The OPALS Prehospital Prehospital Research Group · The OPALS Prehospital . Prehospital Research...
Transcript of The OPALS Prehospital Prehospital Research Group · The OPALS Prehospital . Prehospital Research...
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Annual Meeting Ottawa 2007
The OPALS The OPALS PrehospitalPrehospital ResearchResearch
GroupGroup
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OPALS
OPALS PRG
Thank you to all our members!
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OPALS
OPALS PRG Members
• Ottawa Health Research Institute and DCC• MOHLTC and 10 Base Hospital Programs• 14 EMS Services• 16 Fire Departments• 15 cities with population of 2.5 million• Resuscitation Outcomes Consortium
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OPALS
OPALS Study Cities
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OPALS
OPALS Prehospital Research Group
Cambridge: Dave Waldbillig, Kieran Ballah, Lori Smith, Nilla Dutrisac, Jane SeifriedHalton: Matt Stempien, Ann Wilson, Mediha KadicKingston: Andy Reed, Mark Halladay, Rosie Hawkins Susan Duncan, Sandra BrennanLondon: Jon Dreyer, Ken Boyle, Gord Kinney, Joanne Kehoe, Nancy DensmoreNiagara: Doug Munkley, Lorie Luinstra-Toohey, John Wultchyn, Greg Soto, Carol DeGiuli, Lori Ann Parker, Dee Crozier, Jill Banbury
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OPALS Prehospital Research Group
Ottawa: Justin Maloney, Richard Dionne, John Trickett, Jeanny Verdon, Cynthia Norris, Sabrina Lawton, Sarah Munroe, Deanna Schofield, Susan Bartlett-Arsenian, Jennifer Guibord, Jason Rouleau, Kristy Smaggus, Susan Vokey, James MarkiSarnia: Martin Lees, Bob De Raad, Judy Potter, Michelle SmithSudbury: Paul Colella, Nicole Sykes, Pam Labelle, Trevor Love
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OPALS Prehospital Research Group
Thunder Bay: Andrew Affleck, Elaine Graham, Jessica Dykes, Kristine Perrier, Chrissy Klass, Dana KolodzidegczakWindsor: Paul Bradford, Cathie Hedges, Sandra Slogan, Mike Gobet, Chris Fader, Suzanne McKenzie, Linda Purcell
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Thank You EMS Service Staff
Region of Waterloo: Roger Mayo
Prescott-Russell: Louis Rathier, Gilles Lacroix, Yves Lariviere, Roxanne Bourdeau, Patrice Brennan, Mario Periard, Marc-Andre Periard, Natalie Nadeau
Halton Region: Greg Sage
Frontenac Paramedic Service: Paul Charbonneau, Susan Brown
Thames EMS: Bob Hopper, Dave Goddard
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Thank You EMS Service Staff
Niagara Region EMS: Hal KlassenOttawa Paramedic Services: Anthony Di Monte, Pierre Poirier, Peter Kelly, Stephanie Mills, Andrew Orchard, Mike Dupuis, Clayton Foster, Saleh HashemLambton EMS: Jeff Brook, Sandra KearnsGreater Sudbury EMS: Jennifer Amyotte, Tim Beadman, Tom IsaiaSuperior North Emergency and Rescue: Norm Gale, Wayne Gates
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Thank You EMS Service Staff
Sun Parlour EMS: John RutgersAmherstburg Anderdon & Maiden: Chris Grant, Brian BirdfellHarrow Ambulance: Michael SmithEssex County EMS: Dean Wilkinson
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Thank You Fire Service Staff
Burlington: Mark Alderman
Cambridge: David Greenhough
Kingston: Neville Murphy, Clint Long, Harold Tulk
London: Brian Arnold, Gwen Frances
Niagara: Jim Boutilier
Oakville: Al Kentie
Ottawa: Phil Muggleton, Don Thompson, Bruce Montone
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Thank You Fire Service Staff
Sarnia: Dave Hanley, Pat Cayen, John Kingyens, Rick MacGregor, Doug McKenzie, Dana PittsSudbury: Gordon StaufferThunder Bay: John Hay, John Mill, Rod HurdonWaterloo: Ryan SchubertWindsor: Mike Mio, John Quennell, Curtis Fedoruk
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OPALS PRG Steering Committee
Dr. Ian Stiell Chair and Scientific DirectorDr. George Wells Scientific AdvisorMs. Cathy Clement Research ManagerDr. Justin Maloney OPALS Med Director RepMr. John Trickett OPALS Prog Director RepDr. Jon Dreyer OBHG Med Director RepMr. Tony Campeau MOHLTC RepMr. Ken Boyle OBHG Prog Director Rep
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OPALS PRG Steering Committee
Dr. Jim Christenson At Large MemberMr. Anthony Di Monte At Large MemberMs. Lorie Luinstra-Toohey At Large MemberDr. Doug Munkley At Large MemberDr. Martin Osmond At Large MemberDr. Christian Vaillancourt At Large Member
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Thank You Ottawa D.C.C. Staff
Cathy ClementJane BanekTammy BeaudoinJulie CumminsIrene HarrisHeather BobierLinda McDonaldAngela MarcantonioMarc-Andre Da PontiMy-Linh Tran
Vanessa Baillie Sheryl DomingoWayne LoweChristine TymJulie FoxallMary-Jo LewisTracy McArdleIrene WatpoolElizabeth Anderson
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Thank You to Our Invited Guests
Berit Bardarson Seattle DCCDr. Dan Davis San DiegoDr. Clif Callaway PittsburghDr. Sheldon Cheskes Peel RegionDr. Jim Christenson VancouverSarah Pennington VancouverBarb Boychuk VancouverHelen Connolly VancouverDug Andrusiek Vancouver
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OPALS
Thank you to our Sponsors !
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What Has the OPALS Study Taught us What Has the OPALS Study Taught us About the About the
PrehospitalPrehospital Care of Critically Ill and Care of Critically Ill and Injured Patients?Injured Patients?
OPALS Annual Meeting Ottawa 2007
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The Ontario Prehospital Advanced Life The Ontario Prehospital Advanced Life Support StudySupport Study
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The OPALS Study
The largest prospective pre-hospital study yet conductedEvaluates the impact of rapid defibrillation and ALS programs on survival and morbidity
Over 9 years (1994-2003) involved 36,000 patients:4
Cardiac arrest (10,000)4
Major trauma (3,000)4
Respiratory distress (8,000)4
Chest pain (13,000)4
Pediatrics (2,000)
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OPALS
Primary Objectives
1. Cardiac Arrest:1. Cardiac Arrest: The incremental benefit for The incremental benefit for survival of adding rapid defibrillation programsurvival of adding rapid defibrillation program Phase II - JAMA 1999
2. Cardiac Arrest:2. Cardiac Arrest: The incremental benefit of adding The incremental benefit of adding ALS program ALS program Phase III – New Engl J Med 2004
3. Respiratory:3. Respiratory: The incremental benefit of ALS incremental benefit of ALS Phase III – New Engl J Med 2007
4. Trauma, Chest Pain, Pediatrics:4. Trauma, Chest Pain, Pediatrics: The incremental incremental benefit for survival/morbidity of adding ALS benefit for survival/morbidity of adding ALS Phase III – Not yet published
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Secondary Objectives: Cardiac Arrest1. Modifiable factors affecting survival1. Modifiable factors affecting survival
Ann Emerg Med 19992. EMS2. EMS--witnessed caseswitnessed cases
Ann Emerg Med 20003. Survival with only CPR?3. Survival with only CPR?
Ann Emerg Med 20014. Quality of life of survivors4. Quality of life of survivors
Circulation 20035. Optimal 5. Optimal DefibDefib Response Interval Response Interval
Ann Emerg Med 20036. Locations of arrest and PAD6. Locations of arrest and PAD
Can J Card 20047. Coroner7. Coroner’’s Diagnosis Pediatric CAs Diagnosis Pediatric CA
Resusc 2007
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OPALS
OPALS: Setting and Design
Multicenter before-after controlled clinical trial 21 Canadian cities Multiphase design:
Phase I Baseline (36 mo.)Phase II Rapid Defibrillation (12 mo.)Phase III Full ALS (36 mo.)
Interventions:Rapid defibrillation (II)Endotracheal intubationIV linesIV fluids & drugs
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OPALS
Defib at scene < 8 min 94%ALS paramedic at scene 93%ALS paramedic 11 min 87%Successful intubation 94%Successful IV insertion 85%
Cardiac Arrest ALS Response Targets
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OPALS
Improved OutImproved Out--ofof--hospital Cardiac hospital Cardiac Arrest Survival Through the Arrest Survival Through the
Inexpensive Optimization of an Inexpensive Optimization of an Existing Defibrillation ProgramExisting Defibrillation Program
Stiell, Wells, Field, et al Stiell, Wells, Field, et al for the OPALS Study Groupfor the OPALS Study Group
JAMA 1999JAMA 1999
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% of Cases Reached with Defibrillator in 8 Minutes or Less
77% 76% 78%
85%
93% 94%
78%
70%
100%
1991
1992
1993
1994
1995
1996
1997
Year
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Firefighters Arrived First with Defibrillator
0% 2%10%
21%
45%
1%0%
25%
50%19
91
1992
1993
1994
1995
1996
1997
Year
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Patient Survival
3.9%
5.2%
3%
6%33% Increase
P<.05
Phase I Phase II
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OPALS
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OPALS
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OPALS
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OPALS
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Primary Outcome: Overall Mortality
14.7%
12.1%
10%
15%
Before After
P < 0.01RR = 17.9%
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OPALS
Overall Impact of ALS in Study Communities (N = 2 Million)
Additional lives saved / year 173
Number needed to treatto save a life 38
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OPALS
Chest Pain: Overall Mortality (N=10,371)
P < 0.05RR=27.9%
0%
6%
Before After
4.3%
3.1%
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OPALS
Mortality by Diagnosis Subgroups
0%
20%
Mortality
MI Angina
P < 0.01RR=48.6%
P=0.97
17.3%
8.9%
2.2% 2.2%
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OPALS
Major Trauma: Overall Survival (N=2,884)
50%
75%
100%
BLS ALS
81.9% 81.2% P = 0.63
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Age - years
ISS score
Rev Trauma Score
Response time - min
ALS Phase
0.1 101
Adjusted Odds Ratios for Mortality H-L G of Fit P = 0.44
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OPALS
Subgroup GCS < 9: Overall Survival (N=664)
25%
50%
75%
BLS ALS
59.6% 51.0%
P = 0.03AD = - 8.6
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OPALS
Age - yearsISS score
GCS initialResponse time - min
IV in field
0.1 101
Adjusted Odds Ratios for Mortality H-L G of Fit P = 0.03
Intubation in field
SBP initial
2.4
1.3
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OPALS
Summary of Evidence from the OPALS Study: Cardiac Arrest
Bystander CPR (2nd Link) increases survival 3-4xRapid defibrillation (3rd Link) increases survival 3xALS (4th Link) no clear additional benefitPAD has limited potential impactQuality of life of survivors very good
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OPALS
Summary of Evidence from the OPALS Study: Critically Ill Patients
Respiratory Distress:Clear benefit from ALSMost important treatments not clear
Chest Pain:Also clear benefit from ALSWhich drugs most useful?
Major Trauma:No benefit and potential harm from ALS
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OPALS
Thank you to our Sponsors !
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The OPALS The OPALS Prehospital Research GroupPrehospital Research Group
OPALS PREHOSPITAL RESEARCH GROUP
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