The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset...

76
Sixth Annual Intensive Update in Neurology 09/15-16/2016 1 The Dizzy Patient 2016 Judith White M.D., Ph.D. Medical Director, Balance Center Swedish Neuroscience Institute

Transcript of The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset...

Page 1: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

1

The Dizzy Patient 2016

Judith White MD PhD

Medical Director Balance Center

Swedish Neuroscience Institute

Sixth Annual Intensive Update in Neurology 0915-162016

2

VESTIBULAR LABYRINTH

Sixth Annual Intensive Update in Neurology 0915-162016

3

Objectives

bull Differentiate nystagmus of benign paroxysmal

positional vertigo canal variants

bull Discuss benefits of steroids in acute vestibular

neuritis

bull Review efficacy of intratympanic therapies in

Menierersquos syndrome

bull Describe symptoms of superior semicircular

canal dehiscence

bull Summarize evidence for acute vestibular

syndrome evaluation

Sixth Annual Intensive Update in Neurology 0915-162016

4

Dizziness

bull Most common complaint over age 75

bull 8 million annual US visits

bull Chronic dizziness (gt 2 weeks) affects 16 of self-

reported US population

bull 354 of US adults aged 40 and older have vestibular

dysfunction (National Health and Nutrition Examination

Survey 2001-2004Arch Inter Med 169 (10) 938-44

2009)

Sixth Annual Intensive Update in Neurology 0915-162016

5

History

bull 70 of dizzy patients can be diagnosed with a careful

history (Gufoni 2005)

bull Equilibrium is an unconscious sensation Few

descriptions exist to describe its absence

Sixth Annual Intensive Update in Neurology 0915-162016

6

History

Onset ndash detailed description of first episode and most

recent episode

ndash Character

ndash Frequency

ndash Duration (vertigo andor milder symptoms)

ndash Associated hearing loss or tinnitus

ndash Provoking factors (noise pressure changes position change)

Sixth Annual Intensive Update in Neurology 0915-162016

7

Neuro-otology Physical Exam

bull Otologic ndash check hearing and rule out active infection or

cholesteatoma

bull Oculomotor- saccade pursuit in vertical and horizontal

planes

bull Nystagmus ndash spontaneous gaze evoked and

positionalpositioning testing (best observed using

Frenzel lenses)

bull Special testing ndash head thrust head shake

Sixth Annual Intensive Update in Neurology 0915-162016

8

Peripheral Nystagmus

bull Jerk nystagmus (slow

and fast phase)

bull Direction fixed

bull Generally beats away

from affected ear

bull Worse in the

direction of gaze that

is towards the fast

phase

Sixth Annual Intensive Update in Neurology 0915-162016

9

Benign Paroxysmal Positional Vertigo (BPPV)

bull Vertigo of sudden onset and brief duration provoked by changes in head positionndash Lying down

ndash Rolling over in bed

ndash Bending over

ndash Looking up

ndash Washing hair in shower

ndash Dentist or beauty parlor

Sixth Annual Intensive Update in Neurology 0915-162016

10

Right Posterior BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

11

IncidencePrevalence of BPPV

bull Most common referred diagnosis in tertiary centers

bull 9 of randomly selected community dwelling elderly

(Oghalai JS et al 2000)

bull Incidence increases 38 with each decade of life

(Froehling 1991)

Sixth Annual Intensive Update in Neurology 0915-162016

12

Benign Positional Vertigo (BPPV)

bull Diagnosed with lateral supine head turns and Dix-

Hallpike positioning

ndash Latency

ndash Duration

ndash Fatigue

ndash Habituation

Sixth Annual Intensive Update in Neurology 0915-162016

13

DHT - Sitting

Sixth Annual Intensive Update in Neurology 0915-162016

14

DHT - HHR Orientation

Sixth Annual Intensive Update in Neurology 0915-162016

15

Dix-Hallpike to the Right

Sixth Annual Intensive Update in Neurology 0915-162016

16

Right posterior BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

17

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

18

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

19

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

20

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

21

Canalith Repositioning

bull R posterior

BPPV

CPT 95992

Sixth Annual Intensive Update in Neurology 0915-162016

22

Posterior semicircular canalith repositioning

Sixth Annual Intensive Update in Neurology 0915-162016

23

Supine Positional Tests

Sixth Annual Intensive Update in Neurology 0915-162016

24

Lateral SCC-BPPV

bull Short latency horizontal nystagmus provoked by supine bilateral head turns with prolonged duration and poor fatigability

bull Uncommon (2-15 of total BPPV)

bull Two formsndash Geotropic ndash beating towards undermost ear

ndash Apogeotropic ndash beating away from undermost ear

Sixth Annual Intensive Update in Neurology 0915-162016

25

Geotropic Lateral Canal BPPV

bull Patient is positioned

first to the right lateral

position ndash nystagmus

beats right

bull Patient is then

positioned to the left

lateral position and

nystagmus reverses

and beats left

Sixth Annual Intensive Update in Neurology 0915-162016

26

Left Geotropic Lateral Semicircular Canal BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

27

Repositioning Maneuvers for Geotropic Lateral Semicircular Canal (LSC) BPPV

bull Roll maneuver (Lempert Baloh)

ndash Patient rolls in 90 degree increments towards the good side

completely rolling over R LSC-BPPV repositioning shown

Sixth Annual Intensive Update in Neurology 0915-162016

28

Repositioning Maneuvers for Geotropic LSC BPPV

bull Gufoni maneuver

ndash Patient lies quickly onto good side and turns face-down to

floor for two minutes

Sixth Annual Intensive Update in Neurology 0915-162016

29

Left Apogeotropic LSC BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

30

Nystagmus observed During Repositioning

bull Nystagmus should remain in the same torsional

direction as seen on DHT throughout the treatment of

posterior BPPV

bull Reversal of nystagmus direction suggests the particle

has fallen back into the canal and predicts failure

bull In Lateral BPPV nystagmus should beat towards the

good ear

Sixth Annual Intensive Update in Neurology 0915-162016

31

Posterior to Lateral canal conversion

Sixth Annual Intensive Update in Neurology 0915-162016

32

R Posterior to Lateral Canal conversion - geotropic

Sixth Annual Intensive Update in Neurology 0915-162016

33

BPPV Recurrence

bull Recurrence is common (15yr)

bull Otoconial adherence or mineralization demineralization

abnormalities may contribute to recurrence

bull Home canalith repositioning is effective (Radke 2004)

Sixth Annual Intensive Update in Neurology 0915-162016

34

Question 1

bull The most likely semicircular canal to be affected in

BPPV is

ndash 1) superior

ndash 2) lateral

ndash 3) posterior

ndash 4) combined

Sixth Annual Intensive Update in Neurology 0915-162016

35

Question 1

bull The most likely semicircular canal to be affected in

BPPV is

ndash 1) superior

ndash 2) lateral

ndash 3) posterior

ndash 4) combined

Answer 3 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

36

Acute Vestibular Syndrome

bull Rapid unilateral injury to either peripheral or central

vestibular structures produces prolonged vertigo

(days to weeks)

bull Severe vertigo nausea and vomiting spontaneous

nystagmus and postural instability

Sixth Annual Intensive Update in Neurology 0915-162016

37

Acute Vestibular Syndrome

bull 25 of patients with risk factors who present with isolated severe vertigo nystagmus and postural instability in the ER have an acute infarction of the inferior cerebellum (AICA PICA) Central imaging is suggested (Baloh 1998 NEJM)

ndash HTN diabetes smoking age gt65 Afib valvular heart disease occlusive vascular disease

Sixth Annual Intensive Update in Neurology 0915-162016

38

HINTS test

bull Head Impulse

bull Nystagmus

bull Test of Skew

ndash More sensitive than MRI in the diagnosis of acute stroke in

patients with acute vestibular syndrome with at least one risk

factor (Kattah J et al Stroke 2009)

Sixth Annual Intensive Update in Neurology 0915-162016

39

Head Impulse Test

bull No special equipment needed

bull Examiner stands in front of seated patient and

randomly moves head left and right Patient is asked to

focus on examinerrsquos nose

bull Rapid low amplitude thrust from lateral to straight

ahead causes a compensatory saccade when

performed towards the weak side

bull This finding is a permanent feature of unilateral

vestibular loss

Sixth Annual Intensive Update in Neurology 0915-162016

40

Head Impulse Test

Sixth Annual Intensive Update in Neurology 0915-162016

41

Head CT ndash Academy of Emergency Medicine 2013

bull The clinical value of head CT in isolated

dizzinessvertigo without any associated neurological

symptoms is very low

bull Less than 1 of head CTs ordered for dizziness and

vertigo have significant abnormalities and those

patients had severe headache and neurological deficits

in addition to dizziness

bull Forgoing unnecessary emergency head CTs could

save 360 million dollars annually

Sixth Annual Intensive Update in Neurology 0915-162016

42

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Sixth Annual Intensive Update in Neurology 0915-162016

43

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Answer 2 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

44

Acute Vestibular Syndrome

bull Usually peripheral and can be associated with

hearing loss (labyrinthitis)

bull Timely diagnosis improves recovery (ASAP

prednisone 1mgkgday for ten days and taper 10

mgday ndash Strupp M 2004 NEJM)

bull Avoid vestibular suppressants after 3 days and begin

vestibular rehabilitation to hasten compensation

Sixth Annual Intensive Update in Neurology 0915-162016

45

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

46

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Answer 5 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

47

Menierersquos syndrome

bull Fluctuating low frequency hearing loss

bull Tinnitus andor aural fullness

bull Vertigo lasting hours

Sixth Annual Intensive Update in Neurology 0915-162016

48

Normal

Sixth Annual Intensive Update in Neurology 0915-162016

49

Hydrops

Sixth Annual Intensive Update in Neurology 0915-162016

50

Menierersquos syndrome

ndash Diagnosis- Exclusion (RO acoustic)

ndash 23 of Menierersquos patients will improve spontaneously

ndash Treatment-1500 mgday low sodium triamterene375-

hydrochlorothiazide 25 vestibular suppressants (lorazepam

1 mg tablet sublingual Q 8 prn attacks) off label use

Sixth Annual Intensive Update in Neurology 0915-162016

51

Menierersquos syndrome ndash intratympanic steroids

ndash A newer treatment option for those failing medical management

ndash 90 response rate (Boleus-Aguirre MS Otology Neurotology

2008)

ndash Outcomes data confirm excellent clinical response in 3941

Menierersquos patients treated with intratympanic steroids in 2008

Sixth Annual Intensive Update in Neurology 0915-162016

52

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

53

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Answer 5 See references at end

Sixth Annual Intensive Update in Neurology 0915-162016

54

Superior Semicircular Canal Dehiscence (SSCD)

bull Sound andor pressure induced oscillopsia

bull CT reformatted in the plane of the superior canals

shows dehiscence of overlying bone

bull Low frequency ldquoconductive hyperacusisrdquo with elevated

bone thresholds normal reflexes and a conductive loss

Sixth Annual Intensive Update in Neurology 0915-162016

55

SSCD

bull Positive middle ear pressure or loud sound stimulates ampullofugal endolymph flow -canal activation

bull Eye movements are tonic upwards with ipsilateral intorsion

Sixth Annual Intensive Update in Neurology 0915-162016

56

SSCD

bull Valsalva against a closed glottis or jugular compression causes increased intracranial pressure and ampullopetal endolymph flow -canal inhibition

bull Eye movements are tonic downwards with ipsilateral extorsion

Sixth Annual Intensive Update in Neurology 0915-162016

57

Reconstructed left superior semicircular canal

Sixth Annual Intensive Update in Neurology 0915-162016

58

Sixth Annual Intensive Update in Neurology 0915-162016

59

SCHEMATIC DRAWING OF AN OTOLITHIC MACULA

Sixth Annual Intensive Update in Neurology 0915-162016

60

MACULAE OF THE UTRICLESACCULE

Sixth Annual Intensive Update in Neurology 0915-162016

61

HAIR CELLS

Sixth Annual Intensive Update in Neurology 0915-162016

62

SCANNING ELECTRON MICROGRAPH OF OTOCONIA

Sixth Annual Intensive Update in Neurology 0915-162016

63

Ocular VEMP

bull Response to loud clicks (80-110 dB) or forehead tap (Halmagyi and Curthoys 2003)

bull Contralateral oculomotor nucleus (CN III)

bull Inferior oblique muscle contraction (8 msec) detected by 5sec event triggered averaging

bull Noninverting electrode inferior to eye

bull Inverting below non-inverting electrode

bull Ground to forehead

bull Normal subjects have very low response

Sixth Annual Intensive Update in Neurology 0915-162016

64

Clinical applications

bull The o-VEMP is a sensitive test of otolithutricular

function

bull Complements vestibular test procedures that assess

semicircular canals

bull Abnormally robust responses are associated with third

window abnormalities such as semicircular canal

dehiscence

bull Serves as an excellent screening test for semicircular

canal dehiscence

Sixth Annual Intensive Update in Neurology 0915-162016

65

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Sixth Annual Intensive Update in Neurology 0915-162016

66

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Answer 1 References at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

67

Enlarged vestibular aqueduct

bull Axial temporal bone CT showing right temporal bone with enlarged vestibular aqueduct (arrow)

bull Vestibular symptoms accompany progressive sensorineural hearing loss in 4-50 of patients in selected series

Sixth Annual Intensive Update in Neurology 0915-162016

68

Migraine

bull Family or personal history of migraine

bull 25 of migraine patients experience spontaneous vertigo (Baloh 1997)

bull Neuhauser criteria(2001) have been used to construct structured diagnostic interviews (Furman 2003)

bull Not always associated with headache

bull Motion sensitivity

bull Medication responsive

Sixth Annual Intensive Update in Neurology 0915-162016

69

ICHD-III beta Criteria for Vestibular Migraine

bull A At least five attacks fulfilling criteria C and D

bull B A current or past history of 11 migraine without aura or 12 migraine with aura

bull C Vestibular symptoms of moderate or severe intensity lasting between 5 minutes and 72 hours

bull D At least 50 associated with one of the following migrainous features

ndash 1 Headaches

ndash 2 Photophobia and phonophobia

ndash 3 Visual Aura

bull E Not better accounted for by another vestibular disorder

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 2: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

2

VESTIBULAR LABYRINTH

Sixth Annual Intensive Update in Neurology 0915-162016

3

Objectives

bull Differentiate nystagmus of benign paroxysmal

positional vertigo canal variants

bull Discuss benefits of steroids in acute vestibular

neuritis

bull Review efficacy of intratympanic therapies in

Menierersquos syndrome

bull Describe symptoms of superior semicircular

canal dehiscence

bull Summarize evidence for acute vestibular

syndrome evaluation

Sixth Annual Intensive Update in Neurology 0915-162016

4

Dizziness

bull Most common complaint over age 75

bull 8 million annual US visits

bull Chronic dizziness (gt 2 weeks) affects 16 of self-

reported US population

bull 354 of US adults aged 40 and older have vestibular

dysfunction (National Health and Nutrition Examination

Survey 2001-2004Arch Inter Med 169 (10) 938-44

2009)

Sixth Annual Intensive Update in Neurology 0915-162016

5

History

bull 70 of dizzy patients can be diagnosed with a careful

history (Gufoni 2005)

bull Equilibrium is an unconscious sensation Few

descriptions exist to describe its absence

Sixth Annual Intensive Update in Neurology 0915-162016

6

History

Onset ndash detailed description of first episode and most

recent episode

ndash Character

ndash Frequency

ndash Duration (vertigo andor milder symptoms)

ndash Associated hearing loss or tinnitus

ndash Provoking factors (noise pressure changes position change)

Sixth Annual Intensive Update in Neurology 0915-162016

7

Neuro-otology Physical Exam

bull Otologic ndash check hearing and rule out active infection or

cholesteatoma

bull Oculomotor- saccade pursuit in vertical and horizontal

planes

bull Nystagmus ndash spontaneous gaze evoked and

positionalpositioning testing (best observed using

Frenzel lenses)

bull Special testing ndash head thrust head shake

Sixth Annual Intensive Update in Neurology 0915-162016

8

Peripheral Nystagmus

bull Jerk nystagmus (slow

and fast phase)

bull Direction fixed

bull Generally beats away

from affected ear

bull Worse in the

direction of gaze that

is towards the fast

phase

Sixth Annual Intensive Update in Neurology 0915-162016

9

Benign Paroxysmal Positional Vertigo (BPPV)

bull Vertigo of sudden onset and brief duration provoked by changes in head positionndash Lying down

ndash Rolling over in bed

ndash Bending over

ndash Looking up

ndash Washing hair in shower

ndash Dentist or beauty parlor

Sixth Annual Intensive Update in Neurology 0915-162016

10

Right Posterior BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

11

IncidencePrevalence of BPPV

bull Most common referred diagnosis in tertiary centers

bull 9 of randomly selected community dwelling elderly

(Oghalai JS et al 2000)

bull Incidence increases 38 with each decade of life

(Froehling 1991)

Sixth Annual Intensive Update in Neurology 0915-162016

12

Benign Positional Vertigo (BPPV)

bull Diagnosed with lateral supine head turns and Dix-

Hallpike positioning

ndash Latency

ndash Duration

ndash Fatigue

ndash Habituation

Sixth Annual Intensive Update in Neurology 0915-162016

13

DHT - Sitting

Sixth Annual Intensive Update in Neurology 0915-162016

14

DHT - HHR Orientation

Sixth Annual Intensive Update in Neurology 0915-162016

15

Dix-Hallpike to the Right

Sixth Annual Intensive Update in Neurology 0915-162016

16

Right posterior BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

17

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

18

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

19

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

20

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

21

Canalith Repositioning

bull R posterior

BPPV

CPT 95992

Sixth Annual Intensive Update in Neurology 0915-162016

22

Posterior semicircular canalith repositioning

Sixth Annual Intensive Update in Neurology 0915-162016

23

Supine Positional Tests

Sixth Annual Intensive Update in Neurology 0915-162016

24

Lateral SCC-BPPV

bull Short latency horizontal nystagmus provoked by supine bilateral head turns with prolonged duration and poor fatigability

bull Uncommon (2-15 of total BPPV)

bull Two formsndash Geotropic ndash beating towards undermost ear

ndash Apogeotropic ndash beating away from undermost ear

Sixth Annual Intensive Update in Neurology 0915-162016

25

Geotropic Lateral Canal BPPV

bull Patient is positioned

first to the right lateral

position ndash nystagmus

beats right

bull Patient is then

positioned to the left

lateral position and

nystagmus reverses

and beats left

Sixth Annual Intensive Update in Neurology 0915-162016

26

Left Geotropic Lateral Semicircular Canal BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

27

Repositioning Maneuvers for Geotropic Lateral Semicircular Canal (LSC) BPPV

bull Roll maneuver (Lempert Baloh)

ndash Patient rolls in 90 degree increments towards the good side

completely rolling over R LSC-BPPV repositioning shown

Sixth Annual Intensive Update in Neurology 0915-162016

28

Repositioning Maneuvers for Geotropic LSC BPPV

bull Gufoni maneuver

ndash Patient lies quickly onto good side and turns face-down to

floor for two minutes

Sixth Annual Intensive Update in Neurology 0915-162016

29

Left Apogeotropic LSC BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

30

Nystagmus observed During Repositioning

bull Nystagmus should remain in the same torsional

direction as seen on DHT throughout the treatment of

posterior BPPV

bull Reversal of nystagmus direction suggests the particle

has fallen back into the canal and predicts failure

bull In Lateral BPPV nystagmus should beat towards the

good ear

Sixth Annual Intensive Update in Neurology 0915-162016

31

Posterior to Lateral canal conversion

Sixth Annual Intensive Update in Neurology 0915-162016

32

R Posterior to Lateral Canal conversion - geotropic

Sixth Annual Intensive Update in Neurology 0915-162016

33

BPPV Recurrence

bull Recurrence is common (15yr)

bull Otoconial adherence or mineralization demineralization

abnormalities may contribute to recurrence

bull Home canalith repositioning is effective (Radke 2004)

Sixth Annual Intensive Update in Neurology 0915-162016

34

Question 1

bull The most likely semicircular canal to be affected in

BPPV is

ndash 1) superior

ndash 2) lateral

ndash 3) posterior

ndash 4) combined

Sixth Annual Intensive Update in Neurology 0915-162016

35

Question 1

bull The most likely semicircular canal to be affected in

BPPV is

ndash 1) superior

ndash 2) lateral

ndash 3) posterior

ndash 4) combined

Answer 3 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

36

Acute Vestibular Syndrome

bull Rapid unilateral injury to either peripheral or central

vestibular structures produces prolonged vertigo

(days to weeks)

bull Severe vertigo nausea and vomiting spontaneous

nystagmus and postural instability

Sixth Annual Intensive Update in Neurology 0915-162016

37

Acute Vestibular Syndrome

bull 25 of patients with risk factors who present with isolated severe vertigo nystagmus and postural instability in the ER have an acute infarction of the inferior cerebellum (AICA PICA) Central imaging is suggested (Baloh 1998 NEJM)

ndash HTN diabetes smoking age gt65 Afib valvular heart disease occlusive vascular disease

Sixth Annual Intensive Update in Neurology 0915-162016

38

HINTS test

bull Head Impulse

bull Nystagmus

bull Test of Skew

ndash More sensitive than MRI in the diagnosis of acute stroke in

patients with acute vestibular syndrome with at least one risk

factor (Kattah J et al Stroke 2009)

Sixth Annual Intensive Update in Neurology 0915-162016

39

Head Impulse Test

bull No special equipment needed

bull Examiner stands in front of seated patient and

randomly moves head left and right Patient is asked to

focus on examinerrsquos nose

bull Rapid low amplitude thrust from lateral to straight

ahead causes a compensatory saccade when

performed towards the weak side

bull This finding is a permanent feature of unilateral

vestibular loss

Sixth Annual Intensive Update in Neurology 0915-162016

40

Head Impulse Test

Sixth Annual Intensive Update in Neurology 0915-162016

41

Head CT ndash Academy of Emergency Medicine 2013

bull The clinical value of head CT in isolated

dizzinessvertigo without any associated neurological

symptoms is very low

bull Less than 1 of head CTs ordered for dizziness and

vertigo have significant abnormalities and those

patients had severe headache and neurological deficits

in addition to dizziness

bull Forgoing unnecessary emergency head CTs could

save 360 million dollars annually

Sixth Annual Intensive Update in Neurology 0915-162016

42

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Sixth Annual Intensive Update in Neurology 0915-162016

43

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Answer 2 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

44

Acute Vestibular Syndrome

bull Usually peripheral and can be associated with

hearing loss (labyrinthitis)

bull Timely diagnosis improves recovery (ASAP

prednisone 1mgkgday for ten days and taper 10

mgday ndash Strupp M 2004 NEJM)

bull Avoid vestibular suppressants after 3 days and begin

vestibular rehabilitation to hasten compensation

Sixth Annual Intensive Update in Neurology 0915-162016

45

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

46

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Answer 5 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

47

Menierersquos syndrome

bull Fluctuating low frequency hearing loss

bull Tinnitus andor aural fullness

bull Vertigo lasting hours

Sixth Annual Intensive Update in Neurology 0915-162016

48

Normal

Sixth Annual Intensive Update in Neurology 0915-162016

49

Hydrops

Sixth Annual Intensive Update in Neurology 0915-162016

50

Menierersquos syndrome

ndash Diagnosis- Exclusion (RO acoustic)

ndash 23 of Menierersquos patients will improve spontaneously

ndash Treatment-1500 mgday low sodium triamterene375-

hydrochlorothiazide 25 vestibular suppressants (lorazepam

1 mg tablet sublingual Q 8 prn attacks) off label use

Sixth Annual Intensive Update in Neurology 0915-162016

51

Menierersquos syndrome ndash intratympanic steroids

ndash A newer treatment option for those failing medical management

ndash 90 response rate (Boleus-Aguirre MS Otology Neurotology

2008)

ndash Outcomes data confirm excellent clinical response in 3941

Menierersquos patients treated with intratympanic steroids in 2008

Sixth Annual Intensive Update in Neurology 0915-162016

52

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

53

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Answer 5 See references at end

Sixth Annual Intensive Update in Neurology 0915-162016

54

Superior Semicircular Canal Dehiscence (SSCD)

bull Sound andor pressure induced oscillopsia

bull CT reformatted in the plane of the superior canals

shows dehiscence of overlying bone

bull Low frequency ldquoconductive hyperacusisrdquo with elevated

bone thresholds normal reflexes and a conductive loss

Sixth Annual Intensive Update in Neurology 0915-162016

55

SSCD

bull Positive middle ear pressure or loud sound stimulates ampullofugal endolymph flow -canal activation

bull Eye movements are tonic upwards with ipsilateral intorsion

Sixth Annual Intensive Update in Neurology 0915-162016

56

SSCD

bull Valsalva against a closed glottis or jugular compression causes increased intracranial pressure and ampullopetal endolymph flow -canal inhibition

bull Eye movements are tonic downwards with ipsilateral extorsion

Sixth Annual Intensive Update in Neurology 0915-162016

57

Reconstructed left superior semicircular canal

Sixth Annual Intensive Update in Neurology 0915-162016

58

Sixth Annual Intensive Update in Neurology 0915-162016

59

SCHEMATIC DRAWING OF AN OTOLITHIC MACULA

Sixth Annual Intensive Update in Neurology 0915-162016

60

MACULAE OF THE UTRICLESACCULE

Sixth Annual Intensive Update in Neurology 0915-162016

61

HAIR CELLS

Sixth Annual Intensive Update in Neurology 0915-162016

62

SCANNING ELECTRON MICROGRAPH OF OTOCONIA

Sixth Annual Intensive Update in Neurology 0915-162016

63

Ocular VEMP

bull Response to loud clicks (80-110 dB) or forehead tap (Halmagyi and Curthoys 2003)

bull Contralateral oculomotor nucleus (CN III)

bull Inferior oblique muscle contraction (8 msec) detected by 5sec event triggered averaging

bull Noninverting electrode inferior to eye

bull Inverting below non-inverting electrode

bull Ground to forehead

bull Normal subjects have very low response

Sixth Annual Intensive Update in Neurology 0915-162016

64

Clinical applications

bull The o-VEMP is a sensitive test of otolithutricular

function

bull Complements vestibular test procedures that assess

semicircular canals

bull Abnormally robust responses are associated with third

window abnormalities such as semicircular canal

dehiscence

bull Serves as an excellent screening test for semicircular

canal dehiscence

Sixth Annual Intensive Update in Neurology 0915-162016

65

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Sixth Annual Intensive Update in Neurology 0915-162016

66

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Answer 1 References at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

67

Enlarged vestibular aqueduct

bull Axial temporal bone CT showing right temporal bone with enlarged vestibular aqueduct (arrow)

bull Vestibular symptoms accompany progressive sensorineural hearing loss in 4-50 of patients in selected series

Sixth Annual Intensive Update in Neurology 0915-162016

68

Migraine

bull Family or personal history of migraine

bull 25 of migraine patients experience spontaneous vertigo (Baloh 1997)

bull Neuhauser criteria(2001) have been used to construct structured diagnostic interviews (Furman 2003)

bull Not always associated with headache

bull Motion sensitivity

bull Medication responsive

Sixth Annual Intensive Update in Neurology 0915-162016

69

ICHD-III beta Criteria for Vestibular Migraine

bull A At least five attacks fulfilling criteria C and D

bull B A current or past history of 11 migraine without aura or 12 migraine with aura

bull C Vestibular symptoms of moderate or severe intensity lasting between 5 minutes and 72 hours

bull D At least 50 associated with one of the following migrainous features

ndash 1 Headaches

ndash 2 Photophobia and phonophobia

ndash 3 Visual Aura

bull E Not better accounted for by another vestibular disorder

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 3: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

3

Objectives

bull Differentiate nystagmus of benign paroxysmal

positional vertigo canal variants

bull Discuss benefits of steroids in acute vestibular

neuritis

bull Review efficacy of intratympanic therapies in

Menierersquos syndrome

bull Describe symptoms of superior semicircular

canal dehiscence

bull Summarize evidence for acute vestibular

syndrome evaluation

Sixth Annual Intensive Update in Neurology 0915-162016

4

Dizziness

bull Most common complaint over age 75

bull 8 million annual US visits

bull Chronic dizziness (gt 2 weeks) affects 16 of self-

reported US population

bull 354 of US adults aged 40 and older have vestibular

dysfunction (National Health and Nutrition Examination

Survey 2001-2004Arch Inter Med 169 (10) 938-44

2009)

Sixth Annual Intensive Update in Neurology 0915-162016

5

History

bull 70 of dizzy patients can be diagnosed with a careful

history (Gufoni 2005)

bull Equilibrium is an unconscious sensation Few

descriptions exist to describe its absence

Sixth Annual Intensive Update in Neurology 0915-162016

6

History

Onset ndash detailed description of first episode and most

recent episode

ndash Character

ndash Frequency

ndash Duration (vertigo andor milder symptoms)

ndash Associated hearing loss or tinnitus

ndash Provoking factors (noise pressure changes position change)

Sixth Annual Intensive Update in Neurology 0915-162016

7

Neuro-otology Physical Exam

bull Otologic ndash check hearing and rule out active infection or

cholesteatoma

bull Oculomotor- saccade pursuit in vertical and horizontal

planes

bull Nystagmus ndash spontaneous gaze evoked and

positionalpositioning testing (best observed using

Frenzel lenses)

bull Special testing ndash head thrust head shake

Sixth Annual Intensive Update in Neurology 0915-162016

8

Peripheral Nystagmus

bull Jerk nystagmus (slow

and fast phase)

bull Direction fixed

bull Generally beats away

from affected ear

bull Worse in the

direction of gaze that

is towards the fast

phase

Sixth Annual Intensive Update in Neurology 0915-162016

9

Benign Paroxysmal Positional Vertigo (BPPV)

bull Vertigo of sudden onset and brief duration provoked by changes in head positionndash Lying down

ndash Rolling over in bed

ndash Bending over

ndash Looking up

ndash Washing hair in shower

ndash Dentist or beauty parlor

Sixth Annual Intensive Update in Neurology 0915-162016

10

Right Posterior BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

11

IncidencePrevalence of BPPV

bull Most common referred diagnosis in tertiary centers

bull 9 of randomly selected community dwelling elderly

(Oghalai JS et al 2000)

bull Incidence increases 38 with each decade of life

(Froehling 1991)

Sixth Annual Intensive Update in Neurology 0915-162016

12

Benign Positional Vertigo (BPPV)

bull Diagnosed with lateral supine head turns and Dix-

Hallpike positioning

ndash Latency

ndash Duration

ndash Fatigue

ndash Habituation

Sixth Annual Intensive Update in Neurology 0915-162016

13

DHT - Sitting

Sixth Annual Intensive Update in Neurology 0915-162016

14

DHT - HHR Orientation

Sixth Annual Intensive Update in Neurology 0915-162016

15

Dix-Hallpike to the Right

Sixth Annual Intensive Update in Neurology 0915-162016

16

Right posterior BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

17

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

18

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

19

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

20

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

21

Canalith Repositioning

bull R posterior

BPPV

CPT 95992

Sixth Annual Intensive Update in Neurology 0915-162016

22

Posterior semicircular canalith repositioning

Sixth Annual Intensive Update in Neurology 0915-162016

23

Supine Positional Tests

Sixth Annual Intensive Update in Neurology 0915-162016

24

Lateral SCC-BPPV

bull Short latency horizontal nystagmus provoked by supine bilateral head turns with prolonged duration and poor fatigability

bull Uncommon (2-15 of total BPPV)

bull Two formsndash Geotropic ndash beating towards undermost ear

ndash Apogeotropic ndash beating away from undermost ear

Sixth Annual Intensive Update in Neurology 0915-162016

25

Geotropic Lateral Canal BPPV

bull Patient is positioned

first to the right lateral

position ndash nystagmus

beats right

bull Patient is then

positioned to the left

lateral position and

nystagmus reverses

and beats left

Sixth Annual Intensive Update in Neurology 0915-162016

26

Left Geotropic Lateral Semicircular Canal BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

27

Repositioning Maneuvers for Geotropic Lateral Semicircular Canal (LSC) BPPV

bull Roll maneuver (Lempert Baloh)

ndash Patient rolls in 90 degree increments towards the good side

completely rolling over R LSC-BPPV repositioning shown

Sixth Annual Intensive Update in Neurology 0915-162016

28

Repositioning Maneuvers for Geotropic LSC BPPV

bull Gufoni maneuver

ndash Patient lies quickly onto good side and turns face-down to

floor for two minutes

Sixth Annual Intensive Update in Neurology 0915-162016

29

Left Apogeotropic LSC BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

30

Nystagmus observed During Repositioning

bull Nystagmus should remain in the same torsional

direction as seen on DHT throughout the treatment of

posterior BPPV

bull Reversal of nystagmus direction suggests the particle

has fallen back into the canal and predicts failure

bull In Lateral BPPV nystagmus should beat towards the

good ear

Sixth Annual Intensive Update in Neurology 0915-162016

31

Posterior to Lateral canal conversion

Sixth Annual Intensive Update in Neurology 0915-162016

32

R Posterior to Lateral Canal conversion - geotropic

Sixth Annual Intensive Update in Neurology 0915-162016

33

BPPV Recurrence

bull Recurrence is common (15yr)

bull Otoconial adherence or mineralization demineralization

abnormalities may contribute to recurrence

bull Home canalith repositioning is effective (Radke 2004)

Sixth Annual Intensive Update in Neurology 0915-162016

34

Question 1

bull The most likely semicircular canal to be affected in

BPPV is

ndash 1) superior

ndash 2) lateral

ndash 3) posterior

ndash 4) combined

Sixth Annual Intensive Update in Neurology 0915-162016

35

Question 1

bull The most likely semicircular canal to be affected in

BPPV is

ndash 1) superior

ndash 2) lateral

ndash 3) posterior

ndash 4) combined

Answer 3 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

36

Acute Vestibular Syndrome

bull Rapid unilateral injury to either peripheral or central

vestibular structures produces prolonged vertigo

(days to weeks)

bull Severe vertigo nausea and vomiting spontaneous

nystagmus and postural instability

Sixth Annual Intensive Update in Neurology 0915-162016

37

Acute Vestibular Syndrome

bull 25 of patients with risk factors who present with isolated severe vertigo nystagmus and postural instability in the ER have an acute infarction of the inferior cerebellum (AICA PICA) Central imaging is suggested (Baloh 1998 NEJM)

ndash HTN diabetes smoking age gt65 Afib valvular heart disease occlusive vascular disease

Sixth Annual Intensive Update in Neurology 0915-162016

38

HINTS test

bull Head Impulse

bull Nystagmus

bull Test of Skew

ndash More sensitive than MRI in the diagnosis of acute stroke in

patients with acute vestibular syndrome with at least one risk

factor (Kattah J et al Stroke 2009)

Sixth Annual Intensive Update in Neurology 0915-162016

39

Head Impulse Test

bull No special equipment needed

bull Examiner stands in front of seated patient and

randomly moves head left and right Patient is asked to

focus on examinerrsquos nose

bull Rapid low amplitude thrust from lateral to straight

ahead causes a compensatory saccade when

performed towards the weak side

bull This finding is a permanent feature of unilateral

vestibular loss

Sixth Annual Intensive Update in Neurology 0915-162016

40

Head Impulse Test

Sixth Annual Intensive Update in Neurology 0915-162016

41

Head CT ndash Academy of Emergency Medicine 2013

bull The clinical value of head CT in isolated

dizzinessvertigo without any associated neurological

symptoms is very low

bull Less than 1 of head CTs ordered for dizziness and

vertigo have significant abnormalities and those

patients had severe headache and neurological deficits

in addition to dizziness

bull Forgoing unnecessary emergency head CTs could

save 360 million dollars annually

Sixth Annual Intensive Update in Neurology 0915-162016

42

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Sixth Annual Intensive Update in Neurology 0915-162016

43

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Answer 2 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

44

Acute Vestibular Syndrome

bull Usually peripheral and can be associated with

hearing loss (labyrinthitis)

bull Timely diagnosis improves recovery (ASAP

prednisone 1mgkgday for ten days and taper 10

mgday ndash Strupp M 2004 NEJM)

bull Avoid vestibular suppressants after 3 days and begin

vestibular rehabilitation to hasten compensation

Sixth Annual Intensive Update in Neurology 0915-162016

45

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

46

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Answer 5 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

47

Menierersquos syndrome

bull Fluctuating low frequency hearing loss

bull Tinnitus andor aural fullness

bull Vertigo lasting hours

Sixth Annual Intensive Update in Neurology 0915-162016

48

Normal

Sixth Annual Intensive Update in Neurology 0915-162016

49

Hydrops

Sixth Annual Intensive Update in Neurology 0915-162016

50

Menierersquos syndrome

ndash Diagnosis- Exclusion (RO acoustic)

ndash 23 of Menierersquos patients will improve spontaneously

ndash Treatment-1500 mgday low sodium triamterene375-

hydrochlorothiazide 25 vestibular suppressants (lorazepam

1 mg tablet sublingual Q 8 prn attacks) off label use

Sixth Annual Intensive Update in Neurology 0915-162016

51

Menierersquos syndrome ndash intratympanic steroids

ndash A newer treatment option for those failing medical management

ndash 90 response rate (Boleus-Aguirre MS Otology Neurotology

2008)

ndash Outcomes data confirm excellent clinical response in 3941

Menierersquos patients treated with intratympanic steroids in 2008

Sixth Annual Intensive Update in Neurology 0915-162016

52

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

53

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Answer 5 See references at end

Sixth Annual Intensive Update in Neurology 0915-162016

54

Superior Semicircular Canal Dehiscence (SSCD)

bull Sound andor pressure induced oscillopsia

bull CT reformatted in the plane of the superior canals

shows dehiscence of overlying bone

bull Low frequency ldquoconductive hyperacusisrdquo with elevated

bone thresholds normal reflexes and a conductive loss

Sixth Annual Intensive Update in Neurology 0915-162016

55

SSCD

bull Positive middle ear pressure or loud sound stimulates ampullofugal endolymph flow -canal activation

bull Eye movements are tonic upwards with ipsilateral intorsion

Sixth Annual Intensive Update in Neurology 0915-162016

56

SSCD

bull Valsalva against a closed glottis or jugular compression causes increased intracranial pressure and ampullopetal endolymph flow -canal inhibition

bull Eye movements are tonic downwards with ipsilateral extorsion

Sixth Annual Intensive Update in Neurology 0915-162016

57

Reconstructed left superior semicircular canal

Sixth Annual Intensive Update in Neurology 0915-162016

58

Sixth Annual Intensive Update in Neurology 0915-162016

59

SCHEMATIC DRAWING OF AN OTOLITHIC MACULA

Sixth Annual Intensive Update in Neurology 0915-162016

60

MACULAE OF THE UTRICLESACCULE

Sixth Annual Intensive Update in Neurology 0915-162016

61

HAIR CELLS

Sixth Annual Intensive Update in Neurology 0915-162016

62

SCANNING ELECTRON MICROGRAPH OF OTOCONIA

Sixth Annual Intensive Update in Neurology 0915-162016

63

Ocular VEMP

bull Response to loud clicks (80-110 dB) or forehead tap (Halmagyi and Curthoys 2003)

bull Contralateral oculomotor nucleus (CN III)

bull Inferior oblique muscle contraction (8 msec) detected by 5sec event triggered averaging

bull Noninverting electrode inferior to eye

bull Inverting below non-inverting electrode

bull Ground to forehead

bull Normal subjects have very low response

Sixth Annual Intensive Update in Neurology 0915-162016

64

Clinical applications

bull The o-VEMP is a sensitive test of otolithutricular

function

bull Complements vestibular test procedures that assess

semicircular canals

bull Abnormally robust responses are associated with third

window abnormalities such as semicircular canal

dehiscence

bull Serves as an excellent screening test for semicircular

canal dehiscence

Sixth Annual Intensive Update in Neurology 0915-162016

65

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Sixth Annual Intensive Update in Neurology 0915-162016

66

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Answer 1 References at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

67

Enlarged vestibular aqueduct

bull Axial temporal bone CT showing right temporal bone with enlarged vestibular aqueduct (arrow)

bull Vestibular symptoms accompany progressive sensorineural hearing loss in 4-50 of patients in selected series

Sixth Annual Intensive Update in Neurology 0915-162016

68

Migraine

bull Family or personal history of migraine

bull 25 of migraine patients experience spontaneous vertigo (Baloh 1997)

bull Neuhauser criteria(2001) have been used to construct structured diagnostic interviews (Furman 2003)

bull Not always associated with headache

bull Motion sensitivity

bull Medication responsive

Sixth Annual Intensive Update in Neurology 0915-162016

69

ICHD-III beta Criteria for Vestibular Migraine

bull A At least five attacks fulfilling criteria C and D

bull B A current or past history of 11 migraine without aura or 12 migraine with aura

bull C Vestibular symptoms of moderate or severe intensity lasting between 5 minutes and 72 hours

bull D At least 50 associated with one of the following migrainous features

ndash 1 Headaches

ndash 2 Photophobia and phonophobia

ndash 3 Visual Aura

bull E Not better accounted for by another vestibular disorder

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 4: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

4

Dizziness

bull Most common complaint over age 75

bull 8 million annual US visits

bull Chronic dizziness (gt 2 weeks) affects 16 of self-

reported US population

bull 354 of US adults aged 40 and older have vestibular

dysfunction (National Health and Nutrition Examination

Survey 2001-2004Arch Inter Med 169 (10) 938-44

2009)

Sixth Annual Intensive Update in Neurology 0915-162016

5

History

bull 70 of dizzy patients can be diagnosed with a careful

history (Gufoni 2005)

bull Equilibrium is an unconscious sensation Few

descriptions exist to describe its absence

Sixth Annual Intensive Update in Neurology 0915-162016

6

History

Onset ndash detailed description of first episode and most

recent episode

ndash Character

ndash Frequency

ndash Duration (vertigo andor milder symptoms)

ndash Associated hearing loss or tinnitus

ndash Provoking factors (noise pressure changes position change)

Sixth Annual Intensive Update in Neurology 0915-162016

7

Neuro-otology Physical Exam

bull Otologic ndash check hearing and rule out active infection or

cholesteatoma

bull Oculomotor- saccade pursuit in vertical and horizontal

planes

bull Nystagmus ndash spontaneous gaze evoked and

positionalpositioning testing (best observed using

Frenzel lenses)

bull Special testing ndash head thrust head shake

Sixth Annual Intensive Update in Neurology 0915-162016

8

Peripheral Nystagmus

bull Jerk nystagmus (slow

and fast phase)

bull Direction fixed

bull Generally beats away

from affected ear

bull Worse in the

direction of gaze that

is towards the fast

phase

Sixth Annual Intensive Update in Neurology 0915-162016

9

Benign Paroxysmal Positional Vertigo (BPPV)

bull Vertigo of sudden onset and brief duration provoked by changes in head positionndash Lying down

ndash Rolling over in bed

ndash Bending over

ndash Looking up

ndash Washing hair in shower

ndash Dentist or beauty parlor

Sixth Annual Intensive Update in Neurology 0915-162016

10

Right Posterior BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

11

IncidencePrevalence of BPPV

bull Most common referred diagnosis in tertiary centers

bull 9 of randomly selected community dwelling elderly

(Oghalai JS et al 2000)

bull Incidence increases 38 with each decade of life

(Froehling 1991)

Sixth Annual Intensive Update in Neurology 0915-162016

12

Benign Positional Vertigo (BPPV)

bull Diagnosed with lateral supine head turns and Dix-

Hallpike positioning

ndash Latency

ndash Duration

ndash Fatigue

ndash Habituation

Sixth Annual Intensive Update in Neurology 0915-162016

13

DHT - Sitting

Sixth Annual Intensive Update in Neurology 0915-162016

14

DHT - HHR Orientation

Sixth Annual Intensive Update in Neurology 0915-162016

15

Dix-Hallpike to the Right

Sixth Annual Intensive Update in Neurology 0915-162016

16

Right posterior BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

17

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

18

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

19

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

20

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

21

Canalith Repositioning

bull R posterior

BPPV

CPT 95992

Sixth Annual Intensive Update in Neurology 0915-162016

22

Posterior semicircular canalith repositioning

Sixth Annual Intensive Update in Neurology 0915-162016

23

Supine Positional Tests

Sixth Annual Intensive Update in Neurology 0915-162016

24

Lateral SCC-BPPV

bull Short latency horizontal nystagmus provoked by supine bilateral head turns with prolonged duration and poor fatigability

bull Uncommon (2-15 of total BPPV)

bull Two formsndash Geotropic ndash beating towards undermost ear

ndash Apogeotropic ndash beating away from undermost ear

Sixth Annual Intensive Update in Neurology 0915-162016

25

Geotropic Lateral Canal BPPV

bull Patient is positioned

first to the right lateral

position ndash nystagmus

beats right

bull Patient is then

positioned to the left

lateral position and

nystagmus reverses

and beats left

Sixth Annual Intensive Update in Neurology 0915-162016

26

Left Geotropic Lateral Semicircular Canal BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

27

Repositioning Maneuvers for Geotropic Lateral Semicircular Canal (LSC) BPPV

bull Roll maneuver (Lempert Baloh)

ndash Patient rolls in 90 degree increments towards the good side

completely rolling over R LSC-BPPV repositioning shown

Sixth Annual Intensive Update in Neurology 0915-162016

28

Repositioning Maneuvers for Geotropic LSC BPPV

bull Gufoni maneuver

ndash Patient lies quickly onto good side and turns face-down to

floor for two minutes

Sixth Annual Intensive Update in Neurology 0915-162016

29

Left Apogeotropic LSC BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

30

Nystagmus observed During Repositioning

bull Nystagmus should remain in the same torsional

direction as seen on DHT throughout the treatment of

posterior BPPV

bull Reversal of nystagmus direction suggests the particle

has fallen back into the canal and predicts failure

bull In Lateral BPPV nystagmus should beat towards the

good ear

Sixth Annual Intensive Update in Neurology 0915-162016

31

Posterior to Lateral canal conversion

Sixth Annual Intensive Update in Neurology 0915-162016

32

R Posterior to Lateral Canal conversion - geotropic

Sixth Annual Intensive Update in Neurology 0915-162016

33

BPPV Recurrence

bull Recurrence is common (15yr)

bull Otoconial adherence or mineralization demineralization

abnormalities may contribute to recurrence

bull Home canalith repositioning is effective (Radke 2004)

Sixth Annual Intensive Update in Neurology 0915-162016

34

Question 1

bull The most likely semicircular canal to be affected in

BPPV is

ndash 1) superior

ndash 2) lateral

ndash 3) posterior

ndash 4) combined

Sixth Annual Intensive Update in Neurology 0915-162016

35

Question 1

bull The most likely semicircular canal to be affected in

BPPV is

ndash 1) superior

ndash 2) lateral

ndash 3) posterior

ndash 4) combined

Answer 3 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

36

Acute Vestibular Syndrome

bull Rapid unilateral injury to either peripheral or central

vestibular structures produces prolonged vertigo

(days to weeks)

bull Severe vertigo nausea and vomiting spontaneous

nystagmus and postural instability

Sixth Annual Intensive Update in Neurology 0915-162016

37

Acute Vestibular Syndrome

bull 25 of patients with risk factors who present with isolated severe vertigo nystagmus and postural instability in the ER have an acute infarction of the inferior cerebellum (AICA PICA) Central imaging is suggested (Baloh 1998 NEJM)

ndash HTN diabetes smoking age gt65 Afib valvular heart disease occlusive vascular disease

Sixth Annual Intensive Update in Neurology 0915-162016

38

HINTS test

bull Head Impulse

bull Nystagmus

bull Test of Skew

ndash More sensitive than MRI in the diagnosis of acute stroke in

patients with acute vestibular syndrome with at least one risk

factor (Kattah J et al Stroke 2009)

Sixth Annual Intensive Update in Neurology 0915-162016

39

Head Impulse Test

bull No special equipment needed

bull Examiner stands in front of seated patient and

randomly moves head left and right Patient is asked to

focus on examinerrsquos nose

bull Rapid low amplitude thrust from lateral to straight

ahead causes a compensatory saccade when

performed towards the weak side

bull This finding is a permanent feature of unilateral

vestibular loss

Sixth Annual Intensive Update in Neurology 0915-162016

40

Head Impulse Test

Sixth Annual Intensive Update in Neurology 0915-162016

41

Head CT ndash Academy of Emergency Medicine 2013

bull The clinical value of head CT in isolated

dizzinessvertigo without any associated neurological

symptoms is very low

bull Less than 1 of head CTs ordered for dizziness and

vertigo have significant abnormalities and those

patients had severe headache and neurological deficits

in addition to dizziness

bull Forgoing unnecessary emergency head CTs could

save 360 million dollars annually

Sixth Annual Intensive Update in Neurology 0915-162016

42

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Sixth Annual Intensive Update in Neurology 0915-162016

43

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Answer 2 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

44

Acute Vestibular Syndrome

bull Usually peripheral and can be associated with

hearing loss (labyrinthitis)

bull Timely diagnosis improves recovery (ASAP

prednisone 1mgkgday for ten days and taper 10

mgday ndash Strupp M 2004 NEJM)

bull Avoid vestibular suppressants after 3 days and begin

vestibular rehabilitation to hasten compensation

Sixth Annual Intensive Update in Neurology 0915-162016

45

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

46

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Answer 5 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

47

Menierersquos syndrome

bull Fluctuating low frequency hearing loss

bull Tinnitus andor aural fullness

bull Vertigo lasting hours

Sixth Annual Intensive Update in Neurology 0915-162016

48

Normal

Sixth Annual Intensive Update in Neurology 0915-162016

49

Hydrops

Sixth Annual Intensive Update in Neurology 0915-162016

50

Menierersquos syndrome

ndash Diagnosis- Exclusion (RO acoustic)

ndash 23 of Menierersquos patients will improve spontaneously

ndash Treatment-1500 mgday low sodium triamterene375-

hydrochlorothiazide 25 vestibular suppressants (lorazepam

1 mg tablet sublingual Q 8 prn attacks) off label use

Sixth Annual Intensive Update in Neurology 0915-162016

51

Menierersquos syndrome ndash intratympanic steroids

ndash A newer treatment option for those failing medical management

ndash 90 response rate (Boleus-Aguirre MS Otology Neurotology

2008)

ndash Outcomes data confirm excellent clinical response in 3941

Menierersquos patients treated with intratympanic steroids in 2008

Sixth Annual Intensive Update in Neurology 0915-162016

52

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

53

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Answer 5 See references at end

Sixth Annual Intensive Update in Neurology 0915-162016

54

Superior Semicircular Canal Dehiscence (SSCD)

bull Sound andor pressure induced oscillopsia

bull CT reformatted in the plane of the superior canals

shows dehiscence of overlying bone

bull Low frequency ldquoconductive hyperacusisrdquo with elevated

bone thresholds normal reflexes and a conductive loss

Sixth Annual Intensive Update in Neurology 0915-162016

55

SSCD

bull Positive middle ear pressure or loud sound stimulates ampullofugal endolymph flow -canal activation

bull Eye movements are tonic upwards with ipsilateral intorsion

Sixth Annual Intensive Update in Neurology 0915-162016

56

SSCD

bull Valsalva against a closed glottis or jugular compression causes increased intracranial pressure and ampullopetal endolymph flow -canal inhibition

bull Eye movements are tonic downwards with ipsilateral extorsion

Sixth Annual Intensive Update in Neurology 0915-162016

57

Reconstructed left superior semicircular canal

Sixth Annual Intensive Update in Neurology 0915-162016

58

Sixth Annual Intensive Update in Neurology 0915-162016

59

SCHEMATIC DRAWING OF AN OTOLITHIC MACULA

Sixth Annual Intensive Update in Neurology 0915-162016

60

MACULAE OF THE UTRICLESACCULE

Sixth Annual Intensive Update in Neurology 0915-162016

61

HAIR CELLS

Sixth Annual Intensive Update in Neurology 0915-162016

62

SCANNING ELECTRON MICROGRAPH OF OTOCONIA

Sixth Annual Intensive Update in Neurology 0915-162016

63

Ocular VEMP

bull Response to loud clicks (80-110 dB) or forehead tap (Halmagyi and Curthoys 2003)

bull Contralateral oculomotor nucleus (CN III)

bull Inferior oblique muscle contraction (8 msec) detected by 5sec event triggered averaging

bull Noninverting electrode inferior to eye

bull Inverting below non-inverting electrode

bull Ground to forehead

bull Normal subjects have very low response

Sixth Annual Intensive Update in Neurology 0915-162016

64

Clinical applications

bull The o-VEMP is a sensitive test of otolithutricular

function

bull Complements vestibular test procedures that assess

semicircular canals

bull Abnormally robust responses are associated with third

window abnormalities such as semicircular canal

dehiscence

bull Serves as an excellent screening test for semicircular

canal dehiscence

Sixth Annual Intensive Update in Neurology 0915-162016

65

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Sixth Annual Intensive Update in Neurology 0915-162016

66

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Answer 1 References at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

67

Enlarged vestibular aqueduct

bull Axial temporal bone CT showing right temporal bone with enlarged vestibular aqueduct (arrow)

bull Vestibular symptoms accompany progressive sensorineural hearing loss in 4-50 of patients in selected series

Sixth Annual Intensive Update in Neurology 0915-162016

68

Migraine

bull Family or personal history of migraine

bull 25 of migraine patients experience spontaneous vertigo (Baloh 1997)

bull Neuhauser criteria(2001) have been used to construct structured diagnostic interviews (Furman 2003)

bull Not always associated with headache

bull Motion sensitivity

bull Medication responsive

Sixth Annual Intensive Update in Neurology 0915-162016

69

ICHD-III beta Criteria for Vestibular Migraine

bull A At least five attacks fulfilling criteria C and D

bull B A current or past history of 11 migraine without aura or 12 migraine with aura

bull C Vestibular symptoms of moderate or severe intensity lasting between 5 minutes and 72 hours

bull D At least 50 associated with one of the following migrainous features

ndash 1 Headaches

ndash 2 Photophobia and phonophobia

ndash 3 Visual Aura

bull E Not better accounted for by another vestibular disorder

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 5: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

5

History

bull 70 of dizzy patients can be diagnosed with a careful

history (Gufoni 2005)

bull Equilibrium is an unconscious sensation Few

descriptions exist to describe its absence

Sixth Annual Intensive Update in Neurology 0915-162016

6

History

Onset ndash detailed description of first episode and most

recent episode

ndash Character

ndash Frequency

ndash Duration (vertigo andor milder symptoms)

ndash Associated hearing loss or tinnitus

ndash Provoking factors (noise pressure changes position change)

Sixth Annual Intensive Update in Neurology 0915-162016

7

Neuro-otology Physical Exam

bull Otologic ndash check hearing and rule out active infection or

cholesteatoma

bull Oculomotor- saccade pursuit in vertical and horizontal

planes

bull Nystagmus ndash spontaneous gaze evoked and

positionalpositioning testing (best observed using

Frenzel lenses)

bull Special testing ndash head thrust head shake

Sixth Annual Intensive Update in Neurology 0915-162016

8

Peripheral Nystagmus

bull Jerk nystagmus (slow

and fast phase)

bull Direction fixed

bull Generally beats away

from affected ear

bull Worse in the

direction of gaze that

is towards the fast

phase

Sixth Annual Intensive Update in Neurology 0915-162016

9

Benign Paroxysmal Positional Vertigo (BPPV)

bull Vertigo of sudden onset and brief duration provoked by changes in head positionndash Lying down

ndash Rolling over in bed

ndash Bending over

ndash Looking up

ndash Washing hair in shower

ndash Dentist or beauty parlor

Sixth Annual Intensive Update in Neurology 0915-162016

10

Right Posterior BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

11

IncidencePrevalence of BPPV

bull Most common referred diagnosis in tertiary centers

bull 9 of randomly selected community dwelling elderly

(Oghalai JS et al 2000)

bull Incidence increases 38 with each decade of life

(Froehling 1991)

Sixth Annual Intensive Update in Neurology 0915-162016

12

Benign Positional Vertigo (BPPV)

bull Diagnosed with lateral supine head turns and Dix-

Hallpike positioning

ndash Latency

ndash Duration

ndash Fatigue

ndash Habituation

Sixth Annual Intensive Update in Neurology 0915-162016

13

DHT - Sitting

Sixth Annual Intensive Update in Neurology 0915-162016

14

DHT - HHR Orientation

Sixth Annual Intensive Update in Neurology 0915-162016

15

Dix-Hallpike to the Right

Sixth Annual Intensive Update in Neurology 0915-162016

16

Right posterior BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

17

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

18

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

19

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

20

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

21

Canalith Repositioning

bull R posterior

BPPV

CPT 95992

Sixth Annual Intensive Update in Neurology 0915-162016

22

Posterior semicircular canalith repositioning

Sixth Annual Intensive Update in Neurology 0915-162016

23

Supine Positional Tests

Sixth Annual Intensive Update in Neurology 0915-162016

24

Lateral SCC-BPPV

bull Short latency horizontal nystagmus provoked by supine bilateral head turns with prolonged duration and poor fatigability

bull Uncommon (2-15 of total BPPV)

bull Two formsndash Geotropic ndash beating towards undermost ear

ndash Apogeotropic ndash beating away from undermost ear

Sixth Annual Intensive Update in Neurology 0915-162016

25

Geotropic Lateral Canal BPPV

bull Patient is positioned

first to the right lateral

position ndash nystagmus

beats right

bull Patient is then

positioned to the left

lateral position and

nystagmus reverses

and beats left

Sixth Annual Intensive Update in Neurology 0915-162016

26

Left Geotropic Lateral Semicircular Canal BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

27

Repositioning Maneuvers for Geotropic Lateral Semicircular Canal (LSC) BPPV

bull Roll maneuver (Lempert Baloh)

ndash Patient rolls in 90 degree increments towards the good side

completely rolling over R LSC-BPPV repositioning shown

Sixth Annual Intensive Update in Neurology 0915-162016

28

Repositioning Maneuvers for Geotropic LSC BPPV

bull Gufoni maneuver

ndash Patient lies quickly onto good side and turns face-down to

floor for two minutes

Sixth Annual Intensive Update in Neurology 0915-162016

29

Left Apogeotropic LSC BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

30

Nystagmus observed During Repositioning

bull Nystagmus should remain in the same torsional

direction as seen on DHT throughout the treatment of

posterior BPPV

bull Reversal of nystagmus direction suggests the particle

has fallen back into the canal and predicts failure

bull In Lateral BPPV nystagmus should beat towards the

good ear

Sixth Annual Intensive Update in Neurology 0915-162016

31

Posterior to Lateral canal conversion

Sixth Annual Intensive Update in Neurology 0915-162016

32

R Posterior to Lateral Canal conversion - geotropic

Sixth Annual Intensive Update in Neurology 0915-162016

33

BPPV Recurrence

bull Recurrence is common (15yr)

bull Otoconial adherence or mineralization demineralization

abnormalities may contribute to recurrence

bull Home canalith repositioning is effective (Radke 2004)

Sixth Annual Intensive Update in Neurology 0915-162016

34

Question 1

bull The most likely semicircular canal to be affected in

BPPV is

ndash 1) superior

ndash 2) lateral

ndash 3) posterior

ndash 4) combined

Sixth Annual Intensive Update in Neurology 0915-162016

35

Question 1

bull The most likely semicircular canal to be affected in

BPPV is

ndash 1) superior

ndash 2) lateral

ndash 3) posterior

ndash 4) combined

Answer 3 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

36

Acute Vestibular Syndrome

bull Rapid unilateral injury to either peripheral or central

vestibular structures produces prolonged vertigo

(days to weeks)

bull Severe vertigo nausea and vomiting spontaneous

nystagmus and postural instability

Sixth Annual Intensive Update in Neurology 0915-162016

37

Acute Vestibular Syndrome

bull 25 of patients with risk factors who present with isolated severe vertigo nystagmus and postural instability in the ER have an acute infarction of the inferior cerebellum (AICA PICA) Central imaging is suggested (Baloh 1998 NEJM)

ndash HTN diabetes smoking age gt65 Afib valvular heart disease occlusive vascular disease

Sixth Annual Intensive Update in Neurology 0915-162016

38

HINTS test

bull Head Impulse

bull Nystagmus

bull Test of Skew

ndash More sensitive than MRI in the diagnosis of acute stroke in

patients with acute vestibular syndrome with at least one risk

factor (Kattah J et al Stroke 2009)

Sixth Annual Intensive Update in Neurology 0915-162016

39

Head Impulse Test

bull No special equipment needed

bull Examiner stands in front of seated patient and

randomly moves head left and right Patient is asked to

focus on examinerrsquos nose

bull Rapid low amplitude thrust from lateral to straight

ahead causes a compensatory saccade when

performed towards the weak side

bull This finding is a permanent feature of unilateral

vestibular loss

Sixth Annual Intensive Update in Neurology 0915-162016

40

Head Impulse Test

Sixth Annual Intensive Update in Neurology 0915-162016

41

Head CT ndash Academy of Emergency Medicine 2013

bull The clinical value of head CT in isolated

dizzinessvertigo without any associated neurological

symptoms is very low

bull Less than 1 of head CTs ordered for dizziness and

vertigo have significant abnormalities and those

patients had severe headache and neurological deficits

in addition to dizziness

bull Forgoing unnecessary emergency head CTs could

save 360 million dollars annually

Sixth Annual Intensive Update in Neurology 0915-162016

42

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Sixth Annual Intensive Update in Neurology 0915-162016

43

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Answer 2 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

44

Acute Vestibular Syndrome

bull Usually peripheral and can be associated with

hearing loss (labyrinthitis)

bull Timely diagnosis improves recovery (ASAP

prednisone 1mgkgday for ten days and taper 10

mgday ndash Strupp M 2004 NEJM)

bull Avoid vestibular suppressants after 3 days and begin

vestibular rehabilitation to hasten compensation

Sixth Annual Intensive Update in Neurology 0915-162016

45

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

46

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Answer 5 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

47

Menierersquos syndrome

bull Fluctuating low frequency hearing loss

bull Tinnitus andor aural fullness

bull Vertigo lasting hours

Sixth Annual Intensive Update in Neurology 0915-162016

48

Normal

Sixth Annual Intensive Update in Neurology 0915-162016

49

Hydrops

Sixth Annual Intensive Update in Neurology 0915-162016

50

Menierersquos syndrome

ndash Diagnosis- Exclusion (RO acoustic)

ndash 23 of Menierersquos patients will improve spontaneously

ndash Treatment-1500 mgday low sodium triamterene375-

hydrochlorothiazide 25 vestibular suppressants (lorazepam

1 mg tablet sublingual Q 8 prn attacks) off label use

Sixth Annual Intensive Update in Neurology 0915-162016

51

Menierersquos syndrome ndash intratympanic steroids

ndash A newer treatment option for those failing medical management

ndash 90 response rate (Boleus-Aguirre MS Otology Neurotology

2008)

ndash Outcomes data confirm excellent clinical response in 3941

Menierersquos patients treated with intratympanic steroids in 2008

Sixth Annual Intensive Update in Neurology 0915-162016

52

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

53

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Answer 5 See references at end

Sixth Annual Intensive Update in Neurology 0915-162016

54

Superior Semicircular Canal Dehiscence (SSCD)

bull Sound andor pressure induced oscillopsia

bull CT reformatted in the plane of the superior canals

shows dehiscence of overlying bone

bull Low frequency ldquoconductive hyperacusisrdquo with elevated

bone thresholds normal reflexes and a conductive loss

Sixth Annual Intensive Update in Neurology 0915-162016

55

SSCD

bull Positive middle ear pressure or loud sound stimulates ampullofugal endolymph flow -canal activation

bull Eye movements are tonic upwards with ipsilateral intorsion

Sixth Annual Intensive Update in Neurology 0915-162016

56

SSCD

bull Valsalva against a closed glottis or jugular compression causes increased intracranial pressure and ampullopetal endolymph flow -canal inhibition

bull Eye movements are tonic downwards with ipsilateral extorsion

Sixth Annual Intensive Update in Neurology 0915-162016

57

Reconstructed left superior semicircular canal

Sixth Annual Intensive Update in Neurology 0915-162016

58

Sixth Annual Intensive Update in Neurology 0915-162016

59

SCHEMATIC DRAWING OF AN OTOLITHIC MACULA

Sixth Annual Intensive Update in Neurology 0915-162016

60

MACULAE OF THE UTRICLESACCULE

Sixth Annual Intensive Update in Neurology 0915-162016

61

HAIR CELLS

Sixth Annual Intensive Update in Neurology 0915-162016

62

SCANNING ELECTRON MICROGRAPH OF OTOCONIA

Sixth Annual Intensive Update in Neurology 0915-162016

63

Ocular VEMP

bull Response to loud clicks (80-110 dB) or forehead tap (Halmagyi and Curthoys 2003)

bull Contralateral oculomotor nucleus (CN III)

bull Inferior oblique muscle contraction (8 msec) detected by 5sec event triggered averaging

bull Noninverting electrode inferior to eye

bull Inverting below non-inverting electrode

bull Ground to forehead

bull Normal subjects have very low response

Sixth Annual Intensive Update in Neurology 0915-162016

64

Clinical applications

bull The o-VEMP is a sensitive test of otolithutricular

function

bull Complements vestibular test procedures that assess

semicircular canals

bull Abnormally robust responses are associated with third

window abnormalities such as semicircular canal

dehiscence

bull Serves as an excellent screening test for semicircular

canal dehiscence

Sixth Annual Intensive Update in Neurology 0915-162016

65

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Sixth Annual Intensive Update in Neurology 0915-162016

66

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Answer 1 References at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

67

Enlarged vestibular aqueduct

bull Axial temporal bone CT showing right temporal bone with enlarged vestibular aqueduct (arrow)

bull Vestibular symptoms accompany progressive sensorineural hearing loss in 4-50 of patients in selected series

Sixth Annual Intensive Update in Neurology 0915-162016

68

Migraine

bull Family or personal history of migraine

bull 25 of migraine patients experience spontaneous vertigo (Baloh 1997)

bull Neuhauser criteria(2001) have been used to construct structured diagnostic interviews (Furman 2003)

bull Not always associated with headache

bull Motion sensitivity

bull Medication responsive

Sixth Annual Intensive Update in Neurology 0915-162016

69

ICHD-III beta Criteria for Vestibular Migraine

bull A At least five attacks fulfilling criteria C and D

bull B A current or past history of 11 migraine without aura or 12 migraine with aura

bull C Vestibular symptoms of moderate or severe intensity lasting between 5 minutes and 72 hours

bull D At least 50 associated with one of the following migrainous features

ndash 1 Headaches

ndash 2 Photophobia and phonophobia

ndash 3 Visual Aura

bull E Not better accounted for by another vestibular disorder

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 6: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

6

History

Onset ndash detailed description of first episode and most

recent episode

ndash Character

ndash Frequency

ndash Duration (vertigo andor milder symptoms)

ndash Associated hearing loss or tinnitus

ndash Provoking factors (noise pressure changes position change)

Sixth Annual Intensive Update in Neurology 0915-162016

7

Neuro-otology Physical Exam

bull Otologic ndash check hearing and rule out active infection or

cholesteatoma

bull Oculomotor- saccade pursuit in vertical and horizontal

planes

bull Nystagmus ndash spontaneous gaze evoked and

positionalpositioning testing (best observed using

Frenzel lenses)

bull Special testing ndash head thrust head shake

Sixth Annual Intensive Update in Neurology 0915-162016

8

Peripheral Nystagmus

bull Jerk nystagmus (slow

and fast phase)

bull Direction fixed

bull Generally beats away

from affected ear

bull Worse in the

direction of gaze that

is towards the fast

phase

Sixth Annual Intensive Update in Neurology 0915-162016

9

Benign Paroxysmal Positional Vertigo (BPPV)

bull Vertigo of sudden onset and brief duration provoked by changes in head positionndash Lying down

ndash Rolling over in bed

ndash Bending over

ndash Looking up

ndash Washing hair in shower

ndash Dentist or beauty parlor

Sixth Annual Intensive Update in Neurology 0915-162016

10

Right Posterior BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

11

IncidencePrevalence of BPPV

bull Most common referred diagnosis in tertiary centers

bull 9 of randomly selected community dwelling elderly

(Oghalai JS et al 2000)

bull Incidence increases 38 with each decade of life

(Froehling 1991)

Sixth Annual Intensive Update in Neurology 0915-162016

12

Benign Positional Vertigo (BPPV)

bull Diagnosed with lateral supine head turns and Dix-

Hallpike positioning

ndash Latency

ndash Duration

ndash Fatigue

ndash Habituation

Sixth Annual Intensive Update in Neurology 0915-162016

13

DHT - Sitting

Sixth Annual Intensive Update in Neurology 0915-162016

14

DHT - HHR Orientation

Sixth Annual Intensive Update in Neurology 0915-162016

15

Dix-Hallpike to the Right

Sixth Annual Intensive Update in Neurology 0915-162016

16

Right posterior BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

17

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

18

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

19

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

20

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

21

Canalith Repositioning

bull R posterior

BPPV

CPT 95992

Sixth Annual Intensive Update in Neurology 0915-162016

22

Posterior semicircular canalith repositioning

Sixth Annual Intensive Update in Neurology 0915-162016

23

Supine Positional Tests

Sixth Annual Intensive Update in Neurology 0915-162016

24

Lateral SCC-BPPV

bull Short latency horizontal nystagmus provoked by supine bilateral head turns with prolonged duration and poor fatigability

bull Uncommon (2-15 of total BPPV)

bull Two formsndash Geotropic ndash beating towards undermost ear

ndash Apogeotropic ndash beating away from undermost ear

Sixth Annual Intensive Update in Neurology 0915-162016

25

Geotropic Lateral Canal BPPV

bull Patient is positioned

first to the right lateral

position ndash nystagmus

beats right

bull Patient is then

positioned to the left

lateral position and

nystagmus reverses

and beats left

Sixth Annual Intensive Update in Neurology 0915-162016

26

Left Geotropic Lateral Semicircular Canal BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

27

Repositioning Maneuvers for Geotropic Lateral Semicircular Canal (LSC) BPPV

bull Roll maneuver (Lempert Baloh)

ndash Patient rolls in 90 degree increments towards the good side

completely rolling over R LSC-BPPV repositioning shown

Sixth Annual Intensive Update in Neurology 0915-162016

28

Repositioning Maneuvers for Geotropic LSC BPPV

bull Gufoni maneuver

ndash Patient lies quickly onto good side and turns face-down to

floor for two minutes

Sixth Annual Intensive Update in Neurology 0915-162016

29

Left Apogeotropic LSC BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

30

Nystagmus observed During Repositioning

bull Nystagmus should remain in the same torsional

direction as seen on DHT throughout the treatment of

posterior BPPV

bull Reversal of nystagmus direction suggests the particle

has fallen back into the canal and predicts failure

bull In Lateral BPPV nystagmus should beat towards the

good ear

Sixth Annual Intensive Update in Neurology 0915-162016

31

Posterior to Lateral canal conversion

Sixth Annual Intensive Update in Neurology 0915-162016

32

R Posterior to Lateral Canal conversion - geotropic

Sixth Annual Intensive Update in Neurology 0915-162016

33

BPPV Recurrence

bull Recurrence is common (15yr)

bull Otoconial adherence or mineralization demineralization

abnormalities may contribute to recurrence

bull Home canalith repositioning is effective (Radke 2004)

Sixth Annual Intensive Update in Neurology 0915-162016

34

Question 1

bull The most likely semicircular canal to be affected in

BPPV is

ndash 1) superior

ndash 2) lateral

ndash 3) posterior

ndash 4) combined

Sixth Annual Intensive Update in Neurology 0915-162016

35

Question 1

bull The most likely semicircular canal to be affected in

BPPV is

ndash 1) superior

ndash 2) lateral

ndash 3) posterior

ndash 4) combined

Answer 3 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

36

Acute Vestibular Syndrome

bull Rapid unilateral injury to either peripheral or central

vestibular structures produces prolonged vertigo

(days to weeks)

bull Severe vertigo nausea and vomiting spontaneous

nystagmus and postural instability

Sixth Annual Intensive Update in Neurology 0915-162016

37

Acute Vestibular Syndrome

bull 25 of patients with risk factors who present with isolated severe vertigo nystagmus and postural instability in the ER have an acute infarction of the inferior cerebellum (AICA PICA) Central imaging is suggested (Baloh 1998 NEJM)

ndash HTN diabetes smoking age gt65 Afib valvular heart disease occlusive vascular disease

Sixth Annual Intensive Update in Neurology 0915-162016

38

HINTS test

bull Head Impulse

bull Nystagmus

bull Test of Skew

ndash More sensitive than MRI in the diagnosis of acute stroke in

patients with acute vestibular syndrome with at least one risk

factor (Kattah J et al Stroke 2009)

Sixth Annual Intensive Update in Neurology 0915-162016

39

Head Impulse Test

bull No special equipment needed

bull Examiner stands in front of seated patient and

randomly moves head left and right Patient is asked to

focus on examinerrsquos nose

bull Rapid low amplitude thrust from lateral to straight

ahead causes a compensatory saccade when

performed towards the weak side

bull This finding is a permanent feature of unilateral

vestibular loss

Sixth Annual Intensive Update in Neurology 0915-162016

40

Head Impulse Test

Sixth Annual Intensive Update in Neurology 0915-162016

41

Head CT ndash Academy of Emergency Medicine 2013

bull The clinical value of head CT in isolated

dizzinessvertigo without any associated neurological

symptoms is very low

bull Less than 1 of head CTs ordered for dizziness and

vertigo have significant abnormalities and those

patients had severe headache and neurological deficits

in addition to dizziness

bull Forgoing unnecessary emergency head CTs could

save 360 million dollars annually

Sixth Annual Intensive Update in Neurology 0915-162016

42

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Sixth Annual Intensive Update in Neurology 0915-162016

43

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Answer 2 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

44

Acute Vestibular Syndrome

bull Usually peripheral and can be associated with

hearing loss (labyrinthitis)

bull Timely diagnosis improves recovery (ASAP

prednisone 1mgkgday for ten days and taper 10

mgday ndash Strupp M 2004 NEJM)

bull Avoid vestibular suppressants after 3 days and begin

vestibular rehabilitation to hasten compensation

Sixth Annual Intensive Update in Neurology 0915-162016

45

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

46

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Answer 5 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

47

Menierersquos syndrome

bull Fluctuating low frequency hearing loss

bull Tinnitus andor aural fullness

bull Vertigo lasting hours

Sixth Annual Intensive Update in Neurology 0915-162016

48

Normal

Sixth Annual Intensive Update in Neurology 0915-162016

49

Hydrops

Sixth Annual Intensive Update in Neurology 0915-162016

50

Menierersquos syndrome

ndash Diagnosis- Exclusion (RO acoustic)

ndash 23 of Menierersquos patients will improve spontaneously

ndash Treatment-1500 mgday low sodium triamterene375-

hydrochlorothiazide 25 vestibular suppressants (lorazepam

1 mg tablet sublingual Q 8 prn attacks) off label use

Sixth Annual Intensive Update in Neurology 0915-162016

51

Menierersquos syndrome ndash intratympanic steroids

ndash A newer treatment option for those failing medical management

ndash 90 response rate (Boleus-Aguirre MS Otology Neurotology

2008)

ndash Outcomes data confirm excellent clinical response in 3941

Menierersquos patients treated with intratympanic steroids in 2008

Sixth Annual Intensive Update in Neurology 0915-162016

52

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

53

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Answer 5 See references at end

Sixth Annual Intensive Update in Neurology 0915-162016

54

Superior Semicircular Canal Dehiscence (SSCD)

bull Sound andor pressure induced oscillopsia

bull CT reformatted in the plane of the superior canals

shows dehiscence of overlying bone

bull Low frequency ldquoconductive hyperacusisrdquo with elevated

bone thresholds normal reflexes and a conductive loss

Sixth Annual Intensive Update in Neurology 0915-162016

55

SSCD

bull Positive middle ear pressure or loud sound stimulates ampullofugal endolymph flow -canal activation

bull Eye movements are tonic upwards with ipsilateral intorsion

Sixth Annual Intensive Update in Neurology 0915-162016

56

SSCD

bull Valsalva against a closed glottis or jugular compression causes increased intracranial pressure and ampullopetal endolymph flow -canal inhibition

bull Eye movements are tonic downwards with ipsilateral extorsion

Sixth Annual Intensive Update in Neurology 0915-162016

57

Reconstructed left superior semicircular canal

Sixth Annual Intensive Update in Neurology 0915-162016

58

Sixth Annual Intensive Update in Neurology 0915-162016

59

SCHEMATIC DRAWING OF AN OTOLITHIC MACULA

Sixth Annual Intensive Update in Neurology 0915-162016

60

MACULAE OF THE UTRICLESACCULE

Sixth Annual Intensive Update in Neurology 0915-162016

61

HAIR CELLS

Sixth Annual Intensive Update in Neurology 0915-162016

62

SCANNING ELECTRON MICROGRAPH OF OTOCONIA

Sixth Annual Intensive Update in Neurology 0915-162016

63

Ocular VEMP

bull Response to loud clicks (80-110 dB) or forehead tap (Halmagyi and Curthoys 2003)

bull Contralateral oculomotor nucleus (CN III)

bull Inferior oblique muscle contraction (8 msec) detected by 5sec event triggered averaging

bull Noninverting electrode inferior to eye

bull Inverting below non-inverting electrode

bull Ground to forehead

bull Normal subjects have very low response

Sixth Annual Intensive Update in Neurology 0915-162016

64

Clinical applications

bull The o-VEMP is a sensitive test of otolithutricular

function

bull Complements vestibular test procedures that assess

semicircular canals

bull Abnormally robust responses are associated with third

window abnormalities such as semicircular canal

dehiscence

bull Serves as an excellent screening test for semicircular

canal dehiscence

Sixth Annual Intensive Update in Neurology 0915-162016

65

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Sixth Annual Intensive Update in Neurology 0915-162016

66

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Answer 1 References at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

67

Enlarged vestibular aqueduct

bull Axial temporal bone CT showing right temporal bone with enlarged vestibular aqueduct (arrow)

bull Vestibular symptoms accompany progressive sensorineural hearing loss in 4-50 of patients in selected series

Sixth Annual Intensive Update in Neurology 0915-162016

68

Migraine

bull Family or personal history of migraine

bull 25 of migraine patients experience spontaneous vertigo (Baloh 1997)

bull Neuhauser criteria(2001) have been used to construct structured diagnostic interviews (Furman 2003)

bull Not always associated with headache

bull Motion sensitivity

bull Medication responsive

Sixth Annual Intensive Update in Neurology 0915-162016

69

ICHD-III beta Criteria for Vestibular Migraine

bull A At least five attacks fulfilling criteria C and D

bull B A current or past history of 11 migraine without aura or 12 migraine with aura

bull C Vestibular symptoms of moderate or severe intensity lasting between 5 minutes and 72 hours

bull D At least 50 associated with one of the following migrainous features

ndash 1 Headaches

ndash 2 Photophobia and phonophobia

ndash 3 Visual Aura

bull E Not better accounted for by another vestibular disorder

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 7: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

7

Neuro-otology Physical Exam

bull Otologic ndash check hearing and rule out active infection or

cholesteatoma

bull Oculomotor- saccade pursuit in vertical and horizontal

planes

bull Nystagmus ndash spontaneous gaze evoked and

positionalpositioning testing (best observed using

Frenzel lenses)

bull Special testing ndash head thrust head shake

Sixth Annual Intensive Update in Neurology 0915-162016

8

Peripheral Nystagmus

bull Jerk nystagmus (slow

and fast phase)

bull Direction fixed

bull Generally beats away

from affected ear

bull Worse in the

direction of gaze that

is towards the fast

phase

Sixth Annual Intensive Update in Neurology 0915-162016

9

Benign Paroxysmal Positional Vertigo (BPPV)

bull Vertigo of sudden onset and brief duration provoked by changes in head positionndash Lying down

ndash Rolling over in bed

ndash Bending over

ndash Looking up

ndash Washing hair in shower

ndash Dentist or beauty parlor

Sixth Annual Intensive Update in Neurology 0915-162016

10

Right Posterior BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

11

IncidencePrevalence of BPPV

bull Most common referred diagnosis in tertiary centers

bull 9 of randomly selected community dwelling elderly

(Oghalai JS et al 2000)

bull Incidence increases 38 with each decade of life

(Froehling 1991)

Sixth Annual Intensive Update in Neurology 0915-162016

12

Benign Positional Vertigo (BPPV)

bull Diagnosed with lateral supine head turns and Dix-

Hallpike positioning

ndash Latency

ndash Duration

ndash Fatigue

ndash Habituation

Sixth Annual Intensive Update in Neurology 0915-162016

13

DHT - Sitting

Sixth Annual Intensive Update in Neurology 0915-162016

14

DHT - HHR Orientation

Sixth Annual Intensive Update in Neurology 0915-162016

15

Dix-Hallpike to the Right

Sixth Annual Intensive Update in Neurology 0915-162016

16

Right posterior BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

17

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

18

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

19

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

20

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

21

Canalith Repositioning

bull R posterior

BPPV

CPT 95992

Sixth Annual Intensive Update in Neurology 0915-162016

22

Posterior semicircular canalith repositioning

Sixth Annual Intensive Update in Neurology 0915-162016

23

Supine Positional Tests

Sixth Annual Intensive Update in Neurology 0915-162016

24

Lateral SCC-BPPV

bull Short latency horizontal nystagmus provoked by supine bilateral head turns with prolonged duration and poor fatigability

bull Uncommon (2-15 of total BPPV)

bull Two formsndash Geotropic ndash beating towards undermost ear

ndash Apogeotropic ndash beating away from undermost ear

Sixth Annual Intensive Update in Neurology 0915-162016

25

Geotropic Lateral Canal BPPV

bull Patient is positioned

first to the right lateral

position ndash nystagmus

beats right

bull Patient is then

positioned to the left

lateral position and

nystagmus reverses

and beats left

Sixth Annual Intensive Update in Neurology 0915-162016

26

Left Geotropic Lateral Semicircular Canal BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

27

Repositioning Maneuvers for Geotropic Lateral Semicircular Canal (LSC) BPPV

bull Roll maneuver (Lempert Baloh)

ndash Patient rolls in 90 degree increments towards the good side

completely rolling over R LSC-BPPV repositioning shown

Sixth Annual Intensive Update in Neurology 0915-162016

28

Repositioning Maneuvers for Geotropic LSC BPPV

bull Gufoni maneuver

ndash Patient lies quickly onto good side and turns face-down to

floor for two minutes

Sixth Annual Intensive Update in Neurology 0915-162016

29

Left Apogeotropic LSC BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

30

Nystagmus observed During Repositioning

bull Nystagmus should remain in the same torsional

direction as seen on DHT throughout the treatment of

posterior BPPV

bull Reversal of nystagmus direction suggests the particle

has fallen back into the canal and predicts failure

bull In Lateral BPPV nystagmus should beat towards the

good ear

Sixth Annual Intensive Update in Neurology 0915-162016

31

Posterior to Lateral canal conversion

Sixth Annual Intensive Update in Neurology 0915-162016

32

R Posterior to Lateral Canal conversion - geotropic

Sixth Annual Intensive Update in Neurology 0915-162016

33

BPPV Recurrence

bull Recurrence is common (15yr)

bull Otoconial adherence or mineralization demineralization

abnormalities may contribute to recurrence

bull Home canalith repositioning is effective (Radke 2004)

Sixth Annual Intensive Update in Neurology 0915-162016

34

Question 1

bull The most likely semicircular canal to be affected in

BPPV is

ndash 1) superior

ndash 2) lateral

ndash 3) posterior

ndash 4) combined

Sixth Annual Intensive Update in Neurology 0915-162016

35

Question 1

bull The most likely semicircular canal to be affected in

BPPV is

ndash 1) superior

ndash 2) lateral

ndash 3) posterior

ndash 4) combined

Answer 3 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

36

Acute Vestibular Syndrome

bull Rapid unilateral injury to either peripheral or central

vestibular structures produces prolonged vertigo

(days to weeks)

bull Severe vertigo nausea and vomiting spontaneous

nystagmus and postural instability

Sixth Annual Intensive Update in Neurology 0915-162016

37

Acute Vestibular Syndrome

bull 25 of patients with risk factors who present with isolated severe vertigo nystagmus and postural instability in the ER have an acute infarction of the inferior cerebellum (AICA PICA) Central imaging is suggested (Baloh 1998 NEJM)

ndash HTN diabetes smoking age gt65 Afib valvular heart disease occlusive vascular disease

Sixth Annual Intensive Update in Neurology 0915-162016

38

HINTS test

bull Head Impulse

bull Nystagmus

bull Test of Skew

ndash More sensitive than MRI in the diagnosis of acute stroke in

patients with acute vestibular syndrome with at least one risk

factor (Kattah J et al Stroke 2009)

Sixth Annual Intensive Update in Neurology 0915-162016

39

Head Impulse Test

bull No special equipment needed

bull Examiner stands in front of seated patient and

randomly moves head left and right Patient is asked to

focus on examinerrsquos nose

bull Rapid low amplitude thrust from lateral to straight

ahead causes a compensatory saccade when

performed towards the weak side

bull This finding is a permanent feature of unilateral

vestibular loss

Sixth Annual Intensive Update in Neurology 0915-162016

40

Head Impulse Test

Sixth Annual Intensive Update in Neurology 0915-162016

41

Head CT ndash Academy of Emergency Medicine 2013

bull The clinical value of head CT in isolated

dizzinessvertigo without any associated neurological

symptoms is very low

bull Less than 1 of head CTs ordered for dizziness and

vertigo have significant abnormalities and those

patients had severe headache and neurological deficits

in addition to dizziness

bull Forgoing unnecessary emergency head CTs could

save 360 million dollars annually

Sixth Annual Intensive Update in Neurology 0915-162016

42

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Sixth Annual Intensive Update in Neurology 0915-162016

43

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Answer 2 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

44

Acute Vestibular Syndrome

bull Usually peripheral and can be associated with

hearing loss (labyrinthitis)

bull Timely diagnosis improves recovery (ASAP

prednisone 1mgkgday for ten days and taper 10

mgday ndash Strupp M 2004 NEJM)

bull Avoid vestibular suppressants after 3 days and begin

vestibular rehabilitation to hasten compensation

Sixth Annual Intensive Update in Neurology 0915-162016

45

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

46

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Answer 5 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

47

Menierersquos syndrome

bull Fluctuating low frequency hearing loss

bull Tinnitus andor aural fullness

bull Vertigo lasting hours

Sixth Annual Intensive Update in Neurology 0915-162016

48

Normal

Sixth Annual Intensive Update in Neurology 0915-162016

49

Hydrops

Sixth Annual Intensive Update in Neurology 0915-162016

50

Menierersquos syndrome

ndash Diagnosis- Exclusion (RO acoustic)

ndash 23 of Menierersquos patients will improve spontaneously

ndash Treatment-1500 mgday low sodium triamterene375-

hydrochlorothiazide 25 vestibular suppressants (lorazepam

1 mg tablet sublingual Q 8 prn attacks) off label use

Sixth Annual Intensive Update in Neurology 0915-162016

51

Menierersquos syndrome ndash intratympanic steroids

ndash A newer treatment option for those failing medical management

ndash 90 response rate (Boleus-Aguirre MS Otology Neurotology

2008)

ndash Outcomes data confirm excellent clinical response in 3941

Menierersquos patients treated with intratympanic steroids in 2008

Sixth Annual Intensive Update in Neurology 0915-162016

52

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

53

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Answer 5 See references at end

Sixth Annual Intensive Update in Neurology 0915-162016

54

Superior Semicircular Canal Dehiscence (SSCD)

bull Sound andor pressure induced oscillopsia

bull CT reformatted in the plane of the superior canals

shows dehiscence of overlying bone

bull Low frequency ldquoconductive hyperacusisrdquo with elevated

bone thresholds normal reflexes and a conductive loss

Sixth Annual Intensive Update in Neurology 0915-162016

55

SSCD

bull Positive middle ear pressure or loud sound stimulates ampullofugal endolymph flow -canal activation

bull Eye movements are tonic upwards with ipsilateral intorsion

Sixth Annual Intensive Update in Neurology 0915-162016

56

SSCD

bull Valsalva against a closed glottis or jugular compression causes increased intracranial pressure and ampullopetal endolymph flow -canal inhibition

bull Eye movements are tonic downwards with ipsilateral extorsion

Sixth Annual Intensive Update in Neurology 0915-162016

57

Reconstructed left superior semicircular canal

Sixth Annual Intensive Update in Neurology 0915-162016

58

Sixth Annual Intensive Update in Neurology 0915-162016

59

SCHEMATIC DRAWING OF AN OTOLITHIC MACULA

Sixth Annual Intensive Update in Neurology 0915-162016

60

MACULAE OF THE UTRICLESACCULE

Sixth Annual Intensive Update in Neurology 0915-162016

61

HAIR CELLS

Sixth Annual Intensive Update in Neurology 0915-162016

62

SCANNING ELECTRON MICROGRAPH OF OTOCONIA

Sixth Annual Intensive Update in Neurology 0915-162016

63

Ocular VEMP

bull Response to loud clicks (80-110 dB) or forehead tap (Halmagyi and Curthoys 2003)

bull Contralateral oculomotor nucleus (CN III)

bull Inferior oblique muscle contraction (8 msec) detected by 5sec event triggered averaging

bull Noninverting electrode inferior to eye

bull Inverting below non-inverting electrode

bull Ground to forehead

bull Normal subjects have very low response

Sixth Annual Intensive Update in Neurology 0915-162016

64

Clinical applications

bull The o-VEMP is a sensitive test of otolithutricular

function

bull Complements vestibular test procedures that assess

semicircular canals

bull Abnormally robust responses are associated with third

window abnormalities such as semicircular canal

dehiscence

bull Serves as an excellent screening test for semicircular

canal dehiscence

Sixth Annual Intensive Update in Neurology 0915-162016

65

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Sixth Annual Intensive Update in Neurology 0915-162016

66

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Answer 1 References at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

67

Enlarged vestibular aqueduct

bull Axial temporal bone CT showing right temporal bone with enlarged vestibular aqueduct (arrow)

bull Vestibular symptoms accompany progressive sensorineural hearing loss in 4-50 of patients in selected series

Sixth Annual Intensive Update in Neurology 0915-162016

68

Migraine

bull Family or personal history of migraine

bull 25 of migraine patients experience spontaneous vertigo (Baloh 1997)

bull Neuhauser criteria(2001) have been used to construct structured diagnostic interviews (Furman 2003)

bull Not always associated with headache

bull Motion sensitivity

bull Medication responsive

Sixth Annual Intensive Update in Neurology 0915-162016

69

ICHD-III beta Criteria for Vestibular Migraine

bull A At least five attacks fulfilling criteria C and D

bull B A current or past history of 11 migraine without aura or 12 migraine with aura

bull C Vestibular symptoms of moderate or severe intensity lasting between 5 minutes and 72 hours

bull D At least 50 associated with one of the following migrainous features

ndash 1 Headaches

ndash 2 Photophobia and phonophobia

ndash 3 Visual Aura

bull E Not better accounted for by another vestibular disorder

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 8: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

8

Peripheral Nystagmus

bull Jerk nystagmus (slow

and fast phase)

bull Direction fixed

bull Generally beats away

from affected ear

bull Worse in the

direction of gaze that

is towards the fast

phase

Sixth Annual Intensive Update in Neurology 0915-162016

9

Benign Paroxysmal Positional Vertigo (BPPV)

bull Vertigo of sudden onset and brief duration provoked by changes in head positionndash Lying down

ndash Rolling over in bed

ndash Bending over

ndash Looking up

ndash Washing hair in shower

ndash Dentist or beauty parlor

Sixth Annual Intensive Update in Neurology 0915-162016

10

Right Posterior BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

11

IncidencePrevalence of BPPV

bull Most common referred diagnosis in tertiary centers

bull 9 of randomly selected community dwelling elderly

(Oghalai JS et al 2000)

bull Incidence increases 38 with each decade of life

(Froehling 1991)

Sixth Annual Intensive Update in Neurology 0915-162016

12

Benign Positional Vertigo (BPPV)

bull Diagnosed with lateral supine head turns and Dix-

Hallpike positioning

ndash Latency

ndash Duration

ndash Fatigue

ndash Habituation

Sixth Annual Intensive Update in Neurology 0915-162016

13

DHT - Sitting

Sixth Annual Intensive Update in Neurology 0915-162016

14

DHT - HHR Orientation

Sixth Annual Intensive Update in Neurology 0915-162016

15

Dix-Hallpike to the Right

Sixth Annual Intensive Update in Neurology 0915-162016

16

Right posterior BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

17

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

18

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

19

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

20

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

21

Canalith Repositioning

bull R posterior

BPPV

CPT 95992

Sixth Annual Intensive Update in Neurology 0915-162016

22

Posterior semicircular canalith repositioning

Sixth Annual Intensive Update in Neurology 0915-162016

23

Supine Positional Tests

Sixth Annual Intensive Update in Neurology 0915-162016

24

Lateral SCC-BPPV

bull Short latency horizontal nystagmus provoked by supine bilateral head turns with prolonged duration and poor fatigability

bull Uncommon (2-15 of total BPPV)

bull Two formsndash Geotropic ndash beating towards undermost ear

ndash Apogeotropic ndash beating away from undermost ear

Sixth Annual Intensive Update in Neurology 0915-162016

25

Geotropic Lateral Canal BPPV

bull Patient is positioned

first to the right lateral

position ndash nystagmus

beats right

bull Patient is then

positioned to the left

lateral position and

nystagmus reverses

and beats left

Sixth Annual Intensive Update in Neurology 0915-162016

26

Left Geotropic Lateral Semicircular Canal BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

27

Repositioning Maneuvers for Geotropic Lateral Semicircular Canal (LSC) BPPV

bull Roll maneuver (Lempert Baloh)

ndash Patient rolls in 90 degree increments towards the good side

completely rolling over R LSC-BPPV repositioning shown

Sixth Annual Intensive Update in Neurology 0915-162016

28

Repositioning Maneuvers for Geotropic LSC BPPV

bull Gufoni maneuver

ndash Patient lies quickly onto good side and turns face-down to

floor for two minutes

Sixth Annual Intensive Update in Neurology 0915-162016

29

Left Apogeotropic LSC BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

30

Nystagmus observed During Repositioning

bull Nystagmus should remain in the same torsional

direction as seen on DHT throughout the treatment of

posterior BPPV

bull Reversal of nystagmus direction suggests the particle

has fallen back into the canal and predicts failure

bull In Lateral BPPV nystagmus should beat towards the

good ear

Sixth Annual Intensive Update in Neurology 0915-162016

31

Posterior to Lateral canal conversion

Sixth Annual Intensive Update in Neurology 0915-162016

32

R Posterior to Lateral Canal conversion - geotropic

Sixth Annual Intensive Update in Neurology 0915-162016

33

BPPV Recurrence

bull Recurrence is common (15yr)

bull Otoconial adherence or mineralization demineralization

abnormalities may contribute to recurrence

bull Home canalith repositioning is effective (Radke 2004)

Sixth Annual Intensive Update in Neurology 0915-162016

34

Question 1

bull The most likely semicircular canal to be affected in

BPPV is

ndash 1) superior

ndash 2) lateral

ndash 3) posterior

ndash 4) combined

Sixth Annual Intensive Update in Neurology 0915-162016

35

Question 1

bull The most likely semicircular canal to be affected in

BPPV is

ndash 1) superior

ndash 2) lateral

ndash 3) posterior

ndash 4) combined

Answer 3 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

36

Acute Vestibular Syndrome

bull Rapid unilateral injury to either peripheral or central

vestibular structures produces prolonged vertigo

(days to weeks)

bull Severe vertigo nausea and vomiting spontaneous

nystagmus and postural instability

Sixth Annual Intensive Update in Neurology 0915-162016

37

Acute Vestibular Syndrome

bull 25 of patients with risk factors who present with isolated severe vertigo nystagmus and postural instability in the ER have an acute infarction of the inferior cerebellum (AICA PICA) Central imaging is suggested (Baloh 1998 NEJM)

ndash HTN diabetes smoking age gt65 Afib valvular heart disease occlusive vascular disease

Sixth Annual Intensive Update in Neurology 0915-162016

38

HINTS test

bull Head Impulse

bull Nystagmus

bull Test of Skew

ndash More sensitive than MRI in the diagnosis of acute stroke in

patients with acute vestibular syndrome with at least one risk

factor (Kattah J et al Stroke 2009)

Sixth Annual Intensive Update in Neurology 0915-162016

39

Head Impulse Test

bull No special equipment needed

bull Examiner stands in front of seated patient and

randomly moves head left and right Patient is asked to

focus on examinerrsquos nose

bull Rapid low amplitude thrust from lateral to straight

ahead causes a compensatory saccade when

performed towards the weak side

bull This finding is a permanent feature of unilateral

vestibular loss

Sixth Annual Intensive Update in Neurology 0915-162016

40

Head Impulse Test

Sixth Annual Intensive Update in Neurology 0915-162016

41

Head CT ndash Academy of Emergency Medicine 2013

bull The clinical value of head CT in isolated

dizzinessvertigo without any associated neurological

symptoms is very low

bull Less than 1 of head CTs ordered for dizziness and

vertigo have significant abnormalities and those

patients had severe headache and neurological deficits

in addition to dizziness

bull Forgoing unnecessary emergency head CTs could

save 360 million dollars annually

Sixth Annual Intensive Update in Neurology 0915-162016

42

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Sixth Annual Intensive Update in Neurology 0915-162016

43

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Answer 2 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

44

Acute Vestibular Syndrome

bull Usually peripheral and can be associated with

hearing loss (labyrinthitis)

bull Timely diagnosis improves recovery (ASAP

prednisone 1mgkgday for ten days and taper 10

mgday ndash Strupp M 2004 NEJM)

bull Avoid vestibular suppressants after 3 days and begin

vestibular rehabilitation to hasten compensation

Sixth Annual Intensive Update in Neurology 0915-162016

45

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

46

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Answer 5 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

47

Menierersquos syndrome

bull Fluctuating low frequency hearing loss

bull Tinnitus andor aural fullness

bull Vertigo lasting hours

Sixth Annual Intensive Update in Neurology 0915-162016

48

Normal

Sixth Annual Intensive Update in Neurology 0915-162016

49

Hydrops

Sixth Annual Intensive Update in Neurology 0915-162016

50

Menierersquos syndrome

ndash Diagnosis- Exclusion (RO acoustic)

ndash 23 of Menierersquos patients will improve spontaneously

ndash Treatment-1500 mgday low sodium triamterene375-

hydrochlorothiazide 25 vestibular suppressants (lorazepam

1 mg tablet sublingual Q 8 prn attacks) off label use

Sixth Annual Intensive Update in Neurology 0915-162016

51

Menierersquos syndrome ndash intratympanic steroids

ndash A newer treatment option for those failing medical management

ndash 90 response rate (Boleus-Aguirre MS Otology Neurotology

2008)

ndash Outcomes data confirm excellent clinical response in 3941

Menierersquos patients treated with intratympanic steroids in 2008

Sixth Annual Intensive Update in Neurology 0915-162016

52

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

53

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Answer 5 See references at end

Sixth Annual Intensive Update in Neurology 0915-162016

54

Superior Semicircular Canal Dehiscence (SSCD)

bull Sound andor pressure induced oscillopsia

bull CT reformatted in the plane of the superior canals

shows dehiscence of overlying bone

bull Low frequency ldquoconductive hyperacusisrdquo with elevated

bone thresholds normal reflexes and a conductive loss

Sixth Annual Intensive Update in Neurology 0915-162016

55

SSCD

bull Positive middle ear pressure or loud sound stimulates ampullofugal endolymph flow -canal activation

bull Eye movements are tonic upwards with ipsilateral intorsion

Sixth Annual Intensive Update in Neurology 0915-162016

56

SSCD

bull Valsalva against a closed glottis or jugular compression causes increased intracranial pressure and ampullopetal endolymph flow -canal inhibition

bull Eye movements are tonic downwards with ipsilateral extorsion

Sixth Annual Intensive Update in Neurology 0915-162016

57

Reconstructed left superior semicircular canal

Sixth Annual Intensive Update in Neurology 0915-162016

58

Sixth Annual Intensive Update in Neurology 0915-162016

59

SCHEMATIC DRAWING OF AN OTOLITHIC MACULA

Sixth Annual Intensive Update in Neurology 0915-162016

60

MACULAE OF THE UTRICLESACCULE

Sixth Annual Intensive Update in Neurology 0915-162016

61

HAIR CELLS

Sixth Annual Intensive Update in Neurology 0915-162016

62

SCANNING ELECTRON MICROGRAPH OF OTOCONIA

Sixth Annual Intensive Update in Neurology 0915-162016

63

Ocular VEMP

bull Response to loud clicks (80-110 dB) or forehead tap (Halmagyi and Curthoys 2003)

bull Contralateral oculomotor nucleus (CN III)

bull Inferior oblique muscle contraction (8 msec) detected by 5sec event triggered averaging

bull Noninverting electrode inferior to eye

bull Inverting below non-inverting electrode

bull Ground to forehead

bull Normal subjects have very low response

Sixth Annual Intensive Update in Neurology 0915-162016

64

Clinical applications

bull The o-VEMP is a sensitive test of otolithutricular

function

bull Complements vestibular test procedures that assess

semicircular canals

bull Abnormally robust responses are associated with third

window abnormalities such as semicircular canal

dehiscence

bull Serves as an excellent screening test for semicircular

canal dehiscence

Sixth Annual Intensive Update in Neurology 0915-162016

65

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Sixth Annual Intensive Update in Neurology 0915-162016

66

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Answer 1 References at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

67

Enlarged vestibular aqueduct

bull Axial temporal bone CT showing right temporal bone with enlarged vestibular aqueduct (arrow)

bull Vestibular symptoms accompany progressive sensorineural hearing loss in 4-50 of patients in selected series

Sixth Annual Intensive Update in Neurology 0915-162016

68

Migraine

bull Family or personal history of migraine

bull 25 of migraine patients experience spontaneous vertigo (Baloh 1997)

bull Neuhauser criteria(2001) have been used to construct structured diagnostic interviews (Furman 2003)

bull Not always associated with headache

bull Motion sensitivity

bull Medication responsive

Sixth Annual Intensive Update in Neurology 0915-162016

69

ICHD-III beta Criteria for Vestibular Migraine

bull A At least five attacks fulfilling criteria C and D

bull B A current or past history of 11 migraine without aura or 12 migraine with aura

bull C Vestibular symptoms of moderate or severe intensity lasting between 5 minutes and 72 hours

bull D At least 50 associated with one of the following migrainous features

ndash 1 Headaches

ndash 2 Photophobia and phonophobia

ndash 3 Visual Aura

bull E Not better accounted for by another vestibular disorder

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 9: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

9

Benign Paroxysmal Positional Vertigo (BPPV)

bull Vertigo of sudden onset and brief duration provoked by changes in head positionndash Lying down

ndash Rolling over in bed

ndash Bending over

ndash Looking up

ndash Washing hair in shower

ndash Dentist or beauty parlor

Sixth Annual Intensive Update in Neurology 0915-162016

10

Right Posterior BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

11

IncidencePrevalence of BPPV

bull Most common referred diagnosis in tertiary centers

bull 9 of randomly selected community dwelling elderly

(Oghalai JS et al 2000)

bull Incidence increases 38 with each decade of life

(Froehling 1991)

Sixth Annual Intensive Update in Neurology 0915-162016

12

Benign Positional Vertigo (BPPV)

bull Diagnosed with lateral supine head turns and Dix-

Hallpike positioning

ndash Latency

ndash Duration

ndash Fatigue

ndash Habituation

Sixth Annual Intensive Update in Neurology 0915-162016

13

DHT - Sitting

Sixth Annual Intensive Update in Neurology 0915-162016

14

DHT - HHR Orientation

Sixth Annual Intensive Update in Neurology 0915-162016

15

Dix-Hallpike to the Right

Sixth Annual Intensive Update in Neurology 0915-162016

16

Right posterior BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

17

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

18

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

19

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

20

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

21

Canalith Repositioning

bull R posterior

BPPV

CPT 95992

Sixth Annual Intensive Update in Neurology 0915-162016

22

Posterior semicircular canalith repositioning

Sixth Annual Intensive Update in Neurology 0915-162016

23

Supine Positional Tests

Sixth Annual Intensive Update in Neurology 0915-162016

24

Lateral SCC-BPPV

bull Short latency horizontal nystagmus provoked by supine bilateral head turns with prolonged duration and poor fatigability

bull Uncommon (2-15 of total BPPV)

bull Two formsndash Geotropic ndash beating towards undermost ear

ndash Apogeotropic ndash beating away from undermost ear

Sixth Annual Intensive Update in Neurology 0915-162016

25

Geotropic Lateral Canal BPPV

bull Patient is positioned

first to the right lateral

position ndash nystagmus

beats right

bull Patient is then

positioned to the left

lateral position and

nystagmus reverses

and beats left

Sixth Annual Intensive Update in Neurology 0915-162016

26

Left Geotropic Lateral Semicircular Canal BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

27

Repositioning Maneuvers for Geotropic Lateral Semicircular Canal (LSC) BPPV

bull Roll maneuver (Lempert Baloh)

ndash Patient rolls in 90 degree increments towards the good side

completely rolling over R LSC-BPPV repositioning shown

Sixth Annual Intensive Update in Neurology 0915-162016

28

Repositioning Maneuvers for Geotropic LSC BPPV

bull Gufoni maneuver

ndash Patient lies quickly onto good side and turns face-down to

floor for two minutes

Sixth Annual Intensive Update in Neurology 0915-162016

29

Left Apogeotropic LSC BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

30

Nystagmus observed During Repositioning

bull Nystagmus should remain in the same torsional

direction as seen on DHT throughout the treatment of

posterior BPPV

bull Reversal of nystagmus direction suggests the particle

has fallen back into the canal and predicts failure

bull In Lateral BPPV nystagmus should beat towards the

good ear

Sixth Annual Intensive Update in Neurology 0915-162016

31

Posterior to Lateral canal conversion

Sixth Annual Intensive Update in Neurology 0915-162016

32

R Posterior to Lateral Canal conversion - geotropic

Sixth Annual Intensive Update in Neurology 0915-162016

33

BPPV Recurrence

bull Recurrence is common (15yr)

bull Otoconial adherence or mineralization demineralization

abnormalities may contribute to recurrence

bull Home canalith repositioning is effective (Radke 2004)

Sixth Annual Intensive Update in Neurology 0915-162016

34

Question 1

bull The most likely semicircular canal to be affected in

BPPV is

ndash 1) superior

ndash 2) lateral

ndash 3) posterior

ndash 4) combined

Sixth Annual Intensive Update in Neurology 0915-162016

35

Question 1

bull The most likely semicircular canal to be affected in

BPPV is

ndash 1) superior

ndash 2) lateral

ndash 3) posterior

ndash 4) combined

Answer 3 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

36

Acute Vestibular Syndrome

bull Rapid unilateral injury to either peripheral or central

vestibular structures produces prolonged vertigo

(days to weeks)

bull Severe vertigo nausea and vomiting spontaneous

nystagmus and postural instability

Sixth Annual Intensive Update in Neurology 0915-162016

37

Acute Vestibular Syndrome

bull 25 of patients with risk factors who present with isolated severe vertigo nystagmus and postural instability in the ER have an acute infarction of the inferior cerebellum (AICA PICA) Central imaging is suggested (Baloh 1998 NEJM)

ndash HTN diabetes smoking age gt65 Afib valvular heart disease occlusive vascular disease

Sixth Annual Intensive Update in Neurology 0915-162016

38

HINTS test

bull Head Impulse

bull Nystagmus

bull Test of Skew

ndash More sensitive than MRI in the diagnosis of acute stroke in

patients with acute vestibular syndrome with at least one risk

factor (Kattah J et al Stroke 2009)

Sixth Annual Intensive Update in Neurology 0915-162016

39

Head Impulse Test

bull No special equipment needed

bull Examiner stands in front of seated patient and

randomly moves head left and right Patient is asked to

focus on examinerrsquos nose

bull Rapid low amplitude thrust from lateral to straight

ahead causes a compensatory saccade when

performed towards the weak side

bull This finding is a permanent feature of unilateral

vestibular loss

Sixth Annual Intensive Update in Neurology 0915-162016

40

Head Impulse Test

Sixth Annual Intensive Update in Neurology 0915-162016

41

Head CT ndash Academy of Emergency Medicine 2013

bull The clinical value of head CT in isolated

dizzinessvertigo without any associated neurological

symptoms is very low

bull Less than 1 of head CTs ordered for dizziness and

vertigo have significant abnormalities and those

patients had severe headache and neurological deficits

in addition to dizziness

bull Forgoing unnecessary emergency head CTs could

save 360 million dollars annually

Sixth Annual Intensive Update in Neurology 0915-162016

42

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Sixth Annual Intensive Update in Neurology 0915-162016

43

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Answer 2 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

44

Acute Vestibular Syndrome

bull Usually peripheral and can be associated with

hearing loss (labyrinthitis)

bull Timely diagnosis improves recovery (ASAP

prednisone 1mgkgday for ten days and taper 10

mgday ndash Strupp M 2004 NEJM)

bull Avoid vestibular suppressants after 3 days and begin

vestibular rehabilitation to hasten compensation

Sixth Annual Intensive Update in Neurology 0915-162016

45

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

46

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Answer 5 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

47

Menierersquos syndrome

bull Fluctuating low frequency hearing loss

bull Tinnitus andor aural fullness

bull Vertigo lasting hours

Sixth Annual Intensive Update in Neurology 0915-162016

48

Normal

Sixth Annual Intensive Update in Neurology 0915-162016

49

Hydrops

Sixth Annual Intensive Update in Neurology 0915-162016

50

Menierersquos syndrome

ndash Diagnosis- Exclusion (RO acoustic)

ndash 23 of Menierersquos patients will improve spontaneously

ndash Treatment-1500 mgday low sodium triamterene375-

hydrochlorothiazide 25 vestibular suppressants (lorazepam

1 mg tablet sublingual Q 8 prn attacks) off label use

Sixth Annual Intensive Update in Neurology 0915-162016

51

Menierersquos syndrome ndash intratympanic steroids

ndash A newer treatment option for those failing medical management

ndash 90 response rate (Boleus-Aguirre MS Otology Neurotology

2008)

ndash Outcomes data confirm excellent clinical response in 3941

Menierersquos patients treated with intratympanic steroids in 2008

Sixth Annual Intensive Update in Neurology 0915-162016

52

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

53

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Answer 5 See references at end

Sixth Annual Intensive Update in Neurology 0915-162016

54

Superior Semicircular Canal Dehiscence (SSCD)

bull Sound andor pressure induced oscillopsia

bull CT reformatted in the plane of the superior canals

shows dehiscence of overlying bone

bull Low frequency ldquoconductive hyperacusisrdquo with elevated

bone thresholds normal reflexes and a conductive loss

Sixth Annual Intensive Update in Neurology 0915-162016

55

SSCD

bull Positive middle ear pressure or loud sound stimulates ampullofugal endolymph flow -canal activation

bull Eye movements are tonic upwards with ipsilateral intorsion

Sixth Annual Intensive Update in Neurology 0915-162016

56

SSCD

bull Valsalva against a closed glottis or jugular compression causes increased intracranial pressure and ampullopetal endolymph flow -canal inhibition

bull Eye movements are tonic downwards with ipsilateral extorsion

Sixth Annual Intensive Update in Neurology 0915-162016

57

Reconstructed left superior semicircular canal

Sixth Annual Intensive Update in Neurology 0915-162016

58

Sixth Annual Intensive Update in Neurology 0915-162016

59

SCHEMATIC DRAWING OF AN OTOLITHIC MACULA

Sixth Annual Intensive Update in Neurology 0915-162016

60

MACULAE OF THE UTRICLESACCULE

Sixth Annual Intensive Update in Neurology 0915-162016

61

HAIR CELLS

Sixth Annual Intensive Update in Neurology 0915-162016

62

SCANNING ELECTRON MICROGRAPH OF OTOCONIA

Sixth Annual Intensive Update in Neurology 0915-162016

63

Ocular VEMP

bull Response to loud clicks (80-110 dB) or forehead tap (Halmagyi and Curthoys 2003)

bull Contralateral oculomotor nucleus (CN III)

bull Inferior oblique muscle contraction (8 msec) detected by 5sec event triggered averaging

bull Noninverting electrode inferior to eye

bull Inverting below non-inverting electrode

bull Ground to forehead

bull Normal subjects have very low response

Sixth Annual Intensive Update in Neurology 0915-162016

64

Clinical applications

bull The o-VEMP is a sensitive test of otolithutricular

function

bull Complements vestibular test procedures that assess

semicircular canals

bull Abnormally robust responses are associated with third

window abnormalities such as semicircular canal

dehiscence

bull Serves as an excellent screening test for semicircular

canal dehiscence

Sixth Annual Intensive Update in Neurology 0915-162016

65

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Sixth Annual Intensive Update in Neurology 0915-162016

66

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Answer 1 References at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

67

Enlarged vestibular aqueduct

bull Axial temporal bone CT showing right temporal bone with enlarged vestibular aqueduct (arrow)

bull Vestibular symptoms accompany progressive sensorineural hearing loss in 4-50 of patients in selected series

Sixth Annual Intensive Update in Neurology 0915-162016

68

Migraine

bull Family or personal history of migraine

bull 25 of migraine patients experience spontaneous vertigo (Baloh 1997)

bull Neuhauser criteria(2001) have been used to construct structured diagnostic interviews (Furman 2003)

bull Not always associated with headache

bull Motion sensitivity

bull Medication responsive

Sixth Annual Intensive Update in Neurology 0915-162016

69

ICHD-III beta Criteria for Vestibular Migraine

bull A At least five attacks fulfilling criteria C and D

bull B A current or past history of 11 migraine without aura or 12 migraine with aura

bull C Vestibular symptoms of moderate or severe intensity lasting between 5 minutes and 72 hours

bull D At least 50 associated with one of the following migrainous features

ndash 1 Headaches

ndash 2 Photophobia and phonophobia

ndash 3 Visual Aura

bull E Not better accounted for by another vestibular disorder

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 10: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

10

Right Posterior BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

11

IncidencePrevalence of BPPV

bull Most common referred diagnosis in tertiary centers

bull 9 of randomly selected community dwelling elderly

(Oghalai JS et al 2000)

bull Incidence increases 38 with each decade of life

(Froehling 1991)

Sixth Annual Intensive Update in Neurology 0915-162016

12

Benign Positional Vertigo (BPPV)

bull Diagnosed with lateral supine head turns and Dix-

Hallpike positioning

ndash Latency

ndash Duration

ndash Fatigue

ndash Habituation

Sixth Annual Intensive Update in Neurology 0915-162016

13

DHT - Sitting

Sixth Annual Intensive Update in Neurology 0915-162016

14

DHT - HHR Orientation

Sixth Annual Intensive Update in Neurology 0915-162016

15

Dix-Hallpike to the Right

Sixth Annual Intensive Update in Neurology 0915-162016

16

Right posterior BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

17

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

18

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

19

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

20

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

21

Canalith Repositioning

bull R posterior

BPPV

CPT 95992

Sixth Annual Intensive Update in Neurology 0915-162016

22

Posterior semicircular canalith repositioning

Sixth Annual Intensive Update in Neurology 0915-162016

23

Supine Positional Tests

Sixth Annual Intensive Update in Neurology 0915-162016

24

Lateral SCC-BPPV

bull Short latency horizontal nystagmus provoked by supine bilateral head turns with prolonged duration and poor fatigability

bull Uncommon (2-15 of total BPPV)

bull Two formsndash Geotropic ndash beating towards undermost ear

ndash Apogeotropic ndash beating away from undermost ear

Sixth Annual Intensive Update in Neurology 0915-162016

25

Geotropic Lateral Canal BPPV

bull Patient is positioned

first to the right lateral

position ndash nystagmus

beats right

bull Patient is then

positioned to the left

lateral position and

nystagmus reverses

and beats left

Sixth Annual Intensive Update in Neurology 0915-162016

26

Left Geotropic Lateral Semicircular Canal BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

27

Repositioning Maneuvers for Geotropic Lateral Semicircular Canal (LSC) BPPV

bull Roll maneuver (Lempert Baloh)

ndash Patient rolls in 90 degree increments towards the good side

completely rolling over R LSC-BPPV repositioning shown

Sixth Annual Intensive Update in Neurology 0915-162016

28

Repositioning Maneuvers for Geotropic LSC BPPV

bull Gufoni maneuver

ndash Patient lies quickly onto good side and turns face-down to

floor for two minutes

Sixth Annual Intensive Update in Neurology 0915-162016

29

Left Apogeotropic LSC BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

30

Nystagmus observed During Repositioning

bull Nystagmus should remain in the same torsional

direction as seen on DHT throughout the treatment of

posterior BPPV

bull Reversal of nystagmus direction suggests the particle

has fallen back into the canal and predicts failure

bull In Lateral BPPV nystagmus should beat towards the

good ear

Sixth Annual Intensive Update in Neurology 0915-162016

31

Posterior to Lateral canal conversion

Sixth Annual Intensive Update in Neurology 0915-162016

32

R Posterior to Lateral Canal conversion - geotropic

Sixth Annual Intensive Update in Neurology 0915-162016

33

BPPV Recurrence

bull Recurrence is common (15yr)

bull Otoconial adherence or mineralization demineralization

abnormalities may contribute to recurrence

bull Home canalith repositioning is effective (Radke 2004)

Sixth Annual Intensive Update in Neurology 0915-162016

34

Question 1

bull The most likely semicircular canal to be affected in

BPPV is

ndash 1) superior

ndash 2) lateral

ndash 3) posterior

ndash 4) combined

Sixth Annual Intensive Update in Neurology 0915-162016

35

Question 1

bull The most likely semicircular canal to be affected in

BPPV is

ndash 1) superior

ndash 2) lateral

ndash 3) posterior

ndash 4) combined

Answer 3 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

36

Acute Vestibular Syndrome

bull Rapid unilateral injury to either peripheral or central

vestibular structures produces prolonged vertigo

(days to weeks)

bull Severe vertigo nausea and vomiting spontaneous

nystagmus and postural instability

Sixth Annual Intensive Update in Neurology 0915-162016

37

Acute Vestibular Syndrome

bull 25 of patients with risk factors who present with isolated severe vertigo nystagmus and postural instability in the ER have an acute infarction of the inferior cerebellum (AICA PICA) Central imaging is suggested (Baloh 1998 NEJM)

ndash HTN diabetes smoking age gt65 Afib valvular heart disease occlusive vascular disease

Sixth Annual Intensive Update in Neurology 0915-162016

38

HINTS test

bull Head Impulse

bull Nystagmus

bull Test of Skew

ndash More sensitive than MRI in the diagnosis of acute stroke in

patients with acute vestibular syndrome with at least one risk

factor (Kattah J et al Stroke 2009)

Sixth Annual Intensive Update in Neurology 0915-162016

39

Head Impulse Test

bull No special equipment needed

bull Examiner stands in front of seated patient and

randomly moves head left and right Patient is asked to

focus on examinerrsquos nose

bull Rapid low amplitude thrust from lateral to straight

ahead causes a compensatory saccade when

performed towards the weak side

bull This finding is a permanent feature of unilateral

vestibular loss

Sixth Annual Intensive Update in Neurology 0915-162016

40

Head Impulse Test

Sixth Annual Intensive Update in Neurology 0915-162016

41

Head CT ndash Academy of Emergency Medicine 2013

bull The clinical value of head CT in isolated

dizzinessvertigo without any associated neurological

symptoms is very low

bull Less than 1 of head CTs ordered for dizziness and

vertigo have significant abnormalities and those

patients had severe headache and neurological deficits

in addition to dizziness

bull Forgoing unnecessary emergency head CTs could

save 360 million dollars annually

Sixth Annual Intensive Update in Neurology 0915-162016

42

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Sixth Annual Intensive Update in Neurology 0915-162016

43

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Answer 2 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

44

Acute Vestibular Syndrome

bull Usually peripheral and can be associated with

hearing loss (labyrinthitis)

bull Timely diagnosis improves recovery (ASAP

prednisone 1mgkgday for ten days and taper 10

mgday ndash Strupp M 2004 NEJM)

bull Avoid vestibular suppressants after 3 days and begin

vestibular rehabilitation to hasten compensation

Sixth Annual Intensive Update in Neurology 0915-162016

45

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

46

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Answer 5 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

47

Menierersquos syndrome

bull Fluctuating low frequency hearing loss

bull Tinnitus andor aural fullness

bull Vertigo lasting hours

Sixth Annual Intensive Update in Neurology 0915-162016

48

Normal

Sixth Annual Intensive Update in Neurology 0915-162016

49

Hydrops

Sixth Annual Intensive Update in Neurology 0915-162016

50

Menierersquos syndrome

ndash Diagnosis- Exclusion (RO acoustic)

ndash 23 of Menierersquos patients will improve spontaneously

ndash Treatment-1500 mgday low sodium triamterene375-

hydrochlorothiazide 25 vestibular suppressants (lorazepam

1 mg tablet sublingual Q 8 prn attacks) off label use

Sixth Annual Intensive Update in Neurology 0915-162016

51

Menierersquos syndrome ndash intratympanic steroids

ndash A newer treatment option for those failing medical management

ndash 90 response rate (Boleus-Aguirre MS Otology Neurotology

2008)

ndash Outcomes data confirm excellent clinical response in 3941

Menierersquos patients treated with intratympanic steroids in 2008

Sixth Annual Intensive Update in Neurology 0915-162016

52

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

53

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Answer 5 See references at end

Sixth Annual Intensive Update in Neurology 0915-162016

54

Superior Semicircular Canal Dehiscence (SSCD)

bull Sound andor pressure induced oscillopsia

bull CT reformatted in the plane of the superior canals

shows dehiscence of overlying bone

bull Low frequency ldquoconductive hyperacusisrdquo with elevated

bone thresholds normal reflexes and a conductive loss

Sixth Annual Intensive Update in Neurology 0915-162016

55

SSCD

bull Positive middle ear pressure or loud sound stimulates ampullofugal endolymph flow -canal activation

bull Eye movements are tonic upwards with ipsilateral intorsion

Sixth Annual Intensive Update in Neurology 0915-162016

56

SSCD

bull Valsalva against a closed glottis or jugular compression causes increased intracranial pressure and ampullopetal endolymph flow -canal inhibition

bull Eye movements are tonic downwards with ipsilateral extorsion

Sixth Annual Intensive Update in Neurology 0915-162016

57

Reconstructed left superior semicircular canal

Sixth Annual Intensive Update in Neurology 0915-162016

58

Sixth Annual Intensive Update in Neurology 0915-162016

59

SCHEMATIC DRAWING OF AN OTOLITHIC MACULA

Sixth Annual Intensive Update in Neurology 0915-162016

60

MACULAE OF THE UTRICLESACCULE

Sixth Annual Intensive Update in Neurology 0915-162016

61

HAIR CELLS

Sixth Annual Intensive Update in Neurology 0915-162016

62

SCANNING ELECTRON MICROGRAPH OF OTOCONIA

Sixth Annual Intensive Update in Neurology 0915-162016

63

Ocular VEMP

bull Response to loud clicks (80-110 dB) or forehead tap (Halmagyi and Curthoys 2003)

bull Contralateral oculomotor nucleus (CN III)

bull Inferior oblique muscle contraction (8 msec) detected by 5sec event triggered averaging

bull Noninverting electrode inferior to eye

bull Inverting below non-inverting electrode

bull Ground to forehead

bull Normal subjects have very low response

Sixth Annual Intensive Update in Neurology 0915-162016

64

Clinical applications

bull The o-VEMP is a sensitive test of otolithutricular

function

bull Complements vestibular test procedures that assess

semicircular canals

bull Abnormally robust responses are associated with third

window abnormalities such as semicircular canal

dehiscence

bull Serves as an excellent screening test for semicircular

canal dehiscence

Sixth Annual Intensive Update in Neurology 0915-162016

65

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Sixth Annual Intensive Update in Neurology 0915-162016

66

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Answer 1 References at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

67

Enlarged vestibular aqueduct

bull Axial temporal bone CT showing right temporal bone with enlarged vestibular aqueduct (arrow)

bull Vestibular symptoms accompany progressive sensorineural hearing loss in 4-50 of patients in selected series

Sixth Annual Intensive Update in Neurology 0915-162016

68

Migraine

bull Family or personal history of migraine

bull 25 of migraine patients experience spontaneous vertigo (Baloh 1997)

bull Neuhauser criteria(2001) have been used to construct structured diagnostic interviews (Furman 2003)

bull Not always associated with headache

bull Motion sensitivity

bull Medication responsive

Sixth Annual Intensive Update in Neurology 0915-162016

69

ICHD-III beta Criteria for Vestibular Migraine

bull A At least five attacks fulfilling criteria C and D

bull B A current or past history of 11 migraine without aura or 12 migraine with aura

bull C Vestibular symptoms of moderate or severe intensity lasting between 5 minutes and 72 hours

bull D At least 50 associated with one of the following migrainous features

ndash 1 Headaches

ndash 2 Photophobia and phonophobia

ndash 3 Visual Aura

bull E Not better accounted for by another vestibular disorder

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 11: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

11

IncidencePrevalence of BPPV

bull Most common referred diagnosis in tertiary centers

bull 9 of randomly selected community dwelling elderly

(Oghalai JS et al 2000)

bull Incidence increases 38 with each decade of life

(Froehling 1991)

Sixth Annual Intensive Update in Neurology 0915-162016

12

Benign Positional Vertigo (BPPV)

bull Diagnosed with lateral supine head turns and Dix-

Hallpike positioning

ndash Latency

ndash Duration

ndash Fatigue

ndash Habituation

Sixth Annual Intensive Update in Neurology 0915-162016

13

DHT - Sitting

Sixth Annual Intensive Update in Neurology 0915-162016

14

DHT - HHR Orientation

Sixth Annual Intensive Update in Neurology 0915-162016

15

Dix-Hallpike to the Right

Sixth Annual Intensive Update in Neurology 0915-162016

16

Right posterior BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

17

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

18

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

19

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

20

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

21

Canalith Repositioning

bull R posterior

BPPV

CPT 95992

Sixth Annual Intensive Update in Neurology 0915-162016

22

Posterior semicircular canalith repositioning

Sixth Annual Intensive Update in Neurology 0915-162016

23

Supine Positional Tests

Sixth Annual Intensive Update in Neurology 0915-162016

24

Lateral SCC-BPPV

bull Short latency horizontal nystagmus provoked by supine bilateral head turns with prolonged duration and poor fatigability

bull Uncommon (2-15 of total BPPV)

bull Two formsndash Geotropic ndash beating towards undermost ear

ndash Apogeotropic ndash beating away from undermost ear

Sixth Annual Intensive Update in Neurology 0915-162016

25

Geotropic Lateral Canal BPPV

bull Patient is positioned

first to the right lateral

position ndash nystagmus

beats right

bull Patient is then

positioned to the left

lateral position and

nystagmus reverses

and beats left

Sixth Annual Intensive Update in Neurology 0915-162016

26

Left Geotropic Lateral Semicircular Canal BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

27

Repositioning Maneuvers for Geotropic Lateral Semicircular Canal (LSC) BPPV

bull Roll maneuver (Lempert Baloh)

ndash Patient rolls in 90 degree increments towards the good side

completely rolling over R LSC-BPPV repositioning shown

Sixth Annual Intensive Update in Neurology 0915-162016

28

Repositioning Maneuvers for Geotropic LSC BPPV

bull Gufoni maneuver

ndash Patient lies quickly onto good side and turns face-down to

floor for two minutes

Sixth Annual Intensive Update in Neurology 0915-162016

29

Left Apogeotropic LSC BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

30

Nystagmus observed During Repositioning

bull Nystagmus should remain in the same torsional

direction as seen on DHT throughout the treatment of

posterior BPPV

bull Reversal of nystagmus direction suggests the particle

has fallen back into the canal and predicts failure

bull In Lateral BPPV nystagmus should beat towards the

good ear

Sixth Annual Intensive Update in Neurology 0915-162016

31

Posterior to Lateral canal conversion

Sixth Annual Intensive Update in Neurology 0915-162016

32

R Posterior to Lateral Canal conversion - geotropic

Sixth Annual Intensive Update in Neurology 0915-162016

33

BPPV Recurrence

bull Recurrence is common (15yr)

bull Otoconial adherence or mineralization demineralization

abnormalities may contribute to recurrence

bull Home canalith repositioning is effective (Radke 2004)

Sixth Annual Intensive Update in Neurology 0915-162016

34

Question 1

bull The most likely semicircular canal to be affected in

BPPV is

ndash 1) superior

ndash 2) lateral

ndash 3) posterior

ndash 4) combined

Sixth Annual Intensive Update in Neurology 0915-162016

35

Question 1

bull The most likely semicircular canal to be affected in

BPPV is

ndash 1) superior

ndash 2) lateral

ndash 3) posterior

ndash 4) combined

Answer 3 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

36

Acute Vestibular Syndrome

bull Rapid unilateral injury to either peripheral or central

vestibular structures produces prolonged vertigo

(days to weeks)

bull Severe vertigo nausea and vomiting spontaneous

nystagmus and postural instability

Sixth Annual Intensive Update in Neurology 0915-162016

37

Acute Vestibular Syndrome

bull 25 of patients with risk factors who present with isolated severe vertigo nystagmus and postural instability in the ER have an acute infarction of the inferior cerebellum (AICA PICA) Central imaging is suggested (Baloh 1998 NEJM)

ndash HTN diabetes smoking age gt65 Afib valvular heart disease occlusive vascular disease

Sixth Annual Intensive Update in Neurology 0915-162016

38

HINTS test

bull Head Impulse

bull Nystagmus

bull Test of Skew

ndash More sensitive than MRI in the diagnosis of acute stroke in

patients with acute vestibular syndrome with at least one risk

factor (Kattah J et al Stroke 2009)

Sixth Annual Intensive Update in Neurology 0915-162016

39

Head Impulse Test

bull No special equipment needed

bull Examiner stands in front of seated patient and

randomly moves head left and right Patient is asked to

focus on examinerrsquos nose

bull Rapid low amplitude thrust from lateral to straight

ahead causes a compensatory saccade when

performed towards the weak side

bull This finding is a permanent feature of unilateral

vestibular loss

Sixth Annual Intensive Update in Neurology 0915-162016

40

Head Impulse Test

Sixth Annual Intensive Update in Neurology 0915-162016

41

Head CT ndash Academy of Emergency Medicine 2013

bull The clinical value of head CT in isolated

dizzinessvertigo without any associated neurological

symptoms is very low

bull Less than 1 of head CTs ordered for dizziness and

vertigo have significant abnormalities and those

patients had severe headache and neurological deficits

in addition to dizziness

bull Forgoing unnecessary emergency head CTs could

save 360 million dollars annually

Sixth Annual Intensive Update in Neurology 0915-162016

42

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Sixth Annual Intensive Update in Neurology 0915-162016

43

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Answer 2 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

44

Acute Vestibular Syndrome

bull Usually peripheral and can be associated with

hearing loss (labyrinthitis)

bull Timely diagnosis improves recovery (ASAP

prednisone 1mgkgday for ten days and taper 10

mgday ndash Strupp M 2004 NEJM)

bull Avoid vestibular suppressants after 3 days and begin

vestibular rehabilitation to hasten compensation

Sixth Annual Intensive Update in Neurology 0915-162016

45

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

46

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Answer 5 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

47

Menierersquos syndrome

bull Fluctuating low frequency hearing loss

bull Tinnitus andor aural fullness

bull Vertigo lasting hours

Sixth Annual Intensive Update in Neurology 0915-162016

48

Normal

Sixth Annual Intensive Update in Neurology 0915-162016

49

Hydrops

Sixth Annual Intensive Update in Neurology 0915-162016

50

Menierersquos syndrome

ndash Diagnosis- Exclusion (RO acoustic)

ndash 23 of Menierersquos patients will improve spontaneously

ndash Treatment-1500 mgday low sodium triamterene375-

hydrochlorothiazide 25 vestibular suppressants (lorazepam

1 mg tablet sublingual Q 8 prn attacks) off label use

Sixth Annual Intensive Update in Neurology 0915-162016

51

Menierersquos syndrome ndash intratympanic steroids

ndash A newer treatment option for those failing medical management

ndash 90 response rate (Boleus-Aguirre MS Otology Neurotology

2008)

ndash Outcomes data confirm excellent clinical response in 3941

Menierersquos patients treated with intratympanic steroids in 2008

Sixth Annual Intensive Update in Neurology 0915-162016

52

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

53

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Answer 5 See references at end

Sixth Annual Intensive Update in Neurology 0915-162016

54

Superior Semicircular Canal Dehiscence (SSCD)

bull Sound andor pressure induced oscillopsia

bull CT reformatted in the plane of the superior canals

shows dehiscence of overlying bone

bull Low frequency ldquoconductive hyperacusisrdquo with elevated

bone thresholds normal reflexes and a conductive loss

Sixth Annual Intensive Update in Neurology 0915-162016

55

SSCD

bull Positive middle ear pressure or loud sound stimulates ampullofugal endolymph flow -canal activation

bull Eye movements are tonic upwards with ipsilateral intorsion

Sixth Annual Intensive Update in Neurology 0915-162016

56

SSCD

bull Valsalva against a closed glottis or jugular compression causes increased intracranial pressure and ampullopetal endolymph flow -canal inhibition

bull Eye movements are tonic downwards with ipsilateral extorsion

Sixth Annual Intensive Update in Neurology 0915-162016

57

Reconstructed left superior semicircular canal

Sixth Annual Intensive Update in Neurology 0915-162016

58

Sixth Annual Intensive Update in Neurology 0915-162016

59

SCHEMATIC DRAWING OF AN OTOLITHIC MACULA

Sixth Annual Intensive Update in Neurology 0915-162016

60

MACULAE OF THE UTRICLESACCULE

Sixth Annual Intensive Update in Neurology 0915-162016

61

HAIR CELLS

Sixth Annual Intensive Update in Neurology 0915-162016

62

SCANNING ELECTRON MICROGRAPH OF OTOCONIA

Sixth Annual Intensive Update in Neurology 0915-162016

63

Ocular VEMP

bull Response to loud clicks (80-110 dB) or forehead tap (Halmagyi and Curthoys 2003)

bull Contralateral oculomotor nucleus (CN III)

bull Inferior oblique muscle contraction (8 msec) detected by 5sec event triggered averaging

bull Noninverting electrode inferior to eye

bull Inverting below non-inverting electrode

bull Ground to forehead

bull Normal subjects have very low response

Sixth Annual Intensive Update in Neurology 0915-162016

64

Clinical applications

bull The o-VEMP is a sensitive test of otolithutricular

function

bull Complements vestibular test procedures that assess

semicircular canals

bull Abnormally robust responses are associated with third

window abnormalities such as semicircular canal

dehiscence

bull Serves as an excellent screening test for semicircular

canal dehiscence

Sixth Annual Intensive Update in Neurology 0915-162016

65

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Sixth Annual Intensive Update in Neurology 0915-162016

66

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Answer 1 References at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

67

Enlarged vestibular aqueduct

bull Axial temporal bone CT showing right temporal bone with enlarged vestibular aqueduct (arrow)

bull Vestibular symptoms accompany progressive sensorineural hearing loss in 4-50 of patients in selected series

Sixth Annual Intensive Update in Neurology 0915-162016

68

Migraine

bull Family or personal history of migraine

bull 25 of migraine patients experience spontaneous vertigo (Baloh 1997)

bull Neuhauser criteria(2001) have been used to construct structured diagnostic interviews (Furman 2003)

bull Not always associated with headache

bull Motion sensitivity

bull Medication responsive

Sixth Annual Intensive Update in Neurology 0915-162016

69

ICHD-III beta Criteria for Vestibular Migraine

bull A At least five attacks fulfilling criteria C and D

bull B A current or past history of 11 migraine without aura or 12 migraine with aura

bull C Vestibular symptoms of moderate or severe intensity lasting between 5 minutes and 72 hours

bull D At least 50 associated with one of the following migrainous features

ndash 1 Headaches

ndash 2 Photophobia and phonophobia

ndash 3 Visual Aura

bull E Not better accounted for by another vestibular disorder

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 12: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

12

Benign Positional Vertigo (BPPV)

bull Diagnosed with lateral supine head turns and Dix-

Hallpike positioning

ndash Latency

ndash Duration

ndash Fatigue

ndash Habituation

Sixth Annual Intensive Update in Neurology 0915-162016

13

DHT - Sitting

Sixth Annual Intensive Update in Neurology 0915-162016

14

DHT - HHR Orientation

Sixth Annual Intensive Update in Neurology 0915-162016

15

Dix-Hallpike to the Right

Sixth Annual Intensive Update in Neurology 0915-162016

16

Right posterior BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

17

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

18

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

19

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

20

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

21

Canalith Repositioning

bull R posterior

BPPV

CPT 95992

Sixth Annual Intensive Update in Neurology 0915-162016

22

Posterior semicircular canalith repositioning

Sixth Annual Intensive Update in Neurology 0915-162016

23

Supine Positional Tests

Sixth Annual Intensive Update in Neurology 0915-162016

24

Lateral SCC-BPPV

bull Short latency horizontal nystagmus provoked by supine bilateral head turns with prolonged duration and poor fatigability

bull Uncommon (2-15 of total BPPV)

bull Two formsndash Geotropic ndash beating towards undermost ear

ndash Apogeotropic ndash beating away from undermost ear

Sixth Annual Intensive Update in Neurology 0915-162016

25

Geotropic Lateral Canal BPPV

bull Patient is positioned

first to the right lateral

position ndash nystagmus

beats right

bull Patient is then

positioned to the left

lateral position and

nystagmus reverses

and beats left

Sixth Annual Intensive Update in Neurology 0915-162016

26

Left Geotropic Lateral Semicircular Canal BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

27

Repositioning Maneuvers for Geotropic Lateral Semicircular Canal (LSC) BPPV

bull Roll maneuver (Lempert Baloh)

ndash Patient rolls in 90 degree increments towards the good side

completely rolling over R LSC-BPPV repositioning shown

Sixth Annual Intensive Update in Neurology 0915-162016

28

Repositioning Maneuvers for Geotropic LSC BPPV

bull Gufoni maneuver

ndash Patient lies quickly onto good side and turns face-down to

floor for two minutes

Sixth Annual Intensive Update in Neurology 0915-162016

29

Left Apogeotropic LSC BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

30

Nystagmus observed During Repositioning

bull Nystagmus should remain in the same torsional

direction as seen on DHT throughout the treatment of

posterior BPPV

bull Reversal of nystagmus direction suggests the particle

has fallen back into the canal and predicts failure

bull In Lateral BPPV nystagmus should beat towards the

good ear

Sixth Annual Intensive Update in Neurology 0915-162016

31

Posterior to Lateral canal conversion

Sixth Annual Intensive Update in Neurology 0915-162016

32

R Posterior to Lateral Canal conversion - geotropic

Sixth Annual Intensive Update in Neurology 0915-162016

33

BPPV Recurrence

bull Recurrence is common (15yr)

bull Otoconial adherence or mineralization demineralization

abnormalities may contribute to recurrence

bull Home canalith repositioning is effective (Radke 2004)

Sixth Annual Intensive Update in Neurology 0915-162016

34

Question 1

bull The most likely semicircular canal to be affected in

BPPV is

ndash 1) superior

ndash 2) lateral

ndash 3) posterior

ndash 4) combined

Sixth Annual Intensive Update in Neurology 0915-162016

35

Question 1

bull The most likely semicircular canal to be affected in

BPPV is

ndash 1) superior

ndash 2) lateral

ndash 3) posterior

ndash 4) combined

Answer 3 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

36

Acute Vestibular Syndrome

bull Rapid unilateral injury to either peripheral or central

vestibular structures produces prolonged vertigo

(days to weeks)

bull Severe vertigo nausea and vomiting spontaneous

nystagmus and postural instability

Sixth Annual Intensive Update in Neurology 0915-162016

37

Acute Vestibular Syndrome

bull 25 of patients with risk factors who present with isolated severe vertigo nystagmus and postural instability in the ER have an acute infarction of the inferior cerebellum (AICA PICA) Central imaging is suggested (Baloh 1998 NEJM)

ndash HTN diabetes smoking age gt65 Afib valvular heart disease occlusive vascular disease

Sixth Annual Intensive Update in Neurology 0915-162016

38

HINTS test

bull Head Impulse

bull Nystagmus

bull Test of Skew

ndash More sensitive than MRI in the diagnosis of acute stroke in

patients with acute vestibular syndrome with at least one risk

factor (Kattah J et al Stroke 2009)

Sixth Annual Intensive Update in Neurology 0915-162016

39

Head Impulse Test

bull No special equipment needed

bull Examiner stands in front of seated patient and

randomly moves head left and right Patient is asked to

focus on examinerrsquos nose

bull Rapid low amplitude thrust from lateral to straight

ahead causes a compensatory saccade when

performed towards the weak side

bull This finding is a permanent feature of unilateral

vestibular loss

Sixth Annual Intensive Update in Neurology 0915-162016

40

Head Impulse Test

Sixth Annual Intensive Update in Neurology 0915-162016

41

Head CT ndash Academy of Emergency Medicine 2013

bull The clinical value of head CT in isolated

dizzinessvertigo without any associated neurological

symptoms is very low

bull Less than 1 of head CTs ordered for dizziness and

vertigo have significant abnormalities and those

patients had severe headache and neurological deficits

in addition to dizziness

bull Forgoing unnecessary emergency head CTs could

save 360 million dollars annually

Sixth Annual Intensive Update in Neurology 0915-162016

42

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Sixth Annual Intensive Update in Neurology 0915-162016

43

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Answer 2 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

44

Acute Vestibular Syndrome

bull Usually peripheral and can be associated with

hearing loss (labyrinthitis)

bull Timely diagnosis improves recovery (ASAP

prednisone 1mgkgday for ten days and taper 10

mgday ndash Strupp M 2004 NEJM)

bull Avoid vestibular suppressants after 3 days and begin

vestibular rehabilitation to hasten compensation

Sixth Annual Intensive Update in Neurology 0915-162016

45

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

46

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Answer 5 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

47

Menierersquos syndrome

bull Fluctuating low frequency hearing loss

bull Tinnitus andor aural fullness

bull Vertigo lasting hours

Sixth Annual Intensive Update in Neurology 0915-162016

48

Normal

Sixth Annual Intensive Update in Neurology 0915-162016

49

Hydrops

Sixth Annual Intensive Update in Neurology 0915-162016

50

Menierersquos syndrome

ndash Diagnosis- Exclusion (RO acoustic)

ndash 23 of Menierersquos patients will improve spontaneously

ndash Treatment-1500 mgday low sodium triamterene375-

hydrochlorothiazide 25 vestibular suppressants (lorazepam

1 mg tablet sublingual Q 8 prn attacks) off label use

Sixth Annual Intensive Update in Neurology 0915-162016

51

Menierersquos syndrome ndash intratympanic steroids

ndash A newer treatment option for those failing medical management

ndash 90 response rate (Boleus-Aguirre MS Otology Neurotology

2008)

ndash Outcomes data confirm excellent clinical response in 3941

Menierersquos patients treated with intratympanic steroids in 2008

Sixth Annual Intensive Update in Neurology 0915-162016

52

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

53

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Answer 5 See references at end

Sixth Annual Intensive Update in Neurology 0915-162016

54

Superior Semicircular Canal Dehiscence (SSCD)

bull Sound andor pressure induced oscillopsia

bull CT reformatted in the plane of the superior canals

shows dehiscence of overlying bone

bull Low frequency ldquoconductive hyperacusisrdquo with elevated

bone thresholds normal reflexes and a conductive loss

Sixth Annual Intensive Update in Neurology 0915-162016

55

SSCD

bull Positive middle ear pressure or loud sound stimulates ampullofugal endolymph flow -canal activation

bull Eye movements are tonic upwards with ipsilateral intorsion

Sixth Annual Intensive Update in Neurology 0915-162016

56

SSCD

bull Valsalva against a closed glottis or jugular compression causes increased intracranial pressure and ampullopetal endolymph flow -canal inhibition

bull Eye movements are tonic downwards with ipsilateral extorsion

Sixth Annual Intensive Update in Neurology 0915-162016

57

Reconstructed left superior semicircular canal

Sixth Annual Intensive Update in Neurology 0915-162016

58

Sixth Annual Intensive Update in Neurology 0915-162016

59

SCHEMATIC DRAWING OF AN OTOLITHIC MACULA

Sixth Annual Intensive Update in Neurology 0915-162016

60

MACULAE OF THE UTRICLESACCULE

Sixth Annual Intensive Update in Neurology 0915-162016

61

HAIR CELLS

Sixth Annual Intensive Update in Neurology 0915-162016

62

SCANNING ELECTRON MICROGRAPH OF OTOCONIA

Sixth Annual Intensive Update in Neurology 0915-162016

63

Ocular VEMP

bull Response to loud clicks (80-110 dB) or forehead tap (Halmagyi and Curthoys 2003)

bull Contralateral oculomotor nucleus (CN III)

bull Inferior oblique muscle contraction (8 msec) detected by 5sec event triggered averaging

bull Noninverting electrode inferior to eye

bull Inverting below non-inverting electrode

bull Ground to forehead

bull Normal subjects have very low response

Sixth Annual Intensive Update in Neurology 0915-162016

64

Clinical applications

bull The o-VEMP is a sensitive test of otolithutricular

function

bull Complements vestibular test procedures that assess

semicircular canals

bull Abnormally robust responses are associated with third

window abnormalities such as semicircular canal

dehiscence

bull Serves as an excellent screening test for semicircular

canal dehiscence

Sixth Annual Intensive Update in Neurology 0915-162016

65

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Sixth Annual Intensive Update in Neurology 0915-162016

66

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Answer 1 References at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

67

Enlarged vestibular aqueduct

bull Axial temporal bone CT showing right temporal bone with enlarged vestibular aqueduct (arrow)

bull Vestibular symptoms accompany progressive sensorineural hearing loss in 4-50 of patients in selected series

Sixth Annual Intensive Update in Neurology 0915-162016

68

Migraine

bull Family or personal history of migraine

bull 25 of migraine patients experience spontaneous vertigo (Baloh 1997)

bull Neuhauser criteria(2001) have been used to construct structured diagnostic interviews (Furman 2003)

bull Not always associated with headache

bull Motion sensitivity

bull Medication responsive

Sixth Annual Intensive Update in Neurology 0915-162016

69

ICHD-III beta Criteria for Vestibular Migraine

bull A At least five attacks fulfilling criteria C and D

bull B A current or past history of 11 migraine without aura or 12 migraine with aura

bull C Vestibular symptoms of moderate or severe intensity lasting between 5 minutes and 72 hours

bull D At least 50 associated with one of the following migrainous features

ndash 1 Headaches

ndash 2 Photophobia and phonophobia

ndash 3 Visual Aura

bull E Not better accounted for by another vestibular disorder

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 13: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

13

DHT - Sitting

Sixth Annual Intensive Update in Neurology 0915-162016

14

DHT - HHR Orientation

Sixth Annual Intensive Update in Neurology 0915-162016

15

Dix-Hallpike to the Right

Sixth Annual Intensive Update in Neurology 0915-162016

16

Right posterior BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

17

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

18

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

19

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

20

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

21

Canalith Repositioning

bull R posterior

BPPV

CPT 95992

Sixth Annual Intensive Update in Neurology 0915-162016

22

Posterior semicircular canalith repositioning

Sixth Annual Intensive Update in Neurology 0915-162016

23

Supine Positional Tests

Sixth Annual Intensive Update in Neurology 0915-162016

24

Lateral SCC-BPPV

bull Short latency horizontal nystagmus provoked by supine bilateral head turns with prolonged duration and poor fatigability

bull Uncommon (2-15 of total BPPV)

bull Two formsndash Geotropic ndash beating towards undermost ear

ndash Apogeotropic ndash beating away from undermost ear

Sixth Annual Intensive Update in Neurology 0915-162016

25

Geotropic Lateral Canal BPPV

bull Patient is positioned

first to the right lateral

position ndash nystagmus

beats right

bull Patient is then

positioned to the left

lateral position and

nystagmus reverses

and beats left

Sixth Annual Intensive Update in Neurology 0915-162016

26

Left Geotropic Lateral Semicircular Canal BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

27

Repositioning Maneuvers for Geotropic Lateral Semicircular Canal (LSC) BPPV

bull Roll maneuver (Lempert Baloh)

ndash Patient rolls in 90 degree increments towards the good side

completely rolling over R LSC-BPPV repositioning shown

Sixth Annual Intensive Update in Neurology 0915-162016

28

Repositioning Maneuvers for Geotropic LSC BPPV

bull Gufoni maneuver

ndash Patient lies quickly onto good side and turns face-down to

floor for two minutes

Sixth Annual Intensive Update in Neurology 0915-162016

29

Left Apogeotropic LSC BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

30

Nystagmus observed During Repositioning

bull Nystagmus should remain in the same torsional

direction as seen on DHT throughout the treatment of

posterior BPPV

bull Reversal of nystagmus direction suggests the particle

has fallen back into the canal and predicts failure

bull In Lateral BPPV nystagmus should beat towards the

good ear

Sixth Annual Intensive Update in Neurology 0915-162016

31

Posterior to Lateral canal conversion

Sixth Annual Intensive Update in Neurology 0915-162016

32

R Posterior to Lateral Canal conversion - geotropic

Sixth Annual Intensive Update in Neurology 0915-162016

33

BPPV Recurrence

bull Recurrence is common (15yr)

bull Otoconial adherence or mineralization demineralization

abnormalities may contribute to recurrence

bull Home canalith repositioning is effective (Radke 2004)

Sixth Annual Intensive Update in Neurology 0915-162016

34

Question 1

bull The most likely semicircular canal to be affected in

BPPV is

ndash 1) superior

ndash 2) lateral

ndash 3) posterior

ndash 4) combined

Sixth Annual Intensive Update in Neurology 0915-162016

35

Question 1

bull The most likely semicircular canal to be affected in

BPPV is

ndash 1) superior

ndash 2) lateral

ndash 3) posterior

ndash 4) combined

Answer 3 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

36

Acute Vestibular Syndrome

bull Rapid unilateral injury to either peripheral or central

vestibular structures produces prolonged vertigo

(days to weeks)

bull Severe vertigo nausea and vomiting spontaneous

nystagmus and postural instability

Sixth Annual Intensive Update in Neurology 0915-162016

37

Acute Vestibular Syndrome

bull 25 of patients with risk factors who present with isolated severe vertigo nystagmus and postural instability in the ER have an acute infarction of the inferior cerebellum (AICA PICA) Central imaging is suggested (Baloh 1998 NEJM)

ndash HTN diabetes smoking age gt65 Afib valvular heart disease occlusive vascular disease

Sixth Annual Intensive Update in Neurology 0915-162016

38

HINTS test

bull Head Impulse

bull Nystagmus

bull Test of Skew

ndash More sensitive than MRI in the diagnosis of acute stroke in

patients with acute vestibular syndrome with at least one risk

factor (Kattah J et al Stroke 2009)

Sixth Annual Intensive Update in Neurology 0915-162016

39

Head Impulse Test

bull No special equipment needed

bull Examiner stands in front of seated patient and

randomly moves head left and right Patient is asked to

focus on examinerrsquos nose

bull Rapid low amplitude thrust from lateral to straight

ahead causes a compensatory saccade when

performed towards the weak side

bull This finding is a permanent feature of unilateral

vestibular loss

Sixth Annual Intensive Update in Neurology 0915-162016

40

Head Impulse Test

Sixth Annual Intensive Update in Neurology 0915-162016

41

Head CT ndash Academy of Emergency Medicine 2013

bull The clinical value of head CT in isolated

dizzinessvertigo without any associated neurological

symptoms is very low

bull Less than 1 of head CTs ordered for dizziness and

vertigo have significant abnormalities and those

patients had severe headache and neurological deficits

in addition to dizziness

bull Forgoing unnecessary emergency head CTs could

save 360 million dollars annually

Sixth Annual Intensive Update in Neurology 0915-162016

42

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Sixth Annual Intensive Update in Neurology 0915-162016

43

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Answer 2 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

44

Acute Vestibular Syndrome

bull Usually peripheral and can be associated with

hearing loss (labyrinthitis)

bull Timely diagnosis improves recovery (ASAP

prednisone 1mgkgday for ten days and taper 10

mgday ndash Strupp M 2004 NEJM)

bull Avoid vestibular suppressants after 3 days and begin

vestibular rehabilitation to hasten compensation

Sixth Annual Intensive Update in Neurology 0915-162016

45

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

46

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Answer 5 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

47

Menierersquos syndrome

bull Fluctuating low frequency hearing loss

bull Tinnitus andor aural fullness

bull Vertigo lasting hours

Sixth Annual Intensive Update in Neurology 0915-162016

48

Normal

Sixth Annual Intensive Update in Neurology 0915-162016

49

Hydrops

Sixth Annual Intensive Update in Neurology 0915-162016

50

Menierersquos syndrome

ndash Diagnosis- Exclusion (RO acoustic)

ndash 23 of Menierersquos patients will improve spontaneously

ndash Treatment-1500 mgday low sodium triamterene375-

hydrochlorothiazide 25 vestibular suppressants (lorazepam

1 mg tablet sublingual Q 8 prn attacks) off label use

Sixth Annual Intensive Update in Neurology 0915-162016

51

Menierersquos syndrome ndash intratympanic steroids

ndash A newer treatment option for those failing medical management

ndash 90 response rate (Boleus-Aguirre MS Otology Neurotology

2008)

ndash Outcomes data confirm excellent clinical response in 3941

Menierersquos patients treated with intratympanic steroids in 2008

Sixth Annual Intensive Update in Neurology 0915-162016

52

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

53

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Answer 5 See references at end

Sixth Annual Intensive Update in Neurology 0915-162016

54

Superior Semicircular Canal Dehiscence (SSCD)

bull Sound andor pressure induced oscillopsia

bull CT reformatted in the plane of the superior canals

shows dehiscence of overlying bone

bull Low frequency ldquoconductive hyperacusisrdquo with elevated

bone thresholds normal reflexes and a conductive loss

Sixth Annual Intensive Update in Neurology 0915-162016

55

SSCD

bull Positive middle ear pressure or loud sound stimulates ampullofugal endolymph flow -canal activation

bull Eye movements are tonic upwards with ipsilateral intorsion

Sixth Annual Intensive Update in Neurology 0915-162016

56

SSCD

bull Valsalva against a closed glottis or jugular compression causes increased intracranial pressure and ampullopetal endolymph flow -canal inhibition

bull Eye movements are tonic downwards with ipsilateral extorsion

Sixth Annual Intensive Update in Neurology 0915-162016

57

Reconstructed left superior semicircular canal

Sixth Annual Intensive Update in Neurology 0915-162016

58

Sixth Annual Intensive Update in Neurology 0915-162016

59

SCHEMATIC DRAWING OF AN OTOLITHIC MACULA

Sixth Annual Intensive Update in Neurology 0915-162016

60

MACULAE OF THE UTRICLESACCULE

Sixth Annual Intensive Update in Neurology 0915-162016

61

HAIR CELLS

Sixth Annual Intensive Update in Neurology 0915-162016

62

SCANNING ELECTRON MICROGRAPH OF OTOCONIA

Sixth Annual Intensive Update in Neurology 0915-162016

63

Ocular VEMP

bull Response to loud clicks (80-110 dB) or forehead tap (Halmagyi and Curthoys 2003)

bull Contralateral oculomotor nucleus (CN III)

bull Inferior oblique muscle contraction (8 msec) detected by 5sec event triggered averaging

bull Noninverting electrode inferior to eye

bull Inverting below non-inverting electrode

bull Ground to forehead

bull Normal subjects have very low response

Sixth Annual Intensive Update in Neurology 0915-162016

64

Clinical applications

bull The o-VEMP is a sensitive test of otolithutricular

function

bull Complements vestibular test procedures that assess

semicircular canals

bull Abnormally robust responses are associated with third

window abnormalities such as semicircular canal

dehiscence

bull Serves as an excellent screening test for semicircular

canal dehiscence

Sixth Annual Intensive Update in Neurology 0915-162016

65

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Sixth Annual Intensive Update in Neurology 0915-162016

66

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Answer 1 References at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

67

Enlarged vestibular aqueduct

bull Axial temporal bone CT showing right temporal bone with enlarged vestibular aqueduct (arrow)

bull Vestibular symptoms accompany progressive sensorineural hearing loss in 4-50 of patients in selected series

Sixth Annual Intensive Update in Neurology 0915-162016

68

Migraine

bull Family or personal history of migraine

bull 25 of migraine patients experience spontaneous vertigo (Baloh 1997)

bull Neuhauser criteria(2001) have been used to construct structured diagnostic interviews (Furman 2003)

bull Not always associated with headache

bull Motion sensitivity

bull Medication responsive

Sixth Annual Intensive Update in Neurology 0915-162016

69

ICHD-III beta Criteria for Vestibular Migraine

bull A At least five attacks fulfilling criteria C and D

bull B A current or past history of 11 migraine without aura or 12 migraine with aura

bull C Vestibular symptoms of moderate or severe intensity lasting between 5 minutes and 72 hours

bull D At least 50 associated with one of the following migrainous features

ndash 1 Headaches

ndash 2 Photophobia and phonophobia

ndash 3 Visual Aura

bull E Not better accounted for by another vestibular disorder

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 14: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

14

DHT - HHR Orientation

Sixth Annual Intensive Update in Neurology 0915-162016

15

Dix-Hallpike to the Right

Sixth Annual Intensive Update in Neurology 0915-162016

16

Right posterior BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

17

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

18

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

19

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

20

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

21

Canalith Repositioning

bull R posterior

BPPV

CPT 95992

Sixth Annual Intensive Update in Neurology 0915-162016

22

Posterior semicircular canalith repositioning

Sixth Annual Intensive Update in Neurology 0915-162016

23

Supine Positional Tests

Sixth Annual Intensive Update in Neurology 0915-162016

24

Lateral SCC-BPPV

bull Short latency horizontal nystagmus provoked by supine bilateral head turns with prolonged duration and poor fatigability

bull Uncommon (2-15 of total BPPV)

bull Two formsndash Geotropic ndash beating towards undermost ear

ndash Apogeotropic ndash beating away from undermost ear

Sixth Annual Intensive Update in Neurology 0915-162016

25

Geotropic Lateral Canal BPPV

bull Patient is positioned

first to the right lateral

position ndash nystagmus

beats right

bull Patient is then

positioned to the left

lateral position and

nystagmus reverses

and beats left

Sixth Annual Intensive Update in Neurology 0915-162016

26

Left Geotropic Lateral Semicircular Canal BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

27

Repositioning Maneuvers for Geotropic Lateral Semicircular Canal (LSC) BPPV

bull Roll maneuver (Lempert Baloh)

ndash Patient rolls in 90 degree increments towards the good side

completely rolling over R LSC-BPPV repositioning shown

Sixth Annual Intensive Update in Neurology 0915-162016

28

Repositioning Maneuvers for Geotropic LSC BPPV

bull Gufoni maneuver

ndash Patient lies quickly onto good side and turns face-down to

floor for two minutes

Sixth Annual Intensive Update in Neurology 0915-162016

29

Left Apogeotropic LSC BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

30

Nystagmus observed During Repositioning

bull Nystagmus should remain in the same torsional

direction as seen on DHT throughout the treatment of

posterior BPPV

bull Reversal of nystagmus direction suggests the particle

has fallen back into the canal and predicts failure

bull In Lateral BPPV nystagmus should beat towards the

good ear

Sixth Annual Intensive Update in Neurology 0915-162016

31

Posterior to Lateral canal conversion

Sixth Annual Intensive Update in Neurology 0915-162016

32

R Posterior to Lateral Canal conversion - geotropic

Sixth Annual Intensive Update in Neurology 0915-162016

33

BPPV Recurrence

bull Recurrence is common (15yr)

bull Otoconial adherence or mineralization demineralization

abnormalities may contribute to recurrence

bull Home canalith repositioning is effective (Radke 2004)

Sixth Annual Intensive Update in Neurology 0915-162016

34

Question 1

bull The most likely semicircular canal to be affected in

BPPV is

ndash 1) superior

ndash 2) lateral

ndash 3) posterior

ndash 4) combined

Sixth Annual Intensive Update in Neurology 0915-162016

35

Question 1

bull The most likely semicircular canal to be affected in

BPPV is

ndash 1) superior

ndash 2) lateral

ndash 3) posterior

ndash 4) combined

Answer 3 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

36

Acute Vestibular Syndrome

bull Rapid unilateral injury to either peripheral or central

vestibular structures produces prolonged vertigo

(days to weeks)

bull Severe vertigo nausea and vomiting spontaneous

nystagmus and postural instability

Sixth Annual Intensive Update in Neurology 0915-162016

37

Acute Vestibular Syndrome

bull 25 of patients with risk factors who present with isolated severe vertigo nystagmus and postural instability in the ER have an acute infarction of the inferior cerebellum (AICA PICA) Central imaging is suggested (Baloh 1998 NEJM)

ndash HTN diabetes smoking age gt65 Afib valvular heart disease occlusive vascular disease

Sixth Annual Intensive Update in Neurology 0915-162016

38

HINTS test

bull Head Impulse

bull Nystagmus

bull Test of Skew

ndash More sensitive than MRI in the diagnosis of acute stroke in

patients with acute vestibular syndrome with at least one risk

factor (Kattah J et al Stroke 2009)

Sixth Annual Intensive Update in Neurology 0915-162016

39

Head Impulse Test

bull No special equipment needed

bull Examiner stands in front of seated patient and

randomly moves head left and right Patient is asked to

focus on examinerrsquos nose

bull Rapid low amplitude thrust from lateral to straight

ahead causes a compensatory saccade when

performed towards the weak side

bull This finding is a permanent feature of unilateral

vestibular loss

Sixth Annual Intensive Update in Neurology 0915-162016

40

Head Impulse Test

Sixth Annual Intensive Update in Neurology 0915-162016

41

Head CT ndash Academy of Emergency Medicine 2013

bull The clinical value of head CT in isolated

dizzinessvertigo without any associated neurological

symptoms is very low

bull Less than 1 of head CTs ordered for dizziness and

vertigo have significant abnormalities and those

patients had severe headache and neurological deficits

in addition to dizziness

bull Forgoing unnecessary emergency head CTs could

save 360 million dollars annually

Sixth Annual Intensive Update in Neurology 0915-162016

42

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Sixth Annual Intensive Update in Neurology 0915-162016

43

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Answer 2 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

44

Acute Vestibular Syndrome

bull Usually peripheral and can be associated with

hearing loss (labyrinthitis)

bull Timely diagnosis improves recovery (ASAP

prednisone 1mgkgday for ten days and taper 10

mgday ndash Strupp M 2004 NEJM)

bull Avoid vestibular suppressants after 3 days and begin

vestibular rehabilitation to hasten compensation

Sixth Annual Intensive Update in Neurology 0915-162016

45

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

46

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Answer 5 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

47

Menierersquos syndrome

bull Fluctuating low frequency hearing loss

bull Tinnitus andor aural fullness

bull Vertigo lasting hours

Sixth Annual Intensive Update in Neurology 0915-162016

48

Normal

Sixth Annual Intensive Update in Neurology 0915-162016

49

Hydrops

Sixth Annual Intensive Update in Neurology 0915-162016

50

Menierersquos syndrome

ndash Diagnosis- Exclusion (RO acoustic)

ndash 23 of Menierersquos patients will improve spontaneously

ndash Treatment-1500 mgday low sodium triamterene375-

hydrochlorothiazide 25 vestibular suppressants (lorazepam

1 mg tablet sublingual Q 8 prn attacks) off label use

Sixth Annual Intensive Update in Neurology 0915-162016

51

Menierersquos syndrome ndash intratympanic steroids

ndash A newer treatment option for those failing medical management

ndash 90 response rate (Boleus-Aguirre MS Otology Neurotology

2008)

ndash Outcomes data confirm excellent clinical response in 3941

Menierersquos patients treated with intratympanic steroids in 2008

Sixth Annual Intensive Update in Neurology 0915-162016

52

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

53

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Answer 5 See references at end

Sixth Annual Intensive Update in Neurology 0915-162016

54

Superior Semicircular Canal Dehiscence (SSCD)

bull Sound andor pressure induced oscillopsia

bull CT reformatted in the plane of the superior canals

shows dehiscence of overlying bone

bull Low frequency ldquoconductive hyperacusisrdquo with elevated

bone thresholds normal reflexes and a conductive loss

Sixth Annual Intensive Update in Neurology 0915-162016

55

SSCD

bull Positive middle ear pressure or loud sound stimulates ampullofugal endolymph flow -canal activation

bull Eye movements are tonic upwards with ipsilateral intorsion

Sixth Annual Intensive Update in Neurology 0915-162016

56

SSCD

bull Valsalva against a closed glottis or jugular compression causes increased intracranial pressure and ampullopetal endolymph flow -canal inhibition

bull Eye movements are tonic downwards with ipsilateral extorsion

Sixth Annual Intensive Update in Neurology 0915-162016

57

Reconstructed left superior semicircular canal

Sixth Annual Intensive Update in Neurology 0915-162016

58

Sixth Annual Intensive Update in Neurology 0915-162016

59

SCHEMATIC DRAWING OF AN OTOLITHIC MACULA

Sixth Annual Intensive Update in Neurology 0915-162016

60

MACULAE OF THE UTRICLESACCULE

Sixth Annual Intensive Update in Neurology 0915-162016

61

HAIR CELLS

Sixth Annual Intensive Update in Neurology 0915-162016

62

SCANNING ELECTRON MICROGRAPH OF OTOCONIA

Sixth Annual Intensive Update in Neurology 0915-162016

63

Ocular VEMP

bull Response to loud clicks (80-110 dB) or forehead tap (Halmagyi and Curthoys 2003)

bull Contralateral oculomotor nucleus (CN III)

bull Inferior oblique muscle contraction (8 msec) detected by 5sec event triggered averaging

bull Noninverting electrode inferior to eye

bull Inverting below non-inverting electrode

bull Ground to forehead

bull Normal subjects have very low response

Sixth Annual Intensive Update in Neurology 0915-162016

64

Clinical applications

bull The o-VEMP is a sensitive test of otolithutricular

function

bull Complements vestibular test procedures that assess

semicircular canals

bull Abnormally robust responses are associated with third

window abnormalities such as semicircular canal

dehiscence

bull Serves as an excellent screening test for semicircular

canal dehiscence

Sixth Annual Intensive Update in Neurology 0915-162016

65

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Sixth Annual Intensive Update in Neurology 0915-162016

66

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Answer 1 References at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

67

Enlarged vestibular aqueduct

bull Axial temporal bone CT showing right temporal bone with enlarged vestibular aqueduct (arrow)

bull Vestibular symptoms accompany progressive sensorineural hearing loss in 4-50 of patients in selected series

Sixth Annual Intensive Update in Neurology 0915-162016

68

Migraine

bull Family or personal history of migraine

bull 25 of migraine patients experience spontaneous vertigo (Baloh 1997)

bull Neuhauser criteria(2001) have been used to construct structured diagnostic interviews (Furman 2003)

bull Not always associated with headache

bull Motion sensitivity

bull Medication responsive

Sixth Annual Intensive Update in Neurology 0915-162016

69

ICHD-III beta Criteria for Vestibular Migraine

bull A At least five attacks fulfilling criteria C and D

bull B A current or past history of 11 migraine without aura or 12 migraine with aura

bull C Vestibular symptoms of moderate or severe intensity lasting between 5 minutes and 72 hours

bull D At least 50 associated with one of the following migrainous features

ndash 1 Headaches

ndash 2 Photophobia and phonophobia

ndash 3 Visual Aura

bull E Not better accounted for by another vestibular disorder

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 15: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

15

Dix-Hallpike to the Right

Sixth Annual Intensive Update in Neurology 0915-162016

16

Right posterior BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

17

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

18

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

19

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

20

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

21

Canalith Repositioning

bull R posterior

BPPV

CPT 95992

Sixth Annual Intensive Update in Neurology 0915-162016

22

Posterior semicircular canalith repositioning

Sixth Annual Intensive Update in Neurology 0915-162016

23

Supine Positional Tests

Sixth Annual Intensive Update in Neurology 0915-162016

24

Lateral SCC-BPPV

bull Short latency horizontal nystagmus provoked by supine bilateral head turns with prolonged duration and poor fatigability

bull Uncommon (2-15 of total BPPV)

bull Two formsndash Geotropic ndash beating towards undermost ear

ndash Apogeotropic ndash beating away from undermost ear

Sixth Annual Intensive Update in Neurology 0915-162016

25

Geotropic Lateral Canal BPPV

bull Patient is positioned

first to the right lateral

position ndash nystagmus

beats right

bull Patient is then

positioned to the left

lateral position and

nystagmus reverses

and beats left

Sixth Annual Intensive Update in Neurology 0915-162016

26

Left Geotropic Lateral Semicircular Canal BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

27

Repositioning Maneuvers for Geotropic Lateral Semicircular Canal (LSC) BPPV

bull Roll maneuver (Lempert Baloh)

ndash Patient rolls in 90 degree increments towards the good side

completely rolling over R LSC-BPPV repositioning shown

Sixth Annual Intensive Update in Neurology 0915-162016

28

Repositioning Maneuvers for Geotropic LSC BPPV

bull Gufoni maneuver

ndash Patient lies quickly onto good side and turns face-down to

floor for two minutes

Sixth Annual Intensive Update in Neurology 0915-162016

29

Left Apogeotropic LSC BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

30

Nystagmus observed During Repositioning

bull Nystagmus should remain in the same torsional

direction as seen on DHT throughout the treatment of

posterior BPPV

bull Reversal of nystagmus direction suggests the particle

has fallen back into the canal and predicts failure

bull In Lateral BPPV nystagmus should beat towards the

good ear

Sixth Annual Intensive Update in Neurology 0915-162016

31

Posterior to Lateral canal conversion

Sixth Annual Intensive Update in Neurology 0915-162016

32

R Posterior to Lateral Canal conversion - geotropic

Sixth Annual Intensive Update in Neurology 0915-162016

33

BPPV Recurrence

bull Recurrence is common (15yr)

bull Otoconial adherence or mineralization demineralization

abnormalities may contribute to recurrence

bull Home canalith repositioning is effective (Radke 2004)

Sixth Annual Intensive Update in Neurology 0915-162016

34

Question 1

bull The most likely semicircular canal to be affected in

BPPV is

ndash 1) superior

ndash 2) lateral

ndash 3) posterior

ndash 4) combined

Sixth Annual Intensive Update in Neurology 0915-162016

35

Question 1

bull The most likely semicircular canal to be affected in

BPPV is

ndash 1) superior

ndash 2) lateral

ndash 3) posterior

ndash 4) combined

Answer 3 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

36

Acute Vestibular Syndrome

bull Rapid unilateral injury to either peripheral or central

vestibular structures produces prolonged vertigo

(days to weeks)

bull Severe vertigo nausea and vomiting spontaneous

nystagmus and postural instability

Sixth Annual Intensive Update in Neurology 0915-162016

37

Acute Vestibular Syndrome

bull 25 of patients with risk factors who present with isolated severe vertigo nystagmus and postural instability in the ER have an acute infarction of the inferior cerebellum (AICA PICA) Central imaging is suggested (Baloh 1998 NEJM)

ndash HTN diabetes smoking age gt65 Afib valvular heart disease occlusive vascular disease

Sixth Annual Intensive Update in Neurology 0915-162016

38

HINTS test

bull Head Impulse

bull Nystagmus

bull Test of Skew

ndash More sensitive than MRI in the diagnosis of acute stroke in

patients with acute vestibular syndrome with at least one risk

factor (Kattah J et al Stroke 2009)

Sixth Annual Intensive Update in Neurology 0915-162016

39

Head Impulse Test

bull No special equipment needed

bull Examiner stands in front of seated patient and

randomly moves head left and right Patient is asked to

focus on examinerrsquos nose

bull Rapid low amplitude thrust from lateral to straight

ahead causes a compensatory saccade when

performed towards the weak side

bull This finding is a permanent feature of unilateral

vestibular loss

Sixth Annual Intensive Update in Neurology 0915-162016

40

Head Impulse Test

Sixth Annual Intensive Update in Neurology 0915-162016

41

Head CT ndash Academy of Emergency Medicine 2013

bull The clinical value of head CT in isolated

dizzinessvertigo without any associated neurological

symptoms is very low

bull Less than 1 of head CTs ordered for dizziness and

vertigo have significant abnormalities and those

patients had severe headache and neurological deficits

in addition to dizziness

bull Forgoing unnecessary emergency head CTs could

save 360 million dollars annually

Sixth Annual Intensive Update in Neurology 0915-162016

42

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Sixth Annual Intensive Update in Neurology 0915-162016

43

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Answer 2 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

44

Acute Vestibular Syndrome

bull Usually peripheral and can be associated with

hearing loss (labyrinthitis)

bull Timely diagnosis improves recovery (ASAP

prednisone 1mgkgday for ten days and taper 10

mgday ndash Strupp M 2004 NEJM)

bull Avoid vestibular suppressants after 3 days and begin

vestibular rehabilitation to hasten compensation

Sixth Annual Intensive Update in Neurology 0915-162016

45

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

46

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Answer 5 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

47

Menierersquos syndrome

bull Fluctuating low frequency hearing loss

bull Tinnitus andor aural fullness

bull Vertigo lasting hours

Sixth Annual Intensive Update in Neurology 0915-162016

48

Normal

Sixth Annual Intensive Update in Neurology 0915-162016

49

Hydrops

Sixth Annual Intensive Update in Neurology 0915-162016

50

Menierersquos syndrome

ndash Diagnosis- Exclusion (RO acoustic)

ndash 23 of Menierersquos patients will improve spontaneously

ndash Treatment-1500 mgday low sodium triamterene375-

hydrochlorothiazide 25 vestibular suppressants (lorazepam

1 mg tablet sublingual Q 8 prn attacks) off label use

Sixth Annual Intensive Update in Neurology 0915-162016

51

Menierersquos syndrome ndash intratympanic steroids

ndash A newer treatment option for those failing medical management

ndash 90 response rate (Boleus-Aguirre MS Otology Neurotology

2008)

ndash Outcomes data confirm excellent clinical response in 3941

Menierersquos patients treated with intratympanic steroids in 2008

Sixth Annual Intensive Update in Neurology 0915-162016

52

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

53

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Answer 5 See references at end

Sixth Annual Intensive Update in Neurology 0915-162016

54

Superior Semicircular Canal Dehiscence (SSCD)

bull Sound andor pressure induced oscillopsia

bull CT reformatted in the plane of the superior canals

shows dehiscence of overlying bone

bull Low frequency ldquoconductive hyperacusisrdquo with elevated

bone thresholds normal reflexes and a conductive loss

Sixth Annual Intensive Update in Neurology 0915-162016

55

SSCD

bull Positive middle ear pressure or loud sound stimulates ampullofugal endolymph flow -canal activation

bull Eye movements are tonic upwards with ipsilateral intorsion

Sixth Annual Intensive Update in Neurology 0915-162016

56

SSCD

bull Valsalva against a closed glottis or jugular compression causes increased intracranial pressure and ampullopetal endolymph flow -canal inhibition

bull Eye movements are tonic downwards with ipsilateral extorsion

Sixth Annual Intensive Update in Neurology 0915-162016

57

Reconstructed left superior semicircular canal

Sixth Annual Intensive Update in Neurology 0915-162016

58

Sixth Annual Intensive Update in Neurology 0915-162016

59

SCHEMATIC DRAWING OF AN OTOLITHIC MACULA

Sixth Annual Intensive Update in Neurology 0915-162016

60

MACULAE OF THE UTRICLESACCULE

Sixth Annual Intensive Update in Neurology 0915-162016

61

HAIR CELLS

Sixth Annual Intensive Update in Neurology 0915-162016

62

SCANNING ELECTRON MICROGRAPH OF OTOCONIA

Sixth Annual Intensive Update in Neurology 0915-162016

63

Ocular VEMP

bull Response to loud clicks (80-110 dB) or forehead tap (Halmagyi and Curthoys 2003)

bull Contralateral oculomotor nucleus (CN III)

bull Inferior oblique muscle contraction (8 msec) detected by 5sec event triggered averaging

bull Noninverting electrode inferior to eye

bull Inverting below non-inverting electrode

bull Ground to forehead

bull Normal subjects have very low response

Sixth Annual Intensive Update in Neurology 0915-162016

64

Clinical applications

bull The o-VEMP is a sensitive test of otolithutricular

function

bull Complements vestibular test procedures that assess

semicircular canals

bull Abnormally robust responses are associated with third

window abnormalities such as semicircular canal

dehiscence

bull Serves as an excellent screening test for semicircular

canal dehiscence

Sixth Annual Intensive Update in Neurology 0915-162016

65

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Sixth Annual Intensive Update in Neurology 0915-162016

66

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Answer 1 References at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

67

Enlarged vestibular aqueduct

bull Axial temporal bone CT showing right temporal bone with enlarged vestibular aqueduct (arrow)

bull Vestibular symptoms accompany progressive sensorineural hearing loss in 4-50 of patients in selected series

Sixth Annual Intensive Update in Neurology 0915-162016

68

Migraine

bull Family or personal history of migraine

bull 25 of migraine patients experience spontaneous vertigo (Baloh 1997)

bull Neuhauser criteria(2001) have been used to construct structured diagnostic interviews (Furman 2003)

bull Not always associated with headache

bull Motion sensitivity

bull Medication responsive

Sixth Annual Intensive Update in Neurology 0915-162016

69

ICHD-III beta Criteria for Vestibular Migraine

bull A At least five attacks fulfilling criteria C and D

bull B A current or past history of 11 migraine without aura or 12 migraine with aura

bull C Vestibular symptoms of moderate or severe intensity lasting between 5 minutes and 72 hours

bull D At least 50 associated with one of the following migrainous features

ndash 1 Headaches

ndash 2 Photophobia and phonophobia

ndash 3 Visual Aura

bull E Not better accounted for by another vestibular disorder

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 16: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

16

Right posterior BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

17

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

18

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

19

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

20

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

21

Canalith Repositioning

bull R posterior

BPPV

CPT 95992

Sixth Annual Intensive Update in Neurology 0915-162016

22

Posterior semicircular canalith repositioning

Sixth Annual Intensive Update in Neurology 0915-162016

23

Supine Positional Tests

Sixth Annual Intensive Update in Neurology 0915-162016

24

Lateral SCC-BPPV

bull Short latency horizontal nystagmus provoked by supine bilateral head turns with prolonged duration and poor fatigability

bull Uncommon (2-15 of total BPPV)

bull Two formsndash Geotropic ndash beating towards undermost ear

ndash Apogeotropic ndash beating away from undermost ear

Sixth Annual Intensive Update in Neurology 0915-162016

25

Geotropic Lateral Canal BPPV

bull Patient is positioned

first to the right lateral

position ndash nystagmus

beats right

bull Patient is then

positioned to the left

lateral position and

nystagmus reverses

and beats left

Sixth Annual Intensive Update in Neurology 0915-162016

26

Left Geotropic Lateral Semicircular Canal BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

27

Repositioning Maneuvers for Geotropic Lateral Semicircular Canal (LSC) BPPV

bull Roll maneuver (Lempert Baloh)

ndash Patient rolls in 90 degree increments towards the good side

completely rolling over R LSC-BPPV repositioning shown

Sixth Annual Intensive Update in Neurology 0915-162016

28

Repositioning Maneuvers for Geotropic LSC BPPV

bull Gufoni maneuver

ndash Patient lies quickly onto good side and turns face-down to

floor for two minutes

Sixth Annual Intensive Update in Neurology 0915-162016

29

Left Apogeotropic LSC BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

30

Nystagmus observed During Repositioning

bull Nystagmus should remain in the same torsional

direction as seen on DHT throughout the treatment of

posterior BPPV

bull Reversal of nystagmus direction suggests the particle

has fallen back into the canal and predicts failure

bull In Lateral BPPV nystagmus should beat towards the

good ear

Sixth Annual Intensive Update in Neurology 0915-162016

31

Posterior to Lateral canal conversion

Sixth Annual Intensive Update in Neurology 0915-162016

32

R Posterior to Lateral Canal conversion - geotropic

Sixth Annual Intensive Update in Neurology 0915-162016

33

BPPV Recurrence

bull Recurrence is common (15yr)

bull Otoconial adherence or mineralization demineralization

abnormalities may contribute to recurrence

bull Home canalith repositioning is effective (Radke 2004)

Sixth Annual Intensive Update in Neurology 0915-162016

34

Question 1

bull The most likely semicircular canal to be affected in

BPPV is

ndash 1) superior

ndash 2) lateral

ndash 3) posterior

ndash 4) combined

Sixth Annual Intensive Update in Neurology 0915-162016

35

Question 1

bull The most likely semicircular canal to be affected in

BPPV is

ndash 1) superior

ndash 2) lateral

ndash 3) posterior

ndash 4) combined

Answer 3 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

36

Acute Vestibular Syndrome

bull Rapid unilateral injury to either peripheral or central

vestibular structures produces prolonged vertigo

(days to weeks)

bull Severe vertigo nausea and vomiting spontaneous

nystagmus and postural instability

Sixth Annual Intensive Update in Neurology 0915-162016

37

Acute Vestibular Syndrome

bull 25 of patients with risk factors who present with isolated severe vertigo nystagmus and postural instability in the ER have an acute infarction of the inferior cerebellum (AICA PICA) Central imaging is suggested (Baloh 1998 NEJM)

ndash HTN diabetes smoking age gt65 Afib valvular heart disease occlusive vascular disease

Sixth Annual Intensive Update in Neurology 0915-162016

38

HINTS test

bull Head Impulse

bull Nystagmus

bull Test of Skew

ndash More sensitive than MRI in the diagnosis of acute stroke in

patients with acute vestibular syndrome with at least one risk

factor (Kattah J et al Stroke 2009)

Sixth Annual Intensive Update in Neurology 0915-162016

39

Head Impulse Test

bull No special equipment needed

bull Examiner stands in front of seated patient and

randomly moves head left and right Patient is asked to

focus on examinerrsquos nose

bull Rapid low amplitude thrust from lateral to straight

ahead causes a compensatory saccade when

performed towards the weak side

bull This finding is a permanent feature of unilateral

vestibular loss

Sixth Annual Intensive Update in Neurology 0915-162016

40

Head Impulse Test

Sixth Annual Intensive Update in Neurology 0915-162016

41

Head CT ndash Academy of Emergency Medicine 2013

bull The clinical value of head CT in isolated

dizzinessvertigo without any associated neurological

symptoms is very low

bull Less than 1 of head CTs ordered for dizziness and

vertigo have significant abnormalities and those

patients had severe headache and neurological deficits

in addition to dizziness

bull Forgoing unnecessary emergency head CTs could

save 360 million dollars annually

Sixth Annual Intensive Update in Neurology 0915-162016

42

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Sixth Annual Intensive Update in Neurology 0915-162016

43

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Answer 2 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

44

Acute Vestibular Syndrome

bull Usually peripheral and can be associated with

hearing loss (labyrinthitis)

bull Timely diagnosis improves recovery (ASAP

prednisone 1mgkgday for ten days and taper 10

mgday ndash Strupp M 2004 NEJM)

bull Avoid vestibular suppressants after 3 days and begin

vestibular rehabilitation to hasten compensation

Sixth Annual Intensive Update in Neurology 0915-162016

45

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

46

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Answer 5 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

47

Menierersquos syndrome

bull Fluctuating low frequency hearing loss

bull Tinnitus andor aural fullness

bull Vertigo lasting hours

Sixth Annual Intensive Update in Neurology 0915-162016

48

Normal

Sixth Annual Intensive Update in Neurology 0915-162016

49

Hydrops

Sixth Annual Intensive Update in Neurology 0915-162016

50

Menierersquos syndrome

ndash Diagnosis- Exclusion (RO acoustic)

ndash 23 of Menierersquos patients will improve spontaneously

ndash Treatment-1500 mgday low sodium triamterene375-

hydrochlorothiazide 25 vestibular suppressants (lorazepam

1 mg tablet sublingual Q 8 prn attacks) off label use

Sixth Annual Intensive Update in Neurology 0915-162016

51

Menierersquos syndrome ndash intratympanic steroids

ndash A newer treatment option for those failing medical management

ndash 90 response rate (Boleus-Aguirre MS Otology Neurotology

2008)

ndash Outcomes data confirm excellent clinical response in 3941

Menierersquos patients treated with intratympanic steroids in 2008

Sixth Annual Intensive Update in Neurology 0915-162016

52

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

53

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Answer 5 See references at end

Sixth Annual Intensive Update in Neurology 0915-162016

54

Superior Semicircular Canal Dehiscence (SSCD)

bull Sound andor pressure induced oscillopsia

bull CT reformatted in the plane of the superior canals

shows dehiscence of overlying bone

bull Low frequency ldquoconductive hyperacusisrdquo with elevated

bone thresholds normal reflexes and a conductive loss

Sixth Annual Intensive Update in Neurology 0915-162016

55

SSCD

bull Positive middle ear pressure or loud sound stimulates ampullofugal endolymph flow -canal activation

bull Eye movements are tonic upwards with ipsilateral intorsion

Sixth Annual Intensive Update in Neurology 0915-162016

56

SSCD

bull Valsalva against a closed glottis or jugular compression causes increased intracranial pressure and ampullopetal endolymph flow -canal inhibition

bull Eye movements are tonic downwards with ipsilateral extorsion

Sixth Annual Intensive Update in Neurology 0915-162016

57

Reconstructed left superior semicircular canal

Sixth Annual Intensive Update in Neurology 0915-162016

58

Sixth Annual Intensive Update in Neurology 0915-162016

59

SCHEMATIC DRAWING OF AN OTOLITHIC MACULA

Sixth Annual Intensive Update in Neurology 0915-162016

60

MACULAE OF THE UTRICLESACCULE

Sixth Annual Intensive Update in Neurology 0915-162016

61

HAIR CELLS

Sixth Annual Intensive Update in Neurology 0915-162016

62

SCANNING ELECTRON MICROGRAPH OF OTOCONIA

Sixth Annual Intensive Update in Neurology 0915-162016

63

Ocular VEMP

bull Response to loud clicks (80-110 dB) or forehead tap (Halmagyi and Curthoys 2003)

bull Contralateral oculomotor nucleus (CN III)

bull Inferior oblique muscle contraction (8 msec) detected by 5sec event triggered averaging

bull Noninverting electrode inferior to eye

bull Inverting below non-inverting electrode

bull Ground to forehead

bull Normal subjects have very low response

Sixth Annual Intensive Update in Neurology 0915-162016

64

Clinical applications

bull The o-VEMP is a sensitive test of otolithutricular

function

bull Complements vestibular test procedures that assess

semicircular canals

bull Abnormally robust responses are associated with third

window abnormalities such as semicircular canal

dehiscence

bull Serves as an excellent screening test for semicircular

canal dehiscence

Sixth Annual Intensive Update in Neurology 0915-162016

65

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Sixth Annual Intensive Update in Neurology 0915-162016

66

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Answer 1 References at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

67

Enlarged vestibular aqueduct

bull Axial temporal bone CT showing right temporal bone with enlarged vestibular aqueduct (arrow)

bull Vestibular symptoms accompany progressive sensorineural hearing loss in 4-50 of patients in selected series

Sixth Annual Intensive Update in Neurology 0915-162016

68

Migraine

bull Family or personal history of migraine

bull 25 of migraine patients experience spontaneous vertigo (Baloh 1997)

bull Neuhauser criteria(2001) have been used to construct structured diagnostic interviews (Furman 2003)

bull Not always associated with headache

bull Motion sensitivity

bull Medication responsive

Sixth Annual Intensive Update in Neurology 0915-162016

69

ICHD-III beta Criteria for Vestibular Migraine

bull A At least five attacks fulfilling criteria C and D

bull B A current or past history of 11 migraine without aura or 12 migraine with aura

bull C Vestibular symptoms of moderate or severe intensity lasting between 5 minutes and 72 hours

bull D At least 50 associated with one of the following migrainous features

ndash 1 Headaches

ndash 2 Photophobia and phonophobia

ndash 3 Visual Aura

bull E Not better accounted for by another vestibular disorder

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 17: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

17

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

18

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

19

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

20

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

21

Canalith Repositioning

bull R posterior

BPPV

CPT 95992

Sixth Annual Intensive Update in Neurology 0915-162016

22

Posterior semicircular canalith repositioning

Sixth Annual Intensive Update in Neurology 0915-162016

23

Supine Positional Tests

Sixth Annual Intensive Update in Neurology 0915-162016

24

Lateral SCC-BPPV

bull Short latency horizontal nystagmus provoked by supine bilateral head turns with prolonged duration and poor fatigability

bull Uncommon (2-15 of total BPPV)

bull Two formsndash Geotropic ndash beating towards undermost ear

ndash Apogeotropic ndash beating away from undermost ear

Sixth Annual Intensive Update in Neurology 0915-162016

25

Geotropic Lateral Canal BPPV

bull Patient is positioned

first to the right lateral

position ndash nystagmus

beats right

bull Patient is then

positioned to the left

lateral position and

nystagmus reverses

and beats left

Sixth Annual Intensive Update in Neurology 0915-162016

26

Left Geotropic Lateral Semicircular Canal BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

27

Repositioning Maneuvers for Geotropic Lateral Semicircular Canal (LSC) BPPV

bull Roll maneuver (Lempert Baloh)

ndash Patient rolls in 90 degree increments towards the good side

completely rolling over R LSC-BPPV repositioning shown

Sixth Annual Intensive Update in Neurology 0915-162016

28

Repositioning Maneuvers for Geotropic LSC BPPV

bull Gufoni maneuver

ndash Patient lies quickly onto good side and turns face-down to

floor for two minutes

Sixth Annual Intensive Update in Neurology 0915-162016

29

Left Apogeotropic LSC BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

30

Nystagmus observed During Repositioning

bull Nystagmus should remain in the same torsional

direction as seen on DHT throughout the treatment of

posterior BPPV

bull Reversal of nystagmus direction suggests the particle

has fallen back into the canal and predicts failure

bull In Lateral BPPV nystagmus should beat towards the

good ear

Sixth Annual Intensive Update in Neurology 0915-162016

31

Posterior to Lateral canal conversion

Sixth Annual Intensive Update in Neurology 0915-162016

32

R Posterior to Lateral Canal conversion - geotropic

Sixth Annual Intensive Update in Neurology 0915-162016

33

BPPV Recurrence

bull Recurrence is common (15yr)

bull Otoconial adherence or mineralization demineralization

abnormalities may contribute to recurrence

bull Home canalith repositioning is effective (Radke 2004)

Sixth Annual Intensive Update in Neurology 0915-162016

34

Question 1

bull The most likely semicircular canal to be affected in

BPPV is

ndash 1) superior

ndash 2) lateral

ndash 3) posterior

ndash 4) combined

Sixth Annual Intensive Update in Neurology 0915-162016

35

Question 1

bull The most likely semicircular canal to be affected in

BPPV is

ndash 1) superior

ndash 2) lateral

ndash 3) posterior

ndash 4) combined

Answer 3 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

36

Acute Vestibular Syndrome

bull Rapid unilateral injury to either peripheral or central

vestibular structures produces prolonged vertigo

(days to weeks)

bull Severe vertigo nausea and vomiting spontaneous

nystagmus and postural instability

Sixth Annual Intensive Update in Neurology 0915-162016

37

Acute Vestibular Syndrome

bull 25 of patients with risk factors who present with isolated severe vertigo nystagmus and postural instability in the ER have an acute infarction of the inferior cerebellum (AICA PICA) Central imaging is suggested (Baloh 1998 NEJM)

ndash HTN diabetes smoking age gt65 Afib valvular heart disease occlusive vascular disease

Sixth Annual Intensive Update in Neurology 0915-162016

38

HINTS test

bull Head Impulse

bull Nystagmus

bull Test of Skew

ndash More sensitive than MRI in the diagnosis of acute stroke in

patients with acute vestibular syndrome with at least one risk

factor (Kattah J et al Stroke 2009)

Sixth Annual Intensive Update in Neurology 0915-162016

39

Head Impulse Test

bull No special equipment needed

bull Examiner stands in front of seated patient and

randomly moves head left and right Patient is asked to

focus on examinerrsquos nose

bull Rapid low amplitude thrust from lateral to straight

ahead causes a compensatory saccade when

performed towards the weak side

bull This finding is a permanent feature of unilateral

vestibular loss

Sixth Annual Intensive Update in Neurology 0915-162016

40

Head Impulse Test

Sixth Annual Intensive Update in Neurology 0915-162016

41

Head CT ndash Academy of Emergency Medicine 2013

bull The clinical value of head CT in isolated

dizzinessvertigo without any associated neurological

symptoms is very low

bull Less than 1 of head CTs ordered for dizziness and

vertigo have significant abnormalities and those

patients had severe headache and neurological deficits

in addition to dizziness

bull Forgoing unnecessary emergency head CTs could

save 360 million dollars annually

Sixth Annual Intensive Update in Neurology 0915-162016

42

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Sixth Annual Intensive Update in Neurology 0915-162016

43

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Answer 2 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

44

Acute Vestibular Syndrome

bull Usually peripheral and can be associated with

hearing loss (labyrinthitis)

bull Timely diagnosis improves recovery (ASAP

prednisone 1mgkgday for ten days and taper 10

mgday ndash Strupp M 2004 NEJM)

bull Avoid vestibular suppressants after 3 days and begin

vestibular rehabilitation to hasten compensation

Sixth Annual Intensive Update in Neurology 0915-162016

45

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

46

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Answer 5 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

47

Menierersquos syndrome

bull Fluctuating low frequency hearing loss

bull Tinnitus andor aural fullness

bull Vertigo lasting hours

Sixth Annual Intensive Update in Neurology 0915-162016

48

Normal

Sixth Annual Intensive Update in Neurology 0915-162016

49

Hydrops

Sixth Annual Intensive Update in Neurology 0915-162016

50

Menierersquos syndrome

ndash Diagnosis- Exclusion (RO acoustic)

ndash 23 of Menierersquos patients will improve spontaneously

ndash Treatment-1500 mgday low sodium triamterene375-

hydrochlorothiazide 25 vestibular suppressants (lorazepam

1 mg tablet sublingual Q 8 prn attacks) off label use

Sixth Annual Intensive Update in Neurology 0915-162016

51

Menierersquos syndrome ndash intratympanic steroids

ndash A newer treatment option for those failing medical management

ndash 90 response rate (Boleus-Aguirre MS Otology Neurotology

2008)

ndash Outcomes data confirm excellent clinical response in 3941

Menierersquos patients treated with intratympanic steroids in 2008

Sixth Annual Intensive Update in Neurology 0915-162016

52

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

53

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Answer 5 See references at end

Sixth Annual Intensive Update in Neurology 0915-162016

54

Superior Semicircular Canal Dehiscence (SSCD)

bull Sound andor pressure induced oscillopsia

bull CT reformatted in the plane of the superior canals

shows dehiscence of overlying bone

bull Low frequency ldquoconductive hyperacusisrdquo with elevated

bone thresholds normal reflexes and a conductive loss

Sixth Annual Intensive Update in Neurology 0915-162016

55

SSCD

bull Positive middle ear pressure or loud sound stimulates ampullofugal endolymph flow -canal activation

bull Eye movements are tonic upwards with ipsilateral intorsion

Sixth Annual Intensive Update in Neurology 0915-162016

56

SSCD

bull Valsalva against a closed glottis or jugular compression causes increased intracranial pressure and ampullopetal endolymph flow -canal inhibition

bull Eye movements are tonic downwards with ipsilateral extorsion

Sixth Annual Intensive Update in Neurology 0915-162016

57

Reconstructed left superior semicircular canal

Sixth Annual Intensive Update in Neurology 0915-162016

58

Sixth Annual Intensive Update in Neurology 0915-162016

59

SCHEMATIC DRAWING OF AN OTOLITHIC MACULA

Sixth Annual Intensive Update in Neurology 0915-162016

60

MACULAE OF THE UTRICLESACCULE

Sixth Annual Intensive Update in Neurology 0915-162016

61

HAIR CELLS

Sixth Annual Intensive Update in Neurology 0915-162016

62

SCANNING ELECTRON MICROGRAPH OF OTOCONIA

Sixth Annual Intensive Update in Neurology 0915-162016

63

Ocular VEMP

bull Response to loud clicks (80-110 dB) or forehead tap (Halmagyi and Curthoys 2003)

bull Contralateral oculomotor nucleus (CN III)

bull Inferior oblique muscle contraction (8 msec) detected by 5sec event triggered averaging

bull Noninverting electrode inferior to eye

bull Inverting below non-inverting electrode

bull Ground to forehead

bull Normal subjects have very low response

Sixth Annual Intensive Update in Neurology 0915-162016

64

Clinical applications

bull The o-VEMP is a sensitive test of otolithutricular

function

bull Complements vestibular test procedures that assess

semicircular canals

bull Abnormally robust responses are associated with third

window abnormalities such as semicircular canal

dehiscence

bull Serves as an excellent screening test for semicircular

canal dehiscence

Sixth Annual Intensive Update in Neurology 0915-162016

65

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Sixth Annual Intensive Update in Neurology 0915-162016

66

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Answer 1 References at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

67

Enlarged vestibular aqueduct

bull Axial temporal bone CT showing right temporal bone with enlarged vestibular aqueduct (arrow)

bull Vestibular symptoms accompany progressive sensorineural hearing loss in 4-50 of patients in selected series

Sixth Annual Intensive Update in Neurology 0915-162016

68

Migraine

bull Family or personal history of migraine

bull 25 of migraine patients experience spontaneous vertigo (Baloh 1997)

bull Neuhauser criteria(2001) have been used to construct structured diagnostic interviews (Furman 2003)

bull Not always associated with headache

bull Motion sensitivity

bull Medication responsive

Sixth Annual Intensive Update in Neurology 0915-162016

69

ICHD-III beta Criteria for Vestibular Migraine

bull A At least five attacks fulfilling criteria C and D

bull B A current or past history of 11 migraine without aura or 12 migraine with aura

bull C Vestibular symptoms of moderate or severe intensity lasting between 5 minutes and 72 hours

bull D At least 50 associated with one of the following migrainous features

ndash 1 Headaches

ndash 2 Photophobia and phonophobia

ndash 3 Visual Aura

bull E Not better accounted for by another vestibular disorder

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 18: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

18

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

19

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

20

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

21

Canalith Repositioning

bull R posterior

BPPV

CPT 95992

Sixth Annual Intensive Update in Neurology 0915-162016

22

Posterior semicircular canalith repositioning

Sixth Annual Intensive Update in Neurology 0915-162016

23

Supine Positional Tests

Sixth Annual Intensive Update in Neurology 0915-162016

24

Lateral SCC-BPPV

bull Short latency horizontal nystagmus provoked by supine bilateral head turns with prolonged duration and poor fatigability

bull Uncommon (2-15 of total BPPV)

bull Two formsndash Geotropic ndash beating towards undermost ear

ndash Apogeotropic ndash beating away from undermost ear

Sixth Annual Intensive Update in Neurology 0915-162016

25

Geotropic Lateral Canal BPPV

bull Patient is positioned

first to the right lateral

position ndash nystagmus

beats right

bull Patient is then

positioned to the left

lateral position and

nystagmus reverses

and beats left

Sixth Annual Intensive Update in Neurology 0915-162016

26

Left Geotropic Lateral Semicircular Canal BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

27

Repositioning Maneuvers for Geotropic Lateral Semicircular Canal (LSC) BPPV

bull Roll maneuver (Lempert Baloh)

ndash Patient rolls in 90 degree increments towards the good side

completely rolling over R LSC-BPPV repositioning shown

Sixth Annual Intensive Update in Neurology 0915-162016

28

Repositioning Maneuvers for Geotropic LSC BPPV

bull Gufoni maneuver

ndash Patient lies quickly onto good side and turns face-down to

floor for two minutes

Sixth Annual Intensive Update in Neurology 0915-162016

29

Left Apogeotropic LSC BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

30

Nystagmus observed During Repositioning

bull Nystagmus should remain in the same torsional

direction as seen on DHT throughout the treatment of

posterior BPPV

bull Reversal of nystagmus direction suggests the particle

has fallen back into the canal and predicts failure

bull In Lateral BPPV nystagmus should beat towards the

good ear

Sixth Annual Intensive Update in Neurology 0915-162016

31

Posterior to Lateral canal conversion

Sixth Annual Intensive Update in Neurology 0915-162016

32

R Posterior to Lateral Canal conversion - geotropic

Sixth Annual Intensive Update in Neurology 0915-162016

33

BPPV Recurrence

bull Recurrence is common (15yr)

bull Otoconial adherence or mineralization demineralization

abnormalities may contribute to recurrence

bull Home canalith repositioning is effective (Radke 2004)

Sixth Annual Intensive Update in Neurology 0915-162016

34

Question 1

bull The most likely semicircular canal to be affected in

BPPV is

ndash 1) superior

ndash 2) lateral

ndash 3) posterior

ndash 4) combined

Sixth Annual Intensive Update in Neurology 0915-162016

35

Question 1

bull The most likely semicircular canal to be affected in

BPPV is

ndash 1) superior

ndash 2) lateral

ndash 3) posterior

ndash 4) combined

Answer 3 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

36

Acute Vestibular Syndrome

bull Rapid unilateral injury to either peripheral or central

vestibular structures produces prolonged vertigo

(days to weeks)

bull Severe vertigo nausea and vomiting spontaneous

nystagmus and postural instability

Sixth Annual Intensive Update in Neurology 0915-162016

37

Acute Vestibular Syndrome

bull 25 of patients with risk factors who present with isolated severe vertigo nystagmus and postural instability in the ER have an acute infarction of the inferior cerebellum (AICA PICA) Central imaging is suggested (Baloh 1998 NEJM)

ndash HTN diabetes smoking age gt65 Afib valvular heart disease occlusive vascular disease

Sixth Annual Intensive Update in Neurology 0915-162016

38

HINTS test

bull Head Impulse

bull Nystagmus

bull Test of Skew

ndash More sensitive than MRI in the diagnosis of acute stroke in

patients with acute vestibular syndrome with at least one risk

factor (Kattah J et al Stroke 2009)

Sixth Annual Intensive Update in Neurology 0915-162016

39

Head Impulse Test

bull No special equipment needed

bull Examiner stands in front of seated patient and

randomly moves head left and right Patient is asked to

focus on examinerrsquos nose

bull Rapid low amplitude thrust from lateral to straight

ahead causes a compensatory saccade when

performed towards the weak side

bull This finding is a permanent feature of unilateral

vestibular loss

Sixth Annual Intensive Update in Neurology 0915-162016

40

Head Impulse Test

Sixth Annual Intensive Update in Neurology 0915-162016

41

Head CT ndash Academy of Emergency Medicine 2013

bull The clinical value of head CT in isolated

dizzinessvertigo without any associated neurological

symptoms is very low

bull Less than 1 of head CTs ordered for dizziness and

vertigo have significant abnormalities and those

patients had severe headache and neurological deficits

in addition to dizziness

bull Forgoing unnecessary emergency head CTs could

save 360 million dollars annually

Sixth Annual Intensive Update in Neurology 0915-162016

42

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Sixth Annual Intensive Update in Neurology 0915-162016

43

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Answer 2 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

44

Acute Vestibular Syndrome

bull Usually peripheral and can be associated with

hearing loss (labyrinthitis)

bull Timely diagnosis improves recovery (ASAP

prednisone 1mgkgday for ten days and taper 10

mgday ndash Strupp M 2004 NEJM)

bull Avoid vestibular suppressants after 3 days and begin

vestibular rehabilitation to hasten compensation

Sixth Annual Intensive Update in Neurology 0915-162016

45

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

46

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Answer 5 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

47

Menierersquos syndrome

bull Fluctuating low frequency hearing loss

bull Tinnitus andor aural fullness

bull Vertigo lasting hours

Sixth Annual Intensive Update in Neurology 0915-162016

48

Normal

Sixth Annual Intensive Update in Neurology 0915-162016

49

Hydrops

Sixth Annual Intensive Update in Neurology 0915-162016

50

Menierersquos syndrome

ndash Diagnosis- Exclusion (RO acoustic)

ndash 23 of Menierersquos patients will improve spontaneously

ndash Treatment-1500 mgday low sodium triamterene375-

hydrochlorothiazide 25 vestibular suppressants (lorazepam

1 mg tablet sublingual Q 8 prn attacks) off label use

Sixth Annual Intensive Update in Neurology 0915-162016

51

Menierersquos syndrome ndash intratympanic steroids

ndash A newer treatment option for those failing medical management

ndash 90 response rate (Boleus-Aguirre MS Otology Neurotology

2008)

ndash Outcomes data confirm excellent clinical response in 3941

Menierersquos patients treated with intratympanic steroids in 2008

Sixth Annual Intensive Update in Neurology 0915-162016

52

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

53

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Answer 5 See references at end

Sixth Annual Intensive Update in Neurology 0915-162016

54

Superior Semicircular Canal Dehiscence (SSCD)

bull Sound andor pressure induced oscillopsia

bull CT reformatted in the plane of the superior canals

shows dehiscence of overlying bone

bull Low frequency ldquoconductive hyperacusisrdquo with elevated

bone thresholds normal reflexes and a conductive loss

Sixth Annual Intensive Update in Neurology 0915-162016

55

SSCD

bull Positive middle ear pressure or loud sound stimulates ampullofugal endolymph flow -canal activation

bull Eye movements are tonic upwards with ipsilateral intorsion

Sixth Annual Intensive Update in Neurology 0915-162016

56

SSCD

bull Valsalva against a closed glottis or jugular compression causes increased intracranial pressure and ampullopetal endolymph flow -canal inhibition

bull Eye movements are tonic downwards with ipsilateral extorsion

Sixth Annual Intensive Update in Neurology 0915-162016

57

Reconstructed left superior semicircular canal

Sixth Annual Intensive Update in Neurology 0915-162016

58

Sixth Annual Intensive Update in Neurology 0915-162016

59

SCHEMATIC DRAWING OF AN OTOLITHIC MACULA

Sixth Annual Intensive Update in Neurology 0915-162016

60

MACULAE OF THE UTRICLESACCULE

Sixth Annual Intensive Update in Neurology 0915-162016

61

HAIR CELLS

Sixth Annual Intensive Update in Neurology 0915-162016

62

SCANNING ELECTRON MICROGRAPH OF OTOCONIA

Sixth Annual Intensive Update in Neurology 0915-162016

63

Ocular VEMP

bull Response to loud clicks (80-110 dB) or forehead tap (Halmagyi and Curthoys 2003)

bull Contralateral oculomotor nucleus (CN III)

bull Inferior oblique muscle contraction (8 msec) detected by 5sec event triggered averaging

bull Noninverting electrode inferior to eye

bull Inverting below non-inverting electrode

bull Ground to forehead

bull Normal subjects have very low response

Sixth Annual Intensive Update in Neurology 0915-162016

64

Clinical applications

bull The o-VEMP is a sensitive test of otolithutricular

function

bull Complements vestibular test procedures that assess

semicircular canals

bull Abnormally robust responses are associated with third

window abnormalities such as semicircular canal

dehiscence

bull Serves as an excellent screening test for semicircular

canal dehiscence

Sixth Annual Intensive Update in Neurology 0915-162016

65

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Sixth Annual Intensive Update in Neurology 0915-162016

66

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Answer 1 References at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

67

Enlarged vestibular aqueduct

bull Axial temporal bone CT showing right temporal bone with enlarged vestibular aqueduct (arrow)

bull Vestibular symptoms accompany progressive sensorineural hearing loss in 4-50 of patients in selected series

Sixth Annual Intensive Update in Neurology 0915-162016

68

Migraine

bull Family or personal history of migraine

bull 25 of migraine patients experience spontaneous vertigo (Baloh 1997)

bull Neuhauser criteria(2001) have been used to construct structured diagnostic interviews (Furman 2003)

bull Not always associated with headache

bull Motion sensitivity

bull Medication responsive

Sixth Annual Intensive Update in Neurology 0915-162016

69

ICHD-III beta Criteria for Vestibular Migraine

bull A At least five attacks fulfilling criteria C and D

bull B A current or past history of 11 migraine without aura or 12 migraine with aura

bull C Vestibular symptoms of moderate or severe intensity lasting between 5 minutes and 72 hours

bull D At least 50 associated with one of the following migrainous features

ndash 1 Headaches

ndash 2 Photophobia and phonophobia

ndash 3 Visual Aura

bull E Not better accounted for by another vestibular disorder

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 19: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

19

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

20

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

21

Canalith Repositioning

bull R posterior

BPPV

CPT 95992

Sixth Annual Intensive Update in Neurology 0915-162016

22

Posterior semicircular canalith repositioning

Sixth Annual Intensive Update in Neurology 0915-162016

23

Supine Positional Tests

Sixth Annual Intensive Update in Neurology 0915-162016

24

Lateral SCC-BPPV

bull Short latency horizontal nystagmus provoked by supine bilateral head turns with prolonged duration and poor fatigability

bull Uncommon (2-15 of total BPPV)

bull Two formsndash Geotropic ndash beating towards undermost ear

ndash Apogeotropic ndash beating away from undermost ear

Sixth Annual Intensive Update in Neurology 0915-162016

25

Geotropic Lateral Canal BPPV

bull Patient is positioned

first to the right lateral

position ndash nystagmus

beats right

bull Patient is then

positioned to the left

lateral position and

nystagmus reverses

and beats left

Sixth Annual Intensive Update in Neurology 0915-162016

26

Left Geotropic Lateral Semicircular Canal BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

27

Repositioning Maneuvers for Geotropic Lateral Semicircular Canal (LSC) BPPV

bull Roll maneuver (Lempert Baloh)

ndash Patient rolls in 90 degree increments towards the good side

completely rolling over R LSC-BPPV repositioning shown

Sixth Annual Intensive Update in Neurology 0915-162016

28

Repositioning Maneuvers for Geotropic LSC BPPV

bull Gufoni maneuver

ndash Patient lies quickly onto good side and turns face-down to

floor for two minutes

Sixth Annual Intensive Update in Neurology 0915-162016

29

Left Apogeotropic LSC BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

30

Nystagmus observed During Repositioning

bull Nystagmus should remain in the same torsional

direction as seen on DHT throughout the treatment of

posterior BPPV

bull Reversal of nystagmus direction suggests the particle

has fallen back into the canal and predicts failure

bull In Lateral BPPV nystagmus should beat towards the

good ear

Sixth Annual Intensive Update in Neurology 0915-162016

31

Posterior to Lateral canal conversion

Sixth Annual Intensive Update in Neurology 0915-162016

32

R Posterior to Lateral Canal conversion - geotropic

Sixth Annual Intensive Update in Neurology 0915-162016

33

BPPV Recurrence

bull Recurrence is common (15yr)

bull Otoconial adherence or mineralization demineralization

abnormalities may contribute to recurrence

bull Home canalith repositioning is effective (Radke 2004)

Sixth Annual Intensive Update in Neurology 0915-162016

34

Question 1

bull The most likely semicircular canal to be affected in

BPPV is

ndash 1) superior

ndash 2) lateral

ndash 3) posterior

ndash 4) combined

Sixth Annual Intensive Update in Neurology 0915-162016

35

Question 1

bull The most likely semicircular canal to be affected in

BPPV is

ndash 1) superior

ndash 2) lateral

ndash 3) posterior

ndash 4) combined

Answer 3 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

36

Acute Vestibular Syndrome

bull Rapid unilateral injury to either peripheral or central

vestibular structures produces prolonged vertigo

(days to weeks)

bull Severe vertigo nausea and vomiting spontaneous

nystagmus and postural instability

Sixth Annual Intensive Update in Neurology 0915-162016

37

Acute Vestibular Syndrome

bull 25 of patients with risk factors who present with isolated severe vertigo nystagmus and postural instability in the ER have an acute infarction of the inferior cerebellum (AICA PICA) Central imaging is suggested (Baloh 1998 NEJM)

ndash HTN diabetes smoking age gt65 Afib valvular heart disease occlusive vascular disease

Sixth Annual Intensive Update in Neurology 0915-162016

38

HINTS test

bull Head Impulse

bull Nystagmus

bull Test of Skew

ndash More sensitive than MRI in the diagnosis of acute stroke in

patients with acute vestibular syndrome with at least one risk

factor (Kattah J et al Stroke 2009)

Sixth Annual Intensive Update in Neurology 0915-162016

39

Head Impulse Test

bull No special equipment needed

bull Examiner stands in front of seated patient and

randomly moves head left and right Patient is asked to

focus on examinerrsquos nose

bull Rapid low amplitude thrust from lateral to straight

ahead causes a compensatory saccade when

performed towards the weak side

bull This finding is a permanent feature of unilateral

vestibular loss

Sixth Annual Intensive Update in Neurology 0915-162016

40

Head Impulse Test

Sixth Annual Intensive Update in Neurology 0915-162016

41

Head CT ndash Academy of Emergency Medicine 2013

bull The clinical value of head CT in isolated

dizzinessvertigo without any associated neurological

symptoms is very low

bull Less than 1 of head CTs ordered for dizziness and

vertigo have significant abnormalities and those

patients had severe headache and neurological deficits

in addition to dizziness

bull Forgoing unnecessary emergency head CTs could

save 360 million dollars annually

Sixth Annual Intensive Update in Neurology 0915-162016

42

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Sixth Annual Intensive Update in Neurology 0915-162016

43

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Answer 2 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

44

Acute Vestibular Syndrome

bull Usually peripheral and can be associated with

hearing loss (labyrinthitis)

bull Timely diagnosis improves recovery (ASAP

prednisone 1mgkgday for ten days and taper 10

mgday ndash Strupp M 2004 NEJM)

bull Avoid vestibular suppressants after 3 days and begin

vestibular rehabilitation to hasten compensation

Sixth Annual Intensive Update in Neurology 0915-162016

45

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

46

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Answer 5 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

47

Menierersquos syndrome

bull Fluctuating low frequency hearing loss

bull Tinnitus andor aural fullness

bull Vertigo lasting hours

Sixth Annual Intensive Update in Neurology 0915-162016

48

Normal

Sixth Annual Intensive Update in Neurology 0915-162016

49

Hydrops

Sixth Annual Intensive Update in Neurology 0915-162016

50

Menierersquos syndrome

ndash Diagnosis- Exclusion (RO acoustic)

ndash 23 of Menierersquos patients will improve spontaneously

ndash Treatment-1500 mgday low sodium triamterene375-

hydrochlorothiazide 25 vestibular suppressants (lorazepam

1 mg tablet sublingual Q 8 prn attacks) off label use

Sixth Annual Intensive Update in Neurology 0915-162016

51

Menierersquos syndrome ndash intratympanic steroids

ndash A newer treatment option for those failing medical management

ndash 90 response rate (Boleus-Aguirre MS Otology Neurotology

2008)

ndash Outcomes data confirm excellent clinical response in 3941

Menierersquos patients treated with intratympanic steroids in 2008

Sixth Annual Intensive Update in Neurology 0915-162016

52

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

53

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Answer 5 See references at end

Sixth Annual Intensive Update in Neurology 0915-162016

54

Superior Semicircular Canal Dehiscence (SSCD)

bull Sound andor pressure induced oscillopsia

bull CT reformatted in the plane of the superior canals

shows dehiscence of overlying bone

bull Low frequency ldquoconductive hyperacusisrdquo with elevated

bone thresholds normal reflexes and a conductive loss

Sixth Annual Intensive Update in Neurology 0915-162016

55

SSCD

bull Positive middle ear pressure or loud sound stimulates ampullofugal endolymph flow -canal activation

bull Eye movements are tonic upwards with ipsilateral intorsion

Sixth Annual Intensive Update in Neurology 0915-162016

56

SSCD

bull Valsalva against a closed glottis or jugular compression causes increased intracranial pressure and ampullopetal endolymph flow -canal inhibition

bull Eye movements are tonic downwards with ipsilateral extorsion

Sixth Annual Intensive Update in Neurology 0915-162016

57

Reconstructed left superior semicircular canal

Sixth Annual Intensive Update in Neurology 0915-162016

58

Sixth Annual Intensive Update in Neurology 0915-162016

59

SCHEMATIC DRAWING OF AN OTOLITHIC MACULA

Sixth Annual Intensive Update in Neurology 0915-162016

60

MACULAE OF THE UTRICLESACCULE

Sixth Annual Intensive Update in Neurology 0915-162016

61

HAIR CELLS

Sixth Annual Intensive Update in Neurology 0915-162016

62

SCANNING ELECTRON MICROGRAPH OF OTOCONIA

Sixth Annual Intensive Update in Neurology 0915-162016

63

Ocular VEMP

bull Response to loud clicks (80-110 dB) or forehead tap (Halmagyi and Curthoys 2003)

bull Contralateral oculomotor nucleus (CN III)

bull Inferior oblique muscle contraction (8 msec) detected by 5sec event triggered averaging

bull Noninverting electrode inferior to eye

bull Inverting below non-inverting electrode

bull Ground to forehead

bull Normal subjects have very low response

Sixth Annual Intensive Update in Neurology 0915-162016

64

Clinical applications

bull The o-VEMP is a sensitive test of otolithutricular

function

bull Complements vestibular test procedures that assess

semicircular canals

bull Abnormally robust responses are associated with third

window abnormalities such as semicircular canal

dehiscence

bull Serves as an excellent screening test for semicircular

canal dehiscence

Sixth Annual Intensive Update in Neurology 0915-162016

65

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Sixth Annual Intensive Update in Neurology 0915-162016

66

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Answer 1 References at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

67

Enlarged vestibular aqueduct

bull Axial temporal bone CT showing right temporal bone with enlarged vestibular aqueduct (arrow)

bull Vestibular symptoms accompany progressive sensorineural hearing loss in 4-50 of patients in selected series

Sixth Annual Intensive Update in Neurology 0915-162016

68

Migraine

bull Family or personal history of migraine

bull 25 of migraine patients experience spontaneous vertigo (Baloh 1997)

bull Neuhauser criteria(2001) have been used to construct structured diagnostic interviews (Furman 2003)

bull Not always associated with headache

bull Motion sensitivity

bull Medication responsive

Sixth Annual Intensive Update in Neurology 0915-162016

69

ICHD-III beta Criteria for Vestibular Migraine

bull A At least five attacks fulfilling criteria C and D

bull B A current or past history of 11 migraine without aura or 12 migraine with aura

bull C Vestibular symptoms of moderate or severe intensity lasting between 5 minutes and 72 hours

bull D At least 50 associated with one of the following migrainous features

ndash 1 Headaches

ndash 2 Photophobia and phonophobia

ndash 3 Visual Aura

bull E Not better accounted for by another vestibular disorder

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 20: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

20

Canalith Repositioning Procedure

Sixth Annual Intensive Update in Neurology 0915-162016

21

Canalith Repositioning

bull R posterior

BPPV

CPT 95992

Sixth Annual Intensive Update in Neurology 0915-162016

22

Posterior semicircular canalith repositioning

Sixth Annual Intensive Update in Neurology 0915-162016

23

Supine Positional Tests

Sixth Annual Intensive Update in Neurology 0915-162016

24

Lateral SCC-BPPV

bull Short latency horizontal nystagmus provoked by supine bilateral head turns with prolonged duration and poor fatigability

bull Uncommon (2-15 of total BPPV)

bull Two formsndash Geotropic ndash beating towards undermost ear

ndash Apogeotropic ndash beating away from undermost ear

Sixth Annual Intensive Update in Neurology 0915-162016

25

Geotropic Lateral Canal BPPV

bull Patient is positioned

first to the right lateral

position ndash nystagmus

beats right

bull Patient is then

positioned to the left

lateral position and

nystagmus reverses

and beats left

Sixth Annual Intensive Update in Neurology 0915-162016

26

Left Geotropic Lateral Semicircular Canal BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

27

Repositioning Maneuvers for Geotropic Lateral Semicircular Canal (LSC) BPPV

bull Roll maneuver (Lempert Baloh)

ndash Patient rolls in 90 degree increments towards the good side

completely rolling over R LSC-BPPV repositioning shown

Sixth Annual Intensive Update in Neurology 0915-162016

28

Repositioning Maneuvers for Geotropic LSC BPPV

bull Gufoni maneuver

ndash Patient lies quickly onto good side and turns face-down to

floor for two minutes

Sixth Annual Intensive Update in Neurology 0915-162016

29

Left Apogeotropic LSC BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

30

Nystagmus observed During Repositioning

bull Nystagmus should remain in the same torsional

direction as seen on DHT throughout the treatment of

posterior BPPV

bull Reversal of nystagmus direction suggests the particle

has fallen back into the canal and predicts failure

bull In Lateral BPPV nystagmus should beat towards the

good ear

Sixth Annual Intensive Update in Neurology 0915-162016

31

Posterior to Lateral canal conversion

Sixth Annual Intensive Update in Neurology 0915-162016

32

R Posterior to Lateral Canal conversion - geotropic

Sixth Annual Intensive Update in Neurology 0915-162016

33

BPPV Recurrence

bull Recurrence is common (15yr)

bull Otoconial adherence or mineralization demineralization

abnormalities may contribute to recurrence

bull Home canalith repositioning is effective (Radke 2004)

Sixth Annual Intensive Update in Neurology 0915-162016

34

Question 1

bull The most likely semicircular canal to be affected in

BPPV is

ndash 1) superior

ndash 2) lateral

ndash 3) posterior

ndash 4) combined

Sixth Annual Intensive Update in Neurology 0915-162016

35

Question 1

bull The most likely semicircular canal to be affected in

BPPV is

ndash 1) superior

ndash 2) lateral

ndash 3) posterior

ndash 4) combined

Answer 3 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

36

Acute Vestibular Syndrome

bull Rapid unilateral injury to either peripheral or central

vestibular structures produces prolonged vertigo

(days to weeks)

bull Severe vertigo nausea and vomiting spontaneous

nystagmus and postural instability

Sixth Annual Intensive Update in Neurology 0915-162016

37

Acute Vestibular Syndrome

bull 25 of patients with risk factors who present with isolated severe vertigo nystagmus and postural instability in the ER have an acute infarction of the inferior cerebellum (AICA PICA) Central imaging is suggested (Baloh 1998 NEJM)

ndash HTN diabetes smoking age gt65 Afib valvular heart disease occlusive vascular disease

Sixth Annual Intensive Update in Neurology 0915-162016

38

HINTS test

bull Head Impulse

bull Nystagmus

bull Test of Skew

ndash More sensitive than MRI in the diagnosis of acute stroke in

patients with acute vestibular syndrome with at least one risk

factor (Kattah J et al Stroke 2009)

Sixth Annual Intensive Update in Neurology 0915-162016

39

Head Impulse Test

bull No special equipment needed

bull Examiner stands in front of seated patient and

randomly moves head left and right Patient is asked to

focus on examinerrsquos nose

bull Rapid low amplitude thrust from lateral to straight

ahead causes a compensatory saccade when

performed towards the weak side

bull This finding is a permanent feature of unilateral

vestibular loss

Sixth Annual Intensive Update in Neurology 0915-162016

40

Head Impulse Test

Sixth Annual Intensive Update in Neurology 0915-162016

41

Head CT ndash Academy of Emergency Medicine 2013

bull The clinical value of head CT in isolated

dizzinessvertigo without any associated neurological

symptoms is very low

bull Less than 1 of head CTs ordered for dizziness and

vertigo have significant abnormalities and those

patients had severe headache and neurological deficits

in addition to dizziness

bull Forgoing unnecessary emergency head CTs could

save 360 million dollars annually

Sixth Annual Intensive Update in Neurology 0915-162016

42

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Sixth Annual Intensive Update in Neurology 0915-162016

43

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Answer 2 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

44

Acute Vestibular Syndrome

bull Usually peripheral and can be associated with

hearing loss (labyrinthitis)

bull Timely diagnosis improves recovery (ASAP

prednisone 1mgkgday for ten days and taper 10

mgday ndash Strupp M 2004 NEJM)

bull Avoid vestibular suppressants after 3 days and begin

vestibular rehabilitation to hasten compensation

Sixth Annual Intensive Update in Neurology 0915-162016

45

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

46

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Answer 5 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

47

Menierersquos syndrome

bull Fluctuating low frequency hearing loss

bull Tinnitus andor aural fullness

bull Vertigo lasting hours

Sixth Annual Intensive Update in Neurology 0915-162016

48

Normal

Sixth Annual Intensive Update in Neurology 0915-162016

49

Hydrops

Sixth Annual Intensive Update in Neurology 0915-162016

50

Menierersquos syndrome

ndash Diagnosis- Exclusion (RO acoustic)

ndash 23 of Menierersquos patients will improve spontaneously

ndash Treatment-1500 mgday low sodium triamterene375-

hydrochlorothiazide 25 vestibular suppressants (lorazepam

1 mg tablet sublingual Q 8 prn attacks) off label use

Sixth Annual Intensive Update in Neurology 0915-162016

51

Menierersquos syndrome ndash intratympanic steroids

ndash A newer treatment option for those failing medical management

ndash 90 response rate (Boleus-Aguirre MS Otology Neurotology

2008)

ndash Outcomes data confirm excellent clinical response in 3941

Menierersquos patients treated with intratympanic steroids in 2008

Sixth Annual Intensive Update in Neurology 0915-162016

52

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

53

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Answer 5 See references at end

Sixth Annual Intensive Update in Neurology 0915-162016

54

Superior Semicircular Canal Dehiscence (SSCD)

bull Sound andor pressure induced oscillopsia

bull CT reformatted in the plane of the superior canals

shows dehiscence of overlying bone

bull Low frequency ldquoconductive hyperacusisrdquo with elevated

bone thresholds normal reflexes and a conductive loss

Sixth Annual Intensive Update in Neurology 0915-162016

55

SSCD

bull Positive middle ear pressure or loud sound stimulates ampullofugal endolymph flow -canal activation

bull Eye movements are tonic upwards with ipsilateral intorsion

Sixth Annual Intensive Update in Neurology 0915-162016

56

SSCD

bull Valsalva against a closed glottis or jugular compression causes increased intracranial pressure and ampullopetal endolymph flow -canal inhibition

bull Eye movements are tonic downwards with ipsilateral extorsion

Sixth Annual Intensive Update in Neurology 0915-162016

57

Reconstructed left superior semicircular canal

Sixth Annual Intensive Update in Neurology 0915-162016

58

Sixth Annual Intensive Update in Neurology 0915-162016

59

SCHEMATIC DRAWING OF AN OTOLITHIC MACULA

Sixth Annual Intensive Update in Neurology 0915-162016

60

MACULAE OF THE UTRICLESACCULE

Sixth Annual Intensive Update in Neurology 0915-162016

61

HAIR CELLS

Sixth Annual Intensive Update in Neurology 0915-162016

62

SCANNING ELECTRON MICROGRAPH OF OTOCONIA

Sixth Annual Intensive Update in Neurology 0915-162016

63

Ocular VEMP

bull Response to loud clicks (80-110 dB) or forehead tap (Halmagyi and Curthoys 2003)

bull Contralateral oculomotor nucleus (CN III)

bull Inferior oblique muscle contraction (8 msec) detected by 5sec event triggered averaging

bull Noninverting electrode inferior to eye

bull Inverting below non-inverting electrode

bull Ground to forehead

bull Normal subjects have very low response

Sixth Annual Intensive Update in Neurology 0915-162016

64

Clinical applications

bull The o-VEMP is a sensitive test of otolithutricular

function

bull Complements vestibular test procedures that assess

semicircular canals

bull Abnormally robust responses are associated with third

window abnormalities such as semicircular canal

dehiscence

bull Serves as an excellent screening test for semicircular

canal dehiscence

Sixth Annual Intensive Update in Neurology 0915-162016

65

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Sixth Annual Intensive Update in Neurology 0915-162016

66

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Answer 1 References at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

67

Enlarged vestibular aqueduct

bull Axial temporal bone CT showing right temporal bone with enlarged vestibular aqueduct (arrow)

bull Vestibular symptoms accompany progressive sensorineural hearing loss in 4-50 of patients in selected series

Sixth Annual Intensive Update in Neurology 0915-162016

68

Migraine

bull Family or personal history of migraine

bull 25 of migraine patients experience spontaneous vertigo (Baloh 1997)

bull Neuhauser criteria(2001) have been used to construct structured diagnostic interviews (Furman 2003)

bull Not always associated with headache

bull Motion sensitivity

bull Medication responsive

Sixth Annual Intensive Update in Neurology 0915-162016

69

ICHD-III beta Criteria for Vestibular Migraine

bull A At least five attacks fulfilling criteria C and D

bull B A current or past history of 11 migraine without aura or 12 migraine with aura

bull C Vestibular symptoms of moderate or severe intensity lasting between 5 minutes and 72 hours

bull D At least 50 associated with one of the following migrainous features

ndash 1 Headaches

ndash 2 Photophobia and phonophobia

ndash 3 Visual Aura

bull E Not better accounted for by another vestibular disorder

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 21: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

21

Canalith Repositioning

bull R posterior

BPPV

CPT 95992

Sixth Annual Intensive Update in Neurology 0915-162016

22

Posterior semicircular canalith repositioning

Sixth Annual Intensive Update in Neurology 0915-162016

23

Supine Positional Tests

Sixth Annual Intensive Update in Neurology 0915-162016

24

Lateral SCC-BPPV

bull Short latency horizontal nystagmus provoked by supine bilateral head turns with prolonged duration and poor fatigability

bull Uncommon (2-15 of total BPPV)

bull Two formsndash Geotropic ndash beating towards undermost ear

ndash Apogeotropic ndash beating away from undermost ear

Sixth Annual Intensive Update in Neurology 0915-162016

25

Geotropic Lateral Canal BPPV

bull Patient is positioned

first to the right lateral

position ndash nystagmus

beats right

bull Patient is then

positioned to the left

lateral position and

nystagmus reverses

and beats left

Sixth Annual Intensive Update in Neurology 0915-162016

26

Left Geotropic Lateral Semicircular Canal BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

27

Repositioning Maneuvers for Geotropic Lateral Semicircular Canal (LSC) BPPV

bull Roll maneuver (Lempert Baloh)

ndash Patient rolls in 90 degree increments towards the good side

completely rolling over R LSC-BPPV repositioning shown

Sixth Annual Intensive Update in Neurology 0915-162016

28

Repositioning Maneuvers for Geotropic LSC BPPV

bull Gufoni maneuver

ndash Patient lies quickly onto good side and turns face-down to

floor for two minutes

Sixth Annual Intensive Update in Neurology 0915-162016

29

Left Apogeotropic LSC BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

30

Nystagmus observed During Repositioning

bull Nystagmus should remain in the same torsional

direction as seen on DHT throughout the treatment of

posterior BPPV

bull Reversal of nystagmus direction suggests the particle

has fallen back into the canal and predicts failure

bull In Lateral BPPV nystagmus should beat towards the

good ear

Sixth Annual Intensive Update in Neurology 0915-162016

31

Posterior to Lateral canal conversion

Sixth Annual Intensive Update in Neurology 0915-162016

32

R Posterior to Lateral Canal conversion - geotropic

Sixth Annual Intensive Update in Neurology 0915-162016

33

BPPV Recurrence

bull Recurrence is common (15yr)

bull Otoconial adherence or mineralization demineralization

abnormalities may contribute to recurrence

bull Home canalith repositioning is effective (Radke 2004)

Sixth Annual Intensive Update in Neurology 0915-162016

34

Question 1

bull The most likely semicircular canal to be affected in

BPPV is

ndash 1) superior

ndash 2) lateral

ndash 3) posterior

ndash 4) combined

Sixth Annual Intensive Update in Neurology 0915-162016

35

Question 1

bull The most likely semicircular canal to be affected in

BPPV is

ndash 1) superior

ndash 2) lateral

ndash 3) posterior

ndash 4) combined

Answer 3 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

36

Acute Vestibular Syndrome

bull Rapid unilateral injury to either peripheral or central

vestibular structures produces prolonged vertigo

(days to weeks)

bull Severe vertigo nausea and vomiting spontaneous

nystagmus and postural instability

Sixth Annual Intensive Update in Neurology 0915-162016

37

Acute Vestibular Syndrome

bull 25 of patients with risk factors who present with isolated severe vertigo nystagmus and postural instability in the ER have an acute infarction of the inferior cerebellum (AICA PICA) Central imaging is suggested (Baloh 1998 NEJM)

ndash HTN diabetes smoking age gt65 Afib valvular heart disease occlusive vascular disease

Sixth Annual Intensive Update in Neurology 0915-162016

38

HINTS test

bull Head Impulse

bull Nystagmus

bull Test of Skew

ndash More sensitive than MRI in the diagnosis of acute stroke in

patients with acute vestibular syndrome with at least one risk

factor (Kattah J et al Stroke 2009)

Sixth Annual Intensive Update in Neurology 0915-162016

39

Head Impulse Test

bull No special equipment needed

bull Examiner stands in front of seated patient and

randomly moves head left and right Patient is asked to

focus on examinerrsquos nose

bull Rapid low amplitude thrust from lateral to straight

ahead causes a compensatory saccade when

performed towards the weak side

bull This finding is a permanent feature of unilateral

vestibular loss

Sixth Annual Intensive Update in Neurology 0915-162016

40

Head Impulse Test

Sixth Annual Intensive Update in Neurology 0915-162016

41

Head CT ndash Academy of Emergency Medicine 2013

bull The clinical value of head CT in isolated

dizzinessvertigo without any associated neurological

symptoms is very low

bull Less than 1 of head CTs ordered for dizziness and

vertigo have significant abnormalities and those

patients had severe headache and neurological deficits

in addition to dizziness

bull Forgoing unnecessary emergency head CTs could

save 360 million dollars annually

Sixth Annual Intensive Update in Neurology 0915-162016

42

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Sixth Annual Intensive Update in Neurology 0915-162016

43

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Answer 2 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

44

Acute Vestibular Syndrome

bull Usually peripheral and can be associated with

hearing loss (labyrinthitis)

bull Timely diagnosis improves recovery (ASAP

prednisone 1mgkgday for ten days and taper 10

mgday ndash Strupp M 2004 NEJM)

bull Avoid vestibular suppressants after 3 days and begin

vestibular rehabilitation to hasten compensation

Sixth Annual Intensive Update in Neurology 0915-162016

45

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

46

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Answer 5 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

47

Menierersquos syndrome

bull Fluctuating low frequency hearing loss

bull Tinnitus andor aural fullness

bull Vertigo lasting hours

Sixth Annual Intensive Update in Neurology 0915-162016

48

Normal

Sixth Annual Intensive Update in Neurology 0915-162016

49

Hydrops

Sixth Annual Intensive Update in Neurology 0915-162016

50

Menierersquos syndrome

ndash Diagnosis- Exclusion (RO acoustic)

ndash 23 of Menierersquos patients will improve spontaneously

ndash Treatment-1500 mgday low sodium triamterene375-

hydrochlorothiazide 25 vestibular suppressants (lorazepam

1 mg tablet sublingual Q 8 prn attacks) off label use

Sixth Annual Intensive Update in Neurology 0915-162016

51

Menierersquos syndrome ndash intratympanic steroids

ndash A newer treatment option for those failing medical management

ndash 90 response rate (Boleus-Aguirre MS Otology Neurotology

2008)

ndash Outcomes data confirm excellent clinical response in 3941

Menierersquos patients treated with intratympanic steroids in 2008

Sixth Annual Intensive Update in Neurology 0915-162016

52

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

53

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Answer 5 See references at end

Sixth Annual Intensive Update in Neurology 0915-162016

54

Superior Semicircular Canal Dehiscence (SSCD)

bull Sound andor pressure induced oscillopsia

bull CT reformatted in the plane of the superior canals

shows dehiscence of overlying bone

bull Low frequency ldquoconductive hyperacusisrdquo with elevated

bone thresholds normal reflexes and a conductive loss

Sixth Annual Intensive Update in Neurology 0915-162016

55

SSCD

bull Positive middle ear pressure or loud sound stimulates ampullofugal endolymph flow -canal activation

bull Eye movements are tonic upwards with ipsilateral intorsion

Sixth Annual Intensive Update in Neurology 0915-162016

56

SSCD

bull Valsalva against a closed glottis or jugular compression causes increased intracranial pressure and ampullopetal endolymph flow -canal inhibition

bull Eye movements are tonic downwards with ipsilateral extorsion

Sixth Annual Intensive Update in Neurology 0915-162016

57

Reconstructed left superior semicircular canal

Sixth Annual Intensive Update in Neurology 0915-162016

58

Sixth Annual Intensive Update in Neurology 0915-162016

59

SCHEMATIC DRAWING OF AN OTOLITHIC MACULA

Sixth Annual Intensive Update in Neurology 0915-162016

60

MACULAE OF THE UTRICLESACCULE

Sixth Annual Intensive Update in Neurology 0915-162016

61

HAIR CELLS

Sixth Annual Intensive Update in Neurology 0915-162016

62

SCANNING ELECTRON MICROGRAPH OF OTOCONIA

Sixth Annual Intensive Update in Neurology 0915-162016

63

Ocular VEMP

bull Response to loud clicks (80-110 dB) or forehead tap (Halmagyi and Curthoys 2003)

bull Contralateral oculomotor nucleus (CN III)

bull Inferior oblique muscle contraction (8 msec) detected by 5sec event triggered averaging

bull Noninverting electrode inferior to eye

bull Inverting below non-inverting electrode

bull Ground to forehead

bull Normal subjects have very low response

Sixth Annual Intensive Update in Neurology 0915-162016

64

Clinical applications

bull The o-VEMP is a sensitive test of otolithutricular

function

bull Complements vestibular test procedures that assess

semicircular canals

bull Abnormally robust responses are associated with third

window abnormalities such as semicircular canal

dehiscence

bull Serves as an excellent screening test for semicircular

canal dehiscence

Sixth Annual Intensive Update in Neurology 0915-162016

65

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Sixth Annual Intensive Update in Neurology 0915-162016

66

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Answer 1 References at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

67

Enlarged vestibular aqueduct

bull Axial temporal bone CT showing right temporal bone with enlarged vestibular aqueduct (arrow)

bull Vestibular symptoms accompany progressive sensorineural hearing loss in 4-50 of patients in selected series

Sixth Annual Intensive Update in Neurology 0915-162016

68

Migraine

bull Family or personal history of migraine

bull 25 of migraine patients experience spontaneous vertigo (Baloh 1997)

bull Neuhauser criteria(2001) have been used to construct structured diagnostic interviews (Furman 2003)

bull Not always associated with headache

bull Motion sensitivity

bull Medication responsive

Sixth Annual Intensive Update in Neurology 0915-162016

69

ICHD-III beta Criteria for Vestibular Migraine

bull A At least five attacks fulfilling criteria C and D

bull B A current or past history of 11 migraine without aura or 12 migraine with aura

bull C Vestibular symptoms of moderate or severe intensity lasting between 5 minutes and 72 hours

bull D At least 50 associated with one of the following migrainous features

ndash 1 Headaches

ndash 2 Photophobia and phonophobia

ndash 3 Visual Aura

bull E Not better accounted for by another vestibular disorder

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 22: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

22

Posterior semicircular canalith repositioning

Sixth Annual Intensive Update in Neurology 0915-162016

23

Supine Positional Tests

Sixth Annual Intensive Update in Neurology 0915-162016

24

Lateral SCC-BPPV

bull Short latency horizontal nystagmus provoked by supine bilateral head turns with prolonged duration and poor fatigability

bull Uncommon (2-15 of total BPPV)

bull Two formsndash Geotropic ndash beating towards undermost ear

ndash Apogeotropic ndash beating away from undermost ear

Sixth Annual Intensive Update in Neurology 0915-162016

25

Geotropic Lateral Canal BPPV

bull Patient is positioned

first to the right lateral

position ndash nystagmus

beats right

bull Patient is then

positioned to the left

lateral position and

nystagmus reverses

and beats left

Sixth Annual Intensive Update in Neurology 0915-162016

26

Left Geotropic Lateral Semicircular Canal BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

27

Repositioning Maneuvers for Geotropic Lateral Semicircular Canal (LSC) BPPV

bull Roll maneuver (Lempert Baloh)

ndash Patient rolls in 90 degree increments towards the good side

completely rolling over R LSC-BPPV repositioning shown

Sixth Annual Intensive Update in Neurology 0915-162016

28

Repositioning Maneuvers for Geotropic LSC BPPV

bull Gufoni maneuver

ndash Patient lies quickly onto good side and turns face-down to

floor for two minutes

Sixth Annual Intensive Update in Neurology 0915-162016

29

Left Apogeotropic LSC BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

30

Nystagmus observed During Repositioning

bull Nystagmus should remain in the same torsional

direction as seen on DHT throughout the treatment of

posterior BPPV

bull Reversal of nystagmus direction suggests the particle

has fallen back into the canal and predicts failure

bull In Lateral BPPV nystagmus should beat towards the

good ear

Sixth Annual Intensive Update in Neurology 0915-162016

31

Posterior to Lateral canal conversion

Sixth Annual Intensive Update in Neurology 0915-162016

32

R Posterior to Lateral Canal conversion - geotropic

Sixth Annual Intensive Update in Neurology 0915-162016

33

BPPV Recurrence

bull Recurrence is common (15yr)

bull Otoconial adherence or mineralization demineralization

abnormalities may contribute to recurrence

bull Home canalith repositioning is effective (Radke 2004)

Sixth Annual Intensive Update in Neurology 0915-162016

34

Question 1

bull The most likely semicircular canal to be affected in

BPPV is

ndash 1) superior

ndash 2) lateral

ndash 3) posterior

ndash 4) combined

Sixth Annual Intensive Update in Neurology 0915-162016

35

Question 1

bull The most likely semicircular canal to be affected in

BPPV is

ndash 1) superior

ndash 2) lateral

ndash 3) posterior

ndash 4) combined

Answer 3 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

36

Acute Vestibular Syndrome

bull Rapid unilateral injury to either peripheral or central

vestibular structures produces prolonged vertigo

(days to weeks)

bull Severe vertigo nausea and vomiting spontaneous

nystagmus and postural instability

Sixth Annual Intensive Update in Neurology 0915-162016

37

Acute Vestibular Syndrome

bull 25 of patients with risk factors who present with isolated severe vertigo nystagmus and postural instability in the ER have an acute infarction of the inferior cerebellum (AICA PICA) Central imaging is suggested (Baloh 1998 NEJM)

ndash HTN diabetes smoking age gt65 Afib valvular heart disease occlusive vascular disease

Sixth Annual Intensive Update in Neurology 0915-162016

38

HINTS test

bull Head Impulse

bull Nystagmus

bull Test of Skew

ndash More sensitive than MRI in the diagnosis of acute stroke in

patients with acute vestibular syndrome with at least one risk

factor (Kattah J et al Stroke 2009)

Sixth Annual Intensive Update in Neurology 0915-162016

39

Head Impulse Test

bull No special equipment needed

bull Examiner stands in front of seated patient and

randomly moves head left and right Patient is asked to

focus on examinerrsquos nose

bull Rapid low amplitude thrust from lateral to straight

ahead causes a compensatory saccade when

performed towards the weak side

bull This finding is a permanent feature of unilateral

vestibular loss

Sixth Annual Intensive Update in Neurology 0915-162016

40

Head Impulse Test

Sixth Annual Intensive Update in Neurology 0915-162016

41

Head CT ndash Academy of Emergency Medicine 2013

bull The clinical value of head CT in isolated

dizzinessvertigo without any associated neurological

symptoms is very low

bull Less than 1 of head CTs ordered for dizziness and

vertigo have significant abnormalities and those

patients had severe headache and neurological deficits

in addition to dizziness

bull Forgoing unnecessary emergency head CTs could

save 360 million dollars annually

Sixth Annual Intensive Update in Neurology 0915-162016

42

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Sixth Annual Intensive Update in Neurology 0915-162016

43

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Answer 2 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

44

Acute Vestibular Syndrome

bull Usually peripheral and can be associated with

hearing loss (labyrinthitis)

bull Timely diagnosis improves recovery (ASAP

prednisone 1mgkgday for ten days and taper 10

mgday ndash Strupp M 2004 NEJM)

bull Avoid vestibular suppressants after 3 days and begin

vestibular rehabilitation to hasten compensation

Sixth Annual Intensive Update in Neurology 0915-162016

45

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

46

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Answer 5 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

47

Menierersquos syndrome

bull Fluctuating low frequency hearing loss

bull Tinnitus andor aural fullness

bull Vertigo lasting hours

Sixth Annual Intensive Update in Neurology 0915-162016

48

Normal

Sixth Annual Intensive Update in Neurology 0915-162016

49

Hydrops

Sixth Annual Intensive Update in Neurology 0915-162016

50

Menierersquos syndrome

ndash Diagnosis- Exclusion (RO acoustic)

ndash 23 of Menierersquos patients will improve spontaneously

ndash Treatment-1500 mgday low sodium triamterene375-

hydrochlorothiazide 25 vestibular suppressants (lorazepam

1 mg tablet sublingual Q 8 prn attacks) off label use

Sixth Annual Intensive Update in Neurology 0915-162016

51

Menierersquos syndrome ndash intratympanic steroids

ndash A newer treatment option for those failing medical management

ndash 90 response rate (Boleus-Aguirre MS Otology Neurotology

2008)

ndash Outcomes data confirm excellent clinical response in 3941

Menierersquos patients treated with intratympanic steroids in 2008

Sixth Annual Intensive Update in Neurology 0915-162016

52

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

53

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Answer 5 See references at end

Sixth Annual Intensive Update in Neurology 0915-162016

54

Superior Semicircular Canal Dehiscence (SSCD)

bull Sound andor pressure induced oscillopsia

bull CT reformatted in the plane of the superior canals

shows dehiscence of overlying bone

bull Low frequency ldquoconductive hyperacusisrdquo with elevated

bone thresholds normal reflexes and a conductive loss

Sixth Annual Intensive Update in Neurology 0915-162016

55

SSCD

bull Positive middle ear pressure or loud sound stimulates ampullofugal endolymph flow -canal activation

bull Eye movements are tonic upwards with ipsilateral intorsion

Sixth Annual Intensive Update in Neurology 0915-162016

56

SSCD

bull Valsalva against a closed glottis or jugular compression causes increased intracranial pressure and ampullopetal endolymph flow -canal inhibition

bull Eye movements are tonic downwards with ipsilateral extorsion

Sixth Annual Intensive Update in Neurology 0915-162016

57

Reconstructed left superior semicircular canal

Sixth Annual Intensive Update in Neurology 0915-162016

58

Sixth Annual Intensive Update in Neurology 0915-162016

59

SCHEMATIC DRAWING OF AN OTOLITHIC MACULA

Sixth Annual Intensive Update in Neurology 0915-162016

60

MACULAE OF THE UTRICLESACCULE

Sixth Annual Intensive Update in Neurology 0915-162016

61

HAIR CELLS

Sixth Annual Intensive Update in Neurology 0915-162016

62

SCANNING ELECTRON MICROGRAPH OF OTOCONIA

Sixth Annual Intensive Update in Neurology 0915-162016

63

Ocular VEMP

bull Response to loud clicks (80-110 dB) or forehead tap (Halmagyi and Curthoys 2003)

bull Contralateral oculomotor nucleus (CN III)

bull Inferior oblique muscle contraction (8 msec) detected by 5sec event triggered averaging

bull Noninverting electrode inferior to eye

bull Inverting below non-inverting electrode

bull Ground to forehead

bull Normal subjects have very low response

Sixth Annual Intensive Update in Neurology 0915-162016

64

Clinical applications

bull The o-VEMP is a sensitive test of otolithutricular

function

bull Complements vestibular test procedures that assess

semicircular canals

bull Abnormally robust responses are associated with third

window abnormalities such as semicircular canal

dehiscence

bull Serves as an excellent screening test for semicircular

canal dehiscence

Sixth Annual Intensive Update in Neurology 0915-162016

65

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Sixth Annual Intensive Update in Neurology 0915-162016

66

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Answer 1 References at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

67

Enlarged vestibular aqueduct

bull Axial temporal bone CT showing right temporal bone with enlarged vestibular aqueduct (arrow)

bull Vestibular symptoms accompany progressive sensorineural hearing loss in 4-50 of patients in selected series

Sixth Annual Intensive Update in Neurology 0915-162016

68

Migraine

bull Family or personal history of migraine

bull 25 of migraine patients experience spontaneous vertigo (Baloh 1997)

bull Neuhauser criteria(2001) have been used to construct structured diagnostic interviews (Furman 2003)

bull Not always associated with headache

bull Motion sensitivity

bull Medication responsive

Sixth Annual Intensive Update in Neurology 0915-162016

69

ICHD-III beta Criteria for Vestibular Migraine

bull A At least five attacks fulfilling criteria C and D

bull B A current or past history of 11 migraine without aura or 12 migraine with aura

bull C Vestibular symptoms of moderate or severe intensity lasting between 5 minutes and 72 hours

bull D At least 50 associated with one of the following migrainous features

ndash 1 Headaches

ndash 2 Photophobia and phonophobia

ndash 3 Visual Aura

bull E Not better accounted for by another vestibular disorder

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 23: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

23

Supine Positional Tests

Sixth Annual Intensive Update in Neurology 0915-162016

24

Lateral SCC-BPPV

bull Short latency horizontal nystagmus provoked by supine bilateral head turns with prolonged duration and poor fatigability

bull Uncommon (2-15 of total BPPV)

bull Two formsndash Geotropic ndash beating towards undermost ear

ndash Apogeotropic ndash beating away from undermost ear

Sixth Annual Intensive Update in Neurology 0915-162016

25

Geotropic Lateral Canal BPPV

bull Patient is positioned

first to the right lateral

position ndash nystagmus

beats right

bull Patient is then

positioned to the left

lateral position and

nystagmus reverses

and beats left

Sixth Annual Intensive Update in Neurology 0915-162016

26

Left Geotropic Lateral Semicircular Canal BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

27

Repositioning Maneuvers for Geotropic Lateral Semicircular Canal (LSC) BPPV

bull Roll maneuver (Lempert Baloh)

ndash Patient rolls in 90 degree increments towards the good side

completely rolling over R LSC-BPPV repositioning shown

Sixth Annual Intensive Update in Neurology 0915-162016

28

Repositioning Maneuvers for Geotropic LSC BPPV

bull Gufoni maneuver

ndash Patient lies quickly onto good side and turns face-down to

floor for two minutes

Sixth Annual Intensive Update in Neurology 0915-162016

29

Left Apogeotropic LSC BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

30

Nystagmus observed During Repositioning

bull Nystagmus should remain in the same torsional

direction as seen on DHT throughout the treatment of

posterior BPPV

bull Reversal of nystagmus direction suggests the particle

has fallen back into the canal and predicts failure

bull In Lateral BPPV nystagmus should beat towards the

good ear

Sixth Annual Intensive Update in Neurology 0915-162016

31

Posterior to Lateral canal conversion

Sixth Annual Intensive Update in Neurology 0915-162016

32

R Posterior to Lateral Canal conversion - geotropic

Sixth Annual Intensive Update in Neurology 0915-162016

33

BPPV Recurrence

bull Recurrence is common (15yr)

bull Otoconial adherence or mineralization demineralization

abnormalities may contribute to recurrence

bull Home canalith repositioning is effective (Radke 2004)

Sixth Annual Intensive Update in Neurology 0915-162016

34

Question 1

bull The most likely semicircular canal to be affected in

BPPV is

ndash 1) superior

ndash 2) lateral

ndash 3) posterior

ndash 4) combined

Sixth Annual Intensive Update in Neurology 0915-162016

35

Question 1

bull The most likely semicircular canal to be affected in

BPPV is

ndash 1) superior

ndash 2) lateral

ndash 3) posterior

ndash 4) combined

Answer 3 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

36

Acute Vestibular Syndrome

bull Rapid unilateral injury to either peripheral or central

vestibular structures produces prolonged vertigo

(days to weeks)

bull Severe vertigo nausea and vomiting spontaneous

nystagmus and postural instability

Sixth Annual Intensive Update in Neurology 0915-162016

37

Acute Vestibular Syndrome

bull 25 of patients with risk factors who present with isolated severe vertigo nystagmus and postural instability in the ER have an acute infarction of the inferior cerebellum (AICA PICA) Central imaging is suggested (Baloh 1998 NEJM)

ndash HTN diabetes smoking age gt65 Afib valvular heart disease occlusive vascular disease

Sixth Annual Intensive Update in Neurology 0915-162016

38

HINTS test

bull Head Impulse

bull Nystagmus

bull Test of Skew

ndash More sensitive than MRI in the diagnosis of acute stroke in

patients with acute vestibular syndrome with at least one risk

factor (Kattah J et al Stroke 2009)

Sixth Annual Intensive Update in Neurology 0915-162016

39

Head Impulse Test

bull No special equipment needed

bull Examiner stands in front of seated patient and

randomly moves head left and right Patient is asked to

focus on examinerrsquos nose

bull Rapid low amplitude thrust from lateral to straight

ahead causes a compensatory saccade when

performed towards the weak side

bull This finding is a permanent feature of unilateral

vestibular loss

Sixth Annual Intensive Update in Neurology 0915-162016

40

Head Impulse Test

Sixth Annual Intensive Update in Neurology 0915-162016

41

Head CT ndash Academy of Emergency Medicine 2013

bull The clinical value of head CT in isolated

dizzinessvertigo without any associated neurological

symptoms is very low

bull Less than 1 of head CTs ordered for dizziness and

vertigo have significant abnormalities and those

patients had severe headache and neurological deficits

in addition to dizziness

bull Forgoing unnecessary emergency head CTs could

save 360 million dollars annually

Sixth Annual Intensive Update in Neurology 0915-162016

42

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Sixth Annual Intensive Update in Neurology 0915-162016

43

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Answer 2 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

44

Acute Vestibular Syndrome

bull Usually peripheral and can be associated with

hearing loss (labyrinthitis)

bull Timely diagnosis improves recovery (ASAP

prednisone 1mgkgday for ten days and taper 10

mgday ndash Strupp M 2004 NEJM)

bull Avoid vestibular suppressants after 3 days and begin

vestibular rehabilitation to hasten compensation

Sixth Annual Intensive Update in Neurology 0915-162016

45

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

46

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Answer 5 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

47

Menierersquos syndrome

bull Fluctuating low frequency hearing loss

bull Tinnitus andor aural fullness

bull Vertigo lasting hours

Sixth Annual Intensive Update in Neurology 0915-162016

48

Normal

Sixth Annual Intensive Update in Neurology 0915-162016

49

Hydrops

Sixth Annual Intensive Update in Neurology 0915-162016

50

Menierersquos syndrome

ndash Diagnosis- Exclusion (RO acoustic)

ndash 23 of Menierersquos patients will improve spontaneously

ndash Treatment-1500 mgday low sodium triamterene375-

hydrochlorothiazide 25 vestibular suppressants (lorazepam

1 mg tablet sublingual Q 8 prn attacks) off label use

Sixth Annual Intensive Update in Neurology 0915-162016

51

Menierersquos syndrome ndash intratympanic steroids

ndash A newer treatment option for those failing medical management

ndash 90 response rate (Boleus-Aguirre MS Otology Neurotology

2008)

ndash Outcomes data confirm excellent clinical response in 3941

Menierersquos patients treated with intratympanic steroids in 2008

Sixth Annual Intensive Update in Neurology 0915-162016

52

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

53

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Answer 5 See references at end

Sixth Annual Intensive Update in Neurology 0915-162016

54

Superior Semicircular Canal Dehiscence (SSCD)

bull Sound andor pressure induced oscillopsia

bull CT reformatted in the plane of the superior canals

shows dehiscence of overlying bone

bull Low frequency ldquoconductive hyperacusisrdquo with elevated

bone thresholds normal reflexes and a conductive loss

Sixth Annual Intensive Update in Neurology 0915-162016

55

SSCD

bull Positive middle ear pressure or loud sound stimulates ampullofugal endolymph flow -canal activation

bull Eye movements are tonic upwards with ipsilateral intorsion

Sixth Annual Intensive Update in Neurology 0915-162016

56

SSCD

bull Valsalva against a closed glottis or jugular compression causes increased intracranial pressure and ampullopetal endolymph flow -canal inhibition

bull Eye movements are tonic downwards with ipsilateral extorsion

Sixth Annual Intensive Update in Neurology 0915-162016

57

Reconstructed left superior semicircular canal

Sixth Annual Intensive Update in Neurology 0915-162016

58

Sixth Annual Intensive Update in Neurology 0915-162016

59

SCHEMATIC DRAWING OF AN OTOLITHIC MACULA

Sixth Annual Intensive Update in Neurology 0915-162016

60

MACULAE OF THE UTRICLESACCULE

Sixth Annual Intensive Update in Neurology 0915-162016

61

HAIR CELLS

Sixth Annual Intensive Update in Neurology 0915-162016

62

SCANNING ELECTRON MICROGRAPH OF OTOCONIA

Sixth Annual Intensive Update in Neurology 0915-162016

63

Ocular VEMP

bull Response to loud clicks (80-110 dB) or forehead tap (Halmagyi and Curthoys 2003)

bull Contralateral oculomotor nucleus (CN III)

bull Inferior oblique muscle contraction (8 msec) detected by 5sec event triggered averaging

bull Noninverting electrode inferior to eye

bull Inverting below non-inverting electrode

bull Ground to forehead

bull Normal subjects have very low response

Sixth Annual Intensive Update in Neurology 0915-162016

64

Clinical applications

bull The o-VEMP is a sensitive test of otolithutricular

function

bull Complements vestibular test procedures that assess

semicircular canals

bull Abnormally robust responses are associated with third

window abnormalities such as semicircular canal

dehiscence

bull Serves as an excellent screening test for semicircular

canal dehiscence

Sixth Annual Intensive Update in Neurology 0915-162016

65

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Sixth Annual Intensive Update in Neurology 0915-162016

66

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Answer 1 References at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

67

Enlarged vestibular aqueduct

bull Axial temporal bone CT showing right temporal bone with enlarged vestibular aqueduct (arrow)

bull Vestibular symptoms accompany progressive sensorineural hearing loss in 4-50 of patients in selected series

Sixth Annual Intensive Update in Neurology 0915-162016

68

Migraine

bull Family or personal history of migraine

bull 25 of migraine patients experience spontaneous vertigo (Baloh 1997)

bull Neuhauser criteria(2001) have been used to construct structured diagnostic interviews (Furman 2003)

bull Not always associated with headache

bull Motion sensitivity

bull Medication responsive

Sixth Annual Intensive Update in Neurology 0915-162016

69

ICHD-III beta Criteria for Vestibular Migraine

bull A At least five attacks fulfilling criteria C and D

bull B A current or past history of 11 migraine without aura or 12 migraine with aura

bull C Vestibular symptoms of moderate or severe intensity lasting between 5 minutes and 72 hours

bull D At least 50 associated with one of the following migrainous features

ndash 1 Headaches

ndash 2 Photophobia and phonophobia

ndash 3 Visual Aura

bull E Not better accounted for by another vestibular disorder

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 24: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

24

Lateral SCC-BPPV

bull Short latency horizontal nystagmus provoked by supine bilateral head turns with prolonged duration and poor fatigability

bull Uncommon (2-15 of total BPPV)

bull Two formsndash Geotropic ndash beating towards undermost ear

ndash Apogeotropic ndash beating away from undermost ear

Sixth Annual Intensive Update in Neurology 0915-162016

25

Geotropic Lateral Canal BPPV

bull Patient is positioned

first to the right lateral

position ndash nystagmus

beats right

bull Patient is then

positioned to the left

lateral position and

nystagmus reverses

and beats left

Sixth Annual Intensive Update in Neurology 0915-162016

26

Left Geotropic Lateral Semicircular Canal BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

27

Repositioning Maneuvers for Geotropic Lateral Semicircular Canal (LSC) BPPV

bull Roll maneuver (Lempert Baloh)

ndash Patient rolls in 90 degree increments towards the good side

completely rolling over R LSC-BPPV repositioning shown

Sixth Annual Intensive Update in Neurology 0915-162016

28

Repositioning Maneuvers for Geotropic LSC BPPV

bull Gufoni maneuver

ndash Patient lies quickly onto good side and turns face-down to

floor for two minutes

Sixth Annual Intensive Update in Neurology 0915-162016

29

Left Apogeotropic LSC BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

30

Nystagmus observed During Repositioning

bull Nystagmus should remain in the same torsional

direction as seen on DHT throughout the treatment of

posterior BPPV

bull Reversal of nystagmus direction suggests the particle

has fallen back into the canal and predicts failure

bull In Lateral BPPV nystagmus should beat towards the

good ear

Sixth Annual Intensive Update in Neurology 0915-162016

31

Posterior to Lateral canal conversion

Sixth Annual Intensive Update in Neurology 0915-162016

32

R Posterior to Lateral Canal conversion - geotropic

Sixth Annual Intensive Update in Neurology 0915-162016

33

BPPV Recurrence

bull Recurrence is common (15yr)

bull Otoconial adherence or mineralization demineralization

abnormalities may contribute to recurrence

bull Home canalith repositioning is effective (Radke 2004)

Sixth Annual Intensive Update in Neurology 0915-162016

34

Question 1

bull The most likely semicircular canal to be affected in

BPPV is

ndash 1) superior

ndash 2) lateral

ndash 3) posterior

ndash 4) combined

Sixth Annual Intensive Update in Neurology 0915-162016

35

Question 1

bull The most likely semicircular canal to be affected in

BPPV is

ndash 1) superior

ndash 2) lateral

ndash 3) posterior

ndash 4) combined

Answer 3 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

36

Acute Vestibular Syndrome

bull Rapid unilateral injury to either peripheral or central

vestibular structures produces prolonged vertigo

(days to weeks)

bull Severe vertigo nausea and vomiting spontaneous

nystagmus and postural instability

Sixth Annual Intensive Update in Neurology 0915-162016

37

Acute Vestibular Syndrome

bull 25 of patients with risk factors who present with isolated severe vertigo nystagmus and postural instability in the ER have an acute infarction of the inferior cerebellum (AICA PICA) Central imaging is suggested (Baloh 1998 NEJM)

ndash HTN diabetes smoking age gt65 Afib valvular heart disease occlusive vascular disease

Sixth Annual Intensive Update in Neurology 0915-162016

38

HINTS test

bull Head Impulse

bull Nystagmus

bull Test of Skew

ndash More sensitive than MRI in the diagnosis of acute stroke in

patients with acute vestibular syndrome with at least one risk

factor (Kattah J et al Stroke 2009)

Sixth Annual Intensive Update in Neurology 0915-162016

39

Head Impulse Test

bull No special equipment needed

bull Examiner stands in front of seated patient and

randomly moves head left and right Patient is asked to

focus on examinerrsquos nose

bull Rapid low amplitude thrust from lateral to straight

ahead causes a compensatory saccade when

performed towards the weak side

bull This finding is a permanent feature of unilateral

vestibular loss

Sixth Annual Intensive Update in Neurology 0915-162016

40

Head Impulse Test

Sixth Annual Intensive Update in Neurology 0915-162016

41

Head CT ndash Academy of Emergency Medicine 2013

bull The clinical value of head CT in isolated

dizzinessvertigo without any associated neurological

symptoms is very low

bull Less than 1 of head CTs ordered for dizziness and

vertigo have significant abnormalities and those

patients had severe headache and neurological deficits

in addition to dizziness

bull Forgoing unnecessary emergency head CTs could

save 360 million dollars annually

Sixth Annual Intensive Update in Neurology 0915-162016

42

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Sixth Annual Intensive Update in Neurology 0915-162016

43

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Answer 2 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

44

Acute Vestibular Syndrome

bull Usually peripheral and can be associated with

hearing loss (labyrinthitis)

bull Timely diagnosis improves recovery (ASAP

prednisone 1mgkgday for ten days and taper 10

mgday ndash Strupp M 2004 NEJM)

bull Avoid vestibular suppressants after 3 days and begin

vestibular rehabilitation to hasten compensation

Sixth Annual Intensive Update in Neurology 0915-162016

45

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

46

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Answer 5 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

47

Menierersquos syndrome

bull Fluctuating low frequency hearing loss

bull Tinnitus andor aural fullness

bull Vertigo lasting hours

Sixth Annual Intensive Update in Neurology 0915-162016

48

Normal

Sixth Annual Intensive Update in Neurology 0915-162016

49

Hydrops

Sixth Annual Intensive Update in Neurology 0915-162016

50

Menierersquos syndrome

ndash Diagnosis- Exclusion (RO acoustic)

ndash 23 of Menierersquos patients will improve spontaneously

ndash Treatment-1500 mgday low sodium triamterene375-

hydrochlorothiazide 25 vestibular suppressants (lorazepam

1 mg tablet sublingual Q 8 prn attacks) off label use

Sixth Annual Intensive Update in Neurology 0915-162016

51

Menierersquos syndrome ndash intratympanic steroids

ndash A newer treatment option for those failing medical management

ndash 90 response rate (Boleus-Aguirre MS Otology Neurotology

2008)

ndash Outcomes data confirm excellent clinical response in 3941

Menierersquos patients treated with intratympanic steroids in 2008

Sixth Annual Intensive Update in Neurology 0915-162016

52

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

53

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Answer 5 See references at end

Sixth Annual Intensive Update in Neurology 0915-162016

54

Superior Semicircular Canal Dehiscence (SSCD)

bull Sound andor pressure induced oscillopsia

bull CT reformatted in the plane of the superior canals

shows dehiscence of overlying bone

bull Low frequency ldquoconductive hyperacusisrdquo with elevated

bone thresholds normal reflexes and a conductive loss

Sixth Annual Intensive Update in Neurology 0915-162016

55

SSCD

bull Positive middle ear pressure or loud sound stimulates ampullofugal endolymph flow -canal activation

bull Eye movements are tonic upwards with ipsilateral intorsion

Sixth Annual Intensive Update in Neurology 0915-162016

56

SSCD

bull Valsalva against a closed glottis or jugular compression causes increased intracranial pressure and ampullopetal endolymph flow -canal inhibition

bull Eye movements are tonic downwards with ipsilateral extorsion

Sixth Annual Intensive Update in Neurology 0915-162016

57

Reconstructed left superior semicircular canal

Sixth Annual Intensive Update in Neurology 0915-162016

58

Sixth Annual Intensive Update in Neurology 0915-162016

59

SCHEMATIC DRAWING OF AN OTOLITHIC MACULA

Sixth Annual Intensive Update in Neurology 0915-162016

60

MACULAE OF THE UTRICLESACCULE

Sixth Annual Intensive Update in Neurology 0915-162016

61

HAIR CELLS

Sixth Annual Intensive Update in Neurology 0915-162016

62

SCANNING ELECTRON MICROGRAPH OF OTOCONIA

Sixth Annual Intensive Update in Neurology 0915-162016

63

Ocular VEMP

bull Response to loud clicks (80-110 dB) or forehead tap (Halmagyi and Curthoys 2003)

bull Contralateral oculomotor nucleus (CN III)

bull Inferior oblique muscle contraction (8 msec) detected by 5sec event triggered averaging

bull Noninverting electrode inferior to eye

bull Inverting below non-inverting electrode

bull Ground to forehead

bull Normal subjects have very low response

Sixth Annual Intensive Update in Neurology 0915-162016

64

Clinical applications

bull The o-VEMP is a sensitive test of otolithutricular

function

bull Complements vestibular test procedures that assess

semicircular canals

bull Abnormally robust responses are associated with third

window abnormalities such as semicircular canal

dehiscence

bull Serves as an excellent screening test for semicircular

canal dehiscence

Sixth Annual Intensive Update in Neurology 0915-162016

65

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Sixth Annual Intensive Update in Neurology 0915-162016

66

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Answer 1 References at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

67

Enlarged vestibular aqueduct

bull Axial temporal bone CT showing right temporal bone with enlarged vestibular aqueduct (arrow)

bull Vestibular symptoms accompany progressive sensorineural hearing loss in 4-50 of patients in selected series

Sixth Annual Intensive Update in Neurology 0915-162016

68

Migraine

bull Family or personal history of migraine

bull 25 of migraine patients experience spontaneous vertigo (Baloh 1997)

bull Neuhauser criteria(2001) have been used to construct structured diagnostic interviews (Furman 2003)

bull Not always associated with headache

bull Motion sensitivity

bull Medication responsive

Sixth Annual Intensive Update in Neurology 0915-162016

69

ICHD-III beta Criteria for Vestibular Migraine

bull A At least five attacks fulfilling criteria C and D

bull B A current or past history of 11 migraine without aura or 12 migraine with aura

bull C Vestibular symptoms of moderate or severe intensity lasting between 5 minutes and 72 hours

bull D At least 50 associated with one of the following migrainous features

ndash 1 Headaches

ndash 2 Photophobia and phonophobia

ndash 3 Visual Aura

bull E Not better accounted for by another vestibular disorder

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 25: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

25

Geotropic Lateral Canal BPPV

bull Patient is positioned

first to the right lateral

position ndash nystagmus

beats right

bull Patient is then

positioned to the left

lateral position and

nystagmus reverses

and beats left

Sixth Annual Intensive Update in Neurology 0915-162016

26

Left Geotropic Lateral Semicircular Canal BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

27

Repositioning Maneuvers for Geotropic Lateral Semicircular Canal (LSC) BPPV

bull Roll maneuver (Lempert Baloh)

ndash Patient rolls in 90 degree increments towards the good side

completely rolling over R LSC-BPPV repositioning shown

Sixth Annual Intensive Update in Neurology 0915-162016

28

Repositioning Maneuvers for Geotropic LSC BPPV

bull Gufoni maneuver

ndash Patient lies quickly onto good side and turns face-down to

floor for two minutes

Sixth Annual Intensive Update in Neurology 0915-162016

29

Left Apogeotropic LSC BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

30

Nystagmus observed During Repositioning

bull Nystagmus should remain in the same torsional

direction as seen on DHT throughout the treatment of

posterior BPPV

bull Reversal of nystagmus direction suggests the particle

has fallen back into the canal and predicts failure

bull In Lateral BPPV nystagmus should beat towards the

good ear

Sixth Annual Intensive Update in Neurology 0915-162016

31

Posterior to Lateral canal conversion

Sixth Annual Intensive Update in Neurology 0915-162016

32

R Posterior to Lateral Canal conversion - geotropic

Sixth Annual Intensive Update in Neurology 0915-162016

33

BPPV Recurrence

bull Recurrence is common (15yr)

bull Otoconial adherence or mineralization demineralization

abnormalities may contribute to recurrence

bull Home canalith repositioning is effective (Radke 2004)

Sixth Annual Intensive Update in Neurology 0915-162016

34

Question 1

bull The most likely semicircular canal to be affected in

BPPV is

ndash 1) superior

ndash 2) lateral

ndash 3) posterior

ndash 4) combined

Sixth Annual Intensive Update in Neurology 0915-162016

35

Question 1

bull The most likely semicircular canal to be affected in

BPPV is

ndash 1) superior

ndash 2) lateral

ndash 3) posterior

ndash 4) combined

Answer 3 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

36

Acute Vestibular Syndrome

bull Rapid unilateral injury to either peripheral or central

vestibular structures produces prolonged vertigo

(days to weeks)

bull Severe vertigo nausea and vomiting spontaneous

nystagmus and postural instability

Sixth Annual Intensive Update in Neurology 0915-162016

37

Acute Vestibular Syndrome

bull 25 of patients with risk factors who present with isolated severe vertigo nystagmus and postural instability in the ER have an acute infarction of the inferior cerebellum (AICA PICA) Central imaging is suggested (Baloh 1998 NEJM)

ndash HTN diabetes smoking age gt65 Afib valvular heart disease occlusive vascular disease

Sixth Annual Intensive Update in Neurology 0915-162016

38

HINTS test

bull Head Impulse

bull Nystagmus

bull Test of Skew

ndash More sensitive than MRI in the diagnosis of acute stroke in

patients with acute vestibular syndrome with at least one risk

factor (Kattah J et al Stroke 2009)

Sixth Annual Intensive Update in Neurology 0915-162016

39

Head Impulse Test

bull No special equipment needed

bull Examiner stands in front of seated patient and

randomly moves head left and right Patient is asked to

focus on examinerrsquos nose

bull Rapid low amplitude thrust from lateral to straight

ahead causes a compensatory saccade when

performed towards the weak side

bull This finding is a permanent feature of unilateral

vestibular loss

Sixth Annual Intensive Update in Neurology 0915-162016

40

Head Impulse Test

Sixth Annual Intensive Update in Neurology 0915-162016

41

Head CT ndash Academy of Emergency Medicine 2013

bull The clinical value of head CT in isolated

dizzinessvertigo without any associated neurological

symptoms is very low

bull Less than 1 of head CTs ordered for dizziness and

vertigo have significant abnormalities and those

patients had severe headache and neurological deficits

in addition to dizziness

bull Forgoing unnecessary emergency head CTs could

save 360 million dollars annually

Sixth Annual Intensive Update in Neurology 0915-162016

42

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Sixth Annual Intensive Update in Neurology 0915-162016

43

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Answer 2 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

44

Acute Vestibular Syndrome

bull Usually peripheral and can be associated with

hearing loss (labyrinthitis)

bull Timely diagnosis improves recovery (ASAP

prednisone 1mgkgday for ten days and taper 10

mgday ndash Strupp M 2004 NEJM)

bull Avoid vestibular suppressants after 3 days and begin

vestibular rehabilitation to hasten compensation

Sixth Annual Intensive Update in Neurology 0915-162016

45

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

46

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Answer 5 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

47

Menierersquos syndrome

bull Fluctuating low frequency hearing loss

bull Tinnitus andor aural fullness

bull Vertigo lasting hours

Sixth Annual Intensive Update in Neurology 0915-162016

48

Normal

Sixth Annual Intensive Update in Neurology 0915-162016

49

Hydrops

Sixth Annual Intensive Update in Neurology 0915-162016

50

Menierersquos syndrome

ndash Diagnosis- Exclusion (RO acoustic)

ndash 23 of Menierersquos patients will improve spontaneously

ndash Treatment-1500 mgday low sodium triamterene375-

hydrochlorothiazide 25 vestibular suppressants (lorazepam

1 mg tablet sublingual Q 8 prn attacks) off label use

Sixth Annual Intensive Update in Neurology 0915-162016

51

Menierersquos syndrome ndash intratympanic steroids

ndash A newer treatment option for those failing medical management

ndash 90 response rate (Boleus-Aguirre MS Otology Neurotology

2008)

ndash Outcomes data confirm excellent clinical response in 3941

Menierersquos patients treated with intratympanic steroids in 2008

Sixth Annual Intensive Update in Neurology 0915-162016

52

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

53

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Answer 5 See references at end

Sixth Annual Intensive Update in Neurology 0915-162016

54

Superior Semicircular Canal Dehiscence (SSCD)

bull Sound andor pressure induced oscillopsia

bull CT reformatted in the plane of the superior canals

shows dehiscence of overlying bone

bull Low frequency ldquoconductive hyperacusisrdquo with elevated

bone thresholds normal reflexes and a conductive loss

Sixth Annual Intensive Update in Neurology 0915-162016

55

SSCD

bull Positive middle ear pressure or loud sound stimulates ampullofugal endolymph flow -canal activation

bull Eye movements are tonic upwards with ipsilateral intorsion

Sixth Annual Intensive Update in Neurology 0915-162016

56

SSCD

bull Valsalva against a closed glottis or jugular compression causes increased intracranial pressure and ampullopetal endolymph flow -canal inhibition

bull Eye movements are tonic downwards with ipsilateral extorsion

Sixth Annual Intensive Update in Neurology 0915-162016

57

Reconstructed left superior semicircular canal

Sixth Annual Intensive Update in Neurology 0915-162016

58

Sixth Annual Intensive Update in Neurology 0915-162016

59

SCHEMATIC DRAWING OF AN OTOLITHIC MACULA

Sixth Annual Intensive Update in Neurology 0915-162016

60

MACULAE OF THE UTRICLESACCULE

Sixth Annual Intensive Update in Neurology 0915-162016

61

HAIR CELLS

Sixth Annual Intensive Update in Neurology 0915-162016

62

SCANNING ELECTRON MICROGRAPH OF OTOCONIA

Sixth Annual Intensive Update in Neurology 0915-162016

63

Ocular VEMP

bull Response to loud clicks (80-110 dB) or forehead tap (Halmagyi and Curthoys 2003)

bull Contralateral oculomotor nucleus (CN III)

bull Inferior oblique muscle contraction (8 msec) detected by 5sec event triggered averaging

bull Noninverting electrode inferior to eye

bull Inverting below non-inverting electrode

bull Ground to forehead

bull Normal subjects have very low response

Sixth Annual Intensive Update in Neurology 0915-162016

64

Clinical applications

bull The o-VEMP is a sensitive test of otolithutricular

function

bull Complements vestibular test procedures that assess

semicircular canals

bull Abnormally robust responses are associated with third

window abnormalities such as semicircular canal

dehiscence

bull Serves as an excellent screening test for semicircular

canal dehiscence

Sixth Annual Intensive Update in Neurology 0915-162016

65

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Sixth Annual Intensive Update in Neurology 0915-162016

66

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Answer 1 References at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

67

Enlarged vestibular aqueduct

bull Axial temporal bone CT showing right temporal bone with enlarged vestibular aqueduct (arrow)

bull Vestibular symptoms accompany progressive sensorineural hearing loss in 4-50 of patients in selected series

Sixth Annual Intensive Update in Neurology 0915-162016

68

Migraine

bull Family or personal history of migraine

bull 25 of migraine patients experience spontaneous vertigo (Baloh 1997)

bull Neuhauser criteria(2001) have been used to construct structured diagnostic interviews (Furman 2003)

bull Not always associated with headache

bull Motion sensitivity

bull Medication responsive

Sixth Annual Intensive Update in Neurology 0915-162016

69

ICHD-III beta Criteria for Vestibular Migraine

bull A At least five attacks fulfilling criteria C and D

bull B A current or past history of 11 migraine without aura or 12 migraine with aura

bull C Vestibular symptoms of moderate or severe intensity lasting between 5 minutes and 72 hours

bull D At least 50 associated with one of the following migrainous features

ndash 1 Headaches

ndash 2 Photophobia and phonophobia

ndash 3 Visual Aura

bull E Not better accounted for by another vestibular disorder

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 26: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

26

Left Geotropic Lateral Semicircular Canal BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

27

Repositioning Maneuvers for Geotropic Lateral Semicircular Canal (LSC) BPPV

bull Roll maneuver (Lempert Baloh)

ndash Patient rolls in 90 degree increments towards the good side

completely rolling over R LSC-BPPV repositioning shown

Sixth Annual Intensive Update in Neurology 0915-162016

28

Repositioning Maneuvers for Geotropic LSC BPPV

bull Gufoni maneuver

ndash Patient lies quickly onto good side and turns face-down to

floor for two minutes

Sixth Annual Intensive Update in Neurology 0915-162016

29

Left Apogeotropic LSC BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

30

Nystagmus observed During Repositioning

bull Nystagmus should remain in the same torsional

direction as seen on DHT throughout the treatment of

posterior BPPV

bull Reversal of nystagmus direction suggests the particle

has fallen back into the canal and predicts failure

bull In Lateral BPPV nystagmus should beat towards the

good ear

Sixth Annual Intensive Update in Neurology 0915-162016

31

Posterior to Lateral canal conversion

Sixth Annual Intensive Update in Neurology 0915-162016

32

R Posterior to Lateral Canal conversion - geotropic

Sixth Annual Intensive Update in Neurology 0915-162016

33

BPPV Recurrence

bull Recurrence is common (15yr)

bull Otoconial adherence or mineralization demineralization

abnormalities may contribute to recurrence

bull Home canalith repositioning is effective (Radke 2004)

Sixth Annual Intensive Update in Neurology 0915-162016

34

Question 1

bull The most likely semicircular canal to be affected in

BPPV is

ndash 1) superior

ndash 2) lateral

ndash 3) posterior

ndash 4) combined

Sixth Annual Intensive Update in Neurology 0915-162016

35

Question 1

bull The most likely semicircular canal to be affected in

BPPV is

ndash 1) superior

ndash 2) lateral

ndash 3) posterior

ndash 4) combined

Answer 3 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

36

Acute Vestibular Syndrome

bull Rapid unilateral injury to either peripheral or central

vestibular structures produces prolonged vertigo

(days to weeks)

bull Severe vertigo nausea and vomiting spontaneous

nystagmus and postural instability

Sixth Annual Intensive Update in Neurology 0915-162016

37

Acute Vestibular Syndrome

bull 25 of patients with risk factors who present with isolated severe vertigo nystagmus and postural instability in the ER have an acute infarction of the inferior cerebellum (AICA PICA) Central imaging is suggested (Baloh 1998 NEJM)

ndash HTN diabetes smoking age gt65 Afib valvular heart disease occlusive vascular disease

Sixth Annual Intensive Update in Neurology 0915-162016

38

HINTS test

bull Head Impulse

bull Nystagmus

bull Test of Skew

ndash More sensitive than MRI in the diagnosis of acute stroke in

patients with acute vestibular syndrome with at least one risk

factor (Kattah J et al Stroke 2009)

Sixth Annual Intensive Update in Neurology 0915-162016

39

Head Impulse Test

bull No special equipment needed

bull Examiner stands in front of seated patient and

randomly moves head left and right Patient is asked to

focus on examinerrsquos nose

bull Rapid low amplitude thrust from lateral to straight

ahead causes a compensatory saccade when

performed towards the weak side

bull This finding is a permanent feature of unilateral

vestibular loss

Sixth Annual Intensive Update in Neurology 0915-162016

40

Head Impulse Test

Sixth Annual Intensive Update in Neurology 0915-162016

41

Head CT ndash Academy of Emergency Medicine 2013

bull The clinical value of head CT in isolated

dizzinessvertigo without any associated neurological

symptoms is very low

bull Less than 1 of head CTs ordered for dizziness and

vertigo have significant abnormalities and those

patients had severe headache and neurological deficits

in addition to dizziness

bull Forgoing unnecessary emergency head CTs could

save 360 million dollars annually

Sixth Annual Intensive Update in Neurology 0915-162016

42

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Sixth Annual Intensive Update in Neurology 0915-162016

43

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Answer 2 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

44

Acute Vestibular Syndrome

bull Usually peripheral and can be associated with

hearing loss (labyrinthitis)

bull Timely diagnosis improves recovery (ASAP

prednisone 1mgkgday for ten days and taper 10

mgday ndash Strupp M 2004 NEJM)

bull Avoid vestibular suppressants after 3 days and begin

vestibular rehabilitation to hasten compensation

Sixth Annual Intensive Update in Neurology 0915-162016

45

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

46

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Answer 5 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

47

Menierersquos syndrome

bull Fluctuating low frequency hearing loss

bull Tinnitus andor aural fullness

bull Vertigo lasting hours

Sixth Annual Intensive Update in Neurology 0915-162016

48

Normal

Sixth Annual Intensive Update in Neurology 0915-162016

49

Hydrops

Sixth Annual Intensive Update in Neurology 0915-162016

50

Menierersquos syndrome

ndash Diagnosis- Exclusion (RO acoustic)

ndash 23 of Menierersquos patients will improve spontaneously

ndash Treatment-1500 mgday low sodium triamterene375-

hydrochlorothiazide 25 vestibular suppressants (lorazepam

1 mg tablet sublingual Q 8 prn attacks) off label use

Sixth Annual Intensive Update in Neurology 0915-162016

51

Menierersquos syndrome ndash intratympanic steroids

ndash A newer treatment option for those failing medical management

ndash 90 response rate (Boleus-Aguirre MS Otology Neurotology

2008)

ndash Outcomes data confirm excellent clinical response in 3941

Menierersquos patients treated with intratympanic steroids in 2008

Sixth Annual Intensive Update in Neurology 0915-162016

52

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

53

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Answer 5 See references at end

Sixth Annual Intensive Update in Neurology 0915-162016

54

Superior Semicircular Canal Dehiscence (SSCD)

bull Sound andor pressure induced oscillopsia

bull CT reformatted in the plane of the superior canals

shows dehiscence of overlying bone

bull Low frequency ldquoconductive hyperacusisrdquo with elevated

bone thresholds normal reflexes and a conductive loss

Sixth Annual Intensive Update in Neurology 0915-162016

55

SSCD

bull Positive middle ear pressure or loud sound stimulates ampullofugal endolymph flow -canal activation

bull Eye movements are tonic upwards with ipsilateral intorsion

Sixth Annual Intensive Update in Neurology 0915-162016

56

SSCD

bull Valsalva against a closed glottis or jugular compression causes increased intracranial pressure and ampullopetal endolymph flow -canal inhibition

bull Eye movements are tonic downwards with ipsilateral extorsion

Sixth Annual Intensive Update in Neurology 0915-162016

57

Reconstructed left superior semicircular canal

Sixth Annual Intensive Update in Neurology 0915-162016

58

Sixth Annual Intensive Update in Neurology 0915-162016

59

SCHEMATIC DRAWING OF AN OTOLITHIC MACULA

Sixth Annual Intensive Update in Neurology 0915-162016

60

MACULAE OF THE UTRICLESACCULE

Sixth Annual Intensive Update in Neurology 0915-162016

61

HAIR CELLS

Sixth Annual Intensive Update in Neurology 0915-162016

62

SCANNING ELECTRON MICROGRAPH OF OTOCONIA

Sixth Annual Intensive Update in Neurology 0915-162016

63

Ocular VEMP

bull Response to loud clicks (80-110 dB) or forehead tap (Halmagyi and Curthoys 2003)

bull Contralateral oculomotor nucleus (CN III)

bull Inferior oblique muscle contraction (8 msec) detected by 5sec event triggered averaging

bull Noninverting electrode inferior to eye

bull Inverting below non-inverting electrode

bull Ground to forehead

bull Normal subjects have very low response

Sixth Annual Intensive Update in Neurology 0915-162016

64

Clinical applications

bull The o-VEMP is a sensitive test of otolithutricular

function

bull Complements vestibular test procedures that assess

semicircular canals

bull Abnormally robust responses are associated with third

window abnormalities such as semicircular canal

dehiscence

bull Serves as an excellent screening test for semicircular

canal dehiscence

Sixth Annual Intensive Update in Neurology 0915-162016

65

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Sixth Annual Intensive Update in Neurology 0915-162016

66

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Answer 1 References at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

67

Enlarged vestibular aqueduct

bull Axial temporal bone CT showing right temporal bone with enlarged vestibular aqueduct (arrow)

bull Vestibular symptoms accompany progressive sensorineural hearing loss in 4-50 of patients in selected series

Sixth Annual Intensive Update in Neurology 0915-162016

68

Migraine

bull Family or personal history of migraine

bull 25 of migraine patients experience spontaneous vertigo (Baloh 1997)

bull Neuhauser criteria(2001) have been used to construct structured diagnostic interviews (Furman 2003)

bull Not always associated with headache

bull Motion sensitivity

bull Medication responsive

Sixth Annual Intensive Update in Neurology 0915-162016

69

ICHD-III beta Criteria for Vestibular Migraine

bull A At least five attacks fulfilling criteria C and D

bull B A current or past history of 11 migraine without aura or 12 migraine with aura

bull C Vestibular symptoms of moderate or severe intensity lasting between 5 minutes and 72 hours

bull D At least 50 associated with one of the following migrainous features

ndash 1 Headaches

ndash 2 Photophobia and phonophobia

ndash 3 Visual Aura

bull E Not better accounted for by another vestibular disorder

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 27: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

27

Repositioning Maneuvers for Geotropic Lateral Semicircular Canal (LSC) BPPV

bull Roll maneuver (Lempert Baloh)

ndash Patient rolls in 90 degree increments towards the good side

completely rolling over R LSC-BPPV repositioning shown

Sixth Annual Intensive Update in Neurology 0915-162016

28

Repositioning Maneuvers for Geotropic LSC BPPV

bull Gufoni maneuver

ndash Patient lies quickly onto good side and turns face-down to

floor for two minutes

Sixth Annual Intensive Update in Neurology 0915-162016

29

Left Apogeotropic LSC BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

30

Nystagmus observed During Repositioning

bull Nystagmus should remain in the same torsional

direction as seen on DHT throughout the treatment of

posterior BPPV

bull Reversal of nystagmus direction suggests the particle

has fallen back into the canal and predicts failure

bull In Lateral BPPV nystagmus should beat towards the

good ear

Sixth Annual Intensive Update in Neurology 0915-162016

31

Posterior to Lateral canal conversion

Sixth Annual Intensive Update in Neurology 0915-162016

32

R Posterior to Lateral Canal conversion - geotropic

Sixth Annual Intensive Update in Neurology 0915-162016

33

BPPV Recurrence

bull Recurrence is common (15yr)

bull Otoconial adherence or mineralization demineralization

abnormalities may contribute to recurrence

bull Home canalith repositioning is effective (Radke 2004)

Sixth Annual Intensive Update in Neurology 0915-162016

34

Question 1

bull The most likely semicircular canal to be affected in

BPPV is

ndash 1) superior

ndash 2) lateral

ndash 3) posterior

ndash 4) combined

Sixth Annual Intensive Update in Neurology 0915-162016

35

Question 1

bull The most likely semicircular canal to be affected in

BPPV is

ndash 1) superior

ndash 2) lateral

ndash 3) posterior

ndash 4) combined

Answer 3 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

36

Acute Vestibular Syndrome

bull Rapid unilateral injury to either peripheral or central

vestibular structures produces prolonged vertigo

(days to weeks)

bull Severe vertigo nausea and vomiting spontaneous

nystagmus and postural instability

Sixth Annual Intensive Update in Neurology 0915-162016

37

Acute Vestibular Syndrome

bull 25 of patients with risk factors who present with isolated severe vertigo nystagmus and postural instability in the ER have an acute infarction of the inferior cerebellum (AICA PICA) Central imaging is suggested (Baloh 1998 NEJM)

ndash HTN diabetes smoking age gt65 Afib valvular heart disease occlusive vascular disease

Sixth Annual Intensive Update in Neurology 0915-162016

38

HINTS test

bull Head Impulse

bull Nystagmus

bull Test of Skew

ndash More sensitive than MRI in the diagnosis of acute stroke in

patients with acute vestibular syndrome with at least one risk

factor (Kattah J et al Stroke 2009)

Sixth Annual Intensive Update in Neurology 0915-162016

39

Head Impulse Test

bull No special equipment needed

bull Examiner stands in front of seated patient and

randomly moves head left and right Patient is asked to

focus on examinerrsquos nose

bull Rapid low amplitude thrust from lateral to straight

ahead causes a compensatory saccade when

performed towards the weak side

bull This finding is a permanent feature of unilateral

vestibular loss

Sixth Annual Intensive Update in Neurology 0915-162016

40

Head Impulse Test

Sixth Annual Intensive Update in Neurology 0915-162016

41

Head CT ndash Academy of Emergency Medicine 2013

bull The clinical value of head CT in isolated

dizzinessvertigo without any associated neurological

symptoms is very low

bull Less than 1 of head CTs ordered for dizziness and

vertigo have significant abnormalities and those

patients had severe headache and neurological deficits

in addition to dizziness

bull Forgoing unnecessary emergency head CTs could

save 360 million dollars annually

Sixth Annual Intensive Update in Neurology 0915-162016

42

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Sixth Annual Intensive Update in Neurology 0915-162016

43

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Answer 2 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

44

Acute Vestibular Syndrome

bull Usually peripheral and can be associated with

hearing loss (labyrinthitis)

bull Timely diagnosis improves recovery (ASAP

prednisone 1mgkgday for ten days and taper 10

mgday ndash Strupp M 2004 NEJM)

bull Avoid vestibular suppressants after 3 days and begin

vestibular rehabilitation to hasten compensation

Sixth Annual Intensive Update in Neurology 0915-162016

45

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

46

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Answer 5 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

47

Menierersquos syndrome

bull Fluctuating low frequency hearing loss

bull Tinnitus andor aural fullness

bull Vertigo lasting hours

Sixth Annual Intensive Update in Neurology 0915-162016

48

Normal

Sixth Annual Intensive Update in Neurology 0915-162016

49

Hydrops

Sixth Annual Intensive Update in Neurology 0915-162016

50

Menierersquos syndrome

ndash Diagnosis- Exclusion (RO acoustic)

ndash 23 of Menierersquos patients will improve spontaneously

ndash Treatment-1500 mgday low sodium triamterene375-

hydrochlorothiazide 25 vestibular suppressants (lorazepam

1 mg tablet sublingual Q 8 prn attacks) off label use

Sixth Annual Intensive Update in Neurology 0915-162016

51

Menierersquos syndrome ndash intratympanic steroids

ndash A newer treatment option for those failing medical management

ndash 90 response rate (Boleus-Aguirre MS Otology Neurotology

2008)

ndash Outcomes data confirm excellent clinical response in 3941

Menierersquos patients treated with intratympanic steroids in 2008

Sixth Annual Intensive Update in Neurology 0915-162016

52

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

53

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Answer 5 See references at end

Sixth Annual Intensive Update in Neurology 0915-162016

54

Superior Semicircular Canal Dehiscence (SSCD)

bull Sound andor pressure induced oscillopsia

bull CT reformatted in the plane of the superior canals

shows dehiscence of overlying bone

bull Low frequency ldquoconductive hyperacusisrdquo with elevated

bone thresholds normal reflexes and a conductive loss

Sixth Annual Intensive Update in Neurology 0915-162016

55

SSCD

bull Positive middle ear pressure or loud sound stimulates ampullofugal endolymph flow -canal activation

bull Eye movements are tonic upwards with ipsilateral intorsion

Sixth Annual Intensive Update in Neurology 0915-162016

56

SSCD

bull Valsalva against a closed glottis or jugular compression causes increased intracranial pressure and ampullopetal endolymph flow -canal inhibition

bull Eye movements are tonic downwards with ipsilateral extorsion

Sixth Annual Intensive Update in Neurology 0915-162016

57

Reconstructed left superior semicircular canal

Sixth Annual Intensive Update in Neurology 0915-162016

58

Sixth Annual Intensive Update in Neurology 0915-162016

59

SCHEMATIC DRAWING OF AN OTOLITHIC MACULA

Sixth Annual Intensive Update in Neurology 0915-162016

60

MACULAE OF THE UTRICLESACCULE

Sixth Annual Intensive Update in Neurology 0915-162016

61

HAIR CELLS

Sixth Annual Intensive Update in Neurology 0915-162016

62

SCANNING ELECTRON MICROGRAPH OF OTOCONIA

Sixth Annual Intensive Update in Neurology 0915-162016

63

Ocular VEMP

bull Response to loud clicks (80-110 dB) or forehead tap (Halmagyi and Curthoys 2003)

bull Contralateral oculomotor nucleus (CN III)

bull Inferior oblique muscle contraction (8 msec) detected by 5sec event triggered averaging

bull Noninverting electrode inferior to eye

bull Inverting below non-inverting electrode

bull Ground to forehead

bull Normal subjects have very low response

Sixth Annual Intensive Update in Neurology 0915-162016

64

Clinical applications

bull The o-VEMP is a sensitive test of otolithutricular

function

bull Complements vestibular test procedures that assess

semicircular canals

bull Abnormally robust responses are associated with third

window abnormalities such as semicircular canal

dehiscence

bull Serves as an excellent screening test for semicircular

canal dehiscence

Sixth Annual Intensive Update in Neurology 0915-162016

65

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Sixth Annual Intensive Update in Neurology 0915-162016

66

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Answer 1 References at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

67

Enlarged vestibular aqueduct

bull Axial temporal bone CT showing right temporal bone with enlarged vestibular aqueduct (arrow)

bull Vestibular symptoms accompany progressive sensorineural hearing loss in 4-50 of patients in selected series

Sixth Annual Intensive Update in Neurology 0915-162016

68

Migraine

bull Family or personal history of migraine

bull 25 of migraine patients experience spontaneous vertigo (Baloh 1997)

bull Neuhauser criteria(2001) have been used to construct structured diagnostic interviews (Furman 2003)

bull Not always associated with headache

bull Motion sensitivity

bull Medication responsive

Sixth Annual Intensive Update in Neurology 0915-162016

69

ICHD-III beta Criteria for Vestibular Migraine

bull A At least five attacks fulfilling criteria C and D

bull B A current or past history of 11 migraine without aura or 12 migraine with aura

bull C Vestibular symptoms of moderate or severe intensity lasting between 5 minutes and 72 hours

bull D At least 50 associated with one of the following migrainous features

ndash 1 Headaches

ndash 2 Photophobia and phonophobia

ndash 3 Visual Aura

bull E Not better accounted for by another vestibular disorder

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 28: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

28

Repositioning Maneuvers for Geotropic LSC BPPV

bull Gufoni maneuver

ndash Patient lies quickly onto good side and turns face-down to

floor for two minutes

Sixth Annual Intensive Update in Neurology 0915-162016

29

Left Apogeotropic LSC BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

30

Nystagmus observed During Repositioning

bull Nystagmus should remain in the same torsional

direction as seen on DHT throughout the treatment of

posterior BPPV

bull Reversal of nystagmus direction suggests the particle

has fallen back into the canal and predicts failure

bull In Lateral BPPV nystagmus should beat towards the

good ear

Sixth Annual Intensive Update in Neurology 0915-162016

31

Posterior to Lateral canal conversion

Sixth Annual Intensive Update in Neurology 0915-162016

32

R Posterior to Lateral Canal conversion - geotropic

Sixth Annual Intensive Update in Neurology 0915-162016

33

BPPV Recurrence

bull Recurrence is common (15yr)

bull Otoconial adherence or mineralization demineralization

abnormalities may contribute to recurrence

bull Home canalith repositioning is effective (Radke 2004)

Sixth Annual Intensive Update in Neurology 0915-162016

34

Question 1

bull The most likely semicircular canal to be affected in

BPPV is

ndash 1) superior

ndash 2) lateral

ndash 3) posterior

ndash 4) combined

Sixth Annual Intensive Update in Neurology 0915-162016

35

Question 1

bull The most likely semicircular canal to be affected in

BPPV is

ndash 1) superior

ndash 2) lateral

ndash 3) posterior

ndash 4) combined

Answer 3 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

36

Acute Vestibular Syndrome

bull Rapid unilateral injury to either peripheral or central

vestibular structures produces prolonged vertigo

(days to weeks)

bull Severe vertigo nausea and vomiting spontaneous

nystagmus and postural instability

Sixth Annual Intensive Update in Neurology 0915-162016

37

Acute Vestibular Syndrome

bull 25 of patients with risk factors who present with isolated severe vertigo nystagmus and postural instability in the ER have an acute infarction of the inferior cerebellum (AICA PICA) Central imaging is suggested (Baloh 1998 NEJM)

ndash HTN diabetes smoking age gt65 Afib valvular heart disease occlusive vascular disease

Sixth Annual Intensive Update in Neurology 0915-162016

38

HINTS test

bull Head Impulse

bull Nystagmus

bull Test of Skew

ndash More sensitive than MRI in the diagnosis of acute stroke in

patients with acute vestibular syndrome with at least one risk

factor (Kattah J et al Stroke 2009)

Sixth Annual Intensive Update in Neurology 0915-162016

39

Head Impulse Test

bull No special equipment needed

bull Examiner stands in front of seated patient and

randomly moves head left and right Patient is asked to

focus on examinerrsquos nose

bull Rapid low amplitude thrust from lateral to straight

ahead causes a compensatory saccade when

performed towards the weak side

bull This finding is a permanent feature of unilateral

vestibular loss

Sixth Annual Intensive Update in Neurology 0915-162016

40

Head Impulse Test

Sixth Annual Intensive Update in Neurology 0915-162016

41

Head CT ndash Academy of Emergency Medicine 2013

bull The clinical value of head CT in isolated

dizzinessvertigo without any associated neurological

symptoms is very low

bull Less than 1 of head CTs ordered for dizziness and

vertigo have significant abnormalities and those

patients had severe headache and neurological deficits

in addition to dizziness

bull Forgoing unnecessary emergency head CTs could

save 360 million dollars annually

Sixth Annual Intensive Update in Neurology 0915-162016

42

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Sixth Annual Intensive Update in Neurology 0915-162016

43

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Answer 2 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

44

Acute Vestibular Syndrome

bull Usually peripheral and can be associated with

hearing loss (labyrinthitis)

bull Timely diagnosis improves recovery (ASAP

prednisone 1mgkgday for ten days and taper 10

mgday ndash Strupp M 2004 NEJM)

bull Avoid vestibular suppressants after 3 days and begin

vestibular rehabilitation to hasten compensation

Sixth Annual Intensive Update in Neurology 0915-162016

45

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

46

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Answer 5 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

47

Menierersquos syndrome

bull Fluctuating low frequency hearing loss

bull Tinnitus andor aural fullness

bull Vertigo lasting hours

Sixth Annual Intensive Update in Neurology 0915-162016

48

Normal

Sixth Annual Intensive Update in Neurology 0915-162016

49

Hydrops

Sixth Annual Intensive Update in Neurology 0915-162016

50

Menierersquos syndrome

ndash Diagnosis- Exclusion (RO acoustic)

ndash 23 of Menierersquos patients will improve spontaneously

ndash Treatment-1500 mgday low sodium triamterene375-

hydrochlorothiazide 25 vestibular suppressants (lorazepam

1 mg tablet sublingual Q 8 prn attacks) off label use

Sixth Annual Intensive Update in Neurology 0915-162016

51

Menierersquos syndrome ndash intratympanic steroids

ndash A newer treatment option for those failing medical management

ndash 90 response rate (Boleus-Aguirre MS Otology Neurotology

2008)

ndash Outcomes data confirm excellent clinical response in 3941

Menierersquos patients treated with intratympanic steroids in 2008

Sixth Annual Intensive Update in Neurology 0915-162016

52

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

53

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Answer 5 See references at end

Sixth Annual Intensive Update in Neurology 0915-162016

54

Superior Semicircular Canal Dehiscence (SSCD)

bull Sound andor pressure induced oscillopsia

bull CT reformatted in the plane of the superior canals

shows dehiscence of overlying bone

bull Low frequency ldquoconductive hyperacusisrdquo with elevated

bone thresholds normal reflexes and a conductive loss

Sixth Annual Intensive Update in Neurology 0915-162016

55

SSCD

bull Positive middle ear pressure or loud sound stimulates ampullofugal endolymph flow -canal activation

bull Eye movements are tonic upwards with ipsilateral intorsion

Sixth Annual Intensive Update in Neurology 0915-162016

56

SSCD

bull Valsalva against a closed glottis or jugular compression causes increased intracranial pressure and ampullopetal endolymph flow -canal inhibition

bull Eye movements are tonic downwards with ipsilateral extorsion

Sixth Annual Intensive Update in Neurology 0915-162016

57

Reconstructed left superior semicircular canal

Sixth Annual Intensive Update in Neurology 0915-162016

58

Sixth Annual Intensive Update in Neurology 0915-162016

59

SCHEMATIC DRAWING OF AN OTOLITHIC MACULA

Sixth Annual Intensive Update in Neurology 0915-162016

60

MACULAE OF THE UTRICLESACCULE

Sixth Annual Intensive Update in Neurology 0915-162016

61

HAIR CELLS

Sixth Annual Intensive Update in Neurology 0915-162016

62

SCANNING ELECTRON MICROGRAPH OF OTOCONIA

Sixth Annual Intensive Update in Neurology 0915-162016

63

Ocular VEMP

bull Response to loud clicks (80-110 dB) or forehead tap (Halmagyi and Curthoys 2003)

bull Contralateral oculomotor nucleus (CN III)

bull Inferior oblique muscle contraction (8 msec) detected by 5sec event triggered averaging

bull Noninverting electrode inferior to eye

bull Inverting below non-inverting electrode

bull Ground to forehead

bull Normal subjects have very low response

Sixth Annual Intensive Update in Neurology 0915-162016

64

Clinical applications

bull The o-VEMP is a sensitive test of otolithutricular

function

bull Complements vestibular test procedures that assess

semicircular canals

bull Abnormally robust responses are associated with third

window abnormalities such as semicircular canal

dehiscence

bull Serves as an excellent screening test for semicircular

canal dehiscence

Sixth Annual Intensive Update in Neurology 0915-162016

65

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Sixth Annual Intensive Update in Neurology 0915-162016

66

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Answer 1 References at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

67

Enlarged vestibular aqueduct

bull Axial temporal bone CT showing right temporal bone with enlarged vestibular aqueduct (arrow)

bull Vestibular symptoms accompany progressive sensorineural hearing loss in 4-50 of patients in selected series

Sixth Annual Intensive Update in Neurology 0915-162016

68

Migraine

bull Family or personal history of migraine

bull 25 of migraine patients experience spontaneous vertigo (Baloh 1997)

bull Neuhauser criteria(2001) have been used to construct structured diagnostic interviews (Furman 2003)

bull Not always associated with headache

bull Motion sensitivity

bull Medication responsive

Sixth Annual Intensive Update in Neurology 0915-162016

69

ICHD-III beta Criteria for Vestibular Migraine

bull A At least five attacks fulfilling criteria C and D

bull B A current or past history of 11 migraine without aura or 12 migraine with aura

bull C Vestibular symptoms of moderate or severe intensity lasting between 5 minutes and 72 hours

bull D At least 50 associated with one of the following migrainous features

ndash 1 Headaches

ndash 2 Photophobia and phonophobia

ndash 3 Visual Aura

bull E Not better accounted for by another vestibular disorder

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 29: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

29

Left Apogeotropic LSC BPPV

Sixth Annual Intensive Update in Neurology 0915-162016

30

Nystagmus observed During Repositioning

bull Nystagmus should remain in the same torsional

direction as seen on DHT throughout the treatment of

posterior BPPV

bull Reversal of nystagmus direction suggests the particle

has fallen back into the canal and predicts failure

bull In Lateral BPPV nystagmus should beat towards the

good ear

Sixth Annual Intensive Update in Neurology 0915-162016

31

Posterior to Lateral canal conversion

Sixth Annual Intensive Update in Neurology 0915-162016

32

R Posterior to Lateral Canal conversion - geotropic

Sixth Annual Intensive Update in Neurology 0915-162016

33

BPPV Recurrence

bull Recurrence is common (15yr)

bull Otoconial adherence or mineralization demineralization

abnormalities may contribute to recurrence

bull Home canalith repositioning is effective (Radke 2004)

Sixth Annual Intensive Update in Neurology 0915-162016

34

Question 1

bull The most likely semicircular canal to be affected in

BPPV is

ndash 1) superior

ndash 2) lateral

ndash 3) posterior

ndash 4) combined

Sixth Annual Intensive Update in Neurology 0915-162016

35

Question 1

bull The most likely semicircular canal to be affected in

BPPV is

ndash 1) superior

ndash 2) lateral

ndash 3) posterior

ndash 4) combined

Answer 3 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

36

Acute Vestibular Syndrome

bull Rapid unilateral injury to either peripheral or central

vestibular structures produces prolonged vertigo

(days to weeks)

bull Severe vertigo nausea and vomiting spontaneous

nystagmus and postural instability

Sixth Annual Intensive Update in Neurology 0915-162016

37

Acute Vestibular Syndrome

bull 25 of patients with risk factors who present with isolated severe vertigo nystagmus and postural instability in the ER have an acute infarction of the inferior cerebellum (AICA PICA) Central imaging is suggested (Baloh 1998 NEJM)

ndash HTN diabetes smoking age gt65 Afib valvular heart disease occlusive vascular disease

Sixth Annual Intensive Update in Neurology 0915-162016

38

HINTS test

bull Head Impulse

bull Nystagmus

bull Test of Skew

ndash More sensitive than MRI in the diagnosis of acute stroke in

patients with acute vestibular syndrome with at least one risk

factor (Kattah J et al Stroke 2009)

Sixth Annual Intensive Update in Neurology 0915-162016

39

Head Impulse Test

bull No special equipment needed

bull Examiner stands in front of seated patient and

randomly moves head left and right Patient is asked to

focus on examinerrsquos nose

bull Rapid low amplitude thrust from lateral to straight

ahead causes a compensatory saccade when

performed towards the weak side

bull This finding is a permanent feature of unilateral

vestibular loss

Sixth Annual Intensive Update in Neurology 0915-162016

40

Head Impulse Test

Sixth Annual Intensive Update in Neurology 0915-162016

41

Head CT ndash Academy of Emergency Medicine 2013

bull The clinical value of head CT in isolated

dizzinessvertigo without any associated neurological

symptoms is very low

bull Less than 1 of head CTs ordered for dizziness and

vertigo have significant abnormalities and those

patients had severe headache and neurological deficits

in addition to dizziness

bull Forgoing unnecessary emergency head CTs could

save 360 million dollars annually

Sixth Annual Intensive Update in Neurology 0915-162016

42

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Sixth Annual Intensive Update in Neurology 0915-162016

43

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Answer 2 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

44

Acute Vestibular Syndrome

bull Usually peripheral and can be associated with

hearing loss (labyrinthitis)

bull Timely diagnosis improves recovery (ASAP

prednisone 1mgkgday for ten days and taper 10

mgday ndash Strupp M 2004 NEJM)

bull Avoid vestibular suppressants after 3 days and begin

vestibular rehabilitation to hasten compensation

Sixth Annual Intensive Update in Neurology 0915-162016

45

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

46

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Answer 5 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

47

Menierersquos syndrome

bull Fluctuating low frequency hearing loss

bull Tinnitus andor aural fullness

bull Vertigo lasting hours

Sixth Annual Intensive Update in Neurology 0915-162016

48

Normal

Sixth Annual Intensive Update in Neurology 0915-162016

49

Hydrops

Sixth Annual Intensive Update in Neurology 0915-162016

50

Menierersquos syndrome

ndash Diagnosis- Exclusion (RO acoustic)

ndash 23 of Menierersquos patients will improve spontaneously

ndash Treatment-1500 mgday low sodium triamterene375-

hydrochlorothiazide 25 vestibular suppressants (lorazepam

1 mg tablet sublingual Q 8 prn attacks) off label use

Sixth Annual Intensive Update in Neurology 0915-162016

51

Menierersquos syndrome ndash intratympanic steroids

ndash A newer treatment option for those failing medical management

ndash 90 response rate (Boleus-Aguirre MS Otology Neurotology

2008)

ndash Outcomes data confirm excellent clinical response in 3941

Menierersquos patients treated with intratympanic steroids in 2008

Sixth Annual Intensive Update in Neurology 0915-162016

52

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

53

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Answer 5 See references at end

Sixth Annual Intensive Update in Neurology 0915-162016

54

Superior Semicircular Canal Dehiscence (SSCD)

bull Sound andor pressure induced oscillopsia

bull CT reformatted in the plane of the superior canals

shows dehiscence of overlying bone

bull Low frequency ldquoconductive hyperacusisrdquo with elevated

bone thresholds normal reflexes and a conductive loss

Sixth Annual Intensive Update in Neurology 0915-162016

55

SSCD

bull Positive middle ear pressure or loud sound stimulates ampullofugal endolymph flow -canal activation

bull Eye movements are tonic upwards with ipsilateral intorsion

Sixth Annual Intensive Update in Neurology 0915-162016

56

SSCD

bull Valsalva against a closed glottis or jugular compression causes increased intracranial pressure and ampullopetal endolymph flow -canal inhibition

bull Eye movements are tonic downwards with ipsilateral extorsion

Sixth Annual Intensive Update in Neurology 0915-162016

57

Reconstructed left superior semicircular canal

Sixth Annual Intensive Update in Neurology 0915-162016

58

Sixth Annual Intensive Update in Neurology 0915-162016

59

SCHEMATIC DRAWING OF AN OTOLITHIC MACULA

Sixth Annual Intensive Update in Neurology 0915-162016

60

MACULAE OF THE UTRICLESACCULE

Sixth Annual Intensive Update in Neurology 0915-162016

61

HAIR CELLS

Sixth Annual Intensive Update in Neurology 0915-162016

62

SCANNING ELECTRON MICROGRAPH OF OTOCONIA

Sixth Annual Intensive Update in Neurology 0915-162016

63

Ocular VEMP

bull Response to loud clicks (80-110 dB) or forehead tap (Halmagyi and Curthoys 2003)

bull Contralateral oculomotor nucleus (CN III)

bull Inferior oblique muscle contraction (8 msec) detected by 5sec event triggered averaging

bull Noninverting electrode inferior to eye

bull Inverting below non-inverting electrode

bull Ground to forehead

bull Normal subjects have very low response

Sixth Annual Intensive Update in Neurology 0915-162016

64

Clinical applications

bull The o-VEMP is a sensitive test of otolithutricular

function

bull Complements vestibular test procedures that assess

semicircular canals

bull Abnormally robust responses are associated with third

window abnormalities such as semicircular canal

dehiscence

bull Serves as an excellent screening test for semicircular

canal dehiscence

Sixth Annual Intensive Update in Neurology 0915-162016

65

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Sixth Annual Intensive Update in Neurology 0915-162016

66

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Answer 1 References at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

67

Enlarged vestibular aqueduct

bull Axial temporal bone CT showing right temporal bone with enlarged vestibular aqueduct (arrow)

bull Vestibular symptoms accompany progressive sensorineural hearing loss in 4-50 of patients in selected series

Sixth Annual Intensive Update in Neurology 0915-162016

68

Migraine

bull Family or personal history of migraine

bull 25 of migraine patients experience spontaneous vertigo (Baloh 1997)

bull Neuhauser criteria(2001) have been used to construct structured diagnostic interviews (Furman 2003)

bull Not always associated with headache

bull Motion sensitivity

bull Medication responsive

Sixth Annual Intensive Update in Neurology 0915-162016

69

ICHD-III beta Criteria for Vestibular Migraine

bull A At least five attacks fulfilling criteria C and D

bull B A current or past history of 11 migraine without aura or 12 migraine with aura

bull C Vestibular symptoms of moderate or severe intensity lasting between 5 minutes and 72 hours

bull D At least 50 associated with one of the following migrainous features

ndash 1 Headaches

ndash 2 Photophobia and phonophobia

ndash 3 Visual Aura

bull E Not better accounted for by another vestibular disorder

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 30: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

30

Nystagmus observed During Repositioning

bull Nystagmus should remain in the same torsional

direction as seen on DHT throughout the treatment of

posterior BPPV

bull Reversal of nystagmus direction suggests the particle

has fallen back into the canal and predicts failure

bull In Lateral BPPV nystagmus should beat towards the

good ear

Sixth Annual Intensive Update in Neurology 0915-162016

31

Posterior to Lateral canal conversion

Sixth Annual Intensive Update in Neurology 0915-162016

32

R Posterior to Lateral Canal conversion - geotropic

Sixth Annual Intensive Update in Neurology 0915-162016

33

BPPV Recurrence

bull Recurrence is common (15yr)

bull Otoconial adherence or mineralization demineralization

abnormalities may contribute to recurrence

bull Home canalith repositioning is effective (Radke 2004)

Sixth Annual Intensive Update in Neurology 0915-162016

34

Question 1

bull The most likely semicircular canal to be affected in

BPPV is

ndash 1) superior

ndash 2) lateral

ndash 3) posterior

ndash 4) combined

Sixth Annual Intensive Update in Neurology 0915-162016

35

Question 1

bull The most likely semicircular canal to be affected in

BPPV is

ndash 1) superior

ndash 2) lateral

ndash 3) posterior

ndash 4) combined

Answer 3 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

36

Acute Vestibular Syndrome

bull Rapid unilateral injury to either peripheral or central

vestibular structures produces prolonged vertigo

(days to weeks)

bull Severe vertigo nausea and vomiting spontaneous

nystagmus and postural instability

Sixth Annual Intensive Update in Neurology 0915-162016

37

Acute Vestibular Syndrome

bull 25 of patients with risk factors who present with isolated severe vertigo nystagmus and postural instability in the ER have an acute infarction of the inferior cerebellum (AICA PICA) Central imaging is suggested (Baloh 1998 NEJM)

ndash HTN diabetes smoking age gt65 Afib valvular heart disease occlusive vascular disease

Sixth Annual Intensive Update in Neurology 0915-162016

38

HINTS test

bull Head Impulse

bull Nystagmus

bull Test of Skew

ndash More sensitive than MRI in the diagnosis of acute stroke in

patients with acute vestibular syndrome with at least one risk

factor (Kattah J et al Stroke 2009)

Sixth Annual Intensive Update in Neurology 0915-162016

39

Head Impulse Test

bull No special equipment needed

bull Examiner stands in front of seated patient and

randomly moves head left and right Patient is asked to

focus on examinerrsquos nose

bull Rapid low amplitude thrust from lateral to straight

ahead causes a compensatory saccade when

performed towards the weak side

bull This finding is a permanent feature of unilateral

vestibular loss

Sixth Annual Intensive Update in Neurology 0915-162016

40

Head Impulse Test

Sixth Annual Intensive Update in Neurology 0915-162016

41

Head CT ndash Academy of Emergency Medicine 2013

bull The clinical value of head CT in isolated

dizzinessvertigo without any associated neurological

symptoms is very low

bull Less than 1 of head CTs ordered for dizziness and

vertigo have significant abnormalities and those

patients had severe headache and neurological deficits

in addition to dizziness

bull Forgoing unnecessary emergency head CTs could

save 360 million dollars annually

Sixth Annual Intensive Update in Neurology 0915-162016

42

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Sixth Annual Intensive Update in Neurology 0915-162016

43

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Answer 2 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

44

Acute Vestibular Syndrome

bull Usually peripheral and can be associated with

hearing loss (labyrinthitis)

bull Timely diagnosis improves recovery (ASAP

prednisone 1mgkgday for ten days and taper 10

mgday ndash Strupp M 2004 NEJM)

bull Avoid vestibular suppressants after 3 days and begin

vestibular rehabilitation to hasten compensation

Sixth Annual Intensive Update in Neurology 0915-162016

45

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

46

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Answer 5 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

47

Menierersquos syndrome

bull Fluctuating low frequency hearing loss

bull Tinnitus andor aural fullness

bull Vertigo lasting hours

Sixth Annual Intensive Update in Neurology 0915-162016

48

Normal

Sixth Annual Intensive Update in Neurology 0915-162016

49

Hydrops

Sixth Annual Intensive Update in Neurology 0915-162016

50

Menierersquos syndrome

ndash Diagnosis- Exclusion (RO acoustic)

ndash 23 of Menierersquos patients will improve spontaneously

ndash Treatment-1500 mgday low sodium triamterene375-

hydrochlorothiazide 25 vestibular suppressants (lorazepam

1 mg tablet sublingual Q 8 prn attacks) off label use

Sixth Annual Intensive Update in Neurology 0915-162016

51

Menierersquos syndrome ndash intratympanic steroids

ndash A newer treatment option for those failing medical management

ndash 90 response rate (Boleus-Aguirre MS Otology Neurotology

2008)

ndash Outcomes data confirm excellent clinical response in 3941

Menierersquos patients treated with intratympanic steroids in 2008

Sixth Annual Intensive Update in Neurology 0915-162016

52

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

53

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Answer 5 See references at end

Sixth Annual Intensive Update in Neurology 0915-162016

54

Superior Semicircular Canal Dehiscence (SSCD)

bull Sound andor pressure induced oscillopsia

bull CT reformatted in the plane of the superior canals

shows dehiscence of overlying bone

bull Low frequency ldquoconductive hyperacusisrdquo with elevated

bone thresholds normal reflexes and a conductive loss

Sixth Annual Intensive Update in Neurology 0915-162016

55

SSCD

bull Positive middle ear pressure or loud sound stimulates ampullofugal endolymph flow -canal activation

bull Eye movements are tonic upwards with ipsilateral intorsion

Sixth Annual Intensive Update in Neurology 0915-162016

56

SSCD

bull Valsalva against a closed glottis or jugular compression causes increased intracranial pressure and ampullopetal endolymph flow -canal inhibition

bull Eye movements are tonic downwards with ipsilateral extorsion

Sixth Annual Intensive Update in Neurology 0915-162016

57

Reconstructed left superior semicircular canal

Sixth Annual Intensive Update in Neurology 0915-162016

58

Sixth Annual Intensive Update in Neurology 0915-162016

59

SCHEMATIC DRAWING OF AN OTOLITHIC MACULA

Sixth Annual Intensive Update in Neurology 0915-162016

60

MACULAE OF THE UTRICLESACCULE

Sixth Annual Intensive Update in Neurology 0915-162016

61

HAIR CELLS

Sixth Annual Intensive Update in Neurology 0915-162016

62

SCANNING ELECTRON MICROGRAPH OF OTOCONIA

Sixth Annual Intensive Update in Neurology 0915-162016

63

Ocular VEMP

bull Response to loud clicks (80-110 dB) or forehead tap (Halmagyi and Curthoys 2003)

bull Contralateral oculomotor nucleus (CN III)

bull Inferior oblique muscle contraction (8 msec) detected by 5sec event triggered averaging

bull Noninverting electrode inferior to eye

bull Inverting below non-inverting electrode

bull Ground to forehead

bull Normal subjects have very low response

Sixth Annual Intensive Update in Neurology 0915-162016

64

Clinical applications

bull The o-VEMP is a sensitive test of otolithutricular

function

bull Complements vestibular test procedures that assess

semicircular canals

bull Abnormally robust responses are associated with third

window abnormalities such as semicircular canal

dehiscence

bull Serves as an excellent screening test for semicircular

canal dehiscence

Sixth Annual Intensive Update in Neurology 0915-162016

65

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Sixth Annual Intensive Update in Neurology 0915-162016

66

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Answer 1 References at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

67

Enlarged vestibular aqueduct

bull Axial temporal bone CT showing right temporal bone with enlarged vestibular aqueduct (arrow)

bull Vestibular symptoms accompany progressive sensorineural hearing loss in 4-50 of patients in selected series

Sixth Annual Intensive Update in Neurology 0915-162016

68

Migraine

bull Family or personal history of migraine

bull 25 of migraine patients experience spontaneous vertigo (Baloh 1997)

bull Neuhauser criteria(2001) have been used to construct structured diagnostic interviews (Furman 2003)

bull Not always associated with headache

bull Motion sensitivity

bull Medication responsive

Sixth Annual Intensive Update in Neurology 0915-162016

69

ICHD-III beta Criteria for Vestibular Migraine

bull A At least five attacks fulfilling criteria C and D

bull B A current or past history of 11 migraine without aura or 12 migraine with aura

bull C Vestibular symptoms of moderate or severe intensity lasting between 5 minutes and 72 hours

bull D At least 50 associated with one of the following migrainous features

ndash 1 Headaches

ndash 2 Photophobia and phonophobia

ndash 3 Visual Aura

bull E Not better accounted for by another vestibular disorder

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 31: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

31

Posterior to Lateral canal conversion

Sixth Annual Intensive Update in Neurology 0915-162016

32

R Posterior to Lateral Canal conversion - geotropic

Sixth Annual Intensive Update in Neurology 0915-162016

33

BPPV Recurrence

bull Recurrence is common (15yr)

bull Otoconial adherence or mineralization demineralization

abnormalities may contribute to recurrence

bull Home canalith repositioning is effective (Radke 2004)

Sixth Annual Intensive Update in Neurology 0915-162016

34

Question 1

bull The most likely semicircular canal to be affected in

BPPV is

ndash 1) superior

ndash 2) lateral

ndash 3) posterior

ndash 4) combined

Sixth Annual Intensive Update in Neurology 0915-162016

35

Question 1

bull The most likely semicircular canal to be affected in

BPPV is

ndash 1) superior

ndash 2) lateral

ndash 3) posterior

ndash 4) combined

Answer 3 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

36

Acute Vestibular Syndrome

bull Rapid unilateral injury to either peripheral or central

vestibular structures produces prolonged vertigo

(days to weeks)

bull Severe vertigo nausea and vomiting spontaneous

nystagmus and postural instability

Sixth Annual Intensive Update in Neurology 0915-162016

37

Acute Vestibular Syndrome

bull 25 of patients with risk factors who present with isolated severe vertigo nystagmus and postural instability in the ER have an acute infarction of the inferior cerebellum (AICA PICA) Central imaging is suggested (Baloh 1998 NEJM)

ndash HTN diabetes smoking age gt65 Afib valvular heart disease occlusive vascular disease

Sixth Annual Intensive Update in Neurology 0915-162016

38

HINTS test

bull Head Impulse

bull Nystagmus

bull Test of Skew

ndash More sensitive than MRI in the diagnosis of acute stroke in

patients with acute vestibular syndrome with at least one risk

factor (Kattah J et al Stroke 2009)

Sixth Annual Intensive Update in Neurology 0915-162016

39

Head Impulse Test

bull No special equipment needed

bull Examiner stands in front of seated patient and

randomly moves head left and right Patient is asked to

focus on examinerrsquos nose

bull Rapid low amplitude thrust from lateral to straight

ahead causes a compensatory saccade when

performed towards the weak side

bull This finding is a permanent feature of unilateral

vestibular loss

Sixth Annual Intensive Update in Neurology 0915-162016

40

Head Impulse Test

Sixth Annual Intensive Update in Neurology 0915-162016

41

Head CT ndash Academy of Emergency Medicine 2013

bull The clinical value of head CT in isolated

dizzinessvertigo without any associated neurological

symptoms is very low

bull Less than 1 of head CTs ordered for dizziness and

vertigo have significant abnormalities and those

patients had severe headache and neurological deficits

in addition to dizziness

bull Forgoing unnecessary emergency head CTs could

save 360 million dollars annually

Sixth Annual Intensive Update in Neurology 0915-162016

42

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Sixth Annual Intensive Update in Neurology 0915-162016

43

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Answer 2 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

44

Acute Vestibular Syndrome

bull Usually peripheral and can be associated with

hearing loss (labyrinthitis)

bull Timely diagnosis improves recovery (ASAP

prednisone 1mgkgday for ten days and taper 10

mgday ndash Strupp M 2004 NEJM)

bull Avoid vestibular suppressants after 3 days and begin

vestibular rehabilitation to hasten compensation

Sixth Annual Intensive Update in Neurology 0915-162016

45

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

46

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Answer 5 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

47

Menierersquos syndrome

bull Fluctuating low frequency hearing loss

bull Tinnitus andor aural fullness

bull Vertigo lasting hours

Sixth Annual Intensive Update in Neurology 0915-162016

48

Normal

Sixth Annual Intensive Update in Neurology 0915-162016

49

Hydrops

Sixth Annual Intensive Update in Neurology 0915-162016

50

Menierersquos syndrome

ndash Diagnosis- Exclusion (RO acoustic)

ndash 23 of Menierersquos patients will improve spontaneously

ndash Treatment-1500 mgday low sodium triamterene375-

hydrochlorothiazide 25 vestibular suppressants (lorazepam

1 mg tablet sublingual Q 8 prn attacks) off label use

Sixth Annual Intensive Update in Neurology 0915-162016

51

Menierersquos syndrome ndash intratympanic steroids

ndash A newer treatment option for those failing medical management

ndash 90 response rate (Boleus-Aguirre MS Otology Neurotology

2008)

ndash Outcomes data confirm excellent clinical response in 3941

Menierersquos patients treated with intratympanic steroids in 2008

Sixth Annual Intensive Update in Neurology 0915-162016

52

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

53

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Answer 5 See references at end

Sixth Annual Intensive Update in Neurology 0915-162016

54

Superior Semicircular Canal Dehiscence (SSCD)

bull Sound andor pressure induced oscillopsia

bull CT reformatted in the plane of the superior canals

shows dehiscence of overlying bone

bull Low frequency ldquoconductive hyperacusisrdquo with elevated

bone thresholds normal reflexes and a conductive loss

Sixth Annual Intensive Update in Neurology 0915-162016

55

SSCD

bull Positive middle ear pressure or loud sound stimulates ampullofugal endolymph flow -canal activation

bull Eye movements are tonic upwards with ipsilateral intorsion

Sixth Annual Intensive Update in Neurology 0915-162016

56

SSCD

bull Valsalva against a closed glottis or jugular compression causes increased intracranial pressure and ampullopetal endolymph flow -canal inhibition

bull Eye movements are tonic downwards with ipsilateral extorsion

Sixth Annual Intensive Update in Neurology 0915-162016

57

Reconstructed left superior semicircular canal

Sixth Annual Intensive Update in Neurology 0915-162016

58

Sixth Annual Intensive Update in Neurology 0915-162016

59

SCHEMATIC DRAWING OF AN OTOLITHIC MACULA

Sixth Annual Intensive Update in Neurology 0915-162016

60

MACULAE OF THE UTRICLESACCULE

Sixth Annual Intensive Update in Neurology 0915-162016

61

HAIR CELLS

Sixth Annual Intensive Update in Neurology 0915-162016

62

SCANNING ELECTRON MICROGRAPH OF OTOCONIA

Sixth Annual Intensive Update in Neurology 0915-162016

63

Ocular VEMP

bull Response to loud clicks (80-110 dB) or forehead tap (Halmagyi and Curthoys 2003)

bull Contralateral oculomotor nucleus (CN III)

bull Inferior oblique muscle contraction (8 msec) detected by 5sec event triggered averaging

bull Noninverting electrode inferior to eye

bull Inverting below non-inverting electrode

bull Ground to forehead

bull Normal subjects have very low response

Sixth Annual Intensive Update in Neurology 0915-162016

64

Clinical applications

bull The o-VEMP is a sensitive test of otolithutricular

function

bull Complements vestibular test procedures that assess

semicircular canals

bull Abnormally robust responses are associated with third

window abnormalities such as semicircular canal

dehiscence

bull Serves as an excellent screening test for semicircular

canal dehiscence

Sixth Annual Intensive Update in Neurology 0915-162016

65

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Sixth Annual Intensive Update in Neurology 0915-162016

66

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Answer 1 References at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

67

Enlarged vestibular aqueduct

bull Axial temporal bone CT showing right temporal bone with enlarged vestibular aqueduct (arrow)

bull Vestibular symptoms accompany progressive sensorineural hearing loss in 4-50 of patients in selected series

Sixth Annual Intensive Update in Neurology 0915-162016

68

Migraine

bull Family or personal history of migraine

bull 25 of migraine patients experience spontaneous vertigo (Baloh 1997)

bull Neuhauser criteria(2001) have been used to construct structured diagnostic interviews (Furman 2003)

bull Not always associated with headache

bull Motion sensitivity

bull Medication responsive

Sixth Annual Intensive Update in Neurology 0915-162016

69

ICHD-III beta Criteria for Vestibular Migraine

bull A At least five attacks fulfilling criteria C and D

bull B A current or past history of 11 migraine without aura or 12 migraine with aura

bull C Vestibular symptoms of moderate or severe intensity lasting between 5 minutes and 72 hours

bull D At least 50 associated with one of the following migrainous features

ndash 1 Headaches

ndash 2 Photophobia and phonophobia

ndash 3 Visual Aura

bull E Not better accounted for by another vestibular disorder

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 32: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

32

R Posterior to Lateral Canal conversion - geotropic

Sixth Annual Intensive Update in Neurology 0915-162016

33

BPPV Recurrence

bull Recurrence is common (15yr)

bull Otoconial adherence or mineralization demineralization

abnormalities may contribute to recurrence

bull Home canalith repositioning is effective (Radke 2004)

Sixth Annual Intensive Update in Neurology 0915-162016

34

Question 1

bull The most likely semicircular canal to be affected in

BPPV is

ndash 1) superior

ndash 2) lateral

ndash 3) posterior

ndash 4) combined

Sixth Annual Intensive Update in Neurology 0915-162016

35

Question 1

bull The most likely semicircular canal to be affected in

BPPV is

ndash 1) superior

ndash 2) lateral

ndash 3) posterior

ndash 4) combined

Answer 3 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

36

Acute Vestibular Syndrome

bull Rapid unilateral injury to either peripheral or central

vestibular structures produces prolonged vertigo

(days to weeks)

bull Severe vertigo nausea and vomiting spontaneous

nystagmus and postural instability

Sixth Annual Intensive Update in Neurology 0915-162016

37

Acute Vestibular Syndrome

bull 25 of patients with risk factors who present with isolated severe vertigo nystagmus and postural instability in the ER have an acute infarction of the inferior cerebellum (AICA PICA) Central imaging is suggested (Baloh 1998 NEJM)

ndash HTN diabetes smoking age gt65 Afib valvular heart disease occlusive vascular disease

Sixth Annual Intensive Update in Neurology 0915-162016

38

HINTS test

bull Head Impulse

bull Nystagmus

bull Test of Skew

ndash More sensitive than MRI in the diagnosis of acute stroke in

patients with acute vestibular syndrome with at least one risk

factor (Kattah J et al Stroke 2009)

Sixth Annual Intensive Update in Neurology 0915-162016

39

Head Impulse Test

bull No special equipment needed

bull Examiner stands in front of seated patient and

randomly moves head left and right Patient is asked to

focus on examinerrsquos nose

bull Rapid low amplitude thrust from lateral to straight

ahead causes a compensatory saccade when

performed towards the weak side

bull This finding is a permanent feature of unilateral

vestibular loss

Sixth Annual Intensive Update in Neurology 0915-162016

40

Head Impulse Test

Sixth Annual Intensive Update in Neurology 0915-162016

41

Head CT ndash Academy of Emergency Medicine 2013

bull The clinical value of head CT in isolated

dizzinessvertigo without any associated neurological

symptoms is very low

bull Less than 1 of head CTs ordered for dizziness and

vertigo have significant abnormalities and those

patients had severe headache and neurological deficits

in addition to dizziness

bull Forgoing unnecessary emergency head CTs could

save 360 million dollars annually

Sixth Annual Intensive Update in Neurology 0915-162016

42

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Sixth Annual Intensive Update in Neurology 0915-162016

43

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Answer 2 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

44

Acute Vestibular Syndrome

bull Usually peripheral and can be associated with

hearing loss (labyrinthitis)

bull Timely diagnosis improves recovery (ASAP

prednisone 1mgkgday for ten days and taper 10

mgday ndash Strupp M 2004 NEJM)

bull Avoid vestibular suppressants after 3 days and begin

vestibular rehabilitation to hasten compensation

Sixth Annual Intensive Update in Neurology 0915-162016

45

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

46

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Answer 5 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

47

Menierersquos syndrome

bull Fluctuating low frequency hearing loss

bull Tinnitus andor aural fullness

bull Vertigo lasting hours

Sixth Annual Intensive Update in Neurology 0915-162016

48

Normal

Sixth Annual Intensive Update in Neurology 0915-162016

49

Hydrops

Sixth Annual Intensive Update in Neurology 0915-162016

50

Menierersquos syndrome

ndash Diagnosis- Exclusion (RO acoustic)

ndash 23 of Menierersquos patients will improve spontaneously

ndash Treatment-1500 mgday low sodium triamterene375-

hydrochlorothiazide 25 vestibular suppressants (lorazepam

1 mg tablet sublingual Q 8 prn attacks) off label use

Sixth Annual Intensive Update in Neurology 0915-162016

51

Menierersquos syndrome ndash intratympanic steroids

ndash A newer treatment option for those failing medical management

ndash 90 response rate (Boleus-Aguirre MS Otology Neurotology

2008)

ndash Outcomes data confirm excellent clinical response in 3941

Menierersquos patients treated with intratympanic steroids in 2008

Sixth Annual Intensive Update in Neurology 0915-162016

52

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

53

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Answer 5 See references at end

Sixth Annual Intensive Update in Neurology 0915-162016

54

Superior Semicircular Canal Dehiscence (SSCD)

bull Sound andor pressure induced oscillopsia

bull CT reformatted in the plane of the superior canals

shows dehiscence of overlying bone

bull Low frequency ldquoconductive hyperacusisrdquo with elevated

bone thresholds normal reflexes and a conductive loss

Sixth Annual Intensive Update in Neurology 0915-162016

55

SSCD

bull Positive middle ear pressure or loud sound stimulates ampullofugal endolymph flow -canal activation

bull Eye movements are tonic upwards with ipsilateral intorsion

Sixth Annual Intensive Update in Neurology 0915-162016

56

SSCD

bull Valsalva against a closed glottis or jugular compression causes increased intracranial pressure and ampullopetal endolymph flow -canal inhibition

bull Eye movements are tonic downwards with ipsilateral extorsion

Sixth Annual Intensive Update in Neurology 0915-162016

57

Reconstructed left superior semicircular canal

Sixth Annual Intensive Update in Neurology 0915-162016

58

Sixth Annual Intensive Update in Neurology 0915-162016

59

SCHEMATIC DRAWING OF AN OTOLITHIC MACULA

Sixth Annual Intensive Update in Neurology 0915-162016

60

MACULAE OF THE UTRICLESACCULE

Sixth Annual Intensive Update in Neurology 0915-162016

61

HAIR CELLS

Sixth Annual Intensive Update in Neurology 0915-162016

62

SCANNING ELECTRON MICROGRAPH OF OTOCONIA

Sixth Annual Intensive Update in Neurology 0915-162016

63

Ocular VEMP

bull Response to loud clicks (80-110 dB) or forehead tap (Halmagyi and Curthoys 2003)

bull Contralateral oculomotor nucleus (CN III)

bull Inferior oblique muscle contraction (8 msec) detected by 5sec event triggered averaging

bull Noninverting electrode inferior to eye

bull Inverting below non-inverting electrode

bull Ground to forehead

bull Normal subjects have very low response

Sixth Annual Intensive Update in Neurology 0915-162016

64

Clinical applications

bull The o-VEMP is a sensitive test of otolithutricular

function

bull Complements vestibular test procedures that assess

semicircular canals

bull Abnormally robust responses are associated with third

window abnormalities such as semicircular canal

dehiscence

bull Serves as an excellent screening test for semicircular

canal dehiscence

Sixth Annual Intensive Update in Neurology 0915-162016

65

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Sixth Annual Intensive Update in Neurology 0915-162016

66

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Answer 1 References at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

67

Enlarged vestibular aqueduct

bull Axial temporal bone CT showing right temporal bone with enlarged vestibular aqueduct (arrow)

bull Vestibular symptoms accompany progressive sensorineural hearing loss in 4-50 of patients in selected series

Sixth Annual Intensive Update in Neurology 0915-162016

68

Migraine

bull Family or personal history of migraine

bull 25 of migraine patients experience spontaneous vertigo (Baloh 1997)

bull Neuhauser criteria(2001) have been used to construct structured diagnostic interviews (Furman 2003)

bull Not always associated with headache

bull Motion sensitivity

bull Medication responsive

Sixth Annual Intensive Update in Neurology 0915-162016

69

ICHD-III beta Criteria for Vestibular Migraine

bull A At least five attacks fulfilling criteria C and D

bull B A current or past history of 11 migraine without aura or 12 migraine with aura

bull C Vestibular symptoms of moderate or severe intensity lasting between 5 minutes and 72 hours

bull D At least 50 associated with one of the following migrainous features

ndash 1 Headaches

ndash 2 Photophobia and phonophobia

ndash 3 Visual Aura

bull E Not better accounted for by another vestibular disorder

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 33: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

33

BPPV Recurrence

bull Recurrence is common (15yr)

bull Otoconial adherence or mineralization demineralization

abnormalities may contribute to recurrence

bull Home canalith repositioning is effective (Radke 2004)

Sixth Annual Intensive Update in Neurology 0915-162016

34

Question 1

bull The most likely semicircular canal to be affected in

BPPV is

ndash 1) superior

ndash 2) lateral

ndash 3) posterior

ndash 4) combined

Sixth Annual Intensive Update in Neurology 0915-162016

35

Question 1

bull The most likely semicircular canal to be affected in

BPPV is

ndash 1) superior

ndash 2) lateral

ndash 3) posterior

ndash 4) combined

Answer 3 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

36

Acute Vestibular Syndrome

bull Rapid unilateral injury to either peripheral or central

vestibular structures produces prolonged vertigo

(days to weeks)

bull Severe vertigo nausea and vomiting spontaneous

nystagmus and postural instability

Sixth Annual Intensive Update in Neurology 0915-162016

37

Acute Vestibular Syndrome

bull 25 of patients with risk factors who present with isolated severe vertigo nystagmus and postural instability in the ER have an acute infarction of the inferior cerebellum (AICA PICA) Central imaging is suggested (Baloh 1998 NEJM)

ndash HTN diabetes smoking age gt65 Afib valvular heart disease occlusive vascular disease

Sixth Annual Intensive Update in Neurology 0915-162016

38

HINTS test

bull Head Impulse

bull Nystagmus

bull Test of Skew

ndash More sensitive than MRI in the diagnosis of acute stroke in

patients with acute vestibular syndrome with at least one risk

factor (Kattah J et al Stroke 2009)

Sixth Annual Intensive Update in Neurology 0915-162016

39

Head Impulse Test

bull No special equipment needed

bull Examiner stands in front of seated patient and

randomly moves head left and right Patient is asked to

focus on examinerrsquos nose

bull Rapid low amplitude thrust from lateral to straight

ahead causes a compensatory saccade when

performed towards the weak side

bull This finding is a permanent feature of unilateral

vestibular loss

Sixth Annual Intensive Update in Neurology 0915-162016

40

Head Impulse Test

Sixth Annual Intensive Update in Neurology 0915-162016

41

Head CT ndash Academy of Emergency Medicine 2013

bull The clinical value of head CT in isolated

dizzinessvertigo without any associated neurological

symptoms is very low

bull Less than 1 of head CTs ordered for dizziness and

vertigo have significant abnormalities and those

patients had severe headache and neurological deficits

in addition to dizziness

bull Forgoing unnecessary emergency head CTs could

save 360 million dollars annually

Sixth Annual Intensive Update in Neurology 0915-162016

42

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Sixth Annual Intensive Update in Neurology 0915-162016

43

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Answer 2 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

44

Acute Vestibular Syndrome

bull Usually peripheral and can be associated with

hearing loss (labyrinthitis)

bull Timely diagnosis improves recovery (ASAP

prednisone 1mgkgday for ten days and taper 10

mgday ndash Strupp M 2004 NEJM)

bull Avoid vestibular suppressants after 3 days and begin

vestibular rehabilitation to hasten compensation

Sixth Annual Intensive Update in Neurology 0915-162016

45

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

46

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Answer 5 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

47

Menierersquos syndrome

bull Fluctuating low frequency hearing loss

bull Tinnitus andor aural fullness

bull Vertigo lasting hours

Sixth Annual Intensive Update in Neurology 0915-162016

48

Normal

Sixth Annual Intensive Update in Neurology 0915-162016

49

Hydrops

Sixth Annual Intensive Update in Neurology 0915-162016

50

Menierersquos syndrome

ndash Diagnosis- Exclusion (RO acoustic)

ndash 23 of Menierersquos patients will improve spontaneously

ndash Treatment-1500 mgday low sodium triamterene375-

hydrochlorothiazide 25 vestibular suppressants (lorazepam

1 mg tablet sublingual Q 8 prn attacks) off label use

Sixth Annual Intensive Update in Neurology 0915-162016

51

Menierersquos syndrome ndash intratympanic steroids

ndash A newer treatment option for those failing medical management

ndash 90 response rate (Boleus-Aguirre MS Otology Neurotology

2008)

ndash Outcomes data confirm excellent clinical response in 3941

Menierersquos patients treated with intratympanic steroids in 2008

Sixth Annual Intensive Update in Neurology 0915-162016

52

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

53

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Answer 5 See references at end

Sixth Annual Intensive Update in Neurology 0915-162016

54

Superior Semicircular Canal Dehiscence (SSCD)

bull Sound andor pressure induced oscillopsia

bull CT reformatted in the plane of the superior canals

shows dehiscence of overlying bone

bull Low frequency ldquoconductive hyperacusisrdquo with elevated

bone thresholds normal reflexes and a conductive loss

Sixth Annual Intensive Update in Neurology 0915-162016

55

SSCD

bull Positive middle ear pressure or loud sound stimulates ampullofugal endolymph flow -canal activation

bull Eye movements are tonic upwards with ipsilateral intorsion

Sixth Annual Intensive Update in Neurology 0915-162016

56

SSCD

bull Valsalva against a closed glottis or jugular compression causes increased intracranial pressure and ampullopetal endolymph flow -canal inhibition

bull Eye movements are tonic downwards with ipsilateral extorsion

Sixth Annual Intensive Update in Neurology 0915-162016

57

Reconstructed left superior semicircular canal

Sixth Annual Intensive Update in Neurology 0915-162016

58

Sixth Annual Intensive Update in Neurology 0915-162016

59

SCHEMATIC DRAWING OF AN OTOLITHIC MACULA

Sixth Annual Intensive Update in Neurology 0915-162016

60

MACULAE OF THE UTRICLESACCULE

Sixth Annual Intensive Update in Neurology 0915-162016

61

HAIR CELLS

Sixth Annual Intensive Update in Neurology 0915-162016

62

SCANNING ELECTRON MICROGRAPH OF OTOCONIA

Sixth Annual Intensive Update in Neurology 0915-162016

63

Ocular VEMP

bull Response to loud clicks (80-110 dB) or forehead tap (Halmagyi and Curthoys 2003)

bull Contralateral oculomotor nucleus (CN III)

bull Inferior oblique muscle contraction (8 msec) detected by 5sec event triggered averaging

bull Noninverting electrode inferior to eye

bull Inverting below non-inverting electrode

bull Ground to forehead

bull Normal subjects have very low response

Sixth Annual Intensive Update in Neurology 0915-162016

64

Clinical applications

bull The o-VEMP is a sensitive test of otolithutricular

function

bull Complements vestibular test procedures that assess

semicircular canals

bull Abnormally robust responses are associated with third

window abnormalities such as semicircular canal

dehiscence

bull Serves as an excellent screening test for semicircular

canal dehiscence

Sixth Annual Intensive Update in Neurology 0915-162016

65

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Sixth Annual Intensive Update in Neurology 0915-162016

66

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Answer 1 References at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

67

Enlarged vestibular aqueduct

bull Axial temporal bone CT showing right temporal bone with enlarged vestibular aqueduct (arrow)

bull Vestibular symptoms accompany progressive sensorineural hearing loss in 4-50 of patients in selected series

Sixth Annual Intensive Update in Neurology 0915-162016

68

Migraine

bull Family or personal history of migraine

bull 25 of migraine patients experience spontaneous vertigo (Baloh 1997)

bull Neuhauser criteria(2001) have been used to construct structured diagnostic interviews (Furman 2003)

bull Not always associated with headache

bull Motion sensitivity

bull Medication responsive

Sixth Annual Intensive Update in Neurology 0915-162016

69

ICHD-III beta Criteria for Vestibular Migraine

bull A At least five attacks fulfilling criteria C and D

bull B A current or past history of 11 migraine without aura or 12 migraine with aura

bull C Vestibular symptoms of moderate or severe intensity lasting between 5 minutes and 72 hours

bull D At least 50 associated with one of the following migrainous features

ndash 1 Headaches

ndash 2 Photophobia and phonophobia

ndash 3 Visual Aura

bull E Not better accounted for by another vestibular disorder

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 34: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

34

Question 1

bull The most likely semicircular canal to be affected in

BPPV is

ndash 1) superior

ndash 2) lateral

ndash 3) posterior

ndash 4) combined

Sixth Annual Intensive Update in Neurology 0915-162016

35

Question 1

bull The most likely semicircular canal to be affected in

BPPV is

ndash 1) superior

ndash 2) lateral

ndash 3) posterior

ndash 4) combined

Answer 3 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

36

Acute Vestibular Syndrome

bull Rapid unilateral injury to either peripheral or central

vestibular structures produces prolonged vertigo

(days to weeks)

bull Severe vertigo nausea and vomiting spontaneous

nystagmus and postural instability

Sixth Annual Intensive Update in Neurology 0915-162016

37

Acute Vestibular Syndrome

bull 25 of patients with risk factors who present with isolated severe vertigo nystagmus and postural instability in the ER have an acute infarction of the inferior cerebellum (AICA PICA) Central imaging is suggested (Baloh 1998 NEJM)

ndash HTN diabetes smoking age gt65 Afib valvular heart disease occlusive vascular disease

Sixth Annual Intensive Update in Neurology 0915-162016

38

HINTS test

bull Head Impulse

bull Nystagmus

bull Test of Skew

ndash More sensitive than MRI in the diagnosis of acute stroke in

patients with acute vestibular syndrome with at least one risk

factor (Kattah J et al Stroke 2009)

Sixth Annual Intensive Update in Neurology 0915-162016

39

Head Impulse Test

bull No special equipment needed

bull Examiner stands in front of seated patient and

randomly moves head left and right Patient is asked to

focus on examinerrsquos nose

bull Rapid low amplitude thrust from lateral to straight

ahead causes a compensatory saccade when

performed towards the weak side

bull This finding is a permanent feature of unilateral

vestibular loss

Sixth Annual Intensive Update in Neurology 0915-162016

40

Head Impulse Test

Sixth Annual Intensive Update in Neurology 0915-162016

41

Head CT ndash Academy of Emergency Medicine 2013

bull The clinical value of head CT in isolated

dizzinessvertigo without any associated neurological

symptoms is very low

bull Less than 1 of head CTs ordered for dizziness and

vertigo have significant abnormalities and those

patients had severe headache and neurological deficits

in addition to dizziness

bull Forgoing unnecessary emergency head CTs could

save 360 million dollars annually

Sixth Annual Intensive Update in Neurology 0915-162016

42

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Sixth Annual Intensive Update in Neurology 0915-162016

43

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Answer 2 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

44

Acute Vestibular Syndrome

bull Usually peripheral and can be associated with

hearing loss (labyrinthitis)

bull Timely diagnosis improves recovery (ASAP

prednisone 1mgkgday for ten days and taper 10

mgday ndash Strupp M 2004 NEJM)

bull Avoid vestibular suppressants after 3 days and begin

vestibular rehabilitation to hasten compensation

Sixth Annual Intensive Update in Neurology 0915-162016

45

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

46

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Answer 5 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

47

Menierersquos syndrome

bull Fluctuating low frequency hearing loss

bull Tinnitus andor aural fullness

bull Vertigo lasting hours

Sixth Annual Intensive Update in Neurology 0915-162016

48

Normal

Sixth Annual Intensive Update in Neurology 0915-162016

49

Hydrops

Sixth Annual Intensive Update in Neurology 0915-162016

50

Menierersquos syndrome

ndash Diagnosis- Exclusion (RO acoustic)

ndash 23 of Menierersquos patients will improve spontaneously

ndash Treatment-1500 mgday low sodium triamterene375-

hydrochlorothiazide 25 vestibular suppressants (lorazepam

1 mg tablet sublingual Q 8 prn attacks) off label use

Sixth Annual Intensive Update in Neurology 0915-162016

51

Menierersquos syndrome ndash intratympanic steroids

ndash A newer treatment option for those failing medical management

ndash 90 response rate (Boleus-Aguirre MS Otology Neurotology

2008)

ndash Outcomes data confirm excellent clinical response in 3941

Menierersquos patients treated with intratympanic steroids in 2008

Sixth Annual Intensive Update in Neurology 0915-162016

52

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

53

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Answer 5 See references at end

Sixth Annual Intensive Update in Neurology 0915-162016

54

Superior Semicircular Canal Dehiscence (SSCD)

bull Sound andor pressure induced oscillopsia

bull CT reformatted in the plane of the superior canals

shows dehiscence of overlying bone

bull Low frequency ldquoconductive hyperacusisrdquo with elevated

bone thresholds normal reflexes and a conductive loss

Sixth Annual Intensive Update in Neurology 0915-162016

55

SSCD

bull Positive middle ear pressure or loud sound stimulates ampullofugal endolymph flow -canal activation

bull Eye movements are tonic upwards with ipsilateral intorsion

Sixth Annual Intensive Update in Neurology 0915-162016

56

SSCD

bull Valsalva against a closed glottis or jugular compression causes increased intracranial pressure and ampullopetal endolymph flow -canal inhibition

bull Eye movements are tonic downwards with ipsilateral extorsion

Sixth Annual Intensive Update in Neurology 0915-162016

57

Reconstructed left superior semicircular canal

Sixth Annual Intensive Update in Neurology 0915-162016

58

Sixth Annual Intensive Update in Neurology 0915-162016

59

SCHEMATIC DRAWING OF AN OTOLITHIC MACULA

Sixth Annual Intensive Update in Neurology 0915-162016

60

MACULAE OF THE UTRICLESACCULE

Sixth Annual Intensive Update in Neurology 0915-162016

61

HAIR CELLS

Sixth Annual Intensive Update in Neurology 0915-162016

62

SCANNING ELECTRON MICROGRAPH OF OTOCONIA

Sixth Annual Intensive Update in Neurology 0915-162016

63

Ocular VEMP

bull Response to loud clicks (80-110 dB) or forehead tap (Halmagyi and Curthoys 2003)

bull Contralateral oculomotor nucleus (CN III)

bull Inferior oblique muscle contraction (8 msec) detected by 5sec event triggered averaging

bull Noninverting electrode inferior to eye

bull Inverting below non-inverting electrode

bull Ground to forehead

bull Normal subjects have very low response

Sixth Annual Intensive Update in Neurology 0915-162016

64

Clinical applications

bull The o-VEMP is a sensitive test of otolithutricular

function

bull Complements vestibular test procedures that assess

semicircular canals

bull Abnormally robust responses are associated with third

window abnormalities such as semicircular canal

dehiscence

bull Serves as an excellent screening test for semicircular

canal dehiscence

Sixth Annual Intensive Update in Neurology 0915-162016

65

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Sixth Annual Intensive Update in Neurology 0915-162016

66

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Answer 1 References at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

67

Enlarged vestibular aqueduct

bull Axial temporal bone CT showing right temporal bone with enlarged vestibular aqueduct (arrow)

bull Vestibular symptoms accompany progressive sensorineural hearing loss in 4-50 of patients in selected series

Sixth Annual Intensive Update in Neurology 0915-162016

68

Migraine

bull Family or personal history of migraine

bull 25 of migraine patients experience spontaneous vertigo (Baloh 1997)

bull Neuhauser criteria(2001) have been used to construct structured diagnostic interviews (Furman 2003)

bull Not always associated with headache

bull Motion sensitivity

bull Medication responsive

Sixth Annual Intensive Update in Neurology 0915-162016

69

ICHD-III beta Criteria for Vestibular Migraine

bull A At least five attacks fulfilling criteria C and D

bull B A current or past history of 11 migraine without aura or 12 migraine with aura

bull C Vestibular symptoms of moderate or severe intensity lasting between 5 minutes and 72 hours

bull D At least 50 associated with one of the following migrainous features

ndash 1 Headaches

ndash 2 Photophobia and phonophobia

ndash 3 Visual Aura

bull E Not better accounted for by another vestibular disorder

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 35: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

35

Question 1

bull The most likely semicircular canal to be affected in

BPPV is

ndash 1) superior

ndash 2) lateral

ndash 3) posterior

ndash 4) combined

Answer 3 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

36

Acute Vestibular Syndrome

bull Rapid unilateral injury to either peripheral or central

vestibular structures produces prolonged vertigo

(days to weeks)

bull Severe vertigo nausea and vomiting spontaneous

nystagmus and postural instability

Sixth Annual Intensive Update in Neurology 0915-162016

37

Acute Vestibular Syndrome

bull 25 of patients with risk factors who present with isolated severe vertigo nystagmus and postural instability in the ER have an acute infarction of the inferior cerebellum (AICA PICA) Central imaging is suggested (Baloh 1998 NEJM)

ndash HTN diabetes smoking age gt65 Afib valvular heart disease occlusive vascular disease

Sixth Annual Intensive Update in Neurology 0915-162016

38

HINTS test

bull Head Impulse

bull Nystagmus

bull Test of Skew

ndash More sensitive than MRI in the diagnosis of acute stroke in

patients with acute vestibular syndrome with at least one risk

factor (Kattah J et al Stroke 2009)

Sixth Annual Intensive Update in Neurology 0915-162016

39

Head Impulse Test

bull No special equipment needed

bull Examiner stands in front of seated patient and

randomly moves head left and right Patient is asked to

focus on examinerrsquos nose

bull Rapid low amplitude thrust from lateral to straight

ahead causes a compensatory saccade when

performed towards the weak side

bull This finding is a permanent feature of unilateral

vestibular loss

Sixth Annual Intensive Update in Neurology 0915-162016

40

Head Impulse Test

Sixth Annual Intensive Update in Neurology 0915-162016

41

Head CT ndash Academy of Emergency Medicine 2013

bull The clinical value of head CT in isolated

dizzinessvertigo without any associated neurological

symptoms is very low

bull Less than 1 of head CTs ordered for dizziness and

vertigo have significant abnormalities and those

patients had severe headache and neurological deficits

in addition to dizziness

bull Forgoing unnecessary emergency head CTs could

save 360 million dollars annually

Sixth Annual Intensive Update in Neurology 0915-162016

42

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Sixth Annual Intensive Update in Neurology 0915-162016

43

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Answer 2 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

44

Acute Vestibular Syndrome

bull Usually peripheral and can be associated with

hearing loss (labyrinthitis)

bull Timely diagnosis improves recovery (ASAP

prednisone 1mgkgday for ten days and taper 10

mgday ndash Strupp M 2004 NEJM)

bull Avoid vestibular suppressants after 3 days and begin

vestibular rehabilitation to hasten compensation

Sixth Annual Intensive Update in Neurology 0915-162016

45

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

46

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Answer 5 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

47

Menierersquos syndrome

bull Fluctuating low frequency hearing loss

bull Tinnitus andor aural fullness

bull Vertigo lasting hours

Sixth Annual Intensive Update in Neurology 0915-162016

48

Normal

Sixth Annual Intensive Update in Neurology 0915-162016

49

Hydrops

Sixth Annual Intensive Update in Neurology 0915-162016

50

Menierersquos syndrome

ndash Diagnosis- Exclusion (RO acoustic)

ndash 23 of Menierersquos patients will improve spontaneously

ndash Treatment-1500 mgday low sodium triamterene375-

hydrochlorothiazide 25 vestibular suppressants (lorazepam

1 mg tablet sublingual Q 8 prn attacks) off label use

Sixth Annual Intensive Update in Neurology 0915-162016

51

Menierersquos syndrome ndash intratympanic steroids

ndash A newer treatment option for those failing medical management

ndash 90 response rate (Boleus-Aguirre MS Otology Neurotology

2008)

ndash Outcomes data confirm excellent clinical response in 3941

Menierersquos patients treated with intratympanic steroids in 2008

Sixth Annual Intensive Update in Neurology 0915-162016

52

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

53

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Answer 5 See references at end

Sixth Annual Intensive Update in Neurology 0915-162016

54

Superior Semicircular Canal Dehiscence (SSCD)

bull Sound andor pressure induced oscillopsia

bull CT reformatted in the plane of the superior canals

shows dehiscence of overlying bone

bull Low frequency ldquoconductive hyperacusisrdquo with elevated

bone thresholds normal reflexes and a conductive loss

Sixth Annual Intensive Update in Neurology 0915-162016

55

SSCD

bull Positive middle ear pressure or loud sound stimulates ampullofugal endolymph flow -canal activation

bull Eye movements are tonic upwards with ipsilateral intorsion

Sixth Annual Intensive Update in Neurology 0915-162016

56

SSCD

bull Valsalva against a closed glottis or jugular compression causes increased intracranial pressure and ampullopetal endolymph flow -canal inhibition

bull Eye movements are tonic downwards with ipsilateral extorsion

Sixth Annual Intensive Update in Neurology 0915-162016

57

Reconstructed left superior semicircular canal

Sixth Annual Intensive Update in Neurology 0915-162016

58

Sixth Annual Intensive Update in Neurology 0915-162016

59

SCHEMATIC DRAWING OF AN OTOLITHIC MACULA

Sixth Annual Intensive Update in Neurology 0915-162016

60

MACULAE OF THE UTRICLESACCULE

Sixth Annual Intensive Update in Neurology 0915-162016

61

HAIR CELLS

Sixth Annual Intensive Update in Neurology 0915-162016

62

SCANNING ELECTRON MICROGRAPH OF OTOCONIA

Sixth Annual Intensive Update in Neurology 0915-162016

63

Ocular VEMP

bull Response to loud clicks (80-110 dB) or forehead tap (Halmagyi and Curthoys 2003)

bull Contralateral oculomotor nucleus (CN III)

bull Inferior oblique muscle contraction (8 msec) detected by 5sec event triggered averaging

bull Noninverting electrode inferior to eye

bull Inverting below non-inverting electrode

bull Ground to forehead

bull Normal subjects have very low response

Sixth Annual Intensive Update in Neurology 0915-162016

64

Clinical applications

bull The o-VEMP is a sensitive test of otolithutricular

function

bull Complements vestibular test procedures that assess

semicircular canals

bull Abnormally robust responses are associated with third

window abnormalities such as semicircular canal

dehiscence

bull Serves as an excellent screening test for semicircular

canal dehiscence

Sixth Annual Intensive Update in Neurology 0915-162016

65

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Sixth Annual Intensive Update in Neurology 0915-162016

66

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Answer 1 References at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

67

Enlarged vestibular aqueduct

bull Axial temporal bone CT showing right temporal bone with enlarged vestibular aqueduct (arrow)

bull Vestibular symptoms accompany progressive sensorineural hearing loss in 4-50 of patients in selected series

Sixth Annual Intensive Update in Neurology 0915-162016

68

Migraine

bull Family or personal history of migraine

bull 25 of migraine patients experience spontaneous vertigo (Baloh 1997)

bull Neuhauser criteria(2001) have been used to construct structured diagnostic interviews (Furman 2003)

bull Not always associated with headache

bull Motion sensitivity

bull Medication responsive

Sixth Annual Intensive Update in Neurology 0915-162016

69

ICHD-III beta Criteria for Vestibular Migraine

bull A At least five attacks fulfilling criteria C and D

bull B A current or past history of 11 migraine without aura or 12 migraine with aura

bull C Vestibular symptoms of moderate or severe intensity lasting between 5 minutes and 72 hours

bull D At least 50 associated with one of the following migrainous features

ndash 1 Headaches

ndash 2 Photophobia and phonophobia

ndash 3 Visual Aura

bull E Not better accounted for by another vestibular disorder

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 36: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

36

Acute Vestibular Syndrome

bull Rapid unilateral injury to either peripheral or central

vestibular structures produces prolonged vertigo

(days to weeks)

bull Severe vertigo nausea and vomiting spontaneous

nystagmus and postural instability

Sixth Annual Intensive Update in Neurology 0915-162016

37

Acute Vestibular Syndrome

bull 25 of patients with risk factors who present with isolated severe vertigo nystagmus and postural instability in the ER have an acute infarction of the inferior cerebellum (AICA PICA) Central imaging is suggested (Baloh 1998 NEJM)

ndash HTN diabetes smoking age gt65 Afib valvular heart disease occlusive vascular disease

Sixth Annual Intensive Update in Neurology 0915-162016

38

HINTS test

bull Head Impulse

bull Nystagmus

bull Test of Skew

ndash More sensitive than MRI in the diagnosis of acute stroke in

patients with acute vestibular syndrome with at least one risk

factor (Kattah J et al Stroke 2009)

Sixth Annual Intensive Update in Neurology 0915-162016

39

Head Impulse Test

bull No special equipment needed

bull Examiner stands in front of seated patient and

randomly moves head left and right Patient is asked to

focus on examinerrsquos nose

bull Rapid low amplitude thrust from lateral to straight

ahead causes a compensatory saccade when

performed towards the weak side

bull This finding is a permanent feature of unilateral

vestibular loss

Sixth Annual Intensive Update in Neurology 0915-162016

40

Head Impulse Test

Sixth Annual Intensive Update in Neurology 0915-162016

41

Head CT ndash Academy of Emergency Medicine 2013

bull The clinical value of head CT in isolated

dizzinessvertigo without any associated neurological

symptoms is very low

bull Less than 1 of head CTs ordered for dizziness and

vertigo have significant abnormalities and those

patients had severe headache and neurological deficits

in addition to dizziness

bull Forgoing unnecessary emergency head CTs could

save 360 million dollars annually

Sixth Annual Intensive Update in Neurology 0915-162016

42

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Sixth Annual Intensive Update in Neurology 0915-162016

43

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Answer 2 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

44

Acute Vestibular Syndrome

bull Usually peripheral and can be associated with

hearing loss (labyrinthitis)

bull Timely diagnosis improves recovery (ASAP

prednisone 1mgkgday for ten days and taper 10

mgday ndash Strupp M 2004 NEJM)

bull Avoid vestibular suppressants after 3 days and begin

vestibular rehabilitation to hasten compensation

Sixth Annual Intensive Update in Neurology 0915-162016

45

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

46

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Answer 5 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

47

Menierersquos syndrome

bull Fluctuating low frequency hearing loss

bull Tinnitus andor aural fullness

bull Vertigo lasting hours

Sixth Annual Intensive Update in Neurology 0915-162016

48

Normal

Sixth Annual Intensive Update in Neurology 0915-162016

49

Hydrops

Sixth Annual Intensive Update in Neurology 0915-162016

50

Menierersquos syndrome

ndash Diagnosis- Exclusion (RO acoustic)

ndash 23 of Menierersquos patients will improve spontaneously

ndash Treatment-1500 mgday low sodium triamterene375-

hydrochlorothiazide 25 vestibular suppressants (lorazepam

1 mg tablet sublingual Q 8 prn attacks) off label use

Sixth Annual Intensive Update in Neurology 0915-162016

51

Menierersquos syndrome ndash intratympanic steroids

ndash A newer treatment option for those failing medical management

ndash 90 response rate (Boleus-Aguirre MS Otology Neurotology

2008)

ndash Outcomes data confirm excellent clinical response in 3941

Menierersquos patients treated with intratympanic steroids in 2008

Sixth Annual Intensive Update in Neurology 0915-162016

52

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

53

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Answer 5 See references at end

Sixth Annual Intensive Update in Neurology 0915-162016

54

Superior Semicircular Canal Dehiscence (SSCD)

bull Sound andor pressure induced oscillopsia

bull CT reformatted in the plane of the superior canals

shows dehiscence of overlying bone

bull Low frequency ldquoconductive hyperacusisrdquo with elevated

bone thresholds normal reflexes and a conductive loss

Sixth Annual Intensive Update in Neurology 0915-162016

55

SSCD

bull Positive middle ear pressure or loud sound stimulates ampullofugal endolymph flow -canal activation

bull Eye movements are tonic upwards with ipsilateral intorsion

Sixth Annual Intensive Update in Neurology 0915-162016

56

SSCD

bull Valsalva against a closed glottis or jugular compression causes increased intracranial pressure and ampullopetal endolymph flow -canal inhibition

bull Eye movements are tonic downwards with ipsilateral extorsion

Sixth Annual Intensive Update in Neurology 0915-162016

57

Reconstructed left superior semicircular canal

Sixth Annual Intensive Update in Neurology 0915-162016

58

Sixth Annual Intensive Update in Neurology 0915-162016

59

SCHEMATIC DRAWING OF AN OTOLITHIC MACULA

Sixth Annual Intensive Update in Neurology 0915-162016

60

MACULAE OF THE UTRICLESACCULE

Sixth Annual Intensive Update in Neurology 0915-162016

61

HAIR CELLS

Sixth Annual Intensive Update in Neurology 0915-162016

62

SCANNING ELECTRON MICROGRAPH OF OTOCONIA

Sixth Annual Intensive Update in Neurology 0915-162016

63

Ocular VEMP

bull Response to loud clicks (80-110 dB) or forehead tap (Halmagyi and Curthoys 2003)

bull Contralateral oculomotor nucleus (CN III)

bull Inferior oblique muscle contraction (8 msec) detected by 5sec event triggered averaging

bull Noninverting electrode inferior to eye

bull Inverting below non-inverting electrode

bull Ground to forehead

bull Normal subjects have very low response

Sixth Annual Intensive Update in Neurology 0915-162016

64

Clinical applications

bull The o-VEMP is a sensitive test of otolithutricular

function

bull Complements vestibular test procedures that assess

semicircular canals

bull Abnormally robust responses are associated with third

window abnormalities such as semicircular canal

dehiscence

bull Serves as an excellent screening test for semicircular

canal dehiscence

Sixth Annual Intensive Update in Neurology 0915-162016

65

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Sixth Annual Intensive Update in Neurology 0915-162016

66

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Answer 1 References at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

67

Enlarged vestibular aqueduct

bull Axial temporal bone CT showing right temporal bone with enlarged vestibular aqueduct (arrow)

bull Vestibular symptoms accompany progressive sensorineural hearing loss in 4-50 of patients in selected series

Sixth Annual Intensive Update in Neurology 0915-162016

68

Migraine

bull Family or personal history of migraine

bull 25 of migraine patients experience spontaneous vertigo (Baloh 1997)

bull Neuhauser criteria(2001) have been used to construct structured diagnostic interviews (Furman 2003)

bull Not always associated with headache

bull Motion sensitivity

bull Medication responsive

Sixth Annual Intensive Update in Neurology 0915-162016

69

ICHD-III beta Criteria for Vestibular Migraine

bull A At least five attacks fulfilling criteria C and D

bull B A current or past history of 11 migraine without aura or 12 migraine with aura

bull C Vestibular symptoms of moderate or severe intensity lasting between 5 minutes and 72 hours

bull D At least 50 associated with one of the following migrainous features

ndash 1 Headaches

ndash 2 Photophobia and phonophobia

ndash 3 Visual Aura

bull E Not better accounted for by another vestibular disorder

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 37: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

37

Acute Vestibular Syndrome

bull 25 of patients with risk factors who present with isolated severe vertigo nystagmus and postural instability in the ER have an acute infarction of the inferior cerebellum (AICA PICA) Central imaging is suggested (Baloh 1998 NEJM)

ndash HTN diabetes smoking age gt65 Afib valvular heart disease occlusive vascular disease

Sixth Annual Intensive Update in Neurology 0915-162016

38

HINTS test

bull Head Impulse

bull Nystagmus

bull Test of Skew

ndash More sensitive than MRI in the diagnosis of acute stroke in

patients with acute vestibular syndrome with at least one risk

factor (Kattah J et al Stroke 2009)

Sixth Annual Intensive Update in Neurology 0915-162016

39

Head Impulse Test

bull No special equipment needed

bull Examiner stands in front of seated patient and

randomly moves head left and right Patient is asked to

focus on examinerrsquos nose

bull Rapid low amplitude thrust from lateral to straight

ahead causes a compensatory saccade when

performed towards the weak side

bull This finding is a permanent feature of unilateral

vestibular loss

Sixth Annual Intensive Update in Neurology 0915-162016

40

Head Impulse Test

Sixth Annual Intensive Update in Neurology 0915-162016

41

Head CT ndash Academy of Emergency Medicine 2013

bull The clinical value of head CT in isolated

dizzinessvertigo without any associated neurological

symptoms is very low

bull Less than 1 of head CTs ordered for dizziness and

vertigo have significant abnormalities and those

patients had severe headache and neurological deficits

in addition to dizziness

bull Forgoing unnecessary emergency head CTs could

save 360 million dollars annually

Sixth Annual Intensive Update in Neurology 0915-162016

42

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Sixth Annual Intensive Update in Neurology 0915-162016

43

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Answer 2 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

44

Acute Vestibular Syndrome

bull Usually peripheral and can be associated with

hearing loss (labyrinthitis)

bull Timely diagnosis improves recovery (ASAP

prednisone 1mgkgday for ten days and taper 10

mgday ndash Strupp M 2004 NEJM)

bull Avoid vestibular suppressants after 3 days and begin

vestibular rehabilitation to hasten compensation

Sixth Annual Intensive Update in Neurology 0915-162016

45

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

46

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Answer 5 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

47

Menierersquos syndrome

bull Fluctuating low frequency hearing loss

bull Tinnitus andor aural fullness

bull Vertigo lasting hours

Sixth Annual Intensive Update in Neurology 0915-162016

48

Normal

Sixth Annual Intensive Update in Neurology 0915-162016

49

Hydrops

Sixth Annual Intensive Update in Neurology 0915-162016

50

Menierersquos syndrome

ndash Diagnosis- Exclusion (RO acoustic)

ndash 23 of Menierersquos patients will improve spontaneously

ndash Treatment-1500 mgday low sodium triamterene375-

hydrochlorothiazide 25 vestibular suppressants (lorazepam

1 mg tablet sublingual Q 8 prn attacks) off label use

Sixth Annual Intensive Update in Neurology 0915-162016

51

Menierersquos syndrome ndash intratympanic steroids

ndash A newer treatment option for those failing medical management

ndash 90 response rate (Boleus-Aguirre MS Otology Neurotology

2008)

ndash Outcomes data confirm excellent clinical response in 3941

Menierersquos patients treated with intratympanic steroids in 2008

Sixth Annual Intensive Update in Neurology 0915-162016

52

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

53

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Answer 5 See references at end

Sixth Annual Intensive Update in Neurology 0915-162016

54

Superior Semicircular Canal Dehiscence (SSCD)

bull Sound andor pressure induced oscillopsia

bull CT reformatted in the plane of the superior canals

shows dehiscence of overlying bone

bull Low frequency ldquoconductive hyperacusisrdquo with elevated

bone thresholds normal reflexes and a conductive loss

Sixth Annual Intensive Update in Neurology 0915-162016

55

SSCD

bull Positive middle ear pressure or loud sound stimulates ampullofugal endolymph flow -canal activation

bull Eye movements are tonic upwards with ipsilateral intorsion

Sixth Annual Intensive Update in Neurology 0915-162016

56

SSCD

bull Valsalva against a closed glottis or jugular compression causes increased intracranial pressure and ampullopetal endolymph flow -canal inhibition

bull Eye movements are tonic downwards with ipsilateral extorsion

Sixth Annual Intensive Update in Neurology 0915-162016

57

Reconstructed left superior semicircular canal

Sixth Annual Intensive Update in Neurology 0915-162016

58

Sixth Annual Intensive Update in Neurology 0915-162016

59

SCHEMATIC DRAWING OF AN OTOLITHIC MACULA

Sixth Annual Intensive Update in Neurology 0915-162016

60

MACULAE OF THE UTRICLESACCULE

Sixth Annual Intensive Update in Neurology 0915-162016

61

HAIR CELLS

Sixth Annual Intensive Update in Neurology 0915-162016

62

SCANNING ELECTRON MICROGRAPH OF OTOCONIA

Sixth Annual Intensive Update in Neurology 0915-162016

63

Ocular VEMP

bull Response to loud clicks (80-110 dB) or forehead tap (Halmagyi and Curthoys 2003)

bull Contralateral oculomotor nucleus (CN III)

bull Inferior oblique muscle contraction (8 msec) detected by 5sec event triggered averaging

bull Noninverting electrode inferior to eye

bull Inverting below non-inverting electrode

bull Ground to forehead

bull Normal subjects have very low response

Sixth Annual Intensive Update in Neurology 0915-162016

64

Clinical applications

bull The o-VEMP is a sensitive test of otolithutricular

function

bull Complements vestibular test procedures that assess

semicircular canals

bull Abnormally robust responses are associated with third

window abnormalities such as semicircular canal

dehiscence

bull Serves as an excellent screening test for semicircular

canal dehiscence

Sixth Annual Intensive Update in Neurology 0915-162016

65

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Sixth Annual Intensive Update in Neurology 0915-162016

66

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Answer 1 References at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

67

Enlarged vestibular aqueduct

bull Axial temporal bone CT showing right temporal bone with enlarged vestibular aqueduct (arrow)

bull Vestibular symptoms accompany progressive sensorineural hearing loss in 4-50 of patients in selected series

Sixth Annual Intensive Update in Neurology 0915-162016

68

Migraine

bull Family or personal history of migraine

bull 25 of migraine patients experience spontaneous vertigo (Baloh 1997)

bull Neuhauser criteria(2001) have been used to construct structured diagnostic interviews (Furman 2003)

bull Not always associated with headache

bull Motion sensitivity

bull Medication responsive

Sixth Annual Intensive Update in Neurology 0915-162016

69

ICHD-III beta Criteria for Vestibular Migraine

bull A At least five attacks fulfilling criteria C and D

bull B A current or past history of 11 migraine without aura or 12 migraine with aura

bull C Vestibular symptoms of moderate or severe intensity lasting between 5 minutes and 72 hours

bull D At least 50 associated with one of the following migrainous features

ndash 1 Headaches

ndash 2 Photophobia and phonophobia

ndash 3 Visual Aura

bull E Not better accounted for by another vestibular disorder

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 38: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

38

HINTS test

bull Head Impulse

bull Nystagmus

bull Test of Skew

ndash More sensitive than MRI in the diagnosis of acute stroke in

patients with acute vestibular syndrome with at least one risk

factor (Kattah J et al Stroke 2009)

Sixth Annual Intensive Update in Neurology 0915-162016

39

Head Impulse Test

bull No special equipment needed

bull Examiner stands in front of seated patient and

randomly moves head left and right Patient is asked to

focus on examinerrsquos nose

bull Rapid low amplitude thrust from lateral to straight

ahead causes a compensatory saccade when

performed towards the weak side

bull This finding is a permanent feature of unilateral

vestibular loss

Sixth Annual Intensive Update in Neurology 0915-162016

40

Head Impulse Test

Sixth Annual Intensive Update in Neurology 0915-162016

41

Head CT ndash Academy of Emergency Medicine 2013

bull The clinical value of head CT in isolated

dizzinessvertigo without any associated neurological

symptoms is very low

bull Less than 1 of head CTs ordered for dizziness and

vertigo have significant abnormalities and those

patients had severe headache and neurological deficits

in addition to dizziness

bull Forgoing unnecessary emergency head CTs could

save 360 million dollars annually

Sixth Annual Intensive Update in Neurology 0915-162016

42

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Sixth Annual Intensive Update in Neurology 0915-162016

43

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Answer 2 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

44

Acute Vestibular Syndrome

bull Usually peripheral and can be associated with

hearing loss (labyrinthitis)

bull Timely diagnosis improves recovery (ASAP

prednisone 1mgkgday for ten days and taper 10

mgday ndash Strupp M 2004 NEJM)

bull Avoid vestibular suppressants after 3 days and begin

vestibular rehabilitation to hasten compensation

Sixth Annual Intensive Update in Neurology 0915-162016

45

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

46

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Answer 5 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

47

Menierersquos syndrome

bull Fluctuating low frequency hearing loss

bull Tinnitus andor aural fullness

bull Vertigo lasting hours

Sixth Annual Intensive Update in Neurology 0915-162016

48

Normal

Sixth Annual Intensive Update in Neurology 0915-162016

49

Hydrops

Sixth Annual Intensive Update in Neurology 0915-162016

50

Menierersquos syndrome

ndash Diagnosis- Exclusion (RO acoustic)

ndash 23 of Menierersquos patients will improve spontaneously

ndash Treatment-1500 mgday low sodium triamterene375-

hydrochlorothiazide 25 vestibular suppressants (lorazepam

1 mg tablet sublingual Q 8 prn attacks) off label use

Sixth Annual Intensive Update in Neurology 0915-162016

51

Menierersquos syndrome ndash intratympanic steroids

ndash A newer treatment option for those failing medical management

ndash 90 response rate (Boleus-Aguirre MS Otology Neurotology

2008)

ndash Outcomes data confirm excellent clinical response in 3941

Menierersquos patients treated with intratympanic steroids in 2008

Sixth Annual Intensive Update in Neurology 0915-162016

52

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

53

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Answer 5 See references at end

Sixth Annual Intensive Update in Neurology 0915-162016

54

Superior Semicircular Canal Dehiscence (SSCD)

bull Sound andor pressure induced oscillopsia

bull CT reformatted in the plane of the superior canals

shows dehiscence of overlying bone

bull Low frequency ldquoconductive hyperacusisrdquo with elevated

bone thresholds normal reflexes and a conductive loss

Sixth Annual Intensive Update in Neurology 0915-162016

55

SSCD

bull Positive middle ear pressure or loud sound stimulates ampullofugal endolymph flow -canal activation

bull Eye movements are tonic upwards with ipsilateral intorsion

Sixth Annual Intensive Update in Neurology 0915-162016

56

SSCD

bull Valsalva against a closed glottis or jugular compression causes increased intracranial pressure and ampullopetal endolymph flow -canal inhibition

bull Eye movements are tonic downwards with ipsilateral extorsion

Sixth Annual Intensive Update in Neurology 0915-162016

57

Reconstructed left superior semicircular canal

Sixth Annual Intensive Update in Neurology 0915-162016

58

Sixth Annual Intensive Update in Neurology 0915-162016

59

SCHEMATIC DRAWING OF AN OTOLITHIC MACULA

Sixth Annual Intensive Update in Neurology 0915-162016

60

MACULAE OF THE UTRICLESACCULE

Sixth Annual Intensive Update in Neurology 0915-162016

61

HAIR CELLS

Sixth Annual Intensive Update in Neurology 0915-162016

62

SCANNING ELECTRON MICROGRAPH OF OTOCONIA

Sixth Annual Intensive Update in Neurology 0915-162016

63

Ocular VEMP

bull Response to loud clicks (80-110 dB) or forehead tap (Halmagyi and Curthoys 2003)

bull Contralateral oculomotor nucleus (CN III)

bull Inferior oblique muscle contraction (8 msec) detected by 5sec event triggered averaging

bull Noninverting electrode inferior to eye

bull Inverting below non-inverting electrode

bull Ground to forehead

bull Normal subjects have very low response

Sixth Annual Intensive Update in Neurology 0915-162016

64

Clinical applications

bull The o-VEMP is a sensitive test of otolithutricular

function

bull Complements vestibular test procedures that assess

semicircular canals

bull Abnormally robust responses are associated with third

window abnormalities such as semicircular canal

dehiscence

bull Serves as an excellent screening test for semicircular

canal dehiscence

Sixth Annual Intensive Update in Neurology 0915-162016

65

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Sixth Annual Intensive Update in Neurology 0915-162016

66

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Answer 1 References at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

67

Enlarged vestibular aqueduct

bull Axial temporal bone CT showing right temporal bone with enlarged vestibular aqueduct (arrow)

bull Vestibular symptoms accompany progressive sensorineural hearing loss in 4-50 of patients in selected series

Sixth Annual Intensive Update in Neurology 0915-162016

68

Migraine

bull Family or personal history of migraine

bull 25 of migraine patients experience spontaneous vertigo (Baloh 1997)

bull Neuhauser criteria(2001) have been used to construct structured diagnostic interviews (Furman 2003)

bull Not always associated with headache

bull Motion sensitivity

bull Medication responsive

Sixth Annual Intensive Update in Neurology 0915-162016

69

ICHD-III beta Criteria for Vestibular Migraine

bull A At least five attacks fulfilling criteria C and D

bull B A current or past history of 11 migraine without aura or 12 migraine with aura

bull C Vestibular symptoms of moderate or severe intensity lasting between 5 minutes and 72 hours

bull D At least 50 associated with one of the following migrainous features

ndash 1 Headaches

ndash 2 Photophobia and phonophobia

ndash 3 Visual Aura

bull E Not better accounted for by another vestibular disorder

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 39: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

39

Head Impulse Test

bull No special equipment needed

bull Examiner stands in front of seated patient and

randomly moves head left and right Patient is asked to

focus on examinerrsquos nose

bull Rapid low amplitude thrust from lateral to straight

ahead causes a compensatory saccade when

performed towards the weak side

bull This finding is a permanent feature of unilateral

vestibular loss

Sixth Annual Intensive Update in Neurology 0915-162016

40

Head Impulse Test

Sixth Annual Intensive Update in Neurology 0915-162016

41

Head CT ndash Academy of Emergency Medicine 2013

bull The clinical value of head CT in isolated

dizzinessvertigo without any associated neurological

symptoms is very low

bull Less than 1 of head CTs ordered for dizziness and

vertigo have significant abnormalities and those

patients had severe headache and neurological deficits

in addition to dizziness

bull Forgoing unnecessary emergency head CTs could

save 360 million dollars annually

Sixth Annual Intensive Update in Neurology 0915-162016

42

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Sixth Annual Intensive Update in Neurology 0915-162016

43

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Answer 2 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

44

Acute Vestibular Syndrome

bull Usually peripheral and can be associated with

hearing loss (labyrinthitis)

bull Timely diagnosis improves recovery (ASAP

prednisone 1mgkgday for ten days and taper 10

mgday ndash Strupp M 2004 NEJM)

bull Avoid vestibular suppressants after 3 days and begin

vestibular rehabilitation to hasten compensation

Sixth Annual Intensive Update in Neurology 0915-162016

45

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

46

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Answer 5 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

47

Menierersquos syndrome

bull Fluctuating low frequency hearing loss

bull Tinnitus andor aural fullness

bull Vertigo lasting hours

Sixth Annual Intensive Update in Neurology 0915-162016

48

Normal

Sixth Annual Intensive Update in Neurology 0915-162016

49

Hydrops

Sixth Annual Intensive Update in Neurology 0915-162016

50

Menierersquos syndrome

ndash Diagnosis- Exclusion (RO acoustic)

ndash 23 of Menierersquos patients will improve spontaneously

ndash Treatment-1500 mgday low sodium triamterene375-

hydrochlorothiazide 25 vestibular suppressants (lorazepam

1 mg tablet sublingual Q 8 prn attacks) off label use

Sixth Annual Intensive Update in Neurology 0915-162016

51

Menierersquos syndrome ndash intratympanic steroids

ndash A newer treatment option for those failing medical management

ndash 90 response rate (Boleus-Aguirre MS Otology Neurotology

2008)

ndash Outcomes data confirm excellent clinical response in 3941

Menierersquos patients treated with intratympanic steroids in 2008

Sixth Annual Intensive Update in Neurology 0915-162016

52

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

53

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Answer 5 See references at end

Sixth Annual Intensive Update in Neurology 0915-162016

54

Superior Semicircular Canal Dehiscence (SSCD)

bull Sound andor pressure induced oscillopsia

bull CT reformatted in the plane of the superior canals

shows dehiscence of overlying bone

bull Low frequency ldquoconductive hyperacusisrdquo with elevated

bone thresholds normal reflexes and a conductive loss

Sixth Annual Intensive Update in Neurology 0915-162016

55

SSCD

bull Positive middle ear pressure or loud sound stimulates ampullofugal endolymph flow -canal activation

bull Eye movements are tonic upwards with ipsilateral intorsion

Sixth Annual Intensive Update in Neurology 0915-162016

56

SSCD

bull Valsalva against a closed glottis or jugular compression causes increased intracranial pressure and ampullopetal endolymph flow -canal inhibition

bull Eye movements are tonic downwards with ipsilateral extorsion

Sixth Annual Intensive Update in Neurology 0915-162016

57

Reconstructed left superior semicircular canal

Sixth Annual Intensive Update in Neurology 0915-162016

58

Sixth Annual Intensive Update in Neurology 0915-162016

59

SCHEMATIC DRAWING OF AN OTOLITHIC MACULA

Sixth Annual Intensive Update in Neurology 0915-162016

60

MACULAE OF THE UTRICLESACCULE

Sixth Annual Intensive Update in Neurology 0915-162016

61

HAIR CELLS

Sixth Annual Intensive Update in Neurology 0915-162016

62

SCANNING ELECTRON MICROGRAPH OF OTOCONIA

Sixth Annual Intensive Update in Neurology 0915-162016

63

Ocular VEMP

bull Response to loud clicks (80-110 dB) or forehead tap (Halmagyi and Curthoys 2003)

bull Contralateral oculomotor nucleus (CN III)

bull Inferior oblique muscle contraction (8 msec) detected by 5sec event triggered averaging

bull Noninverting electrode inferior to eye

bull Inverting below non-inverting electrode

bull Ground to forehead

bull Normal subjects have very low response

Sixth Annual Intensive Update in Neurology 0915-162016

64

Clinical applications

bull The o-VEMP is a sensitive test of otolithutricular

function

bull Complements vestibular test procedures that assess

semicircular canals

bull Abnormally robust responses are associated with third

window abnormalities such as semicircular canal

dehiscence

bull Serves as an excellent screening test for semicircular

canal dehiscence

Sixth Annual Intensive Update in Neurology 0915-162016

65

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Sixth Annual Intensive Update in Neurology 0915-162016

66

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Answer 1 References at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

67

Enlarged vestibular aqueduct

bull Axial temporal bone CT showing right temporal bone with enlarged vestibular aqueduct (arrow)

bull Vestibular symptoms accompany progressive sensorineural hearing loss in 4-50 of patients in selected series

Sixth Annual Intensive Update in Neurology 0915-162016

68

Migraine

bull Family or personal history of migraine

bull 25 of migraine patients experience spontaneous vertigo (Baloh 1997)

bull Neuhauser criteria(2001) have been used to construct structured diagnostic interviews (Furman 2003)

bull Not always associated with headache

bull Motion sensitivity

bull Medication responsive

Sixth Annual Intensive Update in Neurology 0915-162016

69

ICHD-III beta Criteria for Vestibular Migraine

bull A At least five attacks fulfilling criteria C and D

bull B A current or past history of 11 migraine without aura or 12 migraine with aura

bull C Vestibular symptoms of moderate or severe intensity lasting between 5 minutes and 72 hours

bull D At least 50 associated with one of the following migrainous features

ndash 1 Headaches

ndash 2 Photophobia and phonophobia

ndash 3 Visual Aura

bull E Not better accounted for by another vestibular disorder

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 40: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

40

Head Impulse Test

Sixth Annual Intensive Update in Neurology 0915-162016

41

Head CT ndash Academy of Emergency Medicine 2013

bull The clinical value of head CT in isolated

dizzinessvertigo without any associated neurological

symptoms is very low

bull Less than 1 of head CTs ordered for dizziness and

vertigo have significant abnormalities and those

patients had severe headache and neurological deficits

in addition to dizziness

bull Forgoing unnecessary emergency head CTs could

save 360 million dollars annually

Sixth Annual Intensive Update in Neurology 0915-162016

42

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Sixth Annual Intensive Update in Neurology 0915-162016

43

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Answer 2 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

44

Acute Vestibular Syndrome

bull Usually peripheral and can be associated with

hearing loss (labyrinthitis)

bull Timely diagnosis improves recovery (ASAP

prednisone 1mgkgday for ten days and taper 10

mgday ndash Strupp M 2004 NEJM)

bull Avoid vestibular suppressants after 3 days and begin

vestibular rehabilitation to hasten compensation

Sixth Annual Intensive Update in Neurology 0915-162016

45

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

46

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Answer 5 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

47

Menierersquos syndrome

bull Fluctuating low frequency hearing loss

bull Tinnitus andor aural fullness

bull Vertigo lasting hours

Sixth Annual Intensive Update in Neurology 0915-162016

48

Normal

Sixth Annual Intensive Update in Neurology 0915-162016

49

Hydrops

Sixth Annual Intensive Update in Neurology 0915-162016

50

Menierersquos syndrome

ndash Diagnosis- Exclusion (RO acoustic)

ndash 23 of Menierersquos patients will improve spontaneously

ndash Treatment-1500 mgday low sodium triamterene375-

hydrochlorothiazide 25 vestibular suppressants (lorazepam

1 mg tablet sublingual Q 8 prn attacks) off label use

Sixth Annual Intensive Update in Neurology 0915-162016

51

Menierersquos syndrome ndash intratympanic steroids

ndash A newer treatment option for those failing medical management

ndash 90 response rate (Boleus-Aguirre MS Otology Neurotology

2008)

ndash Outcomes data confirm excellent clinical response in 3941

Menierersquos patients treated with intratympanic steroids in 2008

Sixth Annual Intensive Update in Neurology 0915-162016

52

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

53

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Answer 5 See references at end

Sixth Annual Intensive Update in Neurology 0915-162016

54

Superior Semicircular Canal Dehiscence (SSCD)

bull Sound andor pressure induced oscillopsia

bull CT reformatted in the plane of the superior canals

shows dehiscence of overlying bone

bull Low frequency ldquoconductive hyperacusisrdquo with elevated

bone thresholds normal reflexes and a conductive loss

Sixth Annual Intensive Update in Neurology 0915-162016

55

SSCD

bull Positive middle ear pressure or loud sound stimulates ampullofugal endolymph flow -canal activation

bull Eye movements are tonic upwards with ipsilateral intorsion

Sixth Annual Intensive Update in Neurology 0915-162016

56

SSCD

bull Valsalva against a closed glottis or jugular compression causes increased intracranial pressure and ampullopetal endolymph flow -canal inhibition

bull Eye movements are tonic downwards with ipsilateral extorsion

Sixth Annual Intensive Update in Neurology 0915-162016

57

Reconstructed left superior semicircular canal

Sixth Annual Intensive Update in Neurology 0915-162016

58

Sixth Annual Intensive Update in Neurology 0915-162016

59

SCHEMATIC DRAWING OF AN OTOLITHIC MACULA

Sixth Annual Intensive Update in Neurology 0915-162016

60

MACULAE OF THE UTRICLESACCULE

Sixth Annual Intensive Update in Neurology 0915-162016

61

HAIR CELLS

Sixth Annual Intensive Update in Neurology 0915-162016

62

SCANNING ELECTRON MICROGRAPH OF OTOCONIA

Sixth Annual Intensive Update in Neurology 0915-162016

63

Ocular VEMP

bull Response to loud clicks (80-110 dB) or forehead tap (Halmagyi and Curthoys 2003)

bull Contralateral oculomotor nucleus (CN III)

bull Inferior oblique muscle contraction (8 msec) detected by 5sec event triggered averaging

bull Noninverting electrode inferior to eye

bull Inverting below non-inverting electrode

bull Ground to forehead

bull Normal subjects have very low response

Sixth Annual Intensive Update in Neurology 0915-162016

64

Clinical applications

bull The o-VEMP is a sensitive test of otolithutricular

function

bull Complements vestibular test procedures that assess

semicircular canals

bull Abnormally robust responses are associated with third

window abnormalities such as semicircular canal

dehiscence

bull Serves as an excellent screening test for semicircular

canal dehiscence

Sixth Annual Intensive Update in Neurology 0915-162016

65

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Sixth Annual Intensive Update in Neurology 0915-162016

66

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Answer 1 References at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

67

Enlarged vestibular aqueduct

bull Axial temporal bone CT showing right temporal bone with enlarged vestibular aqueduct (arrow)

bull Vestibular symptoms accompany progressive sensorineural hearing loss in 4-50 of patients in selected series

Sixth Annual Intensive Update in Neurology 0915-162016

68

Migraine

bull Family or personal history of migraine

bull 25 of migraine patients experience spontaneous vertigo (Baloh 1997)

bull Neuhauser criteria(2001) have been used to construct structured diagnostic interviews (Furman 2003)

bull Not always associated with headache

bull Motion sensitivity

bull Medication responsive

Sixth Annual Intensive Update in Neurology 0915-162016

69

ICHD-III beta Criteria for Vestibular Migraine

bull A At least five attacks fulfilling criteria C and D

bull B A current or past history of 11 migraine without aura or 12 migraine with aura

bull C Vestibular symptoms of moderate or severe intensity lasting between 5 minutes and 72 hours

bull D At least 50 associated with one of the following migrainous features

ndash 1 Headaches

ndash 2 Photophobia and phonophobia

ndash 3 Visual Aura

bull E Not better accounted for by another vestibular disorder

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 41: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

41

Head CT ndash Academy of Emergency Medicine 2013

bull The clinical value of head CT in isolated

dizzinessvertigo without any associated neurological

symptoms is very low

bull Less than 1 of head CTs ordered for dizziness and

vertigo have significant abnormalities and those

patients had severe headache and neurological deficits

in addition to dizziness

bull Forgoing unnecessary emergency head CTs could

save 360 million dollars annually

Sixth Annual Intensive Update in Neurology 0915-162016

42

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Sixth Annual Intensive Update in Neurology 0915-162016

43

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Answer 2 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

44

Acute Vestibular Syndrome

bull Usually peripheral and can be associated with

hearing loss (labyrinthitis)

bull Timely diagnosis improves recovery (ASAP

prednisone 1mgkgday for ten days and taper 10

mgday ndash Strupp M 2004 NEJM)

bull Avoid vestibular suppressants after 3 days and begin

vestibular rehabilitation to hasten compensation

Sixth Annual Intensive Update in Neurology 0915-162016

45

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

46

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Answer 5 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

47

Menierersquos syndrome

bull Fluctuating low frequency hearing loss

bull Tinnitus andor aural fullness

bull Vertigo lasting hours

Sixth Annual Intensive Update in Neurology 0915-162016

48

Normal

Sixth Annual Intensive Update in Neurology 0915-162016

49

Hydrops

Sixth Annual Intensive Update in Neurology 0915-162016

50

Menierersquos syndrome

ndash Diagnosis- Exclusion (RO acoustic)

ndash 23 of Menierersquos patients will improve spontaneously

ndash Treatment-1500 mgday low sodium triamterene375-

hydrochlorothiazide 25 vestibular suppressants (lorazepam

1 mg tablet sublingual Q 8 prn attacks) off label use

Sixth Annual Intensive Update in Neurology 0915-162016

51

Menierersquos syndrome ndash intratympanic steroids

ndash A newer treatment option for those failing medical management

ndash 90 response rate (Boleus-Aguirre MS Otology Neurotology

2008)

ndash Outcomes data confirm excellent clinical response in 3941

Menierersquos patients treated with intratympanic steroids in 2008

Sixth Annual Intensive Update in Neurology 0915-162016

52

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

53

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Answer 5 See references at end

Sixth Annual Intensive Update in Neurology 0915-162016

54

Superior Semicircular Canal Dehiscence (SSCD)

bull Sound andor pressure induced oscillopsia

bull CT reformatted in the plane of the superior canals

shows dehiscence of overlying bone

bull Low frequency ldquoconductive hyperacusisrdquo with elevated

bone thresholds normal reflexes and a conductive loss

Sixth Annual Intensive Update in Neurology 0915-162016

55

SSCD

bull Positive middle ear pressure or loud sound stimulates ampullofugal endolymph flow -canal activation

bull Eye movements are tonic upwards with ipsilateral intorsion

Sixth Annual Intensive Update in Neurology 0915-162016

56

SSCD

bull Valsalva against a closed glottis or jugular compression causes increased intracranial pressure and ampullopetal endolymph flow -canal inhibition

bull Eye movements are tonic downwards with ipsilateral extorsion

Sixth Annual Intensive Update in Neurology 0915-162016

57

Reconstructed left superior semicircular canal

Sixth Annual Intensive Update in Neurology 0915-162016

58

Sixth Annual Intensive Update in Neurology 0915-162016

59

SCHEMATIC DRAWING OF AN OTOLITHIC MACULA

Sixth Annual Intensive Update in Neurology 0915-162016

60

MACULAE OF THE UTRICLESACCULE

Sixth Annual Intensive Update in Neurology 0915-162016

61

HAIR CELLS

Sixth Annual Intensive Update in Neurology 0915-162016

62

SCANNING ELECTRON MICROGRAPH OF OTOCONIA

Sixth Annual Intensive Update in Neurology 0915-162016

63

Ocular VEMP

bull Response to loud clicks (80-110 dB) or forehead tap (Halmagyi and Curthoys 2003)

bull Contralateral oculomotor nucleus (CN III)

bull Inferior oblique muscle contraction (8 msec) detected by 5sec event triggered averaging

bull Noninverting electrode inferior to eye

bull Inverting below non-inverting electrode

bull Ground to forehead

bull Normal subjects have very low response

Sixth Annual Intensive Update in Neurology 0915-162016

64

Clinical applications

bull The o-VEMP is a sensitive test of otolithutricular

function

bull Complements vestibular test procedures that assess

semicircular canals

bull Abnormally robust responses are associated with third

window abnormalities such as semicircular canal

dehiscence

bull Serves as an excellent screening test for semicircular

canal dehiscence

Sixth Annual Intensive Update in Neurology 0915-162016

65

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Sixth Annual Intensive Update in Neurology 0915-162016

66

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Answer 1 References at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

67

Enlarged vestibular aqueduct

bull Axial temporal bone CT showing right temporal bone with enlarged vestibular aqueduct (arrow)

bull Vestibular symptoms accompany progressive sensorineural hearing loss in 4-50 of patients in selected series

Sixth Annual Intensive Update in Neurology 0915-162016

68

Migraine

bull Family or personal history of migraine

bull 25 of migraine patients experience spontaneous vertigo (Baloh 1997)

bull Neuhauser criteria(2001) have been used to construct structured diagnostic interviews (Furman 2003)

bull Not always associated with headache

bull Motion sensitivity

bull Medication responsive

Sixth Annual Intensive Update in Neurology 0915-162016

69

ICHD-III beta Criteria for Vestibular Migraine

bull A At least five attacks fulfilling criteria C and D

bull B A current or past history of 11 migraine without aura or 12 migraine with aura

bull C Vestibular symptoms of moderate or severe intensity lasting between 5 minutes and 72 hours

bull D At least 50 associated with one of the following migrainous features

ndash 1 Headaches

ndash 2 Photophobia and phonophobia

ndash 3 Visual Aura

bull E Not better accounted for by another vestibular disorder

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 42: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

42

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Sixth Annual Intensive Update in Neurology 0915-162016

43

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Answer 2 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

44

Acute Vestibular Syndrome

bull Usually peripheral and can be associated with

hearing loss (labyrinthitis)

bull Timely diagnosis improves recovery (ASAP

prednisone 1mgkgday for ten days and taper 10

mgday ndash Strupp M 2004 NEJM)

bull Avoid vestibular suppressants after 3 days and begin

vestibular rehabilitation to hasten compensation

Sixth Annual Intensive Update in Neurology 0915-162016

45

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

46

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Answer 5 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

47

Menierersquos syndrome

bull Fluctuating low frequency hearing loss

bull Tinnitus andor aural fullness

bull Vertigo lasting hours

Sixth Annual Intensive Update in Neurology 0915-162016

48

Normal

Sixth Annual Intensive Update in Neurology 0915-162016

49

Hydrops

Sixth Annual Intensive Update in Neurology 0915-162016

50

Menierersquos syndrome

ndash Diagnosis- Exclusion (RO acoustic)

ndash 23 of Menierersquos patients will improve spontaneously

ndash Treatment-1500 mgday low sodium triamterene375-

hydrochlorothiazide 25 vestibular suppressants (lorazepam

1 mg tablet sublingual Q 8 prn attacks) off label use

Sixth Annual Intensive Update in Neurology 0915-162016

51

Menierersquos syndrome ndash intratympanic steroids

ndash A newer treatment option for those failing medical management

ndash 90 response rate (Boleus-Aguirre MS Otology Neurotology

2008)

ndash Outcomes data confirm excellent clinical response in 3941

Menierersquos patients treated with intratympanic steroids in 2008

Sixth Annual Intensive Update in Neurology 0915-162016

52

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

53

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Answer 5 See references at end

Sixth Annual Intensive Update in Neurology 0915-162016

54

Superior Semicircular Canal Dehiscence (SSCD)

bull Sound andor pressure induced oscillopsia

bull CT reformatted in the plane of the superior canals

shows dehiscence of overlying bone

bull Low frequency ldquoconductive hyperacusisrdquo with elevated

bone thresholds normal reflexes and a conductive loss

Sixth Annual Intensive Update in Neurology 0915-162016

55

SSCD

bull Positive middle ear pressure or loud sound stimulates ampullofugal endolymph flow -canal activation

bull Eye movements are tonic upwards with ipsilateral intorsion

Sixth Annual Intensive Update in Neurology 0915-162016

56

SSCD

bull Valsalva against a closed glottis or jugular compression causes increased intracranial pressure and ampullopetal endolymph flow -canal inhibition

bull Eye movements are tonic downwards with ipsilateral extorsion

Sixth Annual Intensive Update in Neurology 0915-162016

57

Reconstructed left superior semicircular canal

Sixth Annual Intensive Update in Neurology 0915-162016

58

Sixth Annual Intensive Update in Neurology 0915-162016

59

SCHEMATIC DRAWING OF AN OTOLITHIC MACULA

Sixth Annual Intensive Update in Neurology 0915-162016

60

MACULAE OF THE UTRICLESACCULE

Sixth Annual Intensive Update in Neurology 0915-162016

61

HAIR CELLS

Sixth Annual Intensive Update in Neurology 0915-162016

62

SCANNING ELECTRON MICROGRAPH OF OTOCONIA

Sixth Annual Intensive Update in Neurology 0915-162016

63

Ocular VEMP

bull Response to loud clicks (80-110 dB) or forehead tap (Halmagyi and Curthoys 2003)

bull Contralateral oculomotor nucleus (CN III)

bull Inferior oblique muscle contraction (8 msec) detected by 5sec event triggered averaging

bull Noninverting electrode inferior to eye

bull Inverting below non-inverting electrode

bull Ground to forehead

bull Normal subjects have very low response

Sixth Annual Intensive Update in Neurology 0915-162016

64

Clinical applications

bull The o-VEMP is a sensitive test of otolithutricular

function

bull Complements vestibular test procedures that assess

semicircular canals

bull Abnormally robust responses are associated with third

window abnormalities such as semicircular canal

dehiscence

bull Serves as an excellent screening test for semicircular

canal dehiscence

Sixth Annual Intensive Update in Neurology 0915-162016

65

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Sixth Annual Intensive Update in Neurology 0915-162016

66

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Answer 1 References at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

67

Enlarged vestibular aqueduct

bull Axial temporal bone CT showing right temporal bone with enlarged vestibular aqueduct (arrow)

bull Vestibular symptoms accompany progressive sensorineural hearing loss in 4-50 of patients in selected series

Sixth Annual Intensive Update in Neurology 0915-162016

68

Migraine

bull Family or personal history of migraine

bull 25 of migraine patients experience spontaneous vertigo (Baloh 1997)

bull Neuhauser criteria(2001) have been used to construct structured diagnostic interviews (Furman 2003)

bull Not always associated with headache

bull Motion sensitivity

bull Medication responsive

Sixth Annual Intensive Update in Neurology 0915-162016

69

ICHD-III beta Criteria for Vestibular Migraine

bull A At least five attacks fulfilling criteria C and D

bull B A current or past history of 11 migraine without aura or 12 migraine with aura

bull C Vestibular symptoms of moderate or severe intensity lasting between 5 minutes and 72 hours

bull D At least 50 associated with one of the following migrainous features

ndash 1 Headaches

ndash 2 Photophobia and phonophobia

ndash 3 Visual Aura

bull E Not better accounted for by another vestibular disorder

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 43: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

43

Question 2

Head CT is not indicated for the evaluation of dizziness

and vertigo without additional neurological complaints because

1 It is too expensive

2 Less than 1 of CTs done for dizziness and vertigo are

abnormal and those patients had associated severe

neurological complaints

3 CT is the best imaging choice for the posterior fossa

4 Acoustic neuromas are well seen on CT

Answer 2 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

44

Acute Vestibular Syndrome

bull Usually peripheral and can be associated with

hearing loss (labyrinthitis)

bull Timely diagnosis improves recovery (ASAP

prednisone 1mgkgday for ten days and taper 10

mgday ndash Strupp M 2004 NEJM)

bull Avoid vestibular suppressants after 3 days and begin

vestibular rehabilitation to hasten compensation

Sixth Annual Intensive Update in Neurology 0915-162016

45

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

46

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Answer 5 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

47

Menierersquos syndrome

bull Fluctuating low frequency hearing loss

bull Tinnitus andor aural fullness

bull Vertigo lasting hours

Sixth Annual Intensive Update in Neurology 0915-162016

48

Normal

Sixth Annual Intensive Update in Neurology 0915-162016

49

Hydrops

Sixth Annual Intensive Update in Neurology 0915-162016

50

Menierersquos syndrome

ndash Diagnosis- Exclusion (RO acoustic)

ndash 23 of Menierersquos patients will improve spontaneously

ndash Treatment-1500 mgday low sodium triamterene375-

hydrochlorothiazide 25 vestibular suppressants (lorazepam

1 mg tablet sublingual Q 8 prn attacks) off label use

Sixth Annual Intensive Update in Neurology 0915-162016

51

Menierersquos syndrome ndash intratympanic steroids

ndash A newer treatment option for those failing medical management

ndash 90 response rate (Boleus-Aguirre MS Otology Neurotology

2008)

ndash Outcomes data confirm excellent clinical response in 3941

Menierersquos patients treated with intratympanic steroids in 2008

Sixth Annual Intensive Update in Neurology 0915-162016

52

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

53

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Answer 5 See references at end

Sixth Annual Intensive Update in Neurology 0915-162016

54

Superior Semicircular Canal Dehiscence (SSCD)

bull Sound andor pressure induced oscillopsia

bull CT reformatted in the plane of the superior canals

shows dehiscence of overlying bone

bull Low frequency ldquoconductive hyperacusisrdquo with elevated

bone thresholds normal reflexes and a conductive loss

Sixth Annual Intensive Update in Neurology 0915-162016

55

SSCD

bull Positive middle ear pressure or loud sound stimulates ampullofugal endolymph flow -canal activation

bull Eye movements are tonic upwards with ipsilateral intorsion

Sixth Annual Intensive Update in Neurology 0915-162016

56

SSCD

bull Valsalva against a closed glottis or jugular compression causes increased intracranial pressure and ampullopetal endolymph flow -canal inhibition

bull Eye movements are tonic downwards with ipsilateral extorsion

Sixth Annual Intensive Update in Neurology 0915-162016

57

Reconstructed left superior semicircular canal

Sixth Annual Intensive Update in Neurology 0915-162016

58

Sixth Annual Intensive Update in Neurology 0915-162016

59

SCHEMATIC DRAWING OF AN OTOLITHIC MACULA

Sixth Annual Intensive Update in Neurology 0915-162016

60

MACULAE OF THE UTRICLESACCULE

Sixth Annual Intensive Update in Neurology 0915-162016

61

HAIR CELLS

Sixth Annual Intensive Update in Neurology 0915-162016

62

SCANNING ELECTRON MICROGRAPH OF OTOCONIA

Sixth Annual Intensive Update in Neurology 0915-162016

63

Ocular VEMP

bull Response to loud clicks (80-110 dB) or forehead tap (Halmagyi and Curthoys 2003)

bull Contralateral oculomotor nucleus (CN III)

bull Inferior oblique muscle contraction (8 msec) detected by 5sec event triggered averaging

bull Noninverting electrode inferior to eye

bull Inverting below non-inverting electrode

bull Ground to forehead

bull Normal subjects have very low response

Sixth Annual Intensive Update in Neurology 0915-162016

64

Clinical applications

bull The o-VEMP is a sensitive test of otolithutricular

function

bull Complements vestibular test procedures that assess

semicircular canals

bull Abnormally robust responses are associated with third

window abnormalities such as semicircular canal

dehiscence

bull Serves as an excellent screening test for semicircular

canal dehiscence

Sixth Annual Intensive Update in Neurology 0915-162016

65

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Sixth Annual Intensive Update in Neurology 0915-162016

66

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Answer 1 References at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

67

Enlarged vestibular aqueduct

bull Axial temporal bone CT showing right temporal bone with enlarged vestibular aqueduct (arrow)

bull Vestibular symptoms accompany progressive sensorineural hearing loss in 4-50 of patients in selected series

Sixth Annual Intensive Update in Neurology 0915-162016

68

Migraine

bull Family or personal history of migraine

bull 25 of migraine patients experience spontaneous vertigo (Baloh 1997)

bull Neuhauser criteria(2001) have been used to construct structured diagnostic interviews (Furman 2003)

bull Not always associated with headache

bull Motion sensitivity

bull Medication responsive

Sixth Annual Intensive Update in Neurology 0915-162016

69

ICHD-III beta Criteria for Vestibular Migraine

bull A At least five attacks fulfilling criteria C and D

bull B A current or past history of 11 migraine without aura or 12 migraine with aura

bull C Vestibular symptoms of moderate or severe intensity lasting between 5 minutes and 72 hours

bull D At least 50 associated with one of the following migrainous features

ndash 1 Headaches

ndash 2 Photophobia and phonophobia

ndash 3 Visual Aura

bull E Not better accounted for by another vestibular disorder

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 44: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

44

Acute Vestibular Syndrome

bull Usually peripheral and can be associated with

hearing loss (labyrinthitis)

bull Timely diagnosis improves recovery (ASAP

prednisone 1mgkgday for ten days and taper 10

mgday ndash Strupp M 2004 NEJM)

bull Avoid vestibular suppressants after 3 days and begin

vestibular rehabilitation to hasten compensation

Sixth Annual Intensive Update in Neurology 0915-162016

45

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

46

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Answer 5 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

47

Menierersquos syndrome

bull Fluctuating low frequency hearing loss

bull Tinnitus andor aural fullness

bull Vertigo lasting hours

Sixth Annual Intensive Update in Neurology 0915-162016

48

Normal

Sixth Annual Intensive Update in Neurology 0915-162016

49

Hydrops

Sixth Annual Intensive Update in Neurology 0915-162016

50

Menierersquos syndrome

ndash Diagnosis- Exclusion (RO acoustic)

ndash 23 of Menierersquos patients will improve spontaneously

ndash Treatment-1500 mgday low sodium triamterene375-

hydrochlorothiazide 25 vestibular suppressants (lorazepam

1 mg tablet sublingual Q 8 prn attacks) off label use

Sixth Annual Intensive Update in Neurology 0915-162016

51

Menierersquos syndrome ndash intratympanic steroids

ndash A newer treatment option for those failing medical management

ndash 90 response rate (Boleus-Aguirre MS Otology Neurotology

2008)

ndash Outcomes data confirm excellent clinical response in 3941

Menierersquos patients treated with intratympanic steroids in 2008

Sixth Annual Intensive Update in Neurology 0915-162016

52

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

53

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Answer 5 See references at end

Sixth Annual Intensive Update in Neurology 0915-162016

54

Superior Semicircular Canal Dehiscence (SSCD)

bull Sound andor pressure induced oscillopsia

bull CT reformatted in the plane of the superior canals

shows dehiscence of overlying bone

bull Low frequency ldquoconductive hyperacusisrdquo with elevated

bone thresholds normal reflexes and a conductive loss

Sixth Annual Intensive Update in Neurology 0915-162016

55

SSCD

bull Positive middle ear pressure or loud sound stimulates ampullofugal endolymph flow -canal activation

bull Eye movements are tonic upwards with ipsilateral intorsion

Sixth Annual Intensive Update in Neurology 0915-162016

56

SSCD

bull Valsalva against a closed glottis or jugular compression causes increased intracranial pressure and ampullopetal endolymph flow -canal inhibition

bull Eye movements are tonic downwards with ipsilateral extorsion

Sixth Annual Intensive Update in Neurology 0915-162016

57

Reconstructed left superior semicircular canal

Sixth Annual Intensive Update in Neurology 0915-162016

58

Sixth Annual Intensive Update in Neurology 0915-162016

59

SCHEMATIC DRAWING OF AN OTOLITHIC MACULA

Sixth Annual Intensive Update in Neurology 0915-162016

60

MACULAE OF THE UTRICLESACCULE

Sixth Annual Intensive Update in Neurology 0915-162016

61

HAIR CELLS

Sixth Annual Intensive Update in Neurology 0915-162016

62

SCANNING ELECTRON MICROGRAPH OF OTOCONIA

Sixth Annual Intensive Update in Neurology 0915-162016

63

Ocular VEMP

bull Response to loud clicks (80-110 dB) or forehead tap (Halmagyi and Curthoys 2003)

bull Contralateral oculomotor nucleus (CN III)

bull Inferior oblique muscle contraction (8 msec) detected by 5sec event triggered averaging

bull Noninverting electrode inferior to eye

bull Inverting below non-inverting electrode

bull Ground to forehead

bull Normal subjects have very low response

Sixth Annual Intensive Update in Neurology 0915-162016

64

Clinical applications

bull The o-VEMP is a sensitive test of otolithutricular

function

bull Complements vestibular test procedures that assess

semicircular canals

bull Abnormally robust responses are associated with third

window abnormalities such as semicircular canal

dehiscence

bull Serves as an excellent screening test for semicircular

canal dehiscence

Sixth Annual Intensive Update in Neurology 0915-162016

65

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Sixth Annual Intensive Update in Neurology 0915-162016

66

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Answer 1 References at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

67

Enlarged vestibular aqueduct

bull Axial temporal bone CT showing right temporal bone with enlarged vestibular aqueduct (arrow)

bull Vestibular symptoms accompany progressive sensorineural hearing loss in 4-50 of patients in selected series

Sixth Annual Intensive Update in Neurology 0915-162016

68

Migraine

bull Family or personal history of migraine

bull 25 of migraine patients experience spontaneous vertigo (Baloh 1997)

bull Neuhauser criteria(2001) have been used to construct structured diagnostic interviews (Furman 2003)

bull Not always associated with headache

bull Motion sensitivity

bull Medication responsive

Sixth Annual Intensive Update in Neurology 0915-162016

69

ICHD-III beta Criteria for Vestibular Migraine

bull A At least five attacks fulfilling criteria C and D

bull B A current or past history of 11 migraine without aura or 12 migraine with aura

bull C Vestibular symptoms of moderate or severe intensity lasting between 5 minutes and 72 hours

bull D At least 50 associated with one of the following migrainous features

ndash 1 Headaches

ndash 2 Photophobia and phonophobia

ndash 3 Visual Aura

bull E Not better accounted for by another vestibular disorder

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 45: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

45

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

46

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Answer 5 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

47

Menierersquos syndrome

bull Fluctuating low frequency hearing loss

bull Tinnitus andor aural fullness

bull Vertigo lasting hours

Sixth Annual Intensive Update in Neurology 0915-162016

48

Normal

Sixth Annual Intensive Update in Neurology 0915-162016

49

Hydrops

Sixth Annual Intensive Update in Neurology 0915-162016

50

Menierersquos syndrome

ndash Diagnosis- Exclusion (RO acoustic)

ndash 23 of Menierersquos patients will improve spontaneously

ndash Treatment-1500 mgday low sodium triamterene375-

hydrochlorothiazide 25 vestibular suppressants (lorazepam

1 mg tablet sublingual Q 8 prn attacks) off label use

Sixth Annual Intensive Update in Neurology 0915-162016

51

Menierersquos syndrome ndash intratympanic steroids

ndash A newer treatment option for those failing medical management

ndash 90 response rate (Boleus-Aguirre MS Otology Neurotology

2008)

ndash Outcomes data confirm excellent clinical response in 3941

Menierersquos patients treated with intratympanic steroids in 2008

Sixth Annual Intensive Update in Neurology 0915-162016

52

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

53

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Answer 5 See references at end

Sixth Annual Intensive Update in Neurology 0915-162016

54

Superior Semicircular Canal Dehiscence (SSCD)

bull Sound andor pressure induced oscillopsia

bull CT reformatted in the plane of the superior canals

shows dehiscence of overlying bone

bull Low frequency ldquoconductive hyperacusisrdquo with elevated

bone thresholds normal reflexes and a conductive loss

Sixth Annual Intensive Update in Neurology 0915-162016

55

SSCD

bull Positive middle ear pressure or loud sound stimulates ampullofugal endolymph flow -canal activation

bull Eye movements are tonic upwards with ipsilateral intorsion

Sixth Annual Intensive Update in Neurology 0915-162016

56

SSCD

bull Valsalva against a closed glottis or jugular compression causes increased intracranial pressure and ampullopetal endolymph flow -canal inhibition

bull Eye movements are tonic downwards with ipsilateral extorsion

Sixth Annual Intensive Update in Neurology 0915-162016

57

Reconstructed left superior semicircular canal

Sixth Annual Intensive Update in Neurology 0915-162016

58

Sixth Annual Intensive Update in Neurology 0915-162016

59

SCHEMATIC DRAWING OF AN OTOLITHIC MACULA

Sixth Annual Intensive Update in Neurology 0915-162016

60

MACULAE OF THE UTRICLESACCULE

Sixth Annual Intensive Update in Neurology 0915-162016

61

HAIR CELLS

Sixth Annual Intensive Update in Neurology 0915-162016

62

SCANNING ELECTRON MICROGRAPH OF OTOCONIA

Sixth Annual Intensive Update in Neurology 0915-162016

63

Ocular VEMP

bull Response to loud clicks (80-110 dB) or forehead tap (Halmagyi and Curthoys 2003)

bull Contralateral oculomotor nucleus (CN III)

bull Inferior oblique muscle contraction (8 msec) detected by 5sec event triggered averaging

bull Noninverting electrode inferior to eye

bull Inverting below non-inverting electrode

bull Ground to forehead

bull Normal subjects have very low response

Sixth Annual Intensive Update in Neurology 0915-162016

64

Clinical applications

bull The o-VEMP is a sensitive test of otolithutricular

function

bull Complements vestibular test procedures that assess

semicircular canals

bull Abnormally robust responses are associated with third

window abnormalities such as semicircular canal

dehiscence

bull Serves as an excellent screening test for semicircular

canal dehiscence

Sixth Annual Intensive Update in Neurology 0915-162016

65

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Sixth Annual Intensive Update in Neurology 0915-162016

66

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Answer 1 References at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

67

Enlarged vestibular aqueduct

bull Axial temporal bone CT showing right temporal bone with enlarged vestibular aqueduct (arrow)

bull Vestibular symptoms accompany progressive sensorineural hearing loss in 4-50 of patients in selected series

Sixth Annual Intensive Update in Neurology 0915-162016

68

Migraine

bull Family or personal history of migraine

bull 25 of migraine patients experience spontaneous vertigo (Baloh 1997)

bull Neuhauser criteria(2001) have been used to construct structured diagnostic interviews (Furman 2003)

bull Not always associated with headache

bull Motion sensitivity

bull Medication responsive

Sixth Annual Intensive Update in Neurology 0915-162016

69

ICHD-III beta Criteria for Vestibular Migraine

bull A At least five attacks fulfilling criteria C and D

bull B A current or past history of 11 migraine without aura or 12 migraine with aura

bull C Vestibular symptoms of moderate or severe intensity lasting between 5 minutes and 72 hours

bull D At least 50 associated with one of the following migrainous features

ndash 1 Headaches

ndash 2 Photophobia and phonophobia

ndash 3 Visual Aura

bull E Not better accounted for by another vestibular disorder

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 46: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

46

Question 3

bull Treatment for Acute Vestibular Syndrome

1) oral prednisone 1 mgkgday

2) Treat dehydration if necessary

3) Minimize vestibular suppressants after 3 days

4) Consider vestibular physical therapy

5) All of the above

Answer 5 See references at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

47

Menierersquos syndrome

bull Fluctuating low frequency hearing loss

bull Tinnitus andor aural fullness

bull Vertigo lasting hours

Sixth Annual Intensive Update in Neurology 0915-162016

48

Normal

Sixth Annual Intensive Update in Neurology 0915-162016

49

Hydrops

Sixth Annual Intensive Update in Neurology 0915-162016

50

Menierersquos syndrome

ndash Diagnosis- Exclusion (RO acoustic)

ndash 23 of Menierersquos patients will improve spontaneously

ndash Treatment-1500 mgday low sodium triamterene375-

hydrochlorothiazide 25 vestibular suppressants (lorazepam

1 mg tablet sublingual Q 8 prn attacks) off label use

Sixth Annual Intensive Update in Neurology 0915-162016

51

Menierersquos syndrome ndash intratympanic steroids

ndash A newer treatment option for those failing medical management

ndash 90 response rate (Boleus-Aguirre MS Otology Neurotology

2008)

ndash Outcomes data confirm excellent clinical response in 3941

Menierersquos patients treated with intratympanic steroids in 2008

Sixth Annual Intensive Update in Neurology 0915-162016

52

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

53

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Answer 5 See references at end

Sixth Annual Intensive Update in Neurology 0915-162016

54

Superior Semicircular Canal Dehiscence (SSCD)

bull Sound andor pressure induced oscillopsia

bull CT reformatted in the plane of the superior canals

shows dehiscence of overlying bone

bull Low frequency ldquoconductive hyperacusisrdquo with elevated

bone thresholds normal reflexes and a conductive loss

Sixth Annual Intensive Update in Neurology 0915-162016

55

SSCD

bull Positive middle ear pressure or loud sound stimulates ampullofugal endolymph flow -canal activation

bull Eye movements are tonic upwards with ipsilateral intorsion

Sixth Annual Intensive Update in Neurology 0915-162016

56

SSCD

bull Valsalva against a closed glottis or jugular compression causes increased intracranial pressure and ampullopetal endolymph flow -canal inhibition

bull Eye movements are tonic downwards with ipsilateral extorsion

Sixth Annual Intensive Update in Neurology 0915-162016

57

Reconstructed left superior semicircular canal

Sixth Annual Intensive Update in Neurology 0915-162016

58

Sixth Annual Intensive Update in Neurology 0915-162016

59

SCHEMATIC DRAWING OF AN OTOLITHIC MACULA

Sixth Annual Intensive Update in Neurology 0915-162016

60

MACULAE OF THE UTRICLESACCULE

Sixth Annual Intensive Update in Neurology 0915-162016

61

HAIR CELLS

Sixth Annual Intensive Update in Neurology 0915-162016

62

SCANNING ELECTRON MICROGRAPH OF OTOCONIA

Sixth Annual Intensive Update in Neurology 0915-162016

63

Ocular VEMP

bull Response to loud clicks (80-110 dB) or forehead tap (Halmagyi and Curthoys 2003)

bull Contralateral oculomotor nucleus (CN III)

bull Inferior oblique muscle contraction (8 msec) detected by 5sec event triggered averaging

bull Noninverting electrode inferior to eye

bull Inverting below non-inverting electrode

bull Ground to forehead

bull Normal subjects have very low response

Sixth Annual Intensive Update in Neurology 0915-162016

64

Clinical applications

bull The o-VEMP is a sensitive test of otolithutricular

function

bull Complements vestibular test procedures that assess

semicircular canals

bull Abnormally robust responses are associated with third

window abnormalities such as semicircular canal

dehiscence

bull Serves as an excellent screening test for semicircular

canal dehiscence

Sixth Annual Intensive Update in Neurology 0915-162016

65

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Sixth Annual Intensive Update in Neurology 0915-162016

66

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Answer 1 References at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

67

Enlarged vestibular aqueduct

bull Axial temporal bone CT showing right temporal bone with enlarged vestibular aqueduct (arrow)

bull Vestibular symptoms accompany progressive sensorineural hearing loss in 4-50 of patients in selected series

Sixth Annual Intensive Update in Neurology 0915-162016

68

Migraine

bull Family or personal history of migraine

bull 25 of migraine patients experience spontaneous vertigo (Baloh 1997)

bull Neuhauser criteria(2001) have been used to construct structured diagnostic interviews (Furman 2003)

bull Not always associated with headache

bull Motion sensitivity

bull Medication responsive

Sixth Annual Intensive Update in Neurology 0915-162016

69

ICHD-III beta Criteria for Vestibular Migraine

bull A At least five attacks fulfilling criteria C and D

bull B A current or past history of 11 migraine without aura or 12 migraine with aura

bull C Vestibular symptoms of moderate or severe intensity lasting between 5 minutes and 72 hours

bull D At least 50 associated with one of the following migrainous features

ndash 1 Headaches

ndash 2 Photophobia and phonophobia

ndash 3 Visual Aura

bull E Not better accounted for by another vestibular disorder

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 47: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

47

Menierersquos syndrome

bull Fluctuating low frequency hearing loss

bull Tinnitus andor aural fullness

bull Vertigo lasting hours

Sixth Annual Intensive Update in Neurology 0915-162016

48

Normal

Sixth Annual Intensive Update in Neurology 0915-162016

49

Hydrops

Sixth Annual Intensive Update in Neurology 0915-162016

50

Menierersquos syndrome

ndash Diagnosis- Exclusion (RO acoustic)

ndash 23 of Menierersquos patients will improve spontaneously

ndash Treatment-1500 mgday low sodium triamterene375-

hydrochlorothiazide 25 vestibular suppressants (lorazepam

1 mg tablet sublingual Q 8 prn attacks) off label use

Sixth Annual Intensive Update in Neurology 0915-162016

51

Menierersquos syndrome ndash intratympanic steroids

ndash A newer treatment option for those failing medical management

ndash 90 response rate (Boleus-Aguirre MS Otology Neurotology

2008)

ndash Outcomes data confirm excellent clinical response in 3941

Menierersquos patients treated with intratympanic steroids in 2008

Sixth Annual Intensive Update in Neurology 0915-162016

52

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

53

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Answer 5 See references at end

Sixth Annual Intensive Update in Neurology 0915-162016

54

Superior Semicircular Canal Dehiscence (SSCD)

bull Sound andor pressure induced oscillopsia

bull CT reformatted in the plane of the superior canals

shows dehiscence of overlying bone

bull Low frequency ldquoconductive hyperacusisrdquo with elevated

bone thresholds normal reflexes and a conductive loss

Sixth Annual Intensive Update in Neurology 0915-162016

55

SSCD

bull Positive middle ear pressure or loud sound stimulates ampullofugal endolymph flow -canal activation

bull Eye movements are tonic upwards with ipsilateral intorsion

Sixth Annual Intensive Update in Neurology 0915-162016

56

SSCD

bull Valsalva against a closed glottis or jugular compression causes increased intracranial pressure and ampullopetal endolymph flow -canal inhibition

bull Eye movements are tonic downwards with ipsilateral extorsion

Sixth Annual Intensive Update in Neurology 0915-162016

57

Reconstructed left superior semicircular canal

Sixth Annual Intensive Update in Neurology 0915-162016

58

Sixth Annual Intensive Update in Neurology 0915-162016

59

SCHEMATIC DRAWING OF AN OTOLITHIC MACULA

Sixth Annual Intensive Update in Neurology 0915-162016

60

MACULAE OF THE UTRICLESACCULE

Sixth Annual Intensive Update in Neurology 0915-162016

61

HAIR CELLS

Sixth Annual Intensive Update in Neurology 0915-162016

62

SCANNING ELECTRON MICROGRAPH OF OTOCONIA

Sixth Annual Intensive Update in Neurology 0915-162016

63

Ocular VEMP

bull Response to loud clicks (80-110 dB) or forehead tap (Halmagyi and Curthoys 2003)

bull Contralateral oculomotor nucleus (CN III)

bull Inferior oblique muscle contraction (8 msec) detected by 5sec event triggered averaging

bull Noninverting electrode inferior to eye

bull Inverting below non-inverting electrode

bull Ground to forehead

bull Normal subjects have very low response

Sixth Annual Intensive Update in Neurology 0915-162016

64

Clinical applications

bull The o-VEMP is a sensitive test of otolithutricular

function

bull Complements vestibular test procedures that assess

semicircular canals

bull Abnormally robust responses are associated with third

window abnormalities such as semicircular canal

dehiscence

bull Serves as an excellent screening test for semicircular

canal dehiscence

Sixth Annual Intensive Update in Neurology 0915-162016

65

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Sixth Annual Intensive Update in Neurology 0915-162016

66

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Answer 1 References at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

67

Enlarged vestibular aqueduct

bull Axial temporal bone CT showing right temporal bone with enlarged vestibular aqueduct (arrow)

bull Vestibular symptoms accompany progressive sensorineural hearing loss in 4-50 of patients in selected series

Sixth Annual Intensive Update in Neurology 0915-162016

68

Migraine

bull Family or personal history of migraine

bull 25 of migraine patients experience spontaneous vertigo (Baloh 1997)

bull Neuhauser criteria(2001) have been used to construct structured diagnostic interviews (Furman 2003)

bull Not always associated with headache

bull Motion sensitivity

bull Medication responsive

Sixth Annual Intensive Update in Neurology 0915-162016

69

ICHD-III beta Criteria for Vestibular Migraine

bull A At least five attacks fulfilling criteria C and D

bull B A current or past history of 11 migraine without aura or 12 migraine with aura

bull C Vestibular symptoms of moderate or severe intensity lasting between 5 minutes and 72 hours

bull D At least 50 associated with one of the following migrainous features

ndash 1 Headaches

ndash 2 Photophobia and phonophobia

ndash 3 Visual Aura

bull E Not better accounted for by another vestibular disorder

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 48: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

48

Normal

Sixth Annual Intensive Update in Neurology 0915-162016

49

Hydrops

Sixth Annual Intensive Update in Neurology 0915-162016

50

Menierersquos syndrome

ndash Diagnosis- Exclusion (RO acoustic)

ndash 23 of Menierersquos patients will improve spontaneously

ndash Treatment-1500 mgday low sodium triamterene375-

hydrochlorothiazide 25 vestibular suppressants (lorazepam

1 mg tablet sublingual Q 8 prn attacks) off label use

Sixth Annual Intensive Update in Neurology 0915-162016

51

Menierersquos syndrome ndash intratympanic steroids

ndash A newer treatment option for those failing medical management

ndash 90 response rate (Boleus-Aguirre MS Otology Neurotology

2008)

ndash Outcomes data confirm excellent clinical response in 3941

Menierersquos patients treated with intratympanic steroids in 2008

Sixth Annual Intensive Update in Neurology 0915-162016

52

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

53

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Answer 5 See references at end

Sixth Annual Intensive Update in Neurology 0915-162016

54

Superior Semicircular Canal Dehiscence (SSCD)

bull Sound andor pressure induced oscillopsia

bull CT reformatted in the plane of the superior canals

shows dehiscence of overlying bone

bull Low frequency ldquoconductive hyperacusisrdquo with elevated

bone thresholds normal reflexes and a conductive loss

Sixth Annual Intensive Update in Neurology 0915-162016

55

SSCD

bull Positive middle ear pressure or loud sound stimulates ampullofugal endolymph flow -canal activation

bull Eye movements are tonic upwards with ipsilateral intorsion

Sixth Annual Intensive Update in Neurology 0915-162016

56

SSCD

bull Valsalva against a closed glottis or jugular compression causes increased intracranial pressure and ampullopetal endolymph flow -canal inhibition

bull Eye movements are tonic downwards with ipsilateral extorsion

Sixth Annual Intensive Update in Neurology 0915-162016

57

Reconstructed left superior semicircular canal

Sixth Annual Intensive Update in Neurology 0915-162016

58

Sixth Annual Intensive Update in Neurology 0915-162016

59

SCHEMATIC DRAWING OF AN OTOLITHIC MACULA

Sixth Annual Intensive Update in Neurology 0915-162016

60

MACULAE OF THE UTRICLESACCULE

Sixth Annual Intensive Update in Neurology 0915-162016

61

HAIR CELLS

Sixth Annual Intensive Update in Neurology 0915-162016

62

SCANNING ELECTRON MICROGRAPH OF OTOCONIA

Sixth Annual Intensive Update in Neurology 0915-162016

63

Ocular VEMP

bull Response to loud clicks (80-110 dB) or forehead tap (Halmagyi and Curthoys 2003)

bull Contralateral oculomotor nucleus (CN III)

bull Inferior oblique muscle contraction (8 msec) detected by 5sec event triggered averaging

bull Noninverting electrode inferior to eye

bull Inverting below non-inverting electrode

bull Ground to forehead

bull Normal subjects have very low response

Sixth Annual Intensive Update in Neurology 0915-162016

64

Clinical applications

bull The o-VEMP is a sensitive test of otolithutricular

function

bull Complements vestibular test procedures that assess

semicircular canals

bull Abnormally robust responses are associated with third

window abnormalities such as semicircular canal

dehiscence

bull Serves as an excellent screening test for semicircular

canal dehiscence

Sixth Annual Intensive Update in Neurology 0915-162016

65

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Sixth Annual Intensive Update in Neurology 0915-162016

66

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Answer 1 References at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

67

Enlarged vestibular aqueduct

bull Axial temporal bone CT showing right temporal bone with enlarged vestibular aqueduct (arrow)

bull Vestibular symptoms accompany progressive sensorineural hearing loss in 4-50 of patients in selected series

Sixth Annual Intensive Update in Neurology 0915-162016

68

Migraine

bull Family or personal history of migraine

bull 25 of migraine patients experience spontaneous vertigo (Baloh 1997)

bull Neuhauser criteria(2001) have been used to construct structured diagnostic interviews (Furman 2003)

bull Not always associated with headache

bull Motion sensitivity

bull Medication responsive

Sixth Annual Intensive Update in Neurology 0915-162016

69

ICHD-III beta Criteria for Vestibular Migraine

bull A At least five attacks fulfilling criteria C and D

bull B A current or past history of 11 migraine without aura or 12 migraine with aura

bull C Vestibular symptoms of moderate or severe intensity lasting between 5 minutes and 72 hours

bull D At least 50 associated with one of the following migrainous features

ndash 1 Headaches

ndash 2 Photophobia and phonophobia

ndash 3 Visual Aura

bull E Not better accounted for by another vestibular disorder

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 49: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

49

Hydrops

Sixth Annual Intensive Update in Neurology 0915-162016

50

Menierersquos syndrome

ndash Diagnosis- Exclusion (RO acoustic)

ndash 23 of Menierersquos patients will improve spontaneously

ndash Treatment-1500 mgday low sodium triamterene375-

hydrochlorothiazide 25 vestibular suppressants (lorazepam

1 mg tablet sublingual Q 8 prn attacks) off label use

Sixth Annual Intensive Update in Neurology 0915-162016

51

Menierersquos syndrome ndash intratympanic steroids

ndash A newer treatment option for those failing medical management

ndash 90 response rate (Boleus-Aguirre MS Otology Neurotology

2008)

ndash Outcomes data confirm excellent clinical response in 3941

Menierersquos patients treated with intratympanic steroids in 2008

Sixth Annual Intensive Update in Neurology 0915-162016

52

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

53

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Answer 5 See references at end

Sixth Annual Intensive Update in Neurology 0915-162016

54

Superior Semicircular Canal Dehiscence (SSCD)

bull Sound andor pressure induced oscillopsia

bull CT reformatted in the plane of the superior canals

shows dehiscence of overlying bone

bull Low frequency ldquoconductive hyperacusisrdquo with elevated

bone thresholds normal reflexes and a conductive loss

Sixth Annual Intensive Update in Neurology 0915-162016

55

SSCD

bull Positive middle ear pressure or loud sound stimulates ampullofugal endolymph flow -canal activation

bull Eye movements are tonic upwards with ipsilateral intorsion

Sixth Annual Intensive Update in Neurology 0915-162016

56

SSCD

bull Valsalva against a closed glottis or jugular compression causes increased intracranial pressure and ampullopetal endolymph flow -canal inhibition

bull Eye movements are tonic downwards with ipsilateral extorsion

Sixth Annual Intensive Update in Neurology 0915-162016

57

Reconstructed left superior semicircular canal

Sixth Annual Intensive Update in Neurology 0915-162016

58

Sixth Annual Intensive Update in Neurology 0915-162016

59

SCHEMATIC DRAWING OF AN OTOLITHIC MACULA

Sixth Annual Intensive Update in Neurology 0915-162016

60

MACULAE OF THE UTRICLESACCULE

Sixth Annual Intensive Update in Neurology 0915-162016

61

HAIR CELLS

Sixth Annual Intensive Update in Neurology 0915-162016

62

SCANNING ELECTRON MICROGRAPH OF OTOCONIA

Sixth Annual Intensive Update in Neurology 0915-162016

63

Ocular VEMP

bull Response to loud clicks (80-110 dB) or forehead tap (Halmagyi and Curthoys 2003)

bull Contralateral oculomotor nucleus (CN III)

bull Inferior oblique muscle contraction (8 msec) detected by 5sec event triggered averaging

bull Noninverting electrode inferior to eye

bull Inverting below non-inverting electrode

bull Ground to forehead

bull Normal subjects have very low response

Sixth Annual Intensive Update in Neurology 0915-162016

64

Clinical applications

bull The o-VEMP is a sensitive test of otolithutricular

function

bull Complements vestibular test procedures that assess

semicircular canals

bull Abnormally robust responses are associated with third

window abnormalities such as semicircular canal

dehiscence

bull Serves as an excellent screening test for semicircular

canal dehiscence

Sixth Annual Intensive Update in Neurology 0915-162016

65

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Sixth Annual Intensive Update in Neurology 0915-162016

66

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Answer 1 References at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

67

Enlarged vestibular aqueduct

bull Axial temporal bone CT showing right temporal bone with enlarged vestibular aqueduct (arrow)

bull Vestibular symptoms accompany progressive sensorineural hearing loss in 4-50 of patients in selected series

Sixth Annual Intensive Update in Neurology 0915-162016

68

Migraine

bull Family or personal history of migraine

bull 25 of migraine patients experience spontaneous vertigo (Baloh 1997)

bull Neuhauser criteria(2001) have been used to construct structured diagnostic interviews (Furman 2003)

bull Not always associated with headache

bull Motion sensitivity

bull Medication responsive

Sixth Annual Intensive Update in Neurology 0915-162016

69

ICHD-III beta Criteria for Vestibular Migraine

bull A At least five attacks fulfilling criteria C and D

bull B A current or past history of 11 migraine without aura or 12 migraine with aura

bull C Vestibular symptoms of moderate or severe intensity lasting between 5 minutes and 72 hours

bull D At least 50 associated with one of the following migrainous features

ndash 1 Headaches

ndash 2 Photophobia and phonophobia

ndash 3 Visual Aura

bull E Not better accounted for by another vestibular disorder

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 50: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

50

Menierersquos syndrome

ndash Diagnosis- Exclusion (RO acoustic)

ndash 23 of Menierersquos patients will improve spontaneously

ndash Treatment-1500 mgday low sodium triamterene375-

hydrochlorothiazide 25 vestibular suppressants (lorazepam

1 mg tablet sublingual Q 8 prn attacks) off label use

Sixth Annual Intensive Update in Neurology 0915-162016

51

Menierersquos syndrome ndash intratympanic steroids

ndash A newer treatment option for those failing medical management

ndash 90 response rate (Boleus-Aguirre MS Otology Neurotology

2008)

ndash Outcomes data confirm excellent clinical response in 3941

Menierersquos patients treated with intratympanic steroids in 2008

Sixth Annual Intensive Update in Neurology 0915-162016

52

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

53

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Answer 5 See references at end

Sixth Annual Intensive Update in Neurology 0915-162016

54

Superior Semicircular Canal Dehiscence (SSCD)

bull Sound andor pressure induced oscillopsia

bull CT reformatted in the plane of the superior canals

shows dehiscence of overlying bone

bull Low frequency ldquoconductive hyperacusisrdquo with elevated

bone thresholds normal reflexes and a conductive loss

Sixth Annual Intensive Update in Neurology 0915-162016

55

SSCD

bull Positive middle ear pressure or loud sound stimulates ampullofugal endolymph flow -canal activation

bull Eye movements are tonic upwards with ipsilateral intorsion

Sixth Annual Intensive Update in Neurology 0915-162016

56

SSCD

bull Valsalva against a closed glottis or jugular compression causes increased intracranial pressure and ampullopetal endolymph flow -canal inhibition

bull Eye movements are tonic downwards with ipsilateral extorsion

Sixth Annual Intensive Update in Neurology 0915-162016

57

Reconstructed left superior semicircular canal

Sixth Annual Intensive Update in Neurology 0915-162016

58

Sixth Annual Intensive Update in Neurology 0915-162016

59

SCHEMATIC DRAWING OF AN OTOLITHIC MACULA

Sixth Annual Intensive Update in Neurology 0915-162016

60

MACULAE OF THE UTRICLESACCULE

Sixth Annual Intensive Update in Neurology 0915-162016

61

HAIR CELLS

Sixth Annual Intensive Update in Neurology 0915-162016

62

SCANNING ELECTRON MICROGRAPH OF OTOCONIA

Sixth Annual Intensive Update in Neurology 0915-162016

63

Ocular VEMP

bull Response to loud clicks (80-110 dB) or forehead tap (Halmagyi and Curthoys 2003)

bull Contralateral oculomotor nucleus (CN III)

bull Inferior oblique muscle contraction (8 msec) detected by 5sec event triggered averaging

bull Noninverting electrode inferior to eye

bull Inverting below non-inverting electrode

bull Ground to forehead

bull Normal subjects have very low response

Sixth Annual Intensive Update in Neurology 0915-162016

64

Clinical applications

bull The o-VEMP is a sensitive test of otolithutricular

function

bull Complements vestibular test procedures that assess

semicircular canals

bull Abnormally robust responses are associated with third

window abnormalities such as semicircular canal

dehiscence

bull Serves as an excellent screening test for semicircular

canal dehiscence

Sixth Annual Intensive Update in Neurology 0915-162016

65

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Sixth Annual Intensive Update in Neurology 0915-162016

66

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Answer 1 References at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

67

Enlarged vestibular aqueduct

bull Axial temporal bone CT showing right temporal bone with enlarged vestibular aqueduct (arrow)

bull Vestibular symptoms accompany progressive sensorineural hearing loss in 4-50 of patients in selected series

Sixth Annual Intensive Update in Neurology 0915-162016

68

Migraine

bull Family or personal history of migraine

bull 25 of migraine patients experience spontaneous vertigo (Baloh 1997)

bull Neuhauser criteria(2001) have been used to construct structured diagnostic interviews (Furman 2003)

bull Not always associated with headache

bull Motion sensitivity

bull Medication responsive

Sixth Annual Intensive Update in Neurology 0915-162016

69

ICHD-III beta Criteria for Vestibular Migraine

bull A At least five attacks fulfilling criteria C and D

bull B A current or past history of 11 migraine without aura or 12 migraine with aura

bull C Vestibular symptoms of moderate or severe intensity lasting between 5 minutes and 72 hours

bull D At least 50 associated with one of the following migrainous features

ndash 1 Headaches

ndash 2 Photophobia and phonophobia

ndash 3 Visual Aura

bull E Not better accounted for by another vestibular disorder

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 51: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

51

Menierersquos syndrome ndash intratympanic steroids

ndash A newer treatment option for those failing medical management

ndash 90 response rate (Boleus-Aguirre MS Otology Neurotology

2008)

ndash Outcomes data confirm excellent clinical response in 3941

Menierersquos patients treated with intratympanic steroids in 2008

Sixth Annual Intensive Update in Neurology 0915-162016

52

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

53

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Answer 5 See references at end

Sixth Annual Intensive Update in Neurology 0915-162016

54

Superior Semicircular Canal Dehiscence (SSCD)

bull Sound andor pressure induced oscillopsia

bull CT reformatted in the plane of the superior canals

shows dehiscence of overlying bone

bull Low frequency ldquoconductive hyperacusisrdquo with elevated

bone thresholds normal reflexes and a conductive loss

Sixth Annual Intensive Update in Neurology 0915-162016

55

SSCD

bull Positive middle ear pressure or loud sound stimulates ampullofugal endolymph flow -canal activation

bull Eye movements are tonic upwards with ipsilateral intorsion

Sixth Annual Intensive Update in Neurology 0915-162016

56

SSCD

bull Valsalva against a closed glottis or jugular compression causes increased intracranial pressure and ampullopetal endolymph flow -canal inhibition

bull Eye movements are tonic downwards with ipsilateral extorsion

Sixth Annual Intensive Update in Neurology 0915-162016

57

Reconstructed left superior semicircular canal

Sixth Annual Intensive Update in Neurology 0915-162016

58

Sixth Annual Intensive Update in Neurology 0915-162016

59

SCHEMATIC DRAWING OF AN OTOLITHIC MACULA

Sixth Annual Intensive Update in Neurology 0915-162016

60

MACULAE OF THE UTRICLESACCULE

Sixth Annual Intensive Update in Neurology 0915-162016

61

HAIR CELLS

Sixth Annual Intensive Update in Neurology 0915-162016

62

SCANNING ELECTRON MICROGRAPH OF OTOCONIA

Sixth Annual Intensive Update in Neurology 0915-162016

63

Ocular VEMP

bull Response to loud clicks (80-110 dB) or forehead tap (Halmagyi and Curthoys 2003)

bull Contralateral oculomotor nucleus (CN III)

bull Inferior oblique muscle contraction (8 msec) detected by 5sec event triggered averaging

bull Noninverting electrode inferior to eye

bull Inverting below non-inverting electrode

bull Ground to forehead

bull Normal subjects have very low response

Sixth Annual Intensive Update in Neurology 0915-162016

64

Clinical applications

bull The o-VEMP is a sensitive test of otolithutricular

function

bull Complements vestibular test procedures that assess

semicircular canals

bull Abnormally robust responses are associated with third

window abnormalities such as semicircular canal

dehiscence

bull Serves as an excellent screening test for semicircular

canal dehiscence

Sixth Annual Intensive Update in Neurology 0915-162016

65

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Sixth Annual Intensive Update in Neurology 0915-162016

66

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Answer 1 References at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

67

Enlarged vestibular aqueduct

bull Axial temporal bone CT showing right temporal bone with enlarged vestibular aqueduct (arrow)

bull Vestibular symptoms accompany progressive sensorineural hearing loss in 4-50 of patients in selected series

Sixth Annual Intensive Update in Neurology 0915-162016

68

Migraine

bull Family or personal history of migraine

bull 25 of migraine patients experience spontaneous vertigo (Baloh 1997)

bull Neuhauser criteria(2001) have been used to construct structured diagnostic interviews (Furman 2003)

bull Not always associated with headache

bull Motion sensitivity

bull Medication responsive

Sixth Annual Intensive Update in Neurology 0915-162016

69

ICHD-III beta Criteria for Vestibular Migraine

bull A At least five attacks fulfilling criteria C and D

bull B A current or past history of 11 migraine without aura or 12 migraine with aura

bull C Vestibular symptoms of moderate or severe intensity lasting between 5 minutes and 72 hours

bull D At least 50 associated with one of the following migrainous features

ndash 1 Headaches

ndash 2 Photophobia and phonophobia

ndash 3 Visual Aura

bull E Not better accounted for by another vestibular disorder

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 52: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

52

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Sixth Annual Intensive Update in Neurology 0915-162016

53

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Answer 5 See references at end

Sixth Annual Intensive Update in Neurology 0915-162016

54

Superior Semicircular Canal Dehiscence (SSCD)

bull Sound andor pressure induced oscillopsia

bull CT reformatted in the plane of the superior canals

shows dehiscence of overlying bone

bull Low frequency ldquoconductive hyperacusisrdquo with elevated

bone thresholds normal reflexes and a conductive loss

Sixth Annual Intensive Update in Neurology 0915-162016

55

SSCD

bull Positive middle ear pressure or loud sound stimulates ampullofugal endolymph flow -canal activation

bull Eye movements are tonic upwards with ipsilateral intorsion

Sixth Annual Intensive Update in Neurology 0915-162016

56

SSCD

bull Valsalva against a closed glottis or jugular compression causes increased intracranial pressure and ampullopetal endolymph flow -canal inhibition

bull Eye movements are tonic downwards with ipsilateral extorsion

Sixth Annual Intensive Update in Neurology 0915-162016

57

Reconstructed left superior semicircular canal

Sixth Annual Intensive Update in Neurology 0915-162016

58

Sixth Annual Intensive Update in Neurology 0915-162016

59

SCHEMATIC DRAWING OF AN OTOLITHIC MACULA

Sixth Annual Intensive Update in Neurology 0915-162016

60

MACULAE OF THE UTRICLESACCULE

Sixth Annual Intensive Update in Neurology 0915-162016

61

HAIR CELLS

Sixth Annual Intensive Update in Neurology 0915-162016

62

SCANNING ELECTRON MICROGRAPH OF OTOCONIA

Sixth Annual Intensive Update in Neurology 0915-162016

63

Ocular VEMP

bull Response to loud clicks (80-110 dB) or forehead tap (Halmagyi and Curthoys 2003)

bull Contralateral oculomotor nucleus (CN III)

bull Inferior oblique muscle contraction (8 msec) detected by 5sec event triggered averaging

bull Noninverting electrode inferior to eye

bull Inverting below non-inverting electrode

bull Ground to forehead

bull Normal subjects have very low response

Sixth Annual Intensive Update in Neurology 0915-162016

64

Clinical applications

bull The o-VEMP is a sensitive test of otolithutricular

function

bull Complements vestibular test procedures that assess

semicircular canals

bull Abnormally robust responses are associated with third

window abnormalities such as semicircular canal

dehiscence

bull Serves as an excellent screening test for semicircular

canal dehiscence

Sixth Annual Intensive Update in Neurology 0915-162016

65

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Sixth Annual Intensive Update in Neurology 0915-162016

66

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Answer 1 References at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

67

Enlarged vestibular aqueduct

bull Axial temporal bone CT showing right temporal bone with enlarged vestibular aqueduct (arrow)

bull Vestibular symptoms accompany progressive sensorineural hearing loss in 4-50 of patients in selected series

Sixth Annual Intensive Update in Neurology 0915-162016

68

Migraine

bull Family or personal history of migraine

bull 25 of migraine patients experience spontaneous vertigo (Baloh 1997)

bull Neuhauser criteria(2001) have been used to construct structured diagnostic interviews (Furman 2003)

bull Not always associated with headache

bull Motion sensitivity

bull Medication responsive

Sixth Annual Intensive Update in Neurology 0915-162016

69

ICHD-III beta Criteria for Vestibular Migraine

bull A At least five attacks fulfilling criteria C and D

bull B A current or past history of 11 migraine without aura or 12 migraine with aura

bull C Vestibular symptoms of moderate or severe intensity lasting between 5 minutes and 72 hours

bull D At least 50 associated with one of the following migrainous features

ndash 1 Headaches

ndash 2 Photophobia and phonophobia

ndash 3 Visual Aura

bull E Not better accounted for by another vestibular disorder

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 53: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

53

Question 4

bull Menierersquos syndrome diagnosis is based on

1) Recurrent vertigo lasting at least 20 minutes

2) Aural fullness

3) Documented hearing loss

4) Other causes excluded

5) All of the above

Answer 5 See references at end

Sixth Annual Intensive Update in Neurology 0915-162016

54

Superior Semicircular Canal Dehiscence (SSCD)

bull Sound andor pressure induced oscillopsia

bull CT reformatted in the plane of the superior canals

shows dehiscence of overlying bone

bull Low frequency ldquoconductive hyperacusisrdquo with elevated

bone thresholds normal reflexes and a conductive loss

Sixth Annual Intensive Update in Neurology 0915-162016

55

SSCD

bull Positive middle ear pressure or loud sound stimulates ampullofugal endolymph flow -canal activation

bull Eye movements are tonic upwards with ipsilateral intorsion

Sixth Annual Intensive Update in Neurology 0915-162016

56

SSCD

bull Valsalva against a closed glottis or jugular compression causes increased intracranial pressure and ampullopetal endolymph flow -canal inhibition

bull Eye movements are tonic downwards with ipsilateral extorsion

Sixth Annual Intensive Update in Neurology 0915-162016

57

Reconstructed left superior semicircular canal

Sixth Annual Intensive Update in Neurology 0915-162016

58

Sixth Annual Intensive Update in Neurology 0915-162016

59

SCHEMATIC DRAWING OF AN OTOLITHIC MACULA

Sixth Annual Intensive Update in Neurology 0915-162016

60

MACULAE OF THE UTRICLESACCULE

Sixth Annual Intensive Update in Neurology 0915-162016

61

HAIR CELLS

Sixth Annual Intensive Update in Neurology 0915-162016

62

SCANNING ELECTRON MICROGRAPH OF OTOCONIA

Sixth Annual Intensive Update in Neurology 0915-162016

63

Ocular VEMP

bull Response to loud clicks (80-110 dB) or forehead tap (Halmagyi and Curthoys 2003)

bull Contralateral oculomotor nucleus (CN III)

bull Inferior oblique muscle contraction (8 msec) detected by 5sec event triggered averaging

bull Noninverting electrode inferior to eye

bull Inverting below non-inverting electrode

bull Ground to forehead

bull Normal subjects have very low response

Sixth Annual Intensive Update in Neurology 0915-162016

64

Clinical applications

bull The o-VEMP is a sensitive test of otolithutricular

function

bull Complements vestibular test procedures that assess

semicircular canals

bull Abnormally robust responses are associated with third

window abnormalities such as semicircular canal

dehiscence

bull Serves as an excellent screening test for semicircular

canal dehiscence

Sixth Annual Intensive Update in Neurology 0915-162016

65

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Sixth Annual Intensive Update in Neurology 0915-162016

66

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Answer 1 References at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

67

Enlarged vestibular aqueduct

bull Axial temporal bone CT showing right temporal bone with enlarged vestibular aqueduct (arrow)

bull Vestibular symptoms accompany progressive sensorineural hearing loss in 4-50 of patients in selected series

Sixth Annual Intensive Update in Neurology 0915-162016

68

Migraine

bull Family or personal history of migraine

bull 25 of migraine patients experience spontaneous vertigo (Baloh 1997)

bull Neuhauser criteria(2001) have been used to construct structured diagnostic interviews (Furman 2003)

bull Not always associated with headache

bull Motion sensitivity

bull Medication responsive

Sixth Annual Intensive Update in Neurology 0915-162016

69

ICHD-III beta Criteria for Vestibular Migraine

bull A At least five attacks fulfilling criteria C and D

bull B A current or past history of 11 migraine without aura or 12 migraine with aura

bull C Vestibular symptoms of moderate or severe intensity lasting between 5 minutes and 72 hours

bull D At least 50 associated with one of the following migrainous features

ndash 1 Headaches

ndash 2 Photophobia and phonophobia

ndash 3 Visual Aura

bull E Not better accounted for by another vestibular disorder

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 54: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

54

Superior Semicircular Canal Dehiscence (SSCD)

bull Sound andor pressure induced oscillopsia

bull CT reformatted in the plane of the superior canals

shows dehiscence of overlying bone

bull Low frequency ldquoconductive hyperacusisrdquo with elevated

bone thresholds normal reflexes and a conductive loss

Sixth Annual Intensive Update in Neurology 0915-162016

55

SSCD

bull Positive middle ear pressure or loud sound stimulates ampullofugal endolymph flow -canal activation

bull Eye movements are tonic upwards with ipsilateral intorsion

Sixth Annual Intensive Update in Neurology 0915-162016

56

SSCD

bull Valsalva against a closed glottis or jugular compression causes increased intracranial pressure and ampullopetal endolymph flow -canal inhibition

bull Eye movements are tonic downwards with ipsilateral extorsion

Sixth Annual Intensive Update in Neurology 0915-162016

57

Reconstructed left superior semicircular canal

Sixth Annual Intensive Update in Neurology 0915-162016

58

Sixth Annual Intensive Update in Neurology 0915-162016

59

SCHEMATIC DRAWING OF AN OTOLITHIC MACULA

Sixth Annual Intensive Update in Neurology 0915-162016

60

MACULAE OF THE UTRICLESACCULE

Sixth Annual Intensive Update in Neurology 0915-162016

61

HAIR CELLS

Sixth Annual Intensive Update in Neurology 0915-162016

62

SCANNING ELECTRON MICROGRAPH OF OTOCONIA

Sixth Annual Intensive Update in Neurology 0915-162016

63

Ocular VEMP

bull Response to loud clicks (80-110 dB) or forehead tap (Halmagyi and Curthoys 2003)

bull Contralateral oculomotor nucleus (CN III)

bull Inferior oblique muscle contraction (8 msec) detected by 5sec event triggered averaging

bull Noninverting electrode inferior to eye

bull Inverting below non-inverting electrode

bull Ground to forehead

bull Normal subjects have very low response

Sixth Annual Intensive Update in Neurology 0915-162016

64

Clinical applications

bull The o-VEMP is a sensitive test of otolithutricular

function

bull Complements vestibular test procedures that assess

semicircular canals

bull Abnormally robust responses are associated with third

window abnormalities such as semicircular canal

dehiscence

bull Serves as an excellent screening test for semicircular

canal dehiscence

Sixth Annual Intensive Update in Neurology 0915-162016

65

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Sixth Annual Intensive Update in Neurology 0915-162016

66

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Answer 1 References at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

67

Enlarged vestibular aqueduct

bull Axial temporal bone CT showing right temporal bone with enlarged vestibular aqueduct (arrow)

bull Vestibular symptoms accompany progressive sensorineural hearing loss in 4-50 of patients in selected series

Sixth Annual Intensive Update in Neurology 0915-162016

68

Migraine

bull Family or personal history of migraine

bull 25 of migraine patients experience spontaneous vertigo (Baloh 1997)

bull Neuhauser criteria(2001) have been used to construct structured diagnostic interviews (Furman 2003)

bull Not always associated with headache

bull Motion sensitivity

bull Medication responsive

Sixth Annual Intensive Update in Neurology 0915-162016

69

ICHD-III beta Criteria for Vestibular Migraine

bull A At least five attacks fulfilling criteria C and D

bull B A current or past history of 11 migraine without aura or 12 migraine with aura

bull C Vestibular symptoms of moderate or severe intensity lasting between 5 minutes and 72 hours

bull D At least 50 associated with one of the following migrainous features

ndash 1 Headaches

ndash 2 Photophobia and phonophobia

ndash 3 Visual Aura

bull E Not better accounted for by another vestibular disorder

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 55: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

55

SSCD

bull Positive middle ear pressure or loud sound stimulates ampullofugal endolymph flow -canal activation

bull Eye movements are tonic upwards with ipsilateral intorsion

Sixth Annual Intensive Update in Neurology 0915-162016

56

SSCD

bull Valsalva against a closed glottis or jugular compression causes increased intracranial pressure and ampullopetal endolymph flow -canal inhibition

bull Eye movements are tonic downwards with ipsilateral extorsion

Sixth Annual Intensive Update in Neurology 0915-162016

57

Reconstructed left superior semicircular canal

Sixth Annual Intensive Update in Neurology 0915-162016

58

Sixth Annual Intensive Update in Neurology 0915-162016

59

SCHEMATIC DRAWING OF AN OTOLITHIC MACULA

Sixth Annual Intensive Update in Neurology 0915-162016

60

MACULAE OF THE UTRICLESACCULE

Sixth Annual Intensive Update in Neurology 0915-162016

61

HAIR CELLS

Sixth Annual Intensive Update in Neurology 0915-162016

62

SCANNING ELECTRON MICROGRAPH OF OTOCONIA

Sixth Annual Intensive Update in Neurology 0915-162016

63

Ocular VEMP

bull Response to loud clicks (80-110 dB) or forehead tap (Halmagyi and Curthoys 2003)

bull Contralateral oculomotor nucleus (CN III)

bull Inferior oblique muscle contraction (8 msec) detected by 5sec event triggered averaging

bull Noninverting electrode inferior to eye

bull Inverting below non-inverting electrode

bull Ground to forehead

bull Normal subjects have very low response

Sixth Annual Intensive Update in Neurology 0915-162016

64

Clinical applications

bull The o-VEMP is a sensitive test of otolithutricular

function

bull Complements vestibular test procedures that assess

semicircular canals

bull Abnormally robust responses are associated with third

window abnormalities such as semicircular canal

dehiscence

bull Serves as an excellent screening test for semicircular

canal dehiscence

Sixth Annual Intensive Update in Neurology 0915-162016

65

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Sixth Annual Intensive Update in Neurology 0915-162016

66

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Answer 1 References at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

67

Enlarged vestibular aqueduct

bull Axial temporal bone CT showing right temporal bone with enlarged vestibular aqueduct (arrow)

bull Vestibular symptoms accompany progressive sensorineural hearing loss in 4-50 of patients in selected series

Sixth Annual Intensive Update in Neurology 0915-162016

68

Migraine

bull Family or personal history of migraine

bull 25 of migraine patients experience spontaneous vertigo (Baloh 1997)

bull Neuhauser criteria(2001) have been used to construct structured diagnostic interviews (Furman 2003)

bull Not always associated with headache

bull Motion sensitivity

bull Medication responsive

Sixth Annual Intensive Update in Neurology 0915-162016

69

ICHD-III beta Criteria for Vestibular Migraine

bull A At least five attacks fulfilling criteria C and D

bull B A current or past history of 11 migraine without aura or 12 migraine with aura

bull C Vestibular symptoms of moderate or severe intensity lasting between 5 minutes and 72 hours

bull D At least 50 associated with one of the following migrainous features

ndash 1 Headaches

ndash 2 Photophobia and phonophobia

ndash 3 Visual Aura

bull E Not better accounted for by another vestibular disorder

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 56: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

56

SSCD

bull Valsalva against a closed glottis or jugular compression causes increased intracranial pressure and ampullopetal endolymph flow -canal inhibition

bull Eye movements are tonic downwards with ipsilateral extorsion

Sixth Annual Intensive Update in Neurology 0915-162016

57

Reconstructed left superior semicircular canal

Sixth Annual Intensive Update in Neurology 0915-162016

58

Sixth Annual Intensive Update in Neurology 0915-162016

59

SCHEMATIC DRAWING OF AN OTOLITHIC MACULA

Sixth Annual Intensive Update in Neurology 0915-162016

60

MACULAE OF THE UTRICLESACCULE

Sixth Annual Intensive Update in Neurology 0915-162016

61

HAIR CELLS

Sixth Annual Intensive Update in Neurology 0915-162016

62

SCANNING ELECTRON MICROGRAPH OF OTOCONIA

Sixth Annual Intensive Update in Neurology 0915-162016

63

Ocular VEMP

bull Response to loud clicks (80-110 dB) or forehead tap (Halmagyi and Curthoys 2003)

bull Contralateral oculomotor nucleus (CN III)

bull Inferior oblique muscle contraction (8 msec) detected by 5sec event triggered averaging

bull Noninverting electrode inferior to eye

bull Inverting below non-inverting electrode

bull Ground to forehead

bull Normal subjects have very low response

Sixth Annual Intensive Update in Neurology 0915-162016

64

Clinical applications

bull The o-VEMP is a sensitive test of otolithutricular

function

bull Complements vestibular test procedures that assess

semicircular canals

bull Abnormally robust responses are associated with third

window abnormalities such as semicircular canal

dehiscence

bull Serves as an excellent screening test for semicircular

canal dehiscence

Sixth Annual Intensive Update in Neurology 0915-162016

65

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Sixth Annual Intensive Update in Neurology 0915-162016

66

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Answer 1 References at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

67

Enlarged vestibular aqueduct

bull Axial temporal bone CT showing right temporal bone with enlarged vestibular aqueduct (arrow)

bull Vestibular symptoms accompany progressive sensorineural hearing loss in 4-50 of patients in selected series

Sixth Annual Intensive Update in Neurology 0915-162016

68

Migraine

bull Family or personal history of migraine

bull 25 of migraine patients experience spontaneous vertigo (Baloh 1997)

bull Neuhauser criteria(2001) have been used to construct structured diagnostic interviews (Furman 2003)

bull Not always associated with headache

bull Motion sensitivity

bull Medication responsive

Sixth Annual Intensive Update in Neurology 0915-162016

69

ICHD-III beta Criteria for Vestibular Migraine

bull A At least five attacks fulfilling criteria C and D

bull B A current or past history of 11 migraine without aura or 12 migraine with aura

bull C Vestibular symptoms of moderate or severe intensity lasting between 5 minutes and 72 hours

bull D At least 50 associated with one of the following migrainous features

ndash 1 Headaches

ndash 2 Photophobia and phonophobia

ndash 3 Visual Aura

bull E Not better accounted for by another vestibular disorder

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 57: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

57

Reconstructed left superior semicircular canal

Sixth Annual Intensive Update in Neurology 0915-162016

58

Sixth Annual Intensive Update in Neurology 0915-162016

59

SCHEMATIC DRAWING OF AN OTOLITHIC MACULA

Sixth Annual Intensive Update in Neurology 0915-162016

60

MACULAE OF THE UTRICLESACCULE

Sixth Annual Intensive Update in Neurology 0915-162016

61

HAIR CELLS

Sixth Annual Intensive Update in Neurology 0915-162016

62

SCANNING ELECTRON MICROGRAPH OF OTOCONIA

Sixth Annual Intensive Update in Neurology 0915-162016

63

Ocular VEMP

bull Response to loud clicks (80-110 dB) or forehead tap (Halmagyi and Curthoys 2003)

bull Contralateral oculomotor nucleus (CN III)

bull Inferior oblique muscle contraction (8 msec) detected by 5sec event triggered averaging

bull Noninverting electrode inferior to eye

bull Inverting below non-inverting electrode

bull Ground to forehead

bull Normal subjects have very low response

Sixth Annual Intensive Update in Neurology 0915-162016

64

Clinical applications

bull The o-VEMP is a sensitive test of otolithutricular

function

bull Complements vestibular test procedures that assess

semicircular canals

bull Abnormally robust responses are associated with third

window abnormalities such as semicircular canal

dehiscence

bull Serves as an excellent screening test for semicircular

canal dehiscence

Sixth Annual Intensive Update in Neurology 0915-162016

65

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Sixth Annual Intensive Update in Neurology 0915-162016

66

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Answer 1 References at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

67

Enlarged vestibular aqueduct

bull Axial temporal bone CT showing right temporal bone with enlarged vestibular aqueduct (arrow)

bull Vestibular symptoms accompany progressive sensorineural hearing loss in 4-50 of patients in selected series

Sixth Annual Intensive Update in Neurology 0915-162016

68

Migraine

bull Family or personal history of migraine

bull 25 of migraine patients experience spontaneous vertigo (Baloh 1997)

bull Neuhauser criteria(2001) have been used to construct structured diagnostic interviews (Furman 2003)

bull Not always associated with headache

bull Motion sensitivity

bull Medication responsive

Sixth Annual Intensive Update in Neurology 0915-162016

69

ICHD-III beta Criteria for Vestibular Migraine

bull A At least five attacks fulfilling criteria C and D

bull B A current or past history of 11 migraine without aura or 12 migraine with aura

bull C Vestibular symptoms of moderate or severe intensity lasting between 5 minutes and 72 hours

bull D At least 50 associated with one of the following migrainous features

ndash 1 Headaches

ndash 2 Photophobia and phonophobia

ndash 3 Visual Aura

bull E Not better accounted for by another vestibular disorder

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 58: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

58

Sixth Annual Intensive Update in Neurology 0915-162016

59

SCHEMATIC DRAWING OF AN OTOLITHIC MACULA

Sixth Annual Intensive Update in Neurology 0915-162016

60

MACULAE OF THE UTRICLESACCULE

Sixth Annual Intensive Update in Neurology 0915-162016

61

HAIR CELLS

Sixth Annual Intensive Update in Neurology 0915-162016

62

SCANNING ELECTRON MICROGRAPH OF OTOCONIA

Sixth Annual Intensive Update in Neurology 0915-162016

63

Ocular VEMP

bull Response to loud clicks (80-110 dB) or forehead tap (Halmagyi and Curthoys 2003)

bull Contralateral oculomotor nucleus (CN III)

bull Inferior oblique muscle contraction (8 msec) detected by 5sec event triggered averaging

bull Noninverting electrode inferior to eye

bull Inverting below non-inverting electrode

bull Ground to forehead

bull Normal subjects have very low response

Sixth Annual Intensive Update in Neurology 0915-162016

64

Clinical applications

bull The o-VEMP is a sensitive test of otolithutricular

function

bull Complements vestibular test procedures that assess

semicircular canals

bull Abnormally robust responses are associated with third

window abnormalities such as semicircular canal

dehiscence

bull Serves as an excellent screening test for semicircular

canal dehiscence

Sixth Annual Intensive Update in Neurology 0915-162016

65

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Sixth Annual Intensive Update in Neurology 0915-162016

66

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Answer 1 References at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

67

Enlarged vestibular aqueduct

bull Axial temporal bone CT showing right temporal bone with enlarged vestibular aqueduct (arrow)

bull Vestibular symptoms accompany progressive sensorineural hearing loss in 4-50 of patients in selected series

Sixth Annual Intensive Update in Neurology 0915-162016

68

Migraine

bull Family or personal history of migraine

bull 25 of migraine patients experience spontaneous vertigo (Baloh 1997)

bull Neuhauser criteria(2001) have been used to construct structured diagnostic interviews (Furman 2003)

bull Not always associated with headache

bull Motion sensitivity

bull Medication responsive

Sixth Annual Intensive Update in Neurology 0915-162016

69

ICHD-III beta Criteria for Vestibular Migraine

bull A At least five attacks fulfilling criteria C and D

bull B A current or past history of 11 migraine without aura or 12 migraine with aura

bull C Vestibular symptoms of moderate or severe intensity lasting between 5 minutes and 72 hours

bull D At least 50 associated with one of the following migrainous features

ndash 1 Headaches

ndash 2 Photophobia and phonophobia

ndash 3 Visual Aura

bull E Not better accounted for by another vestibular disorder

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 59: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

59

SCHEMATIC DRAWING OF AN OTOLITHIC MACULA

Sixth Annual Intensive Update in Neurology 0915-162016

60

MACULAE OF THE UTRICLESACCULE

Sixth Annual Intensive Update in Neurology 0915-162016

61

HAIR CELLS

Sixth Annual Intensive Update in Neurology 0915-162016

62

SCANNING ELECTRON MICROGRAPH OF OTOCONIA

Sixth Annual Intensive Update in Neurology 0915-162016

63

Ocular VEMP

bull Response to loud clicks (80-110 dB) or forehead tap (Halmagyi and Curthoys 2003)

bull Contralateral oculomotor nucleus (CN III)

bull Inferior oblique muscle contraction (8 msec) detected by 5sec event triggered averaging

bull Noninverting electrode inferior to eye

bull Inverting below non-inverting electrode

bull Ground to forehead

bull Normal subjects have very low response

Sixth Annual Intensive Update in Neurology 0915-162016

64

Clinical applications

bull The o-VEMP is a sensitive test of otolithutricular

function

bull Complements vestibular test procedures that assess

semicircular canals

bull Abnormally robust responses are associated with third

window abnormalities such as semicircular canal

dehiscence

bull Serves as an excellent screening test for semicircular

canal dehiscence

Sixth Annual Intensive Update in Neurology 0915-162016

65

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Sixth Annual Intensive Update in Neurology 0915-162016

66

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Answer 1 References at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

67

Enlarged vestibular aqueduct

bull Axial temporal bone CT showing right temporal bone with enlarged vestibular aqueduct (arrow)

bull Vestibular symptoms accompany progressive sensorineural hearing loss in 4-50 of patients in selected series

Sixth Annual Intensive Update in Neurology 0915-162016

68

Migraine

bull Family or personal history of migraine

bull 25 of migraine patients experience spontaneous vertigo (Baloh 1997)

bull Neuhauser criteria(2001) have been used to construct structured diagnostic interviews (Furman 2003)

bull Not always associated with headache

bull Motion sensitivity

bull Medication responsive

Sixth Annual Intensive Update in Neurology 0915-162016

69

ICHD-III beta Criteria for Vestibular Migraine

bull A At least five attacks fulfilling criteria C and D

bull B A current or past history of 11 migraine without aura or 12 migraine with aura

bull C Vestibular symptoms of moderate or severe intensity lasting between 5 minutes and 72 hours

bull D At least 50 associated with one of the following migrainous features

ndash 1 Headaches

ndash 2 Photophobia and phonophobia

ndash 3 Visual Aura

bull E Not better accounted for by another vestibular disorder

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 60: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

60

MACULAE OF THE UTRICLESACCULE

Sixth Annual Intensive Update in Neurology 0915-162016

61

HAIR CELLS

Sixth Annual Intensive Update in Neurology 0915-162016

62

SCANNING ELECTRON MICROGRAPH OF OTOCONIA

Sixth Annual Intensive Update in Neurology 0915-162016

63

Ocular VEMP

bull Response to loud clicks (80-110 dB) or forehead tap (Halmagyi and Curthoys 2003)

bull Contralateral oculomotor nucleus (CN III)

bull Inferior oblique muscle contraction (8 msec) detected by 5sec event triggered averaging

bull Noninverting electrode inferior to eye

bull Inverting below non-inverting electrode

bull Ground to forehead

bull Normal subjects have very low response

Sixth Annual Intensive Update in Neurology 0915-162016

64

Clinical applications

bull The o-VEMP is a sensitive test of otolithutricular

function

bull Complements vestibular test procedures that assess

semicircular canals

bull Abnormally robust responses are associated with third

window abnormalities such as semicircular canal

dehiscence

bull Serves as an excellent screening test for semicircular

canal dehiscence

Sixth Annual Intensive Update in Neurology 0915-162016

65

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Sixth Annual Intensive Update in Neurology 0915-162016

66

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Answer 1 References at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

67

Enlarged vestibular aqueduct

bull Axial temporal bone CT showing right temporal bone with enlarged vestibular aqueduct (arrow)

bull Vestibular symptoms accompany progressive sensorineural hearing loss in 4-50 of patients in selected series

Sixth Annual Intensive Update in Neurology 0915-162016

68

Migraine

bull Family or personal history of migraine

bull 25 of migraine patients experience spontaneous vertigo (Baloh 1997)

bull Neuhauser criteria(2001) have been used to construct structured diagnostic interviews (Furman 2003)

bull Not always associated with headache

bull Motion sensitivity

bull Medication responsive

Sixth Annual Intensive Update in Neurology 0915-162016

69

ICHD-III beta Criteria for Vestibular Migraine

bull A At least five attacks fulfilling criteria C and D

bull B A current or past history of 11 migraine without aura or 12 migraine with aura

bull C Vestibular symptoms of moderate or severe intensity lasting between 5 minutes and 72 hours

bull D At least 50 associated with one of the following migrainous features

ndash 1 Headaches

ndash 2 Photophobia and phonophobia

ndash 3 Visual Aura

bull E Not better accounted for by another vestibular disorder

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 61: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

61

HAIR CELLS

Sixth Annual Intensive Update in Neurology 0915-162016

62

SCANNING ELECTRON MICROGRAPH OF OTOCONIA

Sixth Annual Intensive Update in Neurology 0915-162016

63

Ocular VEMP

bull Response to loud clicks (80-110 dB) or forehead tap (Halmagyi and Curthoys 2003)

bull Contralateral oculomotor nucleus (CN III)

bull Inferior oblique muscle contraction (8 msec) detected by 5sec event triggered averaging

bull Noninverting electrode inferior to eye

bull Inverting below non-inverting electrode

bull Ground to forehead

bull Normal subjects have very low response

Sixth Annual Intensive Update in Neurology 0915-162016

64

Clinical applications

bull The o-VEMP is a sensitive test of otolithutricular

function

bull Complements vestibular test procedures that assess

semicircular canals

bull Abnormally robust responses are associated with third

window abnormalities such as semicircular canal

dehiscence

bull Serves as an excellent screening test for semicircular

canal dehiscence

Sixth Annual Intensive Update in Neurology 0915-162016

65

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Sixth Annual Intensive Update in Neurology 0915-162016

66

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Answer 1 References at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

67

Enlarged vestibular aqueduct

bull Axial temporal bone CT showing right temporal bone with enlarged vestibular aqueduct (arrow)

bull Vestibular symptoms accompany progressive sensorineural hearing loss in 4-50 of patients in selected series

Sixth Annual Intensive Update in Neurology 0915-162016

68

Migraine

bull Family or personal history of migraine

bull 25 of migraine patients experience spontaneous vertigo (Baloh 1997)

bull Neuhauser criteria(2001) have been used to construct structured diagnostic interviews (Furman 2003)

bull Not always associated with headache

bull Motion sensitivity

bull Medication responsive

Sixth Annual Intensive Update in Neurology 0915-162016

69

ICHD-III beta Criteria for Vestibular Migraine

bull A At least five attacks fulfilling criteria C and D

bull B A current or past history of 11 migraine without aura or 12 migraine with aura

bull C Vestibular symptoms of moderate or severe intensity lasting between 5 minutes and 72 hours

bull D At least 50 associated with one of the following migrainous features

ndash 1 Headaches

ndash 2 Photophobia and phonophobia

ndash 3 Visual Aura

bull E Not better accounted for by another vestibular disorder

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 62: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

62

SCANNING ELECTRON MICROGRAPH OF OTOCONIA

Sixth Annual Intensive Update in Neurology 0915-162016

63

Ocular VEMP

bull Response to loud clicks (80-110 dB) or forehead tap (Halmagyi and Curthoys 2003)

bull Contralateral oculomotor nucleus (CN III)

bull Inferior oblique muscle contraction (8 msec) detected by 5sec event triggered averaging

bull Noninverting electrode inferior to eye

bull Inverting below non-inverting electrode

bull Ground to forehead

bull Normal subjects have very low response

Sixth Annual Intensive Update in Neurology 0915-162016

64

Clinical applications

bull The o-VEMP is a sensitive test of otolithutricular

function

bull Complements vestibular test procedures that assess

semicircular canals

bull Abnormally robust responses are associated with third

window abnormalities such as semicircular canal

dehiscence

bull Serves as an excellent screening test for semicircular

canal dehiscence

Sixth Annual Intensive Update in Neurology 0915-162016

65

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Sixth Annual Intensive Update in Neurology 0915-162016

66

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Answer 1 References at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

67

Enlarged vestibular aqueduct

bull Axial temporal bone CT showing right temporal bone with enlarged vestibular aqueduct (arrow)

bull Vestibular symptoms accompany progressive sensorineural hearing loss in 4-50 of patients in selected series

Sixth Annual Intensive Update in Neurology 0915-162016

68

Migraine

bull Family or personal history of migraine

bull 25 of migraine patients experience spontaneous vertigo (Baloh 1997)

bull Neuhauser criteria(2001) have been used to construct structured diagnostic interviews (Furman 2003)

bull Not always associated with headache

bull Motion sensitivity

bull Medication responsive

Sixth Annual Intensive Update in Neurology 0915-162016

69

ICHD-III beta Criteria for Vestibular Migraine

bull A At least five attacks fulfilling criteria C and D

bull B A current or past history of 11 migraine without aura or 12 migraine with aura

bull C Vestibular symptoms of moderate or severe intensity lasting between 5 minutes and 72 hours

bull D At least 50 associated with one of the following migrainous features

ndash 1 Headaches

ndash 2 Photophobia and phonophobia

ndash 3 Visual Aura

bull E Not better accounted for by another vestibular disorder

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 63: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

63

Ocular VEMP

bull Response to loud clicks (80-110 dB) or forehead tap (Halmagyi and Curthoys 2003)

bull Contralateral oculomotor nucleus (CN III)

bull Inferior oblique muscle contraction (8 msec) detected by 5sec event triggered averaging

bull Noninverting electrode inferior to eye

bull Inverting below non-inverting electrode

bull Ground to forehead

bull Normal subjects have very low response

Sixth Annual Intensive Update in Neurology 0915-162016

64

Clinical applications

bull The o-VEMP is a sensitive test of otolithutricular

function

bull Complements vestibular test procedures that assess

semicircular canals

bull Abnormally robust responses are associated with third

window abnormalities such as semicircular canal

dehiscence

bull Serves as an excellent screening test for semicircular

canal dehiscence

Sixth Annual Intensive Update in Neurology 0915-162016

65

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Sixth Annual Intensive Update in Neurology 0915-162016

66

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Answer 1 References at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

67

Enlarged vestibular aqueduct

bull Axial temporal bone CT showing right temporal bone with enlarged vestibular aqueduct (arrow)

bull Vestibular symptoms accompany progressive sensorineural hearing loss in 4-50 of patients in selected series

Sixth Annual Intensive Update in Neurology 0915-162016

68

Migraine

bull Family or personal history of migraine

bull 25 of migraine patients experience spontaneous vertigo (Baloh 1997)

bull Neuhauser criteria(2001) have been used to construct structured diagnostic interviews (Furman 2003)

bull Not always associated with headache

bull Motion sensitivity

bull Medication responsive

Sixth Annual Intensive Update in Neurology 0915-162016

69

ICHD-III beta Criteria for Vestibular Migraine

bull A At least five attacks fulfilling criteria C and D

bull B A current or past history of 11 migraine without aura or 12 migraine with aura

bull C Vestibular symptoms of moderate or severe intensity lasting between 5 minutes and 72 hours

bull D At least 50 associated with one of the following migrainous features

ndash 1 Headaches

ndash 2 Photophobia and phonophobia

ndash 3 Visual Aura

bull E Not better accounted for by another vestibular disorder

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 64: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

64

Clinical applications

bull The o-VEMP is a sensitive test of otolithutricular

function

bull Complements vestibular test procedures that assess

semicircular canals

bull Abnormally robust responses are associated with third

window abnormalities such as semicircular canal

dehiscence

bull Serves as an excellent screening test for semicircular

canal dehiscence

Sixth Annual Intensive Update in Neurology 0915-162016

65

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Sixth Annual Intensive Update in Neurology 0915-162016

66

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Answer 1 References at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

67

Enlarged vestibular aqueduct

bull Axial temporal bone CT showing right temporal bone with enlarged vestibular aqueduct (arrow)

bull Vestibular symptoms accompany progressive sensorineural hearing loss in 4-50 of patients in selected series

Sixth Annual Intensive Update in Neurology 0915-162016

68

Migraine

bull Family or personal history of migraine

bull 25 of migraine patients experience spontaneous vertigo (Baloh 1997)

bull Neuhauser criteria(2001) have been used to construct structured diagnostic interviews (Furman 2003)

bull Not always associated with headache

bull Motion sensitivity

bull Medication responsive

Sixth Annual Intensive Update in Neurology 0915-162016

69

ICHD-III beta Criteria for Vestibular Migraine

bull A At least five attacks fulfilling criteria C and D

bull B A current or past history of 11 migraine without aura or 12 migraine with aura

bull C Vestibular symptoms of moderate or severe intensity lasting between 5 minutes and 72 hours

bull D At least 50 associated with one of the following migrainous features

ndash 1 Headaches

ndash 2 Photophobia and phonophobia

ndash 3 Visual Aura

bull E Not better accounted for by another vestibular disorder

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 65: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

65

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Sixth Annual Intensive Update in Neurology 0915-162016

66

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Answer 1 References at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

67

Enlarged vestibular aqueduct

bull Axial temporal bone CT showing right temporal bone with enlarged vestibular aqueduct (arrow)

bull Vestibular symptoms accompany progressive sensorineural hearing loss in 4-50 of patients in selected series

Sixth Annual Intensive Update in Neurology 0915-162016

68

Migraine

bull Family or personal history of migraine

bull 25 of migraine patients experience spontaneous vertigo (Baloh 1997)

bull Neuhauser criteria(2001) have been used to construct structured diagnostic interviews (Furman 2003)

bull Not always associated with headache

bull Motion sensitivity

bull Medication responsive

Sixth Annual Intensive Update in Neurology 0915-162016

69

ICHD-III beta Criteria for Vestibular Migraine

bull A At least five attacks fulfilling criteria C and D

bull B A current or past history of 11 migraine without aura or 12 migraine with aura

bull C Vestibular symptoms of moderate or severe intensity lasting between 5 minutes and 72 hours

bull D At least 50 associated with one of the following migrainous features

ndash 1 Headaches

ndash 2 Photophobia and phonophobia

ndash 3 Visual Aura

bull E Not better accounted for by another vestibular disorder

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 66: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

66

Question 5

bull Superior semicircular canal dehiscence

1) Causes increased ability to hear vibratory sounds

2) Improves hearing

3) Causes meningitis

4) Always needs surgical repair

Answer 1 References at end of lecture

Sixth Annual Intensive Update in Neurology 0915-162016

67

Enlarged vestibular aqueduct

bull Axial temporal bone CT showing right temporal bone with enlarged vestibular aqueduct (arrow)

bull Vestibular symptoms accompany progressive sensorineural hearing loss in 4-50 of patients in selected series

Sixth Annual Intensive Update in Neurology 0915-162016

68

Migraine

bull Family or personal history of migraine

bull 25 of migraine patients experience spontaneous vertigo (Baloh 1997)

bull Neuhauser criteria(2001) have been used to construct structured diagnostic interviews (Furman 2003)

bull Not always associated with headache

bull Motion sensitivity

bull Medication responsive

Sixth Annual Intensive Update in Neurology 0915-162016

69

ICHD-III beta Criteria for Vestibular Migraine

bull A At least five attacks fulfilling criteria C and D

bull B A current or past history of 11 migraine without aura or 12 migraine with aura

bull C Vestibular symptoms of moderate or severe intensity lasting between 5 minutes and 72 hours

bull D At least 50 associated with one of the following migrainous features

ndash 1 Headaches

ndash 2 Photophobia and phonophobia

ndash 3 Visual Aura

bull E Not better accounted for by another vestibular disorder

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 67: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

67

Enlarged vestibular aqueduct

bull Axial temporal bone CT showing right temporal bone with enlarged vestibular aqueduct (arrow)

bull Vestibular symptoms accompany progressive sensorineural hearing loss in 4-50 of patients in selected series

Sixth Annual Intensive Update in Neurology 0915-162016

68

Migraine

bull Family or personal history of migraine

bull 25 of migraine patients experience spontaneous vertigo (Baloh 1997)

bull Neuhauser criteria(2001) have been used to construct structured diagnostic interviews (Furman 2003)

bull Not always associated with headache

bull Motion sensitivity

bull Medication responsive

Sixth Annual Intensive Update in Neurology 0915-162016

69

ICHD-III beta Criteria for Vestibular Migraine

bull A At least five attacks fulfilling criteria C and D

bull B A current or past history of 11 migraine without aura or 12 migraine with aura

bull C Vestibular symptoms of moderate or severe intensity lasting between 5 minutes and 72 hours

bull D At least 50 associated with one of the following migrainous features

ndash 1 Headaches

ndash 2 Photophobia and phonophobia

ndash 3 Visual Aura

bull E Not better accounted for by another vestibular disorder

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 68: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

68

Migraine

bull Family or personal history of migraine

bull 25 of migraine patients experience spontaneous vertigo (Baloh 1997)

bull Neuhauser criteria(2001) have been used to construct structured diagnostic interviews (Furman 2003)

bull Not always associated with headache

bull Motion sensitivity

bull Medication responsive

Sixth Annual Intensive Update in Neurology 0915-162016

69

ICHD-III beta Criteria for Vestibular Migraine

bull A At least five attacks fulfilling criteria C and D

bull B A current or past history of 11 migraine without aura or 12 migraine with aura

bull C Vestibular symptoms of moderate or severe intensity lasting between 5 minutes and 72 hours

bull D At least 50 associated with one of the following migrainous features

ndash 1 Headaches

ndash 2 Photophobia and phonophobia

ndash 3 Visual Aura

bull E Not better accounted for by another vestibular disorder

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 69: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

69

ICHD-III beta Criteria for Vestibular Migraine

bull A At least five attacks fulfilling criteria C and D

bull B A current or past history of 11 migraine without aura or 12 migraine with aura

bull C Vestibular symptoms of moderate or severe intensity lasting between 5 minutes and 72 hours

bull D At least 50 associated with one of the following migrainous features

ndash 1 Headaches

ndash 2 Photophobia and phonophobia

ndash 3 Visual Aura

bull E Not better accounted for by another vestibular disorder

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 70: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

70

Incidence of vertigo in MS

bull True vertigo (the perception of environmental

movement typically rotational) occurs in about

20 of MS patients and is the presenting

manifestation in 5

bull Up to 78 of MS patients report abnormalities

in balance at some point in their illness

Frohman et al Multiple Sclerosis 2003 9250

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 71: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

71

Vertigo in MS due to demyelination

bull The most common neuroanatomic locations are the

root entry zone of CN VIII (giving absent calorics but

normal hearing and fixation suppression) and the

medial vestibular nucleus

bull Usually treated with steroids and vestibular

suppressants

Brandt 1993 Gass 1998 Thomke 1999

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 72: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

72

Vertigo in MS

Frohmanrsquos large series (1153) reported that 52 of MS patients with acute vertigo had benign paroxysmal positional vertigo while 32 had new brainstem lesions

To avoid misdiagnoses and inappropriate treatment interventions alternative etiologies should be considered in all acute vertigo episodes in MS

E M Frohman Neurology 2000 and Multiple Sclerosis 2003

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 73: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

73

Vestibular compensation

bull Acute unilateral or bilateral vestibular loss will prompt compensation thru central cervico-ocular visual and proprioceptive pathways

bull Unilateral loss may require several weeks for compensation to occur and activity especially head movements hastens compensation

bull Vestibular suppressant medication prolongs compensation

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 74: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

74

Vestibular Rehabilitation

bull Performed by certified physical therapists many sites (Epic order vestibular PT) or check Vestibular Disorders of America website for providers

bull Assessment and treatment of benign positional vertigo

bull Directed rehab programs for central andor peripheral vestibular compensationndash Unilateral vestibulopathies

ndash Bilateral vestibular hypofunction

ndash Mutifactorial balance deficits and fall risk assessment

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 75: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

75

Summary of whatrsquos new in peripheral vestibular disorders

bull Lateral semicircular canal benign paroxysmal positional vertigo presents with horizontal positioning nystagmus

bull Oral steroids appear to improve outcome in acute vestibular neuritis

bull Intratympanic steroids offer promise in Menierersquos syndrome

bull Superior semicircular canal dehiscence causes pressure and noise induced dizziness VEMP offers diagnostic information

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58

Page 76: The Dizzy Patient 2016 - swedish.org/media/Images/Swedish/CME1/SyllabusPDFs...6 History Onset –detailed description of first episode and most recent episode –Character –Frequency

Sixth Annual Intensive Update in Neurology 0915-162016

76

References

BPPVndash White J Benign paroxysmal positional vertigo Cleveland Clinic Journal of

Medicine 71(9)722-728 2004

ndash White J Coale K Catalano P Oas J Diagnosis and management of lateral semicircular canal benign positional vertigo Otolaryngology-Head and Neck Surgery 133 278-284 2005

ndash White J Savvides P Cherian N Oas J Canalith repositioning for benign paroxysmal positional vertigo Otology and Neurotology 26 704-710 2005

ndash White J Oas J Diagnosis and management of lateral semicircular canal conversions during particle repositioning therapy Laryngoscope 115(10) 1895-1897 2005

ndash Acute Vestibular Syndrome Hotson JR Baloh RW N Engl J Med 1998 Sep 3339(10)680-5

ndash Methylprednisolone valacyclovir or the combination for vestibular neuritis Strupp M Zingler VC Arbusow V Niklas D Maag KP Dieterich M Bense S Theil D Jahn K Brandt T N Engl J Med 2004 Jul 22351(4)354-61

ndash Intratympanic steroids for Meacuteniegraveres disease or syndrome Phillips JS Westerberg BCochrane Database Syst Rev 2011 Jul 6(7)CD008514 Review

ndash Sound- andor pressure-induced vertigo due to bone dehiscence of the superior semicircular canal Minor LB Solomon D Zinreich JS Zee DSArch Otolaryngol Head Neck Surg 1998 Mar124(3)249-58