Advanced MRI Imaging Combined with Intraoperative MRI for Brain Tumors
The Human Connectome Project Mapping Brain Networks With MRI
Transcript of The Human Connectome Project Mapping Brain Networks With MRI
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www.mghcme.org
The Human Connectome ProjectMapping Brain Networks With MRI
Randy L. Buckner, PhD
Sosland Family Professor of Psychology and of Neuroscience,
Harvard University
Director of Psychiatric Neuroimaging, Massachusets General Hospital
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www.mghcme.org
Disclosures
My spouse/partner and I have the following relevant financial relationship with a commercial interest to
disclose:
Consultant Pfizer, Roche, Alkermes
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www.mghcme.org
Learning objectives
• To understand how MRI methods can map organization of brain networks.
• To understand limits of available techniques.
• To review recent discoveries that map the organization of brain networks important to higher-level brain function.
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Measuring Brain Networks in the Human
Diffusion
Intrinsic Activity
SEED REGIONCORRELATED
NETWORK
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Example Validation
Krienen and Buckner, 2009, Cerebral Cortex
Cerebro-Cerebellar Circuit
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Lu, Liu et al., 2011, J. Neurosci.
Example Validation
Cerebro-Cerebellar Circuit
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HumanMonkey
Korbinian Brodmann
Human Association Cortex is Dramatically Expanded
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Canonical Hierarchical Sensory-Motor Network
HumanHuman
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FEF SPL7A
(LIP?)
V3A
aMT+MT+
Yeo, Krienen et al., 2011, J. Neurophysiol.
Canonical Hierarchical Sensory-Motor Network
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Yeo, Krienen et al., 2011, J. Neurophysiol.
Maunsell and Van Essen, 1983, J. Neurosci.
Canonical Hierarchical Sensory-Motor Network
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FEF SPL7A
(LIP?)
V3A
aMT+MT+
Yeo, Krienen et al., 2011, J. Neurophysiol.
Canonical Hierarchical Sensory-Motor Network
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Yeo, Krienen et al., 2011, J. Neurophysiol.
Distributed Association Networks
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Yeo, Krienen et al., 2011, J. Neurophysiol.
Distributed Association Networks
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Yeo, Krienen et al., 2011, J. Neurophysiol. Goldman-Rakic (1988) Ann. Rev. Neurosci.
Distributed Association Networks
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Coupled to Hippocampal Memory System
Vincent et al., 2007, J. Neurophysiol.
Kahn et al., 2008, J. Neurophysiol.
Distributed Association Networks
Yeo, Krienen et al., 2011, J. Neurophysiol.
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Coupled to Hippocampal Memory System
Vincent et al., 2007, J. Neurophysiol.
Kahn et al., 2008, J. Neurophysiol.
External Attention
Internal Mentation
Distributed Association Networks
Yeo, Krienen et al., 2011, J. Neurophysiol.
(Andreasen et al., 1995, Am. J. Psychiatry)
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External Attention
Internal Mentation
Distributed Association Networks
Yeo, Krienen et al., 2011, J. Neurophysiol.
(Andreasen et al., 1995, Am. J. Psychiatry)
Remembering
95 Independent Studies
Andrews-Hanna, Saxe, & Yarkoni, 2014, NeuroImage
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Yeo, Krienen et al., 2011, J. Neurophysiol.
Fox et al., 2005, Proc. Natl. Acad. Sci.
External Attention
Internal Mentation
Distributed Association Networks
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Yeo, Krienen et al., 2011, J. Neurophysiol.
Control Network?
Distributed Association Networks
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Vincent et al., 2006, J. Neurophysiol.
Control Network?
Distributed Association Networks
Control Network
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Hill et al., 2010 Proc Natl Acad Sci
Control Network
Vincent et al., 2006, J. Neurophysiol.
Expansion in Human Evolution
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Relevance to Mental Illness
Vincent et al., 2006, J. Neurophysiol. Baker et al., 2013, JAMA Psychiatry
(See also Whitfield-Gabrieli et al., 2009, PNAS; Anticivic et al., 2013 Cereb Ctx; Yang et al., 2016 PNAS)
Typical
Psychosis
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Mueller…Liu, 2013 Neuron; Wang…Liu, 2015, Nat Neurosci;
Variability Across Individuals
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Group Association Network (n=1000)
Yeo, Krienen et al., 2011, J. Neurophysiol.
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Group Association Network (n=1000)
Braga and Buckner, 2017, Neuron
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Single Subject (24 MRI Sessions)
Braga and Buckner, 2017, Neuron
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Braga and Buckner, 2017, Neuron
Single Subject (24 MRI Sessions)
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Braga and Buckner, 2017, Neuron
Single Subject (24 MRI Sessions)
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Braga and Buckner, 2017, Neuron
Single Subject (24 MRI Sessions)
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Braga and Buckner, 2017, Neuron
Single Subject (24 MRI Sessions)
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Network A
Network B
Braga and Buckner, 2017, Neuron
Single Subject (24 MRI Sessions)
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Network B
Braga and Buckner, 2017, Neuron
Network A
Human Specialization for Higher Brain Function?
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Language
Courtesy of Rodrigo Braga
Geschwind’s Language Network
Human Specialization for Higher Brain Function?
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Language
Courtesy of Rodrigo Braga
Human Specialization for Higher Brain Function?
Mentalizing /
Theory of Mind
Remembering
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Developmental Specialization
Courtesy of Rodrigo Braga
Proto-OrganizationMature
Specialization
Early Development
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Courtesy of Rodrigo Braga
Proto-OrganizationMature
Specialization
Late Development
Developmental Specialization
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Human Neuromodulation
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Artificial Intelligence
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Conclusions
1) Human brain imaging methods are able to detect network organization in individual people.
2) Distinct networks that are distributed across the brain are specialized for language, social, and mnemonic functions.
3) The identification of the networks provide targets for neuromodulation but have not yet provided translatable clinical tests or interventions.