There’s something biobrilliant in the air… · manual hand dispenser offer automatic tip...

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There’s something biobrilliant in the air…

Transcript of There’s something biobrilliant in the air… · manual hand dispenser offer automatic tip...

Page 1: There’s something biobrilliant in the air… · manual hand dispenser offer automatic tip recognition combined with an automatic volume calculation. The positive displacement system

There’s something

biobrilliant in the air…

Page 2: There’s something biobrilliant in the air… · manual hand dispenser offer automatic tip recognition combined with an automatic volume calculation. The positive displacement system

Bioascend.Achieve stellar research results with

cell lines shaped for your research.

Get your hands on disease model, reporter or

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using CompoZr® ZFN technology from

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wherebiobegins.com/biocells

biocells

CompoZr and Sigma are registered trademarks of Sigma-Aldrich

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Page 3: There’s something biobrilliant in the air… · manual hand dispenser offer automatic tip recognition combined with an automatic volume calculation. The positive displacement system

R&D Systems, Inc. www.RnDSystems.com

R&D Systems Europe, Ltd. www.RnDSystems.co.uk

R&D Systems China Co., Ltd. www.RnDSystemsChina.com.cn

For research use only. Not for use in diagnostic procedures.

Cancer

Development

Endocrinology

Glycobiology

Immunology

Neuroscience

Proteases

Signal Transduction

Stem Cells

For more information visit our website at www.RnDSystems.com/go/Neuroscience

R&DSystems o�ers awide range of high quality products for neuroscience research. In addition to high performance

antibodies, we o�er the most referenced collection of premium quality proteins and ELISA kits in the industry.

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Neuroscience ResearchR&D Systems Products for

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Performance.

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Plexin-B2 Notch-2 O4

RGM-B HSPH1

GFAP BSRP-A Vanilloid R1

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GE HealthcareLife Sciences

Label-free analysis using Biacore and MicroCal systems provides

comprehensive characterization of biomolecular interactions and

biomolecule stability. The information-rich data enables key insights

into the biological processes and molecular binding mechanisms

crucial to your research. Equipped with the right information,

you can make speedy, smart decisions with confidence.

Visit www.gelifesciences.com/interactions

Confidencethat comeswith the rightinteractions.

Biacore™ & MicroCal™

Biacore systems MicroCal DSC and iTC

Biacore and Microcal are trademarks ofGE Healthcare companies.© 2010 General Electric Company – All rights reserved.GE Healthcare Bio-Sciences AB, Björkgatan 30,751 84 Uppsala, Sweden

GE05-10. First published April 2010.

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Sample & Assay Technologies

AU

TO

Portf0

110S1W

W

Automated solutions from sample to result:

■ The widest choice of sample processing protocols

■ Low-, medium-, and high-throughput automation

■ Leading solutions for molecular diagnostics

■ Plug-and-play automated sample preparation

■ Quantitative, real-time PCR detection

■ Automated analysis of DNA fragments and RNA

■ High-resolution sequence-based DNA detection and quantification

■ HPV testing

Making improvements in life possible — www.qiagen.com

Automated sample and assay technologies

by QIAGEN

Free up your time

Page 6: There’s something biobrilliant in the air… · manual hand dispenser offer automatic tip recognition combined with an automatic volume calculation. The positive displacement system

Because science never stands still.Introducing the FREE Mobile App from Science. See what it can do for you.

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Page 7: There’s something biobrilliant in the air… · manual hand dispenser offer automatic tip recognition combined with an automatic volume calculation. The positive displacement system

Over

30 years of

experience

Performing for excellence

Serial dispensing at its best: Repeater®

The Eppendorf Repeater handheld dispensing system

offers an outstanding range of benefits:

Together with Combitips plus®, both the electronic and

manual hand dispenser offer automatic tip recognition

combined with an automatic volume calculation.

The positive displacement system ensures high-precision

dispensing for all kinds of liquids including volatile and

viscous solutions. 9 different sizes of tips offer a volume-

range from 1 µL – 50 mL.

Easy volume setting

‡ Repeater plus: 1 µL – 10 mL

‡ Repeater stream/Xstream: 1 µL – 50 mL

Up to 100 dispensing steps without stopping

‡ Repeater plus:

20 different adjustable volumes per tip

‡ Repeater stream/Xstream:

1,000 different adjustable volumes per tip

For more information visit www.eppendorf.com/mpplus

or www.eppendorf.com/mpxstream

‡ Electronic

dispensing

‡ Positive

displacement tips

‡ Manual

dispensing

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Your local distributor www.eppendorf.com/worldwide · Application Support E-mail: [email protected]

Eppendorf AG · Hamburg · Germany · Tel: +49 40 538 01-0 · Eppendorf North America, Inc. · USA · Tel: +1 800 645 3050 menu option 2

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526 22 OCTOBER 2010 VOL 330 SCIENCE www.sciencemag.org/products

NEW PRODUCTS

LIFE SCIENCE TECHNOLOGIES AAAS/Science Business Office

Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are

featured in this space. Emphasis is given to purpose, chief characteristics, and availability of products and materials. Endorsement by Science or AAAS of any products or

materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

Electronically submit your new product description or product literature information! Go to www.sciencemag.org/products/newproducts.dtl for more information.

THERMAL CYCLERThe TOptical thermocycler combines state of the art technology with

a functional design to deliver maximum fl exibility. The instrument

provides excellent temperature uniformity and high speed due to

the excellent heat conductivity of the silver block. Existing TProfes-

sional thermocyclers can be upgraded with the TOptical module to

a complete real-time polymerase chain reaction (qPCR) instrument.

The TOptical thermocycler can be equipped with up to six excitation

and emission fi lters of choice that allow the detection of commonly

used real-time PCR dyes. The fi lters are easily interchangeable and

retrofi ttable. Excitation of fl uorophores by long-living LEDs allows

PCR reactions to be monitored in real-time with high specifi city and

lowest detection limits. The system’s intuitive, easy-to-use software

offers several tools for data analysis, as well as data export func-

tions for further data analysis with programs such as Excel, qBase,

Biogazelle, or REST.

Biometra GmbH

For info: +49-(0)-36-41-77-94-74 www.bio.analytik-jena.de/en/

Life-Science__3692

AUTOMATED LIQUID HANDLING The new Versette automated liquid handler is compatible with 19

interchangeable, RFID-tagged pipetting heads and provides excep-

tional pipetting versatility for a broad range of applications that re-

quire single- to 384-channel automated pipetting. The Versette is

compatible with both disposable and fi xed-tip pipetting heads, with

a total volume ranging from 0.1 µl to 1250 µl. The easy to swap two-

and six-position stages provide fl exibility for both stand-alone and

robot-friendly use. With a compact footprint, further facilitated by the

unique dual-level design of the six-position stage, the Versette can

be placed exactly where it is needed, making it ideal for use on any

benchtop or in an enclosure. Simple and complex pipetting proce-

dures can be programmed quickly and easily via the intuitive onboard

LCD user interface or the Thermo Scientifi c ControlMate software.

Thermo Scientifi c

For info: 800-345-0206 www.thermoscientifi c.com/versette

VACUUM UV SPECTROMETERThe vacuum ultraviolet spectrometer, Model 234/302, is now available

with improved effi ciency over a wide wavelength range. New plati-

num coated gratings are ideal for use at windowless wavelengths,

shorter than 120 nanometers (>10eV). The compact 200 mm focal

length spectrometer can be supplied with various gratings to spread

optimization over the entire 30 nm to 550 nm wavelength range; an

advantage allowed by the optical design. In combination with win-

dowless, sensitive, cooled, scientifi c grade CCD detectors, adjust-

able slits, and f/4.5, the McPherson Model 234/302 provides fast,

sensitive data collection. Extreme and vacuum ultraviolet radiation

and emission spectra can be analyzed with sub-nanometer spectral

resolution. Adjustable slit width provides for best light throughput

and for better spectral resolution to resolve closely spaced spectral

lines. Furnished with spectral calibration certifi cate, the McPherson

spectrometer is available with standard light sources, refl ective con-

denser optics, and vacuum differential sections.

McPherson, Inc.

For info: 978-256-4512 www.McPhersonInc.com

IgG PURIFICATION KIT

The Pearl IgG Purifi cation Kit allows for the one-step purifi cation

of IgG antibodies from serum. The kit is supplied with Pearl IgG

Purifi cation Resin which binds non-IgG proteins (i.e. albumin) and

allows the desired IgG molecules to pass through to a physiologi-

cal buffer. Purifi ed IgG can then be stored or used downstream in

further applications. The Pearl IgG Purifi cation kit segregates IgG

in less than fi fteen minutes with a purity of 90 percent. The per-

formance of this kit is more rapid than commonly used Protein

A or Protein G purifi cation resins. The Pearl IgG Purifi cation Kit is

offered in a small scale spin format for purifi cation of 25 mg IgG

and a larger format for purifi cation of ~200 mg IgG from ~100 mL

of serum.

G-Biosciences

For info: 800-628-7730 www.gbiosciences.com

SYRINGE PUMP

Legato syringe pumps are an economical solution for delivering precise and

smooth fl ow in research, pilot plants, and production applications. The new Le-

gato 270 Syringe Pump has an optimized user confi gurable syringe mechanism

designed to uniquely deliver a full volume in infuse and withdraw modes wheth-

er using small or large syringes. This reconfi gurable mechanism allows the user

to change the syringe clamping mechanism to hold from 0.5 µl up to 140 ml

syringes. The Legato 270 features a continuous push and pull pump, which when

used with check valves will draw fl uid from a reservoir while the opposite side is

dispensing fl uid and after the user selected volume is dispensed, the pump will

automatically switch through the check valves and refi ll the empty syringes while

dispensing from the other side. Flow performance is optimized with a small step

angle stepping motor that drives a precision lead screw. Accuracy is ±0.35 per-

cent and has 0.05 percent reproducibility.

Dorton Analytical Ltd.

For info: +44-(0)-7872-520670 www.dortonanalytical.co.uk

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Call forPapers Science

SignalingScience Signaling, from the publisher of

Science, AAAS, features top-notch, peer-

reviewed, original researchweekly. Submit

yourmanuscripts in the following areas of

cellular regulation:

Submit your research at:www.sciencesignaling.org/about/help/research.dtl

Chief Scientific Editor

Michael B. Yaffe, M.D., Ph.D.Associate Professor, Department of Biology

Massachusetts Institute of Technology

Editor

Nancy R. Gough, Ph.D.AAAS

Subscribing to theweeklyScience Signalingensures that you and your lab have the latestcell signaling resources. For more information

visitwww.ScienceSignaling.org

• Biochemistry

• Bioinformatics

• Cell Biology

• Development

• Immunology

• Microbiology

• Molecular Biology

• Neuroscience

• Pharmacology

• Physiology and

Medicine

• Systems Biology

Science Signaling is indexed in CrossRef

andMEDLINE.

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www.neb.com

CLONING & MAPPINGDNA AMPLIFICATION

& PCRRNA ANALYSIS

PROTEIN EXPRESSION

& ANALYSIS

GENE EXPRESSION

& CELLULAR ANALYSIS

UNDERSTANDING CHANGE

New tools to advance epigenetics researchFor over 35 years, New England Biolabs has been committed to understanding the mechanisms of restriction and

methylation of DNA. This expertise in enzymology has recently led to the development of a suite of validated

products for epigenetics research. These unique solutions to study DNA methylation are designed to address some

of the challenges of the current methods. EpiMark™ validated reagents simplify epigenetics research and expand the

potential for biomarker discovery.

EpiMark™ validated products include:

• Newly discovered methylation-dependent restriction enzymes

• A novel kit for 5-hmC and 5-mC analysis and quantitation

• Methyltransferases

• Histones

• Genomic DNAs

To learn how these products can help you to better

understand epigenetic changes, visit neb.com/epigenetics.

Simplify DNA methylation analysis with MspJI

MspJI recognizes methylated and hydroxymethylated DNA and cleaves

out 32 bp fragments for sequencing analysis. Overnight digestion of

1 µg of genomic DNA from various sources with or without MspJI is

shown. Note: Yeast DNA does not contain methylated DNA, therefore

no 32-mer is detected.

Plant

Hela (Maize) Yeast

– + – + – + MspJI

32 bp