The Genetic Code. The Wobble Hypothesis: Base-Pairing Involving the Third Base of the Codon is Less...
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The Genetic Code
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Transcript of The Genetic Code. The Wobble Hypothesis: Base-Pairing Involving the Third Base of the Codon is Less...
In molecular biology, a wobble base pair is a non-Watson-Crick base pairing between two nucleotides in RNA molecules.The four main wobble base pairs are guanine-uracil, inosine-uracil, inosine-adenine, and inosine-cytosine (G-U, I-U, I-A and I-C).
The thermodynamic stability of a wobble base pair is comparable to that of a Watson-Crick base pair. Wobble base pairs are fundamental in RNA secondary structure and are critical for the proper translation of the genetic code.