The Life Course Perspective: CuttingEdge Science for Urban MCH Michael C. Lu, MD, MPH Assistant...
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![Page 1: The Life Course Perspective: CuttingEdge Science for Urban MCH Michael C. Lu, MD, MPH Assistant Professor Department of Obstetrics & Gynecology David Geffen.](https://reader035.fdocuments.net/reader035/viewer/2022062718/56649e865503460f94b89e94/html5/thumbnails/1.jpg)
The Life Course Perspective:CuttingEdge Science for Urban MCH
Michael C. Lu, MD, MPHAssistant Professor
Department of Obstetrics & GynecologyDavid Geffen School of Medicine at UCLA
Department of Community Health SciencesUCLA School of Public Health
![Page 2: The Life Course Perspective: CuttingEdge Science for Urban MCH Michael C. Lu, MD, MPH Assistant Professor Department of Obstetrics & Gynecology David Geffen.](https://reader035.fdocuments.net/reader035/viewer/2022062718/56649e865503460f94b89e94/html5/thumbnails/2.jpg)
Life Course Perspective
Pregnancy
Reproductive Potential
Age
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Life Course Perspective
Pregnancy
White
AfricanAmerican
Reproductive Potential
Age
![Page 4: The Life Course Perspective: CuttingEdge Science for Urban MCH Michael C. Lu, MD, MPH Assistant Professor Department of Obstetrics & Gynecology David Geffen.](https://reader035.fdocuments.net/reader035/viewer/2022062718/56649e865503460f94b89e94/html5/thumbnails/4.jpg)
Life Course Perspective
Early programming Cumulative pathways
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Early Programming
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Barker HypothesisBirth Weight and Coronary Heart Disease
0
0.25
0.5
0.75
1
1.25
1.5
<5.0 5.0-5.5 5.6-7.0 7.1-8.5 8.6-10.0 >10.0
Birthweight (lbs)
Age Adjusted Relative Risk
Rich-Edwards 1997
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Barker HypothesisBirth Weight and Hypertension
155
160
165
170
Syst
olic
Pre
ssur
e (m
mH
g)
<=5.5 5.6-6.5 6.6-7.5 7.6-8.5 >8.5
Birthweight (lbs) Law 1993
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Barker HypothesisBirth Weight and Insulin Resistance Syndrome
0
2
4
6
8
10
12
14
16
18
<5.5 5.6-6.5 6.6-7.5 7.6-8.5 8.6-9.5 >9.5
Birthweight (lbs)
Odds ratio adjusted for BMI
Barker 1993
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Prenatal Period is a “Sensitive” or “Critical” Period
Health or Function
Birth
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Welberg LAM, Seckl JR. Prenatal stress, glucocorticoids and the programming of the brain.J Neuroendocrinol 2001;13:113-28.
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Scientific American 2003
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Epigenetics
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Cumulative Pathways
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Allostasis
McEwen 1998
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AllostasisMcEwen 1998
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Stress and Allostastic LoadMcEwen 1998
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AllostasisChikanza 2000
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Life Course Perspective
Pregnancy
White
AfricanAmerican
Reproductive Potential
Age
![Page 21: The Life Course Perspective: CuttingEdge Science for Urban MCH Michael C. Lu, MD, MPH Assistant Professor Department of Obstetrics & Gynecology David Geffen.](https://reader035.fdocuments.net/reader035/viewer/2022062718/56649e865503460f94b89e94/html5/thumbnails/21.jpg)
Life Course Perspective
Prenatal Care
Poor Birth Outcome
0 5 PregnancyPuberty
Internatal Care
Primary Care for Women
Early Intervention
Prenatal Care
Primary Care for Children
Age
White
AfricanAmerican
Lu 2003
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Closing Black-White Gap in Birth OutcomesA Life-Course Approach
1. Provide interconception care to women with prior adverse pregnancy outcomes
2. Increase access to preconception care to Black women 3. Improve the quality of prenatal care 4. Expand healthcare access over the life course 5. Restore Black fathers to Black families 6. Enhance coordination and integration of family support
services 7. Create reproductive social capital in Black communities 8. Invest in community building and urban renewal 9. Close the education gap 10. Reduce poverty among Black families 11. Support working mothers and families 12. Undo racism
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Prenatal Programming
How to make a smart and healthy baby for life?
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Prenatal Programming
Brain development Immune development Metabolic development
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Prenatal Programming
Is there prenatal programming of school readiness?
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Prenatal Programming
Is there prenatal programming of obesity?