VOLUME 219 OCTOBER-DECEMBER 1981

HOUSTON BAKER

THE JOURNAL OF

PharmacologyAND EXPERIMENTAL THERAPEUTICS

FOUNDED BY JOHN J. ABEL 1909

Official Publication of The American Society forPharmacology and Experimental Therapeutics, Inc.

EDITOR

Eva King Killam

ASSISTANT EDITOR

Mannfred A. Hollinger

EDITORS FOR SPECIFIC FIELDS

Analgesia and Drug Abuse

Joseph Cochin

Autonomic Pharmacology

Robert E. Stitzel

Behavioral Pharmacology

John A. Harvey

Cardiovascular Pharmacology

Henry R. Besch, Jr.Theodore M. BrodyDonald V. Priola

Cell Pharmacology

Toshio NarahashiGeorge B. Weiss

Chemotherapy

H. George Mandel

Developmental Pharmacology

Bernard L. Mirkin

Drug Metabolism and Disposition

Edward BresnickVincent G. Zannoni

Endocrine Pharmacology

Paula H. Stern

Gastrointestinal Pharmacology

Thomas F. Burks

Immunopharmacology

Sydney Spector

Neuropharmacology

S. J. Enna A. James HanceCharles 0. Rutledge

Pulmonary Pharmacology

Mannfred A. Hollinger

Renal Pharmacology

William 0. Berndt

Toxicology

Curtis D. Klaassen

EDITORIAL ADVISORY BOARD

Martin W. AdlerEdson X. AlbuquerqueEdmund G. AndersonLewis AronowLeslie E. BaileyPaul BassJohn A. BevanC. Paul BianchiLeslie C. BlaberDavid A. BlakeFloyd E. BloomCarl K. BucknerTheodore J. CiceroE. E. DanielWilliam C. de GroatJ. W. DownieLinda DykstraHugh L. EvansJames A. FerrendelliLawrence J. FischerWilliam W. FlemingRay W. FullerGerard L. GebberJames W. GibbShri N. GinDora B. GoldsteinFrank R. Goodman

Charles W. GorodetzkyGarrett J. Gross

T. Kendall HardenHarold F. HardmanLouis S. HarrisPhilip C. HoffmannJordan L. HoltzmanStephen G. HoltzmanJerry B. HookDavid M. JacobowitzDonald R JasinskiAlain F. JunodConan KornetskyEdwin A. KroegerWayne LevinLouis LevyBenedict R. LucchesiJohn C. McGiffDonald E. McMillanJerry MitchellPerry B. MolinoffW. H. MorseMary J. MycekRobert A. NealAchilles J. PappanoWilliam A. Pettinger

Larissa A. PohoreckyJames W. Putney, Jr.Arthur RainesG. Alan RobisonC. R. RossRonald P. RubinRobert R. Ruffolo, Jr.Betty I. SasyniukArnold SchwartzLewis S. SeidenEric J. SimonRoger P. SmithJohn L. SutkoRobert I. TaberA. E. TakemonRobert E. Ten EickThomas R. TephlyRichard E. TesselC. D. ThronU. TrendelenburgBetty M. TwarogNorman J. UretskyMartin A. WassermanRichard M. WelchDavid P. WestfallMartin M. WinburyBen G. Zimmerman

BOARD OF PUBLICATIONS TRUSTEES

NORMAN WEINER, Chairman; GEORGE I. DRUMMOND, LEON I. GOLDBERG, EVA KING KILLAM,NORMAN KIRSHNER, KENNETH C. LEIBMAN, ALAN H. CONNEY

WALTER MODELL, PAUL L. MUNSON

EXECUTIVE OFFICER OF THE SOCIETY

COPYRIGHT © 1981 BY THE WILLIAMS & WILKINS COMPANY

Editors forSpecific Fields

The Journal of

PHARMACOLOGYAND EXPERIMENTAL THERAPEUTICS

A Publication of The American Society

for Pharmacology and Experimental Therapeutics

Founded byJohnJ. Abel 1909

Editor

Assistant Editor

Eva King Killam

Mannfred A. Hollinger

EditorialAdvisoryBoard

Analgesia and Drug AbuseJoseph Cochin

Autonomic PharmacologyRobert E. Stitzel

Behavioral PharmacologyJohn A. Harvey

Cardiovascular PharmacologyHenry R. Besch, Jr.Theodore M. BrodyDonald V. Priola

Cell PharmacologyToshio NarahashiGeorge B. Weiss

Martin W. AdlerEdson X. AlbuquerqueEdmund G. AndersonLewis AronowLeslie E. BaileyPaul BassJohn A. BevanC. Paul BianchiLeslie C. BlaberDavid A. BlakeFloyd E. BloomCarl K. BucknerTheodore J. CiceroE. E. DanielWilliam C. de GroatJ. W. DownieLinda DykstraHugh L. EvansJames A. FerrendelliLawrence J. FischerWilliam W. FlemingRay W. FullerGerard L. GebberJames W. GibbShri N. GinDora B. GoldsteinFrank R. Goodman

ChemotherapyH. George Mandel

Developmental PharmacologyBernard L. Mirkin

Drug Metabolism and DispositionEdward BresnickVincent G. Zannoni

Endocrine PharmacologyPaula H. Stern

Gastrointestinal Pharmacology

Thomas F. Burks

Charles W. GorodetzkyGarrett J. GrossT. Kendall HardenHarold F. HardmanLouis S. HarrisPhilip C. HoffmannJordan L. HoltzmanStephen G. HoltzmanJerry B. HookDavid M. JacobowitzDonald R. JasinskiAlain F. JunodConan KornetskyEdwin A. KroegerWayne LevinLouis LevyBenedict R. LucchesiJohn C. McGiffDonald E. McMillanJerry MitchellPerry B. MolinoffW. H. MorseMary J. MycekRobert A. NealAchilles J. PappanoWilliam A. PettingerLarissa A. Pohorecky

ImmunopharmacologySydney Spector

NeuropharmacologyS. J. EnnaA. James HanceCharles 0. Rutledge

Pulmonary PharmacologyMannfred A. Hollinger

Renal PharmacologyWilliam 0. Berndt

Toxicology

Curtis D. Klaassen

James W. Putney, Jr.Arthur RainesG. Alan RobisonC. R. RossRonald P. RubinRobert R. Ruffolo, Jr.Betty I. SasyniukArnold SchwartzLewis S. SeidenEric J. SimonRoger P. SmithJohn L. SutkoRobert I. TaberA. E. TakemoriRobert E. Ten EickThomas R. TephlyRichard E. TesselC. D. ThronU. TrendelenburgBetty M. TwarogNorman J. UretskyMartin A. WassermanRichard M. WelchDavid P. WestfallMartin M. WinburyBen G. Zimmerman

Board ofPublications Trustees

Normal Weiner, ChairmanGeorge I. DrummondLeon I. Goldberg

Eva King KillamNorman KirschnerKenneth C. Leibman

Allan H. ConneyWalter ModellPaul L. Munson

Executive Officer Houston Baker

Published Monthly by The Williams & Wilkins Co., 428 E. Preston St., Baltimore, Md., 21202 U. S. A.Subscription price $120.00 per year individuals, $165.00 institutions, single issue $13.00. Second class postage paid at

Baltimore, Md. 21202 and at additional mailing offices

copyright © 1981 by The American Society for Pharmacology and Experimental Therapeutics

Made in the United States of America

TO AUGMENTYOUR EXPERIENCECLINICAL RESOURCES ©

from �LL�fS � �L�NSLet these two exciting titles join forceswith your professional abilities.

Try them out free for 20 days!

77777

Manual Of Clinical Pharmacology

Edited by David Robertson, MD, andCraig R. Smith, MD

It is well known that a core armamentarlum of

several dozen key drugs will suffice for the vastmajority of clinical situations. This handy new

manual gives you the most thorough under-standing possible of the drugs commonly used inclinical practice. and supplies an annotated bibli-ography on these drugs as a point of access to the

more detailed pharmacological literature. The

discussion sections are not intended to be com-plete reviews. They are provided to quickly iden-

tify drugs which are practical, d�fflcult� or new.You have to have some knowledge of all of thethousands of drugs on the market.. . but youshould have a very thorough understanding of the

few dozen drugs that are most frequently used.This little book highlights those areas that aretruly most important to you.

Contents: Antibiotics. Antihypertensives. Anti-arrhythmics and cardiovascular drugs. Diuretics.

Drugs affecting neurotransmission. Anticoagu-lants. Analgesics. Drugs affecting the central

nervous system. Oncologic agents. Drugs affectingthe endocrine system. Miscellaneous. Index.

1981/about 290 pages/$17.00(softeover)/7300-1

Practical ClinicalPsychopharmacologySecond Edition

William S. Appleton, MD and John M. Davis, MD

‘The authors, who posess impeccable credentials,have put together a handbook that is reliable,responsible,judicious, careful, and practicaL”

- from a review of the First Edition inModern Medicine

The authors call their book �‘a practical guide

based on solid science.” You will find it to be anindispensable manual of the latest clinical appli-

cations of psychopharmacology.

This new Second Edition distills the essentialinformation from more than 15,000 publishedarticles. It succinctly covers the diverse aspects ofpsychopharmacology and deals with the major

categories of useful pharmacotherapeutic agents.

Practical Clinical Psychopharmacology willprovide you with all the latest information so you

can prescribe psychotropic drugs rationally andcounter side-effects efficiently.

Contents: Before drug therapy begins. Choosing

an antipsychotic. Principles of prescribing anti-

psychotics. Pharmacological treatment for mood(affective) disorders. Anti-anxiety agents: adjunctsto psychotherapy. Medical emergency: overdose.Index.

1980/173 pages/lllustrated/$15.95/0238-4

ORDER TODAYYES, please send me these selections on 20-day

FREE approval:o Robertson Manual of Clinical Pharmacology

(7300-1) $17.00 [U.S.pricelo Appleton Practical Clinical Psychopharma-

cology (0238-4) $15.95 IU.S. price]I’ve checked the payment option below:

o Payment enclosed. I save all postage and handling

with full refund still guaranteed.

o BIll me.

Bill my VISA 0 MasterCard 0

Residents of CA, VA, MD, please add sales tax. Pricessubject to change without notice. Prices slightly higheroutside the U.S. Please pay in U.S. dollars.

TO ORDER TOLL FREE, CALL US TODAY at

1-800-638-0672 from 9 AM to 4 PM. From Maryland

phones. call 528-4221 collect.

Name

Address

card” exp. date City/State/Zip

Williams & Wilkins Department 363 P.O. Box 1496 Baltimore, Maryland 21203

AUTHOR INDEX

Axelson, J. E., 141Bagwell, E. E., 187

Barrett, J. E., 199

Beamish, R E., 225Beek, D., 112Bellville, J. W., 156

Bend, J. R., 27, 35Bhattacharyya, M. L, 75Bloch, R., 213Bousquet, P., 213

Brink, C., 1

Burley, E. 5., 268

Carrol-Buatti, M., 192

Chou, R. C., 42Commissaris, R. L., 170

Cordova, M. A., 187

Cox, R H., 35

Darius, H., 243

de Montellano, P. R. 0., 125Dhalla, N. S., 225D’Mello, G. D., 60

Dols, D. M., 125

Douglas, J. 5., 1

Duncan, P., 1Elmamlouk, T. H., 27

Fedan, J. S., 163

Feldman, J., 213Fish, K. W., 258

Fleming, W. W., 163

Fliegel, L., 225

Fredholm, B. B., 235

Freed, C. R., 49Friedman, E., 121

Fukuzawa, K., 219Gabathuler, M. L., 156

Galinsky, R �., 14

Ganong, W. F., 85

Gibson, T. P., 54Goldberg, D. M., 60Goldberg, S. R., 60

Gruetter, C. A., 181

Gruetter, D. Y., 181Halsema, I. C. M., 134

Hernandez, 0., 35Hoffer, B. J., 91Holiday, J. F., 258

Huang, K. C., 69

� L. J., 181Jacobowitz, D., 250

Jacobs, R. S., 268

Johnson, E. E., 274

Kadowitz, P. J., 181

Kapil, R. P., 141Karmazyn, M., 225

Katz, J. L., 199Kaufman, R. D., 156Kenakin, T. P., 112

Koster, H., 134

Kume,T., 219Langer, S. Z., 235

Levin, R. M., 250

Levy, G., 7, 14, 42

Lindenmayer, G. E., 187Lowery, C., 207

Luby, J. L., 258

Lucheli-Fortis, M. A., 235Lyness, W. H., 170

Lyon, J. E., 181

Malkowicz, S. B., 250

Marrazzi, M. A., 258Mathews, W. R., 91

McErlane, B., 141McNeil, J. H., 231

Melchior, C. L., 175Mico, B. A., 125Moore, K. E., 170

Morgan, M. E., 49Muakkassah, S. F., 147

Mukhtar, H., 27

Mulder,G.J., 134

Murphy, R. C., 91Nelson, T. E., 107

Oguma, T., 7

Ohlendorf, R., 243Ongley, R., 141Orion, T. C., 207Palmer, M. R., 91

Pang, K. S., 134

Pasternak, G. W., 192Price, J. D. E., 141

Quintanilla, A. P., 54

Rech,R.H., 170Riegelman, S., 125

Riggs, K. W., 141

Rodgers, R. L., 231

Sax, R. D., 21

Scholtens, E., 134

Schr#{246}r, K., 243Schwartz, J., 213

Silber, B., 125Simpson, W. W., 231Smith, B. R., 35

Spiegel, K., 192Steele, J. W., 35

Stolerman, I. P., 60Tabakoff, B., 175

Takimoto, G. S., 97

Tam, Y. K., 141Tokumura, A., 219Tsukatani, H., 219Valentine, J. 0., 199

Van De Kar, L. D., 85Vassalle, M., 75

Wein, A. J., 250

Weiner, N., 97Westfall, D. P., 163Westfall, T. C., 21

Wilkinson, C. W., 85

Williams, W. M., 69Wong, S. K., 163

Yagen, B., 35Yang, W. C. T., 147Yocca, F. D., 121

The Journal of Pharmacology and Experimental Therapeutics

Notice to Contributors (Effective .July 1976)

Scope of Submitted ManuscriptsThe Journal invites for review original papers dealing withany aspect of interactions of chemicals with biological

systems. Both terms-”chemicals” and “biological sys-tems”-imply as general ap�ilication as possible. Manu-

scripts dealing primarily with new methods will be re-viewed only if the methods are shown to lead to new or

more reliable data than were previously attained.

Organization of the Manuscript.

In most cases manuscripts should contain the followingsections in the order listed: 1) title page; 2) running title

page; 3) abstract; 4) introduction; 5) methods; 6) results; 7)

discussion; 8) acknowledgments; 9) references; 10) foot-

notes; 1 1) tables; 12) legends for figures; and 13) figures.

Each section should begin on a new page.

Submission of Manuscripts.Two typewritten copies, double-spaced on 21.6- by 28-cm

paper, should be sent to Dr. Eva King Killam, Departmentof Pharmacology, School of Medicine, University of Cali-fornia, Davis, California 95616. Pages should not be stapled

together.

It is understood that neither the manuscript nor the

data it contains have been previously published nor are

being submitted elsewhere for publication.

If and when the manuscript is accepted for publication,it will be necessary for the American Society for Pharma-cology and Experimental Therapeutics, Inc., to receive in

writing assignment of copyright from all authors of eachmanuscript. The forms for this assignment will be mailedfrom the Editorial Office.

1. Title page. This should contain the complete title

of the manuscript, the names of all authors, and the labo-ratory of origin.

2. Running title page. Each published paper needsa running title, which appears at the top of each page inthe Journal. The running title should contain no more than

35 spaces, including punctuation. It should convey thesense of the full title. Commonly used abbreviations (such

as “ATP,” “ACh,” etc.) may be used in the running title.This page should also contain the name and address of theperson to whom galley proof should be sent.

3. Abstract. Each published paper should be pre-ceded by an abstract. The abstract should begin with thenames of the authors and the title of the manuscript. Itshould present in a concise form the purpose, the generalmethods, the findings, and the conclusions of the manu-

script. Abstracts should be limited to 200 words or less;

abstracts of more than 250 words will not be accepted.

4. Introduction. This section should not be labeled.It should contain a clear statement of the aims of thereported work, or of the hypotheses which the work was

designed to test. A brief account of the background of thereported work may aLso be given in this section.

5. Methods. This section should contain explicit, con-cisc descriptions of all new methods or procedures em-ployed in the work. Modifications of previously published

methods should be described. Commonly used methodsrequire only a citation of the original source. When meth-

ods are described, the description should be such as toenable the reader to judge their accuracy, reproducibility,reliability, etc. Very extended descriptions of methods may

be submitted for deposit with the American Society forInformation Science National Auxiliary Publications Ser.vice (NAPS) do Microfiche Publications, P.O. Box 3513,

Grand Central Station, New York, NY 10017. A text ref.erence or footnote stating that the full description is avail-able from NAPS permits interested readers to obtain the

information, and does not occupy an inordinate amount ofJournal space. There is a nominal charge to authors for

this procedure; those who request the complete informa-

tion from NAPS pay a small fee.

6. Results. This section ordinarily contains the ex-perimental data to be presented, but not extended discus-

sions of their significance. Results are usually easier for

readers to grasp if they are presented in graphic or tabularform, rather than discursively. Graphic presentation of

data is preferred over tabular presentation. Data shouldnot be needlessly repeated in text, tables, and figures.

Sufficient data must be given to allow readers to judge thevariability and reliability of the results. Statistical tests

used and the data analyzed should be explained so that the

interested but non-expert reader can interpret the findings.

7. Discussion. This section should be pertinent to

the results. Speculative discussion is not discouraged, butthe speculation should be based on the data presented.

The discussion should be as concise as possible, within the

limits of the ideas which the authors wish to propose.

8. Acknowledgments. These may be included atthe end of the body of the text of the manuscript, but

should have a separate heading.

9. List of references. In text citations, give the au-thor’s name and the year of publication (e.g., McCarthy,1952; Ruth and Gehrig, 1929). With more than two authors,the text citation should contain the name of the first

author, followed by “et al.,” and the date (e.g., Kennedy et

al., 1960). In the list ofreferences, entries are to be arrangedalphabetically by author, and not numbered. All authors’names are to be given. If reference is made to more than

one publication by the same authors in the same year,suffixes (a, b, c, etc.) should be added to the year in the

text citation and in the list of references.The list of references is to contain, ir� sequence, the

following information: authors’ names and initials, title ofthe cited article, title of the journal in which the articleappeared (abbreviated; see below), volume number of thejournal, inclusive pagination, and year of publication. Ab-breviations for journals should conform to the Biosis List

ofSerials (BioSciences Information Services of BiologicalAbstracts, Philadelphia, Pa. 19103). Citations of personal

communications or of unpublished observations should be

given in parentheses at the appropriate place in the text,

not in the list of references. A paper may not be cited as“in press” unless it has been accepted for publication. In

such cases, give the name of the journal.Except in extraordinary circumstances, no more than

four references should be cited in support of any given

point.

10. Footnotes. All footnotes to the title, authors’names, or text should be indicated by arabic numeral

V

A

Hz

Ci

cpm

dpm

r

m

A1 (spell out in text)

hr

mmsec

OC

gLD�, ED�, etc.

d., 1., dl-

i.v., i.p., s.c., i.m.

S.D.S.E.

gmol

Eq

�at

MN

%

The Journal of Pharmacology and Experimental Therapeutics

Copies of this Notice may be obtained free of charge from the Editor.

superscripts, not by letters or other symbols. The footnotesshould be typed in sequence on a separate page, not at the

bottom of the pages on which they appear. Footnotes to

tables are discussed under Tables, below.

11. Tables. Each table should be on a separate page.Tables should be numbered consecutively with arabic nu-merals, and should be designed to fit the column or page

size of the Journal. A brief descriptive title should be givenat the top of each table. The table number should be given

in capital letters, the title in boldface upper and lower case

letters (e.g., TABLE 3. Uptake of labeled drug by ratliver slices). The footnotes to the tables should be referredto by italicized lower case superscript letters ( a, b, c, etc.)and should appear beneath the table involved, not on aseparate page of the manuscript. Extensive tabular mate-rial not absolutely essential to the manuscript will be

accepted for deposit with the ASIS/NAPS (see “Methods,”above). In such instances a footnote in the published paperwill refer the interested readers to NAPS from which copiesmay be obtained.

12. Legends for figures. These should be numberedconsecutively in arabic numerals, and should appear on a

separate page of the manuscript. Legends should explain

the figures in sufficient detail so that repeated referral tothe text is unnecessary. Abbreviations in the legends shouldconform to those in the text (see “Abbreviations,” below).

13. Figures. Illustrations should be submitted in du-plicate as unmounted glossy photographic prints, no larger

than 8 by 10 inches. The authors’ name and address, andthe number of the figure should be placed on the back of

each print. Illustrations must be clear enough to permitreproduction without retouching, and legibility after reduc-tion to single-column size (approximately 3#{189}inches inwidth). Uniform symbolism should be used for all illustra-

tions in a manuscript. Symbols, numbers, and letters in theillustrations must be at least 1.5 mm in height after reduc-

tion to single column size. The title of each figure should

appear in the legend rather than on the figure itself. Pho-tomicrographs and electron micrographs should be labeled

with a magnification calibration in micro or Angstrom

units. A statement of the magnification should appear in

the figure legend.

Abbreviations.Magnitudes of variables being reported should be ex-pressed in numerals. Most abbreviations are used without

punctuation, with no distinction between singular and plu-ral forms (e.g., 1 mg, 25 mg). The usual prefixes are to beused for multiples or submultiples of the basic units (e.g.,

kg, g, mg, �Lg, ng, pg). The following abbreviations, or theirproperly prefixed multiples or submultiples, may be usedwithout defmition in the text, tables, and figures:

Units of massgram

mole

equivalent

microatom

Units of concentrationmolar (moles/liter)normal (Eq/liter)

percent

Units of electricityvolt

ampere

cycles/sec

Units of radioactivitycurie

counts per mmdisintegrations per mmroentgen

Units of length or volumemetermicron

Angstrom

liter

Units of timehourminutesecond

Miscellaneous

degrees of temperaturegravity

median dosesoptically isometric formsroutes of drug adminis-

tration

standard deviation

standard error

Whenever an abbreviation other than those above is to

be used in a manuscript, it is to be defined in the text or in

a footnote thereto, the first time it is used. Abbreviationsfor commonly used substances should be those recom-

mended by the Journal of Biological Chemistry. Abbre-viations for drugs may be used if properly defined on first

use, and if the chemical or generic name of the drug isgiven when the abbreviation is first used. Abbreviationsmay be used in the running title, but not in the full title ofmanuscript.

Drugs.Generic names should be used in text, tables, and figures.

Trade names may be mentioned in parentheses in the fir�text reference to the drug, but should not appear in titles,figures or tables. When a trade name is used, it should becapit.alized; generic or chemical names are not capitalized.

The chemical nature of new drugs must be given when itis known. The form of drug used in calculations of doses

(e.g., base or salt) should be indicated. When several drugsare used, it may save space to include a separate paragraph

in “Methods,” or a separate table or footnote, listing the

relevant information about all drugs employed.

Page Charges.Authors are assessed page charges at the rate of $30 perprinted page. With the galley proof, authors will receive a

request for information concerning such charges. These

charges will be assessed only if they involve no personalexpense to the authors.

The cost of a limited number of illustrations will beborne by the Journal: the cost of excessive numbers ofillustrations will have to be defrayed by the authors.

name

address

PTPTSDRMFIL

IEEF1�.It.� �

is it important to you?Three journals that guarantee you’ll be told what’s happening

NOW in pharmacology, physiology, and biochemistry.

PHARMACOLOGICAL REViEWSAn Official Publication of theAmerican Society for PharmacoIo�yand Experimental Therapeutics, Inc.

Editor: Paul L. Munson, Ph.D., School of

Medicine, University of North Carolina

Pharmacological Reviews is a showcase journal

for ideas that would otherwise be buried in the

mass of pharmacological literature. Important

review papers on the current status of a given

topic are allotted plenty of space (from 10 to 40

pages) to exhaustively cover that topic. A fine

balance is achieved in these articles, which are

written in a clear, simple and concise fashion so

as to be intelligible to non-specialists, yet are

precise and detailed enough to be of great interest

to experts in the field.

At various times, Pharmacological Reviews

has addres�sed such subjects as biochemical and

cellular pharmacology, drug metabolism anddisposition, renal pharmacology, neuro-pharmacology, behavioral pharmacology,

clinical pharmacology, and toxicology. Designed

specifically as a medium through which thoseinterested in these topics can communicate

directly, Pharmacological Reviews serves

the entire pharmacological community and isvital reading for physiologists, pharmacologists,

and biological chemists.

ThE JOURNAL OFPHARMACOLOGY ANDEXPERIMENTAL THERAPEUTicS

An Official Publication of theAmerican Society for Pharmacologyand Experimental Therapeutics, Inc.

Editor: Eva King Killam, Ph.D., School of

Medicine, University of California at Davis

Founded by John 1. Abel in 1909, this is one of

the oldest and most prestigious journals in

scientific research. Publishing original articleson all aspects of the interactions of chemical

and biological systems by some of the best known

authors in the field, The Journal of Pharma�

cology and Experimental Therapeutics ispractically a necessity for the specialist in either

research or applied physiology.

You’ll find full coverage of the biochemical

and cellular aspects of pharmacology; renal,

pulmonary, gastrointestinal, and cardiovascular

pharmacology; drug metabolism and disposition,

analgesia and drug abuse, and toxicology; auto-

nomic pharmacology; behavioral effects; and,finally, chemotherapy and immunopharmacology.

Each issue of this monthly periodical au�rages

over 200 pages and presents the very best in

research for the physiologist and pharmacologist.

DRUG METABOLISM ANDDISPOSmON: the biologicalfate of chemicals

An Official Publication of theAmerican Society for Pharmacologyand Experimental Therapeutics, Inc.

Editor: Kenneth C. Leibman, Ph.D.,University of Florida Medical School

The clinical, academic, or research professional

will find Drug Metabolism and Disposition

an essential medium for the rapid communi-

cation of research findings in this field. The

journal reports on the fate of drugs, toxicants,

and environmental and industrial chemicals in

(‘ito and in vitro. Specific areas of interest include

pathways and mechanisms of absorption,

distribution, metabolism, and excretion of

foreign compounds; relationships between

chemical and physical properties of compounds

and their metabolism and disposition; biological

and pharmacological control of these variables,

and methodology for their study. Research

reports and documentation, comments on

current literature, and letters to the editor,

previews, and announcements of interest to you

round out this journal.

Please enter my new subscription to the journals checked below. (Iunderstand that payment must be received before my subscription

can begin.)

Pharmacological Reviews (quarterly)

0 Personal: $20.00/yr.

0 Institutional: $25.O0/yr.

0 In-training: $14.00/yr.

0 Foreign: add $5.00/yr.

The Journal of Pharmacology and Experimental Therapeutics (monthly)

0 Personal: $100.00/yr.

0 Institutional: $120.00/yr.

0 Foreign: add $20.00/yr.

Drug Metabolism and Disposition: the biological fate of chemicals (bimonthly)0 Personal: $40.00/yr.

0 Institutional: $58.OO/yr.

0 Foreign: add $5.00/yr.

(In-training rates apply to residents, fellows, interns, and students. When requesting

this rate, which is limited to three years, please give training status and name of

institution.)

Members of the American Society for Pharmacology and Experimental Therapeutics

should order subscriptions to the official society journals through the American

Society for Pharmacology and Experimental Therapeutics, %50 Rockville Pike,

Bethesda, MD 20014

city state zip code

0 check enclosed 0 bill me

CREDIT CARD PURCHASE(Check one) 0 VISA 0 Master Charge

card # expiration date

TOLL-FREE TELEPHONE ORDERING (9 am to 4 pm)

Now, subscribing to any of these journals is as easy as making a phone call. To order

WITH OR WITHOUT CHARGE CARD. call 1-800-638-0672. Maryland

residents CALL COLLECT, 528-4221.

Williams & WilkinsDept. 310, P.O. Box 1496Baltimore, Maryland 21203