THE NUVASIVE® APPROACHThe energy of a start-up. The experience of success.

SUCCEEDING WITH SPEEDOur Adventure Begins

Since the year 2000, NuVasive® has grown at an extraordinary rate. NuVasive has supported surgeons, improved the lives of patients and achieved results in all areas of business, thanks to a unique combination of factors. Speed of Innovation®. Technological advancement. Superior clinical outcomes. Absolute Responsiveness®.

A distinct performance culture. And an incredible and dedicated team of A Players focused on results.

NuVasive launched from a start-up venture capital-backed company to number five in the global spine industry, with over 80 products in our portfolio and revenue of $620.3 million. How did we accomplish this in just a little over a decade?

We attribute much of our success to our unyielding focus on our mission as well as our top three priorities. They guide our vision, determine our actions and drive our results.

Our Top 3 Priorities

Perpetuate our creative start-up edge to be the best through:• Speed of Innovation® • Absolute Responsiveness ® • Superior Clinical Outcomes

Advance Outstanding Performance Culture to Achieve Results

Increasing Global Market Penetration with Cost Efficiencies

OUR mISSION

Revenue with Increasing Profitability

1

Industry Leading Products and Services2 Evolve Our Culture

and Infrastructure 3Innovate to Make our Own

Products Obsolete

Reduce Costs and Launch Game-Changers

Transforming the quality of patient health care.

COmPETING WITH AN EDGESpeed of Innovation®

What establishes NuVasive® as a leader in the spine industry is our unique focus on Speed of Innovation. Since our inception, NuVasive has recognized that speed, combined with responsiveness, was what our surgeon-customers desired most. We knew that many of our larger competitors were too bureaucratic to move at our rapid pace, so this became our unique value—and has remained our edge ever since. We stand apart from the rest because of our commitment to produce a variety of new and innovative products each year, to be absolutely responsive to

our surgeon customers’ needs, and to build a team and environment that facilitates speed and innovation.

Our surgeon customers also want to partner with a company whose products produce superior clinical results. High quality is not sufficient in this environment. Surgeons want game changers: innovative products that truly transform the quality of patient health care–and at reasonable costs.

In October 2011, NuVasive announced its acquisition of Impulse® Monitoring, Inc., a leading provider of outsourced intraoperative monitoring to hospitals and healthcare facilities. The partnership of NuVasive and Impulse combines best-in-class products and procedures with industry-leading service to meet the needs of our customers, and ultimately, their patients.

As NuVasive grows and expands, we maintain our commitment to speed and innovation. We now provide the best of both worlds: the speed and responsiveness of a start up with the experience and resources of a larger company. This is why we created the goal to be the first $1 Billion Start-Up™.

lEADING THE INDUSTRyMaximum Access Surgery

NuVasive® has redefined spine surgery through our Speed of Innovation® and superior clinical outcomes–and everyone involved benefits from our approach. The surgeon can perform the procedure in a shorter amount of time. The patient experiences a speedier recovery. And the hospital has lower costs because patients recover more quickly with fewer complications.

We have changed the way spine surgery is being performed through our innovations: our minimally disruptive Maximum Access (MAS®) platform, our revolutionary nerve avoidance monitoring system (NVM5®), our innovative solution to a safe and reproducible lateral access surgery (XLIF®) and our growing number of offerings of biologics, cervical and motion preservation products.

Over the past decade, NuVasive has built an entire spine franchise, developing more than 80 products spanning lumbar, thoracic and cervical applications as well as neuromonitoring services. Our products have been used in hundreds of thousands of spine surgeries. Those are more than just impressive numbers—they represent improving the daily lives of patients.

SOLAS® currently has over 500 members

SUPPORTING OUR SURGEONSEducation and Training

Our numerous products and reproducible surgical procedures are complemented by our development of surgeon education programs and training. We provide basic and mastery courses, and also offer fully operational O.R. labs in our East and West Coast offices for surgeon training.

To further promote research and surgeon education, we established and continue to fund an elite organization of the most accomplished lateral access surgeons: SOLAS, the Society of Lateral Access Surgery. SOLAS currently has over 700 members, and continues to grow in number and reputation.

“I suffered from chronic back pain for more than 37 years. Now I have my life back.” – Bill Walton, Basketball Hall-of-Famer

FOCUSING ON PATIENTSEducation and Awareness

Our ultimate focus is on the people who need our products and procedures. Improving the lives of patients who suffer from debilitating back pain is what drives us to create products and procedures that truly make a difference.

With the goal of providing support to individuals suffering from back and leg pain, we created

The Better Way Back® program. This program is dedicated to building a community that provides hope and support to patients suffering from chronic back and leg pain, and inspires them to live successfully. We remain committed to raising awareness of spine disorders and educating patients and clinicians about surgical treatment options.

“Our company’s distinct culture gives us the ability to surpass our competitors...”

THRIVING THROUGH TEAmWORKOur Performance Culture

Another contributor to our success is our continued focus on building and evolving a performance culture that shapes who we are and how we achieve results.

Our company’s distinct culture gives us the ability to surpass our competitors and establish an aggressive approach that enables

us to overcome competitive challenges. It creates a unique edge that not only influences how NuVasive® conducts business, but also drives how we make decisions and surpass our goals. Our culture achieves results, and results fuel our culture.

ACHIEVING AND EXCEllINGOur A Players

Our culture is built around the contributions of many, each individual understanding their role and contributing to the collective success. We call our employees Shareowners, because that’s exactly what they are–owners who embrace our culture of teamwork, innovation and high expectations. Internally, we use the symbol of the cheetah to represent our reputation for speed and agility.

While other companies may focus on customer service, we take it to the next level and focus on

Absolute Responsiveness®. Our competition trains team members on their products and procedures, but NuVasive® ensures that each and every individual, from the IT help desk, to the accounting team, to the sales representatives in the field, is trained not just in our product offerings, but is an expert in spine with a comprehensive NUVA Spine Exam.

“...we use the symbol of the cheetah to represent our reputation

for speed and agility.”

GIVING BACKOur Attitude of Gratitude

We go beyond the creation of our products and services to reach out to those in need, helping people with serious back and leg pain regain their lives.

The NuVasive Spine Foundation™ is committed to changing lives by bringing world-class surgeons and innovative spine surgery to

disadvantaged communities across the globe. Through funding requests by our network of spine surgeons and other charitable organizations, we have innumerable opportunities to provide assistance to people in need.

“...we have innumerable opportunities to provide assistance to people in need.”

DEFINING THE DIFFERENCEThe Power of NuVasive®

Through our tremendous growth and experience over the past ten years, our fundamental focus hasn’t changed. The power of our NuVasive mission, priorities, and performance culture drive us to achieve extraordinary results at extraordinary speed, allowing us to continue to improve patients’ lives around the world.

“...tremendous growth and experience over the

past 10 years...”

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NuVasive®, Inc.7475 Lusk BoulevardSan Diego, CA 92121

© 2013. NuVasive, Inc. All rights reserved. , NuVasive, Speed of Innovation, Absolute Responsiveness, MAS, NVM5, SOLAS, The Better Way Back, and XLIF are federally registered trademarks of NuVasive, Inc. $1 Billion Start-Up and NuVasive Spine Foundation are common law trademarks of NuVasive, Inc. Impulse is a federally registered trademark of Impulse Monitoring, Inc.

To order, please contact your NuVasive Sales Consultant or Customer Service Representative today at:

NuVasive, Inc., 7475 Lusk Boulevard, San Diego, CA 92121 Tel 800.475.9131 Fax 800.475.9134WWW.NUVASIVE.COM