THE EFFECTS OF INTERMITTENT VITAMIN D3 SUPPLEMENTATION ON MUSCLE STRENGHT AND METABOLIC PARAMETERS IN POSTMENOPAUSAL WOMEN WITH TYPE 2 BIABETES: A RANDOMIZED CONTROLLED STUDY

INTRODUCTIONThe association between vitamin D deficiency and the development of metabolic syndrome and type 2 diabetes as well as decreased skeletal muscle mass has been reported but the effects of vitamin D supplementation on these parameters is still controversial.

Baseline characteristics in the intervention and control groups were: age 62.16 ± 7.62 vs 62.32 ± 8.00 years (p= 0.9), diabetes duration 11.1 ± 7.4 vs 8.95 ± 7.4 years (p=0.36), BMI 27.6 ± 5.3 vs 28.2 ±5.9 Kg/m2 (p=0.6), HbA1c 8.18 ± 2.13 vs 9.13 ± 2.12 % (p= 0.15), serum 25OHD 22.24 ± 3.98 vs 22.91 ± 4.21 ng/ml (p=0.6), with differences in sun index, BP, FPG, and serum lipids. At the end of treatment period 26% of the intervention and 48% of the control groups had 25OHD < 20 ng/ml. Handgrip strength improved significantly in the intervention group (right arm 17.4 ± 2.68 to 19.9 ± 3.53 Kg, p= 0.002; left arm 16.31 ± 2.6 to 18.46 ± 3.2 Kg, p< 0.001) but not in the control group (right arm 16.87 ± 3.99 to 17.93 ±  4.91 Kg, p= 0.101; left arm 16.13 ± 4.29 to 16.86 ±  4.79 Kg, p = 0.229). There were no significant differences in the distribution of BMI at baseline but more patients in the control group became obese at the end of the study period (p=0.014). There were no significant changes in mean FPG (155.5 ± 67.4 to 163.4 ± 87.9 mg/dl, p=0.7), PPG 213.5 ± 87.7 to 210.7 68.8 mg/dl, p=0.8), HbA1c (8.18 ± 2.13 to

CONCLUSIONVitamin D3 supplementation in doses equivalent to 942 IU/day improved isometric handgrip strength but had no effect on glycemic control in postmenopausal women with longstanding type 2 diabetes.

REFERENCES

METHODS38 patients with serum 25OHD < 30 ng/ml were randomly assigned to oral vitamin D3 (6600IU/week in 2 cc oil preparation) or 2cc olive oil weekly for 3 months with the study medication being administered under supervision in all subjects.

Roseane Silva, Luiz Griz, Juliana Maia, Manoel Soares Filho, Maria Paula Bandeira, Francisco BandeiraDivision of Endocrinology, Diabetes and Bone Disease, Agamenon Magalhães Hospital, University of Pernambuco Medical School, Recife, Brazil

www.ued-ham.org.br

SUN-262

RESULTS

OBJECTIVETo evaluate the effect of weekly vitamin D3 supplementation on metabolic parameters and muscle strength of postmenopausal women with type 2 diabetes.

8.67 ± 2.41 %, p=0.1), serum triglycerides (175.68 ± 86.5 to 169.63 ± 62.17 mg/dl, p=0.9), SBP (136.3 ± 12.7 to 139.42 ± 4.2 mmHg, p=0,4) and DBP (81.3 ± 7.4 to 83.0 ± 10.0 mmHg, p=0.4) with vitamin D supplementation. SBP increased significantly in the control group from 136.6 ± 18.6 to 141.4 ± 17.6 mmHg (p=0.04).

1- Suzuki A, Kotake M, Ono Y, et al. Hypovitaminosis D in type 2 diabetes mellitus: Association with microvascular complications and type of treatment. Endocrine Journal. 2006;53(4): 503-10.2- Palomer X, González-Clemente JM, Blanco-Vaca F, et al. Role of vitamin D in the pathogenesis of type 2 diabetes mellitus. Diabetes, Obesity and metabolism. 2008;10:185-97.3- Bandeira F, Griz L, Dreyer P, et al. Vitamin D deficiency: a global perspective. Arq Bras Endocrinol Metab. 2006;50(4):640-46.

Table 1. Caracteristics of study patients

DATA EXPRESSED AS MEAN (± SD) FOR CONTINUOUS VARIABLES

Figure 1. Handgrip strenght in the right arm before and after vitamin D suplementation

Figure 2. Handgrip strenght in the left arm before and after vitamin D suplementation

p= 0.002

p < 0.001

p = 0.101

p = 0.229