The New Neurobiology of...
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Petros Levounis, MD, MA Professor and Chair, Department of Psychiatry Rutgers New Jersey Medical School Center of Excellence in Addiction Medicine Learning Collaborative Rutgers New Jersey Medical School Newark, New Jersey Monday, December 9, 2019 The New Neurobiology of Addiction
Transcript of The New Neurobiology of...
Petros Levounis, MD, MAProfessor and Chair, Department of Psychiatry
Rutgers New Jersey Medical School
Center of Excellence in Addiction Medicine Learning Collaborative
Rutgers New Jersey Medical School
Newark, New Jersey
Monday, December 9, 2019
The New Neurobiology of
Addiction
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1. The Basic Model
2. Neurobiology of Addiction
3. New Neurobiological Concepts
4. Addiction Treatments
5. New Directions
Outline
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1The Basic Model
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~ 1980
A Biopsychosocial Illness
Biological
Psychological
Social
Use Brain
Switch
Addiction
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Olsen and Levounis, Sober Siblings, 2008.
2Neurobiology of
Addiction6
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Food Sex
Box Feeding
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Female Present
Natural Rewards
Adapted from: Di Chiara et al, Neuroscience, 1999
Adapted from: Fiorino and Phillips, J Neuroscience, 1997
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COCAINE
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NICOTINE
Adapted from: Di Chiara and Imperato, Proceedings of the National Academy of Sciences USA, 1988; courtesy of
Nora D Volkow, MD
Effects of Drugs on Dopamine Levels
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0.51.02.510
Dose mg/kg
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Effects of Amphetamines on Dopamine Levels
AMPHETAMINE
Adapted from: Di Chiara and Imperato, Proceedings of the National Academy of Sciences USA, 1988; courtesy of
Nora D Volkow, MD.
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Pleasure-Reward Pathways
National Institute on Drug Abuse, www.nida.nih.gov, 2000.
3New Neurobiological
Concepts11
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2019
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Motivational Circuitry
Antireward Pathways
Interoception
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Three Novel Areas
Levounis, Journal of Medical Toxicology, 2016.
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Motivation: The Stinking Thinking Part
Reward and Antireward Systems
Gardner, Chronic Pain and Addiction, 2011.
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4Addiction
Treatments17
Medications
Motivational Interviewing
Mutual Help (12-step)
The Current Approach
Nunes, Selzer, Levounis, Davies, Substance Dependence and Co-Occurring Psychiatric Disorders, 2010.
Levounis, Arnaout, and Marienfeld, Motivational Interviewing for Clinical Practice, 2017.
Renner, Levounis, and LaRose, Office-Based Buprenorphine Treatment of Opioid Use Disorder, 2nd Ed., 2018.
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5New Directions
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“Between stimulus and response there is
a space. In that space is our power to
choose our response. In our response lie
our growth and our freedom.”
Viktor E. Frankl
4th Wave: Mindfullness
20Frankl V, Man’s Search for Meaning, 1959.
Zerbo, Schlechter, Desai, and Levounis, Becoming Mindful, 2017.
Thank you
NJMS.Rutgers.edu/Psychiatry
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