The Role of Nutrition and Immune Support for Sports ... … · Kerry’s Proprietary Process • A...
Transcript of The Role of Nutrition and Immune Support for Sports ... … · Kerry’s Proprietary Process • A...
The Role of Nutrition and
Immune Support for Sports
Performance
Laura Collins PhD (Immunology)
Nutrition Analyst
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Agenda
• Immune health & the
consumer
• The impact of nutrition on
immune health
• Wellmune® overview and
new studies
Immune health & the
consumer
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Consumer Health & Wellness Consumers are evolving in their behavior by taking a proactive approach to health and wellness.
Vitality Taking Care Preventative Long-term Proactive
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Strong Demand for Immune Health Products
87% of consumers are interested in products with immune health benefits. Immune health is the #2 most desired benefit, behind only general
health & wellness.
87%
Source: Global Data 2015 survey of nearly 28,000 consumers in 31 markets. Q: “How interested are you in food or drink that provide the following
benefit…?”
100
90
80
70
60
50
40
30
20
10
0
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Immune Health & Consumers
A healthy immune system is important to everyone, but especially for:
Families with
Children
Athletes &
Weekend Warriors
Older Adults Anyone
Experiencing Stress
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Sources Of Variation In Immune Function
Immune
Function Gender
Age
Hormonal Status
Early Life Events
Obesity
Alcohol Consumptio
n
Exercise
Stress
Exposure to Pathogens Nutrient
Status (Diet)
Smoking
Genetics
British Journal of Nutrition (2002), 88, S165–S176
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The impact of nutrition
on the immune system
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Nutrition in the Immune System
There is already a defined role for nutrition in the Immune System.
• Undernutrition is related to decreased immune
function
• Overnutrition and related obesity can contribute
to chronic low grade inflammatory changes
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Immunity Relationships
Infection
Impaired Host Defense
Undernutrition
Interrelationship Between Undernutrition, Impaired Immunity And Infection
Proceedings of the Nutrition Society (2013), 72, 299–309
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Nutritional Interventions Have The Ability To Restore
“Optimal Immune Function”
‘Optimal Immune
Function’
Hyperactive Chronic Inflammation Allergies
Hypoactive Impaired Infection Resistance
‘Optimal Health’
‘Danger’
Pathogens, insults,
allergens, metabolic
stress…
• Ageing
• Diet
• Smoking
• Alcohol
• (Lack of) Exercise
• Sleep Deprivation
• Hygiene
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J-Curve Hypothesis
URTI incidence drops as exercise intensity
increases until it reaches an inflection
point and begins to increase as exercise
intensity increases from moderate to
“severe”.
Figure adapted from "Exercise, Upper Respiratory Tract Infection, and the Immune System." Medicine & Science in Sports & Exercise. (1994) 26:128-139.
Sedentary Moderate Prolonged/Intense
Low
Me
diu
m
Hig
h
Infe
ctio
n R
isk
Exercise Dose
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Modulating Immunity Through
Nutrition Interventions
Nutrition is one of the key
modifiable factors
• It is well defined that adequate
and balanced supply of nutrients
is essential for a healthy
functioning immune system
• It is an area of discovery for
nutritional interventions to aid
people with compromised
immune health
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Effectiveness of the Immune System…
…Can Be Impacted by What We Eat!
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Defined Immune Modulating Nutritional Factors
Protein
LCPUFA
Prebiotics
Vitamins – A, C, D, E
Minerals – Iron, Zinc, Selenium
Probiotics
Functional Ingredients - Wellmune®
Immunonutrition
Wellmune®
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Introducing Wellmune®
• Wellmune® is a natural food, beverage and supplement ingredient
clinically proven to help strengthen the immune system.
• A proprietary baker’s yeast beta 1,3/1,6 glucan, Wellmune makes it
easier for people of all ages to be well and stay well.
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What is Wellmune® and How Does it Work?
What is Wellmune?
Kerry’s Proprietary Process
• A natural form of beta 1,3/1,6 glucan found in
the cell wall of baker’s yeast.
• Purifies & strips away yeast cell wall.
• Gives body direct access to Wellmune.
How Does Wellmune Work?
• Consumed orally, Wellmune is taken up in the body by Peyer’s Patches in the intestines.
• Immune cells called macrophages (located in the Peyer’s Patches) ingest Wellmune and travel to the immune organs throughout the body.
• Macrophages break down Wellmune into smaller fragments that bind to neutrophils, the most abundant immune cells in the body.
• Primed by Wellmune, neutrophils move more quickly to recognize and kill foreign challenges.
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Clinical Research
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Wellmune® Clinical Studies
• 1402 healthy normal adults
– Physical stress studies (742)
– Psychological stress studies (372)
– Aging population (100)
– Other studies (188)
• 669 healthy children, ages 1-4
– Wellmune children’s study (156)
– Sponsored children’s studies (513)
Health benefit studies include over 2,000 adults and children.
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Wellmune® Clinical Studies
Reduction
in URTI
symptoms*
Improvement
in POMS
scores
Reduction
in allergy
symptoms
Wellmune physical &
psychological health benefits
# of
studies: 8 adults
2 children 3 adults
1 adult
1 child
URTI = Upper Respiratory Tract Infection POMS = Profile of Mood States
* Reduction is # subjects or days
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Wellmune® Clinical Research – Summary
Focus
Texas Marathon
Lifestyle Stress, 12 Weeks
Exercise Stress
Lifestyle Stress, 4 Weeks
Older Adults
Allergy
Cold/Flu
Children
Medical Students
Firefighters
Study Type Published
Health Effects & Biomarkers in Older Adults
Health Effects in Children
Physical Stress Health Effects
Biomarkers
Allergic Rhinitis Health Effects
Physical and Lifestyle Stress
Lifestyle Stress Health Effects
Lifestyle Stress Health Effects
Health Effects in General Population
California Marathon Physical Stress Health Effects
Physical Stress Health Effects
Nutrition, 2017
Journal of Nutrition & Food Sciences, 2016
Journal of Dietary Supplements, 2013
British Journal of Nutrition, 2013
Food Science & Nutrition, 2013
Nutrition, 2012
Journal of American College of Nutrition, 2012
Agro FOOD Industry Hi-Tech, 2010
Journal of Applied Research, 2009
Journal of Sports Science & Medicine, 2009
Presented at American Society of Sports
Medicine*, 2008
* Pending Publication
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Study: Older Adults
Study Protocol
Study Site
Population
Age
Design
Duration
Serving
University of Southampton School of Medicine, UK
100 healthy adults (54 men, 46 women)
50-68 (average 59 years)
Randomized, double blinded, placebo controlled, parallel arm study
90 days
Participants were split into two groups and consumed one of the following once daily: • 250mg Wellmune • placebo
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Study: Older Adults
Wellmune demonstrated a strong trend towards reducing the number of upper respiratory tract infections
(URTIs) and reducing symptom days of a cold. Participants taking Wellmune had:
4.5
4
3.5
3
2.5
2
1.5
1
0.5
0
16% decrease in total URTI
symptom days.
Wellmune Placebo
16% A
ve
rag
e n
um
be
r o
f sy
mp
tom
s
+
+ p=0.067, * p=0.016 “Yeast-Derived Beta 1,3/1,6 Glucan, Upper Respiratory Tract Infection and Innate Immunity in Older Adults.” (2017) Nutrition 39-40:30-35.
0
20
40
60
80
100
120
140
160
Baseline Day 0-45 Day 0-90
Interferon - γ
Wellmune Placebo
pg
/ml
Wellmune
Placebo
*
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Study: Texas Marathon
Study Protocol
Study Site
Population
Age
Design
Duration
Serving
Department of Health and Human Performance, University of Houston, USA
182 runners (96 men, 86 women) who completed the 2011 LiveStrong Marathon in Austin, Texas with an average finish time of 4 hours
29-46 (average 34 years)
Randomized, double blinded, placebo controlled, parallel arm study
4 weeks
Participants were split into three groups, and consumed one of the following once daily: • 250mg Wellmune soluble • 250mg Wellmune dispersible • placebo
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Study: Exercise Stress
Study Protocol
Study Site
Population
Age
Design
Duration
Serving
Department of Health and Human Performance, University of Houston, USA
60 recreational athletes (29 men, 31 women)
22-38 (average 23 years)
Randomized, double-blinded, placebo-controlled, crossover study
10 days supplementation with Wellmune or placebo; seven-day wash out period; 10 days supplementation with Wellmune or placebo.
Participants were split into two groups, and consumed the following once daily for 10 days, in two separate instances: • 250mg Wellmune
• placebo
Additional Study Details:
After the 10 day supplementation period, participants rode an exercise bicycle for one hour in a heat-stress chamber.
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Wellmune prevented the drop in white blood cells that occurs following intense exercise, and it supports immune
health in elite athletes by maintaining higher levels of LPS-stimulated cytokines.
Study: Exercise Stress
2600
2550
2500
2450
2400
2350
2300
2250
Wellmune
Placebo
pg
/ml
Interferon-γ
Baseline Pre Post 2h
9100
9050
9000
8950
8900
8850
8800
8750
Wellmune
Placebo
pg
/ml
Interleukin-4
Baseline Pre Post 2h
*
*
*
*
*p≤0.05, **p≤0.01, ***p≤0.001 “Baker’s Yeast ß-glucan Supplementation Increases Monocytes and Cytokines Post-Exercise: Implications for Infection Risk?” (2013) British Journal of Nutrition109:478-486.
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Two hours post-exercise, Wellmune improved salivary IgA recovery by 32% compared to the placebo, thus
helping IgA levels rebound more quickly.
Study: Exercise Stress
40
35
30
25
20
15
10
5
Wellmune
Placebo
pg
/ml
Salivary IgA
Baseline Pre Post 2h
*
*p≤0.05, **p≤0.01, ***p≤0.001 “Baker’s Yeast Beta Glucan Supplementation Increases Salivary IgA and Decreases Cold/Flu Symptomatic Days After Intense Exercise.” (2013) Journal of Dietary Supplements 10:171-183.
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Study: Exercise Stress
HEALTHY
ZONE
CHALLENGE
ZONE
Many immune biomarkers show a quick drop that lasts
for 2-6 hours following exercise.
“Open Window Effect”
Wellmune Placebo
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Meeting the Immune Health Needs of Today
• Consumers are taking a proactive approach to
health & wellness – using foods, beverages and
supplements to help with their goals.
• Immune health is the foundation of overall wellness –
good nutrition is essential to a strong immune system.
A healthy immune system is important to everyone,
but especially for children, athletes and the elderly.
• There is a well defined role for nutrition in supporting
the immune system
• Wellmune ® has been clinically proven to support a
large array of life stages such as children, athletes
and the elderly.
http://www.eatright.org/resource/health/wellness/preventing-
illness/protect-your-health-with-immune-boosting-nutrition