69ad41e3d152f301187f/html5/thumbnails/13.jpg)
Neural Prosthetic Engineering
Product History
13
1985 (Cochlear Ltd. Nucleus,
FDA approval, multi-channel)
www.cochlear.com
1989 (Cochlear Ltd.
Mini speech processor)
![Page 14: Today- Oct. 31st](https://reader030.fdocuments.net/reader030/viewer/2022020704/61fb69ad41e3d152f301187f/html5/thumbnails/14.jpg)
Neural Prosthetic Engineering
Product History
14
1997 (Cochlear Ltd. Sprint,
Digital signal processor (DSP))
www.cochlear.com
2002 (Cochlear Ltd. Nucleus®
24 Contour Advance™, design
for structure preservation)
![Page 15: Today- Oct. 31st](https://reader030.fdocuments.net/reader030/viewer/2022020704/61fb69ad41e3d152f301187f/html5/thumbnails/15.jpg)
Neural Prosthetic Engineering
Product History
15www.cochlear.com
2008 (Cochlear Ltd. Hybrid,
hearing aid + cochlear implant) 2009 (Cochlear Ltd. Nucleus 5)
2015 (Cochlear Ltd. Nucleus 6,
smart speech processor)
![Page 16: Today- Oct. 31st](https://reader030.fdocuments.net/reader030/viewer/2022020704/61fb69ad41e3d152f301187f/html5/thumbnails/16.jpg)
Neural Prosthetic Engineering
Two Recent Advances
16
• Bilateral electrical stimulation
• Combined electric and acoustic
stimulation (EAS) for patients with
residual, low-frequency hearing
http://www.otosurgery.org/
![Page 17: Today- Oct. 31st](https://reader030.fdocuments.net/reader030/viewer/2022020704/61fb69ad41e3d152f301187f/html5/thumbnails/17.jpg)
Neural Prosthetic Engineering 17http://www.otosurgery.org/
Results with
bilateral
implants using
independent
processors,
Müller et al.,
2002
Sentences,Noise Right
right both left
Perc
ent
Corr
ect
0
20
40
60
80
100
Sentences,Noise Left
right both left
Monosyllabic Words,No Noise
right both left
32
86
96
107
118
148
151
257
298
Subjects
right both left
Perc
ent
Corr
ect
0
20
40
60
80
100
Implant(s)
right both left right both left
![Page 18: Today- Oct. 31st](https://reader030.fdocuments.net/reader030/viewer/2022020704/61fb69ad41e3d152f301187f/html5/thumbnails/18.jpg)
Neural Prosthetic Engineering 18http://www.otosurgery.org/
Combined Electric Acoustic Stimulation(EAS)
■ Combined EAS: Hearing Aid (HA) + Cochlear Implant (CI) on same ear
■ Many implant candidates Good low-frequency hearing but poor high frequency hearing
■ Low-frequency Acoustic Hearing using a HA
High-frequency Electrical Hearing using a CI
■ Good speech perception in noisy environments
■ Latest EAS technique
- Surgery: the round window approach (conventional method: cochleostomy)
- Electrode: flex, Short & thin electrode (half insertion)
Hybrid CI Device (HA+CI)
Ski-slope type SNHL
Sentence discrimination tests for a EAS patient
In quiet SNR 15 dB SNR 10 dB
W. Gstoettner et al. (Acta Oto-Laryngologica, 2004)
Hearing Aid (HA)
![Page 19: Today- Oct. 31st](https://reader030.fdocuments.net/reader030/viewer/2022020704/61fb69ad41e3d152f301187f/html5/thumbnails/19.jpg)
Neural Prosthetic Engineering
Performance of Cochlear Implant
19
B. S. Wilson and M. F. Dorman (IEEE Trans Biomed Eng, 2007)
Test
Star patient’s score
B. S. Wilson & M. Dorman (Hearing Research, 2008)
Percent correct scores for 55 CI users
![Page 20: Today- Oct. 31st](https://reader030.fdocuments.net/reader030/viewer/2022020704/61fb69ad41e3d152f301187f/html5/thumbnails/20.jpg)
Neural Prosthetic Engineering 20
Cochlear Implant Manufacturers
■ Big 3 companies
- Cochlear, Australia
- Med-El, Austria
- Advanced Bionics, USA
■ Others
- Oticon(Former Neurelec), France
- Nurotron, China
- Todoc, S. Korea
![Page 21: Today- Oct. 31st](https://reader030.fdocuments.net/reader030/viewer/2022020704/61fb69ad41e3d152f301187f/html5/thumbnails/21.jpg)
Neural Prosthetic Engineering 21
Cochlear Ltd.
■ Nucleus series
- Market leader
■ Dual microphones
- Directionality
■ Wireless control
- Interaction with TV and smartphone
■ Colorful designs
- Users satisfaction
■ Water-resistance
- Living convenience
■ Electric acoustic stimulation (EAS)
- High-performance
■ Data logging
- Rehabilitation
www.cochlear.com
![Page 22: Today- Oct. 31st](https://reader030.fdocuments.net/reader030/viewer/2022020704/61fb69ad41e3d152f301187f/html5/thumbnails/22.jpg)
Neural Prosthetic Engineering 22
Cochlear Ltd.
■ Thinnest cochlear implant among 3 major manufacturers
■ Advanced off stylet electrode array
- Perimodiolar electrode array
- Near zero insertion force
www.cochlear.com
![Page 23: Today- Oct. 31st](https://reader030.fdocuments.net/reader030/viewer/2022020704/61fb69ad41e3d152f301187f/html5/thumbnails/23.jpg)
Neural Prosthetic Engineering 23
Cochlear Ltd.
■ Smart speech processor (SmartSoundiQ)
- Integrated hybrid mode
- Wireless connectivity
- Data logging and analysis: information for next fitting
- Speech in noise, wind, quiet, and music modes
- Dual microphones
- Wind noise reduction (WNR)
www.cochlear.com
![Page 24: Today- Oct. 31st](https://reader030.fdocuments.net/reader030/viewer/2022020704/61fb69ad41e3d152f301187f/html5/thumbnails/24.jpg)
Neural Prosthetic Engineering 24
Med-El
■ Synchrony series
- Freely rotating and self-
aligning magnet
■ EAS
■ Water-resistance
■ Color options
■ Test in rainy environment
■ Wind noise reduction
■ 3.0 T MRI (with magnet)
- Other groups 1.5 T MRI
www.medel.com
![Page 25: Today- Oct. 31st](https://reader030.fdocuments.net/reader030/viewer/2022020704/61fb69ad41e3d152f301187f/html5/thumbnails/25.jpg)
Neural Prosthetic Engineering 25
Med-El
www.medel.com
![Page 26: Today- Oct. 31st](https://reader030.fdocuments.net/reader030/viewer/2022020704/61fb69ad41e3d152f301187f/html5/thumbnails/26.jpg)
Neural Prosthetic Engineering 26
Med-El
www.medel.com
■ Various types of electrode array
- Long electrode: for stimulation full
cochlea
- Short electrode: for EAS
■ Structure preservation
- Atraumatic insertion
- Reimplantation
![Page 27: Today- Oct. 31st](https://reader030.fdocuments.net/reader030/viewer/2022020704/61fb69ad41e3d152f301187f/html5/thumbnails/27.jpg)
Neural Prosthetic Engineering 27
Advanced Bionics
www.advancedbionics.com
■ Water-resistance
■ Wireless control
■ Colorful design
■ Dual microphones
■ Acquired by Sonova in
2009/ Co-working with
Phonak (hearing aid company)
■ EAS – FDA approval in Aug.
2015
![Page 28: Today- Oct. 31st](https://reader030.fdocuments.net/reader030/viewer/2022020704/61fb69ad41e3d152f301187f/html5/thumbnails/28.jpg)
Neural Prosthetic Engineering 28
Advanced Bionics
www.advancedbionics.com
■ HiFocus mid-scala electrode array
- Pre-curved electrode
![Page 29: Today- Oct. 31st](https://reader030.fdocuments.net/reader030/viewer/2022020704/61fb69ad41e3d152f301187f/html5/thumbnails/29.jpg)
Neural Prosthetic Engineering
New Technologies
29
![Page 30: Today- Oct. 31st](https://reader030.fdocuments.net/reader030/viewer/2022020704/61fb69ad41e3d152f301187f/html5/thumbnails/30.jpg)
Neural Prosthetic Engineering
Next Version of Cochlear Implant?
30
www.cochlear.com
www.cochlear.com
Candidates
1. Silicon-based
CI
2. Polymer-
based CI
3. Optical
stimulation
…
![Page 31: Today- Oct. 31st](https://reader030.fdocuments.net/reader030/viewer/2022020704/61fb69ad41e3d152f301187f/html5/thumbnails/31.jpg)
Neural Prosthetic Engineering
Silicon-Based Device
31
• Advantages of silicon-based neural implant
– Batch process
• High-yield
• Mass production
– MEMS technology
• Miniaturization
• High-density
• Highly functional device
• Integration
• Disadvantages of silicon-based neural implants
– Brittleness
– Stiffness
– Long-term reliability
![Page 32: Today- Oct. 31st](https://reader030.fdocuments.net/reader030/viewer/2022020704/61fb69ad41e3d152f301187f/html5/thumbnails/32.jpg)
Neural Prosthetic Engineering
Silicon-Based Device
32J.Wang and K.D.Wise, J.MEMS 2009.
J.Wang and K.D.Wise, J.MEMS 2008.
![Page 33: Today- Oct. 31st](https://reader030.fdocuments.net/reader030/viewer/2022020704/61fb69ad41e3d152f301187f/html5/thumbnails/33.jpg)
Neural Prosthetic Engineering
Polymer-Based Neural Implant
33
• Conventional neural implants
– Titanium package
• Highly hermetic
• MR image artifact problem
– Wire-based electrode array
• Manual fabrication, limited integration density
of contacts
• Polymer-based neural implants
– Thin & compact
– Simpler manufacturing process
• MEMS technology
– No MR image artifact
– Relatively low hermeticity than metals
10 mm
S. K. An et al., IEEE-TBME 2007.
![Page 34: Today- Oct. 31st](https://reader030.fdocuments.net/reader030/viewer/2022020704/61fb69ad41e3d152f301187f/html5/thumbnails/34.jpg)
Neural Prosthetic Engineering
Liquid Crystal Polymer (LCP)
34
• Two widely used polymers
– Polyimide, parylene-C
• Relatively high water absorption rate
• Lack of long-term reliable
• Liquid Crystal Polymer:A New Biomaterial for Implantable Devices
– Biocompatible
– Chemically inert and mechanically stable
– Flexible
– Compatible with MEMS technologies
– RF transparent
– Very Low water absorption rate (<0.04%)
– Fusion-bondable
– Deformable
LCP [1]
(Vecstar)
Polyimide [2]
(PI2525)
Parylene-C [3]
(GALXYL)
Melting Temp. (°C) 280~335 >400 290
Tensile Strength
(MPa)270~500 128 69
Young’s Modulus
(GPa)2~10 2.4 3.2
Water absorption (%)
< 0.04 2.8 0.06 ~ 0.6
Dielectric Constant
(@1MHz)2.9 3.3 2.95
[1] Kuraray group, http://www.kuraray.co.jp/en/[2] HDMicroSystems, http://hdmicrosystems.com/HDMicroSystems/en_US/[3] V&P Scientific, Inc., http://vp-scientific.com/parylene_properties.htm
![Page 35: Today- Oct. 31st](https://reader030.fdocuments.net/reader030/viewer/2022020704/61fb69ad41e3d152f301187f/html5/thumbnails/35.jpg)
Neural Prosthetic Engineering
LCP-Based Cochlear Implant
35
![Page 36: Today- Oct. 31st](https://reader030.fdocuments.net/reader030/viewer/2022020704/61fb69ad41e3d152f301187f/html5/thumbnails/36.jpg)
Neural Prosthetic Engineering
Electronics Design
36
• Simplified circuit block diagram
Contact pad sideCoil side
Fabricated electronic board
for cochlear implant
[1] S. K. An et al., IEEE TBME 2007.
Current stimulator chip
0.8 μm high voltage CMOS process (AMS)
CIS strategy
16 ch. mono- & 15 ch. bi-polar stimulation
Stimulation rate : 1,000 pps/channel
Duration : 0 μs ~ 56 μs
(7 levels, 8 μs step)
Amplitude : 0 μA ~ 1.8 mA
(255 levels, 7.3 μA step )
[2] J. Jeong et al., Conf Proc IEEE Eng Med Biol Soc 2011.
• Fabricated on Copper clad LCP film
– Planar type receiving coil integration for low-cost & miniaturized cochlear implant
![Page 37: Today- Oct. 31st](https://reader030.fdocuments.net/reader030/viewer/2022020704/61fb69ad41e3d152f301187f/html5/thumbnails/37.jpg)
Neural Prosthetic Engineering
• LCP-based Cochlear Implant System
Small & Light Package
37
[1] S. K. An et al., IEEE-TBME 2007.
Parameter Value
Carrier Frequency 2.5 MHz
Operating Distance 12 mm
Current Amplitude 8 μA~1.8 mA
Pulse Duration* 0~56 μs
Pulse Rate* Total 8,000 Hz
Parameter *LCP-based CI Titanium-based CI[1]
Package Size 20 x 28 mm2 65.7 x 33.3 mm2
Package
Max. thickness
(w/o magnet)
1.2 mm 8.2 mm
Weight
(w/o magnet)0.45 g 10.4 g
1. Physical Dimension (LCP vs. Ti-based CI)
2. Wireless & Stimulation* LCP-based
cochlear
implant
Metal-based
cochlear implant [1]
![Page 38: Today- Oct. 31st](https://reader030.fdocuments.net/reader030/viewer/2022020704/61fb69ad41e3d152f301187f/html5/thumbnails/38.jpg)
Neural Prosthetic Engineering
Flexible LCP-Based Cochlear Electrode Array
38
• LCP-based cochlear electrode array
– Multi-layered & tapered LCP film structure
– Sawtooth-like structure
– Silicone elastomer encapsulation• Minimal insertion force
• Atraumatic insertion
Cross Section of
16-Channel Interconnection
`
`
`
`
300
35
0
25
50
75
750
57
5
LCP Substrate
First LCP Cover
Second LCP Cover
Multi-layered Lead Wires
Via
Unit: μm
[1] K. S. Min et al., Otology & Neurotology 2014.[2] T.M. Gwon et al., Biomedical Microdevices 2015.
SitesE-Gun Deposited/Electroplated
Blind Via
Side Via Opening
Lead Wires38
![Page 39: Today- Oct. 31st](https://reader030.fdocuments.net/reader030/viewer/2022020704/61fb69ad41e3d152f301187f/html5/thumbnails/39.jpg)
Neural Prosthetic Engineering
Evaluation – Human Temporal Bone Insertion Study
39
• Safety validation of the electrode
– Human temporal bone insertion test
– Insertion depth measurement from CT scan image of the temporal bone
• No trauma at basal turn
• Dislocation into scala vestibule at middle turn in 630°insertion trial
• Max. insertion depth: ~630°
Cochlear electrode
[1] T.M. Gwon et al., Biomedical Microdevices 2015.
CT scan images (▲ )and
cross-section (▼) of the temporal bones
(round window approach:
insertion depth ~ 630°)
CT scan images (▲ )and
cross-section (▼) of the temporal bones
(cochleostomy approach:
insertion depth ~ 500°)
SV: Scala vestibuliST: Scala tympani
SV
SVSV
STST
ST
ST
STST
SV
SVSV
![Page 40: Today- Oct. 31st](https://reader030.fdocuments.net/reader030/viewer/2022020704/61fb69ad41e3d152f301187f/html5/thumbnails/40.jpg)
Neural Prosthetic Engineering
MRI Compatibility and In Vivo Functionality Testing
40
• Results of the 3.0 T MRI experiments
– Metal-based CI: Severe MR image artifact
– LCP-based CI: Little MR image artifact
50 mm
Axial Coronal
* *
3.0 T MR images of the head
[1] J. H. Kim et al., Clin Exp Otorhinolaryngol 2010.
• LCP-based Cochlear Implant
– EABR measurement
0 2 4 6 8-6
-4
-2
0
2
4
6
Vo
ltag
e (
V)
Time (ms)
Measured eABR
Wave V
Stimulus artifact
Package
Electrodes
Stimulation:
800 μA, 32 μs
(EABR: electrically evoked auditory
brainstem response)
![Page 41: Today- Oct. 31st](https://reader030.fdocuments.net/reader030/viewer/2022020704/61fb69ad41e3d152f301187f/html5/thumbnails/41.jpg)
Neural Prosthetic Engineering
Long-Term Reliability of LCP
41
• Accelerate Soak Test in 75℃ Phosphate Buffered
Saline (PBS) Solution
• Multi-Interdigitated Electrode (IDE) array
• Long-term leakage current measurements of polyimide, parylene-C, and LCP.
[1] SW Lee et al., IEEE-TBME 20110 15 30 45 60 75 90 105 120 135 15010
-13
10-12
10-11
10-10
10-9
10-8
10-7
10-6
10-5
10-4
10-3
10-2
Soak Time (days)
Cu
rren
t (A
)
Polyimide
Ch1
Ch2
Ch3
Ch4
Ch5
Ch6
0 15 30 45 60 75 90 105 120 135 15010
-13
10-12
10-11
10-10
10-9
10-8
10-7
10-6
10-5
10-4
10-3
10-2
Soak Time (days)
Cu
rren
t (A
)
Parylene-C
Ch1
Ch2
Ch3
Ch4
Ch5
Ch6
0 30 60 90 120 150 180 210 240 270 300 330 360 390 420 450 48010
-13
10-12
10-11
10-10
10-9
10-8
10-7
10-6
10-5
10-4
10-3
10-2
Soak Time (days)C
urr
en
t (A
)
LCP
Ch1
Ch2
Ch3
Ch4
Ch5
Ch6
Mean time to failure
> 1 year (380 days)
0 15 30 45 60 75 90 105 120 135 15010
-13
10-12
10-11
10-10
10-9
10-8
10-7
10-6
10-5
10-4
10-3
10-2
Soak Time (days)
Cu
rren
t (A
)
Polyimide
Ch1
Ch2
Ch3
Ch4
Ch5
Ch6
0 15 30 45 60 75 90 105 120 135 15010
-13
10-12
10-11
10-10
10-9
10-8
10-7
10-6
10-5
10-4
10-3
10-2
Soak Time (days)
Cu
rren
t (A
)
Parylene-C
Ch1
Ch2
Ch3
Ch4
Ch5
Ch6
0 30 60 90 120 150 180 210 240 270 300 330 360 390 420 450 48010
-13
10-12
10-11
10-10
10-9
10-8
10-7
10-6
10-5
10-4
10-3
10-2
Soak Time (days)
Cu
rren
t (A
)
LCP
Ch1
Ch2
Ch3
Ch4
Ch5
Ch6
0 15 30 45 60 75 90 105 120 135 15010
-13
10-12
10-11
10-10
10-9
10-8
10-7
10-6
10-5
10-4
10-3
10-2
Soak Time (days)
Cu
rren
t (A
)
Polyimide
Ch1
Ch2
Ch3
Ch4
Ch5
Ch6
0 15 30 45 60 75 90 105 120 135 15010
-13
10-12
10-11
10-10
10-9
10-8
10-7
10-6
10-5
10-4
10-3
10-2
Soak Time (days)
Cu
rren
t (A
)
Parylene-C
Ch1
Ch2
Ch3
Ch4
Ch5
Ch6
0 30 60 90 120 150 180 210 240 270 300 330 360 390 420 450 48010
-13
10-12
10-11
10-10
10-9
10-8
10-7
10-6
10-5
10-4
10-3
10-2
Soak Time (days)
Cu
rren
t (A
)
LCP
Ch1
Ch2
Ch3
Ch4
Ch5
Ch6
Mean time to failure
: 75 days
Mean time to failure
: 115 days
Polyimide Parylene-C LCP
![Page 42: Today- Oct. 31st](https://reader030.fdocuments.net/reader030/viewer/2022020704/61fb69ad41e3d152f301187f/html5/thumbnails/42.jpg)
Neural Prosthetic Engineering
Optical Stimulation
42
• Introducing Optics in cochlear implantation
• Multichannel Optical Cochlear Implantation
– Highly local stimulation
– Fine frequency resolution
– Increasing the number of effective channels
– Limited by line-of-sight property of light, and added complexity in optical instrumentation
Optical stimulation of auditory neurons: effects of acute and chronic deafening.
Richter CP, Bayon R, Izzo AD, Otting M, Suh E, Goyal S, Hotaling J, Walsh JT
Hearing research 2008 Aug; 242(1-2):42-51
http://openoptogeneticsblog.org/?p=682
![Page 43: Today- Oct. 31st](https://reader030.fdocuments.net/reader030/viewer/2022020704/61fb69ad41e3d152f301187f/html5/thumbnails/43.jpg)
Neural Prosthetic Engineering
Reference
• J. Jeong et al., Conf Proc IEEE Eng Med Biol Soc 2011.
• S. K. An et al., IEEE-TBME 2007.
• T.M. Gwon et al., Biomedical Microdevices 2015.
• K. S. Min et al., Otology & Neurotology 2014.
• A.A.Eshraghi (The Anatomical Record, 2012)
• B. S. Wilson & M. Dorman (Hearing Research, 2008)
• Ducci et al., Otology & Neurotology, 2010
• J.Wang and K.D.Wise, J.MEMS 2008.
• C.-P. Richter et al., Hearing Research, 2008
• L.E.Moreno et al., Hearing Research 2011.
• M. Jeschcke et al., Hearing Research 2015.
43