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The Next Generation of Health Care, Personalized Wellness and Prevention

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The Power of Knowing HistoryNow Scientific Breakthrough Shaman Palm Reader Tarot Card Reader HoroscopeHRA Personalized Genomics

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Have you ever wondered if you are at risk for any of these conditions?

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Finding out can bring peace of mind... I was floored when I read my Navigenics results which found that my highest elevated risk condition (96-98%) was colon cancer - I have just been diagnosed with colon cancer. Had I known my genetic risk years ago, I may have been more proactive and caught it even earlier. The cost is a small price to pay to prolong your life, especially if you have young kids or a family to provide for. -Sempra finance employee, Female, 51

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Finding out can bring peace of mind... Theres a condition that I have 16 times the risk of developing as compared to the general population: macular degeneration. When added to the fact this is the reason that my grandmother is currently going blind, Im suddenly a very motivated participant in my own health. While its a scary risk number, Im now positioned to have an impact on it, and Im incredibly happy that I know about it. -Microsoft program manager, Male, 30

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Finding out can bring peace of mind... For years, I experienced stomach problems that never went away. My sister encouraged me to get a Navigenics genetic test and my results showed I was at high risk of celiac disease. My doctor recommended I cut out gluten from my diet, and in the three weeks since I changed my eating habits, Ive lost eight pounds and my stomach problems have disappeared. -Urgent care employee, Female, 23

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Finding out can bring peace of mind... My analysis was mostly reassuring, but showed two areas of increased risk. One was celiac disease, which was a surprise. I followed up the Navigenics report with a serologic test and an upper endoscopy, which were positive for moderately severe celiac disease. It is amazing to me, at the age of 52 years, and being a physician, that my diagnosis and treatment was possible only because of your DNA test. -Head of oncology company, Male, 52

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The Navi Experience Your Storage at Fort Navi Your keyYouFort NavigenicsNavi key 04675 04676 04677 04678 04679 Your DNA

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We Plug Your Information Into a Database Your DNA Database + Insight Engine

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Help From Your Doctor and a Genetic Health Coach Your MDYour Genetic Counselor Your conditions with a high risk: Diabetes43% Breast Cancer 26% Alzheimers 12% Actions you can take: Early screening Early treatment Lifestyle change Right medications for you

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Navi Subscription Service Your DNA Insight Engine Alerts & updates about you Clinical trials pertinent to you Additional things of interest Your RisksMedical Information Consumer Knowledge Thinking About You 24 / 7

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The Value of What We Deliver You The best you can be + =

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Complexity of Business Sales Channel Access Regulation Consumer Engagement Physician Partnering Science Genetics Predictive Science Is a Barrier to Entry

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Employer Clients Unprecedented response rates averaging 27%

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Widespread consumer interest 91% of 1000 adults polled 55% of adults polled 4 out of 5 Americans Said they would have a genetic test for at least one disease condition Stated they would make health care decisions based upon genetic results Support nationwide genetic study

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Physician & Academic Partners

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Clinical Integration Demonstrated Methods to Engage MDs and Integrate Into Clinical Practice Only company to Reduce the complexity of preventive genomics into focused educational programs Integrate genetic counseling in service delivery Provide personalized tools to drive lifestyle changes based on genomics

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Navigenics services 28 health conditions 24/7 access to our Genetic Counselors Updates for one year DNA storage Pharmacogenomics will be introduced in early 2010 Health Compass

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Online summary genetic risk report Available within 2-4 weeks

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Questions?