Therapeutic Plasma Exchange for Myasthenia Gravis Clifford Blieden, MD Houston Methodist Hospital...
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![Page 1: Therapeutic Plasma Exchange for Myasthenia Gravis Clifford Blieden, MD Houston Methodist Hospital Department of Pathology and Genomic Medicine, Division.](https://reader038.fdocuments.net/reader038/viewer/2022103022/56649d225503460f949f8449/html5/thumbnails/1.jpg)
Therapeutic Plasma Exchange for Myasthenia GravisClifford Blieden, MD
Houston Methodist HospitalDepartment of Pathology and Genomic Medicine, Division of Transfusion Medicine
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Who Are We?• Physicians with residency training in Clinical Pathology with or
without Anatomic Pathology• Fellowship trained in Transfusion Medicine• WE TAKE CALL!!!!
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Myasthenia Gravis• Neuromuscular disorder caused by circulating autoantibodies
to the acetylcholine receptors in the post synaptic neuromuscular junction
• Associated with a variety of other autoimmune diseases such as Hashimotos thyroiditis, type I diabetes, lupus
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Common Modalities for Diagnosing Myasthenia Gravis• Serologic testing• Acetylcholine receptor antibodies• Muscle specific (MuSK) receptor antibodies
• 50% of seronegative MG patients may have antibodies to MuSK
• Muscle electromyography• Edrophonium (cholinesterase inhibitors) test• Muscle biopsy • IgG deposition at neuromuscular junction by
immunofluorescence
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Current Treatment Options• Medications:• Increase acetylcholine (cholinesterase inhibitors; neostigmine,
pyrostigmine)• Decrease immune response (corticosteroids)
• Plasma exchange to remove antibodies• Thymectomy• Thymoma and MG are frequently associated
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Plasmapharesis• Word is derived from “plasma” and Greek word “aphaeresis”
(take away)• Blood is removed from the body and separated into separate
components (plasma and red cell component)• Continuous process requiring an afferent and efferent site of
blood supply.
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Why Plasma Exchange?• Antibodies reside in the plasma component of the blood• Removal of these antibodies temporarily decreases symptoms
of myasthenia gravis• Scheduled plasma exchange regimen useful in patients with
disease not helped by medications
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TPE and Myasthenia Gravis• TPE is used to remove antibodies present in the plasma
component• May be applied in multiple settings (outpatient, inpatient,
perioperative) • Regarded as a category I indication (ASFA guidelines)• Category I = disorders for which apheresis is accepted as first
line therapy, either alone or in conjunction with other treatment modalities
• Patients MAY experience improvement of symptoms within 24 hours
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Common side effects of plasma exchange• Paresthesia• Hypotension • Urticaria• Nausea• Abdominal cramps
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Hypocalcemia• Common occurrence with plasma exchange due to citrate, an
anticoagulant necessary to prevent blood from clotting during the exchange
• Citrate binds ionized calcium, hence hypocalcemia occurs• Symptoms include perioral tingling, numbness• Treated with IV or oral calcium supplementation
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Hypotension• Occurs in some patients• Usually mild• Important not to take certain blood pressure medications
prior to plasma exchange (ACE inhibitors)