The role of who in leg imaginal disc morphogenesis.
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The role of who in leg imaginal disc
morphogenesis
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The Drosophila who gene has pleiotropic functions
during metamorphosis• who (wings-held-out) also named how, struthio,
qkr93F• Encodes KH RNA binding protein • Strong similarity to nematode GLD-1 and mouse
QK1• Required for tendon cell differentiation in
embryos• who mutants exhibit defects in muscle, muscle
attachment, wing development and adult leg development
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who mutants show multiple lethal phases
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who is expressed during metamorphosis
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who mutants show defects in leg development
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who
Stubble
control
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Conclusions
• who mutants show multiple lethal phases and pleiotropic effects during metamorphosis.
• who is expressed during metamorphosis.
• who mutant leg discs undergo proper cell shape changes during morphogenesis but do not extend fully at the prepupal-pupal transition.
• This defect is associated with inappropriate orientation of leg imaginal discs.
• The pleiotropic function of who suggests that KH proteins play essential roles in development of numerous cell types.
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Acknowledgments
Mount Holyoke College
Tina Fortier
Craig Woodard
University of Maryland Biotechnology Institute
Runa Chatterjee
Susan Klinedinst
Eric Baehrecke
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