The Physiology of Immunity
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Transcript of The Physiology of Immunity
THEPHYSIOLOGY
OF IMMUNITY
_______________________
THEPHYSIOLOGY
OF IMMUNITY
_______________________
Delfin Arnel D. Razon, MD., DPBA
Department of Medical Physiology
Pamantasan ng Lungsod ng Maynila
College of Medicine
Delfin Arnel D. Razon, MD., DPBA
Department of Medical Physiology
Pamantasan ng Lungsod ng Maynila
College of Medicine
Cells Mediating the Immune Response:
Cells Mediating the Immune Response:
Leukocytes granulocytes
monocytes lymphocytes
B cellsT cells
cytotoxic T cellshelper T cellssuppressor T cells
NK cells Plasma cells Macrophages Mast cells
Leukocytes granulocytes
monocytes lymphocytes
B cellsT cells
cytotoxic T cellshelper T cellssuppressor T cells
NK cells Plasma cells Macrophages Mast cells
IMMUNE SYSTEM
Innate immunity Acquired immunity defences at body surfaces
phagocytosis Humoral Immunity
inflammation Cellular Immunity
complement activation
IMMUNE SYSTEM
Innate immunity Acquired immunity defences at body surfaces
phagocytosis Humoral Immunity
inflammation Cellular Immunity
complement activation
PHAGOCYTOSISPHAGOCYTOSIS
• 3 Important Cells 1. Neutrophils
Circulating pool
Marginated pool
.respiratory burst
.signal transduction/stimulus response
coupling
2. Circulating monocytes
3. Fixed tissue macrophages
• 3 Important Cells 1. Neutrophils
Circulating pool
Marginated pool
.respiratory burst
.signal transduction/stimulus response
coupling
2. Circulating monocytes
3. Fixed tissue macrophages
ACUIRED IMMUNITY(ADAPTIVE IMMUNITY)
ACUIRED IMMUNITY(ADAPTIVE IMMUNITY)
• LYMPHOCYTES• T-cells• B-cells
.plasma cellsIgG IgDIgA IgEIgM
. NK cells
• RECEPTORS• recognition
• LYMPHOCYTES• T-cells• B-cells
.plasma cellsIgG IgDIgA IgEIgM
. NK cells
• RECEPTORS• recognition
HUMAN T cellHUMAN T cell
Human ImmunoglobulinsAntibody Location Function
IgA Gut, respiratory tract and urogenital tract mucosa
-prevents colonization of pathogens -localized protection in external secretions
IgD Antigen receptor on B cells IgE - complement fixation
majority of Ab based immunity
-binds to allergens and triggers histamine release -involved in allergy protection vs parasitic worms
IgG - - complement fixation - majority of Ab based immunity
IgM Surfaces of Bcells/secreted form
- Complement fixation
- Pathogen elimination in early stages of B cells response
T cell responseANTIGEN PRESENTATION
T cell responseANTIGEN PRESENTATION
• APCs• MHCs
MHC class I- all nucleated cells of
the body
MHC class II- macrophages, macro-
phage-like cells, B cells• MHC restrictions
Helper T cells = MHC class II restricted
Cytotoxic Tcells = MHC class I restricted
• APCs• MHCs
MHC class I- all nucleated cells of
the body
MHC class II- macrophages, macro-
phage-like cells, B cells• MHC restrictions
Helper T cells = MHC class II restricted
Cytotoxic Tcells = MHC class I restricted
NK cells physiologic role
CLONAL DELETION
And
CLONAL INACTIVATION
CLONAL DELETION
And
CLONAL INACTIVATION
ENDEND