The VIP Cancer MR Session · Electronic Poster The VIP Cancer MR Session Exhibition Hall Monday,...

Electronic Poster

The VIP Cancer MR SessionExhibition Hall Monday, May 9, 2016: 10:45 - 11:45

2635Computer #1

Longitudinal Diတ�usion MRI for Treatment Response Assessment: Preliminary Experience using an MRI-Guided tri-Cobalt 60Radiotherapy SystemYingli Yang , Minsong Cao , Ke Sheng , Yu Gao , Allen M Chen , Mitchell Kamrava , Percy Lee , Nzhde Agazaryan , James Lamb , David HThomas , Daniel A Low , and Peng Hu

Radiation Oncology, University of California, Los Angeles, Los Angeles, CA, United States, Radiological Sciences, University of California, LosAngeles, Los Angeles, CA, United States

Diတ�usion weighted MRI is promising for early prediction of response to radiotherapy 1, 2, and for adaptive radiotherapy, wherein thetreatment plan is adapted during treatment based on patients’ response assessed by imaging. Currently DWI-based adaptiveradiotherapy is not widely adopted because of scientiတတc and practical challenges. Most importantly, the timing for DWI imaging is notwell studied without longitudinal diတ�usion MRI data at a တတner time interval (every 2-5 days) throughout the course of treatment. Arecently commercialized MRI-guided radiotherapy system (ViewRay) may eliminate the current challenges and bring diတ�usion MRI-guided adaptive radiation therapy closer to clinical utility.

2636Computer #2

MR T1ρ imaging study on normal-appearing brain in patients with nasopharyngeal carcinoma after radiotherapyXiang Xiao , Yikai Xu , Yuankui Wu , Yingjie Mei , and Queenie Chan

Department of Medical Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou, China, People's Republic of, PhilipsHealthcare, Guangzhou, China, People's Republic of, Philips Healthcare, HongKong, China, People's Republic of

Radiation induced encephalopathy is one of the most serious complications of radiotherapy (RT) for treatment of nasopharyngealcarcinoma (NPC). In order to detect early radiation-induced changes in gray matter (GM) and white matter (WM) of NPC patients afterRT, we recruited NPC patients before RT and after RT with normal-appearing brain for MR T1ρ examination. We found abnormalmicrostructure changes of WM had already happened in NPC patients after RT even when routine MRI တတndings are negative. MR T1ρimaging can be used to detect early radiation-induced changes of WM following RT for NPC patients.

2637Computer #3

Targeted MRI contrast guided drug delivery: Magnevist and doxorubicin encapsulated into liposomes for detection and treatment ofgliomaXiaoli Liu , A. B. Madhankumar , Patti A. Miller , Becky Webb , James R. Connor , and Qing X. Yang

Radiology, College of Medicine Penn State University, Hershey, PA, United States, Neurosurgery, College of Medicine Penn State University,Hershey, PA, United States

Glioma in its early stage is hard to detect and treat because MRI contrast agent and chemotoxin are not able to cross the blood brainbarrier (BBB). The conventional MRI contrast agent such as Magnevist (GD-DTPA) is limited to the cases where the BBB is signiတတcantlycompromised by the tumor. Present study reports the development of a novel theranostic tool, interleukin-13-liposomes-Magnevist-doxorubicine (IL-13-lip-magnevist-dox) for detection and treatment of glioma. Our results demonstrated that IL-13-lip-magnevist-doxown the potential to speciတတcally target, concomitantly detect and treat glioma in its early stage when BBB is still intact.

2638Computer #4

Early Prediction and Evaluation of Breast Cancer Response to Neoadjuvant Chemotherapy Using Quantitative DCE-MRIAlina Tudorica , Karen Y Oh , Stephen Y-C Chui , Nicole Roy , Megan L Troxell , Arpana Naik , Kathleen Kemmer , Yiyi Chen , Megan LHoltorf , Aneela Afzal , Charles S Springer, Jr , Xin Li , and Wei Huang

Oregon Health & Science University, Portland, OR, United States

DCE-MRI was performed in 28 breast cancer patients (29 tumors) before, during, and after neoadjuvant chemotherapy (NACT). SeveralDCE-MRI pharmacokinetic (PK) parameters were found to be good early predictors of pathologic complete response (pCR) vs. non-pCRafter only one NACT cycle. In addition, several PK parameters and tumor size were signiတတcantly correlated with pathologically measuredresidual cancer burden (RCB).

2639Computer #5

The USPIO GEH121333 as a dual R1 and R2 Contrast Agent for Imaging Response to Anti-angiogenic TherapyJana Cebulla , Eugene Kim , Dan E Meyer , Karina Langseth , Tone F Bathen , Siver A Moestue , and Else Marie Huuse

Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway, Diagnostics, Imagingand Biomedical Technologies, Niskayuna, NY, United States, GE Healthcare AS, Oslo, Norway, Department of Medical Imaging, St. OlavsUniversity Hospital, Trondheim, Norway

Preclinical-phase iron oxide particles (GEH121333), with a high r /r ratio compared to other iron oxide nanoparticles, were used formonitoring vascular response to bevacizumab treatment in ovarian cancer xenografts. Susceptibility contrast MRI using T and T *mapping revealed a treatment induced decrease in blood volume and vessel density, but not in vessel size. Additionally, DCE-MRI usinggadodiamide detected a decrease in perfusion and/or permeability. In combination, these two methods provide a comprehensiveassessment of anti-angiogenic treatment eတ�ects.

1 1 1 2 1 1 1 1 1

1 1 2

1 2

1 1 1 2 3

1 2

3

1 2 1 2 2 1

1 2

1 1 1 1 1 1 1 1

1 1 1 1 1

1

1 1 2 3 1 1 1,4

1 2

3 4

1 2

2 2

Lastly, GEH121333 particles induced a strong signal increase in T w images, which shows promise for its use also as a positive contrastagent.

2640Computer #6

Assessment of anti-angiogenic e†‐cacy of targeted ECO/siHIF-1α nanoparticles with DCE-MRI and a biodegradable macromolecularcontrast agentAnthony Malamas and Zheng-Rong Lu

Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States

To apply DCE-MRI with a biodegradable macromolecular contrast agent in assessment of the e†‐cacy of targeted ECO/siRNAnanoparticles for silencing HIF-1α expression for cancer therapy in a mouse colon cancer model. DCE-MRI non-invasively revealed thatthe treatment resulted in over 70% reduction in average tumor blood တတow (Fp), permeability-surface area product (PS), and plasmavolume fraction (Vp) in the treatment group as compared to the saline control group (p < 0.05). The treatment was eတ�ective to inhibittumor angiogenesis and proliferation.

2641Computer #7

Inhibiting 2-hydroxyglutarate production reverses some, but not all, of the MRS-detectable metabolic markers of mutant IDH1 in gliomaPavithra Viswanath , Russell Pieper , and Sabrina M Ronen

Radiology, University of California San Francisco, San Francisco, CA, United States, Neurological Surgery, University of California San Francisco,San Francisco, CA, United States

Mutations in IDH1 are predominant in low-grade gliomas, and inhibitors of the mutant IDH1 enzyme are under investigation astherapeutic agents. Beyond 2-HG production, the IDH1 mutation also induces a broader pattern of H-MRS-detectable metabolicalterations. In this study, we investigated whether inhibiting mutant IDH1 using AGI-5198 reverses the metabolic reprogrammingobserved in IDH1 mutant glioma cells. Our results indicate that AGI-5198 treatment, while completely inhibiting 2-HG production,nevertheless only partially reverses other metabolic alterations and results in a moderate eတ�ect on clonogenicity of IDH1 mutant cells.

2642Computer #8

Assessment of R1 Relaxation Rate Error in DCE-MRI Using Bookend MeasurementsMichael Josef Dubec and Lucy Elizabeth Kershaw

CMPE, The Christie NHS Foundation Trust, Manchester, United Kingdom, Institute of Cancer Sciences, University Of Manchester, Manchester,United Kingdom

Dynamic contrast enhanced MRI (DCE-MRI) allows quantitative assessment of tumour status. The addition of a relaxation rate (R )measurement following the dynamic acquisition in DCE-MRI studies allows the uncertainty in the conversion from signal intensity (S) toR to be assessed. In this work the eတ�ect of errors in တတip angle and pre-contrast signal estimation on the S(t) to R (t) conversion wereevaluated. Results indicated that uncertainty in the measurement of S had greater eတ�ect than realistic တတip angle variations on the S(t)to R (t) conversion, and that the error was tissue dependent.

2643Computer #9

Spatial Overlapping between the Subvolumes with Elevated CBV and with Hypercellularity in GlioblastomaHemant Parmar , Daniel Wahl , Priyanka Pramanik , Michelle Kim , Theodore S Lawrence , and Yue Cao

Radiology, University of Michigan, Ann Arbor, MI, United States, Radiation Oncology, University of Michigan, Ann Arbor, MI, United States

Standard imaging for glioblastoma relies on post-contrast T1 and T2 FLAIR MRI sequences, which do not accurately reတတect tumorbiology. Advanced MRI techniques can deတတne biologically relevant and prognostic features of glioblastoma including perfusion-basedvolumes with high cerebral blood volume (V ) and high b-value diတ�usion-based hypercellular subvolume (HCV). We deတတned V andHCV in 24 patients with glioblastoma prior to undergoing chemoradiation. Surprisingly, there was little overlap between V and HCVwithin individual patients, which suggests that these volumes represent distinct aspects of tumor biology and may be independentlyprognostic. Analysis of failure patterns and prognostic relevance is ongoing.

2644Computer #10

Ultrahigh-တတeld (9.4T and 17.6T) magnetic resonance imaging of retinoblastoma: ex vivo evaluation of microstructural anatomy anddisease extentMarcus Christiaan de Jong , Pim de Graaf , Petra Pouwels , Jan-Willem Beenakker , Jeroen Geurts , Annette C. Moll , Jonas A. Castelijns ,Paul van der Valk , and Louise van der Weerd

VU University Medical Center, Amsterdam, Netherlands, Leiden University Medical Center, Leiden, Netherlands

Staging of retinoblastoma – the most common pediatric eye cancer – is currently performed in vivo at 1.5 or 3.0 T and allows for imageswith voxel sizes

Radiology, Henan Cancer Hospital, Zhengzhou, China, People's Republic of, MR Collaboration, Siemens Healthcare, Shanghai, China, People'sRepublic of, Radiology, the a�liated Cancer Hospital of Zhengzhou University, Zhengzhou, China, People's Republic of, Radiology, JohnsHopkins University School of Medicine, Baltimore, MD, United States, MR Pre-development, Siemens Healthcare, Erlangen, Germany

Overall, 6 arterial sub-phases TWIST-VIBE showed higher detection of recurrent HCCs compared with the equivalent-to-conventionalsingle arterial phase exams by providing an optimized wide observation window for tumor vascularity evaluation. This is especiallyvaluable in improving the detection of hypervascular recurrent HCCs with diameters of less than 2cm.

2646Computer #12

Multi-parametric MRI at 3.0 Tesla for the Prediction of Treatment Response in Rectal CancerTrang Pham , Michael Barton , Dale Roach , Karen Wong , Daniel Moses , Christopher Henderson , Mark Lee , Robba Rai ,Benjamin Schmitt , and Gary Liney

Radiation Oncology, Liverpool Hospital, Sydney, Australia, Faculty of Medicine, University of New South Wales, Sydney, Australia, InghamInstitute for Applied Medical Research, Sydney, Australia, Faculty of Physics, University of Sydney, Sydney, Australia, Radiology, Prince of WalesHospital, Sydney, Australia, Anatomical Pathology, Liverpool Hospital, Sydney, Australia, Faculty of Medicine, Western Sydney University,Sydney, Australia, Siemens Healthcare Pty Ltd, Sydney, Australia, Faculty of Radiation and Medical Physics, University of Wollongong,Wollongong, Australia, University of New South Wales, Sydney, Australia

A complete protocol using quantitative diတ�usion weighted imaging (DWI) and dynamic contrast enhanced (DCE) imaging in combination,and a voxel-by-voxel histogram analysis strategy was successfully developed for multi-parametric MRI prediction of treatment responsein rectal cancer. In good responders, the week 3 histograms showed a combined shift in distribution of ADC of voxels to higher valuesand K of voxels to lower values compared to the pre-CRT. Multi-parametric histogram analysis of ADC and K appears to be apromising and feasible method of assessing tumour heterogeneity and its changes in response to CRT in rectal cancer.

2647Computer #13

The study of vascular disrupting agent A64 combined with bevacizumab in the treatment of NSCLC using Multiple b-value DWIChang-Zheng Shi , Dong Zhang , Liang-Ping LUO , and Yong Zhang

Jinan University, Guangzhou, China, People's Republic of, guangzhou, China, People's Republic of, Guangzhou, China, People's Republic of, GE Healthcare MR Research China, Beijing, Beijing, China,People's Republic of

Studies showed that vascular disrupting agents and angiogenesis inhibitors had a synergistic eတ�ect for the treatment of cancer. Few previous reports used MRI to assess the combination of anti-angiogenesis drugs in non-small cell lung cancer(NSCLC). MR multi-b value diတ�usion-weighted imaging can be used to monitor the treatment of tumor by anti-angiogenesis drugs. In our study , the nude mice xenograft model was used to evaluate the role of vascular disrupting agents combing angiogenesis inhibitor in NSCLC by multiple b-value diတ�usion weighted imaging (DWI).

2648Computer #14

Characterization of Renal Tumors: Initial Experience Integrating Biomechanical and Morphological Assessment Using 3 Tesla MagneticResonance Imaging and Elastography (MRE)Davide Prezzi , Radhouene Neji , James Stirling , Sami Jeljeli , Hema Verma , Tim O'Brien , Ben Challacombe , Ashish Chandra , VickyGoh , and Ralph Sinkus

Division of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom, MR Research Collaborations,Siemens Healthcare, Frimley, United Kingdom, Department of Radiology, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom,Urology Centre, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom, Department of Histopathology, Guy's and St Thomas'

NHS Foundation Trust, London, United Kingdom

Incidentally detected renal tumors are overtreated surgically, as up to 15% of them are benign, most frequently oncocytomas. Wehypothesize that integrating biomechanical with morphological MRI assessment can improve lesion characterization, precludingunnecessary surgery. Initial experience and pathological correlation in four resected renal oncocytomas and renal cell carcinomas (RCC)demonstrate that 30Hz MRE with shear modulus elastography parametric mapping is feasible, correlating spatially with gross pathology,with lower viscosity/elasticity (y) ratios [mean = 0.22] in malignant RCCs compared to oncocytomas [mean = 0.46], showing promise forclinical application.

2649Computer #15

Integrating dynamic contrast-enhanced magnetic resonance imaging and diတ�usion kurtosis imaging for neoadjuvant chemotherapyassessment in nasopharyngeal carcinomaDechun Zheng , Yunbin Chen , Meng Liu , Qiuyuan Yue , Xiaoxiao Zhang , Hao Lin , Xiangyi Liu , Wang Ren , Weibo Chen , and QueenieChan

Radiology, Fujian Provincial Cancer Hospital, Fuzhou, China, People's Republic of, Philips Healthcare, Shanghai, China, People's Republic of,Philips Healthcare, Hong Kong, Hong Kong

DKI is an emerging technique and shows advantage than traditional DWI. Prior DCE-MRI studies suggested it had utility in earlymonitoring radiotherapy and chemotherapy sensitivity in anti-tumor treatment. However, there are a few studies investigated whethera combination of multi-modalities functional MRI techniques could improve diagnostic e†‐cacy for prediction of anti-tumor outcome.This study enrolled 53 patients who received both DCE-MRI and DKI exams during NAC courses and suggested there were collaborationbetween DCE-MRI and DKI to early monitor NAC treatments in NPC. In addition, two NAC cycles is a better time point to non-invasiveassess NAC response using fMRI.

1 2

3 4

5

1,2,3 1,2,3 4 1,2,3 2,5 2,6,7 1 1

8 1,3,9,10

1 2 3

4 5

6 7

8 9

10

trans trans

1 2 3 4

1 2 3 4

1 2 1 1 3 4 4 5

1 1

1 2

3

4 5

1 1 1 1 1 1 1 1 2

3

1 2

3

2650Computer #16

Apparent Diတ�usion Coe†‐cient Features Predict Response to Chemoradiation Treatment of Locally Advanced Cervical CancerDaisy Q Huang , Daniel Margolis , Daniel Grossi Marconi , José Humberto Tavares Guerreiro Fregnani , Ana Karina Borges , FRLucchesi , Rodrigo Rossini , Pechin Lo , Bharath Ramakrishna , Grace Lee , and Mitchell Kamrava

Radiology, Ronald Reagon UCLA Medical Center, Los Angeles, CA, United States, Radiation Oncology, Barretos Cancer Hospital, Barretos, Brazil,Radiological Sciences, Ronald Reagon UCLA Medical Center, Los Angeles, CA, United States, Radiation Oncology, Ronald Reagon UCLA Medical

Center, Los Angeles, CA, United States

FDG-PET is optimal for evaluating and predicting treatment response in cervical cancer; however, developing countries where cervicalcancer remains prevalent are more likely to have access to MR than radiotracer. Our prospective study explores the utility of MR forpredicting treatment response. Patients with locally advanced cervical cancer underwent MR at baseline, midway throughchemoradiation and after chemoradiation. Patients demonstrated robust tumor volume reduction (>93%) and increase in ADC valuesafter treatment. The discriminatory value of the standard deviation of ADC at baseline suggests that tumor heterogeneity may bepredictive of response, supporting MR’s role in identifying more aggressive tumors.

2651Computer #17

Evaluation of the tCho and β-catenin concentration with diတ�erent molecular biomarkers in breast cancer patientsKhushbu Agarwal , Gururao Hariprasad , Komal Rani , Uma Sharma , Sandeep Mathur , Vurthaluru Seenu , Rajinder Parshad , andNaranamangalam R Jagannathan

Department of NMR and MRI Facility, All India Institute of Medical Sciences, Delhi, India, Department of Biophysics, All India Institute ofMedical Sciences, New Delhi, India, Department of Pathology, All India Institute of Medical Sciences, Delhi, India, Department of SurgicalDisciplines, All India Institute of Medical Sciences, Delhi, India

We evaluated the correlation of tCho and β-catenin concentrations were correlated with molecular biomarkers (ER, PR and Her2neu) inbreast cancer patients. The nuclear β-catenin expression was signiတတcantly higher compared to cytosolic expression. A positivecorrelation between tCho and β-catenin (cytosolic and nuclear fractions) concentrations was seen. The PR- tumors had signiတတcantlyhigher cytosolic β-catenin compared to PR+ tumors. This may be because progesterone acts as an inhibitor of Wnt pathway and thus itsabsence may lead to increased cytosolic β-catenin in PR- tumors. Results demonstrated role of tCho, β-catenin and progesterone inbreast cancer progression.

2652Computer #18

MRI/MRS–based assessment of lipid metabolism: a new tool for better detection and characterization of breast tumors?Ileana Hancu , Elizabeth Morris , Christopher Sevinsky , Fiona Ginty , and Sunitha Thakur

GE Global Research Center, Niskayuna, NY, United States, Memorial Sloan Kettering Cancer Center, New York City, NY, United States

Diတ�erential expression of lipid metabolism genes was recently reported in breast cancer patients. In this pilot study, single voxel MRSdata was used to assess the spatial and spectral lipid proတတle of normal volunteers and subjects undergoing neo-adjuvant chemotherapy.Statistically signiတတcant diတ�erences in lipid proတတles from diတ�erent voxels in single volunteers and between volunteers were found.Moreover, some lipid peak ratios provided good tumor/normal tissue separation. MRI/MRS-based proတတling of lipid metabolism mayprovide a unique tool for better breast cancer tumor detection and characterization.

2653Computer #19

Metabolic Imaging Biomarker k Discriminates Breast Tumor Therapy Time-CoursesWei Huang , Alina Tudorica , Karen Y. Oh , Stephen Y-C. Chui , Nicole Roy , Megan L. Troxell , Arpana Naik , Kathleen A. Kemmer ,Yiyi Chen , Megan L. Holtorf , Aneela Afzal , Xin Li , and Charles S. Springer, Jr.

Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States, Knight Cancer Institute, Oregon Health &Science University, Portland, OR, United States, Diagnostic Radiology, Oregon Health & Science University, Portland, OR, United States, MedicalOncology, Oregon Health & Science University, Portland, OR, United States, Pathology, Oregon Health & Science University, Portland, OR, UnitedStates, Surgical Oncology, Oregon Health & Science University, Portland, OR, United States, Public Health and Preventive Medicine, OregonHealth & Science University, Portland, OR, United States

The new DCE-MRI biomarker k measures on-going vital metabolic activity. For subjects with biopsy-proven breast IDC, it monitors thecourse of neoadjuvant therapy. While k decreases for most tumors, for a sub-set it increases during therapy.

2654Computer #20

Glioblastoma growth and invasion kinetics correlate with MRI ADC metricsPamela R Jackson , Andrea Hawkins-Daarud , Joshua Jacobs , Timothy Ung , Hani Malone , Joo Kim , Olya Stringတတeld , LaurenDeGirolamo , Emilio Benbassat , Anthony Rosenberg , Joseph Crisman , Robert Gatenby , Savannah Partridge , Peter Canoll , andKristin Swanson

Neurological Surgery, Mayo Clinic, Scottsdale, AZ, United States, Mayo Clinic, Rochester, MN, United States, Pathology, Columbia University,New York City, NY, United States, Diagnostic Imaging and Interventional Radiology, H. Lee Mo�tt Cancer Center, Tampa, FL, United States,Cancer Imaging and Metabolism, H. Lee Mo�tt Cancer Center, Tampa, FL, United States, Chicago, IL, United States, Radiology, Seattle Cancer

Care Alliance, Seattle, WA, United States

We hypothesize that tumors with diတ�erent invasiveness indices (D/ρ), as predicted by the Proliferation-Invasion (PI) mathematical model,will exhibit diတ�erences in ADC. Segmented tumor volumes were determined on T1Gd and FLAIR MRIs for six GBM patients. The ROIswere used to mask registered ADC maps and parameterize the PI model for calculating D/ρ. Lower quartile ADC values within the FLAIRand FLAIR penumbra ROIs were positively correlated with D/ρ (p=0.041 and p=0.026, respectively). ADC skewness within the T1Gd ROInegatively correlated with D/ρ (p=0.021). Understanding the relationship between D/ρ and ADC could be important for targeting brain

1 1 2 2 2

2 2 3 3 3 4

1 2

3 4

1 2 2 1 3 4 4

1

1 2

3 4

1 2 1 1 2

1 2

io1,2 3 3 2,4 3 2,5 2,6 4

2,7 2 1 1 1

1 2

3 4

5

6 7

io

io

1 1 2 3 3 4 5

1 6 6 6 4 7 3

1

1 2 3

4

5 6 7

tumor therapies.

2655Computer #21

Characterization of Myxoid Soft Tissue Tumors as Benign or Malignant Using Texture Analysis of the Apparent Diတ�usion Coe†‐cientHyun Su Kim , Jae-Hun Kim , and Young Cheol Yoon

Radiology, Samsung medical center, Seoul, Korea, Republic of

Myxoid soft tissue tumors (STTs) are histologically unique group of tumors that have been proven to have signiတတcantly higher ADCvalues than nonmyxoid counterparts. In addition, no signiတတcant diတ�erence of mean ADC value exists between benign and malignantmyxoid STTs. We propose texture of ADC value as a new parameter for diတ�erentiating benign and malignant myxoid STTs. The global(mean, standard deviation, skewness and kurtosis), regional (intensity variability and size-zone variability), and local features (energy,entropy, correlation, contrast, homogeneity, variance and maximum probability) were extracted from ADC values of each tumor groupfor texture analysis and statistical comparisons were performed.

2656Computer #22

Intravoxel incoherent motion (IVIM) imaging for diတ�erential diagnosing hepatocellular carcinoma (HCC), hepatic hemangioma andhepatic metastasis.Ye Ju , Ai-lian Liu , Qing-wei Song , Mei-yu Sun , Jing-hong LIU , Li-hua Chen , Zheng Han , Yi-min WANG , and Li-zhi Xie

The First A�liated Hospital of Dalian Medical University, Dalian, China, People's Republic of, GE Healthcare, MR Research China, Beijing,Beijing, China, People's Republic of

The diတ�usion property of tumor tissues largely depends on cell density, which may also be predictive features of malignancy in sometypes of tumors. Intravoxel incoherent motion (IVIM) imaging is an extension of diတ�usion weighted imaging (DWI) that can be used toinvestigate both diတ�usion and perfusion changes in tissues. Comparing the IVIM parameters between carcinoma (HCC), hepatichemangioma and hepatic metastasis, we found that IVIM can facilitates understanding of tumor tissue characteristics of perfusion anddiတ�usion, and it may provide more useful information to distinguish hemangiomas from other two malignant tumors.

2657Computer #23

Pairwise metabolite-metabolite correlation analysis (MMCA) of HR-MAS 1H NMR spectra from 407 human brain tumoursBasetti Madhu , Sean McGuire , Alexandra Jauhiainen , and John R Gri†‐ths

Molecular Imaging (MRI & MRS), Cancer Research UK Cambridge Institute, Cambridge, United Kingdom, Early Clinical Biometrics, AstraZenecaAB R&D, Molndal, Sweden

Human brain tumour tissues from glioblastoma multiforme, astrocytoma, meningioma, oligodendroglioma and metastatic tumourswere analyzed by metabolite-metabolite correlation analysis of HRMAS 1H NMR spectra from the eTumour database. The followingmetabolites were quantiတတed using a modiတတed LC-Model basis set: alanine (Ala), choline (Cho), creatine (Cr), lactate (Lac), glutamine (Gln),glutamate (Glu), glycine (Glyn), N-acetylaspartate (NAA), phosphocholine (PCh), phosphocreatine (PCr), taurine (tau), myo-inositol (Ino)and various lipids/macromolecules. The estimated metabolite concentrations from LCModel တတttings were used in the investigation ofpairwise metabolite-metabolite correlations. Pairwise metabolite-metabolite correlations can serve as an overview of metabolism andcan be helpful in understanding the cellular metabolism.

2658Computer #24

Imbalanced learning techniques for improved classiတတcation of paediatric brain tumours from magnetic resonance spectroscopyNiloufar Zarinabad , Christopher Bennett , Simrandip Gill , Martin P Wilson , Nigel P Davies , and Andrew Peet

Institute of Cancer and Geonomic Sciences, University of Birmingham, Birmingham, United Kingdom, Birmingham Children’s Hospital NHSfoundation trust, Birmingham, United Kingdom, Department of Medical Physics,University Hospitals Birmingham NHS Foundation Trust,Birmingham, United Kingdom

Classiတတcation of paediatric brain tumours from Magnetic-Resonance-Spectroscopy has many desirable characteristics. However theimbalanced nature of the data introduces di†‐culties in uncovering regularities within the small rare tumour type group and attempts totrain learning algorithms without correcting the skewed distribution may be premature. By fusing oversampling and classiတတcationtechniques together, an improved classiတတcation performance across diတ�erent classes with a good discrimination for minority class canbe achieved. The choice of learning algorithm, use of oversampling-technique and classiတတer input (complete spectra versus metabolite-concentration) depends on the data distribution, required accuracy in discriminating speciတတc groups and degree of post-processingcomplexity.

Electronic Poster

Educational E-PosterExhibition Hall Monday, May 9, 2016: 10:45 - 11:45

2659Computer #25

In vitro Imaging of Alanine: Application of CEST MRIPuneet Bagga , Srisha Bolledula , Harsith Reddy , Rishika Reddy , Apoorva Sudini , Hari Hariharan , and Ravinder Reddy

Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States

1 1 1

1

1 1 1 1 1 1 1 1 2

1 2

1 1 2 1

1 2

1,2 1,2 1,2 1 1,2,3 1,2

1 2

3

1 1 1 1 1 1 1

1

Alanine is a highly abundant non-essential amino acid which provides an alternate source of TCA cycle intermediates for energy and cellsurvival. It has been shown that myc-driven tumors utilize alanine as an energy source over lactate. Currently, alanine can be detected invivo only by C NMR spectroscopy. Chemical Exchange Saturation Transfer (CEST) MRI is an imaging technique which exploits theproperties of exchangeable protons on the molecule for imaging. In the present study, we have shown the in vitro CEST eတ�ect ofsolution containing alanine.

2660Computer #26

UTILITY OF PET-MRI IN INITIAL STAGING, TREATMENT PLANNING AND FOLLOW UP OF GYNECOLOGIC CANCERSRAJ MOHAN PASPULATI , KARIN HERMAN , and AMIT GUPTA

RADIOLOGY, UNIVERSITY HOSPITALS, CASE WESTERN RESERVE UNIVERSITY, CLEVELAND, OH, United States

In this exhibit we share our 3 year experience of sequential design PET-MR (Phillips Ingenuity TF PET/MR) application in staging andfollow up of gynecologic cancers. Hybrid PET-MR imaging is a new evolving technique and has a useful role in staging, treatmentplanning and follow up of gynecologic cancers. Standardization of the imaging protocol and understanding its limitations and pit falls isessential before considering regular clinical application.

2661Computer #27

Automated Segmentation of Ewing’s Sarcoma using Diတ�usion Weighted ImagingAmit Mehndiratta , Abhimanyu Sahai , Esha Baidya Kayal , Jayendra Tiru Alampally , Sameer Bakhshi , Devasenathipathy K , and RajuSharma

Center for Biomedical Engineering, Indian Institute of Technology Delhi, New Delhi, India, Department of Biomedical Engineering, All IndianInstitute of Medical Sciences, New Delhi, India, Department of Radiology, All India Institute of Medical Sciences, New Delhi, India, BRA IRCH, AllIndia Institute of Medical Sciences, New Delhi, India

Accurate demarcation of tumors on DWI MRimages could play a crucial role in diagnosis and prognosis when using quantitative imageanalysis like ADC or IVIM. Manual demarcation of tumour on each slice of a 3D stack is usually not feasible. Automated or semi-automated methods of segmentation are thus desirable speciတတcally for DWimages that can be used to identify the tumor region,optimizing on both speed and accuracy. Our results reveals that semi-automated algorithms based on both Otsu-threshold or Active-Contours based region growing perform tumour segmentation with acceptable level of accuracy in diတ�usion MRimages and reduce timeand manual eတ�ort required.

2662Computer #28

How to make a diagnosis and diတ�erential diagnoses for superတတcial soft-tissue solid masses by magnetic resonance imaging: ourexperiences and initial resultsJingfeng Zhang , lingxiang Ruan , Qidong Wang , and Bingying Lin

Dept. of Radiology, 1st A�liated Hospital, School of Medicine, Zhejiang University, Hangzhou, China, People's Republic of, Hangzhou, China,People's Republic of

Superတတcial soft-tissue masses are common in clinical practice, and most of them are solid. The radiological imaging is available toprovide more detailed information, which is more helpful to make a diagnosis and diတ�erential diagnosis. Additionally, analysis ofimaging features is useful in distinguishing between benign and malignant lesions, which can help make a strategy for therapy , such aspreoperative planning of the extent of surgery and whether adjuvant chemotherapy/radiotherapy. Lesions that are assigned benign canbe followed expectantly, whereas indeterminate or malignant lesions can be subjected to histological evaluation.The location of a solidmass within the superတတcial tissue is best described as cutaneous (epidermis and dermis); subcutaneous (adipose tissue, nerve tissue,တတbrous tissue and vascular tissue etc.); or fascial (overlying the muscle). Cutaneous lesions may arise in association with the epidermisor dermis, and subcutaneous lesions may arise in the adipose tissue, or the fascia overlying the muscle. However, some lesions caninvade the cutaneous and subcutaneous tissue simultaneously. For purposes of comprehensive understanding and analysis, it is mostuseful to categorize superတတcial soft-tissue solid masses by histology as skin appendage tumors, mesenchymal tumors and metastatictumors.

2663Computer #29

Physics in Motion: Diတ�usion Weighted Imaging - An Illustrated ReviewYi Xiong Ong , Fang Yang Sim , and Le Roy Chong

Changi General Hospital, Singapore, Singapore

An educational video which uses simple animations to describe the random thermal molecular motion that is diတ�usion, and how thediတ�usion process can be demonstrated with the magnetic resonance signal.

Electronic Poster

Atherosclerosis ImagingExhibition Hall Monday, May 9, 2016: 10:45 - 11:45

2664 The Ability to Detect Intracranial Arterial Calciတတcations: Evaluation of 3D TOF MRA and SNAP

13

1 1 1

1

1,2 1 1 3 4 3

3

1 2

3 4

1 2 2 2

1 2

1 1 1

1

1 1 1 1 1 1 1

Computer #31 Mahmud Mossa-Basha , Haining Liu , Dan S. Hippe , Niranjan Balu , Jie Sun , Dean Shibata , and Chun Yuan

Radiology, University of Washington Medical Center, Seattle, WA, United States

Intracranial arterial calciတတcation evaluation has shown increasing importance in the literature based on associations with current andfuture stroke events, dementia and cognitive decline. We hypothesize that the proton-density image, SNAP Ref, that is generated withSimultaneous Non-contrast Angiography and intraPlaque hemorrhage (SNAP) can more adequately assess calciတတcations compared to3D TOF MRA relative to the reference standard, thin slice CTA.

2665Computer #32

Simultaneous multi-slice carotid vessel wall MRI with DIR-FSESagar Mandava , Mahesh Bharath Keerthivasan , Kevin Johnson , Diego R. Martin , Ali Bilgin , and Maria I. Altbach

Electrical and Computer Engineering, University of Arizona, Tucson, AZ, United States, Siemens Healthcare, Tucson, AZ, United States, MedicalImaging, University of Arizona, Tucson, AZ, United States, Biomedical Engineering, University of Arizona, Tucson, AZ, United States

The DIR-FSE sequence is popularly used to assess plaque build up but is known to be a single slice technique due to a non-selectiveinversion pulse used in the DIR module. In this work we present a technique to improve the SNR e†‐ciency of DIR-FSE sequences bymulti-band excitation. The proposed technique can generate multiple slices at the exact null point of blood and the acquired data can beused to create upto 16 TE images and T2 maps for all the acquired slices.

2666Computer #33

Post-Contrast T1w Black Blood Images of Atherosclerotic Plaque using 3D DANTE prepared Stack of Stars (3D DANTE-SOS) Sequence andciné Reconstruction Method using Retrospective Ordering and Compressed Sensing (ciné-ROCS)Seong-Eun Kim , John A Roberts , J Scott McNally , Bradley D Bolster, Jr. , Gerald S Treimam , and Dennis L Parker

Department of Radiology, UCAIR, University of Utah, Salt Lake City, UT, United States, Siemens Healthcare, Salt Lake City, UT, United States,Department of Surgery, University of Utah, Salt Lake City, UT, United States, Department of Veterans A�airs, VASLCHCS, Salt Lake City, UT,

United States

Contrast enhanced T1 imaging has been used to aid in the detection of the တတbrous cap overlying the necrotic core. We haveimplemented 3D SOS with retrospective cardiac cycle gated compressed sensing reconstruction to minimize, characterize artifacts inpost-contrast imaging. Radial based k-space trajectory may oတ�er reduced motion sensitivity and more robust ciné-ROCS reconstructionsdue to its inherent oversampling of central k-space. Ciné-ROCS reconstruction from 3D SOS acquisition demonstrates improveddemonstration of တတne plaque structures and vessel wall movement due to cardiac motion to the regular reconstruction and may helpprovide information on symptomatic plaque development and response to treatment.

2667Computer #34

Motion insensitive high resolution in vivo DWI of Carotid Artery Wall Imaging using 3D Diတ�usion Weighted Driven Equilibrium Stack ofStars (3D DW-DE SOS) sequenceSeong-Eun Kim , J Scott McNally , Bradley D Bolster, Jr. , Gerald S Treimam , and Dennis L Parker


United States

DWI might provide a tool for discriminating intraplaque hemorrhage and lipid core from other components. Motion insensitive 3D DW-DE SOS has been developed to acquire high resolution DWI to improve the accuracy of ADC measurements. This technique was able toyield high resolution ADC that could provide clear ROI selection for important plaque components. Increased spatial resolution inmotion insensitive 3D DW-DE SOS can improve the sensitivity of ADC maps in plaque component identiတတcation. The results obtainedindicate that an ADC map may be of substantial value in identifying lipid and hemorrhage within overall plaque burden.

2668Computer #35

Motion Insensitive 3D technique for simultaneous measurement of in-vivo ADC and T2* in Atherosclerotic plaque using a 3D MultipleEcho Diတ�usion Weighted Driven Equilibrium Stack of Stars (3D ME-DW-DE SOS) Sequence.Seong-Eun Kim , J Scott McNally , Bradley D Bolster, Jr. , Gerald S Treimam , and Dennis L Parker


United States

DWI has the potential to provide complementary information that will allow better discrimination of plaque components such as lipidcore. Iron has consistently been found in higher concentrations in atherosclerotic plaque compared to vessel tissue. In previous studies,intraplaque T2* distinguished symptomatic from asymptomatic plaques in patients with carotid atherosclerosis. In this work weintroduce simultaneous measurement of ADC and T2* using a motion insensitive high resolution 3D multiple echo diတ�usion weighteddriven equilibrium Stack of Stars sequence. This technique can provide high resolution T2* and ADC values simultaneously, which mayprovide important clinical information to detect plaque progression.

2669Computer #36

Characterization of carotid plaque using sampling perfection with application-optimized contrast using diတ�erent တတip angle evolution(SPACE) sequenceYoshimitsu Ohgiya , Nobuyuki Ohike , Naomi Yagi , Hiroto Sasamori , Jiro Munechika , Masanori Hirose , and Takehiko Gokan

1 1 1 1 1 1 1

1

1 1 2 3 1,3,4 3

1 2 3

4

1 1 1 2 3,4 1

1 2

3 4

1 1 2 3,4 1

1 2

3 4

1 1 2 3,4 1

1 2

3 4

1 2 1 1 1 1 1

1 2

Showa University School of Medicine, Tokyo, Japan, Department of Pathology, Showa University Fujigaoka Hospital, Yokohama-shi, Japan

The purpose of this study was to investigate whether 3D turbo spin-echo (TSE) SPACE sequence can evaluate plaque characteristics ofthe carotid artery. Mann-Whitney test was used to examine diတ�erences in the contrast ratio (CR) between soft plaques and တတbrousplaques on T1- and T2-weighted images. The mean CR of the soft plaques (1.54 ± 0.25) was signiတတcantly higher than that of the တတbrousplaques (1.17 ± 0.13) (p < 0.001) on T1-weighted images. In conclusion, T1-weighted TSE SPACE sequence can evaluate main componentsof plaques in the carotid artery with high sensitivity and speciတတcity.

2670Computer #37

Selective reacquisition for motion artifact reduction in quantitative T2 mapping of carotid artery vessel wallRobert Frost , Aaron T. Hess , Linqing Li , Matthew D. Robson , Luca Biasiolli , and Peter Jezzard

FMRIB Centre, Nu�eld Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, Oxford Centre for ClinicalMagnetic Resonance Research, Division of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom, Section on MagneticResonance Spectroscopy, National Institute of Mental Health, Bethesda, MD, United States

Ghosting and blurring artifacts caused by swallowing or coughing can be a signiတတcant problem in quantitative T2 mapping ofatherosclerotic plaque in the carotid artery. The method is based on a multi-slice multiple spin-echo sequence which acquires k-spacelines sequentially with a 2 s gap between lines. A navigator echo was added at the end of the echo-train to identify and reacquire datacorrupted by motion. The selective reacquisition reduced ghosting and blurring artifacts in healthy volunteer scans with intentionalswallowing motion.

2671Computer #38

Feasibility of Vessel Wall Imaging of the Superတတcial Palmar Arch using 7T and 3T MRIAlison N. Pruzan , Audrey Kaufman , Claudia Calcagno , Yu Zhou , Zahi A. Fayad , and Venkatesh Mani

Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, Translational and Molecular Imaging Institute,Icahn School of Medicine at Mount Sinai, New York, NY, United States

Evaluation of atherosclerosis in smaller arteries in the hand may be clinically useful in certain disease conditions such as Diabetes. Wesought to demonstrate feasibility of vessel wall imaging of the superတတcial palmar arch using 7T and 3T MRI in comparison with very highfrequency micro ultrasound. Results indicated that 7T imaging of the palmar arch was feasible and subjective image quality analysis wasbetter than 3T and ultrasound.

Electronic Poster

MRAExhibition Hall Monday, May 9, 2016: 10:45 - 11:45

2672 Computer #49

Four-Dimensional, Multiphase, Steady-State Imaging with Contrast Enhancement (MUSIC) with Improved Functional AssessmentZiwu Zhou , Fei Han , Takegawa Yoshida , Kim-Lien Nguyen , Paul Finn , and Peng Hu

Radiological Sciences, University of California, Los Angeles, Los Angeles, CA, United States

A recent proposed technique called four dimensional, multiphase, steady-state imaging with contrast enhancement (MUSIC) enablesdetailed anatomical assessment of cardiovascular system. However, limited available cardiac phase prevents accurate functionalassessment of the heart. In this study, we compared original MUSIC with an improved MUSIC technique that generates double cardiacphases. Initial results suggest a more accurate left ventricular volume measurement and better appreciation of cardiac wall motion canbe achieved with more cardiac phases.

2673Computer #50

Eတ�ect of Gadolinium-Induced Susceptibility on First-Pass Single-echo Dixon CE-MRA and Methods for CorrectionEric G. Stinson , Joshua D. Trzasko , and Stephen J. Riederer

Radiology, Mayo Clinic, Rochester, MN, United States

Single-echo Dixon imaging for contrast-enhanced MR angiography (CE-MRA) can provide the advantages of multi-echo Dixon withoutthe tradeoတ� of longer acquisitions and reduced temporal resolution. Single-echo Dixon imaging assumes that both the water and fatsignals are real and have known initial phase and phase due to တတeld inhomogeneities. However, when a paramagnetic Gadolinium-based contrast agent is injected for CE-MRA, the တတeld may be perturbed and render the a priori phase estimates invalid. The purpose ofthis study is to demonstrate the eတ�ect of Gd-induced တတeld perturbations on တတrst-pass single-echo Dixon CE-MRA and describe strategiesto avoid or correct artifacts.

2674Computer #51

Preliminary evaluation of Respiratory Self Navigated Whole-Heart Angiography in Combination with Ultra-small Super-paramagneticIron Oxide ParticlesDavide Piccini , Peter J. Weale , Saeed Mirsadraee , Rachel O. Forsythe , Annette S. Cooper , and Scott Semple

Advanced Clinical Imaging Technology, Siemens Healthcare, Lausanne, Switzerland, Department of Radiology, University Hospital (CHUV) andUniversity of Lausanne (UNIL), Lausanne, Switzerland, Siemens Healthcare Ltd, Camberley, United Kingdom, NHS Lothian & Clinical Research

1 2

1 2 3 2 2 1

1 2

3

1,2 1,2 1,2 1,2 1,2 1,2

1 2

1 1 1 1 1 1

1

1 1 1

1

1,2 3 4 5 6 5,6

1 2

3 4

5

Imaging Centre Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom, Centre for Cardiovascular Science,University of Edinburgh, Edinburgh, United Kingdom, Clinical Research Imaging Centre, University of Edinburgh, Edinburgh, United Kingdom

Respiratory self-navigated 3D-radial MRA is an e†‐cient and robust method for the depiction of coronary luminal anatomy at 1.5T.Higher magnetic တတelds are more challenging, due to oတ�-resonance artifacts. Contrast-enhanced imaging is usually beneတတcial. However,variable contrast during prolonged scans can deteriorate the self-navigation signal. Here we investigate the use of an ultra-small super-paramagnetic iron oxide particles (USPIO) contrast agent with longer half-life in combination with self-navigation at 3T. Systolic anddiastolic datasets from 10 volunteers were acquired and analyzed. We show that USPIO contrast-enhanced self-navigated coronary MRAis feasible at 3T with good image quality and reliable motion correction.

2675Computer #52

Feasibility of Subtractionless Three-Station First-Pass Peripheral MRA at 3 THolger Eggers , Bernhard Schnackenburg , Marc Kouwenhoven , Alan Huang , Tim Leiner , Rolf Gebker , and Sebastian Kelle

Philips Research, Hamburg, Germany, Philips Healthcare, Hamburg, Germany, Philips Healthcare, Best, Netherlands, Department ofRadiology, University Medical Center Utrecht, Utrecht, Netherlands, German Heart Institute Berlin, Berlin, Germany

Chemical shift encoding-based water-fat imaging, or Dixon imaging, has recently been demonstrated to permit တတrst-pass peripheralMRA without subtraction. While previous work focused on an evaluation at 1.5 T, this work explores the feasibility of this subtractionlessmethod at 3 T. Results on the တတrst six patients are presented and are compared with the established subtraction method. Substantialimprovements in image quality are seen, and the use of three stations is, despite particular challenges at 3 T, preliminarily found to bepracticable.

2676Computer #53

International, Multicenter Phase 3 Blinded Study of the Structural Visualization, Diagnostic E†‐cacy and Safety of Gadobutrol (Gadavist)Enhanced MRA of the Renal Arteries compared to Time-of-Flight MRA using CTA as the standard of reference (SoR)Jacob Agris , Neda Rastegar , Kelly Fabrega-Foster , Sheela Agarwal , Daniel Haverstock , and Ihab Kamel

Radiology, Bayer, Whippany, NJ, United States, Radiology, Johns Hopkins, Baltimore, MD, United States, Radiology, Massachusetts GeneralHospital, Boston, MA, United States, Statistics, Bayer, Whippany, NJ, United States

International, multicenter phase 3 blinded study comparing the performance of CE-MRA with Gadobutrol, a high relaxivity and highlystable macrocyclic contrast agent, to 2D Time-of-တတight MRA (ToF) using CTA as the standard of reference (SoR). 317 patients suspected ofrenal artery disease were enrolled. There was almost no error in the Gadobutrol MRA vessel measurements (0.0mm Gadobutrol vs0.5mm ToF for stenosis measurements) and superior assessability as well as superior speciတတcity was demonstrated reducing the needfor additional imaging studies by 50%. Gadobutrol enhanced MRA of the renal arteries has superior visualization, more accuratemeasurements and is a valuable alternative to CTA without any ionizing radiation.

2677Computer #54

Lung Perfusion: MRI vs SPECT for screening in suspected Chronic Thromboembolic Pulmonary HypertensionChristopher S Johns , Smitha Rajaram , David Capener , David G Kiely , Andrew J Swift , and Jim M Wild

Academic Unit of Radiology, University of She�eld, She�eld, United Kingdom, Radiology Department, She�eld Teaching Hospitals, She�eld,United Kingdom, She�eld Pulmonary Vascular Clinic, She�eld Teaching Hospitals, She�eld, United Kingdom, Institute of Insilico Medicine, TheUniversity of She�eld, She�eld, United Kingdom

A comparison of perfusion SPECT and MRI in screening for chronic thromboembolic disease. To assess the role of MRI perfusion in theclinical imaging pathway in this patient group.

2678Computer #55

Estimation of Error in Volume Measurement for 100 Intracranial Aneurysms Imaged Serially with CE-MRA at 1.5T and 3TFarshid Faraji , Alastair Martin , and David Saloner

Department of Radiology, UCSF, San Francisco, CA, United States

Intracranial aneurysms are localized dilations in blood vessels occurring in 1-6% of the population which can have devastatingconsequences in the event of rupture. Many aneurysms are asymptomatic, found incidentally, and fall below the surgical size threshold.For this reason, physicians choose to follow aneurysms with imaging rather than opting for surgical or endo-vascular intervention. Herewe further our analysis of a previously presented image processing technique using contrast-enhanced MRA to follow intracranialaneurysms longitudinally. We investigate the measurement error of this post-processing technique in 100 intracranial aneurysms, andevaluate the diတ�erential eတ�ects of imaging at 1.5T and 3T.

2679Computer #56

Intra-individual quantitative and qualitative comparison of 4D-MRA- and dynamic CTA-bolus-time-curves of gadopentetate dimeglumineand gadobutrol in minipigsDariusch Reza Hadizadeh , Vera Catharina Keil , Gregor Jost , Hubertus Pietsch , Martin Weibrecht , Bishr Agha , Christian Marx ,Michael Perkuhn , Hans Heinz Schild , and Winfried Albert Willinek

Radiology, University of Bonn, Bonn, Germany, MR and CT Contrast Media Research, Bayer Healthcare, Berlin, Germany, InnovativeTechnologies, Research Laboratories, Philips Technologie GmbH, Aachen, Germany, Department of Radiology, Neuroradiology, Sonography andNuclear Medicine, Brüderkrankenhaus Trier, Trier, Germany

In an animal model bolus kinetics and image quality after injection of 1M gadobutrol (standard and half-dose) and 0.5M gadopentetate

5

6

1 2 3 3 4 5 5

1 2 3 4

5

1 2 2 1,3 4 2

1 2 3

4

1 2 1 3 1,4 1

1 2

3 4

1 1 1

1

1 1 2 2 3 1 1

3 1 4

1 2 3

4

dimeglumine (standard-dose) had been investigated in 4D-MRA at 3T and dynamic CTA. The တတrst pass arterial peak Gd-concentrations(quantiတတed by CTA) were higher for standard-dose compared to half-dose gadobutrol. In 4D-MRA the တတrst pass arterial peakenhancement was comparable for both gadobutrol doses and gadopentetate dimeglumine due to peak cut-oတ� eတ�ects at high vascularGd concentrations. Markedly higher venous bolus peaks were found for standard-dose gadobutrol. Image quality of 4D-MRA was ratedsigniတတcantly higher for both doses of gadobutrol.

2680Computer #57

Evaluate Relative Helicity of Aortic Flow for Marfan Syndrome by 4D Flow Phase Contrast MRIPin-Chen Chen , Hsin-Hui Chiu , Wen-Yih Isaac Tseng , and Hsu-Hsia Peng

Institute of Systems Neuroscience, Hsinchu, Taiwan, Department of Pediatrics, Taipei, Taiwan, Center for Optoelectronic Biomedicine, Taipei,Taiwan, Department of Biomedical Engineering and Environmental Sciences, Hsinchu, Taiwan

We aim to evaluate relative helicity of aortic တတow for patients with Marfan syndrome (MFS) by 4D တတow phase-contrast MRI. An individualhelicity mapping was composed to provide the information of the spatiotemporal distribution of relative helicity. The E signrepresents the relative helicity cores shown in the early diastole whereas D sign represents the relative helicity core shown time-delayedand downstream. The A sign represents an additional relative helicity core other than D, E, or the normal single cores. MFS patientsshowed abnormal relative helicity core in helicity mapping, which provided promising approaches for patient managements in thefuture.

2681 Computer #58

Evaluation of Dual Agent Relaxation Contrast MR Lymphangiography (DARC-MRL) for Pre-surgical Identiတတcation of Lymphatic ChannelsBeth Ripley , Gregory J Wilson , and Jeတ�rey H Maki

Department of Radiology, University of Washington Medical Center, Seattle, WA, United States

A new method of lymphatic channel mapping was evaluated in a retrospective review of pre-surgical lymphedema MR exams. DualAgent Relaxation Contrast MR Lymphangiography (DARC-MRL) uses intracutaneous injection of a Gd contrast agent for enhancement oflymphatic channels and concomitant intravenous injection of USPIO (ferumoxytol) for suppression of (otherwise lymphatic-obscuring)veins. 43 MR exams using DARC-MRL were compared to 43 matched exams using conventional (no USPIO) MR lymphangiography.Exams were graded for degree of venous contamination, and DARC-MRL exams exhibited dramatically less obscuring venouscontamination than the conventional method.

2682Computer #59

Cardiac and Respiratory Motion-Resolved Free-Running Whole-Heart Coronary MRA of Patients Using 5D XD-GRASP Reconstruction.Giulia Ginami , Simone Coppo , Li Feng , Davide Piccini , Tobias Rutz , Ricardo Otazo , Daniel Sodickson , Matthias Stuber , andJerome Yerly

University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, Center for Advanced Imaging Innovation and Research(CAI2R), Department of Radiology, New York University School of Medicine, New York, NY, United States, Advanced Clinical Imaging Technology,Siemens Healthcare, Lausanne, Switzerland, Division of Cardiology and Cardiac MR Center, University Hospital of Lausanne (CHUV), Lausanne,Switzerland, Center for Biomedical Imaging (CIBM), Lausanne, Switzerland

Free-running self-navigated techniques have been introduced in order to allow for time resolved three-dimensional whole-heart MRacquisitions. A more recently proposed free-running 5D (x-y-z-cardiac-respiration) XD-GRASP (eXtra-Dimensional Golden-angle RAdialSparse Parallel MRI) approach enables acquisition and reconstruction of cardiac- and respiratory-motion resolved 3D volumes. In thisstudy, we investigated the potential of 5D XD-GRASP in a clinical setting.

2683Computer #60

MRI of peripheral vascular calciတတcations using stack-of-stars 3D FLASHMarcos Paulo Botelho , Shivraman Giri , Ioannis Koktzoglou , Alto Stemmer , and Robert R. Edelman

Radiology, NorthShore University HealthSystem, Evanston, IL, United States, Siemens Healthcare, Chicago, IL, United States, Radiology,University of Chicago Pritzker School of Medicine, Chicago, IL, United States, Siemens Healthcare GmbH, Erlangen, Germany, Radiology,Feinberg School of Medicine, Northwestern Univesity, Chicago, IL, United States

We evaluated a novel approach for visualizing and quantifying peripheral arterial calciတတcations using a stack-of-stars 3D FLASH pulsesequence. The technique permitted isotropic 1mm3 spatial resolution and displayed dark calciတတcations against a relatively uniformbright background. Banding artifacts relating to chemical shift were minimized by the use of radial in-plane spatial encoding and an in-phase echo time, while vascular signal was enhanced by the use of a low တတip angle near the Ernst angle of blood. In patients withperipheral arterial disease, there was excellent correlation using CT angiography as the standard of reference.

2684Computer #61

Non-Contrast Gate-Free Aortic MR Angiography with Robust Fat SuppressionNobuyuki Toyonari , Masami Yoneyama , Seiichiro Noda , Yukari Horino , and Kazuhiro Katahira

Kumamoto Chuo Hospital, Kumamoto, Japan, Philips Electronics Japan, Tokyo, Japan

Non-contrast MR angiography (MRA) is a promising method to diagnose and follow-up of vascular diseases such as dissecting aorticaneurysm. Conventionally, 3D gated balanced steady-state free precession (bSSFP) is used for the aorta, but it has several limitations. Toovercome bSSFP’s limitations , we propose a new technique based on gradient echo DIXON sequence with တတow-independent relaxation-enhanced non-contrast MRA technique (Relaxation-Enhanced Angiography without Contrast and Triggering: REACT). We showed thatREACT could provide more robust and stable MRA without any artifacts and failed fat suppression compared with conventional bSSFP.

1 2 3 4

1 2 3

4

AED

AED

1 1 1

1

1 1 2 1,3 4 2 2 1,5

1,5

1 2

3

4

5

1 2 1,3 4 1,5

1 2 3

4 5

1 2 1 1 1

1 2

2685Computer #62

Time-of-တတight unlimited: Novel self-gated unenhanced peripheral MR angiography with continuous table movement in less than 7minutesMichael O. Zenge , Justin Ream , Ankur Doshi , Mary Bruno , Christopher Stroehlein , Peter Speier , Hersh Chandarana , and Harald H.Quick

Siemens Healthcare, Malvern, PA, United States, Radiology, NYU Langone Medical Center, New York, NY, United States, Siemens Healthcare,Erlangen, Germany, Erwin L. Hahn Institute for MR Imaging, University Duisburg-Essen, Essen, Germany, High Field and Hybrid MR Imaging,University Hospital Essen, Essen, Germany

Although unenhanced MR angiography eliminates the need for contrast injection, it would use ECG triggering which adds extra time andcomplexity to patient preparation. In the current work, time-of-တတight (TOF) unlimited introduces self-gated rapid, radial MR imaging withcontinuous table movement for seamless coverage of the peripheral vasculature. In-vivo experiments in တတve healthy volunteers and twopatients were performed. Initial results are more than promising and TOF unlimited demonstrates similar image quality compared toconventional ECG triggered TOF despite sevenfold accelerated data acquisition. Thus, novel TOF unlimited may be a time e†‐cientscreening tool for peripheral arterial disease.

2686Computer #63

Reduction of image artifacts in non-contrast-enhanced velocity-selective peripheral MRA at 3TTaehoon Shin , Qin Qin , Jang-Yeon Park , Robert S. Crawford , and Sanjay Rajagopalan

Diagnostic radioloy and nuclear medicine, University of Maryland, Baltimore, MD, United States, Radiology, Johns Hopkins University,Baltimore, MD, United States, Biomedical Engineering, Sungkyunkwan University, Suwon, Korea, Republic of, Center for neuroscience imagingresearch, Insititute for Basic Science, Suwon, Korea, Republic of, Vascular and endovascular surgery, University of Maryland, Baltimore, MD,United States, Cardiovascular Medicine, University of Maryland, Baltimore, MD, United States

Velocity-selective (VS) magnetization-prepared non-contrast-enhanced MR angiography has advantages of large 3D FOV, arbitrary 3Dspatial resolution and need for single acquisition only. Peripheral VS-MRA has shown great potential at 1.5T but might be challenging at3T due to large B0 and B1 inhomogeneity in the pelvis and legs. In this study, we show that the eတ�ects of B0 and B1 oတ�sets aremanifested as arterial signal loss, stripe artifact and background signal variation. We develop multiple-refocused VS excitation pulsesand propose successive applications of two VS preparation pulses with shifted excitation proတတles to suppress these artifacts.

2687Computer #64

Dual-phase coronary MR angiography using image based respiratory navigationMarkus Henningsson and Rene Botnar

Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom

Image-based navigation (iNAV) is a promising respiratory motion correction approach for coronary MR angiography (CMRA). However,for dual-phase CMRA the technique may fail due to the diတ�erent cardiac motion states of the systolic and diastolic acquisition. Here wepropose the use of separate independent systolic and diastolic iNAV acquisitions to address this issue. We compared iNAV to theconventional diaphragmatic one-dimensional navigator (1D NAV) in 8 healthy subjects. The proposed technique achieves similar orimproved coronary vessel sharpness compared to 1D NAV while reducing dual-phase CMRA acquisition time.

2688Computer #65

FSE-based Non-Contrast-enhanced Magnetic Resonance Venography for evaluation of the upper extremity veins compared withContrast-enhanced MRV and UltrasoundRuth P Lim , Emma Hornsey , Dinesh Ranatunga , Huming Hao , Lucy McKenna , Julie Smith , Tim Spelman , Jason Chuen , andMark Goodwin

Radiology, Austin Health, Melbourne, Australia, Radiology, The University of Melbourne, Melbourne, Australia, Surgery, The University ofMelbourne, Melbourne, Australia, Surgery, Austin Health, Melbourne, Australia, Centre for Population Health, Burnet Institute, Melbourne,Australia

Venous mapping is important in end stage renal disease patients requiring vascular access for hemodialysis. We compare image quality(IQ) and measured vessel caliber of FSE based non-contrast MRV (NC-MRV) to contrast-enhanced MRV (CE-MRV) and US in availablesegments in 10 healthy volunteers. Central and arm vein IQ was diagnostic, but forearm vein IQ was suboptimal, inferior to CE-MRV. Nodiတ�erence in vessel caliber between sequences was demonstrated for most segments between NC-MRV and CE-MRV, but both MRVtechniques yielded signiတတcantly larger caliber measurements than US, raising concern regarding application of MRV-derivedmeasurements to clinical practice.

2689Computer #66

Imaging Deep Inferior Epigastric Perforators with Phase Contrast Magnetic Resonance Angiography: A Feasibility DemonstrationXiangyu Yang , Michael Miller , and Michael V Knopp

Radiology, The Ohio State University, Columbus, OH, United States, Plastic Surgery, The Ohio State University, Columbus, OH, United States

Currently, MRA is not considered the op[ mal technique for preopera[ ve imaging of perforators before flap reconstruc[ ve plas[ c surgeries. In thisprospec[ ve study, we demonstrate that the quality of perforator MRA can be greatly enhanced by using the phase contrast technique. Perforator imagingwith PC‐MRA not only generates images with beOer quality and contrast than X‐ray and iodinated contrast based CTA, the current clinical gold‐standard, but

1 2 2 2 3 3 2

4,5

1 2 3

4 5

1 2 3,4 5 6

1 2

3 4

5

6

1 1

1

1,2,3 1 1,2 4 1 1 5 3,4

1,2

1 2 3

4 5

1 2 1

1 2

also offers unique features, such as the capability to visualize venous flow and differen[ ate perforator arteries and veins, that are highly relevant to thedesign, planning, and execu[ on of DIEP flap reconstruc[ ve surgery.

2690Computer #67

Vessel-selective time-resolved cerebral angiograms in less than one minuteEleanor S K Berry , Peter Jezzard , and Thomas W Okell

FMRIB Centre, Nu�eld Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom

Vessel-encoded pseudo-continuous arterial spin labeling (VEPCASL) can be used to obtain vessel-selective time-resolved angiograms.Here we compare accelerated Cartesian and radial readouts to demonstrate the feasibility of speeding up their acquisition, enablingbetter prospects for use of the method in a clinical setting. It was possible to acquire 2D vessel-selective angiograms in less than oneminute. Accelerated (undersampled) radial acquisition consistently led to angiograms with higher signal-to-noise ratio and better qualityperipheral artery imaging versus accelerated Cartesian imaging.

2691Computer #68

Clinically-Acceptable Non-Contrast Thoracic MRA using 3D Radial k-space Sampling and Compressed SensingMarc D Lindley , Daniel Kim , Kristi Carlston , Leif Jensen , Daniel Sommers , Ganesh Adluru , Edward VR DiBella , Christopher JHanrahan , and Vivian S Lee

Physics, University of Utah, Salt Lake City, UT, United States, Radiology, UCAIR, University of Utah, Salt Lake City, UT, United States

As an alternative to contrast-enhanced (CE) MRA, we developed an accelerated non-contrast MRA of thoracic aorta using a combinationof T2-prepared and fat saturation preparations, b-SSFP readout, 3D radial stack of stars sampling with tiny golden angles, andcompressed sensing. This NC-MRA was compared with standard ECG-gated CE-MRA in 8 patients. Normalized signal diတ�erence andaortic diameters were not signiတတcantly diတ�erent between CE- and NC-MRA methods.

2692Computer #69

Non-Contrast MR Angiography with Arterial Spin Labeling: Initial Experience in Pediatric Patients With a 3D Spiral pCASL and CINEMAProtocolAmber Pokorney , Niccolo Stefani , Zhiqiang Li , Jonathan M. Chia , John Condie , Houchun Harry Hu , and Jeတ�rey H. Miller

Radiology, Phoenix Children's Hospital, Phoenix, AZ, United States, Philips, North America, Cleveland, OH, United States, Barrow NeurologicalInstitute, Phoenix, AZ, United States, Neurology, Phoenix Children's Hospital, Phoenix, AZ, United States

This pilot clinical study evaluates the diagnostic utility of a 3D spiral pCASL approach and a 3D dynamic PASL pulse sequence (i.e.,CINEMA) in evaluating the neurovasculature in pediatric patients. With increasing recent concerns over the possible deposition ofGadolinium in the brain, a viable clinical protocol that can supplant traditional contrast-enhanced MR angiography is particularlyrelevant to the pediatric population. Our clinical results in patients ranging from 1 year of age to adolescents demonstrate that both 3Dspiral pCASL and dynamic PASL are robust approaches and yield diagnostically useful information that supports clinical တတndings fromconventional TOF angiography.

2693Computer #70

Pseudocontinuous spin-labeled quiescent-interval slice-selective (QISS) magnetic resonance angiographyIoannis Koktzoglou , Marcos P Botelho , Shivraman Giri , Amit Pursnani , and Robert R Edelman

Radiology, NorthShore University HealthSystem, Evanston, IL, United States, University of Chicago Pritzker School of Medicine, Chicago, IL,United States, Northwestern University Feinberg School of Medicine, Chicago, IL, United States, Siemens Healthcare, Chicago, IL, United States,Medicine, NorthShore University HealthSystem, Evanston, IL, United States

To describe a pseudocontinuous arterial spin-labeled quiescent-interval slice-selective (pCASL QISS) pulse sequence for vessel-selectivenonenhanced MR angiography.

2694Computer #71

Clinically-Feasible Non-Contrast Abdominopelvic MRA using 3D Radial Stack-of-Stars k-space Sampling and Compressed SensingMarc D Lindley , Daniel Kim , Kristi Carlston , Leif Jensen , Daniel Sommers , Ganesh Adluru , Edward VR DiBella , Christopher JHanrahan , and Vivian S Lee

Physics, University of Utah, Salt Lake City, UT, United States, Radiology, UCAIR, University of Utah, Salt Lake City, UT, United States

Quadruple inversion-recovery (QIR), non-contrast (NC) MRA was developed as an alternative to contrast-enhanced MRA, and itperformance was evaluated in patients with peripheral arterial disease. The scan time for QIR with respiratory gating, however, is onthe order of 10-15 minutes. We sought to accelerate QIR using a combination of 3D radial stack-of-stars sampling with tiny goldenangles and compressed sensing (CS). This study shows that 5.3-fold accelerated QIR with radial k-space sampling and CS producesimages that are comparable to those produced by original QIR (e.g., 2.7-fold acceleration using GRAPPA). In 10 human subjects,normalized signal diတ�erence and vessel dimensions were not signiတတcantly diတ�erent between original QIR and 5.3-fold accelerated QIRwith radial k-space sampling and CS.

2695Computer #72

Pulmonary Magnetic Resonance Angiography: The direct and indirect တတndings of pulmonary embolism and their mimicsJohn Bisges , Scott K. Nagle , Christopher J. François , Peter Bannas , Michael D. Hope , J. Paul Finn , Karl Vigen , Thomas M. Grist , Scott

1 1 1

1

1,2 2 2 2 2 2 2

2 2

1 2

1 2 3 2 4 1 1

1 2 3

4

1,2 1,3 4 5 1,3

1 2

3 4

5

1,2 2 2 2 2 2 2

2 2

1 2

1 1 1 2 3 4 1 1

1 1

B. Reeder , and Mark L. Schiebler

Radiology, UW-Madison, Madison, WI, United States, Radiology, University of Hamburg-Eppendorf, Hamburg, Germany, Radiology, Universityof California at San Francisco, San Francisco, CA, United States, Radiology, University of California at Los Angeles, Los Angeles, CA, United States

The use of pulmonary magnetic resonance angiography (MRA) is playing an increasingly important role for the primary diagnosis ofpulmonary embolism (PE) and other causes of acute chest pain. We will deတတne appropriate imaging scenarios for the clinical use of thistest. Then, using a pictorial essay approach, we will demonstrate the various imaging features that: (A) directly indicates the presenceof PE; (2) indirectly suggests the presence of PE; (3) တတndings that directly show right heart strain; (4) indirect တတndings suggesting elevatedcentral venous pressure and most importantly; (5) those တတndings that can mimic PE. After review of these teaching cases, imaging physicians will be able to conတတdently make the diagnosis of PE on pulmonary MRA examinations.

Electronic Poster

Velocity & Flow QuantiတတcationExhibition Hall Monday, May 9, 2016: 10:45 - 11:45

2696Computer #73

Performance of Self-Calibrated Phase Contrast Correction in Pediatric and Congenital Cardiovascular MRIAna Beatriz Solana , Erin A. Paul , Ek Tsoon Tan , Amee M. Shah , Wyman W. Lai , Christopher J. Hardy , and Anjali Chelliah

GE Global Research, Garching bei Muenchen, Germany, Dept of Pediatrics, New York-Presbyterian Morgan Stanley Children's Hospital of NewYork, New York, NY, United States, GE Global Research, Niskayuna, NY, United States

Phase contrast (PC) MR တတow measurements are aတ�ected by multiple sources of error, including background phase oတ�sets. The gold-standard approach to correct these oတ�sets involves repeating PC measurements on a static phantom, prolonging each CMR study andimpeding exam workတတow. Here, we compared the performance of a self-calibrated correction to static-phantom corrected PC dataobtained from a pediatric and congenital heart disease population. Self-calibrated correction results showed strong agreement withphantom-corrected data for all vessel types and diတ�ered from static-phantom correction by a mean diတ�erence in Qp/Qs values of only0.069.

2697 Computer #74

Analysis and correction of eddy current induced artifacts in spiral phase contrast MRI using Point RESolved SpectroscopyRene Bastkowski , Kilian Weiss , David Maintz , and Daniel Giese

Department of Radiology, University Hospital of Cologne, Cologne, Germany, Philips Healthcare, Hamburg, Germany

A novel method based on single-voxel-spectroscopy (PRESS) for the analysis and correction of eddy-current induced artefacts in spiralphase-contrast MRI is presented. It is demonstrated, that 0th and 1st order corrections result in residual background oတ�sets of less than0.5cm/s, inherently correcting for geometrical misalignments between တတow acquisitions as well as 2nd order spatial phase oတ�sets. Themethod does not require special hardware and can be applied as a pre-scan.

2698 Computer #75

ktv-ARC reconstruction for 4D တတow MRI using correlations between velocity encodingsFatih Suleyman Hafalir , Ana Beatriz Solana , Peng Lai , Malek Makki , Anja C.S. Brau , Axel Haase , and Martin A. Janich

Technischen Universität München, Munich, Germany, GE Global Research, Munich, Germany, GE Healthcare, Menlo Park, CA, United States,MRI Research Center, University Children Hospital, Zurich, Switzerland, GE Healthcare, Munich, Germany

4D တတow MRI is a powerful tool for visualization and quantiတတcation of blood တတow. Repeated acquisition of 4 echoes with diတ�erent velocityencoding is needed to measure တတow in 3D. In this study, we propose a new ktv-ARC reconstruction by incorporating correlationsbetween velocity encoded echoes (v) to the spatiotemporal correlations (kt). The error behavior of the method was analyzed onretrospectively undersampled in vivo cardiac data and resulted in more accurate velocity images with ktv-ARC compared to kt-ARC.

2699Computer #76

Accuracy of relative pressure measurements from 3D PC-MR data using realistic aortic coarctation phantomsJesús Urbina , Julio Sotelo , Cristian Montalba , Felipe Valenzuela , Cristián Tejos , Pablo Irarrázaval , Marcelo Andia , IsraelValverde , and Sergio Uribe

Biomedical Imaging Center, Ponti�cia Universidad Católica de Chile, Santiago, Chile, School of Medicine, Ponti�cia Universidad Católica deChile, Santiago, Chile, Electrical Engineering Department, Ponti�cia Universidad Católica de Chile, Santiago, Chile, Radiology Department,Ponti�cia Universidad Católica de Chile, Santiago, Chile, Pediatric Cardiology Unit, Hospital Virgen del Rocio, Seville, Spain, Institute ofBiomedicine of Seville, Universidad de Sevilla, Seville, Spain

The aim of this work was to evaluate the accuracy of relative pressures obtained from 3D PC-MRI in a realistic aortic phantom withdiတ�erent grades of aortic coarctations at rest and stress conditions. We also evaluated the accuracy of the relative pressures whensubjected to diတ�erent aortic segmentation and spatial resolutions. The accuracy of the 3D PC-MRI is excellent compared withcatheterization values with mild to moderate AoCo at rest and stress conditions. Also, relative pressures were in excellent accuracy withcatheterization values when the aortic segmentation only included laminar တတow and with higher spatial resolution at rest and stressconditions. However, its accuracy decreases for severe AoCo cases.

1 1

1 2 3

4

1 2 3 2 2 3 2

1 2

3

1 1,2 1 1

1 2

1,2 2 3 4 5 1 2

1 2 3

4 5

1,2 1,3 1 1,3 1,3 1,3 1,4

5,6 1,4

1 2

3 4

5 6

2700Computer #77

4D တတow MRI-derived Wall Shear Stress Correlates with Vessel Wall Thickness: Atlases of the Carotid BifurcationPim van Ooij , Merih Cibis , Wouter V. Potters , Oscar H Franco , Meike Vernooij , Aad van der Lugt , Frank J Gijsen , Jolanda J Wentzel ,and Aart J Nederveen

Radiology, Academic Medical Center, Amsterdam, Netherlands, Biomedical Engineering, Erasmus MC, Rotterdam, Netherlands, Epidemiology,Erasmus MC, Rotterdam, Netherlands, Radiology, Erasmus MC, Rotterdam, Netherlands

The purpose of this study is to investigate if, already in early disease, a correlation exists between wall thickness (WT) and wall shearstress (WSS) in the carotid bifurcation. Eleven subjects with plaques in the left carotid arteries underwent 3D-တတow-MRI and proton-density-weighted-EPI for WSS and WT quantiတတcation, respectively. Relationships between WT and WSS were investigated on anindividual basis and using cohort-averaged maps (atlases). Spearman’s ρ averaged over all subjects was -0.28, which was signiတတcantlydiတ�erent from 0 (p

several cardiac MR parameters were diတ�erent between two diseases. After controlling for age and mean pulmonary arterial pressure,backward တတow ratio was the strongest diတ�erentiator of PAH from CTEPH. 4D တတow has a potential to visualize diတ�erent pulmonaryarterial hemodynamics according to etiologies in pulmonary hypertension.

2706Computer #83

4D တတow MRI Improves Computational Fluid Dynamics Analysis of Aortic DissectionSylvana García-Rodríguez , Jon Wrobel , Alejandro Roldán-Alzate , and Christopher J. François

Radiology, University of Wisconsin-Madison, Madison, WI, United States, Mechanical Engineering, University of Wisconsin-Madison, Madison,WI, United States

The effects of MRI‐derived three‐direc[ onal velocity profiles implemented at the inlet of aor[ c dissec[ on (AD) computa[ onal fluiddynamics (CFD) simula[ ons were inves[ gated. Two AD models were generated from in vivo MRA data using 3D prin[ ng. In vitro 4D FlowMRI was performed on the AD phantoms at two flow rates. Normal and mul[ direc[ onal blood flow vectors at the AD inlet was measuredfrom 4D Flow MRI data and used in CFD simula[ ons. Significant differences were found in pressure distribu[ on in response to inletboundary condi[ on defini[ ons. Peak velocity and wall shear stress were also affected by inlet condi[ on defini[ on.

2707Computer #84

4D တတow MRI derived energetic biomarkers are abnormal in repaired tetralogy of Fallot patients and may predict deterioratinghemodynamicsJoshua Daniel Robinson , Cynthia K Rigsby , Michael Rose , Susanne Schnell , Alex J Barker , and Michael Markl

Pediatric Cardiology, Ann & Robert H Lurie Children's Hospital, Chicago, IL, United States, Pediatrics, Northwestern University Feinberg Schoolof Medicine, Chicago, IL, United States, Medical Imaging, Ann & Robert H Lurie Children's Hospital, Chicago, IL, United States, Radiology,Northwestern University Feinberg School of Medicine, Chicago, IL, United States, McCormick School of Engineering, Northwestern University,Evanston, IL, United States

Tetralogy of Fallot (TOF) is the most common form of cyanotic heart disease. As life expectancy continues to increase, MRI plays acentral role in evaluation for post-operative complications and reintervention. Current assessment is based on simpliတတed parametersthat measure late expression of underlying physiologic changes, with poor outcome prediction. In this study, we explore quantitative 4Dတတow metrics which may be important measures of hemodynamic e†‐ciency. We found that energetic metrics are abnormal in TOFcompared to healthy controls. While these metrics correlated only modestly with routine measurements of ventricular e†‐ciency, theymay represent earlier biomarkers of disease progression.

2708Computer #85

Highly Accelerated 4D Flow MRI with CIRcular Cartesian UnderSampling (CIRCUS) in Patients with Intracranial AneurysmsJing Liu , Yan Wang , Farshid Faraji , Sarah Kefayati , Henrik Haraldsson , and David Saloner

University of California San Francisco, San Francisco, CA, United States, VA Medical Center, San Francisco, CA, United States

A highly accelerated 4D တတow MRI method with a high tempospatial resolution has been validated in healthy volunteers by comparing tothe conventional method. The proposed method been demonstrated to be very promising for imaging the patients with intracranialaneurysms, by achieving an isotropic resolution of 1.3mm and a temporal resolution of 26ms within a 5-minute scan time (R=12).

2709Computer #86

Non-Contrast Cardiac 4D Flow with Bright Blood and Improved Robustness Using Multiple Thin Slab Acquisition and Variable DensityRadial SamplingPeng Lai , Ann Shimakawa , Joseph Yitan Cheng , Marcus T Alley , Shreyas S Vasanawala , and Anja C.S Brau

Global MR Applications and Work�ow, GE Healthcare, Menlo Park, CA, United States, Radiology, Stanford University, Stanford, CA, UnitedStates, Global MR Applications and Work�ow, GE Healthcare, Munich, Germany

Cardiac 4D Flow suတ�ers from blood signal saturation due to whole-volume imaging and limited accuracy if acquired without contrastagents. This work developed and investigated a new multiple thin slab scheme for non-contrast whole-chest 4D Flow. With in-တတowenhancement and bright blood, the new sequence provides higher SNR and motion robustness than conventional 4D Flow. Theproposed radial golden angle view order ensures smooth slab merging that is insensitive to cardiac and respiratory variations duringthe scan.

2710Computer #87

Using MRI to Observe Increased Venous Flow Collateralization in Subjects with Anomalous Jugular VeinsSEAN KUMAR SETHI , Giacomo Gadda , Ana M. Daugherty , David T. Utriainen , Jing Jiang , Naftali Raz , and Ewart Mark Haacke

The MRI Institute of Biomedical Research, Detroit, MI, United States, Physics, University of Ferrara, Ferrara, Italy, Department of Gerontology,Wayne State University, Detroit, MI, United States, Biomedical Engineering, Wayne State University, Detroit, MI, United States

We have established in previous works that a subset of multiple sclerosis (MS) patients show abnormal structure and တတow in the internaljugular veins (IJV) when measured with MRI. In this retrospective analysis, we classiတတed and compared extracranial venous collateral တတowin MS and normal control samples using MR venography and Phase-contrast တတow quantiတတcation with a large, standardized dataset. Over50% of the MS cohort shows a jugular anomaly. The stenotic-MS group shows reduced Type I venous တတow compared to healthy controlsand non-stenotic MS, while having elevated Type II and Type III တတows.

1 1 1,2 1

1 2

1,2 3,4 3 4 4 4,5

1 2

3 4

5

1 1 1 1 1 1,2

1 2

1 1 2 2 2 3

1 2

3

1 2 3 1 1 3 4

1 2 3

4

2711Computer #88

Design and Validation of a Minimum Time Verse Pulse for 4D Flow MRIPatrick Magrath , Eric Aliotta , Shams Rashid , Yutaka Natsuaki , Xiaoming Bi , Zhe Wang , Kyung Sung , Peng Hu , HoldenWu , and Daniel B Ennis

Department of Radiological Sciences, University of California, Los Angeles, CA, United States, Department of Bioengineering, University ofCalifornia, Los Angeles, CA, United States, Physics and Biology in Medicine IDP, University of California, Los Angeles, CA, United States, SiemensHealthcare, Los Angeles, CA, United States

4D-တတow MRI is used to quantify blood တတow in a variety of neurovascular pathologies including intracranial aneurysms [1], but is limitedby long scan times as well as moderate spatial and temporal resolution. Conventional RF pulses have poor slab proတတles that contributeto low sequence e†‐ciency by increasing the တတeld-of-view needed to avoid aliasing in the slab direction. Our objectives were to design aminimum time, high Time Bandwith Product (TBW) VERSE pulse for 4D တတow and to validate the improvement in sequence e†‐ciency,conတတrm တတow accuracy, and evaluate total SAR deposition for VERSE+4D-တတow compared to our clinical 4D တတow imaging protocol.

2712Computer #89

Contrast-Enhanced 4D Flow Imaging with Reduced Fat SignalJoseph Y. Cheng , Tao Zhang , Adam B. Kerr , Michael Lustig , John M. Pauly , and Shreyas S. Vasanawala

Radiology, Stanford University, Stanford, CA, United States, Electrical Engineering, Stanford University, Stanford, CA, United States, ElectricalEngineering & Computer Sciences, University of California, Berkeley, CA, United States

Volumetric time-resolved velocity imaging (4D တတow) can be used as a single comprehensive sequence to quantify blood တတow, evaluatecardiac function, and assess anatomy. However, fat signal can reduce tissue contrast, introduce high-signal-intensity artifacts frommotion, and cause errors in velocity quantiတတcation. Two approaches are presented for reducing fat signal in contrast-enhanced 4D တတowimaging with minimal time penalty. The တတrst approach is a short spectral-spatial RF pulse that reduces fat signal below the level ofcontrast-enhanced blood pool. The second approach is the introduction of one additional echo with a diတ�erent TE to separate fat/waterfor all တတow encoding echoes. The performance of these approaches are evaluated in a static phantom study and in patient volunteerstudies.

2713Computer #90

The Communicating Arteries Redistribute Blood Flow in the Circle of Willis with Hypoplastic Segments: Intracranial 4D တတow MRI at 7 TeslaPim van Ooij , Matthan Caan , Bart M. W. Cornelissen , Henk A Marquering , Pieter Buur , Gustav J Strijkers , Jeroen Hendrikse , andAart J Nederveen

Radiology, Academic Medical Center, Amsterdam, Netherlands, Biomedical Engineering & Physics, Academic Medical Center, Amsterdam,Netherlands, Spinoza Center for Neuroimaging, Amsterdam, Netherlands, Radiology, University Medical Center Utrecht, Utrecht, Netherlands

In this study it was investigated if the communicating arteries redistribute blood တတow in the circle of Willis (coW) with hypoplasticarteries. For this purpose, 4D တတow MRI at 7 Tesla was used in ten healthy volunteers. 50% of the participants had a full coW, whereas50% had hypoplastic or missing segments. Signiတတcant correlations were found for time-averaged blood တတow (mL/s) between the left/right posterior communicating artery and the left/right posterior cerebral artery and between the anterior communicating artery andthe right anterior cerebral artery. This တတnding illustrates that တတow is redistributed through the communicating arteries in the coW.

2714Computer #91

Aortic hemodynamics in pediatric Marfan patients compared to healthy pediatric subjects: heterogeneity in the Marfan populationRoel LF van der Palen , Alex J Barker , Emilie Bollache , Michael J Rose , Pim van Ooij , Julio Garcia , Luciana Young , Arno AW Roest ,Michael Markl , Cynthia K Rigsby , and Joshua D Robinson

Department of Pediatric Cardiology, Willem-Alexander Children and Youth Center, Leiden University Medical Center, Leiden, Netherlands,Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States, Department of Medical Imaging,

Ann & Robert Lurie Children’s Hospital of Chicago, Chicago, IL, United States, Department of Radiology, Academic Medical Center, Amsterdam,Netherlands, Division of Pediatric Cardiology, Ann & Robert Lurie Children’s Hospital of Chicago, Chicago, IL, United States, Department ofBiomedical Engineering, McCormick School of Engineering, Northwestern University, Chicago, IL, United States, Department of Pediatrics, Ann &Robert Lurie Children’s Hospital of Chicago, Chicago, IL, United States

Marfan syndrome (MFS) is a connective tissue disease with high risk of aortic dissection/rupture. Two-thirds of dissections occur in theascending aorta, one-third in the descending aorta. Diameter plays an important role in risk stratiတတcation. However, recent literature hasshown diameter only accounts for 50% of the dissections in the descending aortic region. It is not well known how aortic hemodynamicsinteract with the altered vascular structure of these aortas and how it may impact dilatation. A cohort of MFS children and an ageappropriate control group were evaluated with 4D တတow MRI: already distinct abnormalities are present in childhood.

2715Computer #92

Model-based estimation of arterial pulse wave velocity from MRI velocity dataPrem Venugopal , Ek Tsoon Tan , Peter Lamb , Christopher J Hardy , and Thomas K Foo

GE Global Research, Niskayuna, NY, United States

Pulse wave velocity (PWV) is a commonly used

The VIP Cancer MR Session · Electronic Poster The VIP Cancer MR Session Exhibition Hall Monday,...

Documents

Transcript of The VIP Cancer MR Session · Electronic Poster The VIP Cancer MR Session Exhibition Hall Monday,...