Page - 1

PRIVATE CIRULATION ONLY E-News: 44| January 2019

The Institution of Engineers (India)MADURAI LOCAL CENTRE

MONTHLY CONNECTFEBRUARY 2019Er.S.Rajagopal, FIE

Chairman

Er.R.Narayanasamy, MIEHon. Secretary

Dear Engineers,My Greetings to you!Last month, we had our experts discussion with Dhan Foundation in

Redesigning the Vandiyur Lake by redefining the purpose of the tank as per

the need of the local communities through multiple stakeholders'

convergence and Bringing adequate, unhindered and safe water to the tank

by redesigning existing tank cascade system and Periyar Main Canal system.

In continuation to our discussion at our centre, we were invited for one more

meeting held in the Maurai Corporation on 4th February in which the Commissioner Madurai

participated and discussed about the project proposal for developing the Vandiyur lake in to a

tourist spot. The consultant for the project Mr.Valliappan,Carbon Design, for Eco Restoration of

Vandiyur Tank, explained various amenities to be provided so that the revenue from the tourist

can be used for the maintenance of the tank and the facilities thereby the eco system can be

improved. As on 31st March 2019,our all India strength may be around 2.2 lakhs and hence our centre's

strength should be more than 2800 Members, which require an addition of (2800-2490=)318

Members in the coming three months. If every committee member take a challenge and add

more members, this target could be achieved easily.Thanking you in anticipation of your support and suggestion

Yours Sincerely,S.Rajagopal, Chairman9443060370

Dear Engineers,Warm greetings to you all.During the month of January 2019, we have conducted the programme as

per schedule. The details of Forth Coming events are also notified in this

Newsletter separately.I request all the Committee Members to extend their full cooperation to me in

Er.S.Rajagopal, FIE.,Chairman

Chairman’s Desk

Secretary's Desk

Er. R.Narayanasamy, MIE., Hon.Secretary

Page - 2

arranging large number of technical activity in each month, by inviting knowledgeable Resource

persons. Also for arranging seminars on the latest topic which will be useful to the engineering

fraternity.Now the HQ has issued a circular to verify and confirm, the address and contact details of the

following Senior Engineers, who have crossed the age of 90 for updating the data base

If the members nearby and those who are aware of them, come to know the correct details please

inform me urgently.I also request all our Corporate Members to attend all the Lecture Meetings and Seminars in large

numbers.Thanking you

R.Narayanasamy, MIE.,Mob:9443063984

Sl

No

Name & Address of the senior

Engineers

E. Mail Id Telephone No

1 F-0022361 Mr.S.Babington.FIE.,

31,Kakkan Street,

ShenoyNagar,Madurai-625020

2 F-0048689 Mr.K.Chakrapany.FIE.,

Rtd.Chief Engineer/TWAD,

Krishnammal Illam,Plot No:437,

Annanagar,Madurai-625020

erkchakra@

gmail.com

9443279736

3 F-0085185 Mr.S.Shanmugam.FIE.,

Rtd.Chief Engineer,

173.K.K.Nagar,Madurai-625020

4 F-0127546

Mr.P.R.Subramanian.FIE.,1.D.,Mahal

Vadambokhi Street, Madurai-625001

5 F-1013757

Mr.R.Ramachandran,553,K.K.Nagar,

Madurai-625020

9422193749

6 F-1032301

Mr.S.J.Krishnamurthy.FIE., C-98,

VeeraRaghava Perumal Street,

Thirunagar,Madurai-625006

Page - 3

READ IEI EPITOME EVERY MONTH. ALSO FURNISH THE NEWS ABOUT YOU

SUCH AS PUBLICATIONS OF PAPERS, BOOKS AND ABOUT YOUR NEW ACHIEVEMENTS,

WHICH WILL ALSO BE PUBLISHED IN THE FORTH COMING EPITOME AN DIGITAL MEDIA OF IEI

“ENGG TALK” OUR ONE MORE ELECTRONIC MEDIA HIGHLIGHTS RECENT DEVELOPMENTS &

TECHNICAL NEWS. READ ENGG TALK IN YOUR E. MAIL .

IF YOU DO NOT GET THESE PUBLICATIONS IN YOUR E.MAIL

PLEASE LOG IN TO OUR WEBSITE “ieindia.org” AND

UPDATE YOUR PROFILE FURNISHING CORRECT ADDRESS, E.MAIL ID AND MOBILE NUMBER.

READ OUR MADURAI LOCAL CENTRE NEWSLETTER - MONTHLY CONNECT

IN OUR Website:ieimadurailc.org

UTILISE IEI, MADURAI WATER TESTING LAB. TEST YOUR STORED RAIN WATER AND

PORTABLE WATER BEFORE USE, AT OUR LAB. DO NOT USE WATER FOR CONSTRUCTION

WITHOUT TESTING ITS SUITABILITY

WARM WELCOME TO THE NEWLY ENROLLED CORPORATE MEMBERS DURING -JANUARY-2018

Sl.

No

Membership

Number/Divisi

on

Name and Address Contact phone

Number

E.Mail ID

1 F-124889-4

CP

Prof.(Dr).MS.VIJAYALAKSH

MI.K.FIE

Professor and Head,

Dept.of Computer science and

Engg.,

RAMCO Institute of

Technology, Rajapalayam-

626117

Virudhunagar Dist

9486604522 vijayalakshmik

@ ritrjpm.ac.in

2 M-163814-3

CV

Mr.JEGATHEESWARAN.B.

MIE

16,1C-A, LBS Nagar,Perali

Road,

Virudhunagar-626001

Virudhunagar Dist

9884099542 jegatheesb@

gmail.com

3. M-163822-4

MC

Mr.S.MOHAMMED IMRAN,

MIE, 16.Gandhiji Street,

B.B.Kulam,Madurai-625002

9840969383 Inboximran.21

@ gmail.com

Page - 4

11 AM-184489-2

CH

Dr.MS.MALINI.R,AMIE.,

Scientist,Electro-Inorganic

Chemical

Division,CSIR_CECRI,

Karaikkudi-630003

Sivaganga-Dist

9994702399 rmalinieiod@ce

cri.res.in

4 M-163901-8

CV

Mr.DINESH KUMAR.R.C.

MIE.,

18,Khanpalayam cross street,

Madurai-625009

8681035123 rcdineshkumar

@ gmail.com

5 M-163902-6

MC

Dr.M.RAJKUMAR.MIE.,

2/285,Kamarajapuram,

Batlagundu-624202,

Dindigul Dist

9443805129 vathilairaj@

gmail.com

6 M-163909-3

CP

Mr.Siva Ganapathy

Subramanian. M., MIE.,

36,Thiruvalluvar Street,

Managiri 4th Street,

K.K.Nagar,Madurai-625020

7299062565 mailtosivam@

gmail.com

7 M-163946-8

CV

Mr.C.KARTHIK.MIE.,

Door.No:6-2-20K/7B,Master

Illam, NagalaPuram,Thirunagar,

BATLAGUNDU-624202

Dindigul Dt.

9944489969 Karthik7386@

hotmail.com

8 M-163955-7

CP

Dr.M.KALLAPPAN.MIE.,

Associate Professor,

Dept.of Computer Sceience and

Engg. RAMCO Institute of

Technology,Rajapalayam-

626117 Virudhunagar Dist

9003613335 kalsrajan@

yahoo.co.in

9 AM-184463-9

CV

Mr.PANNEER

SELVAM.N.,AMIE.,

2/253,Thandal Muthu Konar

Street,Narayanapuram, Madurai-

625014

9994322756 npanneerselvam

6@gmail.com

10 AM-184465-5

ET

Mr.GANESHA PERUMAL. D,

AMIE., Door

9940840471 dganesh84@

gmail.com

Page - 5

12 AM-184534-1

CV

Mr.NARESH.M, AMIE.,

5. Pandavar Compound,

Marudhu pandiar Nagar 1st

Street, Anna street,NARIMEDU,

Madurai-625002

9994366824 Nareshcivil001

@ gmail.com,

13 AM-184606 -

2 EL

Mr.SENTHURKUMARAN,G.,

AMIE

32,Bagath singh Street,Kamatchi

Nagar,Thirumangalam,Madurai-

625706

9944257677 ssenthurbe@

gmail.com

14 AM-184622-4

MC

Mr.MOHAMED YACOOB.J.

AMIE.,

14. Royal Garden, Seeni

Rowther Cross Street,Nagal

Nagar, Dindigul-624003

Dindigul Dist

9384231137 Mohamedyacoo

b77@gmail.com

15 AM-184680-1

CV

Mr.VIGNESH ASHWIN.M.,

AMIE, 2/48,Angaiyar kanni

Avenue, Arapalayam Cross

Road, Madurai-625016

9600622225 Vig,ash1992@

gmail.com

16 AM-184707-7

EL

MS.POORNIMA

GAYATHRI.S. AMIE.,

No:2.RSS STREET,

LAKSHMIPURAM,THENI-

625523

9047907947 poornimasanjee

vi@gmail.com

17 AM-184804-9

CV

Mr.MUTHUBALASUBRAMA

NIAN.M.,AMIE.,No:18,VELAV

ASTREET, Balaji

Nagar,Thirupparankundram,

MADURAI-625005

9790448884 M.mutha010@

gmail.com

18 AM-184808-1

CH

Mr.RAJA.C.,AMIE.,

4/335C.Karuppasamy Koil

Street,

Ammer Palayam,SATTUR-

9790829042 Chemraja86@ya

hoo.co.in

Page - 6

Think Tank

How Architectural Features affect Seismic Resistance of Buildings?There are several architectural features that critically influence the seismic resistance capacity

of structures. Building architectural features include overall shape, size and geometry, in

addition to how the earthquake forces are carried to the ground. Each of these architectural

features has significant bearing on the performance of the building during earthquakes.Regarding the importance of building configuration, Henry Degenkolb said that “If we have a

poor configuration to start with, all the engineer can do is to provide a band-aid – improve a

basically poor solution as best as he can. Conversely, if we start-off with a good configuration

and reasonable framing system, even a poor engineer cannot harm its ultimate performance

too much.”Therefore, at the planning stage itself, architects and structural engineers must work together

in order to avoid undesired architectural features and come up with good building

configuration.When irregular features are included in buildings, a considerably higher level of engineering

effort is required in the structural design and yet the building may not be as good as one with

simple architectural features.

Architectural Features affecting Seismic Resistance :1.Size of Buildings2.Horizontal Layout of Buildings3.Vertical Layout of Buildings4.Adjacency of Buildings

1. Size of BuildingsIn tall buildings with large height-to-base size ratio (as shown in Fig.1.a), the horizontal

movement of the floors during ground shaking is large which detrimentally affect the stability

of a structure, and it increases overturn tendency. With regard to short but very long buildings

(as in Fig.1.b), the damaging effects during earthquake shaking are many.Additionally, in buildings with large plan area like warehouses (Fig.1.c), the horizontal seismic

forces can be excessive to be carried by columns and walls. So, the aforementioned sizes of

buildings are highly likely to show poor performance during earthquakes.

Fig. 1: Buildings with one of Their Overall Sizes Much Larger or Much Smaller Than theOther two, Do not Perform Well During Earthquake

Page - 7

Fig. 2 : Toppling of Tall Building

2. Horizontal Layout of BuildingsIn general, buildings with simple geometry in plan (Fig.3.a) have performed well during strong

earthquakes. Buildings with re-entrant corners, like those U, V, H and + shaped in plan (as

illustrated in Fig.3.b), have sustained significant damage.Frequently, the bad effects of interior corners in the plan of buildings can be avoided by making

the buildings in two parts. For instance, an L-shaped plan can be broken up into two rectangular

plan shapes using a separation joint at the junction (Fig.3.c).Sometimes, simple plan cannot be used as the only strategy for improving performance of

buildings during earthquake, but other factors would play their role as well. For example,

simple plan structures with unequal distribution of columns/walls in plan are expected to suffer

significant damages during earthquakes. Buildings with such features tend to twist during

earthquake shaking. That is why both architectural and structural engineer need to cooperate to

design high seismic resistance structure.

Fig. 3: Simple Plan Shape Buildings Do Well During Earthquakes

Page - 8

3. Vertical Layout of BuildingsThe earthquake forces developed at different floor levels in a building need to be brought

down along the height to the ground by the shortest path. Any deviation or discontinuity in

the load transfer path lead to poor seismic performance of the building. There are several

vertical architectural and structural features that decline seismic capacity of buildings:

Vertical SetbacksBuildings with vertical setbacks such as hotel buildings with a few storeys wider than the rest

cause a sudden jump in earthquake forces at the level of discontinuity, as illustrated in Fig.4.

Unequal Column Height Along SlopesBuildings on sloppy ground have unequal height columns along the slope, which causes ill

effects like twisting and damage in shorter columns as can be noticed in Fig.6.

Fig. 4: Buildings with Vertical Setback

Fig. 5: Buildings with Soft Storey

Fig. 6: Buildings on Sloppy Ground have Long and Short Columns Which May Twist During Earthquake

Page - 9

Hanging or Floating ColumnsBuildings with columns that hang or float on beams at an intermediate story and do not go all

the way to the foundation, have discontinuities in the load transfer path as can be seen in Fig. 7.

Some buildings have reinforced concrete walls to carry the earthquake loads to the foundation.

Buildings, in which these walls do not go all the way to the ground but stop at an upper level, are

liable to get severely damaged during earthquakes.

4. Adjacency of BuildingsWhen two buildings are too close to each other, they may pound on each other during strong

shaking. This collision exacerbates as building height increases. Moreover, when building

heights do not match (Fig.8), the roof of the shorter building may pound at the mid-height of the

column of the taller one; this can be very dangerous

S. Ramanathan F.I.E.94440 2099096000 5649626-12-2018

Fig. 7: Buildings with Hanging or Floating Fig. 8: Pounding can occur between adjoiningbuildings due to horizontal vibrations of the two buildings

Fig. 9: Pounding of Adjacent Buildings During Earthquakes

Page - 10

Events held during the Month of January - 2019

1. 04-05.01.2019 All India Seminar on 'Gate way to Finite Element Analysis in Mechanical

Design', Madurai in association with KLN College of Engg at their premises.

The Inaugural Session started by 10.30 AM, .The session was presided over by Mr.P.Rajamani .FIE.,

Past Chairman, IEI, Madurai. The entire events were conducted by the Students' Chapter of

Mechanical Engg. Department/KLNCE.The invocation prayer song was sung by Mr.R.Ramkumar, III year Mech. After invocation the

traditional lighting of lamp was done by dignitaries on the dais. Dr.P.Udayakumar ,FIE Head

Prof/Mechanical delivered welcome address. .Mr.K.N.K.Karthik delivered his address wherein he

said that this seminar topic related to recent development in the field of FEA in Mechanical Design

and it is an exposure to the students outside their curriculum and requested the participants to

actively participate and know more from the resource persons so that it will be useful for their

Placement. During his felicitation address Dr.A.V.Ramprasad, Principal, highlighted about IEI

activities in their premises with the guidance and assistance of IEI, Madurai Local centre, in

organizing of various activities. And due to this the KLNCE Mechanical Branch Student Chapter was

awarded Best Chapter Award and the Staff Advisor D.P.Udayakumar was adjudged as Best Staff

Advisor in Tamilnadu. He wished the Participants and the Seminar a great Success. Then Er

R.Narayanasamy delivered his felicitation address. Mr.P.Rajamani, Past Chairman, IEI/MLC

delivered the Presidential address.

Er. M.K. Sundaresan, delivered the key note address highlighting importance

of Finite element analysis and its usages in various Industry.

Er. J. DHANRAJ Senior Technical Officer, CIPET, Madurai

delivered the lecture on the seminar topic

Dr.P. Udhayakumar, HOD, delivered the lecture on the seminar topic. Dr.P.Rajamani, Council Member distributing certificates.

Page - 11

In his address he thanked the KLNCE Chairman and the Management for giving full support for

conducting professional development activities for the Students and staff. He Thanked the Student

of Students Chapter for taking the responsibility of managing this event giving equal responsibility

to all the office bearers. He congratulated them for getting best Student Chapter award and Best

Staff Advisor award .He thanked the Resource person Er. M.K. Sundaresan, Head, (PMS / SDEG /

STR) Vikram Sarabai Space Centre, Trivandrum ,.Er. J. DHANRAJ Senior Technical Officer, CIPET,

Madurai for the interest shown by them in this Seminar.After exchange of pleasantries by the IEI/MLC and KLNCE with the Chief Guest and Resource

person, Ms.Judelyn Rajasri, III year Mech., introduced the Chief Guest to the audience. Then the

Chief Guest Er. M.K. Sundaresan delivered the key note address highlighting importance of Finite

element analysis and its usages in various Industry. He insisted that it should be implemented in

space sector .The resource person Er. J. DHANRAJ while offering felicitation said their company is

ready to employ the final year Students, if they have better exposure in FEA and have done projects

and also ready give internship.

Prof. Dr.P.Udayakumar thanked the President/IEI., Chairman, IEI, Mechanical Engineering Board

and Chairman, IEI/CATE for giving approval to conduct the Seminar under the aegis of MCDB. He

thanked the Chief Guest and Resource persons for accepting his request to participate in this One

day seminar.

He thanked the President Mr.K.N.K.Karthik for giving them full support and guidance in

conducting the Seminar. He also thanked the IEI/MLC Chairman, Hon. Secretary, Jt. Hon.

Secretary, Committee Members and the Principal, KLNCE for their support in organizing the

Seminar in a successful way.

Then five Technical sessions were conducted, Two by Er. M.K. Sundaresan, Head, (PMS / SDEG /

STR) Vikram Sarabai Space Centre, Trivandrum ,one session by. Er. J. DHANRAJ Senior Technical

Officer, CIPET, Madurai and two sessions by Prof P,Udhayakumar, HOD,Mechanical/KLNCE. In

the sixth session hands on training was given.

The valedictory Session was presided over by Mr.P.Rajamani,FIE., Council Member.

Mr.R.Narayanasamy, MIE, Hon .Secretary, Mr.M.Savari Raj. MIE, Jt. Hon. Secretary

andMr.V.MuthuVijayan, Corporate Member of IEI/MLC participated from IEI, Madurai Local

centre.

Mr.P.Udhayakumar convener and the organizing committee Members from KLNCE also

participated. The participants from various institute gave their feed back and said the sessions

gave them new exposure and the FEAST brochures and video on FEAST/Pre-Win developed

byISRO was very much useful.

Then the participation certificates were distributed by all those present from MLC/IEI and

Mr.Manikandan the co-ordinator delivered vote of thanks and the seminar came to end with

national Anthem.

Recommendation: The hands on training using video on FEAST/Pre-Win developed by ISRO may

be given to all students for which ISRO is willing to distribute the FEAST/Pre win free of cost.

Page - 12

2. Students' Chapters Faculty Advisers Meeting held on 29.01.2019 (Tuesday) at 11.00 am

at Madurai Local CentreStudents Chapters Faculty Advisers Meeting was held on 29.01.2019 (Tuesday), at 11.00 AM

at Madurai Local centre. Faculty Advisers from 13 Engineering Colleges and two Polytechnic

Colleges under Madurai Local Centre's Jurisdiction attended the meeting. Er.S.Rajagopal FIE,

Chairman Madurai Local centre, presided over the meeting. Mr P.Rajamani Council Member,

Mr.M.Savari Raj, Jt. Hon Secretary were on the dais. After invocation, the Chairman delivered the

welcome address. Dr.P.Udhayakumar/FIE., Committee Member/MC of Madurai Local centre and the

coordinator of this programme presented a PPT on IEI and the Student Chapter formation, Charting

of Programs for the student Chapter and the benefits of the IEI activities were explained . After his

presentation the Chairman requested the participants to give their suggestions.

Prof.Karthikeyan of Syed Ammal Engg College, Ramanathapuram asked about the process of

issue of Scholarship grant to the college students since he did not receive any reply for the

applications recommended from his college. Mr.Thirumurugan, Arasan Ganesan Polytechnic

college, Sivakasi requested to conduct soft skill training to the Students. Mrs.Yasodai, Sethu Institute

of Technology, Pulloor asked to explain the R& D grants issued by the IEI and wanted to confirm

whether the Student should be SMIE or not. Prof.Muralitharan of MEPCO Engg College, Sivakasi

said his college was continuously getting Best Students Chapter awards earlier and wanted to know

is there any change in the norms. Mrs.Gajalakshmi of KLN College of Information technology,

Pottapalayam requested about the Grant for technical activity for the Institutional Members.

Mr.Amal Arockia Raj of RVS Engg College, Dindigul requested for the details about the Young

Engineer award. Prof.Srinivasa Raman,Mechanical Department, Sethu Institute of Technology

explained the Student Chapter activities arranged by him in his department. Mr.Vijaya

Raj,Coordinator of Mohamed Sathak college of Engg, Keelakarai explained that his college is

actively participating in all the students Chapter events and had been selected by the state centre for

best Division and Best Student awards. Er.R.Ponbadi, Past Chairman and Mr.D.Sankaramurthy,

Director, AMIE replied to the questions of the participants.

The Chairman requested the participants why the large percentage students are not

employable. He said IEI Madurai Local centre is going to organise a meeting of Human Resource

persons in this area and also programming to conduct the soft skill training based on their

suggestions. Requested the support of the participant colleges for such activities.

He requested the Principals of all the colleges to make all the passed out Students to be

Member of IEI as soon as the results are declared based on the Provisional certificate and the mark

list and distribute the AMIE professional Membership certificate along with the Degree certificate

which will boost the morale of the Degree holder and make him proud of recognizing his

qualification by a professional body.

The Joint Honorary Secretary Mr.M.Savari Raj delivered vote of thanks. The meeting was

adjourned after National Anthem.

Page - 13

3. Lecture meeting held at IEI, Madurai Local Centre on 29.01.2019 at 6.00 PM on the topic

“Education and Innovation”

A Lecture meeting was held on 29th January 2019 at 6.00 p.m. on the topic “ Education and

Innovation” at Madurai Local Centre Dr.Prof. YSM. P. Ashok Kumar, M.A., M.Ed., B.G.L. D. Litt

(USA),. COC, Manayakarasai Group of Educational Institutions, Madurai delivered the lecture on

the topic “Education and Innovation”. The meeting was presided over by Er.S. Rajagopal,

Chairman, Madurai Local Centre.

Dr.P. Rajamani, Former Vice President and Er.R. Narayanasamy, Hon. Secretary and

Er.M. Savari Raj, Jt. Hon. Secretary were on the dais. The Chairman delivered the welcome address

after the invocation. Mr. K. Muthuraj, FIE., Committee Member introduced the chief guest to the

audience. Er.R.Ponbadi, Past Chairman honoured the Chief Guest with a shawl.

The Chief Guest Dr.Prof. YSM. P. Ashok Kumar in his speech said education and innovation

are two side of the coin. He cited various examples of the latest innovation and scientific

developments. He said today's students are well exposed to the latest developments. What we need

is only ignite their mind. The Engineers profession needs industrial support for the innovation,

beside the Govt's. encouragement. He cited various examples from the latest news reports.

Chief Guest delivered the lecture on the topic Members and Audiences

Er.A. Durairaj, Past Chairman presented the Mementos

to the Chief Guest.Members and Audiences

Page - 14

After his speech there were lot of interaction which he replied enthusiastically and

encourage the participants. Er.A. Durairaj, Past Chairman presented the Mementos to the Chief

Guest. Er. M. Savai Raj, Jt. Hon. Secretary delivered vote of thanks. The meeting was adjusted after

National Anthem.

from research organizations

Why getting enough sleep reduces cardiovascular disease riskSleep-modulating hormone hypo cretin found to also control production of inflammatory cellsDate: February 13, 2019Source: Massachusetts General HospitalSummary:Getting enough sleep is key to good health, and studies have shown that insufficient sleep

increases the risk of serious problems, including cardiovascular disease. Now investigators have

discovered one way that sleep protects against the development of atherosclerosis.

1. 01, 02-2-2019, All India Seminar on the theme 'Green Manufacturing' under the aegis

of Production Engineering Division in association with K.L.N. College of Engineering.

2.05, 06-2-2019, All India Seminar on 'Materials for Energy Conversion and Storage', in

association with Kamaraj College of Engg and Technology, under the aegis of Mechanical

Engg Division Board

Science News

FORTH COMING EVENTS

WHAT IS NEW?

Images of plaque from the artery of a mouse model of atherosclerosis that experienced a normalsleeping pattern (left) and an image of arterial plaque from a mouse model that underwent sleep

fragmentation (right). The amount of arterial plaque in the sleep-fragmented mouseis significantly larger.

Page - 15

Credit: Filip Swirski, Ph.D., Harvard Medical School

Getting enough sleep is key to good health, and studies have shown that insufficient sleep

increases the risk of serious problems, including cardiovascular disease. Now Massachusetts

General Hospital (MGH) investigators have discovered one way that sleep protects against the

buildup of arterial plaques called atherosclerosis. In their paper receiving advance online

publication in Nature, they describe the mechanism by which insufficient sleep increases

production of inflammatory white blood cells known to be major contributors to atherosclerosis.

"We have discovered that sleep helps to regulate the production in the bone marrow of

inflammatory cells and the health of blood vessels and that, conversely, sleep disruption breaks

down control of inflammatory cell production, leading to more inflammation and more heart

disease," says Fillip Swirski, PhD, of the MGH Center for Systems Biology, senior author of the

Nature paper. "We also have identified how a hormone in the brain known to control wakefulness

controls processes in the bone marrow and protects against cardiovascular disease.”

To investigate how insufficient sleep increases atherosclerosis, Swirski's team subjected mice

genetically programmed to develop atherosclerosis to repeated interruptions of their sleep,

similar to the experience of someone constantly waking up because of noise or discomfort. While

there were no changes in weight, cholesterol levels or glucose tolerance in the sleep-deprived

mice, compared to animals from the same strain allowed to sleep normally, those subjected to

sleep fragmentation developed larger arterial plaques and had higher levels of monocytes and

neutrophils -- inflammatory cells that contribute to atherosclerosis -- in their blood vessels.

Further experiments revealed that the sleep-deprived mice had a nearly two-fold increase in

the production in their bone marrow of stem cells that give rise to white blood cells. A hormone

called hypocretin, produced in the brain structure called the hypothalamus and known to have a

role in the regulation of sleep, was found to play an unexpected role in controlling white blood cell

production. While normally produced at high levels when animals -- including humans -- are

awake, hypocretin levels were significantly reduced in the sleep-deprived mice.

The MGH team found that hypocretin regulates production of white blood cells through

interaction with neutrophil progenitors in the bone marrow. Neutrophils, they discovered, induce

monocyte production through release of a factor called CSF-1, and experiments with mice lacking

the gene for hypocretin revealed that the hormone controls CSF-1 expression, monocyte

production and the development of arterial plaques. In sleep-deprived animals, the drop in

hypocretin led to increased CSF-1 production by neutrophils, elevated monocyte production and

accelerated atherosclerosis.

"This is a direct demonstration that hypocretin is also an important inflammatory mediator,"

says Swirski, an associate professor of Radiology at Harvard Medical School. "We now need to

study this pathway in humans, explore additional mechanisms by which proper sleep maintains

vascular health and further explore this newly identified neuro-immune axis."

Page - 16

Story Source:Materials provided by Massachusetts General Hospital. Note: Content may be edited for

style and length.

Journal Reference:1. McAlpine CS, Kiss MG, Rattik S, He S, Vassalli A, Valet C, Anzai A, Chan CT,

Mindur JE, Kahles F, Poller WC, Frodermann V, Fenn AM, Gregory AF, Halle L, Iwamoto Y, Hoyer

FF, Binder CJ, Libby P, Tafti M, Scammell TE, Nahrendorf M, Swirski FK. Sleep modulates

haematopoiesis and protects against atherosclerosis. Nature, 2019 DOI: 10.1038/s41586-

019-0948-2

Cite This Page:Massachusetts General Hospital. "Why getting enough sleep reduces cardiovascular

disease risk: Sleep-modulating hormone hypocretin found to also control production of

i n f l ammato r y ce l l s . " S c i ence Da i l y. S c i ence Da i l y, 13 Feb rua r y 2019 .

<www.sciencedaily.com/releases/2019/02/190213132317.htm>

Editor:

Madurai Local Centre,

Er.T.M.JAMBULINGAM BHAVAN,

No.1, 120 Feet Road, Surveyor Colony,

K.Pudur, Madurai-625007.

Phone-0452 - 4373067

Web: www.ieimadurailc.org

E.mail: iei_mrc@yahoo.in,

madurailc@ieindia.org

Er.R.Narayanasamy, M.I.E.,Hon. Secretary

The Institution of Engineers(India),

Editorial Board:

Er.S.Rajagopal, FIE.,

Er.P.Rajamani.FIE.,

Er.K.Vijayakumar, FIE.,

Er.R.Ponbadi, FIE.,

Dr.S.Ganapathy, FIE.,

Er.S.Subramanian, FIE.,

Er.A.Jaffer Sadiq Babu, MIE.

Er.M.Savariraj.MIE,

Chairman:

Committee: