The organization of the nervous system

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The organization of the nervous system

description

The organization of the nervous system. Structure of the human cerebral cortex. Structure of the human cerebral cortex. Sensory map. Structure of the human cerebral cortex. Motor map. Neuromuscular junction. Neuromuscular junction. How to manipulate it ?. Curare. ACh-ase inhibitors . - PowerPoint PPT Presentation

Transcript of The organization of the nervous system

Page 1: The organization of the nervous system

The organization of the nervous system

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Structure of the human cerebral cortex

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Structure of the human cerebral cortex

Sensory map

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Structure of the human cerebral cortexMotor map

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Neuromuscular junction

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Neuromuscular junction

How to manipulate it ?CurareACh-ase inhibitors Myastenia gravisBotulinum toxinPesticides

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Parkinson’s diseaseBasal ganglia

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Parkinson’s diseaseMost common symptoms

Shaking (tremor) at Rest

Stiffness (rigidity)

Slow Movement (bradykinesia)Balance Problems (postural instability)

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Multiple sclerosis

Myelin

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Multiple sclerosis

Demyelination

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Multiple sclerosisProgression

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AMLAmyotrophic Lateral Sclerosis

(Lou Gherig disease”)

Mutation or defect in neuronal SOD activity

Excess oxidative stress to neuronal mitochondria

Degeneration of motor neurons

Paralysis – muscular atrophy

Exacerbated by glutamate neurotransmitter activity