Meat Community Supported Agriculture (CSA) Feasibility Study
This study is supported by Tubitak.
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Transcript of This study is supported by Tubitak.
Abstract: Effective control of the pharmaceutical tablets is of great importance. This study that is based on terahertz spectroscopy aims to develop a fast, active, and non-destructive material characterization method. Terahertz Spectroscopy allow a structural analysis in a wide scan range of 5 to 700 cm-1. In this study, active pharmaceutical ingredients that are used in commercial drugs are characterized using fingerprint spectra in 30-700 cm-1 range by THz-FTIR Spectroscopy.
This study is supported by Tubitak.
EXPERIMENTAL
Active pharmaceutical powders are ground in an agate mortar without further purification Specified amount of the particles is mixed with high density polyetylene and compressed into a 1.3 cm diameter pellet with a pressure of 2 tons for 5 minutes. Prepared pellets are directly placed in the sample compartment of the THz-FTIR instrument.
References
1. Ajito, K.; Ueno Y.; Song H., NTT Technical Review, 2012 ,10(2) 2. Taday, P. F., Phil. Trans. R. Soc. London, 2004, 362, 351-364
RESULTS AND DISCUSSION
Terahertz Time DomainSpectrometer (THz-TDS)
Terahertz Generation
Crystal
SAMPLE
Wollaston Prism
Ti:Sapphire Laser
Broadband Dielectric Mirror Beam
Splitter
Beam Combiner
Cubic Mirror
Parabolic Mirror
Terahertz Detection Crystal
Working range: 5-150 cm-1
THz Generation and Detection Crystal: ZnTe, 1mm
MEASUREMENT OF MATRIX MATERIALS
700 600 500 400 300 200 1000,0
0,2
0,4
0,6
0,8
Abso
rban
ce
Wavenumber (cm-1)
5 mg Benzydamine in 50 mg HDPE
186.10
83.89
700 600 500 400 300 200 1000,0
0,1
0,2
0,3
0,4
0,5
0,6
0,7
50 mg pure Ibuprofen
5 mg Ibuprofen in 50 mg HDPE
Abso
rban
ce
Wavenumber (cm-1)
114.75217.92269.02
334.11
0
1
2
3
4
5
6
MEASUREMENT OF ACTIVE PHARMACEUTICALS
Terahertz absorption images(commercial and test tablets)4
Tablet surface ingredient distribution (near-IR imaging)1
Infrared
1014101310121011
Microwaves Terahertz
1010109
Hz
→ low energy waves → non-destructive → penetrate into the material→ transmit through nonpolar molecules (plastic, ceramics)
1 THz = 1ps, 300 μm, 33 cm-1 , 4.1 meV, 47.6 K
600 300 00
20
40
60
Ampli
tude
Wavenumber (cm-1)
HDPE(Sigma A)_50mg HDPE (Sigma A)_100mg HDPE (Petkim)_100mg Wheat Starch_20mg
Absorbance Spectra
300 250 200 150 100 500
1
2
3
Abso
rban
ce
Wavenumber (cm-1)
Wheat Starch_20 mg HDPE (Petkim)_100mg HDPE (SA)_50mg HDPE (SA)_100mg
Raw Spectra
HDPE transmission in Far-IR region is very high due to its nonpolar characteristic.Therefore, HDPE forms a good matrix to disperse the active material.
For easier comparison, the spectra are offset by one absorbance unit.
700 600 500 400 300 200 100-1,0
-0,5
0,0
0,5
1,0
1,5
2,0
Abso
rban
ce
Wavenumber (cm-1)
Naproxen Benzydamine Ibuprofen
1. Benzydamine 2. Ibuprofen
3. Naproxen
CONCLUSION Strong absorption peaks are observed in THz region. THz waves can be used as a tool to characterize active pharmaceuticals. There are sufficient differences between the three active pharmaceuticals to make it possible to use for identification.
FUTURE DIRECTIONS Measurement of samples with THz-TDS Assay of active pharmaceuticals in tablets Investigation of tablet homogeneity
MERVE DOĞANGÜN, ENİS ARIK, OKAN ESENTÜRKChemistry Department, Middle East Technical University, 06800 Çankaya, Ankara
[email protected]; [email protected]
Laser Spectroscopy
Group
METHOD DEVELOPMENT FOR ACTIVE PHARMACEUTICAL INGREDIENT ANALYSIS IN TERAHERTZ REGION
http://www.shutterstock.com/pic-2845058/
INTRODUCTION
The THz-waves provide important information about the low-frequency vibrational modes including hydrogen bonding, rotational modes of gases and crystal phonon modes.1
Intensity Absorbance
APPLICATIONS
BIOTECHNOLOGY 2
•Determination of high order protein structures•Genetic sensing•Biomedical Imaging
PHARMACEUTICS 2
•Characterisation of tablet coating & polymorphism•Inspection of tablet core Integrity
SECURITY 3
•Illicit Drug & Explosive Detection•Inspection of biological and chemical agents
BB Source
Beam Splitter
Delay Stage
SAMPLE
Detector
Working range: 30-700 cm-1
Source: ETCBeam Splitter: DTGS-PE
Thermo Scientific Nicolet 6700 FTIR Spektrometer
Central λ: 800nm
700 600 500 400 300 200 1000,0
0,2
0,4
0,6
0,8 5 mg Naproxen in 50 mg HDPE
Abso
rban
ce
Wavenumber (cm-1)
214.54
0,0
0,5
1,0
1,5
2,0
2,5
3,0
3,5
50 mg pure Naproxen
3. Kemp, M. C.; Taday, P. F.; Cole, B. E.; Cluff J. A.; Fitzgerald, A. J.; Tribe, W. R., Proc of SPIE, 2003, 5070, 84. Application of imaging analysis technology http://www.ds-pharma.com/rd/drug_discovery/product.html