The Neuropathy Resident Tutorial 54
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Transcript of The Neuropathy Resident Tutorial 54
The Neuropathy ’54
Surat Tanprawate, MD, MSc(Lond.), FRCP(T)Division of NeurologyChiang Mai University
Med Res Tutorial for Board Exam
Tuesday, 31 May 2011
Tuesday, 31 May 2011
Tuesday, 31 May 2011
Brachial plexus
Lumbar plexusTuesday, 31 May 2011
Tuesday, 31 May 2011
Tuesday, 31 May 2011
History
Physical examination
(1) _ _ _ _ _ _ _
(2) associated finding
Investigation-EDX-Biopsy-Other lab
Final diagnosisPrognosisSeverity assessmentTreatmentF/U
Acute symmetrical predominant motor axonal
polyneuropathy
Tuesday, 31 May 2011
Step by step: polyneuropathy
1. Localization into the peripheral nervous system
2. To determine the anatomical pattern of the neuropathy
3. What is the primary pathology and fiber involved?
4. Predominated and associated neurological pattern
5. Temporal course of neuropathy
Tuesday, 31 May 2011
Tuesday, 31 May 2011
1. Localized into the LMN and nerve
Tuesday, 31 May 2011
Cranial Non-cranial
-Cranialmononeuropathy
-Multiple cranialneuropathy
Radiculopathy
Plexopathy
Neuronopathy
Peripheral -Mononeuropathy-Multifocal mononeuropathy-Polyneuropathy
MonoradiculopathyPolyradiculopathy
Motor neuronopathyGanglinopathy
Brachial plexopathyLumbosacral plexopathy
2. To determine the anatomical pattern of the neuropathy
Tuesday, 31 May 2011
4 limb <4 limb
Symm• Polyneuropathy• Polyradiculopathy
Asymm• Polyneuropathy• Polyradiculopathy• Multiple
mononeuropathy
1 limb>1 limb
Suspected entrapment neuropathy
• Asym.polyneuropathy
(polyradiculopathy)• Multiple mononeuropathy• Multiple nerve entrapment
Historical, Physical examination
Focal neuropathyTuesday, 31 May 2011
Classes of polyneuropathy according to which part of the nerve cell is mainly affected
Distal axonopathy, or "dying-back neuropathy
Myelinopathy, or "demyelinating polyneuropathy"
Neuronopathy
Metabolic or toxic disturbances-diabetes, renal failureDeficiency syndromes-malnutrition and alcoholismToxin or drugs-chemotherapy
Immune mediated neuropathy
Motor neuron disease, neuronopathies (HZV, chemotherapry)
Tuesday, 31 May 2011
• Distal
• toxic, metabolic (from dying back process)
• Proximal
• rare, include porphyria, GBS
• Lead neuropathy is an exception
• initially affects motor fibers in radial and peroneal distribution
When the distribution is symmetrical, is it proximal or distal
Tuesday, 31 May 2011
Predominated and associated neurological pattern
• Predominantly motor manifestations
• Neuropathies with facial nerve involvement
• Neuropathies with autonomic nervous system involvement
• Small-fiber neuropathies
• Sensory ataxic neuropathies
Tuesday, 31 May 2011
Predominantly motor symptom
• Multifocal motor neuropathy
• Guillain-Barre syndrome
• Acute motor axonal neuropathy
• Porphyric neuropathy
• Chronic inflammatory polyradiculopathy
• Neuropathy with osteosclerotic myeloma
• Diabetic lumbar radiculoplexopathy
• Hereditary motor sensory neuropatthies (Charcot-Marie-Tooth disease)
• Lead intoxication
Tuesday, 31 May 2011
Neuropathies with facial nerve involvement
• Guillain-Barre syndrome
• Lyme disease
• Sarcoidosis
• HIV-1 infection
• Gelsolin famillial amyloid neuropathy(Finnish)
• Tangier disease
Tuesday, 31 May 2011
Neuropathy with autonomic nervous system involvement
• Acute
• Acute dysautonomia
• Guillain-Barre syndrome
• Toxic: vincristine
• Chronic
• Diabetes neuropathy
• Amyloid neuropathy
• Paraneoplastic sensory neuropathy(malignant inflammatory sensory polyganglionopathy)
• HIV related autonomic neuropathy
• Hereditary sensory and autonomic neuropahty
Tuesday, 31 May 2011
Small fiber neuropathies
• Idiopathic small fiber neuropathy
• Diabetes mellitus and impaired glucose tolerance
• Amyloid neuropathy
• HIV associated distal sensory neuropathy
• Hereditary sensory and autonomic neuropathies
• Sjogren’s syndrome
Tuesday, 31 May 2011
Sensory ataxic neuropathy• Sensory neuropathies (polyganglinopathies)
• Paraneoplastic sensory neuronopathy
• Toxic polyneuropathies
• Cisplatin and analog
• Vitamin B6 excess
• Demyelinating polyradiculoneuropathies
• Guillain-Barre syndrome
• Immunoglobulin M monoclonal gammopathy of undetermined significance
Tuesday, 31 May 2011
3. What is the primary pathology and fiber involved?
• Primary pathology
• axonal, demyelination, mixed
• Nerve fiver involved
• sensory, motor, autonomic, mixed
• large fiber, small fiber
Tuesday, 31 May 2011
Clinical features suggesting axonal vs demyelination
• Axonal
• length-dependent neuropathy(dying back neuropathy)
• ascending extends proximally
• sensory loss in a stocking like pattern
• distal muscle weakness, and atrophy
• Demyelination
• relatively sparing of temperature and PPS
• early generalized loss of reflexes
• disproportionately mild muscle atrophy in the presence of proximal and distal weakness
• neuropathic tremor
• palpable enlarged nerve
Tuesday, 31 May 2011
When a nerve biopsy may be useful
• Inflammatory neuropathies
• Dysproteinaemic neuropathies
• Genetic neuropathies
• Metabolic disorders, with distinctive features and storage inclusions
• Tumour infiltration
• Toxic neuropathies, with characteristic changes, e.g. amiodarone, solvent abuse.
Practical Neurology, 2003, 3, 306–313
Tuesday, 31 May 2011
Enlargednerve
Michael Donaghy. Practical Neurology, 2003, 3, 40–45
-Leprosy-Hereditary motor and sensory neuropathy-Neurofibromatosis-Refsumʼs disease-Perineuroma/localized hypertrophic neuropathy-Nerve tumours-Amyloidosis
Tuesday, 31 May 2011
5. Temporal course of neuropathy
•The temporal course of a neuropathy varies, based on the etiology
Tuesday, 31 May 2011
DDx cause of neuropathy
Hereditary Acquire
• CMT
• Hereditary neuropathy with liability to pressure palsy
• Other
• Inflammatory demyelinating polyrediculoneuropathy
• Peripheral neuropathy associated with monoclonal protein
• Neuropathy associated with systemic disorder
• Diabetes, malignancy, connective tissue disease, alcohol and nutritional deficiency
• Toxic/drug neuropathy
Tuesday, 31 May 2011
Differential diagnosis of neuropathies by clinical course
Tuesday, 31 May 2011
Chronic progressive symmetrical sensorimotor axonal polyneuropathy with
family history
Tuesday, 31 May 2011
Inflammatory demyelinating neuropathies and related disorders
R. A. C. Hughes. J. Anat. (2002) 200, pp331–339Tuesday, 31 May 2011
Common drug induced neuropathy
AxonalVincristinePaclitaxel (Taxol)ColchicineIsoniazid HydralazineMetronidazole PyridoxineDidanosine LithiumAlfa interferon (Intron A)DapsonePhenytoin (Dilantin)CimetidineDisulfiramChloroquine Ethambutol Amitriptyline
DemyelinatingAmiodarone (Cordarone)ChloroquineSuramin Gold
Tuesday, 31 May 2011
Multiple mononeuropathy
• Multiple mononeuropathy is a asymmetric asynchronous sensory and motor peripheral neuropathy involving isolated damage to at least 2 separate nerve areas
• Disease: DM, vasculitis, amyloidosis, direct tumor involvement, PAN, RA, SLE, paraneoplastic syndrome
Tuesday, 31 May 2011
Neuropathy of Diabetes
Tuesday, 31 May 2011
Definition
Diabetic neuropathy is defined as
“The presence of symptoms and signs of peripheral nerve dysfunction in individuals with diabetes after the exclusion of other causes.”
CIDP, vitamin B12 deficiency, alcoholic neuropathy, endocrine neuropathy
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The risk of developing symptomatic neuropathy in patients without neuropathic symptoms or signs at the time of initial diagnosis of diabetes is estimated to be
“4% to 10% by 5 years”
“50% by 25 years”
Tuesday, 31 May 2011
Classification of Diabetes Neuropathies
Symmetrical polyneuropathies - Distal sensory or sensorimotor polyneuropathy (DSDP) - Small-fiber neuropathy - Autonomic diabetic neuropathy(DAN) - Large-fiber neuropathy
Asymmetrical neuropathies - Cranial neuropathies (single or multiple) - Truncal neuropathy (thoracic radiculopathy) - Limb mononeuropathy (single or multiple) - Lumbosacral radiculoplexopathy (asymmetrical proximal motor neuropathy) - Focal limb neuropathies (including compression and entrapment neuropathy)
Combinations - Polyradiculoneuropathy - Diabetic neuropathic cachexia - Symmetrical polyneuropathies
Tuesday, 31 May 2011
Classification of Diabetes Neuropathies
Symmetrical polyneuropathies - Distal sensory or sensorimotor polyneuropathy (DSDP) - Small-fiber neuropathy - Autonomic diabetic neuropathy(DAN) - Large-fiber neuropathy
Asymmetrical neuropathies - Cranial neuropathies (single or multiple) - Truncal neuropathy (thoracic radiculopathy) - Limb mononeuropathy (single or multiple) - Lumbosacral radiculoplexopathy (asymmetrical proximal motor neuropathy) - Focal limb neuropathies (including compression and entrapment neuropathy)
Combinations - Polyradiculoneuropathy - Diabetic neuropathic cachexia - Symmetrical polyneuropathies
3/4 of all
Tuesday, 31 May 2011
Clinical Pattern of Diabetic neuropathy
Tuesday, 31 May 2011
Distal Symmetrical Polyneuropathy
• Most common
• Clinical features:
• sensory deficit predominate
• autonomic symptoms correlated with severity
• minor motor symptom affecting the distal lower extremity muscles
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Sub-classification
Tuesday, 31 May 2011
Sub-classification
Pure small fiber
Pure large fiber
Tuesday, 31 May 2011
Sub-classification
Pure small fiber
Pure large fiber
-pain of a deep, burning , stinging, aching character, allodynia to light touch-accompanied by autonomic neuropathy-impaired pain and temp, but relatively spared joint position, vibration and muscle stretch reflex
Tuesday, 31 May 2011
Sub-classification
Pure small fiber
Pure large fiber
-pain of a deep, burning , stinging, aching character, allodynia to light touch-accompanied by autonomic neuropathy-impaired pain and temp, but relatively spared joint position, vibration and muscle stretch reflex
-painless paresthesia beginning at toes and feet-impairment of vibration and joint position sense-diminish muscle stretch reflex-often asymmetric-sensory ataxia (advance case)
Tuesday, 31 May 2011
Complication of distal symmetrical sensory
polyneuropathy
• Charcot’s joint
• Painless trauma and burn
• Trophic change and plantar ulcer
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Charcot’s joint(Neuropathic osteoarthropathies)
• 1868: Jean-Martin Charcot described of the neuropathic aspect of arthralgia as a complication of syphilis
• 1936: Jordan linked neuropathic joint to diabetes which is the most common etiology now
Tuesday, 31 May 2011
Charcot’s jointPicture from Br J Sports Med 2003;37:30–35
Joint dislocation, pathologic fractures and debilitating deformities
Lateral radiograph of a patient with diabetes with Charcot foot disease. Notice the midfoot collapse, leaving the patient with an inverted arch
Picture from www.Medscape.com
Tuesday, 31 May 2011
Foot ulceration
•the lifetime incidence maybe as high as 25%•50-70% of all non-traumatic lower extremity amputations can be attributed to diabetes
Tuesday, 31 May 2011
Clinical assessment in diabetic symmetrical polyneuropathy (DSDP)
• Look for any deformity, callus or foot ulcer, infection or fissure
• Absent ankle reflexed
• Test all sensory modalities: vibration, neurofilament test
• Weakness of small foot muscles (EHL, EDB)
• Check resting pulse and BP lying and standing
• Check peripheral pulses
Tuesday, 31 May 2011
Diabetic Neuropathy Diagnosis
• The diagnosis of peripheral neuropathy can be made only after a careful clinical examination with more than 1 test (the American Diabetes Association recommendation)
• Vibration perception (using a 128-Hz tuning fork)
• pressure sensation (using a 10-g monofilament at least at the distal halluces)
• ankle reflexes
• pinprick
Tuesday, 31 May 2011
Symptomatic autonomic neuropathy• although symptomatic autonomic
neuropathy is relatively uncommon, but specific autonomic function tests show abnormality in 97% of DSDP patients
• If there is a prominent autonomic neuropathy in diabetic with no or mild DSDP, think of another cause of autonomic disturbance
Llewelyn JG. JNNP 2003;74(Suppl II):ii15–ii1
Tuesday, 31 May 2011
What atypical features might suggest an alternative neuropathy?
1. Severe autonomic neuropathy with mild DSDP
• Amyloid neuropathy
2. Rapidly progressive motor component
• Chronic inflammatory demyelinating polyneuropathy (CIDP)
Llewelyn JG. JNNP 2003;74(Suppl II):ii15–ii1
Tuesday, 31 May 2011
Classification of Diabetes Neuropathies
Symmetrical polyneuropathies - Distal sensory or sensorimotor polyneuropathy (DSDP) - Small-fiber neuropathy - Autonomic neuropathy - Large-fiber neuropathy
Asymmetrical neuropathies - Cranial neuropathies (single or multiple) - Truncal neuropathy (thoracic radiculopathy) - Limb mononeuropathy (single or multiple) - Lumbosacral radiculoplexopathy (asymmetrical proximal motor neuropathy) - Focal limb neuropathies (including compression and entrapment neuropathy)
Combinations - Polyradiculoneuropathy - Diabetic neuropathic cachexia - Symmetrical polyneuropathies
Tuesday, 31 May 2011
Clinical scenario
“A middle age diabetic patients develop severe aching or burning and lancinating pain in the hip and thigh. This is followed by weakness and wasting of the thigh muscles, which occur asymmetrically.”
“Diabetic amyotrophy”
Tuesday, 31 May 2011
Diabetic lumbosacral radiculoplexus neuropathy (Brun-Garland syndrome)
• Bruns described the syndrome in 1890, and Garland rediscovered and coined the term “amyotrophy”
• Common in older patients with type 2 DM
• Clinical feature and evolution are variable
“Diabetic amyotrophy”
Tuesday, 31 May 2011
Clinical Pattern of Diabetic neuropathy
Tuesday, 31 May 2011
DCCT: Result Summary
Improved control of blood glucose reduces the risk of clinically meaningful
• Retinopathy 76% (P<0.002)
• Nephropathy 54% (P<0.04)
• Neuropathy 60% (P<0.002)
DCCT Research Group. N Eng J Med. 1993;329:977-986.
DCCT: risk of DPN and DAN are reduced with improved blood glucose control(DM type 1 and 2)
Tuesday, 31 May 2011
Entrapment neuropathy
Tuesday, 31 May 2011
Entrapment neuropathy
• To remember
• Remember as the a muscle group (set)
• Remember: actions, muscles, roots, nerves
• Understand terms and pathways of innervation
• Approaching process of “drop” symptoms
• Clinical skill practice
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Tuesday, 31 May 2011
Muscle groups
Upper extremities
Lower extremities
Proximal
Distal
•Shoulders
•Abduction
•Elbows
•Flexion, Extension
•Wrists
•Extension, Flexion
•Fingers
•Extension, Flexion
•Abduction
Proximal
Distal
•Hips
•Flex, Extend, Adduct, Abduct
•Knee
•Flexion, Extension
•Ankles
•Dorsiflexion, Eversion, Inversion, Plantar flexion
•Toes
•Great toe dorsiflexion
Tuesday, 31 May 2011
Musculocutaneous nerve
Axillary nerve
•Pass under axillar•Muscle: deltoid
Nerve innervate only proximal muscle group
•Muscle: bicep•Cutaneous: lateral cutaneous nerve of forearm
Tuesday, 31 May 2011
Radial nerve
• Radial nerve:
• run around radial groove
• Form:
• Posterior interosseous n.
• Superficial radial n.
Nerve innervate extensor muscle group
Tuesday, 31 May 2011
Radial nerve
• Radial nerve:
• run around radial groove
• Form:
• Posterior interosseous n.
• Superficial radial n.
Tricep
Brachioradialis
Extensor carpiradialis
Extensor digitorum
pollicis indices
Tuesday, 31 May 2011
Median nerve
• Median nerve:
• run medial part of arm
• Form:
• Median n.
• Anterior interosseous n.
Nerve innervate distal muscle group
Tuesday, 31 May 2011
Median nerve
• Median nerve:
• run medial part of arm
• Form:
• Median n.
• Anterior interosseous n.
Flexor carpi radialis
Flexor digitorum superficialis
Flexor digitorum profundus 1 & 2
Pollicis longus
LOAF muscle group
Tuesday, 31 May 2011
Ulnar nerve
• Ulnar nerve:
• run ulnar side of the arm
• Innervate:
• Most intrinsic hand muscle, except LOAF muscle group
Nerve innervate distal muscle group
Tuesday, 31 May 2011
Ulnar nerve
Flexor carpi ulnaris
Flexor digitorum profundus 3 & 4
Intrinsic hand muscle except
LOAF
• Ulnar nerve:
• run ulnar side of the arm
• Innervate:
• Most intrinsic hand muscle, except LOAF muscle group
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Tuesday, 31 May 2011
Obturator nerve-adductor group
Femoral nerve-quadricep femoris
Superior gluteal nerve
-gluteus medius-gluteus minimus
Tuesday, 31 May 2011
Sciatic nerve
Tibial nerve-Gastrocnemius-Tibialis posterior
Common peroneal nerve
-Deep peroneal nerveTibialis anteriorExtensor pollicis longus
-Superficial peroneal nerve
Peroneus longusPeroneus brevis
Tuesday, 31 May 2011
Physical examination
• Action>>Muscle>>Roots>>Nerve
• Remember group by group
• Need to know the basic knowledge of nerve innervation into the muscle
Tuesday, 31 May 2011
shoulder abduction deltoid C5,6 axillary n.
elbow flex biceps C5,6 musculocutaneus n.
elbow flex brachioradialis C5,6 radial n.
elbow extension triceps C7,8 radial n.
wrist flex FCR C6,7 median n.
wrist extension ECR longus C5, C6 radial n.
finger extension Ext. Digitorum communis C7 PIN
finger flex FPL+FDP(index)FDP(ring+little)
C8C8
AINUlnar
finger abduction 1 DIAPB
T1T1
UlnarMedian
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Tuesday, 31 May 2011
Tuesday, 31 May 2011
Hip flex Iliopsoas L1, 2 Femoral n.
Hip adduct Adductor L2, 3 Obturator n.
Hip Abduct Gluteus medius, minimus
L4, 5 Superior gluteal n.
Hip extension Gluteus maximus L5, S1 Sciatic n.
Knee extension Quadricep L3, 4 Femoral n.
Knee flexion Hamstring L5, S1 Sciatic n.
Ankle dorsiflex TA L4, 5 DPN
Ankle eversion Peronei L5, S1 SPN
Ankle inversion TP L4, 5 Tibial n.
Plantar flexion Gastrocnemius S1, S2 Tibial n.
Big toe extension EHL L5 DPN
Tuesday, 31 May 2011
Approaching process
1. What’s action and muscle causing “drop”
2. What’s root and nerve innervated that “weak” muscle
3. To test key muscles !
-Same root, but different nerve
-Same nerve, but different root
4. Evaluated sensory loss
5. Give a diagnosis
Aim: identify site of lesion:root, plexus, nerve
(awareness the UMN: pyramidal weakness)
Tuesday, 31 May 2011
Entrapment of upper extremi/es
• Clinical approach–Proximal arm weakness
–Wrist drop
–Hand atrophy
Tuesday, 31 May 2011
Proximal arm weakness
• Proximal arm muscle: key muscle–Deltoid:C5,6‐ axillary n.–Bicep: C5, 6‐ musculocutaneous n.
–Tricep: C7,8‐ radial n.–Brachioradialis: C5, 6‐ radial n.
• PaGern involved–Deltoid alone
• axillary n. lesion
–Deltoid, bicep, brachioradialis involved(spare tricep)• C5,6 root
– Involve alls muscle• Brachial plexus• Cord
Tuesday, 31 May 2011
Wrist drop
• Wrist drop–Extexsor carpi radialis longus(C5, C6 and radial nerve)
–Extensor carpi ulnarlis( C7, C8 and posterior interosseous branch of radial nerve)
Tuesday, 31 May 2011
Key muscle: nerve, root
• Key muscle: radial distribu/on–Radial n: tricep, brachioradialis
–P.I.N: extensor digitorum, extensor carpi ulnaris
• Key muscle: C5,6–Deltoid: axiallary n–Bicep: musculocutaneous n.
–Tricep: radial n.(C6,7,8)–FCR: median n.(C6,7)
Tuesday, 31 May 2011
Interpret
• Generalized weakness: esp. weakness of deltoid, tricep, wrist ext, finger ext.– UMN: cor/cospinal tract lesion
• Selected weakness–C7,C8 root or plexus–Radial nerve lesion–Posterior interosseous nerve lesion
Tuesday, 31 May 2011
Out stretch arm test
Tuesday, 31 May 2011
Tricep Brachioradialis Wrist extension
Finger extension
Finger flexion
PIN lesion
(finger drop with radial devia/on)
Normal Normal Normal (radial
divia/on)
Weak Normal
C7,8 or brachial
plexus lesion
Weak Normal Radial divia/on
Weak Weak
Radial nerve lesion(radial groove)
(wrist drop)
Normal Weak Weak Weak Normal
C5,6 or
Brachial plexus
Weak Weak Weak Normal Normal
Tuesday, 31 May 2011
Tuesday, 31 May 2011
• Muscle of hand–LOAF(median n.), other than LOAF(ulnar n.)
–Key muscle: 3 muscle• APB(for LOAF), ADM and 1 DI(for other than LOAF)
• Root innerva/on–APB: C8 T1–1DI: C8, T1–ADM: C8, T1
• PaGern of weakness–Only APB: median n. lesion‐test other flexor m. group
–Only ADM and 1DI: ulnar n. lesion
–Weak all 3 muscle: many causes
Tuesday, 31 May 2011
• 3 muscle plus finger extensor, tricep, finger flexor–C7,8,T1 root
• Fail arm+ all sensa/on–Brachial plexus
• Fail arm and cape distribu/on sensory loss–Spinal cord
• Generalized–MND–Polyneuropathy
Tuesday, 31 May 2011
Tuesday, 31 May 2011
Lower extremi/es
• Lumbosacral plexus
• Proximal–Anterior: obturator n., femoral n.
–Posterior: gluteal n., scia/c n(hamstring m.)
• Distal –Anterior: peroneal nerve(deep VS superficial)–Posterior: /bial nerve
Tuesday, 31 May 2011
Proximal weakness of legs
• Key muscle– Iliopsoas m: L1, 2‐ femoral n.
–Quadricep m: L2,3‐ femoral n.
–Adductor m: L3,4‐ obturator n.
–Hamstring m: L5, S1,2‐ scia/c n.
–Gluteus maximus m: L5, S1,2‐ inferior gluteal n
• Weak • Iliopsoas+quadricep
–Femoral n. lesion
• Iliopsoas+quadricep+ hip adduc/on–L2,3, 4 lesion
Tuesday, 31 May 2011
Foot drop
• Due to weakness of /bialis anterior• Key muscle
–Tibialis anterior m: L4,5‐DPN
–EHL: L5, S1‐ DPN–Peroneus m: L5, S1‐ SPN
–Tibialis posterior m: L4,5 ‐ /bial n.
–Gastrocnemius m: S1,2 ‐ /bial n.
Tuesday, 31 May 2011
PaGern of foot drop
• weakness of
• Dorsiflex+eversion+EHL–Common peroneal n. lesion
• Dorsiflex+inversion+ hip abduc/on–L4, 5 root or plexus lesion
• Alls movement of foot–Peripheral neuropathy–Scia/c n. lesion–Plexus lesion–Cauda equina lesion–Anterior horn cell disease
Tuesday, 31 May 2011
Differen/al diagnosis of foot drop
Tuesday, 31 May 2011
Tremor short case
1. Identify tremor type
2.Test associated neurological signs and general physical signs
Tuesday, 31 May 2011
Tremor type: 3 position
Tuesday, 31 May 2011
Tremor at rest
• Test sign of parkinsonism
• Bradykinesia: finger tapping, writing (micrographia), walking
• Cogwheel rigidity: muscle tone of arm
• Postural instability
• associated signs: Gabellar tapping
Tuesday, 31 May 2011
Tremor at postural position-2 ท่า
• Thyroid palpation
• pulse rate
• Look lid lag, lid retraction
• Hair
• Skin
• reflexes
Tuesday, 31 May 2011
Kinetic tremor (esp.intention tremor)
• Check other sign of cerebellar dysfunction
• eye movement
• listen to voice(for dysarthria)
• rapid alternating movement
• heel knee chin
• gait, and tandem walk
• Other neuro sign ถ้าเวลาเหลือ
Tuesday, 31 May 2011