The Research Revolution Will not be Televised
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Transcript of The Research Revolution Will not be Televised
Clinical and Translational Science Seminar Series12/12/12
Richard J. [email protected]
@rbookman
^
but it will be tweeted
research
“The United States is in the midst of a profound reorganization of how research is done, where it is done, who does it, and how its results find their way to the marketplace.”
opening sentence ofTransformation and Opportunity: The Future of the U.S. Research Enterprise, by the President’s Council of Advisors on Science and Technology (PCAST)November 30, 2012http://www.whitehouse.gov/sites/default/files/microsites/ostp/pcast_future_research_enterprise_20121130.pdf
NIH Purchasing Power – 2003-2013
2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 Senate
$18
$20
$22
$24
$26
$28
$30
$32
$27.1$27.9 $28.5 $28.5
$29.0 $29.3
$30.5$31.0 $30.7 $30.6 $30.7
$26.9 $26.4
$25.3$24.8
$23.9 $24.2$23.9
$23.0$22.4
$21.9
Current Constant (BRDPI)
Bill
ion
s
Labor-HHS BA only
Sources: NIH Budget Office; House and Senate Appropriations Committees
NIH Purchasing Power – 2003-2013
Labor-HHS BA onlySources: NIH Budget Office; House and Senate Appropriations Committees
Nature 477, 526-528 (2011) | doi:10.1038/477526a
Over the past decade, before pursuing a particular line of research, scientists (including C.G.B.) in the haematology and oncology department at the biotechnology firm Amgen in Thousand Oaks, California, tried to confirm published findings related to that work. Fifty-three papers were deemed 'landmark' studies. It was acknowledged from the outset that some of the data might not hold up, because papers were deliberately selected that described something completely new, such as fresh approaches to targeting cancers or alternative clinical uses for existing therapeutics. Nevertheless, scientific findings were confirmed in only 6 (11%) cases. Even knowing the limitations of preclinical research, this was a shocking result.
our challenge
“Institutions seek to preserve the problem for which they are the solution.”
- Clay Shirky
From G. Dyson, Turing’s Cathedral, 2012
John von Neumann at IAS, Princeton, 1945
2012: a tipping point year?
50% of all US book* sales are e-books
Online movie views surpass in-theatre views
3-D printers fall below $1000
Majority of computers sold are smartphones
* non-textbook sales
& self-replicate!
the internet of things
big data
^
every
\
http://doi.ieeecomputersociety.org/10.1109/MIS.2009.36
disintermediation
reintermediation
open platforms:weatherGPSgoogle maps
re-useful is the new useful
Research 3.0who’s doing research?
how is research organized?
how is research communicated?
who’s paying for research?
open platforms for
collaborative discovery
Terms of UseSee this page for info, including copyright
how are these trends playing out in clinical research ??
Randomized controlled trial
vs.
Observational trial
open platforms for
collaborative discovery
http://www.pnas.org/content/105/6/2052
Methods
http://www.pnas.org/content/105/6/2052
http://www.nature.com/nbt/journal/v29/n5/full/nbt.1837.html
AbstractPatients with serious diseases may experiment with drugsthat have not received regulatory approval. Online patient communities structured around quantitative outcome datahave the potential to provide an observational environmentto monitor such drug usage and its consequences. Herewe describe an analysis of data reported on the website PatientsLikeMe by patients with amyotrophic lateral sclerosis (ALS) who experimented with lithium carbonate treatment.To reduce potential bias owing to lack of randomization, we developed an algorithm to match 149 treated patients to multiple controls (447 total) based on the progression of their disease course. At 12 months after treatment, we found no effect of lithium on disease progression. Although observational studies using unblinded data are not a substitute for double-blind randomized control trials, this study reached the same conclusion as subsequent randomized trials.
http://www.nature.com/nbt/journal/v29/n5/pdf/nbt.1837.pdf
http://artisopensource.net/cure/
“If patient engagement were a drug, it would be the blockbuster
drug of the century and malpractice not to use it.”
Leonard Kish
http://www.hl7standards.com/blog/2012/08/28/drug-of-the-century/
Research 3.0who’s doing research?
how is research organized?
how is research communicated?
who’s paying for research?
design
spe
c
^
but it will be tweeted
research