THE CLASS LEADERS - Aging Matters€¦ · THE CLASS LEADERS The anti-cataract eye-drop In this...

1AGINGMATTERS

No1, 2017

THE CLASS LEADERS

The anti-cataract eye-drop

In this issue:

How to get your omegas from plant oils

The wrinkle remover

Peptide bioregulator gene-switches

US $8 / EU €6 / GB £5

The in-house magazine for the IAS Private Members Club

2 AGINGMATTERS

Quality: We stock the best quality products because the right materials and formulas give you the best possible results.

Brands: We carry original brands - i.e. the same ones used by top health professionals.

Support: Our friendly and professional customer care team are on-hand to help you. We can be bothered!

IAS is dedicated to helping you access the world’s latest commercially available supplements to give you and your family real choices.

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TOMORROW’S TREATMENTS TODAY™ Declaration: The IAS Aging Matters™ magazine is intended for IAS private club members (and therefore is not intended for the public). It focuses on the latest international nutritional, hormonal and drug therapies to help combat the signs of aging. These signs include the physical, mental and internal changes consisting of the diseases and disorders such as cancer, arthritis and senile dementias etc. However, the main focus is upon the prevention of such aging diseases and disorders for the healthy-aging’ individual.

Copyright 2017: All copyrights are acknowledged. Whilst every eff ort has been made to ensure accuracy, no responsibility can be accepted for illustrations, photographs, artwork or advertising materials while in transmission or with the publisher or their agents. Disclaimer: All educational information is off ered under IAS terms and conditions. This information does not replace the advice of your physician and restrictions may apply in some countries. The opinions expressed by the writers may not be those of IAS or the magazine. All prices shown are in US Dollars and are for reference purposes only and they do not include taxes (where applicable), nor do they include shipping & handling fees. Prices, conditions and terms are subject to change without notice.

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www.antiaging-systems.com | Order Hotline: 1-866-800-4677 | Email: [email protected]

3AGINGMATTERS

It’s 2017 and we trust that this New Year brings you and your family happiness, prosperity and above all- health.

Obviously, without good health we can’t help ourselves or others. That’s why; we thought that we’d start the year with a reminder of some of the class leading remedies. For example; how to rescue and improve aging eyesight; plus how to ensure good arterial and heart health; how to remove and reduce the appearance of wrinkles and also why the discovery of peptide bioregulators to act as gene-switches is so important. We hope there is something here for you.

Please note that there will be some changes to the Aging Matters™ magazine.

WELCOME

CONTENTS

Fundamentally, there will be 4 issues per year rather than the previous 6, but each issue will be bigger than before and they will have a broader range of topics, including articles, interviews, book reviews and other interesting subjects that are current and hot.

So we hope you will join us as we enter 2017 with a renewed vigor and zest for life and health.

Phil Micans, MS, PharmBEditor, Aging Matters™ Magazine

Ward Dean, M.D.Medical Director

03WelcomeA Happy New Year

04ForefrontInteresting items in the news

04Can teeth really repair them-selves naturally?

06Heart of the matter

08Research suggests the appendix has a purpose after all

10The aging brain

16Reversing andpreventing cataracts it’s been known for more than 15-years!

22Why plants are better than fi sh for omegas How PEOs deliver the right balance

53A-Z product listing and pricesFind everything in-stock here

58Contact details & payment optionsGet in touch with IAS today

60March 2017 price list48

Cross-reference lists Find what you need here

57Testimonials & Explanations Nice comments from nice people

FEATURED PRODUCTS12Centrophenoxine

13Deprenyl

14Piracetam

15MZS Melatonin

36Esnatri

37Thyroid Support

44Youth Gems

45GHRPs

46Oxytocin

47BioClip® Cuff

30The proven -topical wrinkle remover Tretinoin cream remains unbeaten

38Peptide bioregulators are gene switchesWhy is this so important?

CONTENTS

4 AGINGMATTERS www.antiaging-systems.com | Order Hotline: 1-866-800-4677 | Email: [email protected]

A new approach to dentistry could be a game changer for dentists and herald the end of numb mouths and painful drilling. A simple no pain approach banishing man made cements which are prone to infection and often need replacing a number of times.

Scientists have discovered that a drug already trialled in Alzheimer’s patients can encourage tooth regrowth and repair cavities. In the future dentists could just regrow your teeth, putting an end to fi llings!

This discovery came from researchers at King's College London. The team found that the drug Tideglusib stimulates the stem cells contained in the pulp of teeth so that they generate new dentine – the mineralised material under the enamel. We already know that teeth have the capability of regenerating dentine if the pulp inside the tooth becomes exposed through a trauma or infection, but can only naturally make a very thin layer which isn’t enough to fi ll the deep cavities caused by tooth decay.

The drug Tideglusib switches off an enzyme called GSK-3 which prevents dentine to keep forming. Scientists revealed it is possible to soak a small biodegradable sponge with the drug and insert it into a cavity, where it triggers the growth of dentine and repairs the damage within six weeks. The tiny sponges are made out of collagen so they melt away, leaving only the repaired tooth.

The lead author of the study, Professor Paul Sharpe of the Dental Institute, from King’s College London, said: “The simplicity of our approach makes it ideal as a clinical dental product for the natural treatment of large cavities, by providing both pulp protection and restoring dentine. He also said: “In addition, using a drug that has already been tested in clinical trials for Alzheimer’s disease provides a real opportunity to get this dental treatment quickly into clinics.”

Dentists currently use man-made cements or fi llings, such as calcium and silicon-based products, to treat larger cavities and

fi ll holes in teeth. But, the cement remains in the tooth and fails to disintegrate, meaning that the normal mineral level of the tooth is never completely restored. The new technique could reduce the need for fi llings of cements, which are prone to infection and often need replacing a number of times. When fi llings fail or infection occurs, dentists have to remove and fi ll an area that is larger than what is aff ected, and after multiple treatments the tooth may eventually need to be taken out.

Dr Nigel Carter, CEO of the Oral Health Foundation commented on the discovery: “This is an extremely interesting and novel approach which shows great promise and we will look forward to it being translated into clinical application that could undoubtedly be a progressive step in the treatment of dental disease.” He added: “While fi llings have remained highly eff ective in repairing large cavities, they are susceptible to wear-and-tear and can occasionally be in need of repair and replacement. This presents problems as the dentist could have to remove and fi ll a larger area each time and after numerous treatments the tooth may then have to be extracted.”

He concluded: “Creating a more natural way for the tooth to repair itself could not only eliminate these issues, but also be a far less invasive treatment option for patients. With dental phobia still being very common, using a natural way to stimulate the renewal of dentine could be an especially comforting proposal for these groups, for which undergoing treatment can often be a cause great anxiety.”

Whilst this is a ground breaking discovery, the procedure has so far only been used in mouse teeth, but it was shown to 'fi ll the whole injury site'.

As to when patients might start seeing Tideglusib at their local dentist, it will likely be at least a few more years. The American Dental Association (ADA) has indicated that it’s “too soon” to know whether or not the procedure has any viable clinical application. But if the drug is truly safe and works in animals, it will likely have similar benefi ts in humans.

The drug Tideglusib has already been shown to be safe in clinical trials of patients with Alzheimer's disease so scientists say that the treatment could be fast-tracked into dental practices.

Treating cavities with standard dental fi llings may soon be a distant memory because of a new era of regenerative medicine. We now have the restorative tools needed to consign fi llings to history.

CAN TEETH REALLY REPAIR THEMSELVESNATURALLY?

FOREFRONT

5www.antiaging-systems.com | Order Hotline: 1-866-800-4677 | Email: [email protected] AGINGMATTERS

FOREFRONT

The tooth regenerates by forming a layer of hard dentine over cavities potentially repairing themselves naturally.


Statins are a class of lipid-lowering medications normally associated with cardiovascular disease. They are considered one of the most profi table medications produced by the Big Pharma's. The National Center for Health Statistics claims that 50% of men age 65-74, and 40% of women over the age of 75 take a statin medication. It was reported that 32 million Americans were taking a statin drug in a study in 2011.

The statin drug study has shown that cholesterol lowering statins increase the progression of coronary artery calcifi cation. In most cases, cardiologists order coronary artery calcium scores to assess how much calcium is deposited in the coronary arteries. The higher the coronary artery calcium score, the more risk there is for having a heart attack. According to the Cleveland Clinic, “Coronary calcium scores are the most sensitive approaches to detecting coronary calcifi cation from atherosclerosis before symptoms develop.”

The team of researchers studied eight prospective randomized trials using coronary intravascular ultrasound looking for serial changes in the calcium burden in the coronary arteries. The authors grouped the subjects into three groups; those treated with high-intensity statin therapy, low-intensity statin therapy, and no-statin therapy. The scientists found that all three groups were found to have signifi cant increases in coronary calcium scores when the groups were compared to baseline. The high-intensity group had the largest calcium increase and the low-intensity statin group was next in line followed by the no-statin group.

Physicians have been testing untold numbers of patients for their coronary calcium score. When the score is too high, they are told that they are at an increased risk for a cardiac event. The patients are then prescribed statin medications and frequently told to undergo further testing to evaluate the coronary arteries.

An article in The Journal of the American College of Cardiology investigated whether the use of stains infl uences the progression of coronary artery calcifi cation during fi ve years of follow-up in subjects who took a statin medication and compared them to subjects who did not take a statin drug. The scientists reported that subjects who took statins for fi ve years, when compared to those that took a placebo, were found to have an alarming 2-fold increase in coronary artery calcifi cation progression.

A board-certifi ed family physician and Medical Director of the Center of Holistic Medicine in West Bloomfi eld. Dr David Brownststein has written a book called 'The Satin Disaster'. He believes that Statins worsen the calcifi cation of the coronary arteries and he believes that statin drugs are a colossal failure. At their best, they work to lower the risk of a heart attack in approximately 1%. He says that there is no justifi cation for the mass prescribing of a class of medications that fail nearly all who take them. Furthermore, it is important to keep in mind that statins are not benign drugs as they are associated with a host of serious side eff ects including muscle aches and pains, neuropathy, and cancer.

Dr. Brownstein further says: “Statins are the perfect example of a class of medications that is bankrupting our medical system: As the new administration takes charge in Washington, D.C., I hope someone will look at our medical care and make rational decisions about which drugs should be used and which should not.

”He added: “In the case of statin medications, a rational mind would conclude that this class of medications should be pulled from the market place. More information about statins can be found in my book, The Statin Disaster.”

www.drbrownstein.com/The-Statin-Disaster-p/statindisaster.htm

It is also recommended to watch these important documentaries produced by medical doctors on statin drug.

The cholesterol drug war, part 1: https://www.youtube.com/watch?v=sGIGXfIDaJo

The cholesterol drug war, part 2: https://www.youtube.com/watch?v=AY4eTGMe-EY

HEART OF THE MATTER Cholesterol-lowering statin drugs increase progression of coronary artery calcifi cation

FOREFRONT


FOREFRONT

A class of expensive medications that fail most who take them and are associated with serious side eff ects, is Bankrupting our medical system.


The appendix has long been a bit of a mystery. A worm-like strip that projects off at the crossroads of the small and large intestines, called the cecum. Conventional wisdom states that the human appendix is the shrunken remnant of an organ that once played an important role in a remote ancestor of humans millions of years ago. The reason it still exists and occasionally has to be removed due to potentially fatal infl ammation and rupturing – is that it is too evolutionary expensive to get rid of altogether. There’s little evolutionary pressure to lose such a signifi cant part of the body.

However, it’s commonly considered a useless evolutionary throwback whose sole purpose is to give you a nasty case of appendicitis. Although, for the majority of people - it just sits there not hurting anyone.

The human body has a number of 'vestigial' parts - appendix, wisdom teeth and tailbone - that gradually fell out of use as we adapted to more advanced lifestyles than our primitive ancestors.

A new study out says our appendix could actually serve an important biological function - and one that humans aren’t ready to give up.

Researchers from Midwestern University in the USA traced the appearance, disappearance, and re-emergence of the appendix in several mammal lineages over the past 11 million years, to work out how many times it was cut and brought back due to evolutionary pressures.

The team found that the organ has evolved at least 29 times – maybe, as many as 41 times - throughout mammalian evolution, and has only been lost a maximum of 12 times."This statistically strong evidence that the appearance of the appendix is signifi cantly more probable than its loss suggests a selective value for this structure," they reported.

"Thus, we can confi dently reject the hypothesis that the appendix is a vestigial structure with little adaptive value or function among mammals."

To understand more, read the Comptes Rendus Palevol articles. Devoted to palaeontology, pre-history and evolutionary sciences. For decades, researchers have been searching for a possible function of the human appendix, and the most likely theory is that it’s a haven for 'good' intestinal bacteria that help us keep certain infections at bay.

One of the best pieces of evidence they’ve had for this suggestion is a 2012 study by Bill Parker, which found that individuals without an appendix were four times more likely to have a recurrence of Clostridium diffi cile colitis - a bacterial infection that causes diarrhoea, fever, nausea, and abdominal pain.

Researchers discovered that species that had retained or regained an appendix had higher average concentrations of lymphoid (immune) tissue in the cecum - a small pouch connected to the junction of the small and large intestines.

Their fi ndings suggest that the appendix could play an important role in a species' immune system, particularly as lymphatic tissue is known to stimulate the growth of certain types of benefi cial gut bacteria.

"While these links between the appendix and cecal factors have been suggested before, this is the fi rst time they have been statistically validated,"

"The association between appendix presence and lymphoid tissue provides support for the immune hypothesis of appendix evolution."

The study is yet to be conclusive, but off ers a diff erent perspective on the hypothesis that humans have been keeping the appendix around for its immune support this whole time.The challenge now is to prove it, which is easier said than done, seeing as most people who have had their appendix removed don't suff er from any adverse long-term eff ects.

But it could be that when people get their appendix removed, immune cell-producing tissues in the cecum and elsewhere in the body step up to compensate for the loss. In conclusion, something that most people regard as a functionless body part may save your life. Your appendix may help you recover from serious infections.

FOREFRONT

RESEARCH SUGGESTSTHE APPENDIX HAS A PURPOSE AFTER ALL


FOREFRONT

Our appendix could actually serve an important biological function - and one that humans aren’t ready to give up.


As we age, deterioration of the brain sneaks up on most of us. The fi rst clue might be hearing loss. We may be forced into bifocals, even trifocals. Our refl exes slow down, we walk and act slower and we even talk slower. Our memory starts to fail, especially the short-term form of memory ability that is so crucial for learning new things. When brain cells die or are damaged for any reason, healthy neurons are assaulted by infl ammatory chemicals, like cytokines, that are released by the brain’s immune cell system. Brain infl ammation is commonly caused by infections such as colds and fl u and by diets defi cient in anti-oxidants.

The brain is home to two kinds of cells – neurons and glia, with the latter protecting the former. The diff erence between a young brain and an old brain isn't so much the number of neurons but the presence and function of supporting cells called glia.

In Cell Reports on January 10, researchers who examined postmortem brain samples from 480 individuals ranging in age from 16 to 106 found that the condition of someone's glia is so consistent through the years that it can be used to predict someone's age. The research lays the foundation to better understand glia's role in late-in-life brain disease.

Jernej Ule, a neurobiologist at the Francis Crick Institute and the University College London, who led the study with departmental colleague Rickie Patani (@PataniLab) and fi rst author Lilach Soreq reported: "We extensively characterized aging-altered gene expression changes across 10 human brain regions and found that, in fact, glia cells experience bigger changes than neurons." Jerney added: "There's quite a bit of regional information that will be of interest to diff erent people - for example some will notice a very unique pattern of astrocyte-specifi c changes in the substantia nigra - and we provide a lot of data that still needs to be analyzed."

There are three types of glia cells, each providing diff erent kinds of support to neurons: oligodendrocytes insulate, microglia act as immune cells, and astrocytes help with neuron metabolism, detoxifi cation, among many functions. Based on analysis of human brain tissue samples, primarily from the UK Brain Expression Consortium, the team of researchers show that astrocytes and oligodendrocytes shift their regional gene expression patterns upon aging, (e.g., which genes are turned on or off ) particularly in the hippocampus and substantia nigra - important brain regions for memory and movement, respectively - while the expression of microglia-specifi c genes increases in all brain regions.

Following on from that, the investigators took a preliminary look at whether these changes in gene expression could relate to changes in brain cell populations. Based on a comparison of tissue samples from 3 young and 3 old brains, they found that the number of oligodendrocytes decreases with age in the frontal cortex. The researchers further established that this likely corresponds with decreased expression of oligodendrocyte specifi c genes. Other types of cells had more complex patterns of change.

"We developed a very nice machine learning program and had to go through hundreds of thousands of oligodendrocytes and neurons to get reliable data, but we wanted to understand whether decreased expression causes changes at the molecular or cellular-level," Jernej Ule says: "We did see oligodendrocytes disappearing but with neurons we didn't see dramatic changes in cellular numbers except fora decrease in the largest neurons. This is of interest because those largest neurons are generally connected to neurodegenerative diseases."

One unexpected discovery was that certain glia gene expression patterns could predict age in the general population. While this can only be done postmortem, and certain people will not fi t neatly into these patterns, it does provide scientists one more tool to understand how aging in the brain may be linked to the causes of age-related disorders. The team of researchers' ultimate goal is to see whether gene mutations or other variables could aff ect gene expression in ways that cause disease.

Materials for this article were provided by Cell Press. Cell Press is a leading publisher of cutting-edge biomedical research and reviews. They drive science forward and promote cross-pollination of ideas with our passion for excellence and commitment to innovation.

THE AGING BRAIN Glia, not neurons, are most aff ected by brain aging

FOREFRONT


FOREFRONT

Certain glia gene expression patterns could predict age in the general population.


CENTROPHENOXINE, (PRONOUNCED, CENT, ROW-FEN, OX-IN) IS A CLASSIC ‘SMART DRUG’

The term ‘smart drugs’ has becomesynonymous with substances thataid memory and cognition althoughthe correct medical terminology is‘nootropics’ (which when translatedfrom Greek is – ‘towards the mind’).Centrophenoxine is an ester of PCPA (aplant compound) and DMA which is anatural choline-based substance foundin the diet.

About Centrophenoxine

Centrophenoxine has been studied over decades. Principally in Europe and one of its leading experts is Professor Imr Zs-Nagy. He said, “Centrophenoxine has shown many facets to improve conditions related to my membrane hypothesis of aging. For example, its ability to improve brain performance, survival time in animal experiment and to remove the cell-aging pigment called lipofuscin. It has been my anti-aging supplement for more than 30 years.”

Centrophenoxine improves acetylcholine levels in the brain. It is this neurotransmitter that declines in Alzheimer’s disease. The target is at the early stage of dementia or even before then at the anti-aging stage, wherein smart drugs like centrophenoxine improve/enhance and protect the performance of an aging but otherwise recognised as a healthy individual.

Lipofuscin is a waste material that accumulates in aging cells especially those in the brain, heart, lungs and skin. In skin cells, Lipofuscin can form part of the pigmented spots that are often referred to as ‘age or liver spots’. Lipofuscin accumulation can be very troublesome for the cell because it inhibits proper functioning taking place, reducing the transference of chemicals through cell walls thus damaging both messaging and detoxifi cation abilities. When there are signifi cant amounts of Lipofuscin present in the brain they are then referred to as ‘plagues’ and then become a recognised trait of Alzheimer’s.

Centrophenoxine’s primary mode of action is to help remove lipofuscin deposits. Patients that take Centrophenoxine possibly over a couple of weeks can see aging spots fade or disappear. Whilst knowing, at the same time, Lipofuscin is reducing in their heart, lungs and brain.

General cognitive benefi ts

further evaluation. Which of the following is your issue?

Short term memory

Medium term memory

Long term memory

Do you get bored easily?

Do you lack focus/attention?

Does your mind quickly become tired?

Is the problem remembering new experiences?

Does it take you too long to recall memories?

Centrophenoxine is best suited to the last one. It can help people especially those over 40 to hasten their recall speed, bringing clarity and order to both speech and thought. A typical dose for the average person is 250mg once or twice daily.

CENTROPHENOXINE

SPOTLIGHT

13AGINGMATTERS

DEPRENYL FOR FOCUS AND CONCENTRATION

Deprenyl is also known as selegiline, it was created in the 1960s by Professor Joseph Knoll, principally as an aid to Parkinson’s patients - because deprenyl has a signifi cant benefi t to improve dopamine levels in the brain.

Signifi cant longevity studies

Professor Knoll’s experiments on rats produced incredible longevity benefi ts. When fed deprenyl in their food, they lived longer than those that were not. After the last non-treated rat died, the fi rst of the deprenyl treated rats hadn’t! These results were in another study conducted from research by, Dean, Fowkes and Morgenthaler - published in the book, ‘Smart Drugs and Nutrients’. It highlights that the loss of dopamine in humans with age, can be mapped against the development of Parkinson’s and even death.

Deprenyl has been expressed as a MAO-b inhibitor. Preventing the enzyme monoamine-oxidase type-b from destroying dopamine, ergo leading to its greater availability in the brain.

The inhibition of the more common MAO-a can be problematic, leading to something called ‘the cheese eff ect,’ not a side eff ect of deprenyl, although it should be noted that dopamine can inhibit type-a, usually at very high doses of 20mg. Professor Knoll has noted that there is another signifi cant action of deprenyl and this is the raising of PEA levels. PEA is a catecholamine activity enhancer that raises norepinephrine levels, it’s a signifi cant attention agent that is behind the primary mechanism of the famous Eugeroic drug- modafi nil (Provigil). Read Professor Knoll’s books - ‘The brain and its self’, or ‘How selegiline/ deprenyl slows brain aging.’

Typical patient responses

A patient who has mild cognitive impairment, or age related minor cognitive dysfunction, the most common report is a signifi cant improvement in their focus and concentration. Persons with higher dopamine levels often appear more ‘driven’ and ‘dedicated.’

Avoid overuse since it can lead to what may appear to be an oppressive behavior, as others around you are not so focused and ‘on the ball’ as you! We recommend breaks from deprenyl use.

Some advocate one week off in the month and others use it during the weekdays but not at the weekends.

Doses are based on need and age. Parkinson’s patients will require large doses. A person wanting to improve their cognitive performance may want to consider 1mg to 3mg per day, with occasional breaks. These doses do not take into account synergy with other dopamine enhancing agents and persons using anti-depressants should consult with their physician. Deprenyl tablets are provided in 5mg form (Jumex), some like to take ½ to 1 of these tablets 3-times a week. The use of the deprenyl liquid (Dep-Pro) is particularly attractive for those using deprenyl to generally support, protect and improve neurological function, since 1 drop = 1mg, the liquid can be dosed very precisely by placing those drops into a cold drink. Avoid use in the late evening to prevent any sleep disruption.

DEPRENYL

SPOTLIGHT


PIRACETAM, THE ORIGINAL NOOTROPIC

Smart drugs and nutrients, or to give them their correct medical terminology, nootropics are agents that can improve conditions of senile dementias and have become popular for older individuals to improve their mental and cognitive processes. It was Ward Dean, M.D. who highlighted these facts through his very popular ‘Smart Drug’ series of books in the 1980s, since then the term ‘smart drugs’ has become mainstream.

Piracetam, the original nootropic

This smart drug was fi rst developed by Dr. Giurgea for UCB laboratories in Belgium in the 1960s. Originally it was designed to assist with travel and altitude sickness, but shortly afterwards individuals realised that piracetam had positive cognitive enhancement eff ects.

Piracetam is a cognition agent that has been used successfully to treat a wide range of conditions, for example, it has been shown to increase a person’s attention levels and improve memory and intelligence. Piracetam can help to slow down ‘senile involution’, dementia and Alzheimer’s disease. In tests and trials, piracetam induces signifi cant improvement to memory consolidation and recall in those suff ering from ‘age-associated memory impairment’. It has also been used to improve patient’s recovery from strokes, particularly improving post stroke speech impairment (aphasia). Another use has been in cases of acute and chronic cerebral ischaemia, (decreased blood fl ow to the brain). Using piracetam has restored speech and the use of limbs in these patients; it has also increased neuronal activity in the brain when measured with EEG.

For regular individuals, piracetam has been shown to enhance idea creation and the ability to ‘see things through’. The level of clarity piracetam creates is often described, “the fog has lifted.”

How does piracetam work?

Piracetam’s key and unique method of action is upon the Corpus Callosum, the region of the brain that links the two hemispheres. Most experts believe it is the key that gives piracetam users the ability to channel greater brain potential by connecting the logical side of the brain with the creative side more eff ectively.

What are the doses of piracetam? A common dose is 800mg tablets three times a day, then lowering to 800mg twice a day after the fi rst month. The eff ects of piracetam can be enhanced if taken concurrently with centrophenoxine or Hydergine. Side eff ects are minimal and seldom experienced, but should you experience nausea or a headache then it is usually caused by an overdose. In which case reduce the dose and build up more slowly.

PIRACETAM

SPOTLIGHT

15AGINGMATTERS

BECAUSE NOT ALL MELATONINS ARE CREATED EQUAL

Melatonin is produced by the pineal gland at night to regulate our circadian rhythm, (sometimes called the sleep wake cycle). As we age the amount of melatonin we produce reduces, resulting in many older people sleeping less and having a lower quality of sleep. Our melatonin has been formulated by the world’s foremost melatonin expert Dr. Walter Pierpaoli, his Melatonin Zn Se, or MZS, is totally unique since it is designed to mimic the natural night peak of melatonin to leave you feeling refreshed and alert the following day.

What does Melatonin do?

Melatonin is vital to protect our hormonal system, regulate immunity and repair our body’s cells. Commonly used by shift workers and to treat jet lag and age related sleep disorders. Melatonin is an extremely eff ective antioxidant, in fact on a molecule to molecule basis - melatonin has proved to be signifi cantly more effi cient in neutralizing toxic hydroxyl radicals than the two wellknown free radical scavengers, glutathione and mannitol. Its eff ect on longevity is well documented. Experts believe melatonin has a positive eff ect on aging.

Age related macular degeneration (ARMD) comes in two forms, wet and dry. It’s a diffi cult disorder to treat and linked to blindness. A 24-month study, (published in NY Academy of Science, 2005, 1057:384-392) on 100 patients showed that after 3 months, the majority of patients taking 3 mg of Melatonin Zn Se nightly had halted the progression of their age related macular degeneration and at 6 months many showed reversal of their ARMD. True for both the wet and dry forms!

Why is Dr. Pierpaoli’s MZS more eff ective than other melatonin supplements?

Firstly, it is of pharmaceutical quality at a dose of 3 mg. Secondly, it contains the synergistic ingredients of selenium and zinc. Thirdly and most importantly- it is designed to release at a very specifi c time. Dr. Pierpaoli’s research led him to perfect a formula that exactly mimics the pineal gland’s release of melatonin. MZS is the only melatonin supplement to follow nature’s own night peak. Take half to one 3 mg tablet at bedtime only; do not take more than two tablets. By taking MZS™ between 9pm and 11pm you will create a night peak between 1am and 3am, this is the most natural and normal time to have the highest melatonin levels.

MZS is much more than a sleep aid and melatonin has many published benefi ts. MZS comes with the endorsement of Dr. Pierpaoli. If you’ve tried other melatonin and didn’t notice any signifi cant eff ect, then we highly recommend you try Dr. Pierpaoli’s MZS for a superior experience.

MZS

SPOTLIGHT


CATARACT & CAN-C™

17AGINGMATTERS

CAN-C

I t’s good news… Eye surgery is no longer the only option available if you suff er from conditions such as

cataracts, or blurred vision.

Can-C™ eye-drops give the opportunity to take control of various eye conditions. Helping to turn back the hands of time on what was once thought of as just being part and parcel of growing old, but can now in many cases be treated eff ectively, without the need for any invasive procedures at all.

Thanks to remarkable Russian research, Can-C™ eye-drops off er a genuine alternative to surgery. Now, cataracts can be treated simply by the daily use of eye-drops. Specifi cally designed for the treatment of senile cataracts and using a unique, patented formula containing the active and natural ingredient N-acetylcarnosine. Can-C™ eye-drops gently but eff ectively can slow, halt and even reverse the progress of cataracts. And the results are evident incredibly quickly. Even after just 1 month of treatment, the eff ects of Can-C™ eye-drops are clearly visible - breaking down the impaired proteins in the crystalline of the lens that cause the cataracts.

Cataract is the leading cause of blindness and accounts for about 42% of all such cases worldwide. More than 17 million people around the world are blind because of cataract and an alarmingly, 28,000 new cases are reported every day. Chronic, age-related visual problems such as cataract, macular degeneration and glaucoma have one basic similarity.

The non-surgical cataract treatment

CAN-C™

These are degenerative conditions caused by excessive oxidation (free radical damage-free radicals are toxic by-products of your everyday metabolism).

With aging, the production of these free radicals increases, whereas the body defences against them become less eff ective. Free radicals destroy proteins, enzymes and DNA causing chronic damage to tissues. A related process known as glycation is also strongly implicated; this process which conveniently abbreviates to AGE (advanced glycated end-products) is one where oxygen and glucose impair protein by cross-linking them.

Can-C™ is the original N-acetylcarnosine (NAC) eye-drop formula. The drops have been commercially sold since 2001 and in that time has helped many thousands of people treat their senile cataracts without the need for surgery. In fact, it is estimated that there have now been more than 50,000 documented patient cases of Can-C™ use.

CATARACT & CAN-C™

If you are frustrated with your eyesight, ask yourself these questions:

Are my eyes sensitive to light; or do I get cloudiness in parts of my vision?

Which problem do I deal with fi rst? My diffi culty driving at night, the overwhelming glare or my increased near sightedness?

When did this start happening to me? Is it stable or getting worse?

Why is this happening to me?

You could be the fi ttest person in the neighbourhood but your eyes may tell a diff erent story.

Everyone has their story. As we talk to customers all the time, they ask questions and we help to provide the answers.

WITH CAN-C™, YOU GET TO KEEP YOUR NATURAL LENS

Vision may be the most precious of our fi ve senses. Yet most of us take it for granted until it begins to deteriorate with age. Many thousands of patients using the eye-drops have noticed improvements of their vision, ranging from mild improvement to complete resolution of the condition. According to the manufacturers of Can-C™ lubricant eye-drops, with over half a million bottles sold worldwide. This means that many people have retained their natural lens and not needed to have it replaced by a plastic one. It should be obvious that a plastic lens does not have the optic accommodation and capacity of a natural one.

THE CATARACT EYE-DROP TREATMENT IS A PROVEN AND SCIENTIFIC ONE AND BASED ON CLINICAL EXPERIENCE

CAN-C

VISION IS PRECIOUS. PICTURES ARE WORTH A THOUSAND WORDS

So many times we hear people say, “My eyes aren’t what they used to be.” The simple fact is… they most probably aren’t. But that’s life, we get older and our bodies change. However, you don’t have to sit back and give up hope for improved vision.


19AGINGMATTERS

CAN-C

LOOK TO YOUR FUTURE WITH CLEARER VISION

The statistics in the human trials for Can-C™ show that N-acetylcarnosine eye-drops applied for 6-months twice daily into the eye, in patients, all suff ering from senile cataract, had the following results:

1. 88.9% had an improvement in glare sensitivity.

2. 41.5% had an improvement of the transmissivity of the lens.

3. 90% had an improvement in visual acuity. Note: You can also maximise the benefi t of using Can-C™ eye drops by taking Can-C™ Plus capsules. They are especially recommended in diffi cult cases, or for ripe cataracts (cataracts that have existed for a long time). So those who have very dense cataract and severely diminished vision to start with should combine the capsules with the eye-drops from day one.

The Can-C™ products can assist with lots of other eye conditions, such as:

• Dry eye syndrome

• Contact lens comfort (both as a lubricant and also because they block the painful accumulation of lactic acid which is caused by the contact lens rubbing onto the eye).

• Corneal disorders

• Computer vision syndrome

• Eye strain

• Ocular infl ammation

• Blurred vision

• Presbyopia

• Retinal issues

• Vitreous opacities and lesions

• Complications of diabetes mellitus and other systemic diseases

• Open-angle primary glaucoma

Can-C™ is a non-surgical cataract treatment. No risk, no large medical bills and no time off work! The reasons you should look after your eyes are many, especially when you consider the potential risks involved with surgery.

Some examples:

Can Can-C™ be taken in conjunction with other common eye supplements such as lutein and zeaxanthin / astaxanthin?

We do not recommend that the Can-C™ eye-drops are combined with lutein (unless a patient has a cataract associated with a retinal disorder), this is because lute-in appears to interfere with the same receptor sites as NAC and may lower the effi cacy of the eye-drops. You should stop taking lutein for at least the fi rst 6 months but after this period they may be started again. This is because Can-C™ does the majority of its restorative work in that period and thereafter it is maintenance, thus a reduced effi cacy is not so essential. The same is true for zeaxanthin; however we are not aware of contraindications with astaxanthin.

How long has Can-C™ been available?

Can-C has been sold since 2001 and in that time has helped thousands of people treat their senile cataracts without surgery.

Are there any problems using Can-C™ concurrently with other eye-drops for glaucoma pressure control? Would you recommend use of both?

To date, there have been no noted contraindications or side eff ects noted with the use of other eye-drops combined with Can-C™, but naturally, as there are so many versions, not all eye-drops have been tested along with the same. Dr. Mark Babizhayev (the inventor of the technology) has stated that beta blocker eye-drops used for glaucoma may actually have additional benefi t when combined with Can-C™ to help further reduce the intraocular pressure.


LONG TERM CATARACT SURGERY COMPLICATIONS

Long term cataract surgery problems and complications are those that we will defi ne as occurring from one week to as long as six months after cataract surgery.

Decentered or dislocated intraocular lens implant (IOL) - the artifi cial lens implant (IOL) used to correct your vision after cataract surgery can move slightly becoming decentered or move a greater amount and become dislocated.

Cystoid macular edema - during the fi rst three months or so after cataract surgery it is possible for the macula, the visual center of the retina, to be susceptible to microscopic swelling.

Secondary or after cataract - the most common complication of cataract surgery is opacifi cation of the posterior lens capsule resulting in the formation of a secondary cataract, which occurs after as many as 30% of cataract surgery procedures. When this occurs you will experience a gradual blurring of your vision. Here, the surgeon uses a YAG laser to perform a procedure called a YAG laser capsulotomy in which a small opening is created in the cloudy membrane.

KNOWLEDGE IS POWER

“Life begins at 40 – but so do fallen arches, rheumatism, faulty eyesight, and the tendency to tell a story to the same person, three or four times.” - Helen Rowland

ADDITIONAL READING ON THIS TOPIC

Dr. Mark Babizhayev is one of the principal Russian researchers behind the development and use of N-acetylcarnosine or NAC eye-drops. In his interview, he discusses with Phil from International Anti-Aging Systems (IAS) some of the results of his research.

Read the whole interview here: www.antiaging-systems.com/articles/172-interview-with-mark-babizhayev-phd-about-the-development-of-can-c-eye-drops

SHORT TERM CATARACT SURGERY COMPLICATIONS

Cataract surgery may be the most performed surgical procedure in the world, but it is not without its problems and complications – for example, 24 hours after surgery the following can occur:

• Bleeding - inside the back of the eye and inside the front of the eye where the actual surgery is being performed.

• Bruise or ‘black eye’ - if it was necessary to use an injection around your eye you may experience some temporary bruising.

• Wound or incision leak - sometimes the corneal incision does not seal properly and may leak.

• Endophthalmitis or ‘inner eye infection’ - an infection after cataract surgery is rare but can occur.

• Rupture of the posterior capsule - during cataract surgery, the cloudy or opacifi ed lens material is ‘chopped up’ and suctioned to remove it from the eye. Occasionally it is possible that the posterior lens capsule will tear or rupture during surgery.

• Retinal detachment - if you are extremely near-sighted you may be at greater risk for retinal detachment in general and especially when you have any type of eye surgery including cataract surgery.

• Glaucoma - in general, secondary Glaucoma after cataract surgery is very unusual. However, if there is other bleeding or infl ammation it can predispose the development of secondary Glaucoma.

• Signifi cant astigmatism - in the event that it was necessary to use sutures or stitches- because the corneal incision did not seal properly, it is possible to distort the shape of the cornea and induce astigmatism.

CAN-C

This is just an overview of the possible complications of cataract surgery. Of course, none of the information provided here is meant to be a substitute or replace your physician’s consultation nor does it replace the need for you to consult with your surgeon about specifi c details of cataract surgery complications.


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Can-C™ Plus is the perfect accompaniment to Can-C™ Eye Drops.

Maximise the benefi t from day one of the Can-C eye-drops. Those who have very dense cataract and severely diminished vision to start with should combine the tablets with the eye-drops from day one.

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PEOs

23AGINGMATTERS

W hen it comes to nutrition, there’s often a fair amount of controversy and confusion concerning

research on a particular food ingredient or dietary supplement. For example,health-conscious consumers want to know: Should we drink coff ee or tea? Or red wine? Eat dark chocolate? Use margarine instead of butter? How about omega-3 and omega-6 essential fatty acids (EFA’s - the topic of this article): what are they exactly, which ones do we need, and should we get them from fi sh oil or plants? Observing the plethora of health issues in our modern world that still remain unresolved despite the supposed promise of fi sh oil supplements, Brian Peskin, engineer and founder of Life-Systems Engineering Science has focused his recent career on getting to the bottom of the plant versus fi sh fatty acids controversy by thoroughly examining the medical literature, including results of countless studies.

His verdict: discard the fi sh oil capsules, obtain high quality omega-3 and omega-6 EFA’s (which Peskin has re-labeled “Parent Essential Oils,” or “PEO’s”) from plant-based sources, and enjoy myriad health benefi ts as a by product.

In this article, we’ll clear up the confusion about EFA’s (in fact, we’ll see that fi sh oil supplements technically don’t contain EFA’s at all!) by examining the chemical defi nition of “essential fatty acids;” their functions and health benefi ts; general misconceptions and proven facts concerning EFA’s; the plants versus fi sh oil debate; and how to incorporate these essential nutrients into your daily health regimen.

The “Real” Essential Fatty Acids, Demystifi ed

PEOs

PEOs


Let’s start out by precisely defi ning “essential fatty acid.” (But we’ll need to look at some chemistry, so please stick with me.) EFA’s are long-chain polyunsaturated fatty acids (PUFA’s), which means they are chains of multiple carbons (18 or more) containing more than one double bond. They are classifi ed as “essential” because they cannot be synthesized in the body and must be obtained from the diet.

ESSENTIAL FATTY ACIDS 101

Figure 1b. Structures of fatty acids

The chemical structure of α-linolenic acid (ALA) has 18 carbon atoms (C) and 3 double bonds, the fi rst of which is located 3 carbon atoms from the terminal methyl group (omega [ω] end)

Figure 1a. Structures of fatty acids

The general structure of a fatty acid (20)

HC 3 HC COOHHC 2(n)

hydrocarbonchain

carboxyl end

PEOs

EFA’s and other PUFA’s are named according to the position of the fi rst double bond in the carbon chain: in omega-6 fatty acids, the fi rst double bond is located between the sixth and seventh carbon atoms from the methyl end of the fatty acid, and in omega-3’s, the fi rst double bond is located between the third and fourth carbon atom from the methyl end. Fatty acid chains are not straight, but rather are crimped due to the presence of double bonds (as shown in Figure 1c).

The two — and only two — EFA’s are alpha-linolenic acid (ALA, an omega-3) and linoleic acid (LA, an omega-6), both containing 18 carbons. They are called “parent” compounds because they are the starting materials, or precursors, that the body uses to manufacture other longer-chain fatty acids (called “derivatives” or “metabolites”) with 20 or more carbons. For example, humans can synthesize longer-chain omega-6 fatty acids, such as dihomo-γ-linolenic acid (DGLA; 20 carbons) and arachidonic acid (AA; 20 carbons) from LA, and longer-chain omega-3 fatty acids, such as eicosapentaenoic acid (EPA; 20 carbons) and docosahexaenoic acid (DHA; 22 carbons) from ALA.

PEOs

25AGINGMATTERS

Both parent compounds, or EFA’s, are found in plant sources: LA in leafy vegetables, seeds, nuts, grains, and vegetable oils (such as evening primrose oil, as well as in less desirable processed vegetable oils, such as corn and sunfl ower oils); and ALA in fl axseed, hemp, canola, soybeans and walnuts. Omega-3 fatty acid derivatives EPA and DHA, as mentioned, are synthesized endogenously from ALA, but can also be derived from cold water oily fi sh such as salmon, herring, mackerel, sardines and albacore tuna; they are also the major components in fi sh oil supplements (which we’ll discuss in more detail later).

Figure 1c. Structures of fatty acids

The molecular stuctures of dietary omega-6 and omega-3 fatty acids. The presence of a double bond in the hydrocarbon chain of polyunsaturated fatty acids (PUFA) introduces a “kink” in the molecule, creating different secondary structures that infl uence physical properties(5).

Figure reference: http://lpi.oregonstate.edu/mic/other-nutrients/essential-fatty-acids

So, by defi nition, there are only two essential fatty acids: ALA (parent omega-3) and LA (parent omega-6), both of which are plant-derived nutrients that must be obtained from the diet. Not only are they important in the normal functioning of all tissues of the body, but they also act as precursors to other fatty acids.

PEOs


As mentioned, Brian Peskin has dedicated himself to the study of EFA’s; he’s pored over medical textbooks and relevant published journal articles to evaluate the health benefi ts of EFA derivatives (especially EPA and DHA) compared to parent compounds ALA and LA, and has made a determination in favor of the parents: he strongly advises against the use of derivative-containing fi sh oil supplements which may be ineff ective, even detrimental to health, and recommends supplementation with nature’s essential starting materials, parent omega-3 (ALA) and parent omega-6 (LA). Peskin has re-labeled these — the only two — essential fatty acids “Parent Essential Oils” (“PEO’s”), mainly to avoid the confusion over and misuse of the term “EFA,” which is sometimes misleadingly or mistakenly applied to derivatives. For example, a Google search of “EFA’s” reveals many inappropriately labeled products on the market which are, in fact, derivative-containing fi sh oil capsules, like this one: [manufacturer name excluded] “Mega EFA Omega-3 EPA & DHA Fish Oil” — what a mouthful, and wrongly labeled “EFA.”

For our discussion, since we’ve already reviewed precise chemical defi nitions, “PEO” will be used interchangeably with “EFA;” “ALA” with “parent omega-3;” and “LA” with “parent omega-6.”

It seems that when it comes to PUFA’s, the bulk of marketing and media emphasis has been unduly placed on derivatives (especially fi sh oil-derived EPA and DHA), not parents ALA or LA. Although derivatives provide an array of health benefi ts, parents are essential nutrients (remember, we are unable to synthesize them), and substantial published information supports their inclusion in a healthy diet. So why are parent omega-3 and parent omega-6 so important?

First, they play an integral role in the structure and function of the cell membrane, a thin lipid bilayer composed of two sheets of phospholipid molecules that form a continuous barrier around every cell (and we have 100 trillion of them) in the body.

PUFA: polyunsaturated fatty acid (EFA’s and derivatives are PUFA’s.)EFA = essential fatty acidPEO = parent essential oilEFA = PEO, of which there are only two:ALA = alpha-linolenic acid = parent omega-3LA = linoleic acid = parent omega-6

Some EFA derivatives:DGLA = dihomo-γ-linolenic acid (omega-6)AA: arachidonic acid (omega-6)EPA: eicosapentaenoic acid (omega-3)DHA: docosahexaenoic acid (omega-3)

Peskin has co-authored a book, along with Robert Rowen, MD, entitled “PEO Solution, Conquering Cancer, Diabetes and Heart Disease with Parent Essential Oils,” in which he outlines several interrelated facts as well as misconceptions concerning EFA’s and derivatives, which we’ll now discuss.

TECHNICALLY, PEO = EFA

NOT ENOUGH ATTENTION PAID TO PARENTS!

This membrane protects the cellular contents and internal machinery from the external environment while selectively allowing nutrients into, and waste products out of the cell. Research shows that fatty acids consumed in the diet become incorporated into the phospholipid bilayer and aff ect cell membrane composition and properties such as fl uidity, fl exibility, permeability, and enzyme activity.(1,2)

So a diet rich in saturated fat will result in cell membranes that are structurally diff erent and less fl uid than those that incorporate EFA’s(2) (and that’s just one good reason to make the switch to EFA’s!).

Besides membrane composition and function, EFA’s in the lipid bilayer also play a role in transporting oxygen, necessary for cellular respiration and other vital processes, into the cell.

ABBREVIATIONS:

An EFA defi ciency resulting in lower availability of oxygen for cellular respiration may lead to health consequences, and Peskin believes that insuffi cient cellular oxygenation (hypoxia) is the prime cause of cancer. Peskin refers to parents as “oxygen magnets” that can stem cancer and other disease processes. EFA’s also act as precursors to bioactive mediators such as eicosanoids (including prostaglandins, thromboxanes, leukotrienes, etc.), chemical messengers that play critical roles in immune and infl ammatory responses. They can also modulate the expression of various genes.

So we can see that parent compounds play many key cellular roles, despite the relative lack of popular and marketing emphasis compared with fi sh oil derivatives.

PEOs

27AGINGMATTERS

OMEGA-6 FATTY ACIDS NOT GIVEN THEIR DUE RESPECT

THE BODY ONLY PARTIALLY CONVERTS PARENTS TO DERIVATIVES, THAT’S ENOUGH

PEOs

It also appears that most of the popular attention has been placed on the supposed health benefi ts of the omega-3 series (especially derivatives), ignoring that unadulterated, high quality omega-6’s are also vital to good health. Omega-6 seem to have developed a bad reputation for a couple of reasons. The fi rst involves the LA metabolite arachidonic acid (AA), thought to contribute to pro-infl ammatory processes and heart disease. However, according to one researcher, “this perspective fails to consider several inconvenient facts(3)," such as that dietary intake of LA does not signifi cantly aff ect AA levels in the body(3,4). “Virtually no evidence is available from randomized, controlled intervention studies among healthy, non-infant human beings to show that addition of LA to the diet increases the concentration of infl ammatory markers(3)." Myth debunked.

Another reputation detractor concerns the quality of omega-6 in the typical Western diet, which is, in two words, largely adulterated (chemically altered). LA in commercial cooking oils is typically highly modifi ed in multi-step processes that include the use of solvents, high temperatures, and additives in order to hydrogenate or interesterify the fatty acids, resulting in products that last longer, but are dangerous to health, with adverse eff ects on cardiovascular health(4). But unadulterated LA-rich oils reduce risk of cardiovascular disease and should be consumed as part of a healthy diet(4), pointing to the need to eliminate hydrogenated vegetable oils and replace them with high quality oils such as saffl ower, sesame, and sunfl ower.

Even more so than saturated fat, Peskin believes that “the real culprits” responsible for the abundance of health problems in the modern world are highly processed, chemically altered fats, and that “good health requires a preponderance of [unadulterated, high quality] dietary parent omega-6,” with a higher ratio of omega-6 to omega-3 fatty acids. Ideally, this ratio should be between 1:1 and 4:1(5).

A medical fallacy concerning omega-3’s (that at least in part drives the success of the fi sh oil industry) is that ALA should ideally completely metabolize to EPA and DHA in the body, and that, since research has shown that conversion is limited in humans, then this must mean that most people are defi cient in these longer-chain derivatives. This naive assumption is repeatedly challenged in Peskin’s book, in which he states that the “body makes derivatives as needed,” with conversion rates set naturally low. Only 5% of ALA is metabolized to EPA and even less (less than 1%) to DHA(6). And for healthy individuals, these conversion rates should be suffi cient to maintain tissue function(7).

Consider that the net rate of DHA (the most abundant PUFA in the brain) consumed by the brain is only about 2 to 6 mg per day(8). This underscores the fact that, although the body needs a certain level of derivatives for proper functioning, our physiology does not depend on the mega doses of DHA and EPA that many doctors prescribe in the form of fi sh oil; in fact, as we’ll see in the next section, ultra-high doses of derivatives could be doing us harm. According to Peskin, EPA and DHA act as “biological antifreeze to fi sh living in frigid waters. Humans don’t require such copious amounts because we have an internal temperature of 98.6 degrees F.”

Interestingly, a study comparing the eff ects of dietary patterns on omega-3 PUFA status found that women on vegan diets actually had higher blood levels of long-chain omega-3’s compared with fi sh-eaters(9), which demonstrates that by adhering to a plant-based diet (rich in EFA’s), they manufactured ample DHA and EPA without consuming fi sh or fi sh oil.

References1. http://lpi.oregonstate.edu/mic/other-nutrients/essential-fatty-acids2. Hussein JS. Cell Membrane Fatty Acids and Health. International Journal of Pharmacy and Pharmaceutical Sciences.2013;5(3):38-46. 3. Harris WS, Shearer GC Omega-6 fatty acids and cardiovascular disease: friend, not foe? Circulation. 2014 Oct 28;130(18):1562-4. 4. Anton SD, Heekin K, Simkins C, Acosta A. Diff erential eff ects of adulterated versus unadulterated forms of linoleic acid on cardiovascular health. J Integr Med. 2013 Jan;11(1):2-10. 5. Simopoulos AP. Essential fatty acids in health and chronic disease. Am J Clin Nutr.1999;70:560S-569S.6. Rajaram S. Health benefi ts of plant-derived α-linolenic acid. Am J Clin Nutr. 2014 Jul;100(1):443S-8S. 7. Williams CM, Burdge G. Long-chain n-3 PUFA: plant v. marine sources. P Nutr Soc. 2006;65:42-50.8. Umhau JC, Zhou W, Carson RE, et al. Imaging incorporation of circulating docosahexaenoic acid into the human brain using positron emission tomography. J Lipid Res. 2009 Jul;50(7):1259-68. 9. Welch AA, Shakya-Shrestha S, Lentjes MAH, Wareham NJ, Khaw KT. Dietary intake and status of n-3 polyunsaturated fatty acids in a population of fi sh-eating and non-fi sh-eating meat-eaters, vegetarians, and vegans and the precursor-product ratio of a-linolenic acid to long-chain n-3 polyunsaturated fatty acids: results from the EPIC-Norfolk cohort. Am J Clin Nutr. 2010;92:1040-1051.

As just explained, the body metabolizes ALA to longer-chain EPA and DHA to a limited degree that is suffi cient to maintain normal tissue function, a fact that is often unrecognized, overlooked, or ignored as doctors prescribe excessive doses of fi sh oil in an attempt to improve cardiovascular and other health problems. This results in patients reaching supra-physiological blood levels of derivatives (dozens, even hundreds of times more than the body manufactures naturally, depending on the particular supplement and amount consumed), leading to unresolved or even exacerbated problems. Peskin argues that excess omega-3 derivatives end up in unusual places they don’t belong: skin, cardiovascular system, prostate, and breast tissue, where they can potentially lead to increased rates of prostate cancer, skin cancer, and heart disease. Recent large studies have in fact shown increased risk of prostate cancer in men with higher blood

Earlier, we took a glimpse at the important biological roles parent compounds play on a cellular level: as major constituents of cell membranes, as precursors to chemical messengers, and as transporters of oxygen into the cell. On a whole-body level, EFA’s are cardio-protective; prevent certain types of cancer; and benefi t normal brain development and function, infl ammatory disorders, and diabetes, with the added cosmetic eff ect of improving skin, hair, and nails. But in order to be eff ective, sources of EFA’s must be

OVER-ESTIMATION OF DHA AND EPA REQUIRMENTS LEADS TO FISH OIL OVERDOSING AND ITS CONSEQUENCES

MAKE THE SWITCH - YOUR HEALTH DEPENDS UPON IT

10. Brasky TM, Darke AK, Song X, et al. Plasma phospholipid fatty acids and prostate cancer risk in the SELECT trial. J Natl Cancer Inst. 2013 Aug 7;105(15):1132-41. 11. Roncaglioni MC, Tombesi M, Avanzini F, et al. n-3 fatty acids in patients with multiple cardiovascular risk factors. N Engl J Med. 2013;368:1800-1808.12. Rizos EC, Ntzani EE, Bika E, Kostapanos MS, Elisaf MS. Association between omega-3 fatty acid supplementation and risk of major cardiovascular disease events: a systematic review and meta-analysis. JAMA. 2012;308:1024-1033.13. Kwak SM, Myung SK, Lee YJ. Effi cacy of Omega-3 Fatty acid supplements (eicosapentaenoic acid and docosahexaenoic acid) in the secondary prevention of cardiovascular disease: a meta-analysis of randomized, double-blind, placebo-controlled trials. Arch Intern Med. 2012;172:986-994.14. Chew EY, Clemons TE, Agrón E, Launer LJ, Grodstein F, Bernstein PS; Age-Related Eye Disease Study 2 (AREDS2) Research Group. . Eff ect of Omega-3 Fatty Acids, Lutein/Zeaxanthin, or Other Nutrient Supplementation on Cognitive Function: The AREDS2 Randomized Clinical Trial. JAMA. 2015 Aug 25;314(8):791-801.

levels of long-chain omega-3 derivatives (but reduced risk of cancer with higher parent omega-6 (LA) levels(10)).

And although a large body of scientifi c research suggests that higher omega-3 fatty acid intake is associated with reductions in cardiovascular disease risk, other recent studies in the New England Journal of Medicine(11), Journal of the American Medical Association(12), and Archives of Internal Medicine(13) fi nd the opposite: fi sh oil derivatives do not improve cardiovascular risk factors. (However, parent omega-3 (ALA) does lower the risk of heart disease(6), as does parent omega-6 (LA)(4).)

Nor does fi sh oil slow cognitive decline, as was previously thought. A large study performed at the National Eye Institute/National Institutes of Health tested the eff ect of various supplements, including omega-3’s, on cognitive function in over 3500 subjects (average age 73) and found no statistically signifi cant eff ect(14).

We can only conclude that fi sh oil is not all it’s cracked up to be.

organic and unprocessed and in the correct physiologic ratio. A plant-rich diet that includes ample amounts of natural foods such as ground fl axseeds, walnuts, leafy vegetables, seeds, nuts, and unprocessed vegetable oils will provide more than the necessary daily requirements for EFA’s. However, for those whose diets fall short, Peskin has formulated a product called PEO-Pro™ containing organic, unprocessed ingredients: evening primrose oil, sunfl ower oil, fl ax oil, pumpkin oil, and extra-virgin coconut oil, in a ratio of approximately 2:1 omega-6: omega-3. The recommended dose is four capsules per day, which provides

almost 3g of EFA’s. We have just seen the “power of the parents” and hopefully unraveled the myths and cleared up the misconceptions concerning EFA’s and their derivatives. To sum up, here’s the ideal way to meet your requirements for these essential nutrients: eliminate both fi sh oil capsules and highly processed vegetable oils (and, for that matter, any processed foods) and replace them with plant-based sources of high quality, organic parent omega-3 (ALA) and organic, unprocessed parent omega-6, (LA) in the proper ratio. Enjoy vibrant health as a result.

PEOs



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RETIN-PRO™

31AGINGMATTERS

RETIN-PROTM

W hen you picture aging, what is the fi rst thing that comes to mind? Most likely it's

wrinkles, lines, furrows and sagging skin - the external manifestations of growing older. As the skin is the largest and the outermost organ of the body, it’s the most subject to the damaging eff ects of the environment. The skin is unique in that it undergoes aging both from the inside, as a result of a genetically programmed clock, and from the outside, due to environmental

THE ‘GOLD STANDARD’ TREATMENTS TO REVERSE SKIN WRINKLES

RETIN-PRO™

Skin is a complex organ comprising various structures and cell types that play a variety of roles, including protection from the environment, heat regulation, immune response, water and electrolyte balance, among others.(1) Skin aging is a complicated biological process resulting from what scientists call intrinsic (internally produced) and extrinsic (external) factors. Intrinsic, or chronological, skin aging is infl uenced by genetics, hormonal changes, smoking, illness, and the generation of reactive oxygen and nitrogen species as by products of routine metabolism.(1-3) Extrinsic factors that age skin include environmental exposure to DNA-damaging agents such as UV radiation from sunlight, pollution, and smoke.(1-3) By far, solar UV radiation is the single most destructive element responsible for prematurely aged skin(1,4,5). Intrinsic skin aging that occurs simultaneously with chronic UV exposure is known as photoaging - a combination age-accelerating process that alters the skin’s structure, function and appearance.

WHAT CAUSES SKIN TO AGE?

exposure, particularly UV radiation from sunlight. The eff ects of chronic sun exposure overlaid on the background of chronological aging are a sure predictor for pre maturely aged skin.

The good news is that a huge trove of clinical studies performed over the last 25 years indicates that the detrimental aging-induced structural and cosmetic skin changes compounded by cumulative UV radiation can be improved, and even reversed, by the topical use of vitamin

A derivatives known as retinoids. In particular, we’ll look at one of these analogs, tretinoin, the active ingredient in Retin-Pro™ cream and micro-gel. Tretinoin is the most widely investigated and possibly the most potent retinoid to treat the combined eff ects of the internal and external assaults to the skin.


RETIN-PROTM

With increasing age, the skin’s rejuvenation process slows down and skin loses its suppleness and thickness due to atrophy of the epidermis (the outer layer of skin) and degradation of the dermal extracellular matrix(1) - the portion of skin tissue other than cells that is fi lled by a variety of fi brous proteins including collagen, elastin and fi brillin, and polysaccharides known as glycosaminoglycans. These components network to form an organized, intricate structural framework that gives the skin its elasticity, density and strength. Loss of these support macromolecules leads to the thin, dry and saggy appearance characteristic of chronologically aged skin.

WHAT ARE THE DIFFERENCES BETWEEN PHOTOAGED AND CHRONOLOGICALLY AGED SKIN?

We’ve already seen that one aspect of intrinsic aging is increased oxidative stress due to the generation of reactive oxygen species (ROS) that damage skin (as well as internal organs and tissues). In photoaged skin, repeated exposure to sunlight sets off a chain reaction accelerating ROS production even further, altering gene and protein structure and function and decreasing endogenous antioxidant enzymes.(1)

In addition, UV radiation triggers biochemical pathways associated with infl ammation, decreased immune response and further degradation of the epidermis and dermal extracellular matrix,(1,3,6) including collagen, elastin and fi brillin loss.(7,8)

These damaging processes lead to photoaged skin with a yellowish appearance, fi ne and coarse wrinkles, mottled and abnormal pigmentation (“age spots”), and roughness.(1,2;7-10) In addition, due to the DNA-damaging eff ects of the sun, photoaged skin is prone to the development of precancerous and cancerous skin lesions (1,11). (These features of photoaging are more common in white compared with other skin types(2)) So although they share some similar features such as wrinkles and loss of skin thickness, chronologically and photoaged skin do have somewhat diff erent presentations.

A variety of methods, including surgery, can improve the appearance of photoaged skin, but the only therapy that has stood the test of extensive clinical trials, validating their effi cacy in repairing the dermal extracellular matrix and ameliorating signs of photodamage is the use of topical retinoids. The retinoid family comprises vitamin A (retinol) and both its natural metabolites, including tretinoin, as well as synthetic derivatives. Retinoids are required for a vast number of biological processes including embryogenesis, reproduction, vision, immune modulation,(1) and most importantly for our discussion, cellular growth and diff erentiation and the activation of the skin’s repair mechanisms(1).

TRETINOIN IS THE ‘GOLD STANDARD’ TOPICAL RETINOID TO REVERSE PHOTODAMAGE

RETIN-PROTM

Topical retinoids are eff ective, safe, and even essential in the treatment and prevention of photo-damaged skin, and were fi rst introduced for this purpose about 30 years ago.

In the body, retinol is metabolized to several important products including tretinoin, the carboxylic acid analog, also known as all-trans retinoic acid. Tretinoin has been used as a topical therapy for acne, psoriasis, skin cancer, and burns and, as mentioned, may be the most potent retinoid in the treatment of photoaging.(1) It is considered the ‘gold standard’ prescription topical remedy for improving, even reversing, the fi ne and coarse wrinkles, sallowness, pigment abnormalities, and roughness associated with photoaging.

33AGINGMATTERS

RETIN-PROTM

Studies show that topically applied tretinoin increases epidermal proliferation,(1) promotes the synthesis of glycosoaminoglycans (a source of hydration that when absent results in a dull, leathery appearance),(12) blocks infl ammation mediators,(6) and restores the collagen and fi brillin-rich network of the dermal extracellular matrix(6,8) present in youthful skin. In addition, tretinoin “primes” the skin to prevent further

HOW TRETINOIN RESCUES PHOTODAMAGED SKIN

The fi rst study demonstrating the ability of topical tretinoin to induce collagen production and eliminate wrinkles was performed on the photoaged skin of mice in 1984.(14) Then, in 1986, encouraging results from the fi rst clinical trial on human photodamaged skin(15) spurred a considerable number of studies. Short-term double-blind trials of three, four and six months conducted in the late 1980’s and early 1990’s using various strengths of topical tretinoin cream (typically including the standard therapy of 0.05% tretinoin) showed statistically signifi cant improvement in several features of photoaging, including wrinkles, roughness, sallowness, and abnormal pigmentation. As an added benefi t, the improved appearance of the skin was accompanied by a ‘rosy glow.’(16-21)

Subsequent long-term studies were performed to evaluate the eff ects of continued tretinoin application over months or years. A 1993 study evaluating 0.05% tretinoin cream applied daily for 12 months showed that the major degree of improvement in the signs of photoaging occurred after six months of use, a trend that continued over time.(22) Histological (tissue) studies confi rmed that observation. By month 12 of daily tretinoin application, there was an increase in collagen fi bers, a reduction of degenerated microfi brillar material,(23) renewed epidermal thickness and a return to normal pigmentation.(24) A more recent 2005 two-year study corroborated these earlier results. Both visual and histological improvements to skin were achieved in patients with moderate to severe photodamage by month 12 of daily 0.05% tretinoin application.(25)

NUMEROUS STUDIES DOCUMENT TRETINOIN’S REMARKABLE AGE-REVERSAL EFFECTS

matrix degradation by UV, in this way preventing future skin photoaging(6,9,13). Tretinoin’s tissue-restoring eff ects are mediated by the binding to and activation of specifi c receptors present in skin, known as nuclear retinoid receptors,(1,6,7) that are involved in gene expression, protein synthesis, and cell growth and diff erentiation and provide the mechanisms necessary for the repair of photodamaged skin(1).

Even those who have taken precautions to avoid the damaging eff ects of the sun will gladly welcome emerging evidence that topical tretinoin may also benefi t intrinsically aged skin.(1,9,13) A study on the daily application of 0.025% tretinoin cream on chronologically aged inner thigh skin for nine months showed signifi cant improvement at the tissue level,(26) suggesting that tretinoin has wide implications in the treatment of both photoaged and chronologically aged skin.

Although topical tretinoin produces marked improvement, even reversal, of wrinkles and other signs of photoaging, skin sensitivity may occur in some individuals, including dryness or scaling, irritation and redness. The occurrence and magnitude of these reactions seem to depend on concentration, frequency of use, product base (cream or gel) and individual variations.(27)

To address the issue of skin sensitivity, several trials were conducted to determine the effi cacy and tolerability of a low strength cream, between 0.02-0.025% tretinoin. Researchers observed signifi cant improvements in the visual and histological signs of photoaging along with good tolerability and fewer instances of adverse eff ects,(28-30) even with long-term use.(28,30)


Apply a small amount to thoroughly cleansed and dry skin in the evening and avoid contact with the eyes, corners of the nose, and mouth. The use of a daily moisturizer such as NeySkin® is recommended (if moisturizer is used in the evening, wait 30 minutes after applying Retin-Pro™). Tretinoin can cause photosensitization, or increased sensitivity to sun. Avoid sun exposure and use a quality sunblock or sunscreen, such as Solaris®, and wear protective clothing. Also avoid weather extremes such as wind and cold, if possible.

HOW TO USE RETIN-PRO™

References1. Mukherjee S, Date A, Patravale V, Korting HC, Roeder A, Weindl G. Retinoids in the treatment of skin aging: an overview of clinical effi cacy and safety. Clin Interv Aging. 2006;1(4):327-48.2. Manríquez JJ, Majerson Gringberg D, Nicklas Diaz C. Wrinkles. Clin Evid (Online). 2008 Dec 16;pii: 1711.3. Kaczvinsky JR, Bertucci V, Fu JJ. Practical application of genomics to the development of a topical cosmetic anti-aging regimen. Skin Therapy Lett. 2011 Jul-Aug;16(7):4-7.4. Rittié L, Fisher G. UV-light-induced signal cascades and skin aging. Aging Res Rev. 2002;1:705–20.5. Darlenski R, Surber C, Fluhr JW. Topical retinoids in the management of photodamaged skin: from theory to evidence-based practical approach. Br J Dermatol. 2010 Dec;163(6):1157-65.6. Kang S. The mechanism of action of topical retinoids. Cutis. 2005 Feb;75(2 Suppl):10-3; discussion 13.7. Ogden S, Samuel M, Griffi ths CE. A review of tazarotene in the treatment of photodamaged skin. Clin Interv Aging. 2008;3(1):71-6.8. Watson RE, Ogden S, Cotterell LF, et al. Eff ects of a cosmetic ‘anti-ageing’ product improves photoaged skin [corrected]. Br J Dermatol. 2009 Aug;161(2):419-26. Epub 2009 Apr 28.9. Singh M, Griffi ths CE. The use of retinoids in the treatment of photoaging. Dermatol Ther. 2006 Sep-Oct;19(5):297-305.10. Samuel M, Brooke RC, Hollis S, Griffi ths CE. Interventions for photodamaged skin. Cochrane Database Syst Rev. 2005 Jan 25;(1):CD001782.11. Stratigos AJ, Katsambas AD. The role of topical retinoids in the treatment of photoaging. Drugs. 2005;65(8):1061-72.12. Griffi ths CEM, Finkel IJ, Tranfaglia MG, et al. An in-vivo experimental model for topical retinoid eff ects on human skin. Br J Dermatol. 1993;29:389–99.13. Serri R, Iorizzo M. Cosmeceuticals: focus on topical retinoids in photoaging. Clin Dermatol. 2008 Nov-Dec;26(6):633-5.14. Kligman LH, Chen HD, Kligman AM. Topical retinoic acid enhances the repair of ultraviolet damaged dermal connective tissue. Connect Tissue Res. 1984;12:139–50.15. Kligman AM, Grove GL, Hirose R, et al. Topical tretinoin for photoaged skin. J Am Acad Dermatol. 1986;15:836–59.16. Weiss JS, Ellis CN, Headington JT, et al. Topical tretinoin improves photoaged skin: a double-blind vehicle-controlled study. JAMA. 1988;259:527–32.17. Lever I, Kumar P, Marks R. Topical retinoic acid for treatment of solar damage. Br J Dermatol. 1990;122:91–8.

18. Leyden JJ, Grove GL, Grove MJ, et al. Treatment of photodamaged facial skin with topical tretinoin. J Am Acad Dermatol. 1989; 21:638–44.19. Caputo R, Monti M, Motta S, et al. The treatment of visible signs of senescence: the Italian experience. Br J Dermatol. 1990;122 (Suppl35): 97–103.20. Weinstein GD, Nigra TP, Pochi PE, et al. Topical tretinoin for treatment of photodamaged skin. Arch Dermatol. 1991;127:659–65.21. Bhawan J, Gonzalez-Serva A, Nehal K, et al. Eff ects of tretinoin on photodamaged skin. A histologic study. Arch Dermatol. 1991;127:666-72.22. Green LJ, McCormick A, Weinstein GD. Photoaging and the skin: the eff ects of tretinoin. Dermatol Clin. 1993;11:97–105.23. Bhawan J, Palco MJ, Lee J, et al. Reversible histologic eff ects of tretinoin on photodamaged skin. J Geriatr Dermatol. 1995; 3:62-7.24. Bhawan J, Olsen E, Lufrano L, et al. Histologic evaluation of the long-term eff ects of tretinoin on photodamaged skin. J Dermatol Sci.1996;11:177–82.25. Kang S, Bergfeld W, Gottlieb AB, et al. Long-term effi cacy and safety of tretinoin emollient cream 0.05% in the treatment of photodamaged facial skin: a two-year, randomized, placebo-controlled trial. Am J Clin Dermatol. 2005;6(4):245-53.26. Kligman AM, Dogadkina D, Lavker RM. Eff ects of topical tretinoin on the non-sun exposed protected skin of the elderly. J Am Acad Dermatol. 1993; 29:25–33.27. Leyden JJ, Grossman R, Nighland M. Cumulative irritation potential of topical retinoid formulations. J Drugs Dermatol. 2008 Aug;7(8 Suppl):s14-8.28. Griffi ths CEM, Kang S, Ellis CN, et al. Two concentrations of topical tretinoin (retinoic acid) cause similar improvement of photoaging but diff erent degrees of irritation. Arch Dermatol. 1995;131:1037–44.29. Nyirady J, Bergfeld W, Ellis C, et al. Tretinoin cream 0.02% for the treatment of photodamaged facial skin: A review of 2 double-blind clinical trials. Cutis. 2001;68:135–42.30. Kircik LH. Safety and effi cacy evaluation of tretinoin cream 0.02% for the reduction of photodamage: a pilot study. J Drugs Dermatol. 2012 Jan;11(1):83-90.31. Weiss JS, Shavin JS, Nighland M, Grossman R. Tretinoin microsphere gel 0.1% for photodamaged facial skin: a placebo-controlled trial. Cutis. 2006 Dec;78(6):426-32.

RETIN-PROTM

As we have just seen, the synergistic eff ects of chronological aging compounded with chronic sun exposure can wreak havoc on the skin. Despite an array of techniques and products claiming to eff ace wrinkles, only retinoids have undergone the battery of clinical trials necessary to clearly establish their effi cacy in reversing the damaging processes involved in photoaging. One retinoid in particular, tretinoin, is the most thoroughly investigated of its class and considered the “gold standard” therapy for treating and reversing wrinkles, age spots, roughness and sallowness.


RetinPRO™

Tretinoin 0.05% Cream, 30ml pump $34.99 (usual price $39.99)

Retinolic Acid for treatment of skin wrinkles


ONLINE VOUCHER: RETIN-5-OFF-0117

All side eff ects and contraindications are available on the IAS website.


ESNATRI AND PROGESTERONE

BIOIDENTICAL HORMONES - NATURAL ESTROGENS AND PROGESTERONE FOR WOMEN

In this featured section we are focusing on the use of natural estrogens and progesterone for women, normally utilised to aid the menopause. IAS carries a wide range of bioidentical hormones - a term that means ‘natural to and in the body’.

When hormone replacement therapy (HRT) was developed in the 1920s, estrogens had to be derived from horse urine because a laboratory solution was too diffi cult or expensive to synthesize. Facts pointed out by Dr. Wright in his best-selling book ‘Stay Young & Sexy’. Estrogens can be easily produced now. Some people believe that the known side-eff ects from ‘traditional HRT’ are due to the fact that the hormones given are not correct.

Introducing Esnatri

Esnatri is our bioidentical triple estrogen cream. One of the best bioidentical estrogen creams available. It comes directly from the work of Dr. Wright who has shown that the majority of women produce estrogens in the ratios of 90% estriol, 7% estradiol and 3% estrone.

Most tri-estrogen preparations attempt to replicate the human hormones estriol, estradiol and estrone, apply them in the ratio of 80:10:10, while some even entirely over-look estriol, claiming it is a weak estrogen. But, women naturally produce high levels of estriol and it is considered to have anticarcinogenic eff ects.

The Esnatri cream can be applied by daily rotation to your neck, upper chest, breasts and behind the knees, or inner thighs. A typical starting dose is 2 mg. Start from day one (of what would have been the start of your menstrual cycle) and continue until day 25. You should stop for fi ve days, before repeating the application at the start of the next menstrual cycle. During these last few days, the estrogen receptors are being allowed to ‘rest’ as they have been accustomed.

Combing Estrogen with Progesterone

Progesterone is the counterbalance to estrogens. Women can signifi cantly decline in estrogen levels during menopause - they rarely reach zero production levels, whereas progesterone can sometimes not be measured at all in elderly women. It is also the low progesterone that most signifi cantly impacts bone strength, leading onto osteoporosis. There are numerous reasons to ensure that progesterone is also taken alongside an estrogen therapy. IAS provides a 5% strength natural progesterone cream. Typical doses are 25 mg to 30 mg of progesterone applied on day 10 and continuing to 25. The start date varies according to the usual timing of your ovulation. As with the Esnatri cream, stop for the last fi ve days of your cycle so that the estrogen receptors have their accustomed ‘rest’ period. Remember, your hormone replacement therapy should be overseen by a physician and should not be undertaken if you have undergone cancer treatment.

SPOTLIGHT

37AGINGMATTERS

SPOTLIGHTSPOTLIGHT

FOR THE HYPOTHYROID EPIDEMIC

Dr. Broda Barnes in the 1970s estimated that 40% of the adult population was defi cient in thyroid hormones. He published this statement in his excellent book - ‘Hypothyroidism, the unsuspected epidemic.’ Since then, pupils of Dr. Barnes, such as Dr. Richard Wilkinson, have suggested that this fi gure could be even greater now!

The thyroid gland is of pivotal importance to our overall health, as we age the production of thyroid hormones decline. This lack of thyroid function is the root cause of a variety of age related health disorders. Ergo, supplementation with a synthetic or a natural thyroid can have a signifi cant positive eff ect on a wide range of age related problems.

The importance of the thyroid gland

The hormones produced by the thyroid control the body’s metabolism- the rate at which it burns calories for energy. It controls the body’s utilization of fat, so a decline in the secretion of hormones from the thyroid gland, (known as hypothyroidism) can result in a range of symptoms such as poor concentration, confusion, memory problems, cold hands and feet and weight gain. Another serious condition which can be caused by and result from an underactive thyroid are painful musculoskeletal issues that aff ect tendons, muscles and ligaments. Your doctor can have your blood levels of thyroid checked. In addition to that, you can take your body temperature when you wake in the morning, it should be in the range of 97.8 to 98.2 degrees Fahrenheit. If it is regularly lower you could be hypothyroid and if higher then hyperthyroid.

Choosing between synthetic and natural thyroid supplements

IAS stocks a comprehensive range of both synthetic and natural thyroids, although we advocate the use of a natural supplement over a synthetic, this is because products such as Armour are of a porcine origin, so they naturally contain the full spectrum of T1, T2, T3 and T4 thyroid hormones, (note the bottles only list the amounts of T3 and T4 because very few physicians are familiar with T1 and T2).

Natural desiccated thyroids are measured in grains; with one grain being equivalent to approximately 60 mg. IAS carries doses from ¼ grain to 3 grains, with brands including Armour, ERFA and Nature. IAS also provides synthetic T3 in 20 mcg and T4 in 100 mcg tablets.

Thyroid supplements provide potent antiaging protection. Many aging individuals can benefi t from taking a thyroid supplement because this remarkable hormone has such a profound aff ect across so many diff erent conditions. Many antiaging physicians consider thyroid support an essential part of any serious attempt to improve a person’s health-span and longevity.

THYROIDSUPPORT


PEPTIDE BIOREGULATORS

39AGINGMATTERS


B ehind every great discovery, comes an interesting story and this one is a revelation, for it begun as a military secret, one that

has revealed a method to prolong healthy life. This is how the ground breaking story unfolds.

NATURE’S GENE SWITCHES


It all began in Russia back in the 1980s with a Colonel, the Kremlin and a military secret! A secret that revealed the incredible: tissue, gland and organ specifi c properties of peptide bioregulators. At the center of that secret was a Colonel from the Soviet Union military medical corps, his name was Vladimir Khavinson. Today, Professor Vladimir is the President of the European Academy of Gerontology and Geriatrics, but decades before he had been approached by Kremlin offi cials who wanted him to have the massive responsibility of protecting their troops! So he his team tackled a myriad of problems; there were the challenging issues such as radiation for submariners in nuclear submarines and troops that may be blinded by new weapons such as battlefi eld lasers.

Their secret research was used for two decades on many thousands of men and women – and it uncovered a remarkable link between short chain peptides and DNA.

Through a comprehensive list of patents and copyrights, the Russian research group have shown that each of the concentrated peptide bioregulators so far examined, interact with particular strands of DNA - eff ectively and very specifi cally activating repair and regenerative processes.

It’s no surprise that this work has seen Professor Vladimir Khavinson nominated for the Nobel Prize in medicine.

In this article, we want to inspire you and encourage you to take steps that can prolong and protect your health.

THE HISTORY OF PEPTIDE BIOREGULATORS



A peptide is a short chain of amino acids, identifi ed by the fact that it is shorter than a protein and it can be absorbed via the digestive system. Each organ or bodily function has its own unique peptide bioregulator. Peptide bioregulators have been shown to shortcut the protein synthesis process by interacting directly with cell DNA – meaning that organs can build and repair tissues easier and quicker when peptide bioregulators are active.

A peptide is a short chain of amino acids, identifi ed by the fact that it is shorter than a protein and it can be absorbed via the digestive system. Each organ or bodily function has its own unique peptide bioregulator. Peptide bioregulators have been shown to shortcut the protein synthesis process by interacting directly with cell DNA – meaning that organs can build and repair tissues easier and quicker when peptide bioregulators are active.

From our deep knowledge and years of success stories, we are able to give you the ability to choose to improve your health and potentially prolong your life. The role of peptide bioregulators and their ability to create a protective biological reserve for health and aging can be simplifi ed and explained.

This is a remarkable story since what we are describing here are individualised gene switches and since they have been tested for many years on thousands of individuals, without a report of any serious side eff ects or contraindications to date, they could be set to ‘out do’ stem cells. Why? Because this peptidetherapy is relatively cheap, highly specifi c,

WHAT IS A PEPTIDE BIOREGULATOR?

can be taken orally and doesn’t require any suppression of the immune system to operate fully.

Professor Khavinson and his award winning team at the St Petersburg Institute of Biogerontology have discovered that each organ/gland has a biological reserve and despite the origin of the tissue they have studied, incredibly each one is always set at 42%.

Even dosing doesn’t need to be daily, these peptide bioregulators have been shown to act even after a simple course of 2 capsules daily for 10-days. Healthy individuals only being encouraged to repeat the course 6-months later, although of course depending on the need this course can be repeated every 3-months, 2-months or 1-month if necessary. But compared to a hormone replacement therapy this is interesting, since hormones would require almost daily application. But these peptide bioregulators aren’t hormones, they are acting on the gland concerned to ‘encourage’ it to become active and eff ectively ‘younger’ by triggering/activating the DNA responsible.

Here at IAS we are excited about this emerging technology and have been following it since 2010. There’s still more to learn including the synergistic interaction of the peptide bioregulators themselves and if individuals are using hormones concurrently, then there may well be a need to monitor their blood levels more closely with a view to lowering those doses and applications etc. We will be reporting much more, through articles, interviews and videos etc, so please stay tuned.

As explained, each peptide bioregulator is designed to aff ect a specifi c organ, system or condition in the body and

uses a highly specifi c short chain peptide to act as a ‘short cut’ to initiate protein synthesis. These are some of the peptide bioregulators listed on our site:

Bonomarlot® is the bone marrow peptide bioregulator Bobothyrk® is the parathyroid peptide bioregulator Cerluten® is the brain peptide bioregulator Chelohart® is the heart peptide bioregulator Chitomur® is the bladder peptide bioregulator Endoluten® is the pineal peptide bioregulator Glandokort® is the adrenal peptide bioregulator Gotratix® is the muscle peptide bioregulator Libidon® is the prostate gland peptide bioregulator Pielotax® is the kidney peptide bioregulator Sigumir® is the cartilage peptide bioregulator Suprefort® is the pancreas peptide bioregulator Stamakort® is the stomach mucus peptide bioregulator Svetinorm® is the liver peptide bioregulator Taxorest® is the lung peptide bioregulator Testoluten® is the testes peptide bioregulator Thyreogen® is the thyroid peptide bioregulator Ventfort® is the blood vessel peptide bioregulator Visoluten® is the retina peptide bioregulator Vladonix® is the thymus peptide bioregulator Zhenoluten® is the ovary peptide bioregulator


41AGINGMATTERS

Correction of disorders and maintenance of the functions of the digestive system: Svetinorm, Suprefort, Stamakort.

Correction of disorders and maintenance of the functions of the vascular system: Ventfort, Svetinorm, Vladonix.

Correction of disorders and maintenance of the functions of the central nervous system: Cerluten, Ventfort, Svetinorm.

Correction of disorders and maintenance of the functions of the immune system: Vladonix, Endoluten, Ventfort.

Correction of disorders and maintenance of the functions of the locomotor apparatus: Sigumir, Ventfort, Vladonix.

Correction of disorders and maintenance of the functions of carbohydrate metabolism: Suprefort, Endoluten, Ventfort.

Correction of disorders and maintenance of the functions of lipoprotein metabolism: Svetinorm, Suprefort, Ventfort.

Correction of disorders and maintenance of the functions of the functions of the thyroid gland: Thyreogen, Ventfort.

Correction of disorders and maintenance of the functions of visual acuity: Visoluten, Cerluten, Ventfort.

Correction of disorders and maintenance of the functions of the kidney functions: Pielotax, Ventfort.

Correction of organism status after radio and chemotherapy, long-term ionizing irradiation, psychoemotional stress and similar adverse factors: Vladonix, Svetinorm, Endoluten.

Correct of cardiovascular disorders: Chelokhart, Ventfort, Svetinorm.

Of all the peptide bioregulators, Professor Khavinson considers ‘Endoluten’ as the most eff ective product available for preventing premature aging. Endoluten is a peptide bioregulator specifi cally harnessed to boost and protect the function of the pineal gland.

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PROFESSOR KHAVINSON’S PEPTIDE BIOREGULATOR RECOMMENDED COMBINATIONS



By secreting melatonin, the pineal gland plays a vital role in ensuring the body reacts appropriately to natural rhythms like wakefulness and drowsiness. Regular disruptions in sleep patterns can lead to disorientation, fatigue, a lowered immune system and depression. Many age-related illnesses feature hormonal-imbalance as a key factor. The pineal gland is also part of the endocrine system, which manages the balance of hormones in the body. If this delicate balance is disrupted then any number of attendant problems and conditions can arise.

When asked in an interview about his thoughts on peptide bioregulators, Professor Vladimir Khavinson commented…

“I think it may improve everyday life of seniors, who constitute the most vulnerable group of population. Europeans and America are getting older and living longer than ever before, nearly 10 years more than in 1960. Increased longevity is a great achievement and a great challenge. It is our task to turn challenges into opportunities and to make the most of the chances off ered by the scientifi c community. Peptides will bring medicine and health systems to a new level with an accent to preventive medicine which will help to enhance human vital resource and add life to years.”

You can read the whole interview with Professor Khavinson here:www.antiaging-systems.com/articles/326-the-role-of-pep-tide-bioregulators-interview-with-vladimir-khavinson

THE IMPORTANCE OF THE PINEAL GLAND

The Endoluten peptide bioregulator works with the pineal gland to help regulate melatonin and the neuro-endocrine system. It helps normalize sleep patterns and energy levels.This particular peptide supports libido and fi ghts against cancers of the reproductive glands. It serves the same role as peptide bioregulators developed naturally in the body.

WHAT ARE THE BENEFITS OF THE ENDOLUTEN® PEPTIDE BIOREGULATOR?



20 x 200mg capsulesBuy any 3 and save $9.99 per box

Peptide Bioregulators, gene switches that could replace stem cells!





SPOTLIGHT

THE PEPTIDE BIROREGULATORS FOR SKIN

Four peptide bioregulators have now been combined into topical skin preparations so that their unique gene-switching performance can be bought to the fi eld of aesthetic medicine.

What does each peptide provide for?

The beauty product line Youth Gems contains the following four peptides and a ginseng extract called Neovitin. The latest developed program of complex skin care designed for the face, neck, hands and the body.

The line includes four unique active ingredients of short-chain peptides that have a directed tissue-specifi c action to improve all basic skin structures:

• Thymus peptide: Stimulates tissue regeneration and synthesis of tissue-specifi c proteins. Cells proliferative and metabolic activity is enhanced accelerating the renewal of cell tissues. Has an anti-infl ammatory action, improving healing time of wounds, as well as antioxidant, immune stimulating and anti-stress actions.

• Pineal peptide: Regulates metabolic processes and increases protein synthesis in skin cells. It possesses potent antioxidant activity, normalizes the lipid peroxidation processes in skin

cells that promotes the elimination of negative infl uences on the skin from external factors.

• Cartilaginous peptide: Stimulates regeneration of fi broblasts and keratinocytes and interferes with the destructive changes in collagen skin structure. It strengthens collagen structure of elastic skin fi bres and increases elasticity.

• Blood vessel peptide: Regulates metabolic processes in the vascular wall, normalizes vascular tone and restores disturbed skin microcirculation. It strengthens and regulates the permeability of the vascular walls of skin vessels and improves skin turgor.

Youth Gems contain benefi cial natural agents. The range includes: Neovitin (a complex from ginseng), olive oil, raisin-seed oil, Argon oil, Soya oil, Jojoba oil, Bisabolol ( from chamomile), Peony extract, sodium hyaluronate (derivative of hyaluronic acid), green tea extract, cocoa oil, carrageenan (from seaweed), winter bloom, almond extract and vitamin E.

What results have been seen?

Clinical trials and examinations have been conducted at the St. Petersburg Biogerontology Institute. They concluded that these short chain peptides have many benefi cial activities.

Improved metabolism in vascular wall cells, growth of new skin cells, enhanced antioxidant activity, increased blood fl ow circulation and greater moisturization. The skin’s appearance becomes smoother, fewer wrinkles and more elasticity, which helps to lift the face contours producing a more radiant, youthful appearance. These benefi cial eff ects were noted in 100% of women who took part in the voluntary clinical trial.

What’s available?

Body milk: A very light cream that can be applied to most areas of the body.

Day cream: A core product designed to be applied to the face and hands.

Serum: To be used sparingly against the most noticeable skin aging eff ects on the face and neck.

Tonic: Used to help any area become more fi rm and taught and may be splashed on as required.

Face pack: An anti-aging facial mask with peptides and ginseng extract.

Night cream: This unique formula provides resilience against skin aging.

All of the Youth Gems products should be applied onto clean, dry skin - avoiding the eyes. Makeup can be applied after absorption - if required.

YOUTH GEMS

45AGINGMATTERS

A REAL ‘ORAL’ ALTERNATIVE TO GH INJECTIONS

Since Dr. Rudman’s research work in the 1980s and the release of Dr. Klatz’s book ‘grow young with HGH’ in the 1990s, there has been great interest in the use of growth hormone (GH) in antiaging medicine. Dr. Rudman concluded, having injected elderly patients with GH, many had reversals of biological age markers by as much as 20-years. Improved skin, hair, muscle mass, decreased fat levels and enhanced levels of stamina, strength and well-being. It’s not surprising given the multi-faceted role of growth hormone and as its name suggests it is involved in the growth and repair of tissues.

GH injections

The issue with injecting GH, other than expense, is it has to be injected to be eff ective because as a 191 chain amino acid it can’t be absorbed another way. GH injections can be classifi ed as a controlled substance, due to its anabolic actions. They could require special import and export licenses.

Dr. Richard Walker researched and highlighted that bolus injections of GH are not bio-identical and they induce spikes of GH into the blood so could damage the pituitary gland, leading to a down-regulation of its production of GH, or stop GH production altogether.

Dr. Walker’s research shows using GHRPs (growth hormone releasing peptides) have a safer profi le with the same benefi ts.

Read this article in the Aging Matters™ magazine, No:3, 2014 to understand more.

GHRPs (growth hormone releasing peptides)

GHRPs, (GHRP2, GHRP6 and sermorelin) have these benefi ts:

They can be sublingually, intra-nasally and even orally, avoiding the need for needles

Their feedback loop means they cannot cause the pituitary to down-regulate

GHRPs are not controlled substances

Rather than inducing a spike of GH in the blood, GHRPs augment (improve) each release of GH naturally into the blood

Sermorelin is the precursor to GH, being the fi rst 29 amino acids and is applied via the sublingual route. Its function may be to release existing stores of GH from the pituitary- rather than encourage more production as a pure agonist would. Dr. Walker highlighted that combining sermorelin with GHRP2 or GHRP6 has a highly synergistic eff ect, in some cases

eliciting up to a 5x greater quantity of GH into blood, an action that can be equivocated to using injectable GH itself.

Note: You can hear Dr. Walker discuss this with us on the IAS video page:

www.youtube.com/watch?v=S5OlEhbM7lQ

The diff erences:

GHRP6 may induce more hunger feelings than GHRP2 and could improve levels of IGF-1 more. Recommended for those who want to put on muscle mass

GHRP2 may create fewer hunger feelings. Preferable to those who want to stimulate GH for fat loss. Also as the GHRP6 (Release-Pro™) is a nasal spray, those who don’t like that may prefer GHRP2-Pro™ which can be swallowed

GHRPs have created a genuine effi cacious alternative; simple and easier to use. They have a better/ safer profi le than injectable GH.

GHRPs

SPOTLIGHT


FOR PASSION AND SEX

Oxytocin is a hormone produced by the hypothalamus, excreted via the pituitary gland. Its orthodox medicine role is to help women give birth, since the large dose that’s injected helps relaxes the uterus and alleviates the passage of the child. Dr. Thierry Hertoghe’s book, ‘Passion, sex and longevity, the oxytocin adventure’ highlights that it has many other roles too.

The love hormone

Oxytocin has been dubbed ‘the love hormone’. It can induce feelings of bonding and care. Its measurements have been taken between lovers, friends, relatives, parents and their children etc. It has been noted that oxytocin levels are higher when they are in their presence. Mothers naturally bond with their children, but even men, (especially those who experience the live birth), express their emotions as wanting to care and protect their off spring. These eff ects may be attributable to the release of oxytocin hence triggering the bond. However, psychopaths are notoriously low in their oxytocin levels, which may be a cause of their uncaring feelings towards other humans.

The pain and orgasm connection - Fibromyalgia can be a very debilitating disorder with a lot of pain, sometimes constant for those who suff er with it. In women, it was noted that when they were experiencing an orgasm they felt no pain at all. Women undergo a burst of oxytocin during orgasm. Trials were undertaken to see if oxytocin supplementation could alleviate the pain of fi bromyalgia, there was some success, but the side-eff ect noted was that those women now enjoyed multiple orgasms!

The eff ects of Oxytocin

Dr. Hertoghe explained that some will not feel the eff ects of Oxytocin. For two reasons, (if we consider that the dose is correct for that individual). Firstly, some people are ‘low’ in their own principal sex hormone, so if a man is low testosterone, or if a woman is low estrogen, it is possible that oxytocin will not elicit its full potential in those persons. The other issue could be low vasopressin, vasopressin is a counterpart to oxytocin, produced and released via the same glands. In cases of vasopressin defi ciency, the patient may enhance the oxytocin experience by adding one or two sprays (10 IU each) of vasopressin via the Vaso-Pro nasal spray.

Doses are very dependent upon its use. For social or sexual enhancement, 5 IU to 10 IU is a ‘typical’ dose. Dr. Hertoghe reduced the doses that he recommends in his book, (transmitted via personal conversation to me). Currently, IAS is providing Oxy-Sub in 20 IU trouches (a soft sublingual tablet). These can be cut into half or quarter for a dose of 5 or 10 IU and should be placed under the tongue and allowed to melt. The other option is Oxy-Pro which is applied intranasally delivering 10 IU per spray.

OXYTOCIN

SPOTLIGHT

47AGINGMATTERS

SPOTLIGHT

CUFFBIOCLIP®

MONITORING YOUR VASCULAR CONDITION

The BioClip® Cuff is a simple way of assessing both your blood pressure condition and your arterial fl exibility. You can use it in the comfort of your own home. You simply attach the device to your arm just like an ordinary blood pressure cuff .

What does the BioClip® Cuff measure?

It provides a series of metabolic indicators that you can use to improve your lifestyle and help prevent the causes of cardiovascular disease

These include:

• Diastolic blood pressure

• Systolic blood pressure

• The heart rate

• Vascular condition – which links to arterial fl exibility

We know the risks of being overweight, having high cholesterol or suff ering from high blood pressure. We know how to reduce those risks – exercising, not smoking, reducing alcohol intake and

eating a balanced diet. Few of us know about the dangers of arterial infl exibility, or how to measure it. BioClip® Cuff is unique, the fi rst at-home device able of delivering information to you within minutes. It evaluates your arterial fl exibility, a most important factor when it comes to assessing the likelihood of a heart attack or stroke. Arteries are responsible for blood fl ow around your body via your cardiovascular system. The poorer your vascular condition, the greater your chances of serious health issues. Our arteries stiff en with age, bringing greater risk of a heart attack, heart failure or stroke. You may not recognise the symptoms, arterial stiff ness can occur without warning.

Summary:

The BioClip® Cuff provides a cardiovascular condition scale, shown by LED bars - that are either within the green zone (good), yellow zone (fair) or red zone (poor). Like blood pressure, vascular condition should be monitored over time and not just taken as one reading. The BioClip® Cuff makes this simple by averaging your tests over time and therefore provides a more accurate result. It provides reassurance and a vital early warning system that helps you be aware of changes and therefore keep your vascular condition in check.

The BioClip® Cuff is easy to use. It doesn’t puncture your skin and is used on its own, without any additional attachments. The procedure is straightforward and you don’t need to link to a computer, the results are shown on the BioClip® Cuff screen.

If you want to see it in action there is a video available on the IAS website. With this information, it’s easy to keep a check on your cardiovascular health and the risks associated with arterial stiff ness, such as heart attacks and strokes. It is possible to make changes to your lifestyle and supplement program to improve results and keep you biologically younger! Above all, the BioClip® Cuff provides reassurance and a vital early warning system that helps you to be aware of changes and therefore keep your vascular condition in check.


Addison’s disease Aldosterone, peptide bioregulator (adrenal)

ADHD (ADD, attention defi cit disorder, see mental stimulants)

Adrenal fatigue Aldosterone, hydrocortisone, peptidebioregulator (adrenal)

AGE (advanced glycated end-product inhibitors) ACF228™, aminoguanidine, Can-C™ Plus, carnosine, metformin

Age Related Macular Degeneration (see eyesight)

Age Related Mental Decline (see cognitive)

Aids (see HIV)

Alcoholism (also see compulsive disorders) 5HTP, L-tryptophan, memantine

Allergies Pregnenolone, thymus

ALS (amyotrophic lateral sclerosis, Lou Gehrig’s disease) Naltrexone, TRH

Alzheimer’s disease (see senile dementia)

Anabolic (see growth hormone & testosterone)

Anginas (see heart, arterial & blood)

Animal use Can-C™ eye-drops, deprenyl, L-tryptophan, peptide bioregulators (all)

CONDITION CROSS-REFERENCE LIST

This cross-reference list highlights individual products that have been used for these disorders.Note: It does not mean that all these products are synergistic together.

Antiaging (as impacting on a particular theory of aging)

Calorie Restriction Carnosine, metformin, resveratrol Free radical ACF228™ Glycation Aminoguanidine Hayfl ick Carnosine, Peptide Bioregulator (pineal), TA65®

Membrane Centrophenoxine Mitochondrial HyPro2™, PQQ Neuroendocrine Metformin, TRH Rotational Melatonin Telomeres Peptide biomarker (pineal), TA65®

Anti-biotics Ciprofl axin, doxycycline, roxithromycin,tetracycline

Anti-depressants Lithium, milnacipran (Ixel®),reboxetine (Edronax®), Stablon®, Valdoxan®,venlafaxine (Efexor®)

Anti-oxidants (see free radical scavengers)

Anxiety (see stress)

ARMD (see eyesight)

Arterial (See heart, arterial & blood)

Arthritis (rheumatoid & osteo) Andro-Pro™,Gerovital-H3®, Novisyn®, PEO pregnenolone, SAMe, thymus,

Asthma (see Allergies)

CROSS-REFERENCE

49AGINGMATTERS

Autism (also see chelation agents) Oxytocin, piracetam

Back problems (see spine)

Bell’s palsy Vitamin B12

Blood disorders (see heart, arterial & blood)

Blood pressure Magnesium, Neo40®, oxytocin, potassium, propranolol, vinpocetine

Bone problems (also see joints & arthritis) Andro-Pro™, Bone-Pro2™, Esnatri™, peptide bioregulator (Bone), progesterone, SAMe, thyroid

Breathing (see lungs)

Cancer (also see anti-oxidants & radiation) 1st Line™,anastrozole, BEC5® Curaderm, bromocriptine, curcumin, DIM-Pro2™, laetrile, melatonin, metformin, naltrexone, oxaloacetate, progesterone, resveratrol, thymus, TRH

Cardiovascular (see heart & arterial disorders)

Cataplexy (sudden fatigue) Adrafi nil, picamilone

Cataract (see eyesight)

Central Nervous System (CNS) Peptide bioregulator (brain)Peptide bioregulator (Cerluten®)

Chelation agents Carnosine, centrophenoxine, DMSA, EDTA, zeolite

Cholesterol (see blood disorders)

Crohn’s disease Naltrexone

Chronic fatigue syndrome (see mental stimulants & physical energy improvement)

Cognitive (also see memory & senile dementias)

Alertness Adrafi nil, Xan-Pro™ Creativity Aniracetam, piracetam, pramiracetam Focus/ concentration Deprenyl, desmopressin, vasopressin Energy ATP-Boost™, centrophenoxine, Mito-Pro2™, NADH, picamilone General support Gerovital-H3®, vinpocetine Intelligence HyPro2™ Work load HyPro2™, thyroid

Compulsive disorder treatment (also see alcoholism) 5HTP, GABOB, L-tryptophan, picamilone

Cortisol alteration (also see stress) Aldosterone, DHEA, GABOB, Gerovital-H3®, hydrocortisone, peptide bioregulator (adrenal), phenytoin

Cross linking (see AGE)

Deep vein thrombosis (see frequent fl iers)

Dental (see teeth & gums)

Depression (also see well-being & anti-depressants) 5HTP, aniracetam, ATP-Boost™, curcumin, deprenyl, Gerovital-H3®, lithium, L-tryptophan, milnacipran, picamilone, piracetam, pramiracetam, pregnenolone, SAMe, thymus, thyroid

DHT alternation (dihydrotestosterone) Dutasteride, fi nasteride, peptide bioregulator (prostate), progesterone

Diabetes Acarbose, aminoguanidine, ATP-Boost™, benfotiamine, L-carnosine, metformin, Mito-Pro2™, PEO, peptide bioregulator (pancreas), pyridoxamine, thyroid, TRH

Diabetes insipidus (see urination)

Dieting (see weight loss)

Digestive issues peptide bioregulator (Stomach), Symprove®

DNA support (also see telomeres) Carnosine, CoQ10, PEO, peptide bioregulator (pineal), PQQ, resveratrol, TA65®

Down’s syndrome Melatonin, piracetam

Energy improvement (see physical energy & mental stimulants)

Enzymes Boluoke®

Epilepsy GABOB, phenytoin

Erectile dysfunction (also see sex-libido & premature ejaculation) Andro-Pro™, cabergoline, deprenyl, Neo40®, oxytocin, sildenafi l, Vielight®, VigorPro2™

Eyesight

ARMD MZS™ Cataracts Can-C™, Can-C™ Plus Contact lenses Can-C™ Dry eyes Can-C™ General support Aminoguanidine, peptide bioregulator (retina), vinpocetine Glaucoma Can-C™ Retinal MZS™, picamilone Retinal pigmentosa Picamilone, peptide bioregulator (retina)

Excitotoxins (reduction) Carnosine, deprenyl, idebenone, lithium, memantine

Fertility Melatonin, metformin, peptide bioregulator (ovaries), TRH

CROSS-REFERENCE


Fibromyalgia (also see physical energy & mental stimulants & pain relief) 1st Line™, milnacipran, naltrexone, oxytocin

Free radical scavengers ACF228™, ATP-Boost™, BHT, glutathione, idebenone, melatonin, Mito-Pro2™

Gastrointestinal (see digestive)

Glaucoma (see eyesight)

Glucose control (see diabetes)

Glycation prevention (see AGE)

Gout Colchicine

Growth hormone (improvement) Bromocriptine, deprenyl, GABOB, GHRP2, GHRP6, HyPro2™, IGF-1, Neo40®, sermorelin, thymus, thyroid

Hashimoto’s Iodine, peptide bioregulator (Thyroid), thyroid

Hair improvement Dercos®, dutasteride, fi nasteride, Gerovital-H3®, MinMaxPro™, PEO

Headaches (see migraines)

Health diagnostics (see at home test kits)

Hearing disorders Aldosterone, picamilone, vinpocetine

Heart, arterial & blood (includes blood markers)

Arteries (hard) Aminoguanidine, BioClip® Cuff , carnosine, resveratrol Blood pressure (high) Magnesium, Neo40®, potassium, propranolol, vinpocetine Calcium Peptide bioregulator (parathyroid) Cholesterol (high) CoQ10, Gerovital-H3®, MitoQ®, TRH, Xan-Pro™ Dilation (nitric-oxide) Deprenyl, Neo40®, Vielight®

Fibrinogen Curcumin, TRH General support CoQ10, PEO, peptide bioregulators (heart and blood vessel), PQQ, vinpocetine Glucose (high) Acarbose, metformin, TRH Glycated end-products ACF228®, aminoguanidine, metformin Heart pulse (irregular) ATP-Boost™, thyroid Heavy metals (chelate) DMSA, EDTA, zeolite Homocysteine TRH Lipofuscin Centrophenoxine Plaques (clots) Boluoke®

Triglycerides Curcumin, PEO, TRH

Hepatitis (see liver and infections)

Herpes (also see anti-biotics) 1st Line™, ACF228™, BHT, silver

HIV (also see immune system improvement) 1st Line™, melatonin, naltrexone, thymus

HCG (see HCG-Pro™)

HGH (see growth hormone)

Homocysteine (see heart, arterial and blood)

HRT (hormone replacement therapy for women) DHEA, Esnatri™, melatonin, progesterone

Human growth hormone (see growth hormone)

Hypertension (see blood pressure)

Hypothyroidism Iodine, peptide bioregulator (thyroid), thyroid

IBS (irritable bowel syndrome) Symprove®

Immune system improvement (also see infections) 1st Line™, ATP-Boost™, beta-glucans, carnosine, melatonin, peptide bioregulator (thymus), peptide bioregulator (thyroid), resveratrol, thymus, thyroid

Infections (also see immune system improvement, anti-biotics & infl uenzas) 1st Line™, beta-glucans, fl uconazole, silver

Infl ammation (reduction) Boluoke®, curcumin, PEO, pregnenolone, thymus

Infl uenzas (also see anti-biotics, infections & immune system improvement) 1st Line™, beta-glucans, vitamin D3

Injectable products Gerovital®, IGF-1, vitamin B12

Insulin & glucose control (see diabetes)

Intestinal fl ora (see probiotics)

Intra-ear products Aldo-Spray™

Intra-nasal products Desmopressin, GHRP6, HCGPro™, vasopressin, Vielight®

Joints (also see bones & arthritis) Boluoke®, Novisyn®, PEO, peptide bioregulator (cartilage), pregnenolone, SAMe, thymus

Kidney disorders (also see infections) Aminoguanidine, peptide bioregulator (kidney) SAMe, TRH

Learning (also see memory & mental stimulants) Aniracetam, desmopressin, HyPro2™, piracetam, pramiracetam, vasopressin

CROSS-REFERENCE

51AGINGMATTERS

Libido (see sex)

Lipids (see blood disorders)

Liver disorders (also see infections) CoQ10, idebenone, peptide bioregulator (liver), pregnenolone, SAMe, silver

Longevity enhancement (signifi cant lifespan increases seen in animal studies) Centrophenoxine, deprenyl, melatonin, peptide bioregulator (pineal) vasopressin

Lou Gehrig’s disease (see ALS)

Lungs ACF228™ Breathe-Easy, centrophenoxine, glutathione, peptide bioregulator (lungs)

Lupus Milnacipran, naltrexone

Lyme’s 1st Line™, beta-glucans, silver

Macular degeneration (see eyesight)

Malaria (see anti-biotics)

Menopause (see HRT)

Mental stimulants (also see physical stimulants) Adrafi nil, aniracetam, centrophenoxine, deprenyl, desmopressin, picamilone, piracetam, pramiracetam, vasopressin, Xan-Pro™

Memory (also see cognitive & senile dementia)

General support PEO, picamilone, vinpocetine Imprinting (for later recall) Desmopressin, vasopressin Medium-long term HyPro2™ Short term Aniracetam, piracetam, pramiracetam Speed of recall Centrophenoxine

Methylation (conversion of one chemical into another inside the body) ATP-Boost™, Boluoke®, Mito-Pro2™, SAMe, Xan-Pro™

Migraines (also see pain relief) Nicergoline, memantine, picamilone, vitamin B12

Mitochondrial support ATP-Boost™, CoQ10, deprenyl, glutathione, HyPro2™, idebenone, MitoQ™, NADH, oxaloacetate, PQQ, pregnenolone, SAMe

Mtor inhibitors Curcumin, oxaloacetate, resveratrol

Multiple Sclerosis (also see mitochondrial support) Melatonin, naltrexone, TRH

Muscles (see sarcopenia)

NAD+ activators NAD+Pro™

Nail condition Gerovital-H3®, PEO

Narcolepsy (sleeping in the daytime) Adrafi nil, melatonin, picamilone

Nitric Oxide release Neo40®, Nitric Oxide saliva test strips, Vielight®

Oral health care (see teeth & gums)

Osteoporosis (see bone problems)

Pain relief (general) ATP-Boost™, Gerovital-H3®, memantine, milnacipran, oxytocin

Parasites (see infections)

Parkinson’s disease (see senile dementia)

Pets (see animal use)

Photoaging (see skin problems)

Ph balance (rebalancing) Symprove®

Physical energy improvement (also see mental stimulants) ATP-Boost™, carnosine, CoQ10, idebenone, MitoQ™, NADH, oxaloacetate, PQQ, pregnenolone, SAMe

PMS (pre-menstrual syndrome) PEO, peptide bioregulator (ovaries), vinpocetine

Premature ejaculation/ ejaculate (also see erectile dysfunction & sex-libido) Oxytocin

Probiotics Symprove®

Prostate (also see cancer) DIM-Pro2™, dutasteride, fi nasteride, melatonin, peptide bioregulators (bladder and prostate), Prostate-Pro2™

Prolactin alteration Bromocriptine, cabergoline, GABOB

PSA (prostate specifi c antigen- see prostate)

Urination (frequent) Peptide bioregulator (bladder), vasopressin

RNA (see DNA support)

Sarcopenia (muscle atrophy/ wastage) GHRP2, GHRP6, peptide bioregulator (muscle), sermorelin

CROSS-REFERENCE


Senile dementia (also see cognitive & memory)

Alzheimer’s Centrophenoxine, curcumin, galantamine, HyPro2™, memantine, nicergoline General support aniracetam, PEO, piracetam, pramiracetam, vinpocetine Parkinson’s Bromocriptine, cabergoline, deprenyl, NADH, memantine, rasagiline

Senility Gerovital-H3®

Sex (libido, also see erectile dysfunction & premature ejaculation) Andro-Pro™, deprenyl, MSH2, oxytocin, VigorPro2™

Skin problems (also see herpes and tanning)

Acne Beta-glucans Age (liver) spots Centrophenoxine, Youth Gems® face mask Anti-glycation Aminoguanidine, carnosine, Youth Gems® serum Anti-oxidant Youth Gems® day cream and night cream Cancer (non-melanoma) BEC5® Curaderm Cellulite Youth Gems® body milk Collagen Novisyn®

Environmental Youth Gems® serum and face mask General support Gerovital-H3®, melatonin, PEO, thyroid Infections Silver, thymus Moisturizer Youth Gems® day cream and night cream Psoriasis Beta-glucans Scars RetinPro™ Sun spots (keratosis) BEC5® Curaderm Wounds Silver Wrinkles RetinPro™

Sleep disorders

For less sleep Adrafi nil, ATP-Boost™ For more sleep 5HTP, gabapentin, L-tryptophan, melatonin

Smoking cessation 5HTP

Spine issues (also see growth hormone) Novisyn®, peptide bioregulator (cartilage)

Sports (see growth hormone, estrogen alteration, physical energy & testosterone)

Stem Cells Stem Cell Worx®

Stress (also see cortisol) 5HTP, GABA, Gerovital-H3®, L-tryptophan, melatonin, oxytocin, picamilone, phenytoin, pregnenolone, propranolol

Stroke Aniracetam, Boluoke®, HyPro2™, idebenone, PEO, picamilone, piracetam, PQQ, pramiracetam, pregnenolone, vinpocetine

Stomach (see digestive)

Sublingual products Oxytocin, sermorelin, TRH

Sunburn (see skin problems)

Syndrome X (metabolic syndrome) Aminoguanidine, ATP-Boost™, melatonin, metformin, Mito-Pro2™, PEO

Tanning (darkening the coloration of skin) MSH2

Teeth & gum disorders Doxycycline, Min-Mouth™ mouthwash, NeyDent® toothpaste, silver, zeolite

Telomeres (also see DNA support) Carnosine, PEO, peptide bioregulator (pineal), TA65®

Testosterone & testes (also see fertility and prostate) Anastrozole, Andro-Pro™, DIM-Pro2™, melatonin, oxytocin, peptide bioregulator (testes), TRH, VigorPro2™, zinc

Topical products BEC5®, beta-glucans, Can-C™ eye-drops, Esnatri™, progesterone, RetinPro™, silver, Youth Gems®

Triglycerides (see blood disorders)

Veterinarian (see animal use)

Weight gain (muscle mass) Andro-Pro™, GABOB, GHRP6, sermorelin

Weight loss (appetite suppressants and fat burners) 5HTP, acarbose, aminoguanidine, ATP-Boost™, DHEA, DIM-Pro2™, galantamine, GHRP2, HCG, L-tryptophan, metformin, Mito-Pro2™, MSH2, thyroid, TRH, Xan-Pro™

Well-being (also see depression) 5HTP, aniracetam, ATP-Boost™, deprenyl, GABA, Gerovital-H3®, L-tryptophan, melatonin, Mito-Pro2™, PEO, picamilone, piracetam, pramiracetam, SAMe, thymus, thyroid, zeolite

CROSS-REFERENCE

53AGINGMATTERS

A-Z INGREDIENT LISTThe following list is intended to highlight the key ingredients in some products and cross reference them to the most relevant product brand names.Note: Those products with the same name as the ingredients are not shown here as they are within the A-Z product list.

If you want this- Look for:

A-Z INGREDIENT LIST

5-hydroxy-tryptophan

Acetyl-L-Carnitine (ALC)

Adenosine triphosphate (ATP)

Aglomelatine

Allicin (garlic)

Alpha lipoic acid (R-lipoic acid)

Aminexil

Amino acids (includes di-peptides

Aminohydroxybutyric acid (GABOB)

Aminosyn

Anti-biotics

Anti-depressants

Anti-oxidants

Arginine

Arimidex®

Astragalus extracts

Azelaic acid

Azilect®

Benzoic acid

Beta blocker

5HTP

ATP-Boost™, Vigor-Pro2™

ATP-Boost™

Valdoxan®

EDTA-Pro™

ATP-Boost™, Mito-Pro2™

Dercos®

5HTP, ACF228™, ATP-Boost™, carnosine, L-tryptophan, Mito-Pro2™

Gamibetal®

Hair-Pro™

Ciproxin, doxycycline, penicillin, roxithromycin, tetracycline

Lithium, milnacipran, moclobemide, reboxetine, Stablon®, Valdoxan®, venlafaxine

See free radical scavengers,

Mito-Pro2™

Anastrozole

TA65®

Minox-Pro™

Rasagiline

Gerovital®

Propranolol

Beta alistine

Beta glucan

bFGF

BHT (butylhydroxytoluene)

Blueberry extracts

Borate

Boron

Buxamin (GABOB)

Caff eine

Calcium

Carboxymethylcellulose

Catalase

Chelation agents

Choline

Chromium polynicotinate

Citrulline

Co-dergocrine mesilate

Coenzyme Q10

Colloidal Silver

Colostrum

Cortisol (cortisone)

Cranberry extracts

Creatine

Cresote bush

Carnosine, ACF228™, Can-C™, Can-C Plus™

BG-Cream™, BG-Pro™

Hair-Pro™

ACF228™, BHT-Pro™

Andro-Pro™

Andro-Pro™, Can-C™

Andro-Pro™

Gamibetal®

Minox-Pro™

Bone-Pro2™

Can-C™

ACF228™

Carnosine, centrophenoxine, DMSA, EDTA-Pro™, zeolite

Centrophenoxine

ACF228™

Neo40®

Hydergine®

CoQ10, Mito-Pro2™

Silver

Stem Cell Worx®

Fludrocortisone, hydrocortisone

Andro-Pro™

Mito-Pro2™

ACF228™



A-Z INGREDIENT LIST

Cycloastragenol

Cyclodextrin

Dehydroepiandrosterone

Detox

DHA (docosahexaenoic acid)

Diapid®

Di-IndolylMethane (DIM)

Dilantin®

DMAE (dimethylaminoethanol)

DMSA (dimercaptosuccinic acid)

D-pantethine

Dr. Dean’s recommendations

Dr. Pierpaoli’s recommendations

Dr. Wright’s recommendations

Ebixa®

EDTA (ethylene diamine tetraacetic acid)

Eldepryl®

Electrolytes

Enzymes

EPA (eicosapentaenoic acid)

Ergoloid mesylate

Estrogens (estradiol, estriol, estrone)

Finasteride

Florinef®

Folic acid (folate)

Free radical scavengers

Fructoborate

Fucoidan

GABA (gamma-aminohydroxybutyric acid)

GABOB

GHRP6

Ginseng

Glucophage®

Glutathione

Glycerine (glycerin)

Glycosides

Hawthorne Berry (crataegus)

HGH (human growth hormone/somatropin)

Hormones (includes hormonal support supplements)

HRT (hormone replacement therapy for women)

TA65®

CoQ10-SR™, Curcumin-SR™, resveratrol

DHEA

DIM-Pro2™, EDTA-Pro™, zeolite

PEO-Pro™

Vasopressin

ACF228™, DIM-Pro2™

Phenytoin

Centrophenoxine

ACF228™, DMSA-Pro™

Can-C Plus™

Acarbose, centrophenoxine, CurcuminSR™, Hydergine®, metformin, piracetam, Xan-Pro™

Melatonin, TRH

DHEA, Esnatri™, progesterone

Memantine

EDTA-Pro™

Deprenyl

Volt-Pro™

Boluoke®

PEO-Pro™

Hydergine®, nicergoline

Esnatri™

Hair-Pro™

Fludrocortisone

ACF228™, DIM-Pro2™

ACF228™, ATP-Boost™, BHT, glutathione, idebenone, melatonin, Mito-Pro2™, pyritinol

Andro-Pro™

Stem Cell Worx®

picamilone

Gamibetal®

Release-Pro™

Youth Gems®

Metformin

ACF228™, ACG

Can-C™

BEC5 Curaderm®

Neo40®

GABOB, GHRP2, GHRP6, sermorelin

Bio-identical: Aldosterone, DHEA, Esnatri™, melatonin, MSH, oxytocin, pregnenolone, progesterone, TRH

Natural (animal): Armour® thyroid, ERFA® thyroid, Nature® thyroid, thymus, vasopressin

Synthetic: Desmopressin, Eutirox® thyroid, fl udrocortisone, hydrocortisone, T3-Pro™

Supporting agents: DIM-Pro2™, GHRP2, GHRP6, peptide bioregulators, SAMe, sermorelin

DHEA, Esnatri™, melatonin, progesterone

55AGINGMATTERS

A-Z INGREDIENT LIST

Hyaluronic acid (hyaluronan)

Hydergine (ergoloid mesylates)

IGF-1 (insulin like growth factor one)

Indol-3-Carbinol (I3C)

Iodide/ Iodine

Ixel®

Ketoconazole

L-arginine

L-carnitine

L-carnosine

L-citrulline

L-histidine

Lipoic acid (includes R-lipoic acid)

L-methione

Lucidril®

Lumbrokinase

Magnesium

Malic Acid

Manganese

Meclofenoxane

Melanocyte stimulating hormone

Mild Silver Protein

Milk protein

Minerals (general)

Minoxidil

N-acetylcarnosine

N-acetylcysteine

Namenda®

Neurontin®

Nettle root extract

Niacin (nicotinate, niacinamide, vitamin B3)

Nicotinamide adeninedinucleotide

Nootropil®/ Nootropyl®

Nordihydroguaiaretic acid (NDGA)

Omega 3 (DHA)

Omega 6 (linoleic acid,GLA)

Omega 9 (oleic acid)

Oxythiocynate (OCSN)

Parent Essential Oils (PEO)

PABA (para-aminobenzoicacid)

Panthenol (pantothenicacid)

PCPA (paarachloro- phenoxyacetic acid)

Pepermint Oil

Peptides

Pimagedine

Pomegranate extracts

Potassium

Prasterone

Propionyl-L-carnitine

Probiotics

Procaine (Novocain®)

Pygeum africanum

Hair-Pro™, Novisyn®

Hy-Pro™

IGF-1 (LR3)

DIM

ACF228™, Iodine-Pro™

Milnacipran

Nizoral®

Mito-Pro2™

Mito-Pro2™

Carnosine, ACF228™, Can-C™, Can-C Plus™

Neo40®

Can-C Plus™

ATP-Boost™, Mito-Pro2™

ACF228™, Can-C Plus™

Centrophenoxine

Boluoke®

Andro-Pro™, Bone-Pro2™, Magnesium-Pro™, Mito-Pro2™

EDTA-Pro™

Mito-Pro2™

Centrophenoxine

MSH2

Silver

Bone-Pro2™

Min-Mouth™ (mouthwash),Volt-Pro™

MinMax-Pro™

Can-C™

ACF228™, Can-C™ Plus

Memantine

Gabapentin

Prostate-Pro2™

Picamilone, Xan-Pro™

NADH, PQQ

Piracetam

ACF228™

PEO-Pro™

PEO-Pro™

PEO-Pro™

1st Line™

PEO-Pro™

Gerovital®

Mito-Pro2™

Centrophenoxine

Min-Mouth™ mouth rinse

GHRP2, GHRP6, peptidebioregulators, sermorelin,TRH, Youth Gems®

Aminoguanidine

Andro-Pro™

Gerovital®, Potassium-Pro™

DHEA

Vigor-Pro2™

Symprove®

Gerovital®

Prostate-Pro2™



A-Z INGREDIENT LIST

Pyroloquinoline quinone

Red clover herb extracts

Reminyl®

Resveratrol

Retinolic acid (tretinoin)

Ribonucleic acids (RNA)

Salicylic acid

S-Adenosyl-L-Methionine

Saw palmetto (SerenaRepens)

Selenium

Seligiline

Silver

Solasodine glycosides

Thiocynates

Thyroids

Thyrotropin releasinghormone

Tribulus terrestris

TRX

Turmeric

Ubiquinone, ubiquinol

VEGF

Vincamine

Vinpocetine

Vitamin B1 (thiamine)

Vitamin B2 (ribofl avin)

Vitamin B3 (niacin, niacinamide)

Vitamin B6 (pyridoxal,pyridoxine)

Vitamin B12 (cobalamin)

Vitamin C (ascorbic acid)

Vitamin E (tocopherols)

Vitamin K2 (menatretrenone)

Yohimbine

Zeolite

Zinc

PQQ

Prostate-Pro2™

Galantamine

Resveratrol-SR™, StemCell Worx®

Retirides®

NeyDent® toothpaste

BEC5 Curaderm®, Sol Answer™

SAMe

MinSaw™, Prostate-Pro2™

ACF228™, DIM-Pro2™,MZS™, Prostate-Pro2™,Selenium-Pro™,Thym-Uvocal®

Deprenyl

ACS®, Min-Mouth™mouth rinse

BEC5 Curaderm®, Sol-Answer™

1st Line™

Natural brands: Armour®,ERFA®, Nature®

Synthetic brands: Eutirox®

(T4), T3-Pro® (T3)

Supporting agents: Peptidebioregulator (Thyreogen®)

TRH

Andro-Pro™

Hair-Pro™

Curcumin

CoQ10

Hair-Pro™

Anacervix®

Vin-Pro™

Mito-Pro2™

Mito-Pro2™

Mito-Pro2™, Picamilone,Xan-Pro™

ACF228™, Andro-Pro™,DIM-Pro2™, pyridoxamine

DIM-Pro2™, Neo40®

MinSaw™, Neo40®

Can-C Plus™, DIM-Pro2™,Prostate-Pro2™

Bone-Pro2™

Vigor-Pro2™

ACZ®

Andro-Pro™, Can-CPlus™, Mito-Pro2™,MZS™, Thym-Uvocal®,Zinc-Pro™

57AGINGMATTERS

TESTIMONIALS

“IAS has shown great vision and leadership, as an organisation focused mainly on the provision of contemporary medical interventions against aging, and in also supporting the SENS Foundation’s eff orts to hasten the development of much more powerful future interventions.”

“IAS has a history of making throughout the world crucial, but diffi cultly accessible medications available to patients. IAS is one of the pioneering societies in antiaging medicine that has helped this new medical specialty move forward."

“Every adult has the right to take care of his or her own personal health as he or she chooses. In the 20th and 21st centuries, this universal human right has been nearly obliterated by an ocean of nanny-state regulation and deliberate suppression of information by bureaucracies, with hidden and not-so-hidden agendas. International Antiaging Systems is a beacon of useful health care information and a literal island of freedom of health care product choice in our otherwise un-free health care world.”

“I am a 77 year old Physician who has practiced medicine for nearly half a century. My antiaging research has permitted me to overcome serious health problems. Everyone can do this, but it requires specialized knowledge and the highest quality products. IAS is a vital link in my antiaging program because they continually provide both accurate information AND the high quality products we all require, if we are to achieve our maximum intended useful lifespan.

“IAS is an outstanding resource for the fi nest, most up-to-date news and information on healthy aging. They also off er products of the highest integrity and effi cacy. In fact, IAS is the world’s greatest source (often the only source) for the most cutting edge and advanced nutrients to ensure optimum healthspan and maximum life span.”

DR. AUBREY DE GREY

THIERRY HERTOGHE M.D.

JONATHAN WRIGHT M.D.

GARRY GORDON MD,DO,MD(H)

NICHOLAS PERRICONE M.D.

TESTIMONIALS


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WEBSITES

www.antiaging-systems.comwww.antiaging-nutrition.comwww.antiaging-nootropics.comwww.antiaging-peptides.comwww.antiaging-hormones.comwww.japanias.comwww.iasjp.com

(all of our products in one place; English language)(our nutritional products; English language)(our smart drugs and nutrients; English language)(our peptide bioregulators; English language)(our hormones; English language)(our nutritional products; Japanese language)(our medicines and hormones; Japanese language)

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TOMORROW’S TREATMENTS TODAY™


60ml liquid spray or dropper application.Maximum strength Minoxidil, plus IGF-1, bFGF and caffeine

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Onlne voucher code:MINMAX-5-OFF-0117

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61AGINGMATTERS

MARCH 2017 PRICELIST *

DIAGNOSTICS CONTAINS RETAIL PRICE$160 $149.99

FOODSAFE® NEW Blood spot food allergy test-kit for 95 foods $250 $239.99

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NATURAL MEDICATION FOR SKIN CANCER Dr Bill Cham 82 pages $19.99

PASSION, SEX, LONGEVITY & OXYTOCIN Dr. Thierry Hertoghe 159 pages $39.99

THE PHYSICIAN’S HORMONE HANDBOOK (VERSION 2) Dr. Thierry Hertoghe 833 pages $349.99

THE PICTURE ATLAS OF ENDOCRINOLOGY Dr. Thierry Hertoghe 327 pages $299.99

HORMONES CONTAINS OTHER INFO RETAIL PRICEALDOSTERONE

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DESMOPRESSIN

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DHEA

DHEA-25-PRO™ NEW 60 x 25mg capsules $20 $17.49

DHEA 7-KETO NEW 60x 100mg capsules $40 $34.99

ESNATRI™ (BIOIDENTICAL TRIPLE ESTROGENS)

ESNATRI™ 50ml 100mg (90-7-3%) jar cream $45 $39.99

HCG (HUMAN CHORIONIC GONADOTROPIN)

HCG-PRO™ 250IU/5ml nasal spray $60 $49.99

Please contact us for further details.

ITEM DETAILS OFFER

MEDICINES

HORMONESEsnatri™ (estrogens) 50ml 100mg cream Buy 3 and save $5.00 on each packT3-Pro™ (T3 thyroid) 50x 20mcg tablets Buy 3 and save $5.00 on each pack

Acarbose (Glucobay®) 30x 100mg chewables

PEPTIDESPEPTIDE BIOREGULATORS 20x capsules

SMART DRUGSCENTROPRO™ (CENTROPHENOXINE) 60x 250mg capsules Buy 3 and save $5.00 on each pack

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Stem Cell Worx® 3.5oz. liquid spray

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HYDROCORTISONE

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THYMUS

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63AGINGMATTERS


CIPROFLOXACIN

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DOXYCYCLINE

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DUTASTERIDE

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FINASTERIDE

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METFORMIN

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NALTREXONE (LDN)

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RASAGILINE

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REBOXETINE (DAVEDAX®)

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ROXITHROMYCINE

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SILDENAFIL (GENERIC VIAGRA®)

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STABLON® (TIANEPTINE)

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TETRACYCLINE

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VALDOXAN® (AGLOMELATINE)

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VENLAFAXINE

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NUTRITION CONTAINS OTHER INFO RETAIL PRICE1ST LINE™

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5HTP (5-HYDROXY-TRYPTOPHAN)

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ACF228®

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INHALER (BREATHE-EASY™) 1 complete kit $150 $134.99

AMINOGUANIDINE

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ANDRO-PRO2™

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MEDICINES CONTAINS OTHER INFO RETAIL PRICE



BETA-GLUCANS

BG-CREAM™ NEW 50ml tube cream $45 $39.99

BG-CAPS™ NEW 60x 400mg capsules $35 $29.99

BHT (BUTYLHYDROXYTOLUENE)

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CAN-C™ PLUS

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COQ10 (COENZYME Q10)

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CURCUMIN

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DMSA

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65AGINGMATTERS


MINERAL MOUTHWASH

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NADH

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NEO40®

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NICOTINAMIDE RIBOSID E

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OXALOACETATE

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RESVERATRO L

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TA65®

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PEPTIDES CONTAINS OTHER INFO RETAIL PRICEGHRP- 2

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GHRP-6

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SERMORELIN

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SMART DRUGS CONTAINS OTHER INFO RETAIL PRICEADRAFINIL

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ANIRACETAM

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CENTROPHENOXINE

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67AGINGMATTERS

MARCH 2017 PRICELIST *IDEBENONE

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PICAMILONE

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VINPOCETINE

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TOPICALS CONTAINS OTHER INFO RETAIL PRICEBEC5 CURADERM®

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CAN-C™ EYE-DROPS

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SERUM 30ml dropper bottle $90 $79.99

TONIC 200ml liquid bottle $45 $39.99

OTHERS CONTAINS OTHER INFO RETAIL PRICEINJECTION PACKS

INTRAMUSCULAR 30x syringes, wipes and sharps $30 $24.99

SUBCUTANEOUS 30x syringes, wipes and sharps $30 $24.99

SMART DRUGS CONTAINS OTHER INFO RETAIL PRICE

68 AGINGMATTERS

ONLINE CODE: AMINOPRO-3-OFF-0117

Offer Price: $14.49Aminoguanidine AminoProTM

(Usual Price: $17.49)

Restrictions may apply please see IAS terms and conditions for full details. Offer valid until 1st June 2017.


Turn back the clock with this potent

AGE* inhibitor

(AGE = advanced glycated end-products)

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