The NIDA CTN New England Consortium CTN New Englander Newsletter

Volume 4, Issue 4

IN THIS ISSUE

Study Updates

1

News from the

Field

Research News

2

Presentations

Publications

Upcoming

Meetings

3

Study Updates

CTN-0049 Hospital Visit as Opportunity for Prevention & Engagement for HIV-infected Drug Users (Project HOPE): The study continues to be conducted locally at Boston University Medical Center. Recruitment and enrollment is completed. The site enrol led 94 participants. Research data collect ion is ongoing. As of September 28, 2014, the site has continued to maintain a high rate of reten-tion at the 6-month and 12-month follow up time points (99% for month -6 and 100% for month-12).

CTN-0051 Extended Naltrexone vs. Buprenorphine for Opioid Treatment (X:BOT) : This study is taking place locally at Stanley Street Treatment and Resources, Inc. (SSTAR) in Fall River, Massachusetts. The site was endorsed to start recruit ing and enrol l ing study part icipants on May 30, 2014. As of September 30, 2014, 30 participants are randomized into the study, with 6 randomized in the month of September.

CTN-0053 Achieving Cannabis Cessation—Evaluating N-Acetylcysteine Treatment (ACCENT): This study being led by Kevin Gray, M.D., from the Southern Consort ium Node and the Medical University of South Carolina is taking place locally at The APT Foundation in Connecticut. The primary objective of this study is to evaluate the impact of N-Acetylcysteine (NAC) 1200 mg versus matched placebo (PBO) twice daily, added to contingency management (CM), on cannabis use among treatment-seeking cannabis-dependent adults. Team APT includes Dr. Kathleen Carroll (PI), Melissa Gordon (Project Manager), Stephanie Dwy (Research Coordinator), Skye Peters (Research Assistant), Drs. Julia Shi and Jeanette Tetrault (Study MDs), and Joanne Corvino (Recruiter). Enrol lment at APT began on February 10, 2014. As of Septem-ber 30, 2014, the site randomized 30 participants.

Fall 2014

Fall 2014

2

The New Englander

Substance Use Issues and Treatment in the Media

Substance use has been covered extensively in the print media this year. Here some titles of recent article titles from the Boston Globe from the summer.

A hard look at heroin: Maine recovery center uses art, poetry as a compelling reminder for addicts. July 20,

2014, pg. B1

A scourge in the seaside life: Deaths from heroin galvanize authorities, families in Scituate. July 28, 2014,

pg. A1

Priorities in addiction treatment bill debated: Some say inpatient stays are ineffective. July 29, 2014, pg. B1

Worcester sounds alarm over heroin. August 7, 2014, pg. A1

Overdose cases drop sharply in Taunton. August 7, 2014, pg. B1

Women get unequal treatment in court-ordered detox (Editorial). August 14, 2014, pg. A14

Losing Jamie: After a lifetime fighting alcohol and drug addiction-something our family’s devotion and means

were powerless to stop-my brother died of an overdose this spring. By George Bell. The Boston Globe

Magazine. August 24, 2014

Addicts wait for a lifesaver, column by Thomas Farragher, September 27, 2014, pg. B1

Recent Data from the SAMHSA National Survey on Drug Use & Health

On September 4, 2014, SAMHSA released a data report, “Substance Use & Mental Health estimates from the 2013 National Survey on Drug Use and Health: an Overview of Findings.” The report can be accessed through the SAM-HSA website,

http://samhsa.gov/data/2k14/NSDUH200/sr200-findings-overview-2014.htm

Survey shows lower rate of illicit drug use among adolescents

On September 16, 2014, SAMHSA released data from the National Survey on Drug Use and Health (NSDUH), show-

ing that illicit drug use was lower among adolescents aged 12 to 17 in 2013 (8.8 percent) than 2012 (9.5 percent) and

2002 (11.6 percent). SAMHSA’s NSDUH report also found that between 2002 and 2013, the level of youth aged 12

to 17 with substance dependence or abuse problems decreased from 8.9 percent to 5.2 percent.

http://www.samhsa.gov/newsroom/advisories/1409150311.aspx

3

The New Englander

PRESENTATIONS

Weiss, RD, Muchowski P, Hamilton J, Bailey G. “The National Drug Abuse Clinical Trials Network (CTN) in New England: Advancing Treatment Through a Partnership Between Researchers and Community Treatment Programs.” 2014 Cape Cod Symposium on Addictive Disorders, Hyannis, Massachusetts, September 13, 2014

Weiss, RD. Treatment of Prescription Opiate Dependence. Using Evidence-Based Practices in Community Set-tings: The NIDA/SAMHSA Blending Initiative a presentation sponsored by the New England Addiction Technol-ogy Transfer Center and the New England Consortium Node of the NIDA Clinical Trials Network, Marlborough, Massachusetts, September 18, 2014

Hamilton, J.The Role of the Provider in Developing Blending Products. Using Evidence-Based Practices in Community Settings: The NIDA/SAMHSA Blending Initiative a presentation sponsored by the New England Ad-diction Technology Transfer Center and the New England Consortium Node of the NIDA Clinical Trials Network, Marlborough, Massachusetts, September 18, 2014

PUBLICATIONS

Carroll KM. Lost in translation? Moving contingency management and cognitive behavioral therapy into clinical practice. Ann N Y Acad Sci. 2014 Sep 9. doi: 10.1111/nyas.12501. [Epub ahead of print]

Bogenschutz MP, Donovan DM, Mandler RN, Perl HI, Forcehimes AA, Crandall C, Lindblad R, Oden NL, Sharma G, Metsch L, Lyons MS, McCormack R, Konstantopoulos WM, Douaihy A. Brief Intervention for Patients With Problematic Drug Use Presenting in Emergency Departments: A Randomized Clinical Trial. JAMA Intern Med. 2014 Sep 1. doi: 10.1001/jamainternmed.2014.4052. [Epub ahead of print]

McHugh RK, Nielsen S, Weiss RD. Prescription drug abuse: from epidemiology to public policy. J Subst Abuse Treat. 2014 Aug 28. pii: S0740-5472(14)00187-1. doi: 10.1016/j.jsat.2014.08.004. [Epub ahead of print]

Potter JS, Dreifuss JA, Marino EN, Provost SE, Dodd DR, Rice LS, Fitzmaurice GM, Griffin ML, Weiss RD. The multi-site prescription opioid addiction treatment study: 18-month outcomes. J Subst Abuse Treat. 2014 Aug 2. pii: S0740-5472(14)00146-9. doi: 10.1016/j.jsat.2014.07.009. [Epub ahead of print]

McClure EA, Sonne SC, Winhusen T, Carroll KM, Ghitza UE, McRae-Clark AL, Matthews AG, Sharma G, Van Veldhuisen P, Vandrey RG, Levin FR, Weiss RD, Lindblad R, Allen C, Mooney LJ, Haynes L, Brigham GS, Sparenborg S, Hasson AL, Gray KM. Achieving Cannabis Cessation - Evaluating N-acetylcysteine Treatment (ACCENT): Design and implementation of a multi-site, randomized controlled study in the National Institute on Drug Abuse Clinical Trials Network. Contemp Clin Trials. 2014 Aug 30. pii: S1551-7144(14)00129-3. doi: 10.1016/j.cct.2014.08.011. [Epub ahead of print]

Hilario EY, Griffin ML, McHugh RK, McDermott KA, Connery HS, Fitzmaurice GM, Weiss RD. Denial of uri-nalysis-confirmed opioid use in prescription opioid dependence. J Subst Abuse Treat. 2014 Jul 18. pii: S0740-5472(14)00135-4. doi: 10.1016/j.jsat.2014.07.003. [Epub ahead of print]

Schuman-Olivier Z, Weiss RD, Hoeppner BB, Borodovsky J, Albanese MJ. Emerging adult age status predicts poor buprenorphine treatment retention. J Subst Abuse Treat. 2014 Sep;47(3):202-12. doi: 10.1016/j.jsat.2014.04.006. Epub 2014 May 20.

UPCOMING MEETINGS/CONFERENCES

Addiction Health Services Research Conference, Boston, Massachusetts, October 15-17, 2014 American Public Health Association, New Orleans, LA, November 15-19, 2014 American Academy of Addiction Psychiatry, Aventura, Florida, December 4-7, 2014