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Transcript of The Grant Renewal Review Process Nywana Sizemore, PhD Scientific Review Officer Molecular...
The Grant Renewal Review Process
Nywana Sizemore, PhD
Scientific Review Officer
Molecular Oncogenesis - MONC
Oncology I - Basic Translational - OBT
Integrated Review Group
National Cancer Institute-NCI New Grantee Workshop
Bethesda, MD
October 18, 2010
National Institutes of HealthU.S. Department of Health and Human Services
National Institutes of Health
Much of the biomedical research in the United States is supported by the Federal Government, primarily the National Institutes of Health (NIH)
National Institutes of Health
National Instituteon Alcohol Abuseand Alcoholism
National Instituteon Alcohol Abuseand Alcoholism
National Instituteof Arthritis andMusculoskeletal
and Skin Diseases
National Instituteof Arthritis andMusculoskeletal
and Skin Diseases
National CancerInstitute
National CancerInstitute
National Instituteon Drug Abuse
National Instituteon Drug Abuse
National Instituteof Environmental Health Sciences
National Instituteof Environmental Health Sciences
National Instituteon Aging
National Instituteon Aging
Eunice KennedyShriver National Institute
of Child Health andHuman Development
Eunice KennedyShriver National Institute
of Child Health andHuman Development
National Institute onDeafness and Other
CommunicationDisorders
National Institute onDeafness and Other
CommunicationDisorders
National EyeInstitute
National EyeInstitute
National HumanGenome Research
Institute
National HumanGenome Research
Institute
National Instituteof Mental Health
National Instituteof Mental Health
National Instituteof NeurologicalDisorders and
Stroke
National Instituteof NeurologicalDisorders and
Stroke
National Instituteof General
Medical Sciences
National Instituteof General
Medical Sciences
National Instituteof Nursing Research
National Instituteof Nursing Research
National Libraryof Medicine
National Libraryof Medicine
Center for Scientific Review
Center for Scientific Review
National Centerfor Complementary
and AlternativeMedicine
National Centerfor Complementary
and AlternativeMedicine
National Instituteof Allergy and
Infectious Diseases
National Instituteof Allergy and
Infectious Diseases
John E. FogartyInternational
Center
John E. FogartyInternational
Center
National Centerfor ResearchResources
National Centerfor ResearchResources
Clinical Center
Clinical Center
National Center on Minority Health andHealth Disparities
National Center on Minority Health andHealth Disparities
National Institute of Biomedical Imagingand Bioengineering
National Institute of Biomedical Imagingand Bioengineering
Office of the DirectorOffice of the Director
Center for InformationTechnology
Center for InformationTechnology
National Heart,Lung, and Blood
Institute
National Heart,Lung, and Blood
Institute
National Instituteof Dental andCraniofacial
Research
National Instituteof Dental andCraniofacial
Research
National Instituteof Diabetes andDigestive and
Kidney Diseases
National Instituteof Diabetes andDigestive and
Kidney Diseases
• Receives all NIH applications
• Refers them to NIH Institutes/Centers and to scientific review groups
• Reviews majority of grant applications for scientific merit
Your Application Goes to the NIH Center for Scientific Review (CSR)
Focal Point for Initial Review at NIH
CSR Mission Statement
To see that NIH grant applications receive fair, independent, expert, and timely reviews – free from inappropriate influences – so NIH can fund the most promising research.
First Level of Review
CSR or Institute Review
Scientific Review Group
(Study Section)
First Level of Review
CSR or Institute Review
Scientific Review Group
(Study Section)
Second Level of Review NIH Institute/Center Council
Second Level of Review NIH Institute/Center Council
Scientific Review Process
Dual Review System for Grant Applications
National Institutes of Health
Center for Scientific Review
Study Section
Institute
Advisory Councils and Boards
Institute Director
Assigns to IC & IRG/Study Section
Reviews for Scientific Merit
Evaluates for Relevance
Recommends Action
Takes Final Action
ResearchGrant Application
School or OtherResearch Center
InitiatesResearch Idea
ConductsResearch
Allocates Funds
Submits Application
Review Process for a Research Grant
Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec Jan Feb Mar Apr May Jun Jul
Cycle 1
Receipt
Referral
CouncilReview
Award
Cycle 2
Receipt
Referral
CouncilReview
Award
Cycle 3
Receipt
Referral
CouncilReview
Award
There are three overlapping cycles per year
Overall Timeframe from Submission to Award
Divisions and Integrated Review Groups (IRGs)
Translational and Clinical Sciences
Cardiovascular and Respiratory Sciences
Surgical Sciences, Biomedical
Imaging and Bioengineering
Musculoskeletal, Oral & Skin Sciences
Oncology 2: Translational Clinical
Vascular and Hematology
Physiological and Pathological Sciences
Endocrinology, Metabolism, Nutrition & Reproductive Sciences
Immunology
Infectious Diseases& Microbiology
Digestive, Kidney &Urological Systems
Neuroscience, Development and Aging
Brain Disorders &Clinical Neuroscience
Molecular, Cellular &Developmental Neuroscience
Integrative, Functional & Cognitive Neuroscience
Emerging Technologies &Training in Neuroscience
Biology of Development & Aging
Biobehavioral & Behavioral Processes
Risk, Prevention & Health Behavior
Population Sciences & Epidemiology
Healthcare Delivery & Methodologies
AIDS & AIDSRelated Research
AIDS, Behavioral and Population Sciences
Basic and Integrative Biological Sciences
Biological Chemistry & Macromolecular
Biophysics
Bioengineering Sciences& Technologies
Genes, Genomes & Genetics
Oncology 1: Basic Translational
Cell Biology
Interdisciplinary Molecular Sciences
& Training
Integrated Review Groups
Biological Chemistry & Macromolecular Biophysics
Bioengineering Sciences & Technologies
Oncology 1: Basic Translational
Cell Biology
Genes, Genomes & Genetics
Interdisciplinary Molecular Sciences & Training
Division of Basic and Integrative Biological Sciences
Cancer Molecular Pathobiology (CAMP)
Cancer Etiology (CE)
Cancer Genetics (CG)
Molecular Oncogenesis (MONC)
Tumor Cell Biology (TCB)
Tumor Microenvironment (TME)
Tumor Progression & Metastasis (TPM)
CSR Study Sections
Referral Officers
Professional scientists, most of whom also serve as scientific review officers of CSR study sections
Applications Are Assigned by:
• Institutes or Centers based on─Overall mission and guidelines of the Institute or Center
Specific programmatic mandates and interests of the Institute or Center
• Integrated Review Groups based on─Specific review guidelines for each Integrated Review Group (IRG)
Applications Are Assigned to:
Get Your Application to the Right Study Section!
• Review CSR Integrated Review Group and Scientific Review Group (Study Section) guidelines to identify a home for your application.
• Submit a Cover Letter!
Help Your Application Get to the Right Study Section
http://www.csr.nih.gov/
Cover Letter
The cover letter should be used for a number of important purposes:
•Suggest Institute/Center assignment
•Suggest review assignment
•Identify individuals in conflict
•Identify areas of expertise needed to evaluate the application
•Discuss any special situations
•Required for an electronic changed/corrected submission
It is NOT appropriate to use the cover letter to suggest specific reviewers.
Please assign this Phase I SBIR “Drugs for Retinoblastoma Treatment” to the following:
Institutes/Centers
National Cancer Institute – NCI
National Eye Institute – NEI
Scientific Review Group
Oncology Translational and Clinical IRG - OTC
Please do not assign this application to the following:
Scientific Review Group
Biological Chemistry and Macromolecular
Biophysics - BCMB
This study focuses on a new in vitro model for testing drugs for treatment of retinoblastoma, not the synthesis of new chemotherapeutic agents.
Sample Cover Letter
Peer Review in CSR
• CSR Study Sections are managed by a Scientific Review Officer (SRO) who is a doctoral-level professional, whose scientific background is close to the focus of the study section.
• Each CSR standing study section has 12-25 regular members who are primarily from academia.
• About 60-100 applications are normally reviewed at each study section meeting.
Role of the Scientific Review Officer
• Performs administrative and technical review of applications to ensure completeness and accuracy
• Selects reviewers based on broad input
• Manages study section meetings
• Prepares summary statements
• Provides any requested information about study section recommendations to Institutes/Centers and National Advisory Councils/Boards
Designated Federal Official with overall responsibility for the review process
Enhancing Peer Review Overview and Timeline
January 2009 May/June 2009
ReviewsJanuary 25, 2010
Submissions
• Phase out A2 resubmission of applications
• Identification of Early Stage Investigator (ESI) R01 applications
• Enhanced review criteria
• New 9-point scoring system
• Criterion scoring
• Structured critiques
• Score order review
• Clustering of New Investigator (NI) R01 & clinical applications
• Discussed/Not-discussed Applications
• Restructured applications to align with review criteria
• Shortened page limits and new instructions
Where Do We Find Reviewers?
• CSR Registry for Volunteer Reviewers?
• Successful applicants
• Recommendations from reviewers and NIH staff
• NIH RePORTER (http://projectreporter.nih.gov/reporter.cfm)
• Internet
• Scientific conferences
How Reviewers Are Selected for Study Section Service
• Demonstrated scientific expertise/research support
• Doctoral degree or equivalent
• Mature judgment
• Work effectively in a group context
• Breadth of perspective
• Impartiality
• Representation of women and minority scientists
• Geographic distribution
Before the Study Section Meeting
• Each application is assigned to 3 or more reviewers 5-6 weeks in advance
• Reviewer assess each application by providing: A preliminary Overall Impact score Criterion Scores for each of the 5 Core Review Criteria using the 1 - 9 scaleA written critique
At The Meeting • Order of Review
– The average of the preliminary Overall Impact score from the assigned reviewers determines the review order
– Discussions start with the application with the best average preliminary Overall Impact score
• Clustering of Review– New Investigator R01 applications are clustered– Clinical applications & other mechanisms may be clustered
(n ≥ 20)
• Not Discussed Applicationso About 50% applications will be discussedo Applications unanimously judged by the review committee to
be less competitive are not discussed.
Scoring
• Score applications on five review criteria using a scale of 1-9
• Preliminary overall impact/priority score using 1-9 scale
• Discussed applications receive an overall score from each eligible (i.e., without conflicts of interest) panel member, and these scores will be averaged to one decimal place, and multiplied by 10. The 81 possible priority scores will thus range from 10-90.
• All applications will receive scores:
Not discussed applications will receive initial criterion scores from the three assigned reviewers.
• Scores for each review criterion
• Critiques from assigned reviewers
• Administrative notes if any
If your application is discussed, you also will receive:
• An overall impact/priority score and percentile ranking
• A summary of review discussion
• Budget recommendations
Your Summary Statement
Summary Statement
New Indicator for Early Stage Investigators
Percentile: 29 Percentile in whole numbers
Impact/Priority Score in 10-90
range
A Window to Your Application: eRA Commons
eRA Commons is an online interface where a grant applicant can:
•Check submitted grant application for errors and warnings and view final image•Track review assignment, view review outcomes (score, summary statements), find contact info•Update Personal Profile to ensure Early Stage Investigator eligibility is in place•Submit pre-award information (just in time)•View Notice of Award and other key documents
And much more! https://commons.era.nih.gov/commons/
Check the Status of Your Application in NIH Commons
Summary Statement
Additions for Review
Preparing an Application
• Register with
Grants.gov & eRA
Commons
• Submit in response to
PA
• Follow Application Guide & Instruction
s
• Submit via your
organizational
representative
• Use error correction
window• Use eRA
Commons to track
Prepare to Apply & Register
Find Opportunity
Prepare Application
Submit, Track & View
Electronic Application Process
Who Can Answer Your Questions?
Before You Submit Your Application
• A Program Officer at an NIH Institute or Center• Scientific Review Officer
After You Submit
• Your Scientific Review Officer
After Your Review
• Your Assigned Program Officer
GrantsInfo: [email protected] – 301 435-0714
View the Videos
• NIH Peer Review Revealed
• NIH Tips for Applicants
http://www.csr.nih.gov/video/video.asp
• About CSRAbout CSR
• News and ReportsNews and Reports
• Peer Review Meetings
• Resources for Applicants Resources for Applicants
CSR Web Site: http://www.csr.nih.gov
Key NIH Review and Grants Web Sites
NIH Center for Scientific Review
http://www.csr.nih.gov
NIH Office of Extramural Research
http://grants.nih.gov/