The importance of HUMIDITY CONTROL in Pharmaceutical Industries Belén Sampedro Business Developer.
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Transcript of The importance of HUMIDITY CONTROL in Pharmaceutical Industries Belén Sampedro Business Developer.
The importance of HUMIDITY CONTROL in
Pharmaceutical Industries
Belén SampedroBusiness Developer
THE IMPORTANCE OF HUMIDITY CONTROL
The lack of humidity control affects:
• Comfort: Environmental Wellness
• Health: Respiratory diseases, viruses, bacteria, allergies, etc.
• Materials: Hygroscopic and corrosion.
• Static Electricity: Risk for materials and people. Discomfort.
DRYING SYSTEMS
Mechanical dehumidifiers (cooling +heating)
Sorption dehumidifiers
DFRA SERIES
• To reach dew points <10ºC
• To reach Absolute humidity points < 8,5 g/kg
• Desiccant dehumidification is more efficient at low relative humidity and temperature , and it’s cheaper than mechanical dehumidification a DBT<20ºC
• The best option and when both systems works better is by combining the mechanical (first step) and desiccant (second step)
• Most cases, the choice is not an easy decission. Energy cost will be the key factor
WHY SORPTION
16 g/kg
8,5 g/kg
<3,5 g/kg
FRESH AIR30ºC and 60%RH
HEATING COIL25ºC and 40%RH
Dessicant DEHUMIDIFIER32ºC and 12%RH <3,5 g/kg
COOLING COIL11ºC and 98%RH
COMBINED SYSTEMS
PHARMACEUTICAL INDUSTRYClean rooms and Laboratories
These industries require air humidity high precision control
PHARMA INDUSTRY APPLICATIONS
References:Boehringer Ingelheim, Bristol Myers Squibb, GSK, Normon, Lilly, Pfizer, Pharma Mar, Roche, Bayer, Sanofi Aventis, Schering-Plough, Wyeth, C.S.I.C., SGS.
REQUIRED CONDITIONS: 22ºC, 30%HR, 4,9 g/kg
Why do we need DRY AIR?
• To avoid the product absorves humidity
• To avoid condensation and microbiological problems in the storage
• To Increase blistering speed (more production)
• To decrease the number of maintenance interruptions
• Direct dry air inside the blistering cabinet (smaller size of the dehumidifier)
Application: BLISTERING
Application: STERILE AREA
REQUIRED CONDITIONS: 22ºC, from 10% to 30%HR (1,6 - 4,9 g/kg)
Why do we need DRY AIR?
• To avoid the product absorves humidity
• To avoid microbiological growth when low humidity
• Dry air mixed before the AHU
Application: GELATINE CAPSULES
REQUIRED CONDITIONS: 22ºC, from 4% to 10%HR (0,6 - 1,6 g/kg)
Why do we need DRY AIR?
• To dry the gelatine capsules
• To decrease non-quality products
• Direct dry air inside the cabinet
• To Increase drying process,more production
Application: ACCELA COTA MACHINE
REQUIRED CONDITIONS: 22ºC, 4%HR (0,6 g/kg)
Why do we need DRY AIR?
• To help coating the product
• To increase speed of production
• To decrease the dosage of powder coating
• To increase stability / product quality giving greater hardness
• To increase the hygienic quality of the product
• Direct dry air inside the coating pan
Application: PILLS PRODUCTION
REQUIRED CONDITIONS: 22ºC, from 30%HR
Why do we need DRY AIR?
• To avoid condensation on the product
• To ensure continuous production
• To decrease non-quality products
• To decrease the number of maintenance interruptions
• Direct dry air inside the cabinet
Application: FLUIDIZED BED
REQUIRED CONDITIONS: 45ºC-60ºC, 5%HR
Why do we need DRY AIR?
• To avoid fresh air (different) conditions
dependence
• To stabilize production times
• Allows to increase the temperature of dry
air without quality product change
• To decrease the cicle time, increasing the
capacity up to 20%
• Direct dry air inside the the fluidized bed
in parallel flux
• Air handling project in a Pharma Lab production area , Madrid.
• Outdoor air conditions T= 34ºC, RH= 43%, X= 15,68 g/kg
• Room set poin, design T= 21ºC, RH= 15%, X= 2,5 g/kg
• Corridor air conditons T= 22ºC, RH= 60%, X= 10,78 g/kg
• Three persons working in the room• No loads due to product lost in weight• Negative pressure from the corridor (infiltrations)
REAL CASE CALCULATION
Corridor 22ºC / 60%RH
10,78 g/kgCLEAN ROOM
Area num.421ºC / 15%RH / 2,5 g/kg
Infiltrations from the corridor
9,541 Kg/h
INFILTRATIONS scheme
Supply air: 1,9 g/kg to absorve the infiltrations
Extraction
1500 m3/h
DEHUMIDIFIER: Fresh air+ recirculating air drying
INSTALLATION REQUESTS
Internal humidity loads to be absorved 9,5 kg/h + fresh air loads 9 kg/h = TOTAL LOADS to absorve 18,5 kg/h
Thank you!!!