The Iatrogenic Major Bile Duct Injuries: Experience at Ibn Siena Hospital

The Iatrogenic Major Bile Duct Injuries:

Experience at Ibn Siena Hospital

MAM Ibnouf AM Masaad

Prof. MAM Ibnouf, FRCSEd. Omdurman Islamic university

MBDI

Bile duct injury was estimated1-3/1000 in Open Cholecystectomy 4-6/1000 Laparoscopic Cholecystectomy

1- Nuzzo G. Giuliante F. Giovannini,I et al. Bile Duct Injury During Laparoscopic Cholecystectomy. Results of an Italian National Survey on 56 591 Cholecystectomies. Arch Surg. 2005;140:986-992.

2- Windsor JA, Pong J. Laparoscopic biliary injury: more than a learning curve problem. Aust NZ J Surg. 1998; 68: 186-189.

3- Calvete J, Sabater L, Camps B et al. Bile duct injury during laparoscopic cholecystectomy: myth or reality of the learning curve? Surg Endosc. 2000; 14: 608-611.)

4- Kern KA. Medicolegal analysis of bile duct injury during open cholecystectomy and abdominal surgery. Am J Surg. Am J Surg. 1994; 168: 217-222.

5- Howes N, Chagla L, Thorpe M, et al. Surgical practice is evidence based. British Journal of Surgery 1997;84:1220–3. Prof. MAM Ibnouf, FRCSEd. Omdurman

Islamic university

• This rate may reach 14/10001,2

• mortality as high as 11/10003.

1- Gronroos J M. Unsuccessful Endoscopic Stenting in Iatrogenic Bile Duct Injury: Remember Rendezvous Procedure. Surgical Laparoscopy, 2007; 17(3):186-189,

2- Gentileschi P, Di Paola M , Catarci M, et al. Bile duct injuries during laparoscopic cholecystectomy. Surgical Endoscopy. 2004; 18 ( 2): 232-236.

3- Buanes T, Mjaland O, Waage A, et al. A population-based survey of biliary surgery in Norway: relationship between patient volume and quality of surgical treatment. Surg Endosc. 1998;12:852-855.Prof. MAM Ibnouf, FRCSEd. Omdurman

Islamic university

Learning curve

• “The incidence of BDI significantly decreased with increasing number of LCs performed, ranging from 0.9% for surgeons who had performed fewer than 150 LCs to 0.3% for those who had performed more than 450 LCs”*.

*Howes N, Chagla L, Thorpe M, et al. Surgical practice is evidence based. British Journal of Surgery 1997;84:1220–3.Prof. MAM Ibnouf, FRCSEd. Omdurman Islamic university

Mortality The mean mortality rate in 15 case series composed of a

total of 602 IMBDIs with a follow up period 1-7 years was 17(2.8%)1.

Poor results are associated with:1- delayed referrals,2- biliary peritonitis3- associated vascular injury4-other co-morbid factors resulting in as high as 9.4%

mortality rate2

1- Johnson SR, Koehler A, Pennington LK, Hanto DW. Long-term results of surgical repair of bile duct injuries following laparoscopic cholecystectomy. Surgery. 2000 Oct;128(4):668-77.

2- Flum DR, Koespsell T, Heagerty P et al. Common Bile Duct Injury During Laparoscopic Cholecystectomy and the Use of Intraoperative Cholangiogram: adverse outcome or preventable error. Arch Surg. 2001; 136:1287-1292.


• The mortality rate in 39 cases of Bisthmus type III and IV was reported to be 25%*.

*Chaudhary A, Chandra A, Negi SS, Sachdev A. Reoperative surgery for postcholecystectomy bile duct injuries. Dig Surg. 2002;19(1):22-7.


The experience at Ibn sina Hospital

• Period: Jan 1998 to date

• Exclusion criteria:

1- Residual CBD stone retrieved by ERCP

2- Post cholecystectomy bile duct injuries

managed successfully with endoscopic

stenting


Number: 85 patients

Male: female : 3:82

Mean (±SD) age: 38.6 ± 10.66, range 22- 66 years

Type of surgery: Open Chole 73(85.8%) LC 12(14.2%)

Mode of presentation: Jaundice:54(63.5%) Bile leak:31(36.5%)


bile leak jaundice Total

Open chole 27 46 73

Lap chole 4 8 12

Total 31 54 85

Massage: High tendency towards over sewing or over clipping bleeders


Method of diagnosis

• ERCP 47 patients• MRCP 28 “• Both 15 “


Types of injuries

• Bisthmus III and IV 68 cases

• Bisthmus type II 15 cases

• Unkown 02 cases Massage: Most of the cases are high injuries


Period of delay: Range 00 days* – 1 year

* 3 occurred at Ibn Siena Hospital: One in

laparoscopic workshop and the second by a surgeon under training and one

by registrar to right bile duct


Poor referrals reports

MassageERCP does show the surgeon the site and size of the upper stump he should use for reconstruction

• ERCP


MRCP


Bisthmus IV: high narrow ducts


Biliary peritonitis


Management

Initial drainage 23 patients

Rodney Smith (Mucosal graft) 55(64.7%)

Hepatico-jejunostomy 23(27%)

Repaired over T-tube 2(2.3%)

Died before reconstruction 2(2.3%)

Left abroad 3(3.5%)Prof. MAM Ibnouf, FRCSEd. Omdurman

Islamic university

Post-operative stenting

3 months 58pts

6 months 18pts

1.5-2 months 3pts


Hospitalization period:

Before surgery: 3-10 days

After surgery: 10 days -3 weeks

Operative time: 2.5 - 4 hours

Massage: reconstruction of IMBDI is technically difficult and has very high costs


Follow up

Stricture: 22 patients

Specific complications:

Recurrent Cholangitis 15(17.6%)

Biliary cirrhosis: 7(8.2%)

Intra-hepatic duct stones (Redo-surgery) 2 patients

Cirrhosis (Redo-surgery abroad) 1 patients


Stricture with stones


Type of surgery and outcome was dictated by the level of injury

complications Rodney-Smith Hepatico-jej T-tube Total

(n=55) (n=23) (n=2) 80

Cholangitis 13 2 … 15(17.6%)

Cirrhosis 6 1 … 7(8.2%)

PE 1 0 … 1(1.2%)*

Septicaemia 0 0 … ….

No complications 35 20 2 57(67%)

* DiedProf. MAM Ibnouf, FRCSEd. Omdurman

Islamic university

Outcome after 3 years follow up

No complications 57(67%)

Recurrent Cholangitis 15(17.6)

Cirrhosis 7(8.2%

Pulmonary embolisim 2(2.3%) Died

Septicaemia 2(2.3%) Died

Advanced cirrhosis hepatic failure 1(1.1%

Massage: Morbidity rate 22(25.9%)

Mortality rate 5(5.9%)Prof. MAM Ibnouf, FRCSEd. Omdurman

Islamic university

Out come of ligation & transection P 0.001

Bile leak Jaundice Total

(n=54pts) (31pts) 85

Cholangitis 12 3 15

Cirrhosis 6 1 7

PE 1 1

Septicaemia 2 2

No complications 33 29 60

Massage: IMBDI with bile leak tend to have poorer results


Adverse outcome

Died before reconstruction 2 Patients

Left abroad 3(1.5%)

Massage: In hospital death after reconstruction 1 Patient

Massage: 2 out of 3 Died after reconstruction abroad

Massage: Mortality rate 5(5.9%)


Where do we stand?Series Number of repairs M&M re-stricture/cholangitis

MacFadyen BV Jr 1998 561 27(4.9%)

Walsh RM 2004 133 46(35%)

Slater K et al 131 2(1.5%) one of them died

Ibn Siena Hospital 85 22(25.9%) five of them died

Chaudhary A et al 41 3(7%) one of them died

Walsh RM et al 1998 34 18(25%)

Johnson SR et al 2000 21 7(33.3%)

Al-Sebaye MI 17 7(41%)

Topal B et al 1999 16 4(25%) one of them died

Karvonen J 2007 14 3(26%) one of them died

Massage: Ibn Sina Series is the 4th biggest series

and the 4th in the rate of complicationsMAM Ibnouf1, A.Majid M. Massaad2 Iatrogenic Major Bile duct Injuries Injury. Sudan JMS Vol. 2, No. 3, Sep. 2007Mohammad A M Ibnouf, A. M. Massaad, Sulaiman S Fediel "Iatrogenic major bile duct injury in Sudan" Sudan Med. J. (19) 3; 2001: 36-39.


Conclusion1- IMBDI leads to life long morbidity and high

chances for mortality

2- High injuries are common in OC and LC and are difficult to repair.

3- Injuries leading to bile leak prevent ductal dilatation and hence are associated with high rate of re-stricture.


Conclusion4- Stents should be left till maturation of the

fibrous tissue of the anastomotic line matures.

5- Results of reconstructive surgery at Ibn Siena is comparable to reported literature.

6- National Cholecystectomy Registry:

to evaluate the real magnitude of the IMBDI. Prof. MAM Ibnouf, FRCSEd. Omdurman

Islamic university

The Iatrogenic Major Bile Duct Injuries: Experience at Ibn Siena Hospital

Documents

Transcript of The Iatrogenic Major Bile Duct Injuries: Experience at Ibn Siena Hospital