The world’s biggest health problem…

How Big is the Problem?

“Healthcare

expenditures on

diabetes are

expected to

account for

11.6% of the total

healthcare

expenditure in the

world in 2010.” http://www.diabetesatlas.org/

content/economic-impacts-

diabetes below http://aadi.joslin.org/content/asian/di

abetes-complications-asians 3-9-11

1 in 9

Sick

Care

Dollars

“Using World Health

Organization (WHO)

figures on years of

life lost per person

dying of diabetes,

this translates into

more than 25 million

years of life lost

each year.” http://www.idf.org/node/1081?unode=3B

9691D3-C026-2FD3-87B7FA0B63432BA3

below

Diabetes increases death rate

1.80x any cause,

1.25x cancer,

2.32x vascular causes,

and 1.73x other causes.” NEJM 364;9 march 3, 2011 abstract below

www.diabeteswellbeing.com/can-you-die-from-diabetes.html

“Diabetes

confers an

equivalent

risk to

ageing 15

years.” The Lancet 2006; 368:29-36 Below

*

“people who have type I diabetes are unable to

produce the insulin signal…the cells of type II diabetics have lost the ability to respond to insulin

http://learn.genetics.utah.edu/content/begin/cells/badcom/

No signal vs

no response

“In normal conditions, β-cell

maintenance relies on their long

lifespan, as they proliferate little 5,6. In

response to increased physiological

demand, there is increased β-cell

proliferation 7,8. If the

β-cell mass decreases

below certain critical

levels (around 10% of the

normal values 9), there is

diabetes onset; (T1D)” Nature. 2010 April 22; 464(7292): 1149–

1154. PMCID: PMC2877635 abstract

below

3-8-11

http://stemcell

s.nih.gov/info/

scireport/cha

pter7.asp

Pancreas 10X reserve capacity

Target Beta Cells that

are Functional but

not functioning…

“There is a progressive deterioration in beta-cell function and

mass in type 2 diabetics. It was found that islet function was

about 50% of normal at the time of diagnosis and a reduction

in beta-cell mass of about 60% was shown at necropsy.” Endocr Rev. 2007 Apr;28(2):187-218. Epub 2007 Mar 12. PMID: 17353295 below

http://www.lantus.com/hcp/insulin-and-diabetes.aspx

50%

lo

ss

Can 50% be

enough IF you

have 10x

reserve?

The 3 main pathophysiological

defects of Type 2 diabetes β-cell

dysfunction Insulin-

resistance

Increased hepatic glucose

production

http://www.cardiodiabetesmc.org/default.aspx?id=12&subId=27&presentationId=28 3-13-11

W to Ht > 0.5

Progression of

Insulin Resistance Nature Medicine 12, 41 -

42 (2006)Below

NOTE: Insulin resistance occurs in

different tissues (Muscle, Liver, Fat) at different rates in

different people. Empty Calories

1? 2? 3?

“There is nothing more difficult to carry out, nor more doubtful of success, nor more

dangerous to handle, than to initiate a new order of things. For the reformer has enemies in

all those who profit by the old order, and only lukewarm defenders in all those who would

profit by the new order” “The basic fact is that one third of our economy profits from

making people sick and fat. The food industry sells products scientifically proven to kill

more people than cigarettes, while our health care industry profits from providing more

volume of care focused on medication and procedures, not better health.” http://drhyman.com/blog/2012/09/06/money-politics-and-health-care-a-disease-creation-economy-part-i/

“the reformer has enemies in all those who profit by the old order”

$280K

per year

What does

insulin do?

© Rakowski 2008

“Despite overwhelming

evidence on the damaging

consequences of oxidative

stress and its role in

experimental diabetes,

large scale clinical trials with classic

antioxidants failed to demonstrate any

benefit for diabetic patients.”

“a more comprehensive

approach aimed at preventing

the generation of these

reactive species as well as

scavenging may prove more

beneficial.” Cardiovasc Diabetol. 2005; 4: 5.

Article below

“Catherine Bowers of Rockingham,

N.C., with some of her medications.”

August 20, 2007

below

Similar to Mark

Hyman’s patient

who was a diabetic

educator with out of

control diabetes

and polypharmacy.

Mark Hyman,

Lifestyle Summit

9-29-12

“Kaplan–Meier

analysis showed a

cumulative

incidence of

monotherapy

failure at 5 years of 15% with

rosiglitazone,

21% with

metformin,

and 34% with

glyburide.” NEJM 355;23 www.nejm.org

december 7, 2006 2427

below

They did not tell me that

the drugs would stop

working . . .

“an intensive therapeutic approach targeting

normal glycated hemoglobin levels with the

use of multiple medications is associated with

higher mortality than is a standard approach” N Engl J Med. 2011 Mar 3;364(9):818-28. PMID: 21366473 below

“Type 2 diabetes has long been regarded

as a chronic progressive condition,

capable of amelioration but not cure.” Diabetologia. 2011 October; 54(10): 2506–2514. PMCID: PMC3168743 below

There is no

cure for type

2 Diabetes.

I’m sorry.

“Bariatric Surgery is known to be the most effective and long lasting

treatment for morbid obesity and many related conditions, but now

mounting evidence suggests it may be among the most effective

treatments for metabolic diseases and conditions including type 2

Diabetes, hypertension, high cholesterol, non-alcoholic fatty liver disease

and obstructive sleep apnea”

http://www.asbs.org/Newsite07/patients/benefits.htm

“We can cure your diabetes by surgically reducing the size of your stomach by 90%.”

http://www.newsfirst5.com/news/obesity-linked-to-asthma-risk/ 3-13-11

Intense week

short term

easy to do,

you have nothing to lose,

the results can be

dramatic,

slow and steady

rarely creates this

type of change

Mark Hyman, FMU 7-2012

track g ‘My intense diet is like a Gastric Bypass but without the pain,

nausea, vomiting and malnutrition.’ Mark Hyman 9-29-12

1 Week Intense Detox

Unlimited Quantities of multi

colored organic vegetables

Unlimited Quantities of a specific

medical food. (UCpH, Renew)

Add Synergistic Micronutrients for

complex cases

Accessory Detox

Coffee Enemas (up to 3 per day),

Saunas etc if desired.

Week 2 – reduce the medical food

to 2 servings daily and incorporate

the full modified elimination diet.

Reboot - Control Alt Delete

“This study demonstrates that the twin defects of beta cell failure and

insulin resistance that underlie type 2 diabetes can be reversed by acute

negative energy balance alone… In the first 7 days of the reduced energy

intake, fasting blood glucose and hepatic insulin sensitivity fell to normal,

and intrahepatic lipid decreased by 30%. Over the 8 weeks of dietary

energy restriction, beta cell function increased towards normal and

pancreatic fat decreased.” Diabetologia. 2011 October; 54(10): 2506–2514. PMCID: PMC3168743 below

Among

individuals aged

70 to 90 years,

adherence to a

Mediterranean

diet and

healthful

lifestyle is

associated with

a more than 50%

lower rate of all-

causes

and cause-

specific

mortality. JAMA. 2004;292:1433-

1439 article below

Insulin tells the cells

to do the following:

Absorb glucose, fatty

acids and amino acids

Stop breaking down:

1. glucose, fatty acids and

amino acids

2. glycogen into glucose

3. fats into fatty acids and

glycerol

4. proteins into amino

acids

Start building:

1. glycogen from glucose

2. fats (triglycerides) from

glycerol and fatty acids

3. proteins from amino

acids http://health.howstuffworks.com

/human-body/cells-tissues/fat-

cell2.htm below

http://diabetesindogs.wikia.com/wiki/File:Homeos18.JPG

Store Fat Go

Before and after insulin (1923ish) http://edgeofthewest.wordpress.com/2008/10/page/2/ below

Insulin is

Anabolic and

Anticatabolic

Protein,

Fat and CHO

are all

negatively

effected

“Mr. Cutler was 24 when

he learned he had Type 1

diabetes, which was

diagnosed after a rapid

35-pound weight loss and

severe fatigue originally

attributed to stress. A

team physical finally led

to a diagnosis.”

“This process and

other research on

obesity explains

why the marker of

a Type I diabetic

diagnosis is the

rapid loss of

weight.” http://www.healthy-eating-

politics.com/research-on-

obesity.html below

-35#

“You cannot store fat in the fat cells without

the presence of insulin” http://www.healthy-eating-politics.com/research-on-obesity.html below

*

Third, blood fat rises.

Second, body fat rises. First, insulin levels rise.

(postprandiol, then fasting.)

Fourth, Glucose rises.

Progression of Dysglycemia

Diana Schwarzbein, M.D. *

“The regional fat distribution in humans is

clearly regulated by hormones, although genetic factors also play important roles.”

Hum Reprod. 1997 Oct;12 Suppl 1:21-5. PMID: 9403318 citation from page 21

Insulin Carbohydrate Intolerance

Diabetes Perfect

Storm High Body Fat (Leptin)

Visceral Fat

(inflammation, lipotoxicity)

Inactivity (Glut4) High Blood Fat (lipotoxicity)

High Blood Sugar (glucotoxicity)

Inflammation (amyloid)

Toxicity (GGT)

Glutamate

Dairy (immune reaction)

Endocr Rev. 2007

Apr;28(2):187-218. Epub 2007

Mar 12. PMID: 17353295 below

August 23, 2004

Excess Adipokines

are Pro Inflammatory,

Pro Oxidizing

(Accelerate Aging)

Oppose Insulin,

Potentiate Cortisol,

Dysregulate Immunity,

Dysregulate Appetite

Contribute to Morbidity and Mortality

“Relentless and resilient, fat cells turn out to be savvy survivors, able to multiply and thrive. They are active entities, not static globs, and

produce chemicals that cause inflammation--a chronic condition linked to heart disease, diabetes and some kinds of cancer.? BELOW

Who handles

stress better?

Who’s Brain

works better?

Heart?

Kidneys?

Immune System?

Who has a better

love life?

aging faster?

Better Fertility?

More joie de vie?

Die first? Who has more fun at

Disneyland? What if the difference were only 10#?

Pancreas?

LIver?

∼ (Approximately) 90% of individuals with type 2

diabetes are either overweight or obese (5).” Diabetes Care. 2004 Jan;27(1):155-61. PMID: 14693982 below

http://www.jci.o

rg/articles/view

/29103/figure/1

Health

y?

Muscle insulin

resistance

Liver insulin

resistance

Fat

Fat

Insulin-

resistance

Ectopic fat results

in insulin resistance

Visceral

obesity

Hyperglycemia

LIPOTOXICITY : lipid accumulation in

liver and muscle is a major cause of

insulin-resistance

http://www.cardiodiabetesmc.org/default.aspx?id=12&subId=27&presentationId=28 3-13-11

Lipid

Overflow

“The

incidence of

NAFLD (Non-

alcoholic fatty

liver disease)

in MS

(Metabolic

Syndrome)

(age 6 – 16)

patients was

84.61%

(187/221)” World J Gastroenterol.

2011 Feb 14;17(6):735-42.

PMID: 21390143 below

http://peruviannaturistasmedicines.com/fatty_liver_natural_treatment.php 3-11-11

“increased consumption of high fructose corn syrup

was associated with scarring in the liver” http://www.dukehealth.org/health_library/news/high_fructose_corn_syrup_linked_to_liver_scarring below

“WHtR > or = 0.5, the

most frequently suggested

threshold value, when added to

any two nonanthropometric

variables,

(hypertension,

hyperglycemia,

hypertriglyceridemia,

and low HDL-C).

gave a sensitivity for the

identification of a metabolic

syndrome of, respectively,

92.0% for males and

87.4% for females.” Metab Syndr Relat Disord. 2009

Oct;7(5):477-84. PMID: 19492953

below

“I’m too

short…”

*

"We live in a

toxic

environment," says Kelly Brownell,

director of the Yale

University Center for

Eating and Weight

Disorders.

"Physical activities

have been

engineered out of

day-to-day life,

and the food

environment grows

worse by the day.” http://www.time.com/tim

e/magazine/article/0,917

1,1003160,00.html below

“Recent evidence from many

laboratories has shown that a variety

of environmental endocrine

disrupting chemicals can influence

adipogenesis and obesity.” Mol Cell Endocrinol. 2009 May 25; 304(1-2): 19–29.

Let you food be your medicine?

“The available information indicates that POPs residues are present in

virtually all categories of foods, including baked goods, fruit, vegetables,

meat, poultry, and dairy products. Residues of five or more persistent

toxic chemicals in a single food item are not unusual, with the most

commonly found POPs being the pesticides DDT (and its metabolites,

such as DDE) and dieldrin.”

J Epidemiol Community Health 2002; 56: 813-817 PMCID: PMC1732058

“The Environmental Protection

Agency has monitored human

exposure to toxic environmental

chemicals since 1972 when they

began the National Human

Adipose Tissue

Survey. …

Five of what are known

to be the most toxic

chemicals were found in 100% of all samples …

Nine more chemicals were found in

91-98% of samples”:

http://drhyman.com/downloads/Toxin

s-and-Obesity.pdf

“Scientists estimate that everyone alive today

carries within her or his body at least 700

contaminants, most of which have not been well

studied (Onstot and others).” *Onstot J, Ayling R, Stanley J. Characterization of HRGC/MS Unidentified Peaks from the Analysis of Human Adipose

Tissue. Volume 1: Technical Approach. Washington, DC: U.S. Environmental Protection Agency Office of Toxic Substances

(560/6-87-002a), 1987. http://www.chemicalbodyburden.org/whatisbb.htm

"POPs (Persistent

Organic

Pollutants) link to

obesity in that they

bioaccumulate in

adipose tissue

and, as endocrine

disruptors, may

interact with obesity

in disturbing both

glucose and lipid

metabolism."26,27 (Arteriosclerosis,

Thrombosis, and

Vascular Biology. 2008;28:e26.) below

Diabetologia. 2007 Dec

11; : PMID 18071669

Persistent Organic Pollutants

“obesity and

diabetes have

joined the list of

adverse effects

that have been

associated with

developmental

exposure to

environmental

estrogens and

other endocrine-

disrupting

chemicals.” Am J Clin Nutr. 2011

Dec;94(6 Suppl):1939S-

1942S. PMID: 22089436

below

“Conclusions Urinary

BPA concentration

was significantly

associated with

obesity in this cross-

sectional study of

children and

adolescents.

Explanations of the

association cannot

rule out the possibility

that obese children

ingest food with

higher BPA content or

have greater adipose

stores of BPA.” JAMA.

2012;308(11):1113-1121. below

Obesogens are “in the scientific press” with greater prominence

“Serum

concentrations of

most POPs were

higher in those

with long-term

weight loss,

whereas they were

lower in those

with long-term

weight gain.” Int J Obes (Lond). 2011

May;35(5):744-7. PMID: 20820170

below

Promoting Weight loss without

Supporting Detox is Malpractice!

“The levels of GGT compared with type 2 diabetics was found

to be significantly increased when compared with BMI,

waist/circumference, cholesterol, triglycerides (TG), high

density lipoprotein (HDL), low density lipoprotein (LDL),

fasting blood sugar level and blood pressure (P = 0.001). J Pak Med Assoc. 2010 Nov;60(11):945-8. PMID: 21375200 below

http://147.162.140.13

0/persone/masi/ricerc

a_en.html 3-8-11

Reduced Glutathione GSH

oxidized glutathione (GSSG).

GGT

" GGT within

its normal

range

may predict

various clinical

outcomes as a

marker of

internal dose

of

xenobiotics which are

conjugated with

GSH." (Arteriosclerosis,

Thrombosis, and

Vascular Biology. 2008;28:e26.) below

RESULTS.

There was a

strong dose-response relation between

serum GGT

concentrations

at baseline and

the incidence

of diabetes.

Diabetologia 2003

Mar;46(3):359-64 below

Serum

GGT

Relative

Risk of

Diabetes

< 9 1

10 to 19 8.00

20 to 29 13.30

30 to 39 12.60

40 to 49 19.60

50+ 25.80

“overconsumption of

palatable food

(chemically

altered junk

food)

triggers

addiction -like neuroadaptive responses

in brain reward circuits”

Nature Neuroscience 13, 635–

641 (2010)

doi:10.1038/nn.2519 below

60 minutes special on flavor chemists, food addiction and obesity

“CONCLUSIONS:

In this study,

adolescents

overconsumed

fast food

regardless of body

weight,” JAMA. 2004 Jun 16;291(23): 2828-

33. PMID: 15199032 below

David Kessler, MD, the former head of the

Food and Drug Administration, describes the

science of how food is made into drugs by the

creation of hyperpalatable foods the leads to

neuro-chemical addiction. drhyman.com/food-addiction below

“Sugar is a Drug.”

Candace Pert, Ph.D.

Addiction and Obesity,

Dopamine and Sugar, Lustig

© Rakowski 2008

“The supranormal stimulation of these receptors by sugar-rich diets, such as those now widely

available in modern societies, would

generate a supranormal reward signal in the brain,

with the potential to override self-control

mechanisms and thus to lead to addiction.

http://www.plosone.org/article/fetchArticle.a

ction?articleURI=info%3Adoi%2F10.1371%

2Fjournal.pone.0000698 below

94 percent of rats who were allowed to

choose mutually-exclusively between

sugar water and cocaine, chose sugar. Even rats who were addicted to cocaine

quickly switched their preference to sugar,

*

“Processed

sugar is more

addictive than

cocaine.” No wonder I have

always failed!

“Human Beings DO NOT need

carbohydrate… just ask an Eskimo…”

“Steven R. Gundry, M.D.,

Internationally renowned cardiac

surgeon, is the Medical Director of The

International Heart and Lung Institute

Center for Restorative Medicine in

Palm Springs California.” http://www.thedrpatshow.com/guests.php?guest=1060

Ketogenic Diet Audio

“the ketogenic diet can

provide symptomatic

and disease-modifying

activity in a broad range

of neurodegenerative

disorders including

Alzheimer’s disease

and Parkinson’s

disease, and may also

be protective in

traumatic brain injury

and stroke.” Behav Pharmacol. 2006 September;

17(5-6): 431–439. PMCID: PMC2367001

below PMID: 16940764

“tumour tissues metabolize approximately tenfold more

glucose to lactate in a given time than normal tissues” Nat Rev Cancer. 2011 May;11(5):325-37. Epub 2011 Apr 14. PMID: 21508971 below

“In cancer cells, glucose starvation

activates a metabolic and signaling

feedback loop leading to cell death.” http://www.nature.com/msb/journal/v8/n1/full/msb201220.html

http://www.sciencedaily.com/releases/2012/06/120626131854.htm below

“restricting an animal’s calorie intake is the most

famous intervention known to extend life span.

Discovered more than 70 years ago, it is still the

only one absolutely proven to work.” Sinclair, D.A., Guarente, L. SCIENTIFIC AMERICAN MARCH 2006 pp. 48-57 below

Everyone has heard the phrase little old lady and little old man…

how come you never hear of big old lady or big old man?

“In individuals with type II diabetes, a

single bout of exercise can reduce blood

glucose concentrations. (83)” http://physiologyonline.physiology.org/content/20/4/260.full Physiology,

Vol. 20, No. 4, 260-270, August 2005 abstract below

CAN EXERCISE HELP DIABETES?

© Rakowski 2008

“movement of

GLUT4 to

surface

membranes and the

subsequent

increase in

transport by

muscle

contractions”

Physiology (Bethesda). 2005

Aug;20:260-70. PMID:

16024514 article below

© Rakowski 2008

FIGURE 1.

Skeletal

muscle

glucose

uptake

increases

substantially

during

dynamic

exercise. The increase is

dependent mainly

on exercise

intensity but also

on exercise

duration. Adapted

from Wahren et al.

(131).

Physiology (Bethesda). 2005 Aug;20:260-70.

PMID: 16024514 article below

Normal muscle

11 receptors Exercised

conditioned

20 receptors

“The increased GLUT4 expression in muscle

following exercise training is likely due to the fact

that many genes involved in carbohydrate

metabolism (hexokinase, GLUT-4) appear to be

jointly upregulated with mitochondrial enzymes in

response to increased contractile activity (101).” http://www.endotext.org/diabetes/diabetes14/diabetesframe14.htm below

“Insulin

Resistance

IS INFLAMMATION”

Jay Lombard, D.O.

Great Lakes Conference,

Minneapolis, MN 9-25-9

Annu. Rev. Physiol. 2010.

72:219–46 abstract below

Insulin Resistance and Inflammation

“Moderate hyperinsulinemia (in normal adults) can elevate inflammatory

markers (IL‐1α, IL‐1ß, IL‐6, TNF‐α, F2‐isoprostane) and Aß42 in the

periphery and the brain, thereby potentially increasing the risk of AD.”

Fishel et al. Arch Neurol. 2005 Oct; 62(10):1539‐44.

© Rakowski 2008

25. Alzheimer’s may be considered

diabetes of the brain – video link

Brains of

Alzheimer’s

patients are

insulin

resistant

Proteins

block

insulin

receptors

Exercise

and staying

lean may

prevent

Alzheimer’s

“Aβ (amyloid beta) has been found in

mitochondria in postmortem AD brain” Proc Natl Acad Sci U S A. 2008 September 2; 105(35): 13145–13150. doi: 10.1073/pnas.0806192105. PMCID: PMC2527349

“In normal brains,

brain cells process

insulin, allowing

memories to form.

“Alzheimer's

patients have

insulin

resistance in

the brain.” http://www.sciencentral.com/articles/vie

w.php3?article_id=218393025 below,

FASEB J. 2007 Aug 24; PMID:

17720802 below

Toxic ADDLs attach near insulin receptors.

Graphic: Fernanda De Felice, Northwestern

University

The environment within: how gut microbiota may

influence metabolism and body composition: Diabetologia Vol. 53 Issue 4

DYSBIOSIS

decreased satiety

increased calorie

absorption,

increased inflammation,

decreased fat burning,

leaky gut

Nature 489, 242–249 (13

September 2012) abstract below

“STOCKHOLM -- Obese patients with a constellation of symptoms

known as the metabolic syndrome improved insulin sensitivity with a

fecal transplant from healthy thin donors, researchers here reported.

After six weeks, peripheral insulin sensitivity significantly

improved in 18 patients who received feces from lean donors compared with those who received an autologous transplant”

http://www.medpagetoday.com/MeetingCoverage/EASD/22352 below

"You have to ask what

other material do you

introduce when you

perform this transplant,"

Diamant said.

“Dietary

composition and

caloric intake

appear to swiftly

regulate intestinal

microbial

composition and

function.” J Clin Invest.

2011;121(6):2126–

2132. abstract below

“Cattle eating grasses have a

healthy gastrointestinal tract

that is not conducive to the

growth of this particular mutant

germ…It is this abnormal

environment within

cows that

consume

abnormal (corn)

diets that gave us

E. coli 0157H7.” David Katz, M.D. Director, Yale

Prevention Research

Centerhttp://www.huffingtonpost.com/d

avid-katz-md/e-coli-vegetables-blame-

meat_b_872055.html?ncid=wsc-

huffpost-cards-headline

© Rakowski 2006

“When cows

were switched

from a grain diet to hay for

only five days, O157

declined 1,000-fold.”

http://www.nytimes.com/2006/09/21/opinion

/21planck.html?ex=1160280000&en=13d8f

62aff23d082&ei=5070 Below

Noxious stimulation increases glutamate Pain. 2000 Aug;87(2):131-5. PMID: 10924806 below

“In human islets, glutamate-induced β-

cell cytotoxicity is associated to

increased oxidative stress and leads to

apoptosis and autophagy.” J Biol Chem. 2011 Feb 18. PMID: 21335552 below

“Long-lasting remission (cure?) of type 1 diabetes

following treatment with topiramate (topamax GABA

facilitator) for generalized seizures.” Acta Diabetol. 2011 Feb 19. PMID: 21336872 below

http://www.checkdiabetes.org/2010/06/diabetes-type-1-cure.html 3-9-11

*

“relationship between cell injury and autoimmune disease. A

number of mechanisms were recognized by which injury to

cells induced by infectious, chemical or physical agents can

initiate the autoimmune process.”

J Autoimmun. 2008 Feb-Mar;30(1-2):5-11. PMID: 18194728 article below

© Rakowski

2008

“The development of

new technologies for

detecting

autoantibodies have

been able to identify a

hundred of

autoantibodies and

their target

autoantigens.”

“Most autoantibodies

…innocent from

direct pathogenic

effects. Rinsho Shinkeigaku. 2007

Nov;47(11):855-7. PMID:

18210817 below

Conclusions: Patients with

insulin-dependent diabetes

melitus have immunity to

cow’s milk albumin, with

antibodies to an albumin

peptide that are capable of

reacting with beta-cell-

specific surface protein.

Such antibodies could

participate in the

development of islet

dysfunction.

Jukka Karjalainen, M.D. et al., A Bovine Albumin

Peptide as a Possible Trigger of Insulin-Dependent

Diabetes Mellitus, NEJM 1992;327;302-307

1. BI (bovine insulin) was

detectable by

radioimmunoassay (RIA) and

immunoblotting in the (cow

milk) CM-based formula.

2. “Exposure to BI, which

differs from HI only by three

amino acids, may break the

tolerance to insulin.”

3. “Antibodies to BI (Bovine

Insulin) and HI (Human Insulin)

showed a positive correlation

and cross-reacted in

inhibition studies.”

Scandinavian Journal of

Immunology. 47(2):131-135,

February 1998. below

Summary: Cow’s milk

contains cow’s insulin.

Cow Insulin looks a lot

like human insulin. This may trigger an attack

on human insulin.

“T1D has

been

associated

with viral

infections including enteroviruses, rubella,

mumps, rotavirus, parvovirus and

cytomegalovirus (CMV).”

Diabetes / Metabolism Reviews

Volume 23 Issue 3, Pages 169 – 183

abstract below

“In human islets, glutamate-induced β-

cell cytotoxicity is associated to

increased oxidative stress and leads to

apoptosis and autophagy.” J Biol Chem. 2011 Feb 18. PMID: 21335552 below

“restoration of

beta-cell function

and mass depend

on the length of

treatment period

and overall level of

glycemic control

with better control

being associated

with improved

recovery” PLoS One. 2010 Jan

18;5(1):e8749. PMID:

20090914 below

Not Cow

Not Gluten yxhealth.com

3-7-11

Stable blood sugar is the key to body composition http://www.energyfirst.com/site/files/Health-Benefits.htm below

“The more carbohydrates consumed => the more insulin in the

blood moving glucose into the cells => the more glycerol 3-phosphate is

available => the more fat is stored.”

http://www.healthy-eating-politics.com/research-on-obesity.html below

“Figure 2. A schematic diagram depicting different possible

resources and mechanisms for beta-cells regeneration.”

Frontiers in Bioscience 15, 461-477, January 1, 2010 abstract below

Beta

alpha

Figure 1. A

schematic

overview of

the cell lineage

determination

during

pancreas

development Frontiers in

Bioscience 15, 461-

477, January 1, 2010

abstract below

KEY CONCEPT

Stem cell to beta

cell is a

complicated

process.

(at 12 weeks) 43% of PED

(medical food) subjects vs.

only 22% of MED

(mediterranean diet)

subjects had net resolution

of metabolic syndrome.

Abstract below

Journal of Clinical Lipidology Volume 4, Issue 1, Pages 59-

68, January 2010 abstract below

Success is a numbers game

Wishing you

Health,

Happiness, &

Prosperity

Always!

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Dr. Bob Rakowski

thedrbob.com