The universe of molecules... The world of KONIK

THE KONIK GROUP

KONIXBERT HI-TECH S.A. (KONIK-TECH)

2 KONIK GROUP PROFILE

2004

2007

Doctor Josep M. Gibert, President of the KONIK GROUPDr. Josep M. Gibert, KONIK Group founder and current President and CEO, has a life long experience in GC, HPLC, and MS. Since his early work with professors Joan Juli Bonet and Miguel Gassiot at the Sarrià Chemical Institute of the Ramon Llull University (Steroids in cat urine by Gas Chromatography, Degree Thesis 1967), to his Ph.D. at the University of Houston (Gas Chromatographic-Mass Spectrometric Determination of Organic and Organogenic matter in Lunar samples, Carbonaceous Chondrites, and Terrestrial samples, 1971) under the advice of Professors Joan Oró and Albert Zlatkis. A Google search of three words: Gibert Apollo Murchison, provides a background of Dr. Gibert’s pioneering work in GC-MS determination, and trace analysis, of a wide number of compounds in many valuable sample matrixes such as Lunar samples. Upon his return from the U.S. in 1973 Josep M. Gibert was Associate Professor of Analytical Chemistry at the Autonomous University of Barcelona and at the Institute of Fundamental Biology (IBF) currently IBB until 1977 when he started the KONIK Group to contribute to the continuous innovation, development and diffusion of these powerful analytical techniques.

A company driven by excellence over 30 years with the second generation in place

KONIK, a group driven by excelence. KONIK has been awarded the three most prestigious awards by the associated Chamber of Commerce and Industry (Terrassa, Barcelona):

2004. Internacionalization2007. Innovation2009. Corporate Social Responsability

2009

KONIK HISTORICAL TRACK RECORD OF PIONEERING

INNOVATIONS AND TECHNOLOGICAL BREAKTHROUGHS... 1978 WORLD’S FIRST PURPOSELY DESIGNED GC FOR CAPILLARY COLUMNS

1985 WORLD’S “STATE-OF-THE-ART” FIRST ISOKINETIC LOW PRESSURE GRADIENT MIXING HPLC WITH BUILT IN OVEN AND COLUMN/DETECTOR SWITCHING

1989 WORLD’S FIRST TIGHT/SEPTUM PURGE-FREE CAPILLARY INJECTOR FOR GC

1993 WORLD’S FIRST LOW INERTIA FAST HEATING/COOLING GC OVEN

1997 WORLD’S FIRST MULTIMODAL ROBOTICS: KONIK ROBOKROM FOR P&T, HS, SPµE, TD, GC AS, HPLC AS... ALL IN ONE

2002 PROTOTYPE OF FIRST DIGITAL MULTIMODAL QUAD MS

2004 WORLD’S FIRST REMOTE CONTROL FULLY DIGITAL, QUADRUPOLE GC-MS

2005 WORLD’S FIRST PATENT OF THE TOTAD HPLC+GC/ MULTIDIMENSIONAL COUPLING INTERFACE

2006 WORLD’S FIRST PATENTED MULTIDIMENSIONAL HPLC+GC AND HPLC+GC-MS

2007 WORLD’S FIRST VARIABLE ANGLE ESI/APCI ION SOURCE FOR HPLC-MS

2010 WORLD’S NEW STATE-OF-THE-ART KONIK GC 5000 B, HPLC 600 AND MS Q12 PURPOSELY DESIGNED FOR GROWTH TO MULTIDIMENSIONAL HPLC+GC, AND HPLC+GC-MS

2010 WORLD’S FIRST KONIK DERIVATIZER®, AN ON-LINE DERIVATIZATION SYSTEM FOR POLAR COMPOUNDS

2010 WORLD’S FIRST PATENTED KONIK “QUANTITATOR®” ABSOLUTE/UNIVERSAL QUANTIFICATION SYSTEM

2011 WORLD’S FIRST KONIK PATENTED KLINILYZER, FOR EARLY DETECTION OF METASTASIS OF CANCER. THE FIRST PRODUCT OF KONIK DIAGNOSTIKA

2011 KONIK ENGINEERING IS STRUCTURED FOR TURN-KEY PROJECTS TECHNOLOGY TRANSFER AND OEM AGREEMENTS

FOCUSSED TO DEVELOP MULTIDIMENSIONAL HPLC+GC-MS!

4 KONIK GROUP PROFILE

KONIK GC, GC-MS, HPLC AND HPLC-MS OFFER UNMATCHED SPECIFICATIONS

MODULE BY MODULESYSTEM BY SYSTEM...BUILD UP YOUR DREAM!

ROBOKROMAUTOSAMPLER & AUTOINJECTORP&T, HS, SPµE, TD, GC AS, HPLC AS...

ROBOKROMAUTOSAMPLER & AUTOINJECTORP&T, HS, SPµE, TD, GC AS, HPLC AS...

GC 5000BGC 5000B

GC-MS MSQ12

5000B GC

GC-MS MSQ12

5000B GC

MODULE BY MODULESYSTEM BY SYSTEM...BUILD UP YOUR DREAM!

KONIK GC, GC-MS, HPLC AND HPLC-MS OFFER UNMATCHED SPECIFICATIONS

HPLC+GC-MS IS THE NEXT STEP TO TANDEM MS-MS!

ON THE WAY TO CELEBRATE THE 35th ANNIVERSARY

IN 2013

ON THE WAY TO CELEBRATE THE 35th ANNIVERSARY

IN 2013

HPLC-MS & HPLC 600HPLC-MS & HPLC 600

K2Q12MULTIDIMENSIONAL HPLC+GC-MS

K2Q12MULTIDIMENSIONAL HPLC+GC-MS

QUANTITATOR

UNIVERSALQUALI/QUANTIOF ANYCOMPOUND

TARGET ANALITES

EI/CI/CID

ON-LINEDERIVATIZATION

CONCENTRATIONINTERFACE

HPLC CLEAN-UPAND/OR UNLIMITED

FRACTIONATION

HPLC+GC-MS IS THE NEXT STEP TO TANDEM MS-MS!

6 KONIK GROUP PROFILE

KONIK GC 5000 B· Oven +/- 0.1ºC / Tight injector / Digital pneumatics· Maximum productivity gas saving· Cold septum purge free tight injector: guarantees sample integrity from low boilers to high boilers · Ultra-fast Chromatography. High precision oven and low thermal inertia · Highest accuracy digital pneumatics

KONIK HPLC 600· Up to 6 solvents gradient/selection (3x2)· Unmatched gradient reproducibility· Total automation· Column /detector switching, Column backflushing· Complete line in HPLC: Isocratic, Gradient, Biocompatible, Ion Chromatography...

KONIK K2Q12 Multidimensional HPLC+GC-MS · Coupling in synergy of two chromatographic techniques: HPLC to GC and to GC MS· Innovative and patented technology· The KONIK K2 HPLC+GC-MS is a powerful tool to develop innovative analytical methodologies, simplifying or eliminating sample preparation. Thanks to its enrichment step, can easily reach lower detection limits in complex matrices· Simplify or eliminate sample preparation· Save solvents and time reduced costs· Lower detection limits· Push the limits of total qualitative and quantitative of any compound in any sample

KONIK Molecular Analyzers Line

KONIK Elemental and Spectroscopic AnalyzersAtomic Absorption UV Visible Spectrophometer Flame Photometer

· Temperature from 25ºC to 490ºC in 0.1ºC steps · 0.1ºC accuracy displayed· All injection options available for any kind of column · Complete range of detectors, MS included· All multivalve, turn-key purposelly ingeniering options· Designed for HPLC+GC and HPLC+GC-MS couplings · Full remote control

· UV-Vis detectors, PDA, Fluorescence, Refractive index, Conductivity, Electrochemical, MS, EVLSD...· Column oven with temperature programming· The best solution for your laboratory with the best quality/price relationship· Designed for Multidimensional HPLC+GC-MS

KONIK MS Q12®/GC-MS/HPLC-MS· Maximum versatility· Dual Ionization source EI and CI for positive and negative ions and ESI/APCI for HPLC-MS· Vacuum sealed photomultiplier detector guaranteed operation for at least 10 years· Differential vacuum system between source and analyzer, 2 turbomolecular pumps, 200 1/s each flow, low noise, low rotation speed (only 36.000rpm) and air cooled optimal for H2 pumping

· Manual and automatic tuning · Total control with Konikrom MS Plus® Windows®-based environment· Direct Insertion Probe (DIP) and Direct Exposure Probe (DEP) Option· Total remote control from Internet for processing, transfer, import/export data, technical support, tuning and calibration instruments, sharing of methods between laboratories...· Absolute/Total Quantitation option for GC-MS

The most powerful, unmatched, analytical platform for virtually universal quali-quanti of target and unknown organics in any sample!!!

·Environment: Target and emerging pollutants in air, water sediments... for EPA like and other innovative methods·Food: Pesticide residues, contaminants, food integrity, nutritional constituents and biomarkers, additives, adulterants...·Chemicals: EC REACH directive, toxicology... improved standard methods·Pharma: Bioequivalence assays, Bioassays, Biomarkers, Pharmacokinetics, Pharmacopeia methods... ·Life sciences and clinical chemistry: Metabolomics, molecular medicine, early diagnosis of many diseases...·Toxicology and sports medicine: antidoping controls, criminal toxicology and forensics, drugs of abuse...·Petroleum and derivatives: ASTM; UOP... Characterization, fingerprinting, catalysis, bio fuels, biomass conversion...·R&D: Determine any target, as well as any unknown analytes, in any sample at lower detection limits, with simplified or not sample preparation at all...

The new patented alternative, complementary platform, to HPLC-MS-MS and GC-MS-MS!!! With lower investment, operational cost, simpli�ed sample prep, user friendly with direct library search... and guaranteed lowest cost per analysis offering also absolute and universal quantitation using only one internal reference standard the Konik Quantitator!

CHROMATOGRAPHY & MASS SPECTROMETRY A NEW WORLD OF APPLICATIONS PROJECTED WORLDWIDE

KONIK CUSTOMERS AND MARKETS

SOME CUSTOMER REFERENCES

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KONIXBERT HI-TECH S.A (KONIK-TECH)

The universe of molecules... The world of KONIK

Headquarters:

EUROPE, Barcelona:T (+34) 93 590 28 40F (+34) 93 590 28 44

Av. Cerdanyola, 7308172 Sant Cugat, Barcelona, Spain

For more information on our products and services, please visit our website at: www.konik-group.com

Or contact:Sales: sales@konik-group.comTech Service: sat@konik-group.comLab: applications.lab@konik-group.com

USA, Miami:T (+1) 305 252 05 06F (+1) 305 252 08 09

12221 SW, 129th Ct.Miami, Florida 33186, USA

KONIK Marketing Regional offices at:argentina@konik-group.comkcaribe@enet.cumadrid@konik-group.commiami@konik-group.com

Opening soon:mumbai@konik-group.combeijing@konik-group.com

KONIK-TECH is an ISO 9001 Certified Company

Design, manufacturing and commercialization of analytical instruments, laboratory equipment, consumables and accessories.

With the support of:

Growth as reported at

“ENTREPRENEURS” April 2011

(Emprendedores)2006

2007

2008

2009

2010

European Regional Development Fund“A new way to construct europe”

A GROUP OF COMPANIES FOCALIZED IN COMPLEMENTARY ACTIVITIES

Konik-Tech· Gas Chromatography· HPLC· GC-MS & HPLC-MS· HPLC+GC & Multidimensional HPLC+GC-MS K2Q12· New consumables, Accesories Catalogue and Spares

Engineering· OEM & Technology transfer agreements · Turn key engineering projects· Energy. Processes optimization

Diagnostika· Earlier detection of metastasis of certain cancer, metabolic disordes, degenerative diseases and infections· Nutritional biomarkers· Preventive molecular medicine

Nanobiotech· Surface science Nanotechnology systems: ICP-CVD, PVD, PECVD, RIE, ALD, HVPE, IBD, IBE, nanoscale growth· Vacuum and ultra-high vacuum components: Pumps, chambers, feedthroughs (electrical, heat, motion and manipulation), gauges, leak detectors, valves, flanges, fittings and targets· Biotech products, tools & systems

Ikai· Specialized analytical services and clinical diagnostics· Bioequivalence assays and pharmacokinetics· Users education training and specialization· Trazability and viability studies· Turn key and management of solutions