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HE ROLE OFHE ROLE OFRLISTAT INRLISTAT INREATMENT OFREATMENT OFOBESITYBESITY

NOOR SHAIKHNOOR SHAIKH

K0520724

K0520724

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I Will Cover...

A Brief introduction to obesity

Treatments Available

Background on Orlistat

Mechanism of action

Clinics trials

Advantage of using Orlistat

Adverse effect

Conclusion

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Obesity? A condition associated with the accumulation of excessive

body fat, which leads to a reduction in quality of life

Obesity is measured by the BMI (body mass index)

measured by the relationship between the wieght and

hieght of an individual.

An individual to be considered obese their BMI would be

greater than 30 kg/m2

Obesity is a global issue. Obesity affects 24% of adults

(over 16) and 16% of children (2-16) in England.

[statistics taken in 2006]

Obesity are linked to other diseases, such as:

hypertension, diabetes, cardiovascular diseases etc..

These obesity linked diseases are costing the NHS a large

amount of money and a solution is need to solve the

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,enetic hormonal,nvironmental- ,ocio economiculturalbehavioural atient shouldn t belamed for theyutcome of the!isorder

Medical management of obesity

ifestylemodifications /utrition diet hysicalactivity ehaviourmodification

PharmacotherapySurgery

3. Treatment options

2. Multiple causes

erious healthcost ajor risk factoror commonauses of death

1. Chronic disease

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Pharmacological treatment:( /Used in obese patient with BMI 27 kg m 2)o

o irst generation Drugs Most arewidthdrawn- -It was designed for long term therapy- mechanism of action appetite suppressants

- :shown numbers of unpleasant effects such as, ,valvular heart defects addictive safety problems.e g fenfluramine

o econd generation drugs- Orlistat and Sibutramine- there are inhibitor drugs

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Background on orlistat

. .Approved in the U S FDA in the 1999 and- -became available over the counter in the UK

on 21stof January 2009 under the name Allimarket by GSK

It is a synthetic drug (It is derived from lipstatin isolated from),a bacterium which is a natural pancreatic

.lipase inhibitor :Its structural formula

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Mechanism of action

o Gastric lipase inhibitor

o Works in the gut to prevent absorption

of fat decrease degradation of ingested

triglycerides into fatty acid

o -Non absorbed triglycerides excreted by gut

o %it blocks 30 of dietary fato

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Clinic trails

:S h o rt tra ils showed effectiveness of Orlistatw e ig h t lo ss in co m p a riso n to th e p la ce b o

:Lo n g tra ils

- 3 3 0 4 o b e se p a tie n ts in p la ce b o co n tro lle d tria l

- 4 ye a rs p e rio d

- %O rlista t tre a te d g ro u p h a d a 3 7 re la tive risk

re d u ctio n in d e ve lo p in g d ia b e te s co m p a re d to

.p la ce b o

- .O rlista t h e lp e d w e ig h t lo ss in th e p a tie n t

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Advantages of orlistato Highly potent

o A specific irreversible inhibitor of

pancreatic and gastric lipases

o -Highly lipophilic and is a non systemically

acting drug

o Successful in both weight loss and

maintenance

o Reduces total cholesterol levels

o Successful in treatment of type 2 diabetes

.patient

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Side effect of Orlistat

Gastrointestinal adverse events are the, :most common occurring it includes

, ,abdominal pain oily spotting faeces,fatty stool faecal incontinence and

faecal urgency -Decreased absorption of fat soluble

vitamin

May be linked to increase risk in cancer( )more studies needs to conducted

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Conclusion:

Obesity cannot be controlled or managedonly by the government or health. ,professionals The food industry

, ,international agencies the media

communities and individuals need to work

together so that the environment is less.conducive to weight gain

Pharmacological treatment using Orlistat

to treat obesity shown some evidence forthe short term effectiveness and future

researches are required on the issue of.its long term use saftey