The 3rd International Symposium for Advanced Gel Materials...

Abstract Collection

第三届先进凝胶材料与软物质国际学术讨论会

The 3rd International Symposium for Advanced Gel Materials & Soft Matters

Jun. 14-17, 2019 Xi’an, China

The 3rd International Symposium for Advanced Gel Materials & Soft Matters (ISAGMSM),

Shaanxi University of Science and Technology, Xian, Shaanx Province, China.

June 14-17, 2019

2

PL 1

Future Subjects of Gel Science---inspired from biology................................................................... 1

PL 2

Functional Hydrogels Constructed from Natural Polymers .............................................................. 2

PL 3

DNA hydrogels ................................................................................................................................. 3

PL 4

Self-growing hydrogels by repetitive mechanical training ............................................................... 4

PL 5

Low-molecular Mass Compounds-based Gels and Gel Emulsions: From Aerogels to High

Performance Porous Monoliths ......................................................................................................... 5

PL 6

Photo-reactive polymers for medical applications ............................................................................ 6

PL 7

Mechanical stability of fiber networks .............................................................................................. 7

IL1-1

Polyampholyte Hydrogels with pH Modulated Shape Memory and Spontaneous Actuation ........... 8

IL1-2

Hydrogels with ultra-dynamic network enhance mechanosensing-dependent activities of

encapsulated stem cells ..................................................................................................................... 9

IL1-3

Mussel inspired cell/tissue adhesive hydrogels with multi-functions ............................................. 10

IL1-4

Underwater Microphones: Electric Double Layers at the Electrode-Gel Interface......................... 11

IL1-5

Bioinspired nucleobase-driven adhesive hydrogels with excellent underwater adhesion ............... 12

IL1-6

Mechanical reinforcement of soft matter: design of synthetic gels as model systems .................... 13

IL1-7

Bioinspired Chiral Supramolecular Hydrogels ............................................................................... 14

IL1-8

Multifunctional hydrogels for rapid hemostasis and tissue repair .................................................. 15

IL2-1

Highly Plasticized PVC Gel with Smart Functions Electrical, Optical, Mechanical - .................... 16

IL2-2

High Frequency dynamics of polymer solutions and gels studied by microrheology ..................... 17

IL4-1

Anisotropic composite gels from liquid crystalline nanosheets ...................................................... 18

IL4-2

Biomimetic shape-transformation of composite hydrogel films ..................................................... 19

IL 4-3

Active Gap Control of Gold Nanodots using Gels in Nanoscale .................................................... 20

IL 4-4



June 14-17, 2019

3

Anomalous expansion of clusters in percolation process in diluted system ................................... 21

IL 5-1

Ion-to-Ion Amplification through an Open Junction 1 Ionic Diode Jeong-Yun Sun ....................... 22

IL5-2

Active network of motor proteins as artificial dynamic microenvironment for cells ..................... 23

IL5-3

Functional modification, Controllable Fabrication and Biomedical Applications of natural polymer

Hydrogel ......................................................................................................................................... 24

IL5-4

Ultrastretchable Stress and Strain Sensors Based on Tough Conductive Hydrogels ...................... 25

IL5-5

Instabilities in soft materials: from gels to metamaterials ..................................................... 26

IL5-6

Stimuli-Responsive Smart Membranes ........................................................................................... 27

IL5-7

Construction of molecular swarm robot integrating biomolecular soft actuators and processors ... 28

IL5-8

Polysaccharide-based ionic hydrogel .............................................................................................. 29

OL 1-1

Super-elastic and multifunctional polymer hydrogel strengthened by low-content cement-released

nanoparticles ................................................................................................................................... 30

OL 1-2

OSA-AM hydrogel with high-strength and faster self-healing property from sodium alginate...... 31

OL 1-3

High Strength Globular Protein Hydrogels ..................................................................................... 32

OL 1-4

Multiple Functions of High Performance Hydrogels Enhancement by Hydrogen Bond ................ 33

OL 1-5

Predictions of Thermo‐Mechanical Properties of Cross‐Linked Polyacrylamide Hydrogels Using

Molecular Simulations .................................................................................................................... 36

OL 1-6

Solvent responsive ultra-strong shape memory gels based on hydrophobic association with fantasy

applications ..................................................................................................................................... 38

OL 1-7

Electroactive Hydrogels: synthesis, characterization and application ............................................ 39

OL 1-8

Highly-tough single-network polysaccharide hydrogel .................................................................. 40

OL 1-9

Molecular engineering of metal-coordination interactions for strong, tough and fast-recovery

hydrogels ......................................................................................................................................... 42

OL 1-10

Injectable Hydrogel Formed by Metal–Ligand Coordination Assembly as Biomaterials ............... 43

OL 1-11



June 14-17, 2019

4

Fabrication of chitosan functionalized graphene oxide-embedded nanocomposite hydrogels with

enhanced mechanical properties ..................................................................................................... 45

OL 1-12

Freezing-Tolerant Gelatin Organohydrogels with High Mechanical Performances,

Thermoplasticity, and Adhesivity .................................................................................................... 46

OL 1-13

Electrochemical analysis of bovine serum albumin imprinting CaAlg based composite hydrogel

sensor .............................................................................................................................................. 48

OL 1-14

Ultrastiff and tough hydrogels with dense and robust hydrogen bond complexes .......................... 49

OL 1-15

Anisotropic All-Cellulose 3D Wrinkled Hydrogels with Programmable Patterns for Cells

Alignment ....................................................................................................................................... 50

OL 1-16

An injectable self-assembling collagen-gold hybrid hydrogel for combinatorial antitumor

photothermal/photodynamic therapy .............................................................................................. 51

OL 1-17

PAM/CaAlg/CaSiO3@SiO2 composite hydrogel with high strength, good transparency and low

swelling under physiological environment ..................................................................................... 53

OL 1-18

Multicolor Fluorescent Polymeric Hydrogels: Fabrication and Sensing/Actuating applications ... 54

OL 1-19

Mechano-responsive, tough and antibacterial zwitterionic hydrogels with controllable drug release

for wound healing ........................................................................................................................... 56

OL 1-20

Macroscopic Supramolecular Assembly of Hydrogels Based on Host/Guest Polymer Brushes .... 57

OL 1-21

Natural Triterpenoid-Tailored Phosphate: In Situ Reduction of Heavy Metals Spontaneously to

Generate Electrochemical Hybrid Gels ........................................................................................... 58

OL 1-22

High-strength and Self-Healing Hydrogel Based on Carboxymethylcellulose ............................... 59

OL 1-23

Ultrastiff and Tough Supramolecular Hydrogels with a Dense and Robust Hydrogen Bond

Network........................................................................................................................................... 60

OL 1-24

Alginate-based hydrogel microcapsules for immobilized biocatalysis ........................................... 61

OL 2-1

Natural triterpene-tailored supramolecular gels: chiral transfer and amplification ......................... 62

OL 2-2

The “Morse Code” between Solvent Polarity and Morphology Flexibility .................................... 63

OL 2-3

Hierarchical Macroporous networks construct by Supramolecular chiral self-assembly of POSS

core dendrimers ............................................................................................................................... 64



June 14-17, 2019

5

OL 3-1

Nanocellulose Based Bio-scaffold Routed For Biomedical Applications ....................................... 65

OL 3-2

Controlled Self-Assembly of MXene-Polymer at Liquid/Liquid Interfaces ................................... 66

OL 3-3

“Stiff-Soft” Binary Synergistic Aerogels with Superflexibility and High Thermal Insulation

Performance .................................................................................................................................... 67

OL 3-4

Highly Porous Polymer Aerogel Film - Based Triboelectric Nanogenerators ................................ 68

OL 3-5

Graphene-crosslinked CNT aerogel for the preparation of elastic porous polymer composites ..... 69

OL 3-6

The Organic Acids Assisted Sol-Gel Method for Preparing Functional Aerogels .......................... 70

OL 3-7

Mesoporous Silica Nanoparticles as Nanocarriers for Controlled Pesticide Release ..................... 71

OL 4-1

Achieving Fracture-resistant Composite Hydrogels by Large Energy-dissipative Process Zones . 72

OL 4-2

Bio-inspired hydrogel/organogel materials with special adhesion .................................................. 74

OL 4-3

Mussel-Inspired Cellulose Nanocomposite Tough Hydrogels with Synergistic Self-Healing,

Adhesive, and Strain-Sensitive Properties ...................................................................................... 75

OL 4-4

Hollow hydrogel networks for temperature-controlled water fluidics ............................................ 76

OL 4-5

Deswelling behavior of pNIPAM composite gel consisting of nanosheet liquid crystal whose

orientation is controlled by asymmetric electric field ..................................................................... 77

OL 4-6

Strong and tough hydrogels with highly ordered and controllable microstructure ......................... 78

OL 5-1

Structural constructions and multi-functions of biodegradable polyurethanes ............................... 79

OL 5-2

Inducing Molecular Isomerization Assisted by Water..................................................................... 81

OL 5-3

Rational design of UCST polymers as functional materials guided by a thermodynamic map ...... 82

OL 5-4

Biocompatible photoluminescent silk fibers with stability and durability ...................................... 83

OL 5-5

From Shear-thickening Gel to Multifunctional Anti-impact Body Armor ..................................... 84

OL 5-6

A self-healing hydrogel with pressure sensitive photoluminescence for remote force measurement

and healing assessment ................................................................................................................... 86

OL 5-7



June 14-17, 2019

6

Controlled Phase Transitions of Dipeptide-based Gels ................................................................... 87

OL 5-8

Histidine-based Supramolecular π-gel: Dynamic Self-assembly and Controlled Switching of

Circularly Polarized Luminescence ................................................................................................ 88

OL 5-9

Biomimetic anisotropic hydrogel actuators..................................................................................... 89

OL 5-10

Bioinspired Soft Sensing and Actuating Materials ......................................................................... 90

OL 5-11

Hydrophobic Hydrogels with Fruit-like Structure and Functions ................................................... 91

P 1-1

Investigation of photo-crosslinkable injectable poly(vinyl alcohol) hydrogel for cartilage repair . 92

P 1-2

A highly stretchable conductive polymer hydrogel by freeze-thaw- shrink treatment for flexible

electrodes ........................................................................................................................................ 93

P 1-3

Peptide nanofiber hydrogels to vascularization in skin regeneration .............................................. 94

P 1-4

Anti-freezing ZwitterionicPoly(ionic liquid) hydrogel-based multimodal artificial skin ............... 95

P 1-5

Synthesis and properties of a Tough and multifunctional hydrogel based on grape seed polymer

........................................................................................................................................................ 96

P 1-6

Physically cross-Linked hydrogel with toughness, high stretchability, biocompatibility,

conductivity, and self-healability .................................................................................................... 97

P 1-7

Reverse Photochromic hydrogel with self-healing property for potential rewritable display

application ....................................................................................................................................... 98

P 1-8

CO2 sensitive self-supporting cellulose hydrogel as food spoilage indicator ................................. 99

P 1-9

Flexible semi-IPN network gel polymer electrolyte for supercapacitor ....................................... 100

P 1-10

All-in-one configured stretchable flexible supercapacitor with high strength, excellent

self-recovery and self-healing performances ................................................................................ 101

P 1-11

Complex Deformation of Bilayer Hydrogels Based on Shape Memory Hydrogel and Elastic

Hydrogel ....................................................................................................................................... 102

P 1-12

Hybrid Cross-linked Natural Protein Hydrogels with High Strength ........................................... 103

P 1-13

Body-Temperature Responsive Ultrafast Shape Memory Hydrogel Based on Natural Materials

...................................................................................................................................................... 104



June 14-17, 2019

7

P 1-14

One-Step Synthesis of Healable Weak-Polyelectrolyte-Based Hydrogels with High Mechanical

Strength, Toughness, and Excellent Self-Recovery ...................................................................... 105

P 1-15

Preparation and Properties of Nanocomposite Hydrogels Cross-linked by Alumina Nanoparticles

...................................................................................................................................................... 106

P 1-16

Tough hydrogels with strong, fast and reversible underwater adhesion........................................ 107

P 1-17

A Highly stretchable, tough and fast self-healing hydrogel based on peptide-metal ion

coordination .................................................................................................................................. 108

P 1-18

Asymmetric interpenetrating UCST polymer network as multiple-responsive hydrogel actuator 109

P 1-19

A shape memory hydrogel with editable permanent shape based on orthogonal supramolecular

interactions .................................................................................................................................... 110

P 1-20

Color-Tunable Fluorescent Supramolecular Metallogels Constructed by Lanthanide (Eu/Tb)

Dependent Coordination Interaction ............................................................................................. 111

P 1-21

Tough Lignin Bonded Hydrogels with Tunable Mechanical Properties ....................................... 112

P 1-22

Reinforcement of gelatin hydrogel by heat-induced phase separation .......................................... 113

P 1-23

Dual physically cross-linked double network hydrogel with high toughness and self-healing

capability ....................................................................................................................................... 114

P 1-24

Control of ice crystal growth and its effect on porous structure of chitosan cryogels .................. 115

P 1-25

In-situ forming thermosensitive polyurethanes-based hydrogel crosslinked by Diels-Alder reaction

for 3D cell culture ......................................................................................................................... 116

P 1-26

Shape memory hydrogel based on sodium alginate crosslinked by double networks................... 117

P 1-27

Highly adhesive and stretchable photothermal hydrogels for preventing postoperative recurrence

of cancer ........................................................................................................................................ 118

P 1-28

Sulfonated MXene Nanocomposite Hydrogels for Self-healing, Adhesive and Conductive

Properties ...................................................................................................................................... 119

P 1-29

Research on Gel Analyzer Based on Image Processing ................................................................ 120

P 1-30

Preparation of keratin-based polymer hydrogel with double sensitivity for drug releasing ......... 121



June 14-17, 2019

8

P 1-31

Facile preparation and enhanced stretchableperformance of self-assembled polyelectrolytes-based

composite hydrogels ..................................................................................................................... 122

P 1-32

Tough, antibacterial and antifouling double network hydrogels based on hybrid ionic-covalent

crosslinking* ................................................................................................................................. 124

P 1-33

Double cross-linking the second network of DN hydrogel for tough sensitive strain and pressure

sensors ........................................................................................................................................... 125

P 1-34

Synthesis and swelling properties of superporous anionic hydrogel based polyvinyl

alcohol-formaldehyde sponges ..................................................................................................... 127

P 1-35

Biotribology behavior of UHMWPE grafted with PVA/HA composite hydrogel as artificial

cartilage materials ......................................................................................................................... 128

P 1-36

Internal Damage Evolution in Double-Network Hydrogels Studied by Microelectrode Technique

...................................................................................................................................................... 130

P 1-37

Programmed deformations of 3D printed tough physical hydrogels with metal-coordination

complexes ..................................................................................................................................... 131

P 1-38

Programmed multi-stable configurations of composite hydrogels with in-plane and

through-thickness gradients .......................................................................................................... 132

P 1-39

Mechanical Property of Polyelectrolyte Networks ....................................................................... 133

P 2-1

Adhesive, self-healable, and transparent micro-crosslinked organogels as flexible sensor .......... 134

P 2-2

Highly Stretchable, Electrically Conductive and Temperature Tolerant Ionogels for Flexible

Sensors .......................................................................................................................................... 135

P 2-3

A Shorter Alkyl Chain Dominated Self-Assembly of Homochiral Nanotubes in Heterochiral Lipid

Organogels .................................................................................................................................... 137

P 2-4

Anti-freezing, non-drying tough organohydrogel with good flexibility and conductivity ............ 138

P 2-5

Organic or inorganic crystallization in functional molecular gels ................................................ 139

P 3-1

Oil-water separation, Lightweight, Flexible and Thermally-Insulating Aerogels Derived from

wood Nanofibrillated Cellulose .................................................................................................... 140

P 3-2

Preparation and characterization of ultra-fast Temperature-responsive nanofibrous hydrogel ..... 142



June 14-17, 2019

9

P 3-3

Cu/Cu2O/CuO Nanoparticles Loaded on Porous Carbon from a Novel Hypercrosslinked Porous

Polymer for Catalytic Reduction of 4-Nitrophenol ....................................................................... 143

P 3-4

Synthesis of leafy-shape TiO2-C nanosheets by alkaline treatment of Ti3C2Tx MXene ............... 144

P 3-5

Removal of Perrhenate using Radiation Synthesized Hierarchically Macro/Mesoporous

Silica-gratft-Quaternary Phosphonium ......................................................................................... 146

P 3-6

Zein-based composite film with pH-sensitivity for drug controlling release ................................ 148

P 3-7

Zein-based magnetic polymer aerogel as oil absorbing agent ...................................................... 149

P 3-8

Microstructure and mechanical properties of aerogels prepared by Freeze casting ...................... 150

P 3-9

Controlled preparation of Nitrogen-doped carbon cryogels with excellent carbon dioxide

adsorption performance ................................................................................................................. 151

P 4-1

Ionically Cross-Linked Silk Microfibers/Alginate Tough Composite Hydrogels with Hierarchical

Structures ...................................................................................................................................... 152

P 4-2

Effects of zein on the formation of konjac glucomannan electrospun nanofibres for controlled

release of curcumin ....................................................................................................................... 159

P 4-3

Zein-based composite film with pH-sensitivity for drug controlling release ................................ 160

P 4-4

Synthesis of self-supporting composite nanowires based on 3D-network metallogel template ... 161

P 5-1

Freeze and Heat-Resistant, Nonflammable and Highly Robust Ionic Liquid-Based Click-Ionogels

...................................................................................................................................................... 162

P 5-2

Molecular dynamics simulation of rupture mechanism in nanofiller filled polymer nanocomposites

...................................................................................................................................................... 163

P 5-3

Research and application of implantable blood detection device based on shape memory polymer

...................................................................................................................................................... 165

P 5-4

Stretchable resistance sensor based on liquid metal direct writing method .................................. 166

P 5-5

Ionoprinting controlled information storage of fluorescent hydrogel for hierarchical and

multidimensional decryption ......................................................................................................... 167

P 5-6

Multifunctional Wearable Sensors based on Repairable and Recyclable Carbon Nanotubes



June 14-17, 2019

10

Conductive Hydrogel .................................................................................................................... 168

P 5-7

Autonomous swarming of biomolecular robots utilizing the sequential signaling of DNA ......... 169

P 5-8Super-elastic and multifunctional polymer hydrogel strengthened by low-content cement-released nanoparticles ..................................................................................................................................170



June 14-17, 2019

1

PL 1

Future Subjects of Gel Science---inspired from biology

Yoshihito OSADA

RIKEN, Wako, Saitama, 351-0198, Japan

[email protected]

Gel is a main constituent of biology and its science is extremely wide and

borderless spreading to life science. One of the ultimate goals of gel science is to

create hydrogels with “Emergent Functions” which biological soft tissues possess and

eventually to replace them. In this connection, we have to learn real structure to

reveal their functions from biology.

In this talk several important research subjects in gel science to be investigated

in future will be given. They include some of the following topics.

1 Mechanically Strong Hydrogel with Tissue- like Structure

2 Mechanism and Creation of Bio-Interface

3 Water in the Gel -- Its Unusual behaviors

4 Nano-kinetics in the Gel

5 Emergent Function through Hierarchical Gel

6 Ionics and Electronics

mailto:[email protected]



June 14-17, 2019

2

PL 2

Functional Hydrogels Constructed from Natural Polymers

Lina Zhang*, Xichao Liang, Dongdong Ye, Kunkun Zhu, Jiangjiang Duan

College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072,

China.

[email protected].

Faced on the increasing consumption of non-renewable fossil resources and the

increasingly serious environmental pollution caused by non-degradable plastics,

renewable biomass polymers show great application prospects, because their safety

and biodegradability. We have developed new solvents, alkali/urea aqueous solutions

with cooling, to dissolve cellulose, chitin and chitosan, resulting in a transparent

natural solution. Herein, by reducing nanofibrous formation through the “bottom to

up” method, a series of cellulose, chitin and chitosan based functional hydrogels were

successfully constructed as follows. (1) Novel chitosan/carrageenan polyelectrolyte

composite hydrogels with high strength and toughness were constructed based on the

electroneutral behavior of chitosan in alkali/urea aqueous solvent system, showing the

application prospects in the cartilage repair. (2) Bilayer hydrogels with temperature

and pH responses were prepared by utilizing the pH sensitivity of chitosan hydrogel.

(3) Mechanically strong nanofibril-structured chitosan hydrogel was fabricated via

simply drawing, which can guide directional growth of the cells. (4) A robust and

conductive hydrogel with high strength, ultra-stretchability and force-sensitivity was

fabricated through multiple interpenetrating networks in the chitosan microspheres,

which could be an ideal candidate for electronic skin devices. (5) Chitin hydrogels

cross-linked with epichlorohydrin in alkali/urea aqueous solution were used for the

soilless cultivation of rapeseed, showing good seed germination and growth. (6)

Robust anisotropic cellulose hydrogels were fabricated from cellulose solution

through pre-stretching strategy in chemical gel state and then locking the highly

ordered nanostructure via strong self-aggregation forces, which could induce the

directional growth of cardiomyocytes. These natural polymer-based functional

hydrogels have potential applications in the fields of biomedicine, sensor and

agriculture etc.

Acknowledgements This work was supported by the Major International (Regional)

Joint Research Project of National Natural Science Foundation of China

(21620102004).



June 14-17, 2019

3

PL 3

DNA hydrogels

Dan Luo, PhD, Professor

Cornell University, Ithaca, NY 14850, USA

[email protected]

Believing in the concept that DNA is a true polymer. over the last almost 20 years,

my group at Cornell University has been engineering DNA molecules as both a

genetic and a generic building block. Indeed, DNA is an amazing polymer with more

than four thousand nanoscale processing tools that no other polymers have. In this talk,

I will focus on how we have designed and developed DNA-based hydrogels for

real-world applications from diagnostics to pharmaceutics. More specifically, I will

elaborate on the creation of the first-ever, all-DNA hydrogel and from which a

protein-producing DNA hydrogel (termed P-gel). Besides the chemical crosslinked

DNA hydrogels, a physical, entangled DNA hydrogel was also invented in my group.

This type of DNA hydrogel has the meta-property in that the hydrogel is both a liquid

and a solid. Our DNA P-gel may lead towards the realization of synthetic cells while

our meta-DNA hydrogel may become a super condensed ultra-compact DNA

(scudDNA) for the direct delivery of DNA-based therapeutics. Recently, we have also

created a new type of hydrogel: life-like DNA hydrogels that possessed metabolic

activities while at the same time were able to move autonomously against flow. Two

such DNA hydrogels raced against each other. Other novel, large scale DNA

hydrogels will also be discussed. We envision that DNA hydrogels will become an

important, versatile, and sustainable material for the world in the near future.



June 14-17, 2019

4

PL 4

Self-growing hydrogels by repetitive mechanical training

Takahiro Matsuda1, Ryo Namba1, Tasuku Nakajima2,3,4, Jian Ping Gong2,3,4

(1Graduate School of Life Science, Hokkaido University; 2Faculty of Advanced Life Science,

3Soft Matter GI-CoRE, 4WPI-ICReDD, Hokkaido University, Japan. )

Living tissues, such as muscle, autonomously grow and remodel themselves to adapt to

their surrounding mechanical environment through metabolic processes. By contrast,

typical synthetic materials cannot grow and reconstruct their structures once formed.

We present a strategy for developing “self-growing” polymeric materials that respond

to repetitive mechanical stress through an effective mechanochemical transduction in

the robust double network hydrogels [1]. We show that the double-network hydrogels,

with supply of monomers, self-grow and significantly strengthen under repetitive

loading. Such sustained self-growing is through a repetitive structural destruction and

reconstruction process, in analogy to the metabolic processes of biological system.

This strategy also endows to impart the hydrogels with tailored functions at desired

positions by mechanical stimuli. This work may pave the way for the development of

self-growing gel materials for applications such as soft robots and intelligent devices.

References:

1. Jian Ping Gong, Soft Matter, 6(12), 2583-2590(2010).

2. Takahiro Matsuda, Runa Kawakami, Ryo Namba, Tasuku Nakajima, Jian Ping

Gong, Science, 363(6426), 504-508 (2019).



June 14-17, 2019

5

PL 5

Low-molecular Mass Compounds-based Gels and Gel Emulsions:

From Aerogels to High Performance Porous Monoliths

Yu Fang

（Key Laboratory of Applied Surface and Colloid Chemistry, School of Chemistry and Chemical

Engineering, Shaanxi Normal University, Xi’an 710119, China）

*E-mail: [email protected]

Compared to conventional chemical and polymers-based physical gels, molecular gels

based on low-molecular mass compounds are more sensitive to external stimuli,

demonstrating reversible flowability change and phase transition. It is the property that

makes molecular gels acquire a variety of important applications. In this talk, I will focus

on extension of molecular gel studies to gel-emulsions and the relevant template

preparation of porous polystyrene monoliths. As will be presented, the volume fraction of

the dispersed phase in the new concept gel-emulsions could be much lower than the

well-known limit of 74% of conventional ones. A possible reason behind is the using of

low-molecular mass gelators as stabilizers, which gels the continuous phase. In other

words, gel-emulsions have changed from conventional bis-liquid to liquid-gel systems,

implying that the systems lost their flowability not because of dispersed phase crowding,

but because of physical trapping. As will be demonstrated through case studies, remove

of the restriction has largely extended the application of gel-emulsions in template

preparation, allowing creation of porous materials from light-weight aerogels to

low-density high strength monoliths. Recent progress in the studies of other gel-related

dynamic systems may be also presented provided time is allowed.

Keywords: Molecular gels, Gel-emulsions, Template preparation, Porous monoliths

References:

Adv. Mater. 2019, 31, 1808254; Macromolecules 2019, 52, 2456-2463; Soft Matter 2018, 14,

7950-7953; Macromol. Rapid Commun. 2018, 39, 1700679; Chem. Eng. J. 2018, 339, 14-21; J.

Mater. Chem. C, 2018, 6, 12493-12497; Chem. Mater. 2017, 29, 5957-5964; Langmuir 2017, 33,

10419-10428 (Invited Feature Article); Macromol. Rapid Commun. 2017, 38, 1700270- 1700274;

Mol. Syst. Des. Eng. 2016, 1, 242-257; ACS Appl. Mater. Interfaces 2016, 8, 18584-18592; J.

Mater. Chem. A 2015, 3, 24322-24332; ACS Appl. Mater. Interfaces 2015, 7, 10718-10726; Soft

Matter 2014, 10, 9159-9166; Langmuir 2014, 30, 13680-13688; J. Mater. Chem. A2014, 2,

10081-10089; Chem. Commun.2014, 50, 13940-13943; J. Am. Chem. Soc. 2013, 135, 8989-8999;

Soft Matter2013, 9, 1091-1099; Soft Matter2013, 9, 5807-5814; Langmuir2013, 29, 793−805; J.

Mater. Chem. A2013, 1, 10135-10141



June 14-17, 2019

6

PL 6

Photo-reactive polymers for medical applications

Yoshihiro Ito 1,2

（1Nano Medical Engineering Laboratory, RIKEN Cluster for Pioneering Research, 2-1

Hirosawa, Wako-shi, Saitama 351-0198, Japan; 2Emergent Bioengineering Materials Research

Team, RIKEN Center for Emergent Matter, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan）


We have been developed two types of photo-reactive polymers for medical

applications. One is visible-light cross-linkable biological polymers. Another is

UV-curable polymers.

The visible-light reactive polymers consisted of gelatin, alginate, and chitosan

and they were prepared by coupling with furan group. In the presence of non-toxic

photosensitizers such as Rose Bengal and riboflavin, the conjugated furan produced

oxides by visible-light irradiation and reacted with others. They have been applied as

scaffolds for tissue engineering or bioadhesives.

Another UV-reactive polymer was prepared by coupling with azidophenyl group.

Gelatin was coupled with the photo-reactive group and the conjugate was used for

micropattern-immobilization of growth factors. The micropatterning was useful to

investigate the effect of immobilized growth factor. Another utilization is for

microarray immobilization with non-biofouling polymers. The photo-immobilization

is all-round one because immobilization mechanism is based on radical reactions The

immobilized microarray has been used for multiple detection of bio-markers.

Keywords: Photo-reactive, Cross-linking, Medical Adhesive, Immobilization

References:

[1]. Yoshihiro Ito, ed. “Photochemistry for Biomedical Applications”,

Springer-Nature (2018)



June 14-17, 2019

7

PL 7

Mechanical stability of fiber networks

Miklos Zrinyi, Evelin Sipos, Akos Juhasz

Laboratory of Nanochemistry, Department of Biophysics and Radiation Biology,

Semmelweis University, H-1089, Nagyvárad tér 4. Hungary

Email: [email protected]

Fibrous materials have important technological applications owing to their

excellent mechanical performance and low weight. The mechanical properties of fibre

assemblies depends on the strength and the toughness of single fibres as well as on

their geometrical arrangement. The mechanical behavior of fibrous materials deviates

significantly from that of traditional materials because of the discontinuous nature of

randomly distributed fibres. Despite their high strength, little information is available

about the deformation mechanism of spun fabrics; the load bearing capacity of these

materials critically affects many technological and biomedical applications.

This work presents the results of unidirectional strain-controlled experiments on

fibrous electrospun networks used to study damage formation during elongation. The

experimental loading curve shows a symmetrical parabolic type dependence at large

scale and saw tooth-like forceextension behaviour at small scale. The damage

formation was quantified by determining the number and the magnitude of abrupt

force drops. The experiments evidenced that damage evolution is a consequence of

strain induced random events. The frequency distribution of the number of damages

as well as the magnitude of rupture force were experimentally studied and compared

with computer simulation. The results provide a better insight into damage tolerance

and complex nonlinear tensile properties of electrospun networks.

Keywords: Fiber networks, Fiber Bundle Model, Electrospinning, Damage formation




June 14-17, 2019

8

IL1-1

Polyampholyte Hydrogels with pH Modulated Shape Memory and

Spontaneous Actuation*

Yuancheng Zhang, Jiexin Liao, Tao Wang*, Weixiang Sun, Zhen Tong*

(Research Institute of Materials Science, South China University of Technology

Guangzhou 510640, China)

E-mail: [email protected]

Generally, the temporary shape of shape memory polymers is formed by an

external force and fixed by some reversible interactions, which are triggered at the

conditions gentler than that maintaining the permanent shape. For the hydrogels,

the special circumstance is that plenty of water inside promotes the polymer chain

motion and weakens the temporary shape fixation. On the other hand, all of the

actuations are one-off, and the original shape cannot convert to the temporary shape

spontaneously and reversibly. For reversible alternation between the original and

temporary shapes, the hydrogels are usually fabricated with anisotropic structures to

transfer the isotropic volume expansion into anisotropic movements. However,

these usually require complicated preparation or/and external control devices. The

spontaneous shape change from the original to temporary is essential for a continuous

actuation.

We synthesized polyampholyte hydrogels consisting of strong cationic

monomer with both strong and weak anionic monomers without chemical crosslinker

and adding salts. The hydrogels exhibited pH responsive shape memory: the

temporary shape was formed manually after immersing in NaOH solution and fixed in

HCl solution, while the shape recovery occured by immersing in NaOH again.

Most interestingly, the hydrogel showed a spontaneous shape change after the first

shape memory cycle. When the recovered hydrogel with a little residual

deformation was immersed in HCl again, it twisted spontaneously and rapidly to the

previous temporary shape. The spontaneous twisting and recovering can be

repeated for 10 times by alternately immersing in NaOH and HCl solutions without

any external force. Furthermore, the hydrogel swelled quickly and was

strengthened in HCl, while shrank and weakened in NaOH during the shape change

procedure. This unique synergistic effect of fast swelling, residual helical

deformation, and increased strength played a significant role to the spontaneous shape

alternation.

Keywords: Polyampholyte hydrogels, Spontaneous actuation, Shape memory

* This research was supported by the NNSFC (21427805).



June 14-17, 2019

9

IL1-2

Hydrogels with ultra-dynamic network enhance

mechanosensing-dependent activities of encapsulated stem cells

Liming Bian1†, Boguang Yang1, Kongchang Wei1

（1 Department of Biomedical Engineering, Chinese University of Hong Kong, Hong Kong,

China）


In living organisms, cells are constantly interacting with and remodeling the highly dynamic

extracellular matrix (ECM), and this process enables various cell behaviors including

proliferation, migration, and differentiation[1]. The dynamic properties of the natural ECM

primarily stem from two orthogonal sources, the enzymatic degradation of biopolymers and the

force-induced dissociation/re-association of physical crosslinks in the biopolymer network.

The latter typically operates at a significantly shorter timescale and higher frequency than the

former, thereby giving rise to the temporal hierarchy of ECM dynamic behaviors. However, the

natural ECM is highly complex, and precisely manipulating its dynamic properties remains

difficult. Therefore, designing a three-dimensional (3D) polymeric matrix with tunable

dynamic properties to recapitulate this temporal hierarchy of ECM dynamics is of great

importance for decoupling the effects of 3D matrix dynamics on cell behaviors. Our

supramolecular hydrogels (HGHA) crosslinked by engineered multivalent host-guest

complexations possess ultra-high network dynamics as revealed by relaxation spectra and

dynamic rheological analysis. Our data showed that HGHA hydrogels with decorated RGD

peptides supported ultra-rapid (within 18 h post encapsulation) stellate spreading of the

encapsulated hMSCs. The ultra-rapid cell spreading was supported by the formation of a cell

adhesion structure rich in β1 class integrins and led to enhanced activation of mechanosensing

factors, including FAK phosphorylation and YAP nuclear translocation. Consequently,

compared with control hydrogels with less dynamic structures, the HGHA hydrogels

significantly enhanced mechanotransduction-dependent hMSC osteogenic differentiation.

Keywords: hydrogels, stem cells, 3D culture, mechanotransduction

References:

[1] O. Chaudhuri, L. Gu, D. Klumpers, M. Darnell, S.A. Bencherif, J.C. Weaver, N. Huebsch, H.P. Lee,

E. Lippens, G.N. Duda, D.J. Mooney, Hydrogels with tunable stress relaxation regulate stem cell fate

and activity, Nat Mater 15(3) (2016) 326-34.




June 14-17, 2019

10

IL1-3

Mussel inspired cell/tissue adhesive hydrogels with multi-functions

Xiong LU (鲁雄)

Presenting Author, Authors (Time New Roman, 12 point)

Key Lab of Advanced Technologies of Materials, Ministry of Education, School of

Materials Science and Engineering, Southwest Jiaotong University,

Chengdu 610031, Sichuan, China

西南交通大学材料科学与工程学院，材料先进技术教育部重点实验，四川成都 610031)


Hydrogels are attractive biomaterials owing to their high water content and structural

resemblance to natural soft tissue. Intense efforts have been devoted to synthesizing hydrogels

for soft tissue repair, which requires not only toughness, but also cell affinity, tissue

adhesiveness, and self-healing ability. However, the commonly reported tough hydrogels lack

cell affinity and tissue adhesiveness, and therefore can not fully meet requirements of the

practical applications. Recently, mussel-inspired chemistry sheds new light on the

development of hydrogels with good cell affinity and tissue adhesiveness.

In this study, we report a series of mussel inspired hydrogel that simultaneously possess

those properties by incorporating various nanocomponents in the hydrogels, such as graphene,

CNT and nano clay. The hydrogel have super stretchability and high toughness. In addition,

the hydrogel has metal-free the self-healing ability, which can self-heal under the ambient

environment without other external stimuli. The hydrogels also possess good affinity to cells

and high adhesiveness to tissues, which can induce skin tissue regeneration for repairing full

skin defect. The tough hydrogel with cell affinity, tissue adhesiveness, and self-healing is an

excellent candidate for repairing the damaged tissue that withstands fatigue under cyclic

loading. In summary, the hydrogel could serve as a universal platform to incorporate many

types of functional NPs, resulting in hydrogel with multiple functionalities, such as magnetic

and conductive response properties. It might have broad applications in tissue engineering,

such as load-bearing cartilage, tendon and artificial skin. This development of this hydrogel is

a giant step forward for the practical applications of tough hydrogels

Keywords: mussel inspired, hydrogel, adhesive, tough

References:

[1] Lu Han, Xiong Lu*, et al , Adv. Funct. Mater. 2018, 28 (3) 1704195,

[2] Donglin Gan, Xiong Lu*, et al Adv. Funct. Mater. 2019, 29, 1805964

[3] Donglin Gan, Xiong Lu*, et al Nature Communications 2019




June 14-17, 2019

11

IL1-4

Underwater Microphones: Electric Double Layers at the

Electrode-Gel Interface

Meixiang Wang1, Xuejing Shen2,3, Xueqi Zhao1, Shichao Li2,3, Michael Sealy3,

Zhanjun Wu2, Yongmei Chen1,4*, Qin Zhou3*, and Li Tan3*

1Xi’an Jiaotong University; 2Da’lian University of Technology; 3University of

Nebraska-Lincoln; and 4Shaan’xi University of Science and Technology.

Electrically when a block of hydrogel is brought into contract with an electrode, an

electric double layer (EDL) forms at their interface. One unique property of EDL is

its large capacitance, which provides the foundation for supercapacitors. If the

capacitance can somehow be tuned by external mechanical stimuli such as acoustic

waves, an extremely sensitive transducer can be made. We show that the

transduction mechanism can either be introduced by the implantation of silver

nanotrees or by placing a block of hydrogel next to a single-atom-thick graphene.

Both approaches, however, involve electrochemical reactions at the gel-electrode

interface. We reveal that a simple replacement of hydrogel with ionic liquid gel is

not effective; rather, a deep understanding of EDL will pave the way, ultimately

resulting in much improved sensor lifetime and signal-to-noise ratio for those

underwater microphones.



June 14-17, 2019

12

IL1-5

Bioinspired nucleobase-driven adhesive hydrogels with excellent

underwater adhesion

Guang Hui Gao‡, Xin Liu, Qin Zhang

（Polymeric and Soft Materials Laboratory, School of Chemical Engineering and Advanced

Institute of Materials Science, Changchun University of Technology, No. 2055, Yan'an Street,

Changchun, P. R. China）


Bio-inspired strategies for designing hydrogels with excellent adhesive

performance have drawn much attention in biomedical applications. In our works,

bioinspired adhesive hydrogels tackified by independent nucleobase (Adenine,

Thymine, Guanine, Cytosine and Uracil) from DNA and RNA are successfully

explored. The nucleobase-tackified hydrogels exhibit an excellent adhesive behavior

for not only various solid substrates (polytetrafluoroethylene, plastics, rubbers, glasses,

metals and woods), but also biological tissues consisting of heart, liver, spleen, lung,

kidney, bone and muscle. However, it is still demanding to construct a tough

underwater gel-based adhesive completely based on the chemical constitution.

Inspired by the underwater adhesion mechanism of marine organism, the underwater

adhesive behavior is skillfully regulated through hydrophobic aggregation induced by

solvent exchange. The adhesive gels exhibit an excellent adhesive behavior for

various materials in the air and various aqueous solutions, including deionized water,

seawater, acid and alkali solutions (pH=3 and 10). It is anticipated that the bioinspired

nucleobase-tackified strategy would open a novel avenue for designing the next

generation of soft and adhesive materials.

Keywords: Hydrogels, Nucleobase, Underwater adhesion

References:

[1] Liu X; Zhang Q; Gao G*, Adv. Funct. Mater. 2017, 27, 1703132.

[2] Liu X; Zhang Q; Duan L; Gao G*, Adv. Funct. Mater. 2019, 1900450.

[3] Liu X; Zhang Q; Duan L; Gao G*, ACS Appl. Mater. Interfaces, 2019, 11, 6644.

This research was supported by the National Natural Science Foundation of China (Grant No.

51873024 and 51703012).

mailto:9%[email protected]



June 14-17, 2019

13

IL1-6

Mechanical reinforcement of soft matter: design of synthetic gels as

model systems

Alba Marcellan1,2

（1Soft Matter Sciences and Engineering, ESPCI Paris, PSL University, Sorbonne University,

CNRS, F-75005 Paris, France ; 2Global Institution for Collaborative Research and Education,

Global Station for Soft Matter, Hokkaido University, Sapporo, Japan)


By using concepts of polymer physics, we developed some strategies1-2 to design

tough “hybrid” gels that combine covalent (permanent) cross-links and physical

(reversible) sacrificial interactions. Recently, a novel mode of fracture toughening by

crack bifurcation has been highlighted in phase-separated hydrogels3-4. We designed

original gel topologies that phase-separate at constant macroscopic volume and quite

high level of hydration, independently of the phase-separation process. The polymer

network combines a conventional network with thermo-responsive domains which act

as reinforcing fibers operating at a targeted temperature. Network topology is crucial

to enhance efficiently the fracture resistance of the gels.

Figure. Impact of gel topology on fracture properties, from Ref. [3].

PNIPAm and PDMA are pictured in red and blue, respectively.

Keywords: Phase-separated Gels, Self-recovery, Fracture toughening

References:

[1]. Rose, Dizeux, Narita, Hourdet, Marcellan*, Macromol. 2013, 46, 4095

[2]. Rose, Prevoteau, Elziere, Hourdet, Marcellan, Leibler, Nature 2014, 505, 382

[3]. Guo, Sanson, Hourdet, Marcellan, Adv. Mater. 2016, 28, 5857

[4]. Guo, Mussault, Brulet, Marcellan, Hourdet, Sanson, Macromol. 2016, 49, 4295




June 14-17, 2019

14

IL1-7

Bioinspired Chiral Supramolecular Hydrogels

Chuanliang Feng§, Xiaoqiu Dou, Jinying Liu

State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, 800

Dongchuan Road, Shanghai 200240, China.


Chirality is one of life’s most distinctive biochemical signatures and has great

influence on many biological events. So far, the researches are mainly confined to the

role of molecular chirality on two dimensional (2D) surface and a lot of questions

remaining to be answered. Among them, how nanofibrous chirality influences cell

behaviors in three dimensional (3D) extracellular matrix (ECM) is especially

important, since it is only the 3D ECM nanofibrous structure can really mimick the

necessary biophysical environment for tissue engineering and helical nanofibrous

structure is closely related with relevant biological events. To overcome this issue, the

candidate has proposed a novel material design of constructing sandwich-like chiral

molecular structure that can achieve chiral transformation from molecular level to

macroscopic level, leading to the formation of highly ordered self-assembled hydrogel

biomaterials with helical chiral features. Moreover, it was revealed that left-handed

hydrogel can promote cell adhesion and proliferation. Based on these results, an

antibacterial ointment that can cure skin ulcer caused by diabetes has been developed.

This research paves innovative ways to develop new generation of biomaterials in the

fields of tissue engineering and biomedicine.

Keywords: Gelators, Hydrogels, chirality, self-assembly, cells

References:

[1] Liu J; Yuan F; Ma X; Auphedeous D; Zhao CL; Liu CT; Shen CY; Feng CL,*

Angew. Chem. Int. Ed., 2018, 57, 6475-6479.

[2] Wang F; Feng CL,* Angew. Chem. Int. Ed., 2018, 57, 5655-5659.

[3] Choi H; Cho K; Seo H; Ahn J; Liu J; Lee SS; Kim H;* Feng CL;* JungJH*, J. Am.

Chem. Soc. 2017, 139, 17711-17714

[4] Dou XQ; Feng CL,* Adv. Mater. 2017, 29, 604062.


51833006, 51573092).

http://pubs.acs.org/author/Choi%2C+Heekyoung

http://pubs.acs.org/author/Cho%2C+Kang+Jin

http://pubs.acs.org/author/Seo%2C+Hyowon

http://pubs.acs.org/author/Ahn%2C+Junho

http://pubs.acs.org/author/Liu%2C+Jinying

http://pubs.acs.org/author/Lee%2C+Shim+Sung

http://pubs.acs.org/author/Kim%2C+Hyungjun

http://pubs.acs.org/author/Kim%2C+Hyungjun

http://pubs.acs.org/author/Jung%2C+Jong+Hwa

http://pubs.acs.org/author/Jung%2C+Jong+Hwa



June 14-17, 2019

15

IL1-8

Multifunctional hydrogels for rapid hemostasis and tissue repair

Baolin Guo**

（Frontier Institute of Science and Technology, Xi’an Jiaotong University, Xi’an 710049, China）


Uncontrolled bleeding results in more than 30% of traumatic deaths. Although currently used

hemostatic agents exhibit excellent performance in hemostasis of limb surface wounds, they

generally have a poor hemostatic effect on deep wound bleeding. We prepared chitosan

derivatives and carbon nanotube materials to form injectable shape memory nanocomposite

porous gelatin hemostatic materials. Chitosan derivatives can provide good hemostatic

properties, promote wound healing and blood-triggered shape memory recovery. Due to the

rapid blood absorption, blood concentration and rapid blood-triggered shape recovery of the

composite gel, as a physical filling barrier with sufficient mechanical properties, it exhibits

excellent performance in rabbit liver volume loss and incompressible hemorrhage death

model.

After the bleeding stops, the severe skin defect of the skin is a serious threat to people's health

and life. At present, most of the injectable gel dressings have only a single biological activity,

which limits their multiple promoting effects on wound healing. We have reported an

injectable hydrogel dressing that has both self-healing and high adhesion. The in-situ gelation

and tissue adhesion properties of the hydrogel can quickly seal any shape of the wound to

provide a physical barrier, while the hemostatic and antibacterial properties of the gel can

allow the wound to stop bleeding quickly and prevent wound infection. Thus, the hydrogel

has great potential as a bioactive dressing in wound healing applications.

Keywords: Hemostasis; skin repair; muscle repair; conductive biomaterials; hydrogel

References: [1] X Zhao, B Guo*, H Wu, Y Liang, PX Ma*, Nature Communications, 2018, 9:

2784. [2] Y Wu, L Wang, B Guo*, PX Ma, ACS Nano, 2017, 11 (6), 5646-5659. [3] L Wang, Y

Wu, B Guo*, PX Ma, ACS Nano, 2015, 9 (9), 9167-9179. [4] J Qu, X Zhao, Y Liang, T Zhang,

PX Ma, B Guo*, Biomaterials, 2018, 183, 185-199. [5] X Zhao, H Wu, B Guo*, R Dong, Y Qiu,

PX Ma, Biomaterials, 2017, 122, 34-47. [6] Y Wu, L Wang, B Guo*, Y Shao, PX Ma,

Biomaterials, 2016, 87, 18-31.


51673155).



June 14-17, 2019

16

IL2-1

Highly Plasticized PVC Gel with Smart Functions Electrical, Optical,

Mechanical -

Toshihiro HIRAI††

（Fiber Innovation Incubator, Faculty of Textile Science and Technology, Shinshu University,

Tokida 3-15-1, Ueda 386-8567, Japan.）


Highly plasticized poly(vinyl chloride) (PVC)-gels have brilliant performance as

electroactive gels. The plasticizers are commercially conventional ones with fairy low

specific dielectric constant (usually <10). The gels showed very small d3 strain as

expected, but huge “creeping deformation” to anode surface. The strain is only on

anode surface, but not on cathode surface. The gel exhibited colossal dielectric

constant (>103) at low frequency range less than kHz. The space charge distribution in

the gel shows totally asymmetric feature. On anode side, negative charge

accumulation is observed, but no positive charge on cathode side. The space charge

generated strong tacking force to anode and the repulsion among the charge leads the

expansion on anode, thus we can observe “amoeba-like” pseudopodial deformation of

the gel. This deformation can successfully be applied for “contractile artificial

muscle” which can pull up 80kg/10cm2 and durable over 5x106 times operation.

Furthermore, the gel exhibits electro-optical function such as Kerr effect over 30

times larger than that of nitrobenzene. Haptic sensor function will also be introduced

in the presentation.

Keywords: PVC, Gel, Dielectric, Electro-mechanical, Electro-optical,

Artificial-muscle, Piezo-function

References:

[1]. Wei Z.; Yang JH.; Liu ZQ.; Xu F.; Zhou JX.; Zrínyi M.; Osada Y.; Chen YM* ,

Adv. Funct. Mater. 2015, 25,1352 [1]. Hirai T.: Xia H: Chap.1, Handbook


11674263).



June 14-17, 2019

17

IL2-2

High Frequency dynamics of polymer solutions and gels studied by

microrheology

Tetsuharu Narita1,2

（1Laboratory of Soft Matter Science and Engineering, ESPCI Paris – CNRS – Sorbonne

Université, Paris, France; 2Global Station for Soft Matter, Global Institution for Collaborative

Research and Education, Hokkaido University, Sapporo, Japan）


The dynamics of soft matters spread across several orders of magnitude on the

time, reflecting the various relaxation processes at different length scales. For the case

of polymer solutions and gels, single chains and clusters of chains have specific

structures and corresponding dynamics, exhibiting characteristic scaling regimes of

viscoelastic moduli at a high frequency range (typically at 103 – 106 rad/s), while it is

not easy to access to these frequencies by conventional rotational shear rheometers.

We work on passive microrheology by dynamic light scattering techniques

(single dynamic light scattering, DLS, and multiple dynamic light scattering called

diffusing-wave spectroscopy, DWS) which allow us to access to the high frequency

range. From the dynamic light scattering signals coming from probe particles

dispersed in viscoelastic media, the mean square displacement of the particles due to

the thermal energy is measured. By using the generalized Stokes-Einstein relation one

can calculate high frequency viscoelastic moduli of the media. In this talk I will

briefly explain the experimental details of microrheology, then I will show some

examples of high frequency dynamics of polymer aqueous solutions and hydrogels:

(1) Single chain rigidity: Single chain rigidity can be characterized by its bending

mode found at high frequencies. By using solutions of a giant polysaccharide “sacran”

as model system, the bending mode was microrheologically studied. The

concentration dependence of the persistence length was discussed.

(2) Percolation of chains by transient crosslinks: A polymer network transiently

crosslinked by reversible associations flows at low frequency. Its gel point was

microrheologically determined by observing a high frequency power-law behavior

corresponding to the rheological response of a self-similar network at the percolation

point.

Keywords: microrheology, sol-gel transition, persistence length



June 14-17, 2019

18

IL4-1

Anisotropic composite gels from liquid crystalline nanosheets

Nobuyoshi Miyamoto‡‡

, Takumi Inadomi, Wenqi Yang

(Department of Life, Environment and Materials Chemistry, Graduate School of Engineering,

Fukuoka Institute of Technology, 3-30-1, Wajiro-Higashi, Higashi-ku, Fukuoka 811-0295, Japan)


Lyotropic liquid crystals (LCs) of inorganic nanosheets1) are emerging as

new-type LC materials with rich electric and optical functionalities inherent to

inorganic materials. Here we demonstrate the synthesis of composite hydrogels with

anisotropic properties by utilizing inorganic nanosheet LCs.2) The gels were

synthesized by photo-polymerization of N-isopropylacrylamide (NIPA) dissolved in

the liquid crystalline fluorohectorite clay colloid; electric field was applied during the

polymerization to achieve macroscopic alignment of the LC domains. The obtained

gels showed anisotropic properties such as optical birefringence and anisotropic

elastic moduli. The gels also show anisotropic molecular diffusion due to blocking of

diffusion by the aligned nanosheets. When self-oscillating BZ-reaction proceeds in

the gel, the patterns generated by the chemical wave propagation is concentric

ellipsoids, different form normal concentric circles, due to different diffusion rate of

the molecules along two axes. Further, the gel is printable with μm-scale resolution

with cationic dyes because the dye is strongly adsorbed electrostatically on the

anionic nanosheets. When the gel is irradiated with light, only the colored part is

photothermally deformed anisotropically, which is suitable for applications as soft

actuators.

Keywords: Inorganic nanosheets, Liquid crystal, Composite gel, Anisotropy

References:

[1] Miyamoto, N.; Nakato, T., Adv. Mater. 2002, 14 (18), 1267-1270.

[2] Miyamoto, N.; Shintate, M.; Ikeda, S.; Hoshida, Y.; Yamauchi, Y.; Motokawa, R.;

Annaka, M., Chem. Commun. 2013, 49, 1082-1084; Inadomi, T.; Ikeda, S.; Okumura,

Y.; Kikuchi, H.; Miyamoto, N., Macromol. Rapid Commun. 2014, 35, 1741-1746.

[4] Shintate, M.; Inadomi, T.; Yamamoto, S.; Kuboyama, Y.; Ohsedo, Y.; Arimura, T.;

Nakazumi, T.; Hara, Y.; Miyamoto, N., J. Phys. Chem. B 2018, 122, 2957–2961.

This research was supported by Strategic Research Foundation Grant-Aided Project for Private

University (#S1511036L) from MEXT and KAKENHI (#24104005 and #15K05657).



June 14-17, 2019

19

IL4-2

Biomimetic shape-transformation of composite hydrogel films

Zhihong Nie1§§, Teng Li2

（1State Key Laboratory of Molecular Engineering of Polymers,Department of Macromolecular

Science,Fudan University, 2005 Songhu Rd, Shanghai 200438, China; 2Department of Mechanical

Engineering,University of Maryland, College Park.）


Adaptable materials have been designed to respond to a particular, well-defined

external stimulus such as heat, light, or the variation in humidity, acidity and ionic

strength of the surrounding medium. Multiplexing system’s functionality is an

appealing concept that enables the design of materials with multiple, distinct

properties, each of which is activated by a particular external trigger[1]. In this talk, I

will present our efforts on achieving multiple 3D shape transformations of planar gel

sheets in response to distinct external triggers (e.g., pH, light, etc.)[2-6]. For instance,

we developed a composite macroporous hydrogel sheet that can rapidly transform into

multiple 3D shapes in response to near-infrared (NIR) light on demand. The

transformation relies on the photo-thermal-induced asymmetric shrinking of the

hydrogel material, which is further verified by finite element modeling.

Keywords: Hydrogel, Shapes, Deformation, Responsive, Films

References:

[1] Kempaiah, R.; Nie, Z. H. Journal of Materials Chemistry B 2014, 2, 2357-2368.

[2] Therien-Aubin, H.; Wu, Z. L.; Nie, Z. H.; Kumacheva, E. Journal of the American

Chemical Society 2013, 135, 4834-4839.

[3] Wu, Z. L.; Moshe, M.; Greener, J.; Therien-Aubin, H.; Nie, Z. H.; Sharon, E.;

Kumacheva, E. Nature Communications 2013, 4.

[4] Guo, H. Y.; Cheng, J.; Wang, J. Y.; Huang, P.; Liu, Y. J.; Jia, Z.; Chen, X. Y.;

Sui, K. Y.; Li, T.; Nie, Z. H. Journal of Materials Chemistry B 2017, 5, 2883-2887.

[5] Wei, Z. J.; Jia, Z.; Athas, J. M.; Wang, C. Y.; Raghavan, S. R.; Li, T.; Nie, Z. H.

Soft Matter 2014, 10, 8157-8162.

[6] Fan, W.X.; Shan, C.Y.; Guo, H.Y.; Sang, J.W.; Wang, R.; Zheng, R.R.; Tan,

Y.Q.; Sui, K.Y.; Nie, Z.H. Sci. Adv., 2019, 5(4), eaav7174.



June 14-17, 2019

20

IL 4-3

Active Gap Control of Gold Nanodots using Gels in Nanoscale

Hideyuki Mitomo1,2*, Satoshi Hamajima3, Kuniharu Ijiro1,2

（1 RIES, 2 GI-CoRE, 3Grad. Sch. of Chem. Sci. and Eng.,Hokkaido Univ., Sapporo 001-0021,

Japan）

*E-mail:[email protected]

Gold nanostructures are of considerable interest as their plasmonic phenomena

can provide functional applications. One of typical examples is a surface-enhanced

Raman scattering (SERS), which is a promising way for the label-free detections of

materials. On this SERS application, gap structures and their distances of metal

nanostructures are crucially important. A narrower gap can basically provide more

enhanced signals, but it also makes the insertion of analytes into the hot spots more

difficult owing to the steric hindrance. In our previous study, we had developed the

fabrication method for metal nanoarrays on the the hydrogel surface and investigated

whether active gap control by the gel volume change affected on SERS measurements

[1, 2]. As a results, we found this active gap control technique could provide further

enhanced SERS signals. However, it remains unclear how accurately controlled the

gap distance changes are. Therefore, in this study, we evaluated each gap distance on

the gels at various swelling conditions by scanning electron microscope observation.

Our results showed their gap changes are quite homogenous in nanometer scale,

although various ranges of inhomogeneities on the gel network were reported. Our

results suggested that active gap tuning using gels are quite useful [3].

Keywords: Gel, Gold nanostructures, Active Control, Surface Plasmon Resonance,

References:

[1] N. Shimamoto, Y. Tanaka, H. Mitomo, R. Kawamura, K. Ijiro, K. Sasaki, Y.

Osada*, Adv. Mater. 2012, 24, 5243.

[2] H. Mitomo, K. Horie, Y. Matsuo, K. Niikura, T. Tani, M. Naya, K. Ijiro*, Adv.

Opt. Mater., 2016, 4, 259.

[3] S. Hamajima, H. Mitomo*, T. Tani, Y. Matsuo, K. Niikura, M. Naya, K. Ijiro*,

Nanoscale Adv. 2019 (DOI: 10.1039/c8na00404h)

This research was supported by JSPS KAKENHI (Grant Number JP16K20870 and

JP18H01804).



June 14-17, 2019

21

IL 4-4

Anomalous expansion of clusters in percolation process in diluted

system

Takamasa Sakai1

（1Department of Bioengineering, Graduate School of Engineering, The Uniersity of Tokyo,

7-3-1 Hongo Bunkyo-ku, Tokyo, Japan）


Percolation is a process during which clusters grow and fill the system. In this paper,

we propose a new mechanism of percolation especially in a diluted system, which

predicts anomalous expansion of clusters during the agglomeration. We examined the

mechanism by investigating gelation processes of a diluted system by means of

experiments and molecular dynamics simulation. We confirmed that clusters grew

during the gelation, and a diluted system became a semi-diluted system just below the

gelation threshold. As a result, gels behaved as semi-diluted system regardless of the

initial polymer concentration. These results suggest the similarity between the

gelation threshold and the overlapping condition. This anomalous expansion is a key

of off-lattice percolation problem, and will help better understand general off-lattice

percolation problems.

Keywords: Gel, Sol-gel transition, Tetra-PEG gels

References:

[1] Fujinaga I.; Asai M.; Chung U.; Sakai T.*, submitted.

–––––––––––––––––––––––––––––––––

This research was supported by the JSPS (Grant No. 18H02027 and 16746899).



June 14-17, 2019

22

IL 5-1

Ion-to-Ion Amplification through an Open Junction 1 Ionic Diode

Jeong-Yun Sun

（Department of Materials Science & Engineering, Seoul National University, Seoul 08826,

Korea)

As biological signals are mainly based on ion transport, the differences in signal

carriers have become a major issue for the intimate communication between electrical

devices and biological areas. In this respect, an ionic device which can directly

interpret ionic signals from biological systems needs to be designed. Particularly, it is

also required to amplify the ionic signals for the effective signal processing since the

amount of ions acquired from biological systems is very small. In this study, we

report on the signal amplification in ionic systems as well as sensing through the

modified design of polyelectrolyte hydrogel based ionic diodes. By designing an open

junction structure, ionic signals from the external environment can be directly

transmitted to an ionic diode. Moreover, the minute ionic signals injected to the

devices and can also be amplified to a large amount of ions. The signal transduction

mechanism of the ion-to-ion amplification is suggested and clearly verified by

revealing the generation of breakdown ionic currents during an ion injection.

Subsequently, various methods for enhancing the amplification are suggested.



June 14-17, 2019

23

IL5-2

Active network of motor proteins as artificial dynamic

microenvironment for cells

Ryuzo Kawamura1,2***, Keisuke Meguriya1, Tsuyoshi Yokoyama1, Daiki Uehara1,

Naritaka Kobayashi2, Seiichiro Nakabayashi1,2, Hiroshi Y. Yoshikawa1,2

（1Depoartment of Chemistry, Saitama University, Saitama 338-8570, Japan; 2Division of

Strategic Research and Development, Graduate School of Science and Engineering, Saitama

University, Saitama 338-8570, Japan.）


Dynamic network of cytoskeletal and motor proteins generates various

movements and allows cells to divide, to deform and to migrate with consumption of

chemical energy. It means that in vivo micromechanical environment of cell is

mechanically dynamic due to the movement of the surrounding cells, as the cell in the

tissues are surrounded by the other cells. There, the nanometric movements of the

motor proteins are integrated to micrometer or larger scales with/without order and it

can lead to mechanical fluctuations at cellular scale in the environment. However,

conventional technique to culture cells on a plastic dish has lacked such a dynamic

micromechanics. Inspired from the dynamic property of the cells, we have been

proposing a dynamic substrate which can give mechanical stimulation to the culturing

cells in a mesoscopic scale from nano- to micrometer [1]. With use of microtubule

and kinesins [2], dynamic network of microtubules on a kinesin-coated glass surface

was constructed in a live cell compatible environment. Seeding cells on this dynamic

substrate coupled with ATP hydrolysis, we found that the mechanically stimulated

cells showed different morphology compared to those without stimulations.

Keywords: Gel, Active material, Motor protein, Cell Adhesion, Cancer

References:

[1]. Kawamura R*.; Uehara D.; Kobayashi N.; Nakabayashi S.; Yoshikawa H.Y.,

ACS Biomater. Sci. Eng. 2016, 2,2333.

[2]. Kawamura R*.; Sano K.; Osada Y., “Soft Actuators – Materials, Modelling,

Applications, and Future Perspectives (2nd edition, Springer). Edited by Kinji Asaka

and Hidenori Okuzaki”, Chapter “Employing Cytoskeletal Treadmilling in

Bio-Actuators” (in press).

This research was supported by LEADER program MEXT Japan, Nikki-Saneyoshi (JGC-S)

research grant and Takeda research grant.




June 14-17, 2019

24

IL5-3

Functional modification, Controllable Fabrication and Biomedical

Applications of natural polymer Hydrogel

Guang Yang*,, Lin Xiao, Lallepak Lamboni, Zhijun Shi

（Department of Biomedical Engineering, College of Life Science and Technology, Huazhong

University of Science and Technology, Wuhan 430074, PR China.）


Hydrogels prepared from natural polymers such as Bacterial cellulose (BC) and

Chitosan have been widely used in biomedical engineering, and functional electric

devices due to its outstanding properties in terms of super softness, surface porosity,

optical transparency, and biocompatibility. The objective of our project is to combine

the design and manufacture of nanomaterials with the functional modification,

nano\micro fabrication method to develop strategies to construct novel natural

polymer multifunctional hydrogel. In this research, we extended the application of

functional BC and Chitosan hydrogel in bioelectrical interface, biocompatible wound

healing materials, cell microcarriers, injectable drug delivery system, artificial

shape-memory blood vessels, hierarchical intervertebral disc and so on.

Keywords: bacterial cellulose, chitosan,

References:

[1] Yang J, Wang L, Zhang W, Sun Z, Li Y, Yang M, Zeng D, Peng B, Zheng W*,

Jiang X*, Yang G*. Small, 2018, 14(7), 1702582.

[2]Huang L, Xiao L, Poudel AJ, Li J, Zhou P, Gauthier M, Liu H*, Wu Z*, Yang G*.

Carbohydrate Polymers, 2018: 611-620.

[3]Li, Y., Tian, Y., Zheng, W., Feng, Y., Huang, R., Shao, J., Tang, R., Wang, P.,

Jia,Y., Zhang, J., Zheng, W., Yang, G., Jiang, X. Small, 2017, 13(27).

[4] Shi, Z., Gao, X., Ullah, M. W., Li, S., Wang, Q., Yang, G. Biomaterials, 2016,

40-54.



June 14-17, 2019

25

IL5-4

Ultrastretchable Stress and Strain Sensors Based on Tough

Conductive Hydrogels

Jun Fu1†††, Zhenwu Wang1, Liufang Wang1

（1Polymers and Composites Division, Ningbo Institute of Materials Technology and Engineering,

Chinese Academy of Sciences,Ningbo 315201, China.）


Ultrastretchable conductive materials are promisng for electronic skin,

human-machine interfaces, human activity monitors, and wearable electronic devices.

Currently, most strain sensors are comprised of elastomer matrix with metal

particles/liquid, carbon materials, or conductive polymers. In addition to the

stretchability and toughness, adhesive conductive hydrogels with linear sensitivity to

stress and strain are needed to fabricate reliable and wearable sensors to the skin.

This talk introduces, ultrastretchable and tough hydrogels with electronic or ionic

conductivities. Ionically conductive hydrogels comprised of zwitterionic chains

interpenetrating freeze-thawed PVA network show adhesiveness to many substrates

including glass, steel, polymer, and skin.

Electronic conductive hydrogels comprised of interpenetrating network of

polyalinine and P(AAm-co-HEMA) hydrogel show very high stretchability and

toughness. The hydrogels show a linear dependence on and high sensitivity to subtle

tensile strains (gauge factor 11).

The ultrastretchable and conductive hydrogels have been used to monitor subtle

movements of joints and wrist pusle, which suggest important applications in

implantable and wearable devices.

Keywords: Gel, Self-recovery, Conductivity, Sensor, Toughness, Stretchability

References:

[1]. Liufang Wang, Guorong Gao, Yang Zhou, Ting Xu, Jing Chen, Rong Wang, Rui

Zhang*, and Jun Fu*, ACS Applied Materials & Interfaces 2019, 11, 3506-3515.

[2]. Zhenwu Wang, Jing Chen, Yang Cong, Hua Zhang, Ting Xu, Lei Nie, Jun Fu*,

Chemistry of Materials 2018, 30, 8062-8069.


51873224).




June 14-17, 2019

26

IL5-5

Instabilities in soft materials: from gels to metamaterials

Jinxiong Zhou

State Key Laboratory for Strength and Vibration of Mechanical Structures, School of Aerospace,

Xi’an Jiaotong University, Xi’an 710049, China

Soft materials have low moduli, and are venerable to a variety of instabilities in

response to environmental stimuli. Understanding these instabilities are crucial for

design, control and fabrication of soft materials based devices and machines. In this

talk, I will summarize our recent efforts towards modeling and understanding of

instabilities in soft materials. The topics range from polymer gels, liquid crystal

elastomers and then the emerged soft mechanical metamaterials. Finally, conclusions

and perspectives regarding this topic are also given.



June 14-17, 2019

27

IL5-6

Stimuli-Responsive Smart Membranes

Liang-Yin Chu*

（School of Chemical Engineering, Sichuan University, Chengdu, Sichuan 610065, China.） *E-mail: [email protected]

Membranes are playing paramount roles for sustainable development in myriad

aspects such as energy, environments, resources and human health. However, the

unalterable pore size and surface property of traditional porous membranes restrict

their efficient applications. The performances of traditional membranes will be

weakened upon the unavoidable membrane fouling, and they cannot be applied to the

cases where self-regulated permeability and selectivity are required. Inspired by the

natural cell membranes with stimuli-responsive channels, artificial stimuli-responsive

smart membranes are developed by chemically/physically incorporating

stimuli-responsive materials as functional gates into traditional porous membranes to

provide advanced functions and enhanced performances for breaking the bottlenecks

of traditional membrane technology. The smart membranes, integrating the

advantages of traditional porous membrane substrates and smart functional gates, can

self-regulate their permeability and selectivity via flexible adjustment of pore sizes

and surface properties based on the "open/close" switch of the smart gates in response

to environmental stimuli.[1-3] This presentation introduces the recent development of

stimuli-responsive smart membranes, including the design strategies and the

fabrication strategies that based on introduction of the stimuli-responsive gates after

or during membrane formation, the positively and negatively responsive gating

models of versatile stimuli-responsive smart membranes, as well as the advanced

applications of smart membranes for regulating substance concentration in reactors,

controlling release rate of drugs, separating actives based on size or affinity, and

self-cleaning of membrane surfaces. With self-regulated membrane performances,

the smart membranes show great power for global sustainable development.

References:

[1] L.Y. Chu, Smart Membrane Materials and Systems, Springer-Verlag, Berlin (2011).

[2] Z. Liu, W. Wang, R. Xie, X.J. Ju, L.Y. Chu, Chem. Soc. Rev., 45, 460-475 (2016).

[3] L.Y. Chu, Smart Membranes, Royal Society of Chemistry, UK (2019).




June 14-17, 2019

28

IL5-7

Construction of molecular swarm robot integrating

biomolecular soft actuators and processors

Akira Kakugo1,2‡‡‡, Jakia Jannat Keya1, Akinori Kuzuya3

（1Faculty of Science, Hokkaido University, Sapporo 060-0810, Japan; 2Graduate School of

Chemical Sciences and Engineering, Hokkaido University, Sapporo 060-0810, Japan; 3Department

of Chemistry and Materials Engineering, Kansai University, Osaka 564-8680, Japan）


In nature swarming behavior evolves repeatedly among motile organisms

offering a variety of beneficial emergent properties. Switching between solitary and

swarm behavior can include improved information gathering, protection from

predators, and resource utilization. Inspired by the aspects of swarming behavior,

attempts have been made to construct swarm robots from motile supramolecular

systems composed of biomolecular motor system where cross-linkers induce large

scale organization. Here, we demonstrate that the swarming of DNA-functionalized

microtubules (MTs) propelled by surface-adhered kinesin motors can be programmed

and reversibly regulated by DNA signals. Emergent swarm behavior, such as

translational and circular motion, can be selected by tuning the MT stiffness.

Photoresponsive DNA containing azobenzene groups enables switching of swarm

behavior in response to stimulation with visible or ultraviolet light. Such control of

swarming offers design and development of molecular swarm robots based on natural

molecular devices.

Keywords: Swarming, Biomolecular motors system, DNA, swarm robot.

References:

[1]. Keya JJ.; Suzuki R.; Kabir AMR.; Inoue D.; Asanuma H.; Kazuki S.; Hess H.;

Kuzuya A.,* Kakugo A* Nat. Commun. 2018, 9:453

[2]. Keya JJ.; Kabir AMR.; Inoue D.; Kazuki S.; Hess H.; Kuzuya A.,* Kakugo A*

Sci. Rep. 2018, 8:11756

This research was supported by the Grant-in-Aid for Scientific Research on Innovative Areas

“Molecular Robots” (JSPS KAKENHI Grant Number JP24104004).



June 14-17, 2019

29

IL5-8

Polysaccharide-based ionic hydrogel

Kun Yan Sui§§§

, Xiao Hui Zhang, Nan Nan Sheng, Hui Lin Cui, Na Pan

（State Key Laboratory of Bio-fibers and Eco-textiles, College of Materials Science and Engineering, Shandong Collaborative

Innovation Center of Marine Biobased Fibers and Ecological Textiles, Institute of Marine Biobased Materials, Qingdao University,

Qingdao 266071, China.）


Polysaccharides have become an ideal material for the preparation of

high-performance hydrogels due to their reproducibility, biocompatibility and

biodegradability. The prepared hydrogel has been widely used in soft robots, flexible

electronic devices, sensors, and biomedicine. Recently, we have fabricated a new

skin-inspired ionic hydrogel sensor composed of supramolecular SA nanofibrils by

salting-out of NaCl and chemically crosslinked PAM. The hydrogels exhibited

excellent mechanical properties and sensitive properties which could immediately and

stably monitor human motion from large movement (limbs) to small deformation

(pronunciation, pulse). In addition, we have described an extremely simple and

ultra-fast procedure (10 s-30 min) for one-step synthesis of the gradient

all-polysaccharide polyelectrolyte complex hydrogel film using diffusion-driven

interfacial reaction. The all-polysaccharide actuators can address the challenge of

simultaneously improving the mechanical properties (2.26 MPa), response kinetics (2

s) and programmable locomotion capability for practical applications. This new

synthesis strategy provides guidance for fabricating biodegradable and biocompatible

hydrogel actuators with applications in tissue engineering, soft robotics and active

implants.

Keywords: Polysaccharides, Polyelectrolyte, Hydrogel, Sensor, Actuators

References:

[1] X. H. Zhang, N. N. Sheng, L. N. Wang, Y. Q. Tan, C. Z. Liu, Y. Z. Xia, Z. H.

Nie*, K. Y. Sui*. Mater. Horiz. 2019, 6, 326-333.

[2] H. L. Cui, N. Pan, W. X. Fan*, C. Z. Liu, Y. H. Li, Y. Z. Xia, K. Y. Sui*. Adv.

Funct. Mater. 2019, 1807692.


51573080 and 51873094).



June 14-17, 2019

30

OL 1-1

Super-elastic and multifunctional polymer hydrogel strengthened by

low-content cement-released nanoparticles

Guo Xing Sun1,2****, Rui Liang1, Xiao Sai Hu1, Xiao Xu Liang1, Hong Yao Ding1

（1 Joint Key Laboratory of the Ministry of Education, Institute of Applied Physics and Materials

Engineering, University of Macau, Avenida da Universidade, Taipa, Macau SAR, China. 2 Department of Physics and Chemistry, Faculty of Science and Technology, University of Macau,

Avenida da Universidade, Taipa, Macau SAR, China.）


Portland cements are innovatively used to obtain sub-5 nm particles. Such novel

cement-released nanoparticles pioneer super-elastic and multifunctional polymer

hydrogel, and drying-resistance oil gel. The calcium hydroxide nano-spherulites (CNS)

with diameters < 5 nm release from the surface of cement particles when cement

particles are dispersed in water at 0℃. A very low content of CNS can remarkably

strengthen and tough polymer hydrogels due to the small size effect of CNS. The

poly(acrylamide) (PAM)/ CNS hydrogel cross-linked by 40 ppm CNS can be

stretched to more than 100 times strain with a stress of more than 500 KPa. The poly

(acrylic acid) (PAA)/CNS super-adsorbent hydrogel enhanced by 200 ppm CNS

shows excellent adsorption capacity for the removal of methylene blue dye (2,100

mg/g). Furthermore, conductive polymer/CNS hydrogel possesses high electrical

conductivity (20,830 S/m) and can be stretched up to 1,076% strain, showing

potential application in flexible stretchable electronic devices. PAM/ CNS hydrogel

also exhibits excellent cell adhesion property, which is expected to become artificial

biological tissues with super-enhanced mechanical properties.

Keywords: Gel, Calcium hydroxide nano-spherulites, Super-elastic, Multifunctional

References:

[1]. Sun GX.; Li ZJ*; Liang R.; Weng LT.; Zhang LN, Nat. Commun. 2016, 7, 12095.

[2]. Hu XS.; Liang, R.; Sun GX*, J Mater Chem A. 2018, 36, 17612.

This research was supported by Science and Technology Development Fund from Macau

(FDCT-078/2017/A2).




June 14-17, 2019

31

OL 1-2

OSA-AM hydrogel with high-strength and faster self-healing

property from sodium alginatei

Ya Ping Li, Hu Wei Xin, Ling Bin Lu*

(School of Materials Science and Engineering, Hainan University, Haikou, 570228, China)


With the capability of being repaired by themselves after mechanical damage,

traditional self-healing hydrogels are fragile or have unsatisfactory recovery

capability, which limit their applications. Currently, enhanced mechanical properties

and healing time of self-healing hydrogels are focused on. In this work, as a raw

material, sodium alginate was oxidized in order to introduce aldehyde groups. Then

the oxidized sodium alginate (OSA) and acrylamide (AM) interacted. Finally, the

OSA-AM hydrogel was formed via the chemical crosslink between aldehyde groups

and amide groups. The dynamic Schiff base between OSA and AM enabled the

OSA-AM hydrogel to sense the defect and to heal up without external interaction.

Further, hydrogen bonds between these two compounds enhanced the capability.

Shorter healing time (less than 1h) was achieved. At the same time, the hydrogel

possessed high fracture strength. Hence, the OSA-AM hydrogel has potential

promising application in the field of smart biomedical materials, such as artificial

skins.

Keywords: Hydrogel, Alginate, Acrylamide, Self-healing, Schiff base

References:

[1]. Liu SL.; Kang MM.; Li KW.; Yao F.; Oderinde O.; Fu GD*.; Xu LQ*, Chemical

Engineering Journal. 2018, 334, 2222

[2]. Jing X.; Mi HY.; Napiwocki B.; Peng XF*, Carbon. 2017, 125, 557

[3]. Sun CY.; Jia HY.; Lei K.; Zhu DD.; Gao YH.; Zheng Z.; Wang XL*, Polymer.

2019, 160, 246

[4]. Cai TT.; Huo SJ,; Sun WX.; Wang T*; Tong Z**, Carbohydrate Polymers. 2018,

193, 54

This work was supported by the Key Research and Development Program of Hainan

Province (No.ZDYF2018016), and the Project supported by the Education

Department of Hainan Province (No.Hnky2019ZD-5).




June 14-17, 2019

32

OL 1-3

High Strength Globular Protein Hydrogels

Qiang Chen1,††††, Ziqing Tang1, Zhao Liu1, Lin Zhu

（1School of Materials Science and Engineering, Henan Polytechnic University, Jiaozuo 454000,

China.）


Developing functional hybrids of globular proteins and synthetic polymers into

multipurpose tough hydrogels remain to be challenging. Here, we propose a new

strategy combining double network and protein misfolding concepts to create diverse

protein/polymer double-network (DN) hydrogels with both high bulk and interfacial

toughness. The method integrates an intrinsic heat-induced protein

denaturation/aggregation feature and a double-network concept that produce different

bovine serum albumin (BSA)-based DN hydrogels with hybrid physical-chemical

crosslinking or fully physical crosslinking to achieve high modulus of 252-1199 kPa,

high strength of 0.24-0.48 MPa, high fracture energy of 3.56-16.88 MJ/m3, high

extensibility of 7.7-79.9 mm/mm, fast self-recovery (stiffness/toughness recovery of

94%/80% after heat treatment at 80 oC for 30 min), and strong surface adhesion to

various nonporous solid surfaces (interfacial toughness of 1176-2827 J/m2). Such

tough and adhesive protein/polymer hydrogels have great potentials for different

applications of artificial soft tissues, flexible electronics, and wearable devices.

Keywords: Double-Network Hydrogels, Globular Protein, High Strength,

Self-Recovery, Tough Adhesion

References:

[1]. Tang ZQ.; Chen Q*.; Chen F.; Zhu L.; Lu SP.; Ren BP.; Zhang YX.; Yang J.;

Zheng J* , Chem. Mater. 2019, 31,179


21504022 and U1304516).



June 14-17, 2019

33

OL 1-4

Multiple Functions of High Performance Hydrogels Enhancement by

Hydrogen Bond

Xuefeng Li, Xueyin Peng, Rongzhe Li

（Hubei Provincial Key Laboratory of Green Materials for Light Industry, School of Materials

Science and Engineering, Hubei University of Technology, Wuhan 430068, P. R. China.）

*E-mail: [email protected].

A new class of polymer hydrogels with H-bonding and metal-coordination dual

physically crosslinked networks is successfully designed. The nature of physical

crosslinks makes the hydrogel network self-recoverable, and enables dissipation of

mechanical load through energy-dissipating sacrificial linkages mechanisms.[1-2]

In this study, we chose a functional monomer 2-Vinyl-4,6-diamino-1,3,5-triazine

(VDT), whose Diaminotriazine (DAT) moieties are capable of forming strong and

stable H-bonding in water. copolymerization of VDT, acrylic acid (Ac) and

acrylamide (Am) to form a preformed gel (P-gel). Then, soaking the P-gel in Fe3+

aqueous solution to form carboxylic-Fe3+ coordination to obtain S-hydrogel which has

a good potentials for stable and strong physical interaction. Afterwards, a dual

physically cross-linked hydrogel (D-hydrogel) was finally prepared by soaking the

S-hydrogel in deionized water to remove free Fe3+ that probably enabled final

stabilization of both the H-bonds and the ionic coordination. As a result, D-hydrogel

with excellent mechanical properties and self-recoverable properties. Figure 1 depicts

formation of the dual physical crosslinks.

Figure 1. Schematic diagram of the formation of a D-hydrogel with dual physical crosslinking.

In order to study potentials of the D-hydrogel for physical adsorption in aqueous

phase. We have synthesized PVDT nanoparticles which has a capacity of quick

adsorption of uric acid in pH 7.4 phosphate buffered saline. The mechanism for the

adsorption was ascribed to simultaneous formation of three H-bonds between the

DAT moieties and each of the target molecules (Figure 2(a)). The 5-Fu was chosen as

a guest molecule and the D-hydrogels fabricated with different VDT contents were

used to investigate the correlation between the DAT content in the copolymers and



June 14-17, 2019

34

their adsorption capacities. Figure 2(b) shows a clear downward trend in absorbance

at 292 nm as the VDT content gradually increased in the copolymer. Finally, the

quantity of 5-Fu adsorbed by each gram of the copolymer was calculated and shown

in Figure 2(c).

Figure 2. H-bonding between DAT group and 5-Fu molecule (a). Absorbance of 292 nm

corresponds to the change of 5-Fu concentration (b). Capacity of 5-Fu adsorption with varied VDT

content in the D-hydrogels (c).

As we known, capacitive sensor can be applied to detect human motion and

complicate muscle movements as ionic skin sensor. We soaked the D-hydrogel in

lithium chloride solution to allow the D-hydrogel absorb conductive Li+. As shown in

Figure 3(a), we constructed a capacitive pressure sensor by integrating two hydrogel

films with a dielectric layer (polyethylene terephthalate film). The D-hydrogel-Li+

was the conductive layer, in which Fe3+ and freely moving Li+ provide good

conductivity. Figure 3(b) shows the sensor is attached to the finger. When the finger is

bent, the capacitance undergoes a stable and repeatabie change.

Figure 3. Schematic design of the D-hydrogel-Li+ capacitive sensor as ionic skin (a). Real-time

capacitance signals when the finger bends cyclically and photos of hydrogel sensors attached to a

bent or straight finger (b).

Therefore, Dual physical crosslinks of H-bonding and ionic coordination

significantly enhanced the hydrogel mechanical properties. Incorporation of VDT

units into the copolymer chains endued the hydrogel with capacity of physical

adsorption of antitumor 5-Fu, and ionic coordination provided good conductivity after

absorbing Li+. These applications show that D-hydrogel-Li+ based ionic skin has great

potential as a highly sensitive pressure and strain sensor for AI and wearable devices.

Keywords: High strength hydrogel; Diaminotriazine; Integrated Functional;

Synergistic effect.

References:



June 14-17, 2019

35

[1]. J. P. Gong, Y. Katsuyama, T. Kurokawa, Adv. Mater. 2003, 15, 1155.

[2]. D. D. Lane, S. Kaur, G. M. Weerasakare, Soft. Matter. 2015, 11, 6981.



June 14-17, 2019

36

OL 1-5

Predictions of Thermo‐Mechanical Properties of Cross‐Linked

Polyacrylamide Hydrogels Using Molecular Simulations

Meng An1,3,*, Baris Demir2, Xiao Wan3, Han Meng3, Nuo Yang3, and Tiffany R.

Walsh2

（ 1College of Mechanical and Electrical Engineering, Shaanxi University of Science and

Technology, 6 Xuefuzhong Road, Weiyangdaxueyuan, Xi’an 710021, P.R. China. 2Institute for

Frontier Materials, Deakin Unviersity, Geelong, VIC 3216, Austrailia. 3Nano Interface Center for

Energy, School of Energy and Power Engineering, Huazhong University of Science and

Technology, Wuhan, 430074, P.R. China）


Hydrophilic acrylamide‐based hydrogels are emerging platforms for numerous

applications, but the resources to fully exploit these materials are currently limited. A

deep understanding of the molecular‐ level structure/property relationships in

hydrogels is crucial to progressing these efforts. Such relationships can be challenging

to elucidate on the basis of experimental data alone. Here, molecular simulations are

used as a complementary strategy to reveal the molecular‐level phenomena that

govern the thermo‐mechanical properties of hydrogels. The focus is on acrylamide

‐based hydrogels cross‐linked with N,N′‐methylenebisacrylamide, generated

using previously established computational cross‐linking procedure. The water

content is found to be a key determinant in the elastic response of these hydrogels,

with enhanced tensile and shear properties at low water content. However, it is also

found that increasing water content enhances the hydrogel's thermal conductivity,

with the dominant contribution arising from the non‐bonded contributions to the

heat flux. In addition, chemical cross‐linking improves the heat transfer properties

of the hydrogel, whereas a reduction in convective heat transfer is predicted with an

increase in hydrogel cross‐linking. These simulations provide a rational basis for

designing and testing customized hydrogel formulations for maximizing both thermal

conductivity and mechanical properties.

Keywords: Cross-linking, Hydrogels, Molecular dynamics simulations,

Polyacrylamides, Thermal conductivity



June 14-17, 2019

37

References:

[1]. Meng A., Baris D.; Xiao W., Han M.; Nuo Y.; Tiffany R., Adv. Theor.

Wei Z.; Yang JH.; Liu ZQ.; Xu F.; Zhou JX.; Zrínyi M.; Osada Y.; Chen YM* ,

Adv. Theory Simul. 2019, 2,1800153.



June 14-17, 2019

38

OL 1-6

Solvent responsive ultra-strong shape memory gels based on

hydrophobic association with fantasy applications

Tao Wang1‡‡‡‡, Jiexin Liao1, Jiahe Huang1, Shurui Yang1, Weixiang Sun1, Zhen Tong1,

2*

(1Research Institute of Materials Science and 2State Key Laboratory of Luminescent Materials and

Devices, South China University of Technology, Guangzhou 510640, China.)

*E-mail: [email protected] (T. Wang), [email protected] (Z. Tong)

Introduction of hydrophobic association through copolymerization in water or in

organic solvents followed by solvent exchange provided an effective and facile

approach to reinforce gels and realize shape memory or other capabilities. However,

fast response rate and multifunctional applications still need to be explored to broaden

the applications in soft actuator and biomedical fields. Novel ultra-strong hydrogels

with rapid solvent responsive shape memory behavior were prepared through the

association of monomers with hydrophobic side groups such as dopamine

methacrylamide and butyl methacrylate. The gels were synthesized in water and

DMSO mixed solvent, while the ultra-strong hydrogels with strength up to 9 MPa and

modulus of 200 MPa were obtained through solvent in water. At the same time, the

formation and dissociation of the hydrophobic association showed excellent

reversibility, which endowed the gels with solvent induced shape memory and

actuating capabilities. In addition, solvent leakage warning system, sustainable and

erasable “gel paper”, bioinspired bilayer flower and other soft actuators were designed

to explore the fantasy applications of these multifunctional strong gels.

Keywords: Ultra-strong gels, Shape memory, Hydrophobic association, Actuator

This research was supported by the NSFC (51573060 and 21427805) and the Pearl River S&T

Nova Program of Guangzhou (201710010146).



June 14-17, 2019

39

OL 1-7

Electroactive Hydrogels: synthesis, characterization and application

Zhijun Shi1,, Li Wang1, Sanming Hu1, Guang Yang1*

（1 Department of Biomedical Engineering, College of Life Science and Technology, Huazhong

University of Science and Technology, Wuhan 430074, PR China.）


Hydrogels prepared from natural polymers have received immense

considerations over the past decade due to their safe nature, biocompatibility,

hydrophilic properties, and biodegradable nature. More recently, when treated with

electroactive materials, these hydrogels were endowed with high electrical

conductivity, electrochemical redox properties, and electromechanical properties;

consequently, forming an electroactive hydrogel. These hydrogels are good candidate

materials for use in biomedical devices, such as biosensors, electro-stimulated drug

release devices, bioactuators, nanogenerators, and implanted electrodes. To further

explore the applications of electroactive hydrogel in biomedical field, one promising

strategy is to make electroactive hydrogel with similar ordered structure with natural

tissue or organ, or guide the cell alignment to form ordered multicellular structures,

and finally, make the artificial tissues or organs perform their functions. In this work,

we fabricated electroactive hydrogel with ordered 2D/3D microstructure. On the basis

of culture protocol on these materials involving the systematic delivery of intermittent

electric field stimulation, both the microstructured substrate and electric field strength

will be established to promote cellular activities such as cell division, migration,

differentiation and designificant morphological extensions. And then we will examine

the mechanisms of the cellular activities under the impact of the two cues to study

further about the enhancement of interaction of contact guidance with electric field in

guiding cells, which will be fundamental in skin/cornea wound healing, nerve orderly

regeneration, vascular tissue engineering, etc.

Keywords: bacterial cellulose, electroactive hydrogel, ordered 2D/3D microstructure,

electric stimulation

References:

[1] Shi, Z., Shi, X., Ullah, M.W. et al. Adv Compos Hybrid Mater, 2018, 1: 79.

[2] Shi, Z., Gao, X., Ullah, M. W., Li, S., Wang, Q., & Yang, G. Biomaterials, 2016,

40-54.



June 14-17, 2019

40

OL 1-8

Highly-tough single-network polysaccharide hydrogel

Chaoxi Wu1§§§§, Yifei Wang

（1†Guangzhou Jinan Biomedicine Research and Development Center, Institute of Biomedicine,

College of Life Science and Technology, and ‡Biomedical Engineering Institute, Jinan University,

Guangzhou 510632, China.）


Polysaccharides are biocompatible and biorenewable polymers which are very

frequently used in the formation of hydrogels. However, most polysaccharide

hydrogels are fragile with low stretchability, which largely limit their applications.

Currently no polysaccharide hydrogel can stretch to over 1.5 times of its original

length without break. Here a novel polysaccharide hydrogel with extremely high

stretchability are reported in this work. This hydrogel can stretch to >2.5 times of its

original length and exhibit a tensile strength of >1 MPa. This polysaccharide hydrogel

is solely based on beta-glucan, which is known to form very stiff triple helix. The new

method have successfully triggered the beta-glucan molecules to pack into triple

helices and then into nanofiber network. This hydrogel have high crystallinity and

advanced network structure, which is utterly different from previous beta-glucan

hydrogel. This highly stretchable beta-glucan hydrogel may be used in tissue

engineering and wound dressing due to its good mechanical properties.

This research was supported by Pearl River S&T Nova Program of Guangzhou (706065366041)




June 14-17, 2019

41

Keywords: Single network, polysaccharide, highly tough, hydrogel

References:

[1]. Self-Assembly of Core Corona beta-Glucan into Stiff and Metalizable Nanostructures from 1D

to 3D 作者: Wu, Chaoxi; Wang, Xiaoying; Chu, Bin; 等.

ACS NANO 卷: 12 期: 10 页: 10545-10553 出版年: OCT 2018

http://apps.webofknowledge.com/full_record.do?product=UA&search_mode=GeneralSearch&qid=5&SID=7F7yPRBYOmwBedbePUI&page=1&doc=1

http://apps.webofknowledge.com/full_record.do?product=UA&search_mode=GeneralSearch&qid=5&SID=7F7yPRBYOmwBedbePUI&page=1&doc=1

http://apps.webofknowledge.com/OneClickSearch.do?product=UA&search_mode=OneClickSearch&excludeEventConfig=ExcludeIfFromFullRecPage&SID=7F7yPRBYOmwBedbePUI&field=AU&value=Wu,%20Chaoxi

http://apps.webofknowledge.com/OneClickSearch.do?product=UA&search_mode=OneClickSearch&excludeEventConfig=ExcludeIfFromFullRecPage&SID=7F7yPRBYOmwBedbePUI&field=AU&value=Wang,%20Xiaoying

http://apps.webofknowledge.com/OneClickSearch.do?product=UA&search_mode=OneClickSearch&excludeEventConfig=ExcludeIfFromFullRecPage&SID=7F7yPRBYOmwBedbePUI&field=AU&value=Chu,%20Bin



June 14-17, 2019

42

OL 1-9

Molecular engineering of metal-coordination interactions for strong,

tough and fast-recovery hydrogels

Wenxu Sun1, Bin Xue1, Yi Cao1*****

（1 Collaborative Innovation Center of Advanced Microstructures, National Laboratory of Solid

State Microstructure, and Department of Physics, Nanjing University, Nanjing 210093, China.）


Many load-bearing tissues, such as muscles and cartilages, show high elasticity,

toughness and fast recovery. However, combining these mechanical properties in the

same synthetic biomaterials (i.e. hydrogels) is fundamentally challenging as they

require contradictive mechanical and dynamical properties of the cross-linkers. For

example, hydrogels cross-linked by stable bonds are strong but recover slowly and

hydrogels cross-linked by dynamic bonds recover quickly but are mechanically weak.

Here, we show that strong, tough and fast-recovery hydrogels can be engineered using

cross-linkers involving cooperative dynamic interactions. We designed a

histidine-rich decapeptide containing tandem repeats of two zinc binding motifs. This

decapeptide had a stronger binding strength, higher thermodynamic stability, and

faster binding rate than single binding motif or isolated ligands (histidine). The

engineered double-network hydrogels containing the peptide-metal complex exhibit a

high elasticity of ~300 kPa, ultratoughness of ~1,500 kJ m-3 and fast recovery in

seconds under multiple load-unload cycles, comparable to mechanical properties of

articular cartilage. We expect that they can function effectively as scaffolds for

load-bearing tissue engineering and as building blocks for soft robotics. Our results

provide a general route to tune the mechanical and dynamic properties of hydrogels at

the molecular level.

Keywords: Gel, Fast-recovery, Metal chelation, Cooperativity, Toughness

This research was supported by the National Natural Science Foundation of China (Grant No. No.

21522402, 11674153, 81622033, 21774057 and 11804148).




June 14-17, 2019

43

OL 1-10

Injectable Hydrogel Formed by Metal–Ligand Coordination

Assembly as Biomaterials

Liyang Shi†††††

（State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, Hunan

University, Changsha 410082, China.）


Hydrogels are 3D polymeric cross-linked networks that retain substantial amounts

of water that are promising biomaterials in the fields of tissue engineering, drug

delivery, and biosensing etc. Particularly, the presented hydrogels based on

metal-ligand coordination chemistry provide new and exciting properties that improve

injectability, rheological behaviors, and even biological functionalities.[1] In my works,

several injectable hydrogels crosslinked by bisphosphonate (BP) and metal ions or

metallic nanoparticles were fabricated, which showed self-healing and shear-thinning

because of the inherent reversibility of BP-metal coordination bonds. [2-5] To prepare

the meal-BP based hydrogel, we firstly conjugated the BP groups on the backbones of

hyaluronic acid (HA) followed by introducing the metal sources into the BP modified

HA (HA-BP) solution. Specifically, two types of metal ions (i.e., Ca2+ and Ag+ ions)

as well as two types of metal salts particles (i.e., calcium phosphate coated silk

microfibers (CaP@mSF) and magnesium silicate (MgSiO3) nanoparticles) were used

to generate the hydrogels. Additionally, the hydrogels can form a secondary

cross-linkage with covalent bonds under UV curing. The presented four types of

HA-BP based hydrogels were applied in several biomedical applications such as 3D

printing, wound healing, bone regeneration, and controlled anticancer drug delivery.

Compared with the non-dynamic bonds forming injectable hydrogels based on

cross-linking of liquid polymer precursors during or after injection, my meal-BP

based hydrogels exhibited unlimited time window for injection.

Keywords: Bisphosphonate, Biomaterials, Coordination Chemistry, Injectable

Hydrogels

References:

[1] Shi, L.; Ding, P.; Wang, Y.; Zhang, Y.; Ossipov, D.; Hilborn, J., Self-Healing

Polymeric Hydrogel Formed by Metal-Ligand Coordination Assembly: Design,

Fabrication, and Biomedical Applications. Macromol. Rapid Commun. 2019,

This research was financially supported by the Fundamental Research Funds for the Central

Universities (No. 531107051242).




June 14-17, 2019

44

e1800837.

[2] Shi, L.; Carstensen, H.; Hölzl, K.; Lunzer, M.; Li, H.; Hilborn, J.; Ovsianikov, A.;

Ossipov, D. A., Dynamic Coordination Chemistry Enables Free Directional Printing

of Biopolymer Hydrogel. Chem. Mater. 2017, 29 , 5816-5823.

[3] Shi, L.; Wang, F.; Zhu, W.; Xu, Z.; Fuchs, S.; Hilborn, J.; Zhu, L.; Ma, Q.; Wang,

Y.; Weng, X.; Ossipov, D. A., Self-Healing Silk Fibroin-Based Hydrogel for Bone

Regeneration: Dynamic Metal-Ligand Self-Assembly Approach. Adv. Funct. Mater.

2017, 27,1700591.

[4] Shi L., Zhao Y., Xie Q., Fan C., Hilborn J., Dai J., Ossipov D. Moldable

hyaluronan hydrogel enabled by dynamic metal-bisphosphonate coordination

chemistry for wound healing, Adv. Healthc. Mater. , 2018, 7，1700973.

[5] Shi, L.; Han, Y.; Hilborn, J.; Ossipov, D., "Smart" drug loaded nanoparticle

delivery from a self-healing hydrogel enabled by dynamic magnesium-biopolymer

chemistry. Chem. Commun. 2016, 52 , 11151-11154.



June 14-17, 2019

45

OL 1-11

Fabrication of chitosan functionalized graphene oxide-embedded

nanocomposite hydrogels with enhanced mechanical properties

Sijun Liu‡‡‡‡‡

（Advanced Rheological Institute, Department of Polymer Science and Engineering,

Shanghai Jiao Tong University, Shanghai 200240, P. R. China.）


Chitosan hydrogel formed by the traditional acidic dissolved method usually

exhibits poor mechanical property. To break this limitation, the alkali/urea solvent

system was created to dissolve chitosan via the freezing−thawing process, and then a

bended chitosan physical hydrogel was prepared after immersing hot water to remove

alkali and urea. In this study, we fabricated an enhanced chitosan nanocomposite

hydrogel based on the alkali/urea aqueous solvent. Frist of all, the covalent

functionalization of graphene oxide (GO) with chitosan (CS) was successfully

accomplished via a facile amidation process. Secondly, the chitosan nanocomposite

hydrogel (Chi-CGO) was constructed by combing chitosan-grafted graphene oxide

(CGO). The experimental results indicated that the presence of CGO greatly enhanced

the mechanical property of chitosan hydrogel, for example, the elastic modulus and

strain at break of Chi-CGO0.5 respectively increased by 3.2 and 1.8 times in contrast

to the pure Chi. Most importantly, the resulted Chi-CGO hydrogel demonstrates an

excellent biocompatibility. This novel strategy greatly enriches the construction of

chitosan hydrogels with good mechanical properties and expands its application in the

area of tissue engineering.

Keywords: Chitosan, nanocomposite hydrogel, graphene oxide

References:

[1]. H. Bao, Y. Pan, Y. Ping, N. G. Sahoo, T. Wu, L. Li,* J. Li, and L. H. Gan, Small,

2011, 7, 1569.

[2]. J. Duan, X. Liang, Y. Cao, S. Wang, and L. Zhang*. Macromolecules, 2015, 48,

2706.




June 14-17, 2019

46

OL 1-12

Freezing-Tolerant Gelatin Organohydrogels with High Mechanical

Performances, Thermoplasticity, and Adhesivity

Zhi Hui Qin1, Fang Lian Yao1,2,3*, Jie Jun Li1,3*

（1 School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, China; 2

School of Materials Science and Engineering, East China Jiaotong University, Nanchang 330013,

China;3 Key Laboratory of Systems Bioengineering of Ministry of Education, Tianjin University,

Tianjin 300350, China.）


[email protected]

Relative low mechanical strength and the deterioration of desirable performances at

subzero temperatures are the two main deficiencies facing natural polymer-based

hydrogels, which severely limits their applications. Here, we report a high-mechanical

and anti-freezing protein-based organohydrogel by applying a simple strategy of

immersing a virgin gelatin hydrogel into citrate (Cit) water-glycerol mixture solution.

In the organohydrogel, a part of water molecules are replaced by glycerol, which

inhibits the formation of ice crystallization even at extremely low temperature. The

formation of hydrophobic aggregation induced by the salting-out effect, ionic

interaction between the –NH3+ of gelatin chains and Cit3− anions, as well as hydrogen

bond between gelatin chains and glycerol during the immersing procedure endows the

organohydrogels with high strength and toughness. The organohydrogel can maintain

their mechanical flexibility even at -80 °C. Moreover, owing to reversible nature of

physically crosslinked domains, the organohydrogels display intriguing remoldability,

good healing ability and excellent adhesive behavior at various substrates.

Keywords: organohydrogel, anti-freezing, high strength, remoldability, non-covalent

interactions

References:

[1]. Rong, Q.; Lei, W.; Chen, L.; Yin, Y.; Zhou, J.; Liu, M. Anti-freezing, Conductive

Self-Healing Organohydrogels with Stable Strain-Sensitivity at Subzero Temperatures.

Angew. Chem., Int. Ed. 2017, 56, 14159-14163.

[2]. Morelle, X. P.; Illeperuma, W. R.; Tian, K.; Bai, R.; Suo, Z.; Vlassak, J. J. Highly

Stretchable and Tough Hydrogels below Water Freezing Temperature. Adv. Mater.

2018, 30, 1801541.



June 14-17, 2019

47

Acknowledgments

This work is supported by The Excellent Young Scientists Fund by National

Natural Science Foundation of China (No. 31722022), National Nature Science

Foundation of China (No. 51573127, 51733006, 31870948) and National Key

Research and Development Program of China (No. 2018YFC1105502).



June 14-17, 2019

48

OL 1-13

Electrochemical analysis of bovine serum albumin imprinting CaAlg

based composite hydrogel sensor

Meng Qi1,2§§§§§, Kongyin Zhao1, 2, Lun Xia1

(1State Key Laboratory of Separation Membranes and Membrane Processes, Tianjin 300387,

China; 2School of Material Science and Engineering, Tianjin Polytechnic University, Tianjin

300387, China.)


The BSA electrochemical imprinted hydrogel sensor was fabricated by

introducing the organic-inorganic hybrid structure between calcium silicate/

mesoporous silica gel (CaSiO3@SiO2) and CaAlg into CaAlg hydrogel system onto

modified bare carbon electrodes. Due to the hydrogen bond interaction between

mesoporous silica gel and CaAlg, the mechanical and anti-swelling performance of

alginate hydrogel membrane had been significantly improved. It can be detected

quickly by voltammetry curves that the hydrogel sensor can quickly removed the

template molecules BSA in Tris-HCl buffer (pH=7.4). After five rebinding and

releasing cycles, the affinity of MIP sensor to BSA still remained above 80%,

indicating that MIP sensors possessed superior stability. MIP modified electrode also

showed good dynamic response in the range of 0.5~100 μmol*L-1 BSA concentration.

In addition, MIP hydrogel sensors monitored the selectivity of some protein similar

molecular weight and structure to BSA, such as bovine hemoglobin (BHb) and

ovalbumin (OVA). Therefore, it will have great potential applications in protein

release and sensor.

Keywords: Calcium alginate; Organic-inorganic; Bovine serum albumin;

Electrochemical imprinting hydrogel sensor

This research was supported by the National Natural Science Foundation of China (51708407) and

Tianjin Science Technology Research Funds of China (16JCZDJC37500).




June 14-17, 2019

49

OL 1-14

Ultrastiff and tough hydrogels with dense and robust hydrogen bond

complexes

Xin Ning Zhang1, Yan Jie Wang1,2, Hongyao Ding1, Yiping Zhao2, Zi Liang Wu1*,

Qiang Zheng1

（1 Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027,

China; 2 School of Materials Science and Engineering, Tianjin Polytechnic University, Tianjin

300387, China)


Hydrogels are usually recognized as soft and weak materials, the poor mechanical

properties of which greatly limit their applications as structural elements. So far, a

variety of tough hydrogels with typical network structures and different toughening

mechanisms. Some synthetic hydrogels are even tougher than soft biotissues.

However, in terms of stiffness, the tough hydrogels (Young’s modulus E: 0.01–1 MPa)

are much softer than the cartilages and skins (E up to 100 MPa). Although soft

hydrogels can achieve high strength and toughness via high stretchability, certain

applications of tough gels as structural elements still require high stiffness. Therefore,

designing tough and stiff hydrogels has both fundamental and practical significances.

Recently, we developed a series of tough and stiff hydrogels by forming dense and

robust hydrogen bonds between vinylimidazole and acrylic acid groups, which are

stabilized by the neighboring hydrophobic methyl groups. The resultant hydrogels

with water content of 50-60 wt% are stable in water and possesse excellent

mechanical properties, with tensile breaking stress, breaking strain, and Young's

modulus of 1-10 MPa, 100-600%, and 10-200 MPa, respectively. The dynamic nature

of hydrogen bonds also affords the hydrogels versatile functions, such as shape

memory, self-recovery, etc. These tough and stiff hydrogels should be an ideal

material as structural materials with promising applications in diverse fields.

Keywords: hydrogels, toughness, stiffness, hydrogen bonds



June 14-17, 2019

50

OL 1-15

Anisotropic All-Cellulose 3D Wrinkled Hydrogels with

Programmable Patterns for Cells Alignment

Dongdong Ye1******, Jie Zou1, Lina Zhang2

（1School of Textile Materials and Engineering, Wuyi University, Jiangmen 529020, China; 2College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China）


Wrinkled hydrogels from biomass sources are expected as potential structural

biomaterials. However, for bio-related applications, a scalable, structure-customized,

mechanically stable and biocompatible wrinkled hydrogels engineered with high

oriented nanostructure and controllable intervals is still a challenge. Herein, we

reported a scalable biomass material, namely cellulose for customizing wrinkled

hydrogels through an ultrafast acid-induced interface reconfiguration under

confinement in NaOH/urea aqueous system. After immersing a pre-stretched chemical

gel in an acid solution and relaxation within 20s, a fixed and strengthened of

outermost oriented structure was built, resulting in a consecutive outside-to-inside

modulus gradient and a self-wrinkled structure. The structure of wrinkled hydrogels

were programmable by tuning prestretching strains and reacting time for successfully

inducing cells alignment. We have opened up a new avenue to fabricate

polysaccharides-derived programmable oriented wrinkled hydrogels for biomedical

materials via a bottom-up method.

Keywords: Cellulose hydrogels, Wrinkled structure, Modulus gradient, Bottom-up

approach, Cells alignment

References:

[1]. Ye DD.; Yang PC.; Lei XJ.; Zhang DH.; Li LB., Chang CY*., Sun PC.; Zhang

LN*, Chem. Mater, 2018, 30, 5175-5183.

[2]. Ye DD.; Lei XJ.; Li T.; Cheng QY.; Chang CY.; Hu LB*.; Zhang LN*, ACS

Nano, 2019, 13, 4843-4853.

This research was supported by the scientific research startup funds for high-level talents of Wuyi

University (AL2018010).



June 14-17, 2019

51

OL 1-16

An injectable self-assembling collagen-gold hybrid hydrogel for

combinatorial antitumor photothermal/photodynamic therapy

Ruirui Xing1,2,3, Kai Liu3, Tifeng Jiao1,2,*, Ning Zhang3, Kai Ma1,2, Ruiyun Zhang1,2,

Qianli Zou3,*, Guanghui Ma3, Xuehai Yan3,*

(1State Key Laboratory of Metastable Materials Science and Technology, Yanshan University,

Qinhuangdao 066004, P. R. China; 2Hebei Key Laboratory of Applied Chemistry, School of

Environmental and Chemical Engineering, Yanshan University, Qinhuangdao 066004, P. R. China; 3National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese

Academy of Sciences, Beijing 100190 , P. R. China）

*E-mail: [email protected] (T. Jiao); [email protected] (Q. Zou); [email protected] (X. Yan).

An injectable and self-healing collagen-protein-based hydrogel is formed by a

gold-biomineralization-triggered self-assembly, which was mainly associated with the

electrostatic interaction between positively charged collagen chains and anionic

clusters ([AuCl4]− ions). Moreover, such biocompatible collagen-based hydrogels have

been developed as a novel tool for localized delivery and sustained release of

therapeutic drugs, with the advantages to reduce the drug dosage, to lower the toxicity,

and to improve the bioavailability. It has also been demonstrated that antitumor

efficacy can be significantly enhanced by combinatorial PTT/PDT treatments, without

pathologic lesion for primary organs, merely through one intratumoral injection of the

collagen-based hydrogels and increasing the laser irradiation times. Overall, the

injectable and self-healing collagen-based hydrogels we developed offer new

alternative opportunities for development of protein-based delivery vehicles and a

treatment strategy toward a broad range of biomedical applications such as drug

delivery and tissue engineering.



June 14-17, 2019

52

Keywords: Collagen-based hydrogel, Injectable, Self-healing, Biomedical

References:

[1] Xing RR.; Liu K.; Jiao TF.; Zhang N.; Ma K.; Zhang RY.; Zou QL.; Ma GH.; Yan

XH, Adv. Mater. 2016, 28, 3669-3676.

[2] Zhang RY.; Xing RR.; Jiao TF.; Ma K.; Chen CJ.; Ma GH.; Yan XH, ACS Appl.

Mater. Inter. 2016, 8, 13262-13269.

[3] Xing RR.; Jiao TF.; Yan LY.; Ma GH.; Liu L.; Dai LR.; Li JB.; Möhwald H.; Yan

XH, ACS Appl. Mater. Inter. 2015, 7, 24733-24740.

[4] Xing RR.; Jiao TF.; Ma K.; Ma GH.; Möhwald H.; Yan XH, Sci. Rep. 2016, 6,

26506.

-------------------------------------------


21872119), Support Program for the Top Young Talents of Hebei Province, and Research Program

of the College Science & Technology of Hebei Province (No. ZD2018091).



June 14-17, 2019

53

OL 1-17

PAM/CaAlg/CaSiO3@SiO2 composite hydrogel with high strength,

good transparency and low swelling under physiological environment

Kong Yin Zhao1,2††††††, Meng Qi1, Guo Qing Xu1

(1State Key Laboratory of Separation Membranes and Membrane Processes, Tianjin Polytechnic

University, Tianjin 300387, China;2School of Material Science and Engineering, Tianjin

Polytechnic University, Tianjin 300387, China.)


High strength PAM/CaAlg/CaSiO3@SiO2 composite hydrogel with high strength,

good transparency and low swelling under physiological environment was prepared

by dissolving sodium silicate, acrylamide (AM) and sodium alginate (NaAlg) in water,

inducing acrylamide polymerization, crosslinking sodium alginate with calcium ion

and soaking in gluconic acid-gain-lactone (GDL) aqueous solution. Organic-inorganic

hybrid structures between calcium silicate/mesoporous silica gel (CaSiO3@SiO2) and

alginate, the hydrogen bonding between CaSiO3@SiO2 nanoparticles and polymer

matrix (PAM and CaAlg) and the CaSiO3@SiO2 nanoparticles improve the stability

of the hydrogel in physiological environment. The composite hydrogel membrane was

characterized by SEM, TEM, Circular dichroism spectrum (CD) and Raman

spectrometer. The multi-scale computer simulation is developing to mathematically

describe the behavior of PAM/CaAlg/CaSiO3@SiO2 and PAM/CaAlg hydrogel. The

mechanical properties and swelling properties of the hydrogel film in saline were

discussed. The composite hydrogel membrane has solved the problem of low strength

and poor stability of the traditional hydrogel. This paper provides a novel method to

develop hydrogel materials for prospective applications in biomedicine, tissue

engineering, regenerative medicine, and optical biological devices.

Keywords: PAM/CaAlg/CaSiO3@SiO2; High strength hydrogel; Mechanical

properties; swelling properties; Stability in physiological environment


Tianjin Science Technology Research Funds of China (16JCZDJC37500).




June 14-17, 2019

54

OL 1-18

Multicolor Fluorescent Polymeric Hydrogels: Fabrication and

Sensing/Actuating applications

Wei Lu‡‡‡‡‡‡

, Jia Wei Zhang, Tao Chen

（Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences,

Ningbo 315201, China.）


Fluorescent polymeric hydrogels are highly swollen and hydrophilic 3-D networks

with tunable luminescent properties.[1] Their hydrophilic 3-D polymeric network

structure significantly facilitate the substance exchange with surrounding aqueous

solutions to induce visible fluorescence response, making them particularly useful for

biological imaging, luminescent sensing, information encoding and transforming, etc.

However, most studies primarily focus on fluorescent polymeric hydrogels with

single-color emission, the research of multicolor fluorescent ones is highly lagging,

which seriously limits their application in many areas. To this end, we recently

produce new-type multicolor fluorescent polymeric hydrogels simultaneously grafted

with stimuli-responsive red-, green- and blue-light-emitting fluorophores. These

hydrogel films could be used to construct fluorescent chemosensors[2~4] or actuators

with on–off switchable and color-tunable fluorescence behaviors.[5~6]

Keywords: Multicolor fluorescence, Hydrogel, Chemosensors, Actuators

References:

[1] Lu, W.; Le, X.; Zhang, J.; Huang, Y. ; Chen, T., Chem. Soc. Rev. 2017, 46, 1284.

[2] Li, P.; Zhang, D.; Zhang, Y.; Lu, W.*; Wang, W.; Chen, T., ACS Sens. 2018, 3,

2394.

[3] Zhang, D.; Zhang, Y.; Lu, W.*; Le, X.; Li, P.; Huang, L.; Zhang, J.; Yang, J.;

Serpe, M. J.; Chen, D.; Chen, T., Adv. Mater. Technol. 2018, 1800201.

[4] Lu, W.; Zhang, J.; Huang, Y.; Théato, P.; Huang, Q.; Chen, T., ACS Appl. Mater.

Interfaces 2017, 9, 23884.


21774138, 21504100).

https://pubs.acs.org/doi/10.1021/cm052251i#cm052251iAF1

https://pubs.acs.org/doi/10.1021/cm052251i#cm052251iAF1



June 14-17, 2019

55

[5] Ma, C. X.; Lu, W.; Yang, X.; He, J.; Le, X.; Wang, L.; Zhang, J.; Serpe, M.;

Huang, Y.; Chen, T., Adv. Funct. Mater. 2018, 1704568.



June 14-17, 2019

56

OL 1-19

Mechano-responsive, tough and antibacterial zwitterionic hydrogels

with controllable drug release for wound healing

Kun Fang1,2, Rong Wang1,*, Donglei Liu2,*, Fanrong Ai2, Jun Fu1,*

（1Polymers and Composites Division, Ningbo Institute of Materials Technology and Engineering,

Chinese Academy of Sciences, Ningbo 315201, China; 2School of Mechanical and Electrical

Engineering, Nanchang University, Nanchang 330031, China）


Abstract: Wound treatments, especially for chronic wounds or those under stresses

and deformations, have attracted great attentions. Because of frequent external stress

or strain, the healing process of these wounds could be easily interfered, and result in

infection and delayed healing. Smart hydrogels can control drug release upon external

stimulations, such as pH, temperature, light, etc.. However, many of these hydrogels

have low mechanical property, and cannot be used for wounds under stresses and

deformations. Herein, we developed a novel tough mechano-responsive zwitterionic

hydrogel using drug-loaded acrylated Pluronic® F127 micelles as macro-crosslinker

and sulfobetaine methacrylate as monomer. Rifampicin, as a model hydrophobic

antibiotic, was loaded in acrylated F127 micelles. The hydrogel has excellent

mechanical properties, with the ultimate tensile strength and tensile strain up to 112

kPa and 1420%, respectively, and the compressive stress up to 1.41 MPa. The release

of antibiotic from the hydrogel could be controlled by the extent and cycles of

mechanical strain/stress. The hydrogel exhibits excellent antibacterial property against

Staphylococcus aureus and Staphylococcus epidermidis. In addition, drug penetration

into skin tissue was enhanced under mechanical stress of the hydrogel. Such a tough

mechano-responsive hydrogel holds great promise for chronic wound treatment.

Keywords: Mechano-responsive, antibacterial, tough hydrogels, wound healing, drug

release.

References:

[1]. Xu D.; Gao G.; Xiao Y.; Wang Z.; Chen J.; Zhou Y. Wang R.*; Yin J.*; Fu J.*, J.

Polym. Sci., Part B: Polym. Phys. 2019, 57, 473-483.

[2]. Wang R.; Chua K. L.*; Neoh K. G.*, ACS Biomater. Sci. Eng., 2015, 1, 405-415.

This research was supported by the National Natural Science Foundation of China (51803229).



June 14-17, 2019

57

OL 1-20

Macroscopic Supramolecular Assembly of Hydrogels Based on

Host/Guest Polymer Brushes

Yawen Xu, Yang Zhou, Jing Chen*, Jun Fu*

(Ningbo Institute of Materials Technology & Engineering, Chinese Academy of Sciences, 1219

Zhongguan West Road, Ningbo 315201, China.)

*E-mail: [email protected] or [email protected]

As the most human-made materials to biological systems, hydrogels have been

employed to manufacture multifunctional smart device [1-3]. The network of hydrogels

is commonly isotropic, however, which is substantially differentiated from the

well-defined anisotropic structure of most biological systems. Inspired by the

integrated circuit which achieves its function by assembling dissimilar components

organically together, an emerging philosophy in building anisotropic hydrogels is

macroscopic assembly [4]. Unfortunately, current achievements are empirical, to some

extent, on the interfacial interactions, being short of a highly controllable way to

precisely tailor the content, distribution and freedom of motion of surface

supramolecular groups. The macroscopic supramolecular assembly is thereby still in a

dilemma to be widely used due to its deficient reliability, controllability and flexibility

for fabricating sophisticated devices. In this presentation, we will present an approach

to meet the challenge. Polymer brushes containing complementary host

(β-cyclodextrin)/guest (adamantane) groups are separately in-situ grafted from

surfaces of two hydrogel blocks via surface-initiated atom transfer radical

polymerization (SI-ATRP), leading to a stable macroscopic supramolecular assembly.

This assembling strategy not only improves the binding reliability independent of the

nature of assembling units, but also flexibly tunes the interfacial supramolecular

interaction by adjusting the chain length or host/guest content of brushes, which will

open a new door to manufacture multi-functional and multi-material assemblies in a

wide field of applications.

Keywords: Macroscopic supramolecular assembly, Hydrogel, Polymer brushes

References:

[1]. H. R. Lee, C. C. Kim, J. Y. Sun, Advanced Materials 2018, 30, e1704403.

[2]. H. Wang, C. N. Zhu, H. Zeng, X. Ji, T. Xie, X. Yan, Z. L. Wu, F. Huang,

Advanced Materials 2019, 0, 1807328.

[3]. T. Shay, O. D. Velev, M. D. Dickey, Soft matter 2018, 14, 3296-3303.

[4]. C. Ma, T. Li, Q. Zhao, X. Yang, J. Wu, Y. Luo, T. Xie, Advanced Materials

2014, 26, 5665-5669.





June 14-17, 2019

58

OL 1-21

Natural Triterpenoid-Tailored Phosphate: In Situ Reduction of

Heavy Metals Spontaneously to Generate Electrochemical Hybrid

Gels

Yuxia Gao1, Fengpei Du1, Jun Hu2§§§§§§

（1Department of Applied Chemistry, China Agricultural University, Beijing 100193, China; 2Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University

of Chemical Technology, Beijing 100029, China）


Hydrogels, consisting of three-dimensional networks formed by molecular

self-assembly to encapsulate water, have attracted much attention for a wide range of

potential applications, especially in conductive materials. In this work we have

designed and synthesized a natural triterpenoid-tailored phosphate (MGP), and this

amphiphilic MGP could form stable hydrogel and extract gold salt from water,

followed by spontaneous in situ Au nanoparticles (AuNPs) formation without external

reductants. Notably, the AuNPs were mainly localized on gel fibers rather than in

solvent pockets, and the resulting MGP-AuNPs hybrid gel exhibited attractive

electrocatalytic and conductive properties. In addition, as an efficient leaching

extraction agent, MGP hydrogel showed higher affinity towards heavy metals over

other common metals on account of the high reduction potential of heavy metals. This

work not only provides a novel yet simple way in generating electrochemical hybrid

gels by in situ reduction of heavy metals spontaneously, but also expands the

application of nature product-based functional materials.

Keywords: Gel, Triterpenoid, Nanoparticles, Electrochemistry, Self-assembly

References:

[1]. Gao YX.; Hao J.; Yan Q.*; Du FP.; Ju Y.; Hu J.*, ACS Appl. Mater. Interfaces

2018, 10, 17352.

[2] Gao YX.; Hao J.; Liu JG.; Liang Y.; Du FP.; Hu J.*; Ju Y*, Mater. Chem. Front.

2019, 3, 308.


21802166) and Chinese Universities Scientific Fund (2019TC013, 2019TC109).



June 14-17, 2019

59

OL 1-22

High-strength and Self-Healing Hydrogel Based on

Carboxymethylcellulose

Nan Li 1， Wei Chen 1*

（1 College of Engineering, Qufu Normal University, Rizhao, 276826, China）


Hydrogels are the focus of extensive research due to their potential applications

in various fields including tissue engineering, drug delivery, soft actuators, and

sensors, etc. However, insufficient functionality and weak mechanical properties limit

their practical utilities. Herein, we developed a simple approach to fabricate strong,

tough, and self-healable hydrogel by introducing CMC into poly (acrylic acid)

(PAA)-Fe3+ hydrogel as well as by simply soaking the gel in sodium chloride

solution. The synergetic interactions of -COO-/Fe3+ physically ionic network as well

as PAA covalent network can homogeneously distribute stress, and more importantly,

a high degree of network density, and chain entanglement introduced by soaking

treatment could act as “sacrificial bonds” to dissipate energy effectively.

Additionally, the noncovalent ionic interactions serve as dynamic but stable

associations, leading to the effective self-healing efficiency over 90 % after damage.

We expect that this facile strategy by integrating the biocompatible and biodegradable

CMC and then soaking in NaCl solution may enrich the avenue in exploration of

high-strength, toughness and self-healing cellulosic hydrogels to expand their

potential applications in various fields.

Keywords: Carboxymethylcellulose, DN Hydrogels, Self-healing, High mechanical

properties




June 14-17, 2019

60

OL 1-23

Ultrastiff and Tough Supramolecular Hydrogels with a Dense and

Robust Hydrogen Bond Network

Yan Jie Wang1, 2, Li Chen2, 3, Zi Liang Wu1*, Qiang Zheng1

（1Ministry of Education Key Laboratory of Macromolecular Synthesis and Functionalization,

Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China; 2State Key Laboratory of Separation Membranes and Membrane Processes, School of Materials

Science and Engineering, Tianjin Polytechnic University, Tianjin 300387, China; 3School of

Materials Science and Engineering, Tianjin University of Technology, Tianjin 300384, China）

*E-mail: [email protected].

Synthetic tough gels are usually much softer than some biotissues (e.g., skins

with modulus up to 100 MPa). Here we report a new class of ultrastiff and tough

supramolecular hydrogels facilely prepared by copolymerization of methacrylic acid

and methacrylamide. The gels with water content of approximately 50−70 wt %

possessed remarkable mechanical properties, with Young’s modulus of 2.3−217.3

MPa, tensile breaking stress of 1.2−8.3 MPa, breaking strain of 200−620%, and

tearing fracture energy of 2.9−23.5 kJ/m2, superior to most existing hydrogels,

especially in terms of modulus. Typical yielding and crazing were observed in the gel

under tensile loading, indicating the forced elastic deformation of these hydrogels in a

glassy state, as confirmed by dynamic mechanical analysis. The ultrahigh stiffness

was attributed to the dense cross-linking and reduced segmental mobility caused by

the robust intra- and interchain hydrogen bonds. Because of the dynamic nature of

noncovalent bonds, these gels also showed rate-dependent mechanical performances

along with good shape memory and recyclability. This strategy should be applicable

for other systems toward robust mechanical properties, versatile functionalities, and

promising applications of hydrogel materials as structural elements.

Keywords: Supramolecular gels, High stiffness, Yielding, Hydrogen bonds,

Recyclability

References:

[1]. Wang YJ#.; Zhang XN#.; Song Y.; Zhao Y.; Chen L.; Su F.; Li L.; Wu ZL*;

Zheng Q, Chem. Mater. 2019, 31,1430



June 14-17, 2019

61

OL 1-24

Alginate-based hydrogel microcapsules for immobilized biocatalysis

Xiudong Liu1,*, Huijing Li1, Xiaojun Ma2

（1College of Environment and Chemical Engineering，Dalian University, Dalian 116622, China; 2Dalian Institute of Chemical Physics，Chinese Academy of Sciences, Dalian 116023, China.）


Biocatalysis techniques have been widely applied in industrial biotechnology and

substituted some traditional chemical synthetic routes regarding to the high selectivity,

mild and environment benign condition. However, it is still a challenge to maintain

the activity and stability of biocatalysts in hostile environment. Immobilization of

biocatalysts in carriers is an industrial potential technology to solve the above

problem and has been studied with many materials.

Alginate is a biocompatible polysaccaride, which can transform from sol into

hydrogel under divalent cations. Based on our specialty in hydrogel microcapsule

technology and cell culture, alginate-chitosan (AC) hydrogel microcapsules were

prepared as immobilization carrier by emulsification-internal gelation and

complexation reaction. Yeast cells with biotransformation ability were immobilized in

AC microcapsules, and studied on the cell growth and metabolism properties in the

culture medium-solvent two phase systems. AC microencapsulated yeast cells can

keep activity and grow without adverse effect by two phase systems. Meantime, the

product concentration (aromatic alcohol) can reach above 5 g/L with substrate

concentration of 8-16 g/L, which was almost two-fold than that by free yeast cells.

Keywords: Alginate, Chitosan, Hydrogel microcapsule, Immobilized biocatalysis

References:

[1]. Eş, I.; Vieira JDG.; Amaral AC., Applied Microbiology and Biotechnology,

2015, 99(5), 2065-2082.

[2]. Yu WT.; Song HY.; Zheng GS.; Liu XD.; Zhang Y.; Ma XJ., Journal of

Membrane Science, 2011, 377, 214-220.

[3]. Song HY.; Yu WT.; Liu XD.; Ma XJ., Carbohydrate Polymers, 2014, 108,

10-16. This research was supported by the National Natural Science Foundation of China (Grant No.

21276033), and the Liaoning Provincial BaiQianWan Talents Program (No. 2017-6).




June 14-17, 2019

62

OL 2-1

Natural triterpene-tailored supramolecular gels: chiral transfer and

amplification

Jun Hu1*******, Yuxia Gao2, Hao Zhang1, Yong Ju3

（1Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing

University of Chemical Technology, Beijing 100029, China; 2Department of Applied Chemistry,

China Agricultural University, Beijing 100193, China; 3Department of Chemistry, Tsinghua

University, Beijing 100084, China）


Triterpenes, naturally occurring compounds, have attracted increased attention in

field of supramolecular gels due to their rigid skeletons, multiple functional groups,

and unique stacking manners. Nevertheless, little research has been devoted to their

macroscopic chiral structures. To explore a strategy to realize the chirality translation

from molecules to nano/macro-scale using triterpenes as building blocks, we have

synthesized a series of pyridinium-contained triterpene amphiphiles. By adjusting the

linker length and the solvent composition, well-ordered helical ribbons with both

right- and left-handedness have been fabricated in a cooperative supramolecular

polymerization manner. Additionally, driven by electrostatic interactions between

pyridinium and silica precursor, the supramolecular chirality was successfully

imprinted onto the silica nanostructures using the gel-sol mineralization process. This

work illustrates a facile methodology for creating supramolecular chiral

nanostructures that originate from natural chiral products.

Keywords: Triterpene, Gel, Supramolecular chirality

References:

[1]. Gao Y.; Hao J.; Wu J.; Zhang X.; Hu J.*; Ju Y*, Nanoscale 2015, 7, 13568.

[2]. Gao Y.; Hao J.; Yan Q.; Du F.; Ju Y.; Hu J*, ACS Appl. Mater. Interfaces 2018,

10, 17352.

[3]. Gao Y.; Hao J.; Liu J.; Liang Y.; Du F.; Hu J.*; Ju Y*, Mater. Chem. Front. 2019,

3, 308.


21604085) and National Key R&D Program of China (Grant No. 2017YFD0200302).




June 14-17, 2019

63

OL 2-2

The “Morse Code” between Solvent Polarity and Morphology

Flexibility

Si Chen, Tianyu Shan, Xu Wang*

（College of Materials Science and Engineering, Zhejiang University of Technology, Hangzhou

310014, China.）


LC physical gels are a new class of dynamically functional materials consisting

of LCs and fibrous aggregates of molecules that are called ‘‘gelators’’, exhibiting

induced or enhanced electro-optical, photochemical, and electronic properties[1].

Phase-separated structures are formed in LC physical gels by the combination of two

components, which can further affect it’s photoelectric performance due to the change

of interface action on the boundary regions. Hence the regulation of various

morphologies of LC gel is crucial.

Nevertheless, researches based on solvents-induced morphology are always

focused on common solvents rather than the LCs, which may due to LCs’ unaware

solvent parameters. Herein, by measuring solvent polarity of LCs and quantitatively

comparing fiber flexibility, we connect solvent polarity with morphology flexibility

by a fitting function, which can even be generalized to common solvents. Besides,

additional coarse-grained molecular dynamics simulations unexceptionably support

our theory that the solvent polarity is just like the “morse code”, and the “morse code”

can be decoded as morphology flexibility by the fitting function we built. We hope it

could be a quick way to judge morphology flexibility before troublesome electron

microscope in supramolecular systems.

Keywords: Supramolecular chemistry, Self-assembly, Nanostructures, Solvent

polarity, Molecular simulation

References:

[1] Kuang GC.; Ji Y.; Jia XR.; Chen EQ.; Gao M.; Yeh JM.; Wei Y*, Chem. Mater.

2009, 21, 456




June 14-17, 2019

64

OL 2-3

Hierarchical Macroporous networks construct by Supramolecular

chiral self-assembly of POSS core dendrimers

Huiwen He1, Hao Zheng1, Si Chen1*, Xu Wang1*

（1College of Materials Science and Engineering, Zhejiang University of Technology, Hangzhou

310014, China. ）

*E-mail: [email protected], [email protected].

The accurately construction of supramolecular gel with well-defined nano

structures, size, and functions through supramolecular self-assembly has received

considerable attention over the past few decades. Macroporous materials which

contain ordered macroporous structure with pore size of 50 nm–5 μm are useful for

applications in catalysts, thermal insulation materials, electromagnetic shielding

material, photonic band gap materials, optoelectronic devices, microreactors, and

tissue engineering scaffolds. However, the formation of macroporous structures by

supramolecular self-assembly method remains a great challenge due to the difficulty

in controlled self-assembly for ordered hierarchical nanostructures which only rings

and toroids can be easily obtained. Herein we report the controlled formation of

macroporous “loofah-like” nano-structures from dendrimer organogelators with POSS

as the core and eight amino acids as the peripheral arms by precisely regulation of the

supramolecular chiral self-assembly. Through regulating the chemical structure of the

peripheral amino acids of dendrimer or the ee value of the two-component assembly

system, ordered fiber bundles, micro-rings, helix fibers, and hierarchical macroporous

“loofah-like” network structures can be accurately obtained. This approach

innovatively provides a method for constructing macroporous materials by using

hierarchical supramolecular chiral self-assembly of POSS based dendrimers.

Keywords: Gel, Macroporous, Dendrimer, POSS, Supramolecular Chiral

References:

[1] S. S. Babu, S. Mahesh, K. K. Kartha and A. Ajayaghosh. Chem Asian J, 2009, 4: 824-829.

[2] G. Tang, S. Chen, F. Ye, X. Xu, J. Fang and X. Wang. Chem. Commun., 2014, 50: 7180-7183.

[3] H. He, S. Chen, X. Tong, Y. Chen, B. Wu, M. Ma, X. Wang and X. Wang. Soft Matter, 2016,

12: 957-964.

[4] H. He, S. Chen, X. Tong, Z. An, M. Ma, X. Wang and X. Wang. Langmuir, 2017, 33:

13332-13342.



June 14-17, 2019

65

OL 3-1

Nanocellulose Based Bio-scaffold Routed For Biomedical

Applications

Arun Saini,Bai-Liang Xue, Xin-ping Li*

College of Bioresources Chemical and Materials Engineering,

Shaanxi University of Science and Technology, Xi’an 710021, Shaanxi, China

*Corresponding author, E-mail: [email protected], Tel.:029-86168236

An innovative approach towards material unification for advanced bio-applications

has been proposed here. Wholly cellulose based bio-scaffolds were developed by a

simple and green method as a durable antibacterial dressing. 3-D Bio-scaffolds,

reinforced with carboxylated cellulose nanocrystals (cCNCs) were prepared by simple

freeze-drying process using microfibrillated cellulose (MFC) as matrix. Natural

bio-extract (i.e. Cinnamomum cassia) was used as bio-solvent and was amalgamated

with the base cellulosic components to promote the bioactivity of 3-D Bio-scaffolds.

The optimum hydrophilic and hydrophobic balance in the prepared scaffolds have

improved their swelling characteristics with maintained structural stability in

water-based medium. The use of cCNCs can play an important role in improving their

mechanical and thermal properties. Additionally, the use of Cinnamon cassia can

supplement the scaffolds with efficient antibacterial activity required for their usage

as wound dressing materials. Further, due to the inherent flexibility exhibited by the

base MFC matrix, the prepared scaffolds have demonstrated a flexible behavior that is

considered beneficial in promoting cell adhesion activities. Initial investigations

related to the material formulation paves a way towards exploring these scaffolds as

an antibacterial wound dressing material.

Keywords: Microfibrillated cellulose; carboxylated CNCs; bio-extract; antibacterial

activity; biocompatibility.

References:

[1] Yadav C., MajiPK., Carbohyd. Polym.2018, 203, 396.

[2] Cheng, H.; Li, C.; Jiang, Y.; Wang, B.; Wang, F.; Mao, Z.; Xu, H.; Wang, L.; Sui,

X. J. Mater. Chem. B.2018, 6, 634.



June 14-17, 2019

66

OL 3-2

Controlled Self-Assembly of MXene-Polymer at Liquid/Liquid

Interfaces

Shaowei Shi1†††††††, Bingqing Qian1, Xinyu Wu1, Hao-Bin Zhang1, Thomas P.

Russell1,2

（1Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing

University of Chemical Technology, Beijing 100029, China. 2Polymer Science and Engineering

Department, University of Massachusetts, Amherst, Massachusetts 01003, USA.）


A new two-dimensional (2D) transitional metal carbide/nitride, MXene, has

become increasingly attractive for many potential applications such as energy storage,

sensors and electromagnetic interference shielding owing to its rich surface chemistry

and outstanding conductivity. However, assembly strategies of MXene to construce

macroscopic-scale functional assemblies, especially three-dimensional (3D) porous

materials, are very limited and challenging. In this work, based on liquid-liquid

interfaces, we developed a new janus-like MXene-surfactant by taking advantage of

the cooperative assembly of MXene and end-functionalized polymer ligand at the

water/oil interfaces, and realize the controlled self-assembly of MXene at water/oil

interfaces and the preparation of stable Pickering emulsions by regulating the

interactions between MXene ans polymer ligand. After that, using the Pickering

emulsions as templates, 3D porous materials of MXene were constructed with a

down-top approach. It is anticipated that this project will provide theoretical guidance

and technical support for the preparation of high performance macroscopic-scale

MXene assemblies and polymer nanocomposites,which is of great scientific

significance.

Keywords: MXene, Liquid-liquid interfaces, Nanoparticle-surfactant, Porous

materials

References:

[1]. Li Y.; Liu X.; Zhang Z.; Zhao S.; Tian G.; Zheng J.; Wang D.; Shi S.* Russell T.

P.*, Angew. Chem. 2018, 130, 13748-13752

This research was supported by the Beijing Natural Science Foundation (Grant No. 2194083).



June 14-17, 2019

67

OL 3-3

“Stiff-Soft” Binary Synergistic Aerogels with Superflexibility and

High Thermal Insulation Performance

Junyan Zhang1, Yanhua Cheng1*, Mike Tebyetekerwa1, Si Meng1, Meifang Zhu1*

,

Yunfeng Lu2

（1State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of

Materials Science and Engineering, Donghua University, Shanghai, 201620, China; 2 Department

of Chemical and Biomolecular Engineering, University of California, Los Angeles, CA 90095,

USA.）


Designing aerogel materials featuring both high thermal insulation property and

excellent mechanical robustness is of great interest for applications in superior

integrated energy management systems.[1] To meet the above requirements, we report

composite aerogels based on hierarchical “stiff-soft” binary networks, in which

secondary mesoporous polymethylsilsesquioxane domains intertwined by bacterial

cellulose nanofibrillar networks are connected in tandem. The resulting composite

aerogels are characterized by highly porous (93.6%) and nanosized structure with a

surface area of 660 m2 g-1, leading to the excellent thermal insulation performance

with a low thermal conductivity of 15.3 mW m-1 K-1. The integrated “stiff-soft” binary

nature also endow the composite aerogels with high flexibility that can conform to

various substrates as well as large tensile strength that can withstand more than 2.70 ×

104 times its own weight. These composite aerogels show multifunctionality in terms

of efficient wearable protection, controllable thermal management and ultrafast

oil/water separation. These favorable multi-features present composite aerogels ideal

for aerospace, industrial and commercial applications.

Keywords: composite aerogels, nanofibrils, superflexibility, high thermal insulation,

hydrophobicity

References:

[1]. P. C. Hsu; A. Y. Song; P. B. Catrysse; C. Liu; Y. C. Peng; J. Xie; S. H. Fan; Y.

Cui*, Science 2016, 353, 1019




June 14-17, 2019

68

OL 3-4

Highly Porous Polymer Aerogel Film - Based Triboelectric

Nanogenerators

Qifeng Zheng1, Liming Fang2*, Haiquan Guo3, Kefang Yang1, Zhiyong Cai4, Mary

Ann B. Meador3, Shaoqin Gong1

（1Department of Material Science and Engineering, University of Wisconsin-Madison, Madison,

WI 53706, USA; 2School of Materials Science and Engineering, South China University of

Technology, Guangzhou 510641, China; 3Ohio Aerospace Institute, Brookpark, OH 44142, USA; 4Forest Products Laboratory, USDA, Madison, WI 53726, USA）


A novel class of high performance polymer porous aerogel film-based

triboelectric nanogenerators (A-NGs) is demonstrated. The A-NGs, made of a pair of

highly porous polymer films, exhibit much higher triboelectric outputs than the

corresponding dense polymer film-based triboelectric nanogenerators (D-NGs) under

the same mechanical stress. The triboelectric outputs of the A-NGs increase

significantly with increasing porosity, which can be attributed to the increase in

contact area and the electrostatic induction in the porous structure, thereby leading to

additional charges on the porous surface. Remarkably, the A-NG fabricated using

porous chitosan aerogel film paired with the most porous polyimide (with a porosity

of 92%) aerogel film demonstrates a very high voltage of 60.6 V and current of 7.7

µA, corresponding to a power density of 2.33 W m-2, which is sufficient to power 22

blue light-emitting-diodes (LEDs). This is the first report on triboelectric

nanogenerators (TENGs) employing porous polymer aerogel films as both positive

and negative materials to enhance triboelectric outputs. Furthermore, enhancing the

tribopositive polarity of the cellulose aerogel film via silanization using aminosilane

can dramatically improve the triboelectric performance. Therefore, this study provides

new insights into investigating porous materials with tunable triboelectric polarities

for high performance TENGs.

Keywords: energy harvesting; porous polymer films; triboelectric nanogenerators

References:

[1]. Zheng, Q.#, Fang, L.#, Guo, H., Yang, K., Cai, Z., Meador, M. A. B., Gong, S.*,

Adv. Funct. Mater. 2018, 28, 1706365.




June 14-17, 2019

69

OL 3-5

Graphene-crosslinked CNT aerogel for the preparation of elastic

porous polymer composites

Fei Zhang, Zhi Xing Zhang, Wei Feng

（School of Materials Science and Engineering, Tianjin University, Tianjin Key Laboratory of

Composite and Functional Materials, Tianjin 300072, P.R China.）


The controllability in thermal/electrical conductivity is significant for application

in flexible strain-related device.[1] Due to the strength-elasticity

(compressibility/resilience) trade-off, the preparation of high-strength and elastic

polymer composites with controllable thermal and electrical conductivity is full of

challenges. In this work, we reported a novel approach to prepare three-dimensional

(3D) porous graphene-crosslinked CNT/polyimide nanocomposite with

stress-controllable thermal and electrical conductivity by constructing a 3D hybrid

carbon aerogel as template and conductive network. We first constructed a continuous

3D graphene-welded CNT (Gw-CNT) hybrid architecture as the continuous

conductive network and the elastic template for polyimide. In the process of preparing

Gw-CNT/polyimide composites, polyimide was coated on the surface of carbon

skeleton layer by layer to obtain uniform composites with different micro-pore

structures, which is the key to realize the controllable elasticity of composites. The

resulting monoliths inherit the properties of polyimide and nano-carbon material

(graphene and CNT), with fine high temperature resistance (>500 ˚C), excellent

thermal (~10.89 W m-1 K-1) and electrical conductivity (~0.29 S m-1). And its

stress-controllable thermal and electrical conductivity makes the Gw-CNT/polyimide

composite can be an important candidate material for piezoresistive sensors.

Keywords: Graphene/CNT aerogel, polymer composites, Porosity, Thermally

conductivity, Electrical conductivity

References:

[1]. Zhang F.; Feng Y.; Qin M.; Ji T.; Lv F.; Li Z.; Gao L.; Long P.; Feng W*,

Carbon, 2019, 145: 378.


51573125).




June 14-17, 2019

70

OL 3-6

The Organic Acids Assisted Sol-Gel Method for Preparing Functional

Aerogels

Xiaoqing Wang, Mingjia Zhi* and Zhanglian Hong*

(State Key Laboratory of Silicon Materials, School of Materials Science and Engineering,

Zhejiang University, Hangzhou 310027, China.)

*E-mail: [email protected]; [email protected].

Here I am presenting a new class of gelators based on the low-cost organic acids

and the corresponding functional aerogels prepared from such gelators. A series of

organic acids such as citric acid, L-aspartic acid, DL-Mercaptosuccinic acid and

etidronic acid were adopted to initiate the sol to gel transition in the solution phase 1, 2,

3, 4. After supercritical drying, metal oxide, metal sulfide and metal phosphate aerogels

can be obtained with the characteristics similar with those of the conventional metal

oxide aerogels prepared by epoxide adding method. The composition of the final

aerogel can be readily tuned by choosing the organic acids with different functional

groups in the side chains. The detail gelation mechanism was analyzed by using

several different organic acids containing identical main chain but different side

groups. It is found that the complex interactions including covalent bond and

coordination bond interactions between organic acids and metal ions are vital to give

rigid gel network. Further modification of the aerogels included tuning the

mesoporous structure, compositing them with conductive graphene and carbon

nanotubes, and loading noble metal nanoparticles (Pt, Au etc). These results

demonstrated that these functional aerogels are good candidates for energy storage,

electrochemical H2 and O2 evolution catalyst and thermal insulation applications.

Keywords: Organic acid, Sol-gel, Aerogel, Gelator

References:

[1]. Wang XQ.; Li CY.; Shi ZY.; Zhi MJ.*; Hong ZL.*, RSC Advances 2018, 8,

8011-8020.

[2]. Wang XQ.; Wu ZX.; Zhi MJ.*; Hong ZL.*, J. Sol-Gel Sci. Techn. 2018, 87,

734-742.

[3]. Gao QY.; Wang XQ.; Shi ZY.; Ye ZR.; Wang WC.; Zhang N.; Hong ZL.*; Zhi

MJ.*, Chem. Eng. J. 2018, 331, 185-193.

[4]. Zhang Z.; Gao Q.; Liu Y.;Zhou C.;Zhi MJ.*; Hong ZL.*; Zhang F.; Liu B., RSC

Advances 2015, 5, 84280-84283.

This work is supported by National key research and development program (Grant No.

2016YFB0901600), Zhejiang Provincial Natural Science Foundation of China under

Grant No. LY19E020014, and NSCF (Grant No. 21303162 and Grant No. 11604295.



June 14-17, 2019

71

OL 3-7

Mesoporous Silica Nanoparticles as Nanocarriers for Controlled

Pesticide Release

Dr. Lidong Cao, Chunli Xu, Muhammad Bilal, and Qiliang Huang*

Key Laboratory of Integrated Pest Management in Crops, Ministry of Agriculture, Institute of

Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, China

Pesticides are widely used to improve the crop yield to meet the food demand of

the escalating global population and ensure sustainable development of modern

agriculture. However, depending on the methods of application and climatic conditions,

more than 90% of the applied pesticides are either lost in the environment or unable to

reach the target organisms, which not only increases the cost of treatment but also

produce undesirable side effect on the environment. With the rapid development of

nanoscience and nanotechnology in recent years, smart nano-delivery systems of

pesticides, which deliver the active ingredients slowly and sustainedly for longer

durations to a specified target sites at a desired rate, seem promising and have great

potential to address the current challenges that modern pesticides face. Since the

discovery of Mobil Crystalline Material 41 (MCM-41), research on and development

of mesoporous silica nanoparticles (MSNs) has gained worldwide interest due to

MSNs’ unique properties. In the present study, pesticides-loaded various

functionalized MSNs have been prepared, and the release profiles of cargo molecule as

well as the translocation, distribution and degradation behaviors of the target pesticide

in cucumber plants have been investigated. Moreover, the good bioactivity on target

plant without adverse effects on the growth of nontarget plant was also explored.



June 14-17, 2019

72

OL 4-1

Achieving Fracture-resistant Composite Hydrogels by Large

Energy-dissipative Process Zones

Yiwan Huang,a Daniel R. King,a,b Wei Cui,c Tao Lin Sun,a,b Honglei Guo,a,b Takayuki

Kurokawa,a,b Hugh R. Brown,e Chung-Yuen Hui,f Jian Ping Gong a,b,d

(a Faculty of Advanced Life Science, b Soft Matter GI-CoRE, c Graduate School of Life Science, d Institute for Chemical Reaction Design and Discovery (WPI-ICReDD), Hokkaido University,

Sapporo 001-0021, Japan; e ARC Centre of Excellence for Electromaterials Science and Australian Institute for Innovative Materials, University of Wollongong, NSW, 2522, Australia; f

Department of Mechanical and Aerospace Engineering, Cornell University, NY 14853, USA)

E-mail address: [email protected]

Fiber reinforced soft composites (FRSCs) have been developed recently by

combining tough but soft polyampholyte (PA) hydrogels with stiff yet flexible woven

glass fabrics.[1,2] In this work, we find that the soft composites show increased tearing

resistance with sample size and achieve size-independent, exceptionally high tearing

energy above a specific size on the centimeter scale. Such size-dependent tearing

behavior correlates with the failure mode change from fiber pull-out to fiber fracture.

These results demonstrate that the rigid fibers in the soft matrices transmit force over

a large distance, giving the composites very large process zones. Tremendous energy

is dissipated in the large process zones, resulting in the superior fracture resistance of

FRSCs. By saturation of the process zone size, the soft composites become

extraordinarily tough, showing an intrinsic tearing energy of ~1000 kJ m−2 that

outperforms other existing tough materials. These novel FRSC materials from

hydrated biocompatible hydrogels fill the gap between soft materials and traditional

rigid materials, as demonstrated by their high tensile modulus (several GPa) and

strength (> 300 MPa), along with exceptionally high tearing toughness (Fig. 1).[3]

Keywords: fiber reinforced hydrogels, super tough hydrogels, material failure modes,

energy-dissipative process zone, fracture model



June 14-17, 2019

73

Fig. 1. Fracture energy versus Young’s modulus map of materials. Our PA hydrogel composites

show superior fracture resistance.

References:

[1] D. R. King, T. L. Sun, Y. Huang, T. Kurokawa, T. Nonoyama, A. J. Crosby and J. P.

Gong, Mater. Horiz., 2015, 2(6): 584-591.

[2] Y. Huang, D. R. King, T. L. Sun, T. Nonoyama, T. Kurokawa, T. Nakajima and J. P.

Gong, Adv. Funct. Mater., 2017, 27(9): 1605350.

[3] Y. Huang, D. R. King, W. Cui, T. L. Sun, H. Guo, T. Kurokawa, H. R. Brown, C. Y.

Hui, J. P. Gong, J. Mater. Chem. A, 2019, published online, DOI:

10.1039/C9TA02326G.



June 14-17, 2019

74

OL 4-2

Bio-inspired hydrogel/organogel materials with special adhesion

Xi Yao1*, Junjie Liu2,3, Canhui Yang3, and Lie Chen4

（1Key Laboratory for Special Functional Materials, Ministry of Education, Henan University,

Kaifeng, Henan 475000; 2Department of Engineering Mechanics, Zhejiang University, Hangzhou,

Zhejiang, 310027; 3School of Applied and Engineering Sciences, Harvard University, Cambridge,

Massachusetts, 02138, USA; 4Beijing University, Beijing 100190）


Gel material, empowered by functions from both polymer networks and solvents,

enjoys significant applications in industry, medicine, daily life and scientific research.

However, it has not received much attention regarding to the technology development

of hydrogel coatings and the key scientific points within. In the past few years, we

have carried out research works based on hydrogel coating mechanics as well as

coating functionalization by super-wettability and special high/low adhesion,

anticipating applications in petroleum transport, microfluidics, anti-icing/de-icing,

medical devices, controlled drug release, etc.

Keywords: Hydrogel, Organogel, Wettability, Coating, Adhesion

References:

[1] Xi Yao, Lie Chen, Jie Ju, Changhua Li, Ye Tian, Mingjie Liu* and Lei Jiang,

Advanced Materials, 2016, 34, 7383–7389

[2] Xi Yao, Shuwang Wu, Lie Chen, Jie Ju, Zhandong Gu Mingjie Liu, Jianjun

Wang,* and Lei Jiang, Angewandte Chemie Internation Edition, 2015, 54, 8975

–8979

[3] Xi Yao, Jie Ju, Shuai Yang, Jianjun Wang*, Lei Jiang, Advanced Materials, 2014,

26, 1895-1900



June 14-17, 2019

75

OL 4-3

Mussel-Inspired Cellulose Nanocomposite Tough Hydrogels with

Synergistic Self-Healing, Adhesive, and Strain-Sensitive Properties

Changyou Shao, Lei Meng, Jun Yang*

（China. Beijing Key Laboratory of Lignocellulosic Chemistry, Beijing Forestry University, No 35,

Tsinghua East Road, Haidian, Beijing,100083, China）


The remarkable progress in efforts to prepare conductive self-healing hydrogels

mimicking human skin’s functions has been witnessed in recent years. However, it

remains a great challenge to develop an integrated conductive gel combining excellent

self-healing and mechanical properties, which is derived from their inherent

compromise between the dynamic cross-links for healing and steady cross-links for

mechanical strength. In this work, we design a tough, self-healing, and self-adhesive

ionic gel by constructing synergistic multiple coordination bonds among tannic

acid-coated cellulose nanocrystals (TA@CNCs), poly(acrylic acid)chains, and metal

ions in a covalent polymer network. The incorporated TA@CNC acts as a dynamic

connected bridge in the hierarchically porous network mediated by multiple

coordination bonds, endowing the ionic gels the superior mechanical performance.

Reversible nature of dynamic coordination interactions leads to excellent recovery

property as well as reliable mechanical and electrical self-healing property without

any assistance of external stimuli. Intriguingly, the ionic gels display durable and

repeatable adhesiveness ascribed to the presence of catechol groups from the

incorporated tannic acid, which can be adhered directly on human skin without

inflammatory response and residual. Additionally, the ionic gels with a great strain

sensitivity can be employed as flexible strain sensors to monitor and distinguish both

large motions (e.g., joints bending) and subtle motions (e.g., pulse and breath), which

enable us to analyze the data on the user interface of smart phone via programmable

wireless transmission. This work provides a new prospect for the design of the

biocompatible cellulose-based hydrogels with stretchable, self-adhesive, self-healing,

and strain-sensitive properties for potential applications in wearable electronic sensors

and healthcare monitoring.

Keywords: Hydrogel, Self-healing, Adhesive, Tough, Strain sensor



June 14-17, 2019

76

OL 4-4

Hollow hydrogel networks for temperature-controlled water fluidics

Qing Chen, Lidong Zhang‡‡‡‡‡‡‡

Department of Chemistry and Molecular Engineering, East China Normal University, Shanghai,

200241, People’s Republic of China

E-mail:[email protected]

ORCID Lidong Zhang: 0000-0002-0501-6162

Fabrication of multiply branched hollow hydrogel tubes (HTs) is still a challenge, and

an effective method is not available yet. We herein develop a cost-effective, facile

method for synthesis of multiply branched hollow HTs by direct conversion of

single-layer sodium alginate (SA) films to HTs in aqueous solution. The process does

not require special conditions, and HTs of arbitrary morphology and connectivity can

be prepared in a couple of minutes. The method provides access to branched HTs and

HT nets and grids of arbitrary shape and topology without the necessity to use

templates or molds. The wall of branched HTs can be functionalized to satisfy various

application requirements, which are demonstrated by controlled fluidics at high and

low temperatures, respectively. We also demonstrate that the hollow branched HTs

can be used as templates for preparation of other tubular networks with improved

mechanical properties.

Keywords: Sodium alginate, Hollow hydrogel network, Temperature-controlled

water fluidics, Hydrogel actuators

References:

[1]. Chen, Q.; Liang, S.; Zhang, L*, Chem. Commun. 2018, 54, 10304

[2]. Zhang, L*. et al. Adv. Mater., 2017, 29, 1702231.

[3]. Zhang, L, et al. Nat. Commun., 2015, 6:7429, 1-8.

[4]. Zhang, L.et al. Adv. Funct. Mater., 2016, 26, 1040-1053.

[5]. Zhang, L. et al. Angew. Chem. In. Ed., 2015, 54, 8642-8647.

[6]. Wei, J.; Wang, S.; Zhang, L*, ACS Appl. Mater. Interfaces, 2018, 10,

29161–29168


51603068).



June 14-17, 2019

77

OL 4-5

Deswelling behavior of pNIPAM composite gel consisting of

nanosheet liquid crystal whose orientation is controlled by

asymmetric electric field

Takumi Inadomi and Miyamoto Nobuyoshi*

（Department of Life, Environment and Materials Science, Fukuoka Institute of Technology,

3-30-1 Wajiro-higashi, Higashi-ku, Fukuoka, 811-0295, Japan）


We have recently reported

composite gels in which inorganic

nanosheet liquid crystals (LCs) are

aligned along two axes [1]. Here, we

report the composite gels with

asymmetrically and anisotropically

oriented nanosheet LCs. The

pre-polymerization solution was

prepared by adding

N-isopropylacrylamide (NIPAM) as a

monomer, a crosslinking agent, and a

photopolymerization initiator to an

aqueous nanosheet dispersion.

Alternating current electric field was

applied to the solution for 180 minutes using the point-to-line electrodes, followed by the

pre-polymerization solution was irradiated with ultraviolet light to proceed

photopolymerization. As shown in Fig. 1, nanosheets are oriented asymmetrically along

the fan-like electric flux line. The cross-sectional images show that the nanosheets are

separated into upper isotropic phase and lower LC phase. The volume fraction of the LC

phase was larger at the points with larger electric field, that is near the line electrode than

the point one. Because the configuration of the electrode is easily modifiable, the

composite gels with variety of embedded structure were further obtained. The present

gels show thermally-induced volume phase transition which is characteristic of pNIPA;

the composite gel exhibited characteristic bending behaviors depending on the

asymmetric and anisotropic structure.

Keywords: Nanocomposite gel, Inorganic nanosheet liquid crystal, Electric field

References:

[1]. T. Inadomi.; S. Ikeda.; Y. Okumura.; H. Kikuchi.; N. Miyamoto , Macromol. Rapid Commun.

2014, 35, 1741-1746.

Fig. 1. Polarized microscope image and schematic view of

orientation controlled nanosheet/pNIPAm composite gel.



June 14-17, 2019

78

OL 4-6

Strong and tough hydrogels with highly ordered and controllable

microstructure

Xiao Liu, Jian Hu*

（State Key Laboratory for Strength and Vibration of Mechanical Structures, School of Aerospace

Engineering, Xi’an Jiaotong University, Xi’an 710049, China.）


Hydrogels are similar to biological tissues owing to their specific soft and wet

properties, which are regarded as promising alternatives for artificial tissues. However,

conventional hydrogels are isotropic and lack the ordered internal microstructures,

which are far from the true structural and mechanical features of load-bearing soft

tissues such as muscle and cartilage. Herein, on the basis of mask photolithography

and double-network enhancement principle, we design a new type of soft-hard hybrid

hydrogel composites with well-ordered and controllable microstructure, where the

hard and soft phase are fabricated under the unmasked and masked region,

respectively. All of the obtained hydrogels with different patterns exhibit high tensile

strength, large stretchability, and high toughness. Especially, the striped hydrogels

exhibit remarkable anisotropic mechanical characteristic, as well as higher toughness

than both the hard and soft constituents. We further study the fracture process of the

striped hydrogels under uniaxial tensile by combining macroscopic mechanical test

with microscopic internal observation. A coupled stress-strain curve resulted from the

hard and soft phase is observed, and the decoupling process gives a clear physical

picture of the fracture and deformation of the hard and soft phase. This work provides

a new strategy to prepare strong and tough hydrogels with highly ordered and

controllable microstructure, which will make hydrogel materials better realize the

mechanical performance and functions of natural soft tissues.

Keywords: Hydrogels, Microstructure, Toughness, Fracture process, Double-network




June 14-17, 2019

79

OL 5-1

Structural constructions and multi-functions of biodegradable

polyurethanes

Feng Luo§§§§§§§

, Hong Tan

（College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials

Engineering, Sichuan University, Chengdu 610065, China）


In this report, we will introduce a series of biomedical polyurethanes (PU) with

various biological functions including antibacteria & antifouling, controlled

biodegradation, shape-memory, and so on, by elaborated multiblock design [1-4]. We

will try to uncover the coordinated relations between the multiblock construction of

PUs and the realization of biological functions.

Our findings indicate that the combination of antibacterial upper-layer and

antifouling sub-layer endow these surfaces strong, long-lasting antifouling and

contact-active antibacterial properties, with a more than 99.99% killing efficiency

against both gram-positive and gram-negative bacteria attached to them (Fig.1). Also,

a new Fmoc-diphenylalanine (Fmoc-FF) based peptide extender (PPE) is synthesized

for preparing a series of waterborne polyurethanes (WPUs) to construct a hydrophilic

surface and a hydrophobic subsurface (Fig.2). Such an architecture endows WPU

films with simultaneous biocompatibility, antifouling ability, and water resistance

under wet conditions.

Keywords: biodegradable polyurethanes, structural constructions, multi-functions

References:


51673126, 51873117, 51573114, 51425305).

Fig.1. The schematic of antibacterial and

antifouling gemini quaternary ammonium

salt WPU films.

Fig.2. hydrophilic surface and hydrophobic

subsurface constructed from waterborne

polyurethanes containing self-assembling

peptide extender.



June 14-17, 2019

80

1. Zhang F, Luo F *, Tan H * et.al., J. Mater. Chem. B, 2018,6, 4326.

2. Wang R, Luo F *, wang y* et.al., Macromolecular Bioscience, 2018,18（6），1800054.

3. Liu W, Luo F *, Tan H * et.al.,Macromolecular Rapid Communications,2017,38,1700450.

4. He W, Li J *, Tan H*, et.al., Scientific Reports, 2016, 6, 32140.

https://onlinelibrary.wiley.com/toc/15213927/2017/38/23



June 14-17, 2019

81

OL 5-2

Inducing Molecular Isomerization Assisted by Water

Dongsheng Wang*, Haiquan Zhao, Lei Zhao, Yonghao Zheng

（School of Optoelectronic Science and Engineering, University of Electronic Science and

Technology of China, No. 4, Section 2, North Jianshe Road, 610054, Chengdu, China.）


Donor-acceptor Stenhouse adducts (DASAs) are novel photoresponsive

molecules which were firstly synthesized in 2014 [1]. However, light is not the only

stimulus that can induce linear-to-cyclic isomerization of DASAs. In the present

research, the water-induced linear-to-cyclic isomerization of DASAs was

demonstrated and understood by density functional theory (DFT) calculations

(Scheme 1a). More importantly, the linear-to-cyclic isomerization is reversible under

heating. DASAs were applied in color switching under water vapor and heating

control (Scheme 1b). Stable cyclic DASAs coordinated with H2O molecules (cyclic

DASAs·xH2O) were isolated for the first time, which are useful for preparing

invisible inks for hand-writing and printing (Scheme 1c).

Scheme 1. Schematic illustration of light- and water-induced isomerization of DASAs

(a) and the related applications in color-switched inks (b) and invisible inks (c).

Keywords: DASAs, water-induced isomerization, DFT, invisible inks

References:

[1] Helmy, S.; Oh, S.; Leibfarth, F. A.; Hawker, C. J.; Read de Alaniz, J. J. Org.

Chem. 2014, 79, 11316-11329.




June 14-17, 2019

82

OL 5-3

Rational design of UCST polymers as functional materials guided by

a thermodynamic map

Chuanzhuang Zhao1, 2*, Louis Dolmans,2 Luqin Hua,1 X. X. Zhu2

（1 Faculty of Material Science and Chemical Engineering, Ningbo University, Ningbo, Zhejiang

315211, China. 2 Department of Chemistry, Universite de Montréal, C.P. 6128, Succursale

Centre-ville, Montreal, QC H3C 3J7, Canada;）


The rational design of polymers with tunable thermo-responsiveness is of both

theoretical and practical importance. In contrast to polymers with lower critical

solution temperature (LCST), polymers with upper critical solution temperature

(UCST) in aqueous milieu are relatively rare. We have proposed a thermodynamic

map to guide the rational design of such polymers.[1] The map is based on the

enthalpic and entropic contributions (ΔHm and ΔSm) to the free energy change of

mixing (ΔGm). The map is divided into four regions: soluble, insoluble, upper critical

solution temperature (UCST), and lower critical solution temperature (LCST), with

two lines representing the freezing and boiling point of water as two boundaries for

the UCST and LCST areas. The UCST or LCST of a polymer can be predicated as the

slope of the straight line that passing through the original point and the location of the

polymer on the map. With the help of such a map, we attempt to illustrate how the

UCST and LCST are affected by the interactions in polymer aqueous solutions, such

as hydrophobic interaction, hydrogen bonding and ionic interaction, so that the

thermo-responsive properties of a polymer can be predicted before synthesis. We

would also present our new designs of UCST polymers with multiple responsiveness

and UCST self-actuating hydrogels, which provides paradigms for the rational design

of UCST polymers as novel functional materials.

Keywords: thermo-responsive, UCST, hydrogen bond, hydrogel, actuator

References:

[1] Zhao C.,* Ma Z., Zhu X. X.,* Prog. Polym. Sci., 2019, 90, 269–291.




June 14-17, 2019

83

OL 5-4

Biocompatible photoluminescent silk fibers with stability and

durability

Yuan He1, Li Mei Zhang1, Yong Mei Chen1,2********

（1State Key Laboratory for Strength and Vibration of Mechanical Structures, International

Center for Applied Mechanics, School of Aerospace Engineering, Xi’an Jiaotong University, Xi’an

710049, China. 2Key Laboratory of Leather Cleaner Production, China National Light Industry,

National Demonstration Center for Experimental Light Chemistry Engineering Education,

College of Bioresources Chemical and Materials Engineering, Shaanxi University of Science &

Technology, Xian 710021, China;）


Exploring photoluminescent silk fibers, possessing biocompatibility as well as

stable and durable fluorescent properties, is a requirement for the development of

novel photoluminescent biomaterials. Herein, we fabricate photoluminescent silk

fibers, TPCA@SF, via modifying an organic fluorescent molecule

(5-oxo-3,5-dihydro-2H-thiazolo [3,2-a] pyridine-7-carboxylic acid, TPCA) onto silk

fibers, along with using quaternary ammonium salt didodecyldimethylammonium

bromide (DDAB) as color fixing agent. The hydrogen bonds and electrostatic

association among silk fibers, TPCA and DDAB ensure the stable modification. The

facile and green fabrication process is achieved in water under mild conditions

without using any toxic substances. The TPCA@SF manifests the combining features

of high quantum yield, fluorescence water-fastness, anti-photobleaching, good

mechanical property and biocompatibility. The strategy holds great potential for

exploring various biocompatible photoluminescent substances with stability and

durability.

Keywords: Silk fibers, Photoluminescence, Wash-durability, Anti-photobleaching,

Biocompatibility

References:

[1]. Shi, L.; Yang, J. H.; Zeng, H. B.; Chen, Y. M*.; Yang, S. C.; Wu, C.; Zeng, H.;

Yoshihito, O.; Zhang, Q., Nanoscale. 2016, 8, 14374-14378


11674263).




June 14-17, 2019

84

OL 5-5

From Shear-thickening Gel to Multifunctional Anti-impact Body

Armor

SHOU-HU XUAN

CAS Key Laboratory of Mechanical Behavior and Design of Materials, Department

of Modern Mechanics, University of Science and Technology of China (USTC),

Hefei, Anhui, 230027, China

Email: [email protected] Tel: +86-551-63601702

Keywords: Shear thickening gel, Body armor, Multifunctional, Impact

The shear-thickening gel (STG) is a typical visco-elastic material whose mechanical

properties are critically enhanced under applying the external forces. It behaves like a

soft plasticine in nature state but becomes very hard when suffering an external

impact. During the transition, the impact energy is absorbed to against the

deformation, thus the STG exhibits good impact protection performance. Recently,

the development of novel anti-impact body armor against the war and sports harmer

has attracted increasing needs. Considering the high flexibility, easy sealing and

rate-sensitivity characteristics, the ST materials have wide potential applications in

energy adsorption and body protection.

In this talk, a series of multifunctional anti-impact body armors based on the STG

are designed and there mechanical properties are intensively investigated. Unpon

introducing the magnetic particles, the anti-impact performance of the final materials

is controllable. Interestingly, the conductive STG exhibits an in situ sensitivity to the

external impact while it adsorbs the energy simulteneously. The

magnetic-electric-mechanic coupling mechanism is discussed and the

structure-dependent mechanical behaivor is studied. Moreover, due to the typical

shear thickening effect, the STG is favorable to improve the impact protecting

performance of Kevlar fabric. The combining of Kevlar fabrics with STG can not

only become a comfortable light material but also provide reliable protective and

energy dissipation performance as a personal body armor.




June 14-17, 2019

85

s

Fig 1. The high-speed photographs of the deformation and destruction of the samples

in the ballistic impact process.

REFERENCES

1 Wang, S., Gong, L.P., Shang, Z.J., Ding, L., Yin, G.S., Jiang, W.Q., Gong, X.L.,

Xuan, S.H., Novel safeguarding tactile e-skins for monitoring human motion

based on SST/PDMS-AgNW-PET hybrid structures, Advanced Functional

Materials, 28, 1707538, 2018.

2 He, Q.Y., Cao, S.S., Wang, Y.P., Xuan, S.H., Wang, P.F., Gong, X.L., Impact

resistance of shear thickening fluid/Kevlar composite treated with

shear-stiffening gel, Composites Part A: Applied Science and Manufacturing,

106, 82-90, 2018.

3 Xu, C.H., Wang, Y., Wu, J., Song, S.C., Cao, S.S., Xuan, S.H., Jiang, W.Q.,

Gong, X.L., Anti-impact response of Kevlar sandwich structure with silly

putty core, Composites Science and Technology, 153, 168-177, 2017.

http://gong.ustc.edu.cn/Article/2018C02.pdf







June 14-17, 2019

86

OL 5-6

A self-healing hydrogel with pressure sensitive photoluminescence for

remote force measurement and healing assessment

Weijun Li1, Qingwen Guan1, Ming Li1, Xiaojie Zhang1, Zhenhai Xia2, Quan

Xu1††††††††

（1State Key Laboratory of Heavy Oil Processing, China University of Petroleum-Beijing, 102249,

China; 2Department of Materials Science and Engineering and Department of Chemistry,

University of North Texas, Denton, Texas 76203, United States.）


Light-guiding materials capable of total internal reflection, remote mechanical

force sensing and self-healing are appealing in emerging fields including robotics and

optical force measuring instruments. However, achieving all these features in a single

material remains challenging at present. Herein, we have fabricated a

fluorescence-responsive self-healing hydrogel with a triple network structure, which

exhibits a 100% recovery in tensile strength after healing in air for 30 s and a 90%

recovery in tensile strength after healing in water for 60 s. Furthermore, this material

can resist a rotation of 1800° without breaking at the healed site. As the fluorescence

excitation intensity of the hydrogel shows a good correspondence with the forces

exerted on the hydrogel, the forces and the self-healing efficiency could be

determined by measuring the intensity of the excitation peak. The stress states of the

hydrogel in different liquids could be remotely monitored, eliminating the effect

surface contacts. With these sensing and self-healing abilities all in one, the

self-healing luminescent materials could be applied for tissue engineering,

photo-responsive biosensors, flexible light guiding devices, structural health

monitoring, etc.

Keywords: Self-healing; Hydrogel; Fluorescence-responsive; Optical force

measurement; Remote healing assessment

References:

[1]. Li M.; Li WJ.; Cai W.; Wang ZH.; Zhang XJ.; Street J.; Ong W-J.; Xia ZH, Xu

Q.* Mater. Horiz. 2019, 6, 703.


51875577).



June 14-17, 2019

87

OL 5-7

Controlled Phase Transitions of Dipeptide-based Gels

Jinbo Fei‡‡‡‡‡‡‡‡

, Junbai Li

（Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Lab of Colloid,

Interface and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences,

Beijing 100190, China.）


Tunable phase transitions of peptide-based supramolecular assemblies have found

wide applications. Different from traditional heat or solvent modulation, with the

cryogenic treatment at -196 oC, we observed phase transition from self-assembled

diphenylalanine organogel to hexagonal crystal. [1] The internal rearrangement of the

assembled molecules forms a crystal structure with chirality. Further, we explored

non-covalent introduction of a photoswitchable moiety to achieve reversible light

modulation of the dipeptide assembly. [2]Accompanying the isothermal recycled

gel-sol transition in a spatially controlled manner, well-defined renewable patterns

were fabricated. Also, we developed Schiff base covalent assembly to construct

dipeptide–protein hydrogels under mild condition. [3] Such assembled hydrogels are

sensitive to pH variation and simultaneously the proteins can be released without

changing the native secondary structures from the gels.

Keywords: Gel, Peptide, Molecular assembly, Phase transition

References:

[1] Liu XC#; Fei JB#; Wang AH; Cui W; Zhu PL; Li JB*, Angew. Chem. Int. Ed.

2017, 56, 2660.

[2] Li XB#; Fei JB#; Xu YQ; Li DX; Yuan TT; Li GL; Wang CL; Li JB*, Angew.

Chem. Int. Ed., 2018, 57, 1903.

[3] Yuan TT#; Fei JB#; Xu YQ; Yang XK; Li JB*, Macromol. Rapid Commun. 2017,

38, 1700408.


21573248 and 21872150), the Youth Innovation Promotion Association of CAS (Grant No.

2016032).



June 14-17, 2019

88

OL 5-8

Histidine-based Supramolecular π-gel: Dynamic Self-assembly and

Controlled Switching of Circularly Polarized Luminescence

Guanghui Ouyang*, Dian Niu, Minghua Liu*

CAS Key Laboratory of Colloid, Interface and Thermodynamics, Institute of Chemistry,

Chinese Academy of Sciences, Beijing, 100190, China


The switching of chirality and different self-assembly pathway are widely observed

in nature[1]. Inspired by the fascinating natural phenomena, the exploration of

dynamic supramolecular systems featuring chirality switching, in particularly

inversion, from enantiomeric pure gelators has attracted great attentions recently.

However, among the reported examples, the helicity and ground-state chirality

switching are the main focuses. As for circularly polarized luminescence (CPL)[2],

which reflects the excited state chirality, although the reversible switching between

emission and quenching state are discussed, the inversion and switching of CPL has

been rarely studied. Here, by designing a pyrene-conjugated histidine gelator, we

realized the inversion and switching of supramolecular chirality as well as CPL

through the cooperation of coordination and π-stacking interaction. This work not

only contributes to understand the chirality switching phenomena observed in

complicated natural systems, but also may shed light on developing smart chiroptical

materials based on π-gel systems[3].

Keywords: Supramolecular gel, Circularly polarized luminescence, Chirality

switching, Non-covalent interactions, Dynamic assembly.

References:

[1]. Liu M. H.*; Zhang L.; Wang T., Chem. Rev. 2015, 115, 7304.

[2]. Ji L.; Sang Y.; Ouyang G.*; Yang D.; Duan P; Jiang Y.; Liu M. H.*, Angew.

Chem. Int. Ed. 2019, 58, 844.

[3]. Niu D.; Jiang Y.; Ji L.; Ouyang G.*; Liu M. H.*, Angew. Chem. Int. Ed. 2019, 58,

5946.



June 14-17, 2019

89

OL 5-9

Biomimetic anisotropic hydrogel actuators

Jia Wei Zhang§§§§§§§§

, Chun Xin Ma, Xiao Xia Le, Li Wang, Tao Chen

（Division of Polymer and Composite Materials, Ningbo Institute of Material Technology and

Engineering, Chinese Academy of Science, Ningbo 315201, China）


Polymeric hydrogel actuators refer to intelligent stimuli-responsive hydrogels

that could reversibly deform upon the trigger of various external stimuli. They have

thus aroused tremendous attention and shown promising applications in many fields

including soft robots, biomimetic actuators, and so on. Inspired by the living

organisms, we have prepared a series of hydrogel actuators with anisotropic structures.

Through UV-reduction and locally polymerization, RGO-PNIPAM-PMAA hydrogel

actuator that can provide remote-controllable light-driven and thermo-, pH-, and ionic

strength-triggered multi-responsive 3D complex deformations have been achieved.

Inspired by the water self-circulation mechanism that contributes to the motion of

Mimosa leaves, we have constructed a bilayer hydrogel actuator with a UCST layer

and a LCST layer, which not only functions in water, but also in liquid paraffin and in

open-air. By combining a thermo-responsive actuating layer with a pH responsive

color-changing layer via macroscopic supramolecular assembly, a novel bilayer

hydrogel actuator with on–off switchable fluorescent color-changing function

behaviors have been developed. In addition, hydrogel actuators with integrated shape

memory function have been fabricated. Our strategy may provide new insights in the

design and fabrication of biomimetic intelligent systems.

Keywords: Hydrogel actuator, Anisotropic, Color-changing, Shape memory

References:

[1] Le XX., Zhang JW*., Chen T et al, Adv. Sci. 2019, 6, 1801584.

[2] Ma CX., Zhang JW*., Chen T et al, Adv. Funct. Mater. 2018, 28, 1704568.

[3] Zheng J., Zhang JW*., Chen T et al, J. Mater. Chem. C 2018, 6, 1320.

[4] Wang L., Zhang JW*., Chen T et al, Chem. Commun. 2018, 54, 1229.

[5] Ma CX., Zhang JW*., Chen T et al, Adv. Funct. Mater. 2016, 26, 8670.


51873223).




June 14-17, 2019

90

OL 5-10

Bioinspired Soft Sensing and Actuating Materials

Xuemin Du*********

Shenzhen Institutes of Advanced Technology (SIAT),

Chinese Academy of Sciences (CAS), Shenzhen, PR China


Bioinspired materials are originated from the inspiration of nature, such as

chameleon and Venus flytraps. Due to their intriguing properties, these materials have

been wisely explored in various research fields like sensors, actuators, robotics, etc.

Here, we would like to present our recent progress on chameleon-inspired structural

color materials firstly, including bio-inspired fabrications and sensing applications.

Then, the Venus flytraps-like actuators, which can change their shapes accordingly

after triggered with specific solvent, near-infrared light and temperature, are

followingly introduced. Based on the rapid progress in this field, we believe

bioinspired smart materials will find great potential applications in wearable and

implantable devices.

Keywords: Bioinspired materials, Structural color, Shape morphing, Sensors,

Actuators

References:

[1]. Du X.*; Cui H.; Zhao Q.; Wang J.; Chen H.; Wang Y., Research, 2019, DOI:

10.1155/2019/6398296

[2]. Zhao Q.; Wang J.; Cui H.; Chen H.; Wang Y.; Du X.*, Adv. Funct. Mater. 2018,

1801027

[3]. Zhang L.*; Naumov P.; Du X.*; Hu Z.; Wang J., Adv. Mater. 2017, 29, 1702231

[4]. Wang J.; Zhao Q.; Cui H.; Wang Y.; Chen H.; Du X.*, J. Mater. Chem. A 2018,

6, 24748

[5]. Du X. *; Cui H.; Sun B.; Wang J.; Zhao Q.; Xia K.; Wu T. *; Humayun M. S.,

Adv. Mater. Technol. 2017, 2, 1700120

This research was supported by the National Key R&D Program of China (2017YFA0701303).



June 14-17, 2019

91

OL 5-11

Hydrophobic Hydrogels with Fruit-like Structure and Functions

Hui Guo1,2, Tasuku Nakajima1,2,3, Dominique Hourdet2,4, Alba Marcellan2,4, Costantino

Creton2,4, Wei Hong2,5, Takayuki Kurokawa1,2, Jian Ping Gong1,2,3*

（1Laboratory of Soft & Wet Matter, Faculty of Advanced Life Science, Hokkaido University,

N21W11, Kita-ku, Sapporo, Hokkaido, 001-0021, Japan

2Global Station for Soft Matter, Global Institution for Collaborative Research and Education

(GI-CoRE), Hokkaido University, N21W11, Kita-ku, Sapporo, Hokkaido, 001-0021, Japan

3Institute for Chemical Reaction Design and Discovery (WPI-ICReDD), Hokkaido University,

N21W10, Kita-ku, Sapporo, Hokkaido, 001-0021, Japan

4Laboratoire Sciences et Ingénierie de la Matière Molle, ESPCI Paris, PSL University, Sorbonne

Université, CNRS, F-75005 Paris, France

5Department of mechanics and aerospace engineering, Southern University of Science and

Technology, Shenzhen, Guangdong 518055, P.R. China）


Normally, a polymer network swells in a good solvent to form a gel but the gel

shrinks in a poor solvent. Here, for the first time, we report an abnormal phenomenon:

some hydrophobic gels significantly swell in water, reaching water content as high as

99.6 wt% at most. Such abnormal swelling behaviors in the non-solvent water are

observed universally for various hydrophobic organo-gels containing omniphilic organic

solvents that have a higher affinity to water than to the hydrophobic polymers. The

formation of semi-permeable skin layer due to the rapid phase separation, and the

asymmetric diffusion of water molecules into the gel driven by the high osmotic pressure

of the organic solvent-water mixing, are found to be the reasons for such abnormal

swelling. As a result, the hydrophobic hydrogels have a fruit-like structure, consisting of

hydrophobic skin and water-trapped micro-pores, to display various unique properties,

such as significantly enhanced strength, surface hydrophobicity, anti-drying, despite their

extremely high water-content. Furthermore, the hydrophobic hydrogels exhibit selective

water absorption from concentrated saline solutions and rapid water release at a small

pressure as like to squeeze juices from fruits. These novel functions of hydrophobic

hydrogels will find promising applications, for example, as materials that can

automatically take the fresh water from seawater.

Keywords: Hydrophobic hydrogel, Phase separation, Semi-permeable skin, Asymmetric

diffusion, Seawater desalination



June 14-17, 2019

92

P 1-1

Investigation of photo-crosslinkable injectable poly(vinyl alcohol)

hydrogel for cartilage repair

Yachao Li, Liusheng Zha†††††††††

（State Key Laboratory for Modification of Chemical Fibers and Polymer Materials & College of

Materials Science and Engineering, Donghua University, Shanghai, 201620, China.）


Compared to traditional bulky hydrogel, injectable hydrogel is more suitable for

the application in cartilage repair due to the fact that it can be easily placed in

complex cartilage defect site (e.g., knee joint) and subsequently in situ form a

hydrogel of the exactly required shape, which benefits the adhesion of the artificial

cartilage to surrounding tissue because of their intimate contact and the mechanical

interlocking resultant from surface microroughness. The common injectable

hydrogels based on weak interactions, such as hydrogen bond and hydrophobic

interaction, have the disadvantage of weak mechanical strength, especially

compressive strength, which makes it difficult for them to meet the requirement of

cartilage repair. In this work, the poly(vinyl alcohol) (PVA) modified by glycidyl

methacrylate (GMA) was used to prepare a photo-crosslinked injectable hydrogel for

cartilage repair. The effect of the alcoholysis degree of PVA, the grafting percentage

of GMA, the used amount of photoinitiator, UV light intensity or its irradiation time

on compressive strength of the photo-crosslinked PVA hydrogel was investigated.

Finally, based on optimization of these conditions, the photo-crosslinked PVA

hydrogel of compressive strength of 1.27 MPa was obtained, which is superior to the

human cartilage (0.5 MPa).

Keywords: Injectable hydrogel, Photo-crosslinkable, Compressive strength

References:

[1]. Sivashanmugam A.; Arun Kumar R.; Vishnu Priya M.; Nair Shantikumar V.;

Jayakumar R* , European Polymer Journal, 2015, 72,543

[2]. Liu M.; Zeng X.; Ma C.; Yi H.; Ali Z.; Mou XB.; Li S.; Deng Y*.; He NY*,

Bone Research, 2017, 5,75


51373030).



June 14-17, 2019

93

P 1-2

A highly stretchable conductive polymer hydrogel by freeze-thaw-

shrink treatment for flexible electrodes

Lizhang Chen, Xiao Li*, Jinhui Xiao, Weiying Zhang, Xiaoguang Ying, Jianying

Huang

（Fujian Key Laboratory of Advanced Manufacturing Technology of Special Chemicals, College of

Chemical Engineering, Fuzhou University, Quanzhou 362100, China.）


Conductive polymer hydrogels combine the advantages of both conductive

macromolecules and hydrogels and play an important role in flexible electronic devices.

However, the mechanical properties and electrochemical properties often cannot meet

the requirements at the same time, which greatly limits their application. With the high

absorbent polymer hydrogel as the substrate, we developed a conductive hydrogel

composed of polyaniline and poly(acrylamide-co-sodium acrylate) by simple

freeze-thaw-shrink treatment. The conductive hydrogel exhibits a high elongation at

break of 1245% and a large area specific capacitance of 849 mF/cm2. This study

provides a new idea for the design of conductive polymer hydrogels, making it possible

to further apply conductive polymer hydrogels in flexible electronic devices.

Keywords: Conductive polymer hydrogel, Polyaniline, Freeze-thaw-shrink treatment,

Flexibility

References:

[1] Y. Huang, H.F. Li, Z.F. Wang, M.S. Zhu, Z.X. Pei, Q. Xue, Y. Huang, C.Y. Zhi,

Nanostructured Polypyrrole as a flexible electrode material of supercapacitor, Nano

Energy, 22 (2016) 422-438.

[2] W. Zeng, L. Shu, Q. Li, S. Chen, F. Wang, X.M. Tao, Fiber-Based Wearable

Electronics: A Review of Materials, Fabrication, Devices, and Applications, Adv.

Mater., 26 (2014) 5310-5336.

* This research was supported by the Special Support Program for High-level Talents of Fujian

Province and the Natural Science Foundation of Fujian Province, China (Grant No. 2019J01652).



June 14-17, 2019

94

P 1-3

Peptide nanofiber hydrogels to vascularization in skin regeneration

Bin Chu1,2‡‡‡‡‡‡‡‡‡, Jin Mei He1, Chang Sheng Chen1，Mei Tu2

（1Key Laboratory of Biomedical Materials and Implant Devices, Research Institute of Tsinghua

University in Shenzhen, Shenzhen 518057, China; 2 Department of Biomedical Engineering, Jinan

University, Guangzhou 510632, China）


Capillary network plays a vital role for regenerative medicine applications,

including treatment of ischemic tissue disorders and engineering tissues that are > 200

μm thick. In this study, we designed peptide-based self-assembling nanofiber

hydrogels containing angiogenic peptide segment (Ten-2) that specifically address

this challenge. Our peptides have an innate tendency to self-assemble into nanofibers,

forming biomimetic hydrogel scaffolds which are non-immunogenic and

non-cytotoxic. The hydrogels were conducive to adhesion and proliferation of Human

fibroblasts (L929) and Human umbilical vein endothelial cells (HUVEC). Meanwhile,

they could promote the formation of HUVEC tube, denoting a promising comfortable

environment for pro-angiogenic, and in vivo studies demonstrated that the hydrogels

showed no excessive inflammatory reaction. Moreover, new blood vessels were

observed under anadesma in mouse subcutaneous implantation test, and full-thickness

skin defect repair showed the hydrogels had increased skin repair speed and provided

a suitable wound repair environment for revascularization and tissue regeneration. In

short, this work presented a angiogenic peptide based self-assembling hydrogel

scaffold with steerable injectable properties and excellent biocompatibility,

pioneering the promising applications in skin regeneration.

Keywords: peptide, self-assemble, nanofibres, hydrogel, skin regeneration

References:

[1]. Song, H.-H. G.; Rumma, R. T.; Ozaki, C. K.; Edelman, E. R.; Chen, C. S., Cell

stem cell. 2018, 22, 340-354.

[2]. Rouwkema, J.; Rivron, N. C.; van Blitterswijk, C. A., Trends in biotechnology.

2008, 26, 434-441.

[3]. Griffith, L. G.; Naughton, G., Science, 2002, 295, 1009-1014.

This research was supported by the National Natural Science Foundation of China (Grant

No.51403116) and the Natural Science Foundation of Guangdong Province (2015A030313698).



June 14-17, 2019

95

P 1-4

Anti-freezing ZwitterionicPoly(ionic liquid) hydrogel-based

multimodal artificial skin

Ziyang Liua,†,Yue Wangb,†,Yongyuan Rena,Ying Yangc,Wei Chenc,*,Feng Yan a,*

aDepartment of Polymer Science and Engineering, College of Chemistry, Chemical

Engineering and Materials Science, Soochow University, Suzhou 215123, China; bDepartment of Electrical and Computer Engineering, University of Illinois at

Urbana-Champaign, Urbana, Illinois 61801, USA; cResearch Centerfor Smart Wearable Technology, Institute of Textiles and Clothing, The Hong

Kong Polytechnic University, Hong Kong 999077, P. R. China.


Ionotronic devices, capable of transmitting electrical signals over long distance,

are of great significance in soft robots, wearable devices and artificial sensors.

However, profound challenges remain in the adaptability of ionotronic devices to

varied environmental conditions, such as low temperature. Herein, an anti-freezing

zwitterionic poly(ionic liquid) hydrogel (PIL gel) was designed and synthesized for

the application of a multimodal artificial skin. Thezwitterionic PIL gel exhibited

super-stretchability at -20 ℃ (~900 %), self-healing ability and high conductivity

even under a low temperature (-30℃). Based on our zwitterionic PIL hydrogel, three

modes in one device, including capacitive, resistive and triboelectric sensing modes,

can be easily switched according to different ranges of pressure, strain, and

temperature. This work not only presents a novel structure for tough hydrogel below

water freezing temperature but also provided a simple design and fabrication of a

multimodal sensor, which may suggest a new approach for developing smart devices

with multifunctionality to adopt varied environmental parameters.

Keywords:poly(ionic liquid); ionic skin; multimodal sensor; anti-freezing hydrogel

References:

[1].Ziyang Liua,†,Yue Wangb,†,Yongyuan Rena,Ying Yangc,Wei Chenc,*,Feng Yan

a,*in preparation.

This work was supported by the National Nature ScienceFoundation for Distinguished Young

Scholars (21425417),the National Natural Science Foundation of China (21835005, U1862109),

and by the Priority AcademicProgram Development of Jiangsu Higher EducationInstitutions.




June 14-17, 2019

96

P 1-5

Synthesis and properties of a Tough and multifunctional hydrogel

based on grape seed polymer

Chun Hui Luo1§§§§§§§§§, Ning wei1

（1College of Chemistry and Chemical Engineering, North Minzu University, Yinchuan, Ningxia

750021, China.）

*Email: [email protected]

The development of hydrogel with superior mechanical properties and

multi-functionalities has attracted enormous scientific interests. Herein, a tough and

multifunctional hydrogel, comprised of grape seed polymer and hydrophobically

associated polyacrylamide (GSP-HPAM) double network, is fabricated by simply

mixing and in-situ polymerization. The GSP-HPAM DN hydrogel exhibit improved

mechanical properties, i.e., the tensile strength, strain and compression stress of

GSP/HPAM DN hydrogel are 0.7 MPa, 3000% and 28.3 MPa, respectively, which are

5-, 2.5- and 3-fold higher than that of pure HPAM hydrogel. Besides, the GSP-HPAM

DN hydrogels are free-shapeable, crack-resistant, notch-insensitive and self-healable,

which might arise from the combination of hydrophobic interaction of HPAM and

ionic bond between GSP and calcium ions. Due to the introduction of GSP, the DN

hydrogel also exhibits pH-sensitivity, radical scavenging ability, UV-blocking

property and electrical conductivity. These GSP-based DN hydrogels might expand

the application areas of hydrogels into controlled drug release and artificial skin.

Keywords: Grape seed polymer, pH-sensitivity, Radical scavenging ability,

UV-blocking property, Electrical conductivity

References:

[1]. Taylor, D. L.; In Het Panhuis, Advanced Materials. 2016, 28 (41), 9060-9093.

[2]. Keplinger, C.; Sun, J. Y.; Foo, C. C.; Rothemund, P.; Whitesides, G. M.; Suo, Z.,

Science 2013, 341 (6149), 984-7.


21464001).



June 14-17, 2019

97

P 1-6

Physically cross-Linked hydrogel with toughness, high stretchability,

biocompatibility, conductivity, and self-healability

Wenjing Ma 1, Guodong Fu1*

（1 School of Chemistry and Chemical Engineering, Southeast University, Jiangning District,

Nanjing, Jiangsu Province, 211189, China.）


Hydrogels are a class of chemically and/or physically cross-linked networks of

hydrophilic polymer chains. The special porous three-dimensional network structure

has enabled them to be widely applied in tissue engineering, waste treatment, and

electronic devices etc. However, conventional chemically cross-linked hydrogels are

often relatively weak and/or brittle, which limits hydrogels from wider applications.1

A novel physically cross-linked Xanthan gum (XG)/ Montmorillonite (MMT)/ poly

(acrylamide-co-acrylonitrile) Poly (AAm-co-AN) hydrogel is synthesized for

addressing the above drawbacks. The hydrogel could effectively dissipate energy and

obtain excellent fatigue-resistance and self-healing abilities. We expect that this

strategy can provide a new perspective for fabricating a unique multi-cross-linked

hydrogel with adjustable mechanical strength, as well as recovery, self-heal,

conductive, and fatigue-resistance properties, which would further widen the

application of hydrogel in modern high-tech fields.

Keywords: Hydrogel, Self-healing, Toughness, Stretchability, Biocompatibility

References:

1. K. Haraguchi and T. Takehisa, Advanced materials, 2002, 14, 1120-1124.

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June 14-17, 2019

98

P 1-7

Reverse Photochromic hydrogel with self-healing property for

potential rewritable display application

Mengmeng Kang1, Guodong Fu 1**********

（1 School of Chemistry and Chemical Engineering, Southeast University, Jiangning District,

Nanjing, Jiangsu Province, 211189, China.）


Reverse photochromic materials, which tuned by harmless visible light, could be

grant access to novel applications, such as anti-counterfeiting technologies, rewritable

displays, and optical data storage systems. Here, we developed a reverse

photochromic hydrogel based on 6-nitro-substitution spiropyran

(1-(beta-carboxyethyl)-3,3-dimethyl-6'-nitrospiro(indoline-2,2'-2H-benzopyran)) with

self-healing property, which could be colored by visible light and transform between

photochromic and fluorescence by treating with HCl and NH4OH. Here, the

self-healing hydrogel PVA-glycerol-borax was developed with abundant amount of

hydrogen bonds, dynamic B-O bonds and B-N bonds between borax and indole

nitrogen of spiropyran. Most importantly, the boron-nitrogen could enhance the

reverse photochromic phenomenon. The self-healing reverse photochromic hydrogel

has potential for using as rewritable displays with a long-span. This work provides a

method for reverse photochromic in the field of hydrogel, which will hopefully

expand applications of hydrogel in tunable rewrite displays.

Keywords: Self-healing, Reverse photochromism, Hydrogel, Rewritable display

References:

[1]Julialopez, D. Ruizmolina, J. Hernando, C.J.A.A.M. Roscini, Interfaces, 11 (2019)

11884-11892.

[2]. Shinmori, M. Takeuchi, S.J.J.o.t.C.S.P.T. Shinkai, 7 (1996) 1

This research was supported by the National Natural ScienceFoundation of China (Grant No. 326

9Z07040007D6).



June 14-17, 2019

99

P 1-8

CO2 sensitive self-supporting cellulose hydrogel as food spoilage

indicator

Xiao Hui Ge1, Lu Zheng1, Ren Liu1, Peng Lu1,2

（1.Institute of Light Industry and Food Engineering, Guangxi Key Laboratory of Clean Pulp and

Papermaking and Pollution Control, Guangxi University, Nanning, 530004, , China; 2.Jiangsu

Provincial Key Laboratory of Pulp and Paper Science and Technology, Nanjing Forestry

University, Nanjing, Jiangsu Province, 210037, China.）

A self-supporting cellulose hydrogel was prepared by gelation of the

TEMPO-oxidized bagasse cellulose nanofibrills (CNF) triggered by strong crosslink

between carboxylate groups on CNF and Zn2[object Object]. CNFs were fined down

to 200–500 nm after TEMPO process, with carboxylate contents 1.29 mmol/g. A

sound hydrogel was prepared at TOCNFs concentration of 3.0 wt% and zinc ions

concentration of 0.2mol/l. CO2 sensitive cellulose hydrogel indicator was prepared by

incorporating bromothymol blue and methyl red. For fresh-cut fruits, a clear color

change of cellulose hydrogel from dark green to orange yellow was observed during 7

days storage. Color changes correlated well with CO2 levels and micro-organisms

proliferation, which associated food spoilage. This bagasse derived CNFs hydrogel

can be fabricated to CO2 sensitive indicators for use in intelligent food packaging.

Keywords: Hydrogel; Cellulose Nanofibrills, CO2 sensitive, Spoilage indicators



June 14-17, 2019

100

P 1-9

Flexible semi-IPN network gel polymer electrolyte for supercapacitor

Mengxiao Wang, Chaowei Yin, Yu Chen, Ting Zhai, Yuanyuan Shi, Yueming Fan,

Gang Qin*, Jia Yang and Qiang Chen**

（School of Materials Science and Engineering, Henan Polytechnic University, Jiaozuo, 454003

China.）

*E-mail: [email protected] (G. Qin), [email protected] (Q. Chen).

Abstract: To meet the requirement of the flexible supercapacitors, the enhancement

of the mechanical properties of the gel polymer electrolyte (GPE) attracts more and

more attention. Here a novel PAM-PVP GPE has been developed with a

semi-interpenetrating (semi-IPN) structure, which results in the superior flexibility

and stretchability (elongation at break of 17.42 mm/mm), meantime, the ionic

conductivity reaches 0.138 S/cm. The PAM-PVP-H3PO4 GPE supercapacitor shows

outstanding cycle stability and can bear complex deformations including bending and

stretching. In addition, it possesses the stable electrochemical performances (65%

capacitance retention) at -20 ℃. The supercapacitor is promising for the application

in the flexible electronic devices under low temperature condition.

Keywords: Gel polymer electrolyte; Polyacrylamide; Semi-interpenetrating network;

Flexible supercapacitor; Low temperature resistance

References:

[1] Guo, X.; Bai, N.; Tian, Y.; Gai, L. J. Power Sources. 2018, 408 : 51-57.

[2] Wang, J.; Zhao, Z.; Muchakayala, R.; Song, S. J. Membr. Sci. 2018, 555:

280–289.

[3] Lv, P.; Li, Y.; Wu, Y.; Liu, G. ACS Appl. Mater. Interfaces. 2018, 10:

25384−25392.

[4] Na R,; Wang, X.; Lu, N.; Huo, G. Electrochim. Acta. 2018, 4:127.

[5] Tao, F.; Qin, L.; Wang, Z.; Pan, Q. ACS Appl. Mater. Interfaces. 2017, 9:

15541-15548.



June 14-17, 2019

101

P 1-10

All-in-one configured stretchable flexible supercapacitor with high

strength, excellent self-recovery and self-healing performances

Xianqiang Yu1, Xiangbin Sun1, Yu Li1, Gang Qin1, Jia Yang1††††††††††, Qiang Chen1*

（1 School of Materials Science and Engineering, Henan Polytechnic University, Jiaozuo, 454000,

China.）


The development of all-in-one configured supercapacitors with integrated high

performances (e.g. capacitance, strength, toughness, flexibility, self-recovery and

self-healing) is still a tremendous challenge. Herein, a novel, strong, tough multiple

hydrogen-bonds cross-linked polyvinyl alcohol/poly (N-hydroxyethyl acrylamide)

(PVA/PHEA) hydrogel electrolyte (HGE) were prepared. Moreover, the strong, tough,

recoverable and healable all-in-one configured PVA/PHEA/ polyaniline (PANI)

supercapacitor with the sandwich-like laminated structures was prepared by in situ

rapid polymerization of the aniline in high concentration, which can quickly deposit

to the upper and lower surfaces of the as-prepared HGE for avoiding the swelling of

the HGE. The multiple hydrogen bonds, rapid polymerization and deposition

endowed all-in-one configured PVA/PHEA/PANI supercapacitor with integrated

performances, where the PVA/PHEA/PANI film had excellent mechanical properties

(tensile strength of 1.07 MPa and tearing energy of 2492 J/m2). The all-in-one

configured supercapacitor exhibited high surface capacitance (98 mF/cm2), good

cycle stability and excellent flexibility. In addition, the supercapacitor exhibited

excellent capacitance retention during and after the deformations. In particular, it also

had high capacitance self-recovery and self-healing abilities. Thus, the current work

presents a novel and promising strategy to design the integrated high-performance

supercapacitors aiming for wearable electronics.

Keywords: Flexible supercapacitor, Multiple hydrogen bonds, High strength

References:

[1]. Hu XY.; Fan LD.; Qin G*.; Shen ZS.; Chen J.; Wang MX.; Yang J; Chen Q*, J.

Power Sources, 2019, 414, 201-209

[2]. Guo Y.; Zheng KQ; Wan PB*, Small, 2018, 14, 1704497


21504022).




June 14-17, 2019

102

P 1-11

Complex Deformation of Bilayer Hydrogels Based on Shape Memory

Hydrogel and Elastic Hydrogel

Qilin Wang1, Qiang Chen1,‡‡‡‡‡‡‡‡‡‡


China.）


Shape memory hydrogels with stimulus response properties have drawn much

attention in the field of bio-actuators and soft robots [1]. Herein, we presented a bilayer

structure hydrogel based on a shape memory hydrogel (S-gel) and an elastic hydrogel

(E-gel), which could exhibit complex deformation. Owing to their self-healing

properties, the two gels could be easily and toughly adhesive together to form the

bilayer hydrogel via hydrophobic interactions as heat treatment, the adhesion energy

could be up to 2000 J/m2. Various shapes of the bilayer gel could be achieved by

stretching, heating-cooling treatment, or combination of the above mentioned

methods. The bilayer hydrogels showed fast responsive properties, which could be

used as grippers.

Keywords: Shape memory hydrogels, Bilayer Hydrogels, Complex Deformation

References:

[1]. Wei, D.; Yang, J.; Zhu, L.; Chen, F.; Tang, Z.; Qin, G.; Chen, Q., Semicrystalline

Hydrophobically Associated Hydrogels with Integrated High Performances. ACS

Applied Materials & Interfaces 2018, 10 (3), 2946-2956.


21504022 and U1304516).



June 14-17, 2019

103

P 1-12

Hybrid Cross-linked Natural Protein Hydrogels with High Strength

Shaoping Lu1, Qiang Chen1,§§§§§§§§§§


China.）


Natural protein-based hydrogels possess excellent properties, however, most of

them are weak or brittle[1,2]. Herein, bovine serum albumins (BSA)-based gels with

dually cross-linked network structure (DC-BSA gels) were prepared. Compared to

BSA gels with single network structure, DC-BSA gels, consisting of covalent

dityrosine bonds and physical interactions caused by thermal denaturation, exhibited

high strength (35 MPa), fast recovery (stiffness recovery of 77% and toughness

recovery of 60% at room temperature for 3 min resting) and good fatigue resistance.

Moreover, DC-BSA gels also demonstrated excellent biocompatibility. We hope our

DC-BSA gels can be applied in the field of load-bearing soft tissues.

Keywords: Natural Protein Hydrogels, Dual Cross-linking, High Strength,

Self-Recovery, Biocompatibility

References:

[1]. Tang ZQ.; Chen Q*.; Chen F.; Zhu L.; Lu SP.; Ren BP.; Zhang YX.; Yang J.;

Zheng J* , Chem. Mater. 2019, 31,179

[2]. Chen, Q*., Zhu, L., Zhao, C., Wang, Q., & Zheng, J*. Advanced materials,

2013,25, 4171.


21504022 and U1304516).



June 14-17, 2019

104

P 1-13

Body-Temperature Responsive Ultrafast Shape Memory Hydrogel

Based on Natural Materials

Shurui Yang, Hongfang Liao, Chao Zhang, Qiqian Hu, Tao Wang,* and Zhen

Tong***********

School of Materials Science and Engineering, South China University of Technology, Guangzhou 510640, China

E-mail: [email protected], [email protected]

Shape memory hydrogels are a unique class of soft materials that have the

capacity to response to the external stimuli. They have demonstrated promising

applications in many fields, such as soft robots, smart drivers, artificial muscles and

so on. However, there are still many challenges for the existing shape memory

hydrogels, such as facile preparation methods, the fixation rate and response rate.

In this work, we prepared a hydrogel based on natural materials through a facile

method which could fix the temporary shape and recover to original shape quickly.

First of all, the gelatin hydrogel was prepared at low temperature due to the triple

helix structure. After that, the gelatin hydrogel was soaked in tannic acid solution for

hours. Finally, the hydrogel was soaked in hot water and the hydrogel was obtained.

As shown in Figure 1, the hydrogel can be fixed temporary shape in 25 ℃ water

for 1 s after immersing in 37 ℃ for 2 s and recover to original shape in 37 ℃ water

for 1 s. It is worth noting that this is a transition between room temperature and body

temperature. What’s more, there is a 100 % fixation and recovery for the hydrogel.

Because of its facial preparation, natural materials and body-temperature

response, it provides a possibility for shape memory hydrogel to be used in the

biomedical field.

Keywords: Hydrogel, Ultrafast shape memory, Body-temperature response

This research was supported by the NSFC (51573060 and 21427805) and the Pearl River S&T

Nova Program of Guangzhou (201710010146).




June 14-17, 2019

105

P 1-14

One-Step Synthesis of Healable Weak-Polyelectrolyte-Based

Hydrogels with High Mechanical Strength, Toughness, and Excellent

Self-Recovery

Xu Fang and Junqi Sun *

（State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin

University, Changchun 130012, P. R China）


Excellent self-recovery is critically important for soft materials such as hydrogels

and shape memory polymers. In this work, weak-polyelectrolyte-based hydrogels

with high mechanical strength, toughness, healability and excellent self-recovery are

fabricated by one-step polymerization of acrylic acid and poly(ethylene glycol)

methacrylate in the presence of oppositely charged branched polyethylenimine. The

synergy of electrostatic and hydrogen-bonding interactions and the in-situ formed

polyelectrolyte complex nanoparticles endow the hydrogels with a tensile strength of

~4.7 MPa, strain at break of ~1200% and toughness of ~32.6 MJ m-3. The hydrogels

can recover from a ~300% strain to their initial state within 10 min at room

temperature without any external assistance. Moreover, the hydrogels can heal from

physical cut at room temperature and exhibit a prominent shape-memory performance

with rapid shape recovery speed and high shape-fixing and shape-recovery ratios.

Keywords: Hydrogels, Mechanical properties, Shape memory, Supramolecular

chemistry

References:

[1]. Xu Fang and Junqi Sun *, ACS Macro Lett. 2019, 8, 500−505




June 14-17, 2019

106

P 1-15

Preparation and Properties of Nanocomposite Hydrogels

Cross-linked by Alumina Nanoparticles

Bo Xu†††††††††††

, Jiugang Yuan, Yuanyuan Yu, Ping Wang, Qiang Wang

Key Laboratory of Eco-Textile, Ministry of Education, College of Textile and

Clothing, Jiangnan University, Wuxi 214122, P. R. China


Hydrogels have attracted much attention in various areas due to their unique

physicochemical properties. However, the poor mechanical performance severely

limited their practical applications. It is well-known that the introduction of inorganic

nanomaterials into the polymer matrix as the cross-linking agents could significantly

enhance the toughness and strength of the resultant hydrogels [1]. Based on this

knowledge, a novel kind of nanocomposite hydrogels were prepared by in situ free

radical copolymerization of acrylic acid with other vinyl monomers such as N,

N-dimethylacrylamide (DMAA), 2-acrylamido-2-methylpropane sulfonic acid

(AMPS) and N-vinyl-2-pyrrolidone (NVP). The resultant hydrogels not only exhibit

outstanding mechanical properties, but also reveal some unique characteristics

including high transparency, swelling-resistance, self-healing and anti-fogging,

depending on their different components [2-4]. It is expected that this novel type of

hydrogel would have great promise for various applications, including soft robots,

artificial muscles, and optical devices.

Keywords: Hydrogels, High-strength, Alumina, Anti-fogging, Self-healing.

References:

[1]. Haraguchi K.; Takehisa T. Adv. Mater. 2002, 14, 1120.

[2]. Xu B.; Wang LL.; Liu YW.; Zhu HL.; Wang Q*. Matter. Lett. 2018,228, 104.

[3]. Xu B.; Liu YW.; Wang LL.; Ge XD.; Fu M.; Wang P.; Wang Q*. Polymers 2018,

10, 1025.

[4]. Xu B.; Yuan JG.; Wang P.; Wang Q*. Polymers 2018, 10, 1362.

This research was supported by the National Natural Science Foundation of Jiangsu Province

(Grant No. BK20180631).




June 14-17, 2019

107

P 1-16

Tough hydrogels with strong, fast and reversible underwater

adhesion

Ping RAO1, Taolin SUN2,3, Liang Chen1, Riku Takahashi1, Daniel R. King2,3,

Takayuki KUROKAWA2,3, Jian Ping GONG2, 3*

（1Graduate School of Life Science, Hokkaido University, Sapporo 001-0021, JAPAN, 2Faculty of

Advanced Life Science, Hokkaido University, Sapporo 001-0021, JAPAN, 3Global Institution for

Collaborative Research and Education (GI-CoRE), Hokkaido University)）


Hydrogels containing large amount of water are usually considered to show poor

underwater adhesion performance while it has potential application in diverse area

with wet environment including tissue engineering, bio-medical device, and even soft

robotics. Existing hydrogels showing poor underwater adhesion performance is

mainly because of limitation such as low robustness, weak interfacial bonding and

competition between adhesive interaction and interaction with water molecules. Here,

we propose a simple but effective method to design tough underwater adhesion of soft

gels. The designed hydrogels possess high robustness, strong physical interfacial

bonds, fast contact formation and reversible underwater adhesion on soft hydrogels.

The main ideas of this method are briefly described as follows. First of all, we

need tough materials to bear large deformation and high impact. Soft tough materials

are usually composed of stretchable polymer networks with sacrifice bonds. To design

reversible adhesives underwater, the sacrifice bonds should be recoverable such as

physical bonds (ionic bonds or hydrogen bonds). Second, surface channels are

introduced to prevent large drop of water from being trapped between the interfaces

resulting in reduction of real contact area. The water between the surfaces can be

drained out through these channels under normal pressure load. Third, the surface is

divided into many independent parts by the channels. The "lost" of one part will not

affect the others, to overcome all the discontinues parts, it requires frequent

re-initiation of the interface crack and the failure of the interface therefore occurs at

higher stress and more energy dissipation.

Keywords: Tough hydrogels, underwater adhesion, fast, reversible, trapped water




June 14-17, 2019

108

P 1-17

A Highly stretchable, tough and fast self-healing hydrogel based on

peptide-metal ion coordination

Ying Li1‡‡‡‡‡‡‡‡‡‡‡, Bin Xue2, Yi Cao2

（1Collaborative Innovation Center of Atmospheric Environment and Equipment Technology,

Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control, School of

Environmental Science and Engineering, Nanjing University of Information Science & Technology,

Nanjing 210044, China, 2Collaborative Innovation Center of Advanced Microstructures, National Laboratory of Solid

State Microstructure, and Department of Physics, Nanjing University, Nanjing 210093, China.）


Metal coordination bonds are widely used as the dynamic cross-linkers to

construct self-healing hydrogels. However, it remains challenging to independently

improve the toughness of metal coordinated hydrogels without affecting the

stretchability and self-healing properties, as all these features are directly correlated

with the dynamic properties of the same metal coordination bonds. In this work, using

histidine-Zn2+ binding as an example, we show that the coordination number (the

number of binding sites in each cross-linking ligand) is an important parameter for the

mechanical strength of the hydrogels. By increasing the coordination number of the

binding site, the mechanical strength of the hydrogels can be greatly improved

without sacrificing the stretchability and self-healing properties. By adjusting the

peptide and Zn2+ concentrations, the hydrogels can achieve a set of demanding

mechanical features, including the Young’s modulus of 7-123 kPa, the fracture strain

of 434-781%, the toughness of 630-1350 kJ m-3, and the self-healing time of ~1 h. We

anticipate the engineered hydrogels can find broad applications in a variety of

biomedical fields. Moreover, the concept of improving the mechanical strength of

metal coordinated hydrogels by tuning the coordination number may inspire the

design of other dynamically cross-linked hydrogels with further improved mechanical

performance.

Keywords: Gel, Self-healing, Metal chelation, Coordination number


21522402, 11674153, 81622033, 21774057 and 11804148).




June 14-17, 2019

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Asymmetric interpenetrating UCST polymer network as

multiple-responsive hydrogel actuator

Luqin Hua, Manqing Xie, Chuanzhuang Zhao*

（ Faculty of Material Science and Chemical Engineering, Ningbo University, Ningbo, Zhejiang

315211, China. ）

*E-mail: [email protected]. c n

Thermo-responsive hydrogels have attracted tremendous interest due to their

promising applications in artificial muscles, soft robotics, and flexible electronics.

However, most of these materials are based on polymers with lower critical solution

temperature (LCST), while those from upper critical solution temperature (UCST) are

rare. Herein, we report a multiple-responsive UCST hydrogel actuator based on the

complex of poly(acrylic acid) (PAA) and poly(acryl amide) (PAm). By applying an

asymmetric photo-polymerization process, a bilayer hydrogel is obtained, including a

layer of interpenetrating network of PAA/PAm and a layer of single network of PAm.

When cooled down below the UCST, the PAA/PAm layer is dehydrated due to the

hydrogen bonding of the two polymers while the PAm layer stays in swelling state,

driving the bilayer hydrogel to curl. Active motion can be realized in both aqueous

and oily milieu, thanks to the internal water exchange between the two layers.

Moreover, the hydrogel can be actuated with the stimuli of urea, a molecule that can

disrupt the hydrogen bonding between PAA and PAm. Interestingly, the bilayer

hydrogel actuator is also sensitive to the addition of salts (Na 2 SO 4 , NaCl, NaSCN),

and the behavior follows a typical Hofmeister series, rending itself with the

application of ion-sensitive actuator. Overall, the current study reveals a novel

strategy to design thermo-responsive actuator, which is to tailor the distribution of

hydrogen bond-former inside the polymer network.

Keywords: hydrogel actuator, interpenetrating network, UCST, hydrogen bond



June 14-17, 2019

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P 1-19

A shape memory hydrogel with editable permanent shape based on

orthogonal supramolecular interactions

Manqing Xie, Chen Wu, Chuanzhuang Zhao*

（ Faculty of Material Science and Chemical Engineering, Ningbo University, Ningbo, Zhejiang

315211, China. ）

*E-mail: [email protected]. cn

Shape memory hydrogels (SPHs) can maintain temporary shapes and return to

permanent shapes upon external stimuli, thus they have attracted tremendous attention

and shown promising applications in many fields. However, these SPHs cannot alter

their permanent shapes after being prepared, which restricts their reusability and their

applications. In this letter, we report the shape memory behavior of polyacrylamide

(PAAm)/alginate hydrogel cross-linked with the host-guest complex of α-cyclodextrin

and azobenzene. The hydrogel can memorize a temporary shape through coordination

with calcium ion and revert to its permanent shape in ethylenediaminetetraacetic acid

(EDTA) solution. Moreover, the permanent shape of the hydrogel, memorized by the

host-guest cross-linked PAAm network, can be erased and edited with the irradiation

of ultraviolet (UV) light, due to the photo-switchable binding strength of the

host-guest complex. Rheological study shows that the shape-erasing is conducted

through a stress relaxation process that accelerated by UV irradiation, during which

the constraints from the old permanent shape are released and the polymer network is

adapted to a new shape. In addition, the hydrogel exhibits interesting functions such

as spatial-selectivity and remote actuation, taking advantages of the unique character

of light stimuli. These novel properties of the material are attribute to the dynamic and

reversible nature of the two supramolecular interactions, host-guest interaction and

metal ion coordination, as well as their orthogonality.

Keywords: shape memory hydrogel; light-responsiveness; host-guest interaction;

metal ion coordination; viscoelasticity;



June 14-17, 2019

111

P 1-20

Color-Tunable Fluorescent Supramolecular Metallogels Constructed

by Lanthanide (Eu/Tb) Dependent Coordination Interaction

Long-Yue Yu, Xing-Dong Xu§§§§§§§§§§§

（Key Laboratory of Special Functional Aggregated Materials, Ministry of Education, National

Engineering Research Center for Colloidal Materials, Shandong University, Jinan 250100,

Shandong, China）

* E-mail: [email protected]

Supramolecular self-assembly formation of soft materials such as hydrogels have

attracted the attention of researchers across various disciplines due to the rich

potential they can provide within different fields of applications.1 New fluorochromic

soft materials that reversibly change their emission properties in response to their

environment are of interest for the development of sensors and light-emitting

materials.2 A new design of Lanthanide-containing polymer hydrogels showing

tunable fluorochromic properties and fast self-healing is reported. This study supplies

a convenient approach toward the construction of structure-tunable fluorescent

supramolecular materials with different colors.

Figure 1. Schematic representation of supramolecular structure (left) and the

emission spectra with different ratio of Eu(III) and Tb(III).

Keywords: Hydrogel, Self-assembly, Luminescent material, Coordination chemistry

References:

[1]. X.-D. Xu, X. Li, H. Chen, Q. Qu, L. Zhao, H. Ågren, Y. Zhao, Small 2015, 11,

5901.

[2]. G. Weng, S. Thanneeru, J. He, Adv. Mater. 2018, 30, 1706526.


the Natural Science Foundation of Shandong Province (ZR2016BQ11).



June 14-17, 2019

112

P 1-21

Tough Lignin Bonded Hydrogels with Tunable Mechanical Properties

Xuelian Wang1, Xiangyu You1*, Huijie Zhang 1*, Xinping Li1

（1Department of Bioresources Chemical and Materials Engineering,

Shaanxi University of Science&Technology, Weiyang District, Xi'an, Shaanxi, 710021, China）


Hydrogels are solid jelly-like polymeric materials containing large amounts of

water due to their chemical and/or physical bonded frameworks with excellent

hydrophilic property. Hydrogels derived from lignin, an abundant highly branched

biopolymer in plants, had attracted much attention due to its naturally possessed

biocompatibility and biodegradability. However, the application of conventional

lignin hydrogels was limited by their poor mechanical properties.In this study, a series

of tough hydrogels were synthesized with the attendance of acetic acid lignins, which

basically contained hydroxyl groups, acetyl groups and C9 structure with

hydrophobicity. Based on such structural characteristics, lignin was expected to

establishstrong physical interactions, such as hydrogen bond and hydrophobic

associations, with synthetic polymer chains in strategy design. Specifically,

dimethylacrylamide (DMAAm) was first polymerized in water to form hydrogel

precursors. Subsequently, acetic acid lignin solutions were then mixed with the

resultant hydrogel precursors. The final gelation was finished through solvent

exchange process. Herein, the morphological of the hydrogel and mechanical

properties were systemically investigated. Interestingly, the tensile strength and strain

largely improved up to 2.5 MPa and 1200 %, respectively, which is 20 times higher

than those performance among conventional lignin hydrogels. In addition, the fracture

energy achieved more than 5000 J/m2 on the same scale of nature rubber.

Keywords:Lignin, Hydrogel, Physical interactions

References:

[1].Sun J Y , Zhao X , Illeperuma W R K , et al. Highly stretchable and tough

hydrogels[J]. Nature, 489(7414).




June 14-17, 2019

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Reinforcement of gelatin hydrogel by heat-induced phase separation

Chunlin Liu1, HuijieZhang2*, XuechuanWang2*

（1School of Chemistry& Chemical Engineering, Shaanxi University of Science & Technology,

Xian 710021,2 College of Bioresources Chemical and Materials Engineering, Shaanxi University

of Science & Technology, Xian 710021, China;.）


Most protein-based hydrogels are mechanically weak. Usually, the strength of

these hydeogelsis enhanced by chemical modification or compounding with synthetic

or other natural polymers. In this work, we focus on adjusting mechanical properties

through self-aggregation of protein chains and realized highly tunable mechanical

properties of a gelatin hydrogel by simple heat-treatment.Specifically, the reported

ductile (NH4)2SO4/ gelatin hydrogel[1] was used as initial gel. By heating, the helix

junctions were destroyed and gelatin chains were supposed to aggregate and fold to

form more and denser hydrophobic aggregation due to the salt-out effect. The resulted

gel became opaque indicating phase-separation.From SAXS analysis, it was found

that upon heating the structure size increased and the aggregated part became firstly

denser than looser. Correspondingly, gel became stronger and then softer by both

increasing heating temperature and heating time. The strongest gel exhibited superior

mechanical properties of higher modulus (7.46 MPa) and fracture energy (2160 J/m2)

to thatof the initial gel (0.99MPa, 1000 J/m2), and better recovery property. The

further enhanced mechanical property would provide the gel with more potential

application in engineering area.

Keywords:Hydrogel, Gelatin, Self-aggregation,Phase separation

References:

[1].Qingyan He, Yan Huang,*Shaoyun Wang*. Adv. Funct. Mater.2018, 28, 1705069



June 14-17, 2019

114

P 1-23

Dual physically cross-linked double network hydrogel with high

toughness and self-healing capability

Yanjie Wang, Sijun Liu************

（Advanced Rheology Institute, Department of Polymer Science and Engineering,

Shanghai Jiao Tong University, Shanghai 200240, P. R. China）


Due to the irreversible fracture of covalent bonds and cytotoxicity of chemical

cross-linking agents, traditional chemically cross-linked double network (DN)

hydrogels generally exhibit low fatigue resistance and poor biocompatibility, which

greatly limits the application of stretchable hydrogels in biological tissue engineering.

Here, based on the design of dual physical network (ionic association and

hydrophobic association), we successfully prepared the gellan gum/hydrophobically

modified polyacrylamide (GG/HPAAm) DN hydrogel with remarkable mechanical

properties: stress at break of ~800 kPa, strain at break of ~1500%, elastic modulus of

~300 kPa. Because of the reversibility of physical network fracture, the dual

physically cross-linked GG/HPAAm hydrogels exhibit excellent self-recovery at

room temperature (recovery efficiency up to 50%), and the recovery efficiency can be

further improved after the deformed and relaxed hydrogel sample underwent a cycle

of heating and cooling due to the thermoreversible gelation of GG. More importantly,

the thermoreversible gelation property also endows the self-healing capability of the

GG/HPAAm hydrogel. Therefore, this study provides a new strategy for the

preparation of biocompatible hydrogels with high mechanical properties, remarkable

recovery and self-healing capability, which expands the application of hydrogels in

the field of tissue engineering.

Keywords: Hydrogel, Dual physically cross-linked, Self-recovery, Self-healing,

Biocompatibility

References:

[1]. Chen Q.; Zhu L.; Chen H.; Yan HL.; Huang LN.; Yang J.; Zheng J*, Adv. Funct.

Mater. 2015, 25,1598-1607




June 14-17, 2019

115

P 1-24

Control of ice crystal growth and its effect on porous structure

of chitosan cryogels

Haiyan Zhang, Chunjie Liu, Liang Chen*, Bin Dai*

（Key Laboratory for Green Processing of Chemical Engineering of the Xinjiang Bingtuan,

School of Chemistry and Chemical Engineering, Shihezi University, Shihezi 832000, China）

*E-mail: [email protected] (L. Chen), [email protected] (B. Dai)

We presented an improved preparation method to generate cryogels with

controllable pore size. Itincluded 5 stages: pre-cooling, pre-crystallization, crystal

growth, freezing, and thawing (PPCFT); crystalgrowth was the key step. Chitosan (CS)

cryogels with uniform and honeycomb-like structures were preparedwith the method,

and then the properties of these cryogels were studied. The results demonstratedthat

the mean pore diameters of CS cryogels were successfully controlled in a wide range

(approximately60–240 lm, by scanning electron microscope) by simply varying the

temperature and time of crystalgrowth. The crystal growth law of this process was

described by an empirical equation based on the classicaltheory for Ostwald ripening

by Lifshitz, Slyozov, and Wagner (LSW). Furthermore, the

hydrodynamicsperformance (permeability and column efficiency) of CS cryogel

columns clearly varied with crystalgrowth conditions, while both the accessible

porosity and water absorption ratio remained at a highlevel.

Keywords:Crystal growth, Cryogels, Morphology, Pore size, Chitosan

References:

[1].Zhang HY.; Liu CJ.; Chen, L*.; Dai, B*,Controlof ice crystal growth and its effect

on porous structure ofchitosan cryogels. Chem. Eng. Sci. 2019, 201, 50.

This research was supported by the National Natural Science Foundation of China

(Grant No. 21206094).



June 14-17, 2019

116

P 1-25

In-situ forming thermosensitive polyurethanes-based hydrogel

crosslinked by Diels-Alder reaction for 3D cell culture

Yan Jun Wang, Zhen Yan Bai, Zhen Li, Jie Hua Li, Feng Luo††††††††††††, Hong Tan

（State Key Laboratory of Polymer Materials Engineering, College of Polymer Science and

Engineering, Sichuan University, Chengdu 610064, China.）


Injectable hydrogels crosslinked physically have attracted much attention in

scaffolds biomedical field [1]. However, traditional hydrogels with weak strength and

uncontrollable gelling kinetics by injecting in vivo, which limit their applications [2].

A novel furyl-modified polyurethanes hydrogel is synthesized for developing

injectable degradable hydrogel using crosslinker maleimide-terminated PEG. In the

polyurethane, PEG shows good hydrophilicity and the functional modification of

chain extender endows the hydrogel with expected injectable gelling. The mechanical

strength and gelling time of crosslinked polyurethanes hydrogel could be improved by

adjusting the molar ratio of furyl to maleimide. The hydrogel obtains comprehensive

mechanical properties and favorable injectability. The work proposes a novel strategy

to constructing self-assembly polyurethane micelles before spontaneous gelation. This

injectable and biodegradable crosslinking hydrogel holds great potential application

for 3D cell culture and tisse repair.

Keywords: Biodegradable, Injectable hydrogel, Diels-Alder reaction, Cell

encapsulation, Polyurethanes.

References:

[1]. Smith LJ.; Taimoory SM.; Tam RY.; Aeg B.; Binth MN.; Trant JF*,

Biomacromolecules. 2018, 19, 926.

[2] Yang X.; Liu G.; Peng L.; Guo J.; Tao L.; Yuan J.; Lina Z*, Adv. Funct. Mater.

2017, 27,1703174


51873117, 51673126, 51733005), the National Science Foundation For Distinguished Yong

Scholars of China (51425305).



June 14-17, 2019

117

P 1-26

Shape memory hydrogel based on sodium alginate crosslinked by

double networks

Xudong He1*, Hongmei Chen1, Ping Hu1

（1 College of Chemistry and Materials Science , Sichuan Normal University,

Chengdu 610066, P. R. China）


Sodium alginate has attracted wide attentions for its excellent biocompatibility

and biodegradability.[2-3] Smart hydrogels based on sodium alginate can be applied in

the fields of gene delivery, tissue engineering, drug controlled release, wearable soft

materials, etc. But the single-function nature, slowly response and low strength of

traditional hydrogels restricted its applications. A dual networks hydrogel based on

sodium alginate crosslinked by glutaraldehyde and calcium ion are prepared.[1]Tensile

testing showed that the mechanical strength of this hydrogel can reach 6.2 MPa. This

hydrogel showed excellent water-induced shape memory property by introducing

cellulose into the dual networks, and the shape fixing ratio and recovery ratio are

nearly 100%. For its excellent performance, this hydrogel can be applied as

cardiovascular stents, robotic muscles and wearable soft materials.[4]

Keywords: Sodium alginate hydrogels, Dual crosslinked networks, Water-induced

shape memory property.

References:

[1] Q. Chen, H. Chen, L. Zhu, J. Zheng, Fundamentals of double network hydrogels,

Journal of Materials Chemistry B 3 (2015) 3654-3676.

[2] Y. Vijaya, S.R. Popuri, A.S. Reddy, A. Krishnaiah, Synthesis and characterization

of glutaraldehyde-crosslinked calcium alginate for fluoride removal from aqueous

solutions, Journal of Applied Polymer Science 120 (2011) 3443-3452.

[3] H. Hecht, S. Srebnik, Structural Characterization of Sodium Alginate and Calcium

Alginate, Biomacromolecules 17 (2016) 2160-2167.

[4] Jiyu Yang, Yanan Zheng, Linjuan Sheng, Hongmei Chen,* Lijuan Zhao, Wenhao

Yu, Ke-Qing Zhao,and Ping Hu,Water Induced Shape Memory and Healing Effects

by IntroducingCarboxymethyl Cellulose Sodium into Poly(vinyl alcohol),Ind. Eng.

Chem. Res. 2018, 57, 15046−15053



June 14-17, 2019

118

P 1-27

Highly adhesive and stretchable photothermal hydrogels for

preventing postoperative recurrence of cancer

Wenwen Jiang, Rui Zhao, Liang Hu‡‡‡‡‡‡‡‡‡‡‡‡

（State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and

Protection, Soochow University, Suzhou 215123, China.）


Prevention of postoperative tumor recurrence is crucial to improve the survival

rate of patients.1 To address this, in-situ locating a photothermal hydrogel patch to the

resected tumor site is a simple, rapid and safe strategy. This required photothermal

hydrogels with high adhesion and stretchability, yet it is still a great challenge.2 In this

work, we constructed a poly(acrylamide-co-N-(3-aminopropyl)methacrylamide)

(p(AAm-co-APMA)) hydrogel that was crosslinked by polydopamine nanoparticles

(PDA NPs). The hydrogel showed high adhesive strength to a variety of substrates

(e.g., ~115 kPa to the porcine skin), stretchability (~3700%) and photothermal

property. These merits can be ascribed to the use of PDA NPs as crosslinkers and

numerous physical interactions (π-π interactions as well as the hydrogen bonds) in the

system. Finally, we showed that, upon exposure to 808 nm light within 3 min, the

p(AAm-co-APMA) photothermal hydrogel patch absorbed light and converted to

thermal, thereby effectively preventing postoperative recurrence of the breast cancer

in mice.

Keywords: Hydrogel, Adhesive, Stretchable, Photothermal therapy

References:

[1]. Mahvi, DA.; Liu, R.; Grinstaff, MW.; Colson, YL.; Raut, CP., Ca-Cancer J. Clin.

2018, 68, 488

[2]. Han, L.; Lu, X.; Liu, KZ.; Wang, KF.; Fang, LM.; Weng, LT.; Zhang, HP.; Tang,

YH.; Ren, FZ.; Zhao, CC.; Sun, GX.; Liang, R.; Li, ZJ., ACS Nano 2017, 11, 2561


51873137).



June 14-17, 2019

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P 1-28

Sulfonated MXene Nanocomposite Hydrogels for Self-healing,

Adhesive and Conductive Properties

Ze Peng Deng1, Yang He1, Yi Ping Zhao1, Li Chen1,2§§§§§§§§§§§§

（1 School of Materials Science and Engineering,Tianjin Polytechnic University, Tianjin, 300387.2

School of Materials Science and Engineering, Tianjin University of Technology, Tianjin, 300384）


Currently, self-healing, adhesive and conductive hydrogels have been

highlighted their potential in wearable electronic devices, soft robotics and tissue

engineering. Herein, we demonstrated a facile one-step synthesis method of

nanocomposite hydrogels incorporating sulfonated MXene (MXene-SO3H) by

ionotropic gelation of chondroitin sulfate (CS) and poly (methyl chloride quarternized

N, N-dimethylamino ethylacrylate) (PDMAEA-Q). Owing to the abundant

electrostatic interaction between the multivalent anionic CS and cationic PDMAEA-Q,

the hydrogel matrix revealed a rapid and reversible self-healing property (within 2s)

without any assistance of external stimuli. The nanocomposite hydrogels displayed

robust adhesiveness ascribed to the presence of glycosaminoglycan ingredients from

the CS, which can be adhered directly on porcine skin with excellent biocompatibility.

Meanwhile, the stable dispersive 2D MXene-SO3H nanosheets were well-integrated

with the polymer network, which endowed the hydrogels conductivity. The

fascinating physical properties of the MXene facilitated high sensitivity to

deformation, near-infrared light and humidity in the nanocomposite hydrogels.

Consequently, the combination of these properties enables the nanocomposite

hydrogels to act as biosensors in wearable, wireless, and soft electronics for

human-machine interfaces, human activity monitoring, personal healthcare diagnosis,

etc.

Keywords: Nanocomposite hydrogel, MXene, Self-healing, Conductivity, Sensor

References:

[1]. Sun TL.; Kurokawa T.; Kuroda S.; Ihsan AB.; Gong JP., Adv. Funct. Mater.

2013, 12(10): 932

This research was supported by the Science and Technology Plans of Tianjin (18PTSYJC00180),

Program for Innovative Team in University of Ministry of China (IRT-17R80).



June 14-17, 2019

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P 1-29

Research on Gel Analyzer Based on Image Processing

Xiaojuan Ren, Rui Wang, Saqib Siddique

（College of Petroleum Engineering, Xi’an Shiyou University,Xi’an 710065）


As a chemical plugging and plugging agent, gel plays an important role in crude

oil recovery and oil and gas recovery. The mechanical properties of gel are of great

importance to the quality of oil well plugging. At present, there is no system for

detecting the mechanical properties of Water Plugging Gel in the market, and most of

the products on the market rely on foreign imports, and the price is more expensive.

Therefore, through full investigation and research, a set of high precision and high

reliability gel mechanical properties measurement system is developed by using

digital image processing technology in order to solve the problem of low detection

precision in the process of gel mechanical properties detection.

The entire analysis system is composed of two major modules: displacement

pump pressurization unit and machine vision unit. The software system is based on

the modular programming language. The core of the analysis of gel mechanical

properties is image processing. For the basic characteristics of capillary gel images,

the gel image is first targeted for preprocessing and then a novel adaptive threshold

segmentation algorithm is proposed to obtain a more accurate capillary gel concave

surface. Finally, the gel concave surface is completely extracted to obtain the position

parameters of the gel concave surface and then combined with fluid mechanics theory

to calculate the mechanical properties of the oil field production requirements. All

data and images in the experiment will be stored in the database for the convenience

of testers. In order to improve the accuracy of the instrument, this paper analyzes the

most important mechanical properties of the gel: the possible error sources in the

viscosity measurement process and then the machine vision unit program is improved

to make the instrument more mature and the measurement system has a higher degree

of automation.

After completing the design and construction of the smart gel analysis system,

five different concentrations of gel samples were selected and compared with the

results of a rotary rheometer. The tests showed that for the five gel samples, two

measurements were performed. The measurement error between the methods is

relatively small and remains within 5%. It is proved that the measurement system of

gel mechanical properties studied in this paper has certain feasibility and reliability.

Keywords: Gel, Digital image processing, Measurement system design

References: [1].Xiaojuan Ren, Xinwei Gao, Xiangrong Luo,etc.A device and method for evaluating the performance of gel: China, ZL201611189905.3 [P]. 2017-11-14. [2].Yunzhou Ye. Research on Gel Analyzer Based on Image Processing[D]. Xi’an Shiyou University,2018.




June 14-17, 2019

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P 1-30

Preparation of keratin-based polymer hydrogel with double

sensitivity for drug releasing

Yujuan Wei, Rong-Min Wang*************, Juhua Guo, Zejun Wang, Yufeng He

（Key Lab. Eco-Environment-Related Polymer Materials of Ministry of Education, Institute of

Polymer, Northwest Normal University, Lanzhou 730070, China.）


In past decades, the intelligent polymers had been paid extensive attention as

stimulus-responsive polymer materials can transport drugs or bioactive substances

effectively. Keratin, being extracted from feathers, has good biocompatibility,

degradability and low immunity. And it can be used in all aspects of biomedicine[1,2].

In this paper, feather keratin (FK) was used as biopolymer substrate, itaconic acid (IA)

and N-isopropylacrylamide, as non-toxic and stable units, were selected as pH

sensitive monomers and temperature-sensitive monomers. The keratin-based polymer

hydrogel with double sensitivity were prepared in the presence of crosslinking agent.

Firstly, poly(N-isopropylacrylamide) was combined with FK. Then, IA was in-situ

polymerized, which afforded FK-based double sensitive polymer hydrogel with

interpenetrating network structure. In order to evaluate the suitability of FK-based

hydrogels as biomaterials, we measured the swelling rate of the double-sensitive

hydrogels in different simulated biological solutions at body temperature. The results

showed that the FK-based hydrogels has higher swelling rate and good swelling

performance in water, D-Glu solution and saline solution. Using small molecular and

macromolecular drug, its release behaviors were studied in different temperatures and

pH medium. The result indicated that the drugs controlled release from hydrogels

could be realized by adjusting temperature and pH value.

Keywords: Biopolymer gel, Feather keratin, Double sensitive, Drug release

References:

[1] Yin XC; Li FY; He YF., Wang Y; Wang RM, Biomater. Sci., 2013, 1(5), 528.

[2] Shavandi A; Silva TH; Bekhit AA; Bekhit AEDA, Biomateri Sci., 2017, 5(9),

1699.


21364012, 21865030).



June 14-17, 2019

122

P 1-31

Facile preparation and enhanced stretchableperformance of

self-assembled polyelectrolytes-based composite hydrogels

Ran Wang1,2,Tifeng Jiao1,2*, Lexin Zhang2,Qiuming Peng1,*

(1State Key Laboratory of Metastable Materials Science and Technology, Yanshan University,

Qinhuangdao 066004, P. R. China; 2Hebei Key Laboratory of Applied Chemistry, School of

Environmental and Chemical Engineering, Yanshan University, Qinhuangdao 066004, P. R.

China.）

*E-mail: [email protected](T. Jiao);[email protected] (Q. Peng).

Hydrogels attract a great attention due to their soft and moist properties, but the

preparation of hydrogels with good mechanical properties requires further

investigation. In this study, we reported the preparation of polyelectrolytes-based

polyion complexes (PIC) hydrogel polymerized sequentially via two monomers with



June 14-17, 2019

123

cationic and anionic groups and subsequent several composite hydrogels. The PIC

hydrogel was doped with graphene oxide (GO), carbon nanotubes (CNTs) and layered

double hydrotalcites (LDHs) with different weight ratios, respectively. The structures

and changes of mechanical properties of the formed composite hydrogels were

investigated by SEM, BET, nanoindentation and strain-stress tests. We also studied

the dye adsorption capacities of the prepared hydrogels for MB and RhB, and the

doped composite hydrogels showed different adsorption properties compared to the

original PIC hydrogel. Present work demonstrated new clue to prepare composite

hydrogel materials with enhanced mechanical properties and promoted wide

applications.

Keywords: Composite hydrogel, Component doping, Mechanical properties,

Adsorption

References:

[1] Hou CL.; Jiao TF.; Xing RR.; Chen Y.; Zhou JX.; Zhang LX, J. Taiwan Inst.

Chem. E. 2017, 78, 118-126.

[2] Guo R.; Jiao TF.; Li RF.; Chen Y.; Guo WC.; Zhang LX.; Zhou JX.; Zhang QR.;

Peng QM, ACS Sustain. Chem. Eng. 2018, 6, 1279-1288.

[3] Zhu K.; Jiao TF.; Zhang LX.; Xing RR.; Guo R.; Zhou JX.; Hou CL.; Zhang QR.;

Peng QM.; Li X, Sci. Adv. Mater. 2016, 8, 1400-1407.

-------------------------------------------

This research was supported by the National Natural ScienceFoundation of China (Grant No.

21872119), Support Program for the Top Young Talents of Hebei Province, and Research Program

of the College Science & Technology of Hebei Province (No. ZD2018091).



June 14-17, 2019

124

P 1-32

Tough, antibacterial and antifouling double network hydrogels based

on hybrid ionic-covalent crosslinking*

Zhang Jing * , Shen Biao, Chen Lingdong, Feng Jie

College of Materials Science and Engineering, Zhejiang University of Technology, Hangzhou,

Zhejiang, 310014, P. R. China

* Email：[email protected]

Due to their self-healing ability and fatigue resistance, hybrid ionically-covalently

crosslinked double-network (DN) hydrogels have received widely attention 1 . By a

simple “one-pot” method, a novel kind of hybrid ionic-covalent

chitosan/polysulfobetaine (CS/PSBMA) double-network hydrogels was synthesized.

The obtained DN hydrogels exhibit high tensile strength (2.0 MPa), strong elastic

modulus (0.5 MPa), fast self-recovery ability, and excellent antifatigue capacity.

Notably, the hydrogels still remain mechanical strength and toughness after soaking in

water for 24 h. More excitingly is that the hybrid DN hydrogels have excellent

antibacterial, antifouling properties and biocompatibility. We believe that the hybrid

DN hydrogels will find potential applications in biomedical applications, such as

artificial cartilage.

Figure 1. (A) Preparation of hybrid ionic-covalent CS/PSBMA DN gels using the “one-pot”

method. (B) H&E staining images of the CS/PSBMA DN hydrogel implanted subcutaneously in

mice for 28 days.

Keywords: Double network hydrogel, High mechanical properties, Biocompatibility,

Antibacterial, Antifouling

References:

[1]. Yang Y, Wang X, Yang F, et al. Advanced Materials, 2018:1707071.

-------------------------------------------

This work was funded by Zhejiang Provincial Natural Science Foundation of China

(LY17E030005) and the National Natural Science Foundation of China (21404091).



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P 1-33

Double cross-linking the second network of DN hydrogel for tough

sensitive strain and pressure sensors

Lin Jie Zhou1*, Jun Fu1

（1Ningbo Institute of Materials Technology & Engineering, Chinese Academy of Sciences, 1219

Zhongguan West Road, Ningbo 315201, China.）


Hydrogels, characterized for high water content and three-dimension network,

have attracted much attention owing to their broad potential applications as

cartilages1-2, scaffolds3, actuators4-6 and soft sensors7-8, etc. Specifically, conductive

hydrogels, as soft, flexible and biocompatible conductor are promising materials for

electronic skins9 or implantable sensors10 to detect human physiological and physical

signals. Based on the dynamic metal-coordination, here, we report a

κ-carrageen/P(AAm-co AAc) DN hydrogel based on biopolymer κ-carrageen with

outstanding mechanical properties. Fe3+ ions were used to further crosslink the second

network by forming coordination complex with carboxyl groups in AAc. Hydrogels

with different content of coordination complex exhibit excellent mechanical

performance with fracture tensile stress of 0.47~1.52 MPa, fracture strain of

160~2800%. The hydrogels show good electrical fatigue resistance and high

sensitivity of 2.8 at 500% strain which performance well in strain and pressure sensors

for practical applications.

Keywords: Hydrogel, Toughness, Conductivity, Sensor

References:

1. Adams, M. A.; Kerin, A. J.; Wisnom, M. R., Sustained loading increases the

compressive strength of articular cartilage. Connective Tissue Research 1998, 39 (4),

245-256.

2. Naficy, S.; Brown, H. R.; Razal, J. M.; Spinks, G. M.; Whitten, P. G.,

ChemInform Abstract: Progress Toward Robust Polymer Hydrogels. Cheminform



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126

2015, 43 (2), 1007-1025.

3. Hoffman, A. S., Hydrogels for biomedical applications. Annals of the New York

Academy of Sciences 2012, 64 (1), 18-23.

4. Maeda, S.; Hara, Y.; Sakai, T.; Yoshida, R.; Hashimoto, S., Self-Walking Gel.

Advanced materials 2007, 19 (21), 3480-3484.

5. Yao, C.; Liu, Z.; Yang, C.; Wang, W.; Ju, X. J.; Xie, R.; Chu, L. Y.,

Poly(N‐isopropylacrylamide)‐Clay Nanocomposite Hydrogels with Responsive

Bending Property as Temperature‐Controlled Manipulators. Advanced Functional

Materials 2015, 25 (20), 2980-2991.

6. Shin, M. K.; Spinks, G. M.; Shin, S. R.; Kim, S. I.; Kim, S. J., Nanocomposite

Hydrogel with High Toughness for Bioactuators. Advanced materials 2009, 21 (17),

1712-1715.

7. Son, D.; Bao, Z., Nanomaterials in Skin-Inspired Electronics: Toward Soft and

Robust Skin-like Electronic Nanosystems. ACS nano 2018, 12 (12), 11731-11739.

8. Wang, L.; Gao, G.; Zhou, Y.; Xu, T.; Chen, J.; Wang, R.; Zhang, R.; Fu, J., Tough,

Adhesive, Self-Healable, and Transparent Ionically Conductive Zwitterionic

Nanocomposite Hydrogels as Skin Strain Sensors. ACS Applied Materials &

Interfaces 2019, 11 (3), 3506-3515.

9. Yang, T.; Wang, W.; Zhang, H.; Li, X.; Shi, J.; He, Y.; Zheng, Q.-s.; Li, Z.; Zhu,

H., Tactile Sensing System Based on Arrays of Graphene Woven Microfabrics:

Electromechanical Behavior and Electronic Skin Application. ACS nano 2015, 9 (11),

10867-10875.

10. Han, L.; Lu, X.; Wang, M.; Gan, D.; Deng, W.; Wang, K.; Fang, L.; Liu, K.; Chan,

C. W.; Tang, Y.; Weng, L.-T.; Yuan, H., A Mussel-Inspired Conductive, Self-Adhesive,

and Self-Healable Tough Hydrogel as Cell Stimulators and Implantable Bioelectronics.

Small 2017, 13 (2), 1601916.



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P 1-34

Synthesis and swelling properties of superporous anionic hydrogel

based polyvinyl alcohol-formaldehyde sponges

Jiuduo Xu, Xu Yang, Di Sha, Kai Shi, Baolong Wang, Xiangling Ji*

（Key State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied

Chemistry, Chinese Academy of Sciences, Changchun 130022, China）


Superporous hydrogels (SPHS) are developed from superabsorbent

polymers(SAPs) with swell faster, within mimutes, to the equilibrium swollen and

faster response to environmental change. A series of superporous anionic hydrogels

(SPAHs) containing sodium carboxylate groups were synthesized by acetalization

reaction used of aldehyde crossing with modified poly(vinyl alcohol-co-vinyl acetate).

Through control the concentration of reactants and surfactants and the stirring rate

systematically the interconnected open cellular structure can be obtainted in the

superporous hydrogels. FITR and 13C NMR demonstrated that (SPAHs) was

successfully synthesized via acetalization reaction and carboxyl contents can be

controlled by changing experimental conditions. A typical interconnected open

cellular structure was observed by scanning electron microscopy. The as-prepared

hydrogels exhibited a mean pore sizes ranging from 60 to 100μm, and an

interconnected pores having a porosity of around 90%. The PVF-based hydrogel

possessed excellent mechanical property in dry state and swelling capacity in wet

state. Notably, the SPAHs can absorb deionized water as high as 130 g g-1 within 90 s

and can also absorb saline solution at a maximum capacity of 38 g g-1 in 120 s. The

sponges were characterized by their dynamic swelling behavior in solvent, ie the mass

of water absorbed by a sample of sponges was measured vs time and the kinetics of

the adsorption process was studied. And then the appropriate model was used

expected to possess accurate predictive ability for the diffusion coefficient of solute in

hydrogel, which will be widely used in the biomedical, chromatographic separation,

absorber, etc. field.

Keywords: PVA, Superporous anionic hydrogel, Swelling properties,

Diffusion-relaxation model

References:

[1]. Rosa F, Bordado J, Casquilho M. Polymer, 2002, 43(1): 63-70.



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P 1-35

Biotribology behavior of UHMWPE grafted with PVA/HA composite

hydrogel as artificial cartilage materials

Kai Chen, Siyu Liu, Fengyan Wang

School of Materials Science and Engineering, China University of Mining and Technology,

Xuzhou 221116, China

[email protected]

Abstract: The human body joint motion is very complicated, which mainly includes

sliding, swing, rotation. Therefore, cartilage covering the joint surface bears the

repeated friction which is caused by the different movements during the whole life. So

sliding, swing and torsion friction behavior of hydrogels need to be researched as

synthetic articular cartilage. In this paper, PVA/HA composite hydrogel is cross-linked

on the UHMWPE surface through chemical grafting and freezing-thawing method.

Biotribology behavior and fluid load support are researched. The results show that

swing and torsion friction coefficients are negligibly small, while sliding friction

coefficient is largest. There is a negative linear relationship between fluid load support

and friction coefficient. Fluid load supports are relative high under swing and torsion

friction, so the swing and torsion friction coefficients are relative low. Hydrogel can

be replenished by re-swelling to sustain the fluid pressurization during friction under

lubrication condition. Both fluid load support and biphasic lubrication due to its

porous structure with large amount of water contribute to the low friction coefficient.

Keywords: PVA/HA composite hydrogel; fluid load support; biotribology; lubrication

Fig 1 Relationship of friction coefficient Fig 2 Relationship of friction coefficient

and load under different movement modes and fluid load support under different movement modes



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Fig 3 Relationship of friction coefficient Fig 4 Relationship of friction coefficient

and speed under different movement modes and fluid load support under different movement modes

Acknowledgements

This research is supported by National Natural Science Foundation of China (Grant

No. 51705517, 51875564), Natural Science Foundation of Jiangsu Province (Grant

No. BK20160257), National Key Research and Development Program of China

(Grant No. 2016YFC1101803).



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P 1-36

Internal Damage Evolution in Double-Network Hydrogels Studied by

Microelectrode Technique

Honglei Guo1,2, Wei Hong3,2,4, Takayuki Kurokawa1,2, Takahiro Matsuda5, Zi Liang

Wu1,6, Tasuku Nakajima1,2,7, Taolin Sun1,2,8, Ping Rao5, Jian Ping Gong*1,2,7

(1Faculty of Advanced Life Science, 2Soft Matter GI-CoRE, Hokkaido University, Sapporo, Japan;

3Department of Mechanics and Aerospace Engineering, Southern University of Science and

Technology, Shenzhen, 518055, China; 4Department of Aerospace Engineering, Iowa State

University, Ames, Iowa 50011, United States; 5Graduate School of Life Science, Hokkaido

University, Sapporo, 001-0021, Japan; 6Ministry of Education Key Laboratory of Macromolecular

Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang

University, Hangzhou 310027, China; 7Institute for Chemical Reaction Design and Discovery

(WPI-ICReDD), Hokkaido University, N21W10, Kita-ku, Sapporo, Hokkaido, 001-0021, Japan;

8South China Advanced Institute for Soft Matter Science and Technology, South China University

of Technology, Guangzhou 510640, China）


The double-network (DN) hydrogels have been drawn much attention in the field

of soft materials for their high mechanical strength and toughness.1 However, the

microstructure and morphology evolution of the internal damage in a DN gel has

hardly been revealed. Recently, we succeeded in applying microelectrode technique

(MET) for detecting electrical potential and its spatial distribution of brittle

polyelectrolyte hydrogels.2 In this study, we study the internal structures of the first

network in partially damaged DN gels by using MET, based on the Donnan effect of

the polyelectrolyte first network. We measure the spatial distribution of the electric

potential of the pre-stretched and then re-swollen DN gels. From the anisotropic depth

profiles of potential and re-swelling ratio, the microstructures of DN gels are revealed

at the pre-yielding, yielding, and strain-hardening regimes.

Keywords: DN hydrogels, internal damage, microelectrode technique, Donnan

potential

Reference:

[1] Gong, J. P.; Katsuyama, Y.; Kurokawa, T.; Osada, Y. Double-Network Hydrogels

with Extremely High Mechanical Strength. Adv. Mater. 2003, 15 (14), 1155–1158

[2] Guo, H.; Kurokawa, T.; Takahata, M.; Hong, W.; Katsuyama, Y.; Luo, F.; Ahmed,

J.; Nakajima, T.; Nonoyama, T.; Gong, J. P. Quantitative Observation of Electric

Potential Distribution of Brittle Polyelectrolyte Hydrogels Using Microelectrode

Technique. Macromolecules 2016, 49 (8), 3100–3108



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P 1-37

Programmed deformations of 3D printed tough physical hydrogels

with metal-coordination complexes

Si Yu Zheng1, Yangyang Shen2, Jin Qian3, Jun Yin2, Zi Liang Wu1*, Qiang Zheng1

（1 Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027,

China; 2 School of Mechanical Engineering, Zhejiang University, Hangzhou 310027, China; 3

Department of Engineering Mechanics Zhejiang University, Hangzhou 310027, China.)


Shape morphing hydrogels have emerging applications in biomedical devices,

soft robotics and so on. However, successful applications require a combination of

excellent mechanical properties and fast responding speed, which are usually a

trade-off in hydrogel-based devices. Here we describe a facile approach to fabricate

three-dimensional (3D) gel constructs by 3D printing of tough physical hydrogels,

which showed programmable deformations with high response speed and large output

force. Highly viscoelastic poly(acrylic acid-co-acrylamide) (P(AAc-co-AAm)) and

poly(acrylic acid-co-N-isopropyl acrylamide) (P(AAc-co-NIPAm)) solutions or their

mixtures were printed into 3D constructs by using multiple nozzles, which were

transferred into FeCl3 solution for forming robust carboxyl-Fe3+ coordination

complexes. The printed gels containing PNIPAm segment or not exhibited different

responsiveness in concentrated saline solution. The mismatch in response afforded the

combined 3D gel constructs the ability of shape morphing, which can be deformed

into rolls, tubes, and cylinder helices. Because of the small diameter of gel fibers, the

deformation and recovery were completed within 1 min. A four-armed gripper was

designed with holding force as high as 115 times the weight of the gripper. This

strategy should broaden the applications of tough hydrogels toward a diversity of

self-shaping materials with outstanding mechanical properties and fast response.

Keywords: Toughness, 3D printing, Controllable deformation, Fast response

References:

[1]. Zheng SY; Shen Y; Zhu F; Yin J; Qian J; Fu J.; Wu ZL; Zheng Q, Adv. Funct.

Mater. 2018, 28, 1803366.



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P 1-38

Programmed multi-stable configurations of composite hydrogels with

in-plane and through-thickness gradients

Chen Yu Li1, Wei Hong2, Zi Liang Wu1*, Qiang Zheng1

（1Department of Polymer Science and Engineering, Zhejiang University Hangzhou 310027,

China; 2Department of Mechanics and Aerospace Engineering, Southern University of Science

and Technology, Shenzhen 518055, China)


Morphing materials have promising applications in various fields, and program

of complex configurations has been realized by incorporating different structures with

through-thickness gradient or different responsive materials. However, how to obtain

multiple configurations at the same condition, i.e. multi-stable configurations, still

remains a challenge. In-plane gradient-induced out-of-plane buckling has been studies

theoretically and experimentally. Owing to the absence of through-thickness gradient,

buckling unit has two possible configurations with equal probability, which can be

controlled by a pre-swelling process. In-plane gradient is integrated with

through-thickness one to obtain programmable and controllable complex 3D

configurations by photo-patterning high-swelling

poly(acrylamide-co-2-acrylamido-2-methylpropanesulfonic acid) (P(AAm-co-AMPS))

in non-swelling polyacrylamide (PAAm) gel. Therefore, integrating multiple (n)

buckling units will afford the composite hydrogel multiple (2n) configurations. This

work provides a concept to program complex composite hydrogels with multi-stable

configurations at one condition, which will benefit the development of intelligent

devices and robotics.

Keywords: Hydrogel, Morphing structures, Programmed deformation, In-plane

gradient, Multi-stability




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P 1-39

Mechanical Property of Polyelectrolyte Networks

Ao-kai Zhang

Changzhou Vocational Institute of Light Industry, Changzhou 213164, China


Structure-property relationship of polyelectrolyte networks is a issue long under

debate due to the complex interplay of microscopic short and long range interactions.

Here we perform molecular dynamics simulations to obtain the equilibrium and

mechanical properties of polyelectrolyte networks as a function of chain length and

electrostatic strength(including bjerrum length and ion valency). We find that

maximum strain of polyelectrolyte network is controlled by electrostatic strength,

which determines chain extension. Maximum stress scales with chain length, and is

also affected by electrostatic force. Our results provide a versatile tool for predicting

mechanical property of polyelectrolyte networks.

Keywords: Gel, Molecular dynamics, Toughness, Polyelectrolyte

References:

[1]. Mann BA.; Holm C.; Kremer K., The Journal of Chemical Physics. 2005, 122,

154903




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P 2-1

Adhesive, self-healable, and transparent micro-crosslinked

organogels as flexible sensor

Zhi Xing Zhang, Fei Zhang, Lin Tang, Wei Feng

（School of Materials Science and Engineering, Tianjin University, Tianjin Key Laboratory of

Composite and Functional Materials, Tianjin 300072, P.R China.）


Gel materials with liquid as dispersing medium have great potentials for

applications in electronic skin, biomedical sensors, soft robotics, and so on [1,2].

However, traditional hydrogels are easy to lose water and thus lose elasticity, which

largely limit their applications [3]. Hence, organogels are developed for addressing the

above drawbacks [4]. A series of organogels based lauryl acrylate are designed, which

possess novel comprehensive performances, including mechanical adaptation,

self-healability, self-adhesion and high transparency. We demonstrate this organogel

combined with conductive materials as a pressure sensor to exhibit stable operation

after repeated loadings. Meanwhile, the resulting sensor also can be sensitive toward

temperature and strain. This work provides a new design concept to fabricate flexible

sensors, which might not only show great potential in applications such as artificial

intelligence, human/machine interactions, personal healthcare, and wearable devices,

but also promote the development of next-generation mechanically adaptable

intelligent skin-like devices.

Keywords: Organogels, Self-healability, Self-adhesion, Flexible sensor

References:

[1]. Rong QF.; Lei W.; Liu MJ*, Chem-Eur. J. 2018, 24, 16930-16943.

[2] Yuk H.; Lu B.; Zhao X*, Chem. Soc. Rev. 2019, 48, 1642-1667.

[3] Zhao T.; Wang G.; Hao D.; Chen L.; Liu K.; Liu M*, Adv. Funct. Mater. 2018,

28, 1800793.

[4] Xie W.; Duan J.; Wang H.; Li J.; Liu R.; Yu B.; Zhou J*, J. Mater. Chem. A

2018, 6, 24114-24119.


51803149).




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P 2-2

Highly Stretchable, Electrically Conductive and Temperature

Tolerant Ionogels for Flexible Sensors

Jialiang Lai, Hongwei Zhou†††††††††††††

（School of Materials and Chemical Engineering, Xi'an Technological University, Xi'an, 710021,

P. R. China）


Highly stretchable, electrically conductive and temperature tolerant ionogels

have been constructed by crosslinking polymeric matrixes with macromolecular

cross-linkers. Poly(acrylic acid) (PAA) network cross-linked by double-bond

end-capped Pluronic F127 (F127DA) is selected as the flexible matrix, and

1-ethyl-3-methylimidazolium dicyanamide ([EMIm][DCA]) is physically locked in

the PAA network as the conductive and temperature tolerant component. The

resulting ionogels are highly stretchable (>850%), tough and fatigue resistant, and

they are also conductive (1.9 S m−1), transparent (>85%) and temperature tolerant. On

the basis of the PAA ionogels, resistive-type sensors and capacitive-type sensors are

assembled and further applied in monitoring large human motions and subtle

physiological activities, including moving of two hands, bending of joints, moving of

the bicipital muscle, breathing, swallowing and touching. It is believed that such

ionogels may find potential applications not only in sensors, but also in other devices

such as flexible supercapacitors, transistors, batteries and actuators.

Keywords: Ionogel, flexible sensor, high stretchability, ionic liquid, Pluronic F127

References:

[1] Z. W. Wang, H. W. Zhou,* J. L. Lai, B. Yan, H. B. Liu, X. L. Jin, A. J. Ma, G.

Zhang, W. F. Zhao and W. X. Chen, Extremely stretchable and electrically conductive

hydrogels with dually synergistic networks for wearable strain sensors, Journal of

Materials Chemistry C, 2018, 6, 9200-9207.

[2] Z. W. Wang, H. W. Zhou,* W. X. Chen, Q. Z. Li, B. Yan, X. L. Jin, A. J. Ma, H.

This work was supported by the National Natural Science Foundation of China (No. 51603164),

Natural Science Basic Research Plan in Shaanxi Province of China (Nos. 2016JQ5036,

2019JM-124)



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136

B. Liu and W. F. Zhao, Dually Synergetic Network Hydrogels with Integrated

Mechanical Stretchability, Thermal Responsiveness, and Electrical Conductivity for

Strain Sensors and Temperature Alertors, ACS Applied Materials & Interfaces,

2018, 10, 14045-14054.

[3] J, L, Lai; H. W. Zhou,* M.C. Wang, Y. K. Chen, Z.Y. Jin, S. L. Li, J. J. Yang, X.

L. Jin, H. B. Liu, W.F. Zhao, Recyclable, stretchable and conductive double network

hydrogels towards flexible strain sensors, Journal of Materials Chemistry C, 2018,

6, 13316-13324.

[4] H. W. Zhou,∗ X. L. Jin, B. Yan, X. J. Li, W. Yang, A. J. Ma, X. H. Zhang, P. Li,

X. B. Ding, W. X. Chen,* Mechanically Robust, Tough, and Self-Recoverable

Hydrogels with Molecularly Engineered Fully Flexible Crosslinking Structure,

Macromolecular Materials & Engineering, 2017, 302, 1700085.

[5] H. W. Zhou,∗ M. Zhang, J. C. Cao, B. Yan, W. Yang, X. L. Jin, A. J. Ma, W. X.

Chen, X. B. Ding, G. Zhang, Highly Flexible, Tough, and Self-Healable Hydrogels

Enabled by Dual Cross-Linking of Triblock Copolymer Micelles and Ionic

Interactions, Macromolecular Materials & Engineering, 2017, 302, 1600352.



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P 2-3

A Shorter Alkyl Chain Dominated Self-Assembly of Homochiral

Nanotubes in Heterochiral Lipid Organogels

‡‡‡‡‡‡‡‡‡‡‡‡‡Xuefeng Zhu‡1, Yuqian Jiang‡2, Dong Yang1, Li Zhang1, Yuangang Li1,

Minghua Liu1*

（1Beijing National Laboratory for Molecular Science (BNLMS), CAS Key Laboratory of Colloid

Interface, and Chemical Thermodynamics, Institute of Chemistry, Chinese Academy of Sciences,

Beijing 100190, P. R. China; 2National Center for Nanoscience and Technology, Beijing 100190, P.

R. China）


It is important to achieve homochiral materials from a molecular, supramolecular

level to nanoscale and mesoscopic dimension. While it has been regarded that the

“majority rule” guides the homochiral self-assembly of enantiomer mixtures, it still

remains a big challenge to manipulate homochirality in a complex system. In this

report, a new case deviated from the “majority rule” was demonstrated, wherein

homochiral nanotubes self-assembled from a mixture of heterochiral lipids through an

alcoholic gelation process. When two heterochiral lipids with mirror head but a

2-methylene discrepancy in alkyl tail are mixed, homochiral nanotubes are always

formed regardless of their mixing ratio. The tubular helicity is exclusively controlled

by the molecular chirality of the shorter lipids. MD simulation further reveals that the

match of both the alkyl chain length and hydrogen-bonding between two heterochiral

lipids plays an important role in the cooperative self-assembly. This work offers a

new insight into supramolecular chirality and guidance in exploring homochiral

materials in complex self-assembly systems including supramolecular gels.

Keywords: Chirality, Self-Assembly, Lipid Nanotube, Gel, Complex System

References:

[1]. Palmans A.; Meijer E., Angew. Chem., Int. Ed., 2007, 46, 8948.

[2]. Perez-Garcia L.; Amabilino D., Chem. Soc. Rev., 2007, 36, 941.

[3]. Liu M.*; Zhang L.; Wang T., Chem. Rev., 2015, 115, 7304.

[4]. Zhu X.; Jiang Y.; Yang D.; Zhang L.; Li Y.; Liu M., Chem. Sci., 2019, 10, 3873.

This research was supported by the National Natural Science Foundation of China (21890734),

Strategic Priority Research Program of the Chinese Academy of Sciences (XDB12020200), and

Key Research Program of Frontier Sciences, CAS, (QYZDJSSW-SLH044).



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138

P 2-4

Anti-freezing, non-drying tough organohydrogel with good flexibility

and conductivity

Juan Li§§§§§§§§§§§§§

, Dongyang Lou, Xiaoyi Sun*

（College of Chemistry and Chemical Engineering, Central South University, 932 Lushan Road,

Changsha, Hunan 410083, China）

*E-mail: [email protected]; [email protected]

Recent progress of tough hydrogel has attracted a lot attention not only in

biomedicine, but also as soft electronic devices, sensors, and robotic actuators.

However, most of hydrogels lose their flexibility below the freezing point of water

and are easy to dehydrate in hot environment.

A novel double-network (DN) organohydrogel of PAMPS/PAAm, obtained by

solvent displacement from ethylene glycol solution of lithium salt, retains high

mechanical performance, flexibility and conductivity in the temperature range of

−80～120 oC. This work provides a new strategy to prepare flexible organohydrogels,

towards the fields of flexible electronic sensors.

Keywords: Gel, Flexibility, Conductivity, Toughness

References:

[1] Gong, J. P.; Katsuyama, Y.; Kurokawa, T.; Osada, Y., Adv. Mater. 2003, 15 (14),

1155-1158.

[2] Rong, Q.; Lei, W.; Chen, L.; Yin, Y.; Zhou, J.; Liu, M., Angew. Chem. Int. Ed.

2017, 56 (45), 14159-14163.

This research was supported by the National Natural Science Foundation of China (No. 21574147),

the Hunan Provincial Natural Science Foundation of China (No. 2018JJ2483) and the

Innovation-Driven Project of Central South University (No. 2017CX020).



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139

P 2-5

Organic or inorganic crystallization in functional molecular gels

Pan Han1, Kai Qiang Liu**************1, Yu Fang1

（1Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, School of

Chemistry and Chemical Engineering, Shaanxi Normal University, Xi’an 710119, P. R. China）


As a recently developed medium for crystal growth, molecular gels derived from

low-molecular-mass gelators (LMMGs), are a typical class of soft materials in which

gelator molecules can be assembled into dynamic three-dimensional networks via

cooperative supramolecular interactions. The gel matrix commonly entraps solvent

molecules and prevents the macroscopic flow of the solvent within its networks.

Therefore, the gel media suppress sedimentation or aggregation of the crystals and

prevent the arbitrary growths along faces in contact with the vessel walls. As proved,

the molecular gel acts as an inert matrix repressing heterogeneous nucleation and

making homogenous nucleation dominant or affords an activated gel structure

enhancing heterogeneous nucleation. The gel 3D network could provide spatial

confinements for the growth of 1D organic semiconductor crystals (e.g. fullerene, etc.)

along the directional dispersion of anti-solvent, or strong or weak couplings for

spatially confined growth of organic or inorganic crystals (organic semiconductor,

pharmaceuticals, and metal nanocrystals, etc.).

Keywords: Molecular gel, Crystal, Spatial confinement, Coupling effect

References:

[1]. Liu KQ.*; Gao S.; Zheng Z.; Deng XL.; Mukherjee S.; Wang SS.; Xu H.; Wang

JQ.; Liu JF.; Zhai TY.*; Fang Y*, Adv. Mater. 2019, 31, 1808254.

[2] Wang SS.; Liu KQ.*; Gao S.; Wang JQ.; Marella RK.; Fang Y*, Soft Matter 2017,

13, 8609.

[3] Gao S.; Wang SS.; Ma J.; Wu Y.; Fu XW.; Marella RK.; Liu KQ.*; Fang Y,

Langmuir 2016, 32, 12805.

[4] Kumar DK.; Steed JW*, Chem. Soc. Rev. 2014, 43, 2080.


21872091, 21473110).



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P 3-1

Oil-water separation, Lightweight, Flexible and Thermally-Insulating

Aerogels Derived from wood Nanofibrillated Cellulose

Yu Meng, Jianye Huang,Yanxiao Yang, Xuning Tan, Chenchen Dai, Qing Li*

（College of Materials Science and Engineering, Northeast Forestry University, Harbin150040,

China.）

*E-mail: liqing2016@ nefu.edu.cn

Nowadays, environmental pollution is becoming more and more serious. Organic

substances, oils and fats and various mixed pollutants have seriously affected people's

production and life. Therefore, it is extremely urgent to find a simple and effective

method to degrade pollutants. In the context of global consensus on renewable

resources, the rational development of wood resources has attracted the attention of

many researchers. The high-aspect-ratio wood-derived nanofibrillated cellulose (NFC)

was utilized as building blocks to construct aerogels. The wood NFC formed strong

web-like entangled structures that acted as the skeletal support of aerogels, exhibiting

a low density. The wood NFC aerogels (WoNAs) were soft, flexible, and illustrated

good resilience performance after compression release. The WoNAs had a high

oil-water separation capacity arising from the small aperture (diameter is 1∼10 nm)

and high aspect ratio of wood NFC, demonstrating their application suitability in

oil-water separation. In this paper, the mixture of soybean oil and distilled water is the

main oil-water separation object. Several NFC solutions with different concentration

gradients are prepared, and then sixteen different nanometer specifications are

prepared by freeze-drying method. Among them, the separation efficiency of aerogels

with the concentration of 0.5%-20ml is the best, which can achieve quickly oil-water

separation. The continuous oil-water separation performance of nanocellulose aerogel

shows that the 1975 ml oil-water mixture can be separated at one time with a

separation effect of 19515 g/g, which can be used for continuous separation of oils

and micro-nanoparticles. Further, the WoNAs exhibited an excellent thermal

insulating performance and insulation stability at various temperatures owing to their

porous structures and high thermal stability. The WoNAs fabricated herein are thus

expected to be a novel member of the filtration Separation Material owing to their

intrinsic characteristics attained by integrating multiple structural and performance

advantages into the one.

Keywords: Nanofibrillated cellulose, Aerogels, Flexibility, Oil-Water separation,

Thermal insulation



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Fig.1 Comparisons of Experimental Devices and Digital Photos before and after

Oil-Water Separation: (a, b) Pictures before and after the separation of soybean

oil-water; (c, d) Pictures before and after the separation of petroleum-water;(e)

Oil-water separation rate curve;(f) Separation rate curve of aerogels under harsh

environment

Fig.2 Contact angle test results of WoNAs under HCl, NaOH, NaCl, hot water and ice

water conditions: (a) contact angles of aerogels and Dichloromethane under various

conditions; (b) contact angles of aerogels and Dichloroethane under various conditions;

(c) contact angles between aerogels and Carbon tetrachloride under various conditions

References:

[1]. Wang Y.; Uetani K.; Liu S.; et al. ChemNanoMat, 2016.

[2]. Gustafsson S J.; Mihranyan A.; ACS Applied Materials & Interfaces, 2016,

8(22):13759.

[3]. Gustafsson S.; Lordat P.; Hanrieder T.; et al. Mater. Horiz. 2016:10.1039.

[4]. Chen W.; Li Q.; Wang Y.; et al. ChemSusChem, 2014, 7(1): 154-161.

[5]. Wang Y.; Uetani K.; Liu S.; et al. ChemNanoMat, 2017, 3(2): 98-108.

[6]. Venkataraman M.; Mishra R.; Kotresh T M.; et al. Textile Progress, 2016, 48(2):

55-118.



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P 3-2

Preparation and characterization of ultra-fast

Temperature-responsive nanofibrous hydrogel

Xie Zheng, Liusheng Zha††††††††††††††

（State Key Laboratory for Modification of Chemical Fibers and Polymer Materials & College of

Materials Science and Engineering, Donghua University, Shanghai, 201620, China.）


As we know, one of the shortages of traditional temperature-responsive

hydrogels is their low response rate due to the dense skin layer formed on their

surfaces during their contraction process, which severely limits their applications in

the fields such as controlled drug release, sensor and actuator. Improvement of their

response rate has been attracting the attention of many researchers. In this work, a

ultra-fast temperature-responsive nanofibrous hydrogel was prepared by freeze drying

the dispersion of shortened electrospun poly(N-isopropylacrylamide-co-

N-hydromethylacrylamide) nanofibers in t-butanol, followed by heat treatment to

produce chemical linkages inside the nanofibers or between them. Its hierarchical

porous structure, observed by scanning electron microscope, consists of the major

pores with an average diameter of 43.8 μm and the minor pores with the one of 4.2

μm. When the environmental temperature is changed between 26 ℃ and 55 ℃, the

swelling equilibrium of the nanofibrous hydrogel can be achieved within 34 s.

Comparatively, the bulky poly(N-isopropylacrylamide) hydrogel of the same size

needs 1.1 h to achieve the equilibrium.

Keywords: Rapid response, Nanofibrous hydrogel, Temperature responsiveness

References:

[1]. Maeda S*; Kato T.; Kogure H.; Hosoya N, Appl. Phys. Lett. 2015, 106, 171909

[2]. Liu Z.; Wei J.; Faraj Y.; Ju XJ.; Xie R.; Wang W.; Chu LY*, Can. J. Chem. Eng.

2018, 96, 2100

[3]. Zheng X.; Liu XY.; Zha LS*, Macromol. Mater. Eng. 2019, 1900125


51373030).



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P 3-3

Cu/Cu2O/CuO Nanoparticles Loaded on Porous Carbon from a

Novel Hypercrosslinked Porous Polymer for Catalytic Reduction of

4-Nitrophenol

Xue sun, Xiao Li, Jiaojiao Mao, Caihong Li, Yuelin Yang, Weiying Zhang,

Xiaoguang Ying, Jianying Huang

（Fujian Key Laboratory of Advanced Manufacturing Technology of Special Chemicals, College of

Chemical Engineering, Fuzhou University, Quanzhou 362100, China.）


In the past several decades, the catalysts have been extensively investigated for

scientific and industrial applications. It is well known that agglomeration of catalysts

leads to the decrease of catalytic activity. Herein, a novel hypercrosslinked porous

polymer containing copper ions are first prepared by an external cross-linker using

β-cyclodextrin and tannic acid complexes as monomers. Then the Cu/Cu2O/CuO

heterostructural nanoparticles loaded on porous carbon framework for the catalytic

reduction of 4-nitrophenol are produced by pyrolysis of the hypercrosslinked porous

polymer. The copper-based catalyst nanoparticles are uniformly dispersed on the

porous carbon. With the loading of catalyst about 0.03 wt%, the turnover frequency

(TOF) for the conversion of 4-nitrophenol to 4-aminophenol can reach 0.758 mg/mg·s.

Therefore, the Cu/Cu2O/CuO@Carbon has high catalytic activity, and its preparation is

simple, which provides a new idea for the fabrication of supported catalysts.

Keywords: Hypercrosslinked porous polymers, Porous carbon, Copper catalyst,

4-nitrophenol

References:

[1] Davankov V A, Tsyurupa M P. Hypercrosslinked polymeric networks and

adsorbing materials: Synthesis, properties, structure, and applications[M]. Elsevier,

2011.

[2] Li B, Gong R, Wang W, et al. A New strategy to microporous polymers: Knitting

rigid aromatic building blocks by external cross-linker[J]. Macromolecules, 2011,

44(8): 2410-2414.

*This research was supported by the Natural Science Foundation of Fujian Province, China (Grant

No. 2019J01652) and the Science and Technology Project of Fuzhou, China (No.2018-G-67).



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P 3-4

Synthesis of leafy-shape TiO2-C nanosheets by alkaline treatment of

Ti3C2Tx MXene

Na Zhao1, Yang Hu1, Jinlong Du2, Jing Peng1, Maolin Zhai1‡‡‡‡‡‡‡‡‡‡‡‡‡‡.

（ 1. Beijing National Laboratory for Molecular Sciences, Radiochemistry and Radiation

Chemistry Key Laboratory of Fundamental Science, the Key Laboratory of Polymer Chemistry

and Physics of the Ministry of Education, College of Chemistry and Molecular Engineering,

Peking University, Beijing 100871, China.

2. State Key Laboratory of Nuclear Physics and Technology, School of Physics, Peking University,

Beijing 100871, P. R. China.）


MXenes is an emerging family of two-dimensional (2D) metal carbides,

carbonitrides and nitrides. Its general formula is Mn+1XnTx (M, X, and T stand for

transition metal, carbon/nitrogen, and surface terminations such as OH, O, and F,

respectively). Because of their high metallic conductivity and rich surface properties,

the Ti3C2Tx MXene are regarded as “hydrophilic graphene” or “conductive clay” [1],

which are potential materials to fabricate the 3D porous aerogels. MXene-sponge[2]

and MXene/graphene composite aerogels[3, 4] have been prepared for the applications

of supercapacitoers, piezoresistive sensor and so on.

Herein we prepared the amorphous TiO2-C nanosheets derived from Ti3C2Tx

MXene by a simple alkaline treatment at room temperature, which was confirmed by

the XPS and XRD. What’s more, the existence of oxygen vacancies of the amorphous

TiO2-C was confirmed by EPR spectroscopy with the g-value of 2.004[5, 6]. While in

the TEM images, we found that the alkaline treatment did not change the morphology

of Ti3C2Tx obviously. As shown in Fig.1a-c, the Ti3C2Tx nanosheets shows a uniform

2D leafy shape with a single layer and multilayers. After the alkaline treatment (Fig.

1d-f), the leafy shape was preserved in the alkalized Ti3C2Tx nanosheets, which are

mainly composed of multilayers. Base on the above analysis, we conceive that in this

structure, amorphous TiO2 with a large number of O vacancy is supported by 2D

planar carbon nanosheet. And due to the leafy shapes, abundant Oxygen vacancies

and high metallic conductivity, amorphous TiO2-C could be used for fabricating 3D

This research was supported by the Science Challenge Project (No. TZ2018004) and National

Natural Science Foundation of China (11575009, 11405168).




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145

aerogel, which were further applied for photocatalysis material, electrode materials of

supercapacitor and lithium-ion batteries.

Keywords: Ti3C2Tx MXene, Alkaline treatment, Amorphous TiO2-C, Oxygen

vacancies.

Fig. 1. TEM images in different magnifications of: (a-c) pristine Ti3C2Tx nanosheets

before alkaline treatment, (d-f) corresponding as-treated Ti3C2Tx nanosheets.

References:

[1] Naguib, M.; Kurtoglu, M.; Presser, V.; Lu, J.; Niu, J.; Heon, M.; Hultman, L.;

Gogotsi, Y.; Barsoum, M. W., Two-dimensional nanocrystals produced by exfoliation

of Ti3AlC2. Adv. Mater. 2011, 23 (37), 4248-4253.

[2] Yue, Y.; Liu, N.; Liu, W.; Li, M.; Ma, Y.; Luo, C.; Wang, S.; Rao, J.; Hu, X.; Su,

J.; Zhang, Z.; Huang, Q.; Gao, Y., 3D hybrid porous Mxene-sponge network and its

application in piezoresistive sensor. Nano Energy 2018, 50, 79-87.

[3] Li, L.; Zhang, M.; Zhang, X.; Zhang, Z., New Ti3C2 aerogel as promising

negative electrode materials for asymmetric supercapacitors. J. Power Sources 2017,

364, 234-241.

[4] Ma, Y.; Yue, Y.; Zhang, H.; Cheng, F.; Zhao, W.; Rao, J.; Luo, S.; Wang, J.;

Jiang, X.; Liu, Z.; Liu, N.; Gao, Y., 3D synergistical MXene/reduced graphene oxide

aerogel for a piezoresistive sensor. ACS Nano 2018, 12 (4), 3209-3216.

[5] Fu, F.; Shen, H. D.; Sun, X.; Xue, W. W.; Shoneye, A.; Ma, J. N.; Luo, L.; Wang,

D. J.; Wang, J. G.; Tang, J. W., Synergistic effect of surface oxygen vacancies and

interfacial charge transfer on Fe(III)/Bi2MoO6 for efficient photocatalysis. Appl. Catal.

B-Environ. 2019, 247, 150-162.

[6] Liu, N.; Xu, M.; Yang, Y.; Zhang, S.; Zhang, J.; Wang, W.; Zheng, L.; Hong, S.;

Wei, M., Auδ−–Ov–Ti3 interfacial site: catalytic active center toward low-temperature

water gas shift reaction. ACS Catal. 2019, 9 (4), 2707-2717.



June 14-17, 2019

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P 3-5

Removal of Perrhenate using Radiation Synthesized Hierarchically

Macro/Mesoporous Silica-gratft-Quaternary Phosphonium

Xingxiao Li, Dong Han, Jing Peng, Jiuqiang Li and Maolin Zhai*

Beijing National Laboratory for Molecular Sciences, Radiochemistry and Radiation Chemistry

Key Laboratory of Fundamental Science, the Key Laboratory of Polymer Chemistry and Physics

of the Ministry of Education, College of Chemistry and Molecular Engineering, Peking University,

Beijing 100871, China.

**E-mail:[email protected]

Keywords: Perrhenate, Radiation grafting, Hierarchically silica, Quaternary

phosphonium

Rhenium (Re) is one of the rare dispersed elements with the content of only 1

ppb in the earth crust. Due to the excellent properties of Re and Re alloys, they have

become one of the irreplaceable materials in modern high-tech fields, such as the

national defense, aerospace, petrochemical industry and so on. The demand for Re has

been rising recently, and the recycling of Re resources has become more urgent.[1] In

addition, Re has been widely used as the analogue of radioactive Tc to facilitate the

operation in ordinary laboratories[2, 3]. Thus, it is important to develop adsorbents of

Tc/Re considering environmentally and economically importance. Hierarchically

silica can avoid the disadvantages of macro pores and mesopores by virtue of the

special pore structures. And it has excellent chemical stability, thermal stability and

mechanical properties to withstand high acidity, high temperature, radioactivity and

other special environments. Therefore, hierarchically silica is a very good adsorption

substrate[4].

Herein, a novel adsorbent named as HPS-C-P was synthesized for removal of

ReO4- by two-step γ-ray radiation grafting 4-vinylbenzyl phosphonium chlorid onto

silanized hierarchilly silica, the synthesis route of HPS-C-P was shown in Figure 1. It

was found that the grafting yield positively correlated with monomer concentration

and absorbed dose. By controlling the reaction conditions two kinds of adsorbents

with the grafting yield of 0.251 and 0.782 mmolg-1 were synthesized, which was

named as HSP-C-P1 and HPS-C-P2, respectively. Both HPS-C-P1 and HPS-C-P2 had

fast adsorption kinetics for ReO4- (Figure 2). And their maximum adsorption

capacities were 46.9 and 140.5 mgg-1 calculated by modified Langmuir model,

respectively. The selectivity factor of HSP-C-P2 and HPS-C-P1 toward ReO4- relative

to NO3- were 159 and 64, respectively, which indicated good adsorption selectivity.

They also had good cycle performance, and can be desorbed by 1.9 M HNO3. XPS

and FTIR indicated the adsorption mechanism of HPS-C-P for ReO4- was ion

exchange.



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147

Figure 1 the synthetic route of HPS-C-P

Figure 2 Adsorption kinetics of ReO4- onto HPS-C-P

References

[1] Wang, Y.; Wang, C. Y., Recent advances of rhenium separation and enrichment in China:

Industrial processes and laboratory trials. Chinese Chemical Letters, 2018, 29(3), 345-352.

[2] Mei, L.; Li, F. Z.; Lan, J. H.; Wang, C. Z.; Xu, C.; Deng, H.; Wu, Q. Y.; Hu, K. Q.; Wang, L.; Chai,

Z. F.; Chen, J.; Gibson, J. K.; Shi, W. Q., Anion-adaptive crystalline cationic material for 99TcO4-

trapping. Nature Communications, 2019, 10.

[3] Han, D.; Li, X. X.; Cui, Y.; Yang, X.; Chen, X. B.; Xu, L.; Peng, J.; Li, J. Q.; Zhai, M. L.,

Polymeric ionic liquid gels composed of hydrophilic and hydrophobic units for high adsorption

selectivity of perrhenate. Rsc Advances, 2018, 8(17), 9311-9319.

[4] Li, X. X.; Hang, D.; Guo, T. T.; Peng, J.; Xu, L.; Zhai, M. L., Quaternary Phosphonium Modified Hierarchically Macro/Mesoporous Silica for Fast Removal of Perrhenate. Industrial &

Engineering Chemistry Research, 2018, 57(40), 13511-13518.



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148

P 3-6

Zein-based composite film with pH-sensitivity for drug controlling

release

Junhui Guo, Yufeng He*, Jianfeng Wang, Rongmin Wang§§§§§§§§§§§§§§

（Key Laboratory of Eco-Environment-Related Polymer Materials of Ministry of Education,

Institute of Polymer, College of Chemistry and Chemical Engineering, Northwest Normal

University, Lanzhou 730070, China.）


Films can be directly applied to the surface of the skin wound or mouth ulcer that

make drug and lesion can directly contact and improve the utilization rate of drug[1].

Commonly, synthetic polymers and natural polymers are used to prepare film-forming

materials. Furthermore, natural polymers have some advantages of biodegradability,

biocompatibility, renewability, safety and reliability. Zein, as a typical natural

polymers, has been paid to attention[2].

Here, using zein and nano-SiO2 as raw materials, the zein-based composite film

was prepared. Its morphology and structure were characterized by FT-IR, SEM and

TG. It was found that the obtained organic-inorganic hybrid polymer membrane was

uniform and transparent, and SiO2 was uniformly dispersed in the membrane which

improved its mechanical properties. By loading the vitamin B2 into the zein-based

composite film, its release behaviors were investigated. It was found that the release

rate got to 95% at neutral medium (pH: 7.4), which is much higher than that of in

weak acidic environments (pH: 5.8). The drug-loaded film was pH sensitive because

of addition of SiO2. That means the obtained zein-based composite film can be used

as a carrier for treating skin wounds or mouth ulcers.

Keywords: Natural polymers, Zein, pH-sensitive, Drug release

References:

[1] Li FY.; Wang RM.; He YF.; Li XX.; Song PF.; Yin XC.; Mao CW, Journal of

Controlled Release, 2011, 152,e92.

[2] Lv SY.; Liu J.; Pei F.; He YF.; Wang RM, Letters in Drug Design & Discovery,

2016, 13, 1099.


21364012, 21865030).



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P 3-7

Zein-based magnetic polymer aerogel as oil absorbing agent

Fawei Wang, Jianfeng Wang, Yufeng He, Rongmin Wang***************





Oil pollution is an important category of environmental pollution. Therefore, the

disposal of oily wastewater has become a worldwide challenge, and several

approaches have been proposed and employed to extract oil from water or realize

oil/water separation [1]. At present, oil-absorbing materials are mainly composed of

synthetic polymers, which is difficult to degrade to cause secondary pollution. As an

inexpensive natural polymer, zein is an amino acid-based vegetable protein with

biocompatibility and biodegradability. We found that zein can be used to prepare

edible composites and controlled release materials [2]. Herein, using sol-gel method

and freeze-drying technique, the zein-based polymer aerogel was prepared by zein

and poly (vinyl alcohol) (PVA). With further surface modification by silane coupling

agent and in-situ precipitation for introducing Fe3O4, the zein-based magnetic

polymer aerogel was successively prepared. Its morphology and structure were

characterized by FT-IR, SEM and TG. It indicated that the polymer aerogel had a

multi-layered network structure and the contact angle was 132.8o. The modified

aerogel have significant capabilities of oil-water separation, which will provide

efficient and sustainable options for water treatment and environmental protection.

Keywords: Natural polymers, Zein, Aerogel, Oil absorbing materials

References:

[1] Ma Q.; Yu Y.; Sindoro M.; Fane, A. G.; Wang R.; Zhang H, [J]. Adv. Mater. 2017,

29 (13): 1605361.

[2] Lv S.; Liu J.; Pei F.; He Y.; Wang R-M, [J]. Letters in Drug Design & Discovery.

2016, 13(10): 1099.


21364012, 21865030).



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P 3-8

Microstructure and mechanical properties of aerogels prepared by

Freeze casting

Wang Liao

School of Science, Xihua University, Chengdu 610039 China

Abstract Aerogels are known as the lightest solids, and have the applicable

mechanical properties and various functions. In recent years, the family members of

aerogels and their applications expand rapidly. One reason for that is the preparation

process of freeze casting (FC) is simple and green. Inorganic aerogels, metal aerogels,

polymer aerogels and composite aerogels with different properties, such as thermal

insulation materials, sensors, electromagnetic interference shielding, absorbent,

separation, life science, supercapacitors, catalysis, etc. have been produced by this

method. Despite of this, the definition and influence factors of FC have not been

carefully analyzed in the literature, which becomes a bottleneck for novel aerogels

through this way. In this work, three different types of FC are distinguished and the

factors that affect the microstructure and physical properties are discussed.

Key words: aerogel; freeze casting; microstructure; mechanical properties



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P 3-9

Controlled preparation of Nitrogen-doped carbon cryogels with

excellent carbon dioxide adsorption performance

Ze Liang Li1, Wei Gang Zhao1*

(College of Material Engineering, Fujian Agriculture and Forestry University, Fuzhou 350002,

PR China)


A series of cost effective nitrogen-doped carbon cryogels with excellent carbon

dioxide (CO2) adsorption performance were prepared from phenol, melamine and

formaldehyde (PMF) by sol-gel method, freeze-drying and carbonization. The

morphology, pore structure and chemical characteristics were investigated by

scanning electron microscopy (SEM), N2 adsorption-desorption at 77 K, X-ray

diffraction (XRD), X-ray photoelectron spectrometry (XPS) and Fourier transform

infrared spectroscopy (FTIR). The results show that the carbon cryogel is a kind of

porous material composed of nanoparticles stacked together, which has high specific

surface area (1406m2/g), high porosity and micropore capacity. Moreover, nitrogen

elements are firmly bound in the framework of carbon cryogel, and its nitrogen

content ranges 1.0%~2.1%. CO2 adsorption performance of carbon cryogel was tested,

and the results showed that the CO2 adsorption capacity was as high as 5.75mmol/g

(0℃, 1bar) and 4.78mmol/g (25℃, 1bar), which was higher than that of similar

materials, and the carbon cryogel had good CO2/N2 adsorption selectivity. And its

CO2 adsorption capacity and selectivity were correlated with the pore structure and

nitrogen doping of the carbon cryogels.

Keywords: Phenol melamine formaldehyde, Pore structure, Freeze-drying, CO2

capture



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P 4-1

Ionically Cross-Linked Silk Microfibers/Alginate Tough Composite

Hydrogels with Hierarchical Structures

Lei Meng, Changyou Shao, Jun Yang

（Beijing Key Laboratory of Lignocellulosic Chemistry, Beijing Forestry University, Beijing

100083, China.）


Developing hydrogels with enhanced mechanical properties have attracted broad

attention in recent years. In this work, we propose a facile procedure to prepare tough

composite hydrogels by incorporating silk microfibers (mSF) into alginate ionically

cross-linked network. The mSF gives rise to ionic bonds with Ca2+ and interfacial

hydrogen bonds because of the carboxyl groups on the surface of mSF, and the

neighboring alginate chains are interlinked by mSF, which synergistically lead to

efficient energy dissipation and prevention of stress concentration. The attained

composite hydrogels show superior elastic modulus (1.58 MPa), tensile strength (1.60

MPa) and unique adaptive interface response. Moreover, the mechanical properties of

the composite hydrogels can be tailored by the concentration of mSF and

post-crosslinking time by immersing the composite hydrogels in CaCl2 solution.

Intriguingly, the mechanical properties can be further improved through prestretching

methodology to align the alginate chains along the stress direction, where the oriented

hierarchical structures are formed and well-retained in the prestretched composite

hydrogels. We envisage that this study provides a general strategy for designing

composite hydrogels with both excellent and tunable mechanical properties, which

enriches the route of alginate hydrogels for promising applications where

high-loading requirement needed.

Keywords: Hydrogels, Alginate, Silk Fibroin, Reinforcement, Hierarchical Structures

References:



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153

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Funct. Mater. 2017, 28, 1705480. DOI: 10.1002/adfm.201705480.

[25] Trovatti, E.; Carvalho, A. J.; Ribeiro, S. J.; Gandini, A. Simple Green Approach

to Reinforce Natural Rubber with Bacterial Cellulose Nanofibers. Biomacromolecules

2013, 14, 2667-2674. DOI: 10.1021/bm400523h.

[26] Lin, N.; Bruzzese, C.; Dufresne, A. TEMPO-Oxidized Nanocellulose

Participating as Crosslinking Aid for Alginate-Based Sponges. ACS Appl. Mater.

Interfaces 2012, 4, 4948-4959. DOI: 10.1021/am301325r.

[27] Guo, C.; Zhang, J.; Jordan, J. S.; Wang, X.; Henning, R. W.; Yarger, J. L.

Structural Comparison of Various Silkworm Silks: An Insight into the



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Structure-Property Relationship. Biomacromolecules 2018, 19, 906-917. DOI:

10.1021/acs.biomac.7b01687.

[28] Balu, R.; Reeder, S.; Knott, R.; Mata, J.; Decampo, L.; Dutta, N. K.; Choudhury,

N. R. Tough Photocrosslinked Silk Fibroin/Graphene Oxide Nanocomposite

Hydrogels. Langmuir 2018, 34, 9238-9251. DOI: 10.1021/acs.langmuir.8b01141.

[29] Mandal, B. B.; Kapoor, S.; Kundu, S. C. Silk Fibroin/Polyacrylamide

Semi-Interpenetrating Network Hydrogels for Controlled Drug Release. Biomaterials

2009, 30, 2826-2836. DOI: 10.1016/j.biomaterials.2009.01.040.

[30] Feng, Y.; Li, X.; Li, M.; Ye, D.; Zhang, Q.; You, R.; Xu, W. Facile Preparation of

Biocompatible Silk Fibroin/Cellulose Nanocomposite Films with High Mechanical

Performance. ACS Sustainable Chem. Eng. 2017, 5, 6227-6236. DOI:

10.1021/acssuschemeng.7b01161.

[31] Zhu, Z.; Ling, S.; Yeo, J.; Zhao, S.; Tozzi, L.; Buehler, M. J.; Omenetto, F.; Li,

C.; Kaplan, D. L. High‐Strength, Durable All‐Silk Fibroin Hydrogels with Versatile

Processability toward Multifunctional Applications. Adv. Funct. Mater. 2018, 28,

1704757. DOI: 10.1002/adfm.201704757.

[32] Luo, K.; Yang, Y.; Shao, Z. Physically Crosslinked Biocompatible

Silk‐Fibroin‐Based Hydrogels with High Mechanical Performance. Adv. Funct. Mater.

2016, 26, 872-880. DOI； 10.1002/adfm.201503450.

[33] Mandal, B. B.; Grinberg, A.; Gil, E. S.; Panilaitis, B.; Kaplan, D. L.

High-Strength Silk Protein Scaffolds for Bone Repair. Proc. Natl. Acad. Sci. U. S. A.

2012, 109, 7699-7704. DOI: 10.1073/pnas.1119474109.

[34] Shi, L.; Wang, F.; Zhu, W.; Xu, Z.; Fuchs, S.; Hilborn, J.; Zhu, L.; Ma, Q.; Wang,

Y.; Weng, X.; Ossipov, D. A. Self‐Healing Silk Fibroin‐Based Hydrogel for Bone

Regeneration: Dynamic Metal‐Ligand Self‐Assembly Approach. Adv. Funct. Mater.

2017, 27, 1700591. DOI: 0.1002/adfm.201700591.

[35] Wu, M.; Shuai, H.; Cheng, Q.; Jiang, L. Bioinspired Green Composite Lotus

Fibers. Angew. Chem. 2014, 53, 3358-3361. DOI: 10.1002/anie.201310656.



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[36] Wegst, U. G.; Bai, H.; Saiz, E.; Tomsia, A. P.; Ritchie, R. O. Bioinspired

Structural Materials. Nat. Mater. 2015, 14, 23-36. DOI: 10.1038/nmat4089.

[37] Osoriomadrazo, A.; Eder, M.; Rueggeberg, M.; Pandey, J. K.; Harrington, M. J.;

Nishiyama, Y.; Putaux, J. L.; Rochas, C.; Burgert, I. Reorientation of Cellulose

Nanowhiskers in Agarose Hydrogels under Tensile Loading. Biomacromolecules 2012,

13, 850-856. DOI: 10.1021/bm201764y.

[38] Sehaqui, H.; Mushi, N. E.; Morimune, S.; Salajkova, M.; Nishino, T.; Berglund,

L. A. Cellulose Nanofiber Orientation in Nanopaper and Nanocomposites by Cold

Drawing. ACS Appl. Mater. Interfaces 2012, 4, 1043-1049. DOI:

10.1021/am2016766.

[39] Mredha, M. T. I.; Guo, Y. Z.; Nonoyama, T.; Nakajima, T.; Kurokawa, T.; Gong,

J. P. A Facile Method to Fabricate Anisotropic Hydrogels with Perfectly Aligned

Hierarchical Fibrous Structures. Adv. Mater. 2018, 30, 1704937. DOI:

10.1002/adma.201704937.

[40] Liu, J.; Tan, C.; Yu, Z.; Li, N.; Abell, C.; Scherman, O. A. Tough Supramolecular

Polymer Networks with Extreme Stretchability and Fast Room-Temperature

Self-Healing. Adv. Mater. 2017, 29, 1605325. DOI: 10.1002/adma.201605325.

[41] Shang, J.; Chen, S. X. Electrical Behavior of a Natural Polyelectrolyte Hydrogel:

Chitosan/Carboxymethylcellulose Hydrogel. Biomacromolecules 2008, 9, 1208-1213.

DOI: 10.1021/bm701204j.

[42] Silva, R.; Singh, R.; Sarker, B.; Papageorgiou, D. G.; Juhasz, J. A.; Roether, J. A.;

Cicha, I.; Kaschta, J.; Schubert, D. W.; Chrissafis, K. Soft-Matrices Based on Silk

Fibroin and Alginate for Tissue Egineering. Int. J. Biol. Macromol. 2016, 93,

1420-1431. DOI: 10.1016/j.ijbiomac.2016.04.045.

[43] Soares, J. P.; Santos, J. E.; Chierice, G. O.; Cavalheiro, E. T. G. Thermal

Behavior of Alginic Acid and Its Sodium Salt. Eclet. Quím. 2004, 29, 57-64. DOI:

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[44] Yan, L. Y.; Chen, H.; Li, P.; Kim, D. H.; Chanpark, M. B. Finely Dispersed



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Single-Walled Carbon Nanotubes for Polysaccharide Hydrogels. ACS Appl. Mater.

Interfaces 2012, 4, 4610-4615. DOI: 10.1021/am300985p.

[45] Barbetta, A.; Barigelli, E.; Dentini, M. Porous Alginate Hydrogels: Synthetic

Methods for Tailoring the Porous Texture. Biomacromolecules 2009, 10, 2328-2337.

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Hybrid Ionic-Covalent Hydrogels with Tunable Structures and Mechanics. Adv. Mater.

2018, 30, 1707071. DOI: 10.1002/adma.201707071.

[47] Senses, E.; Akcora, P. An Interface-Driven Stiffening Mechanism in Polymer

Nanocomposites. Macromolecules 2013, 46, 1868-1874. DOI: 10.1021/ma302275f.

[48] Li, Y.; Zhou, P.; Feng, A.; Liu, Y.; Lu, C. Dynamic Self-Stiffening and Structural

Evolutions of Polyacrylonitrile/Carbon Nanotube Nanocomposites. ACS Appl. Mater.

Interfaces 2017, 9, 5653-5659. DOI: 10.1021/acsami.6b16029.

[49] Kurniawan, N. A.; Wong, L. H.; Rajagopalan, R. Early Stiffening and Softening

of Collagen: Interplay of Deformation Mechanisms in Biopolymer Networks.

Biomacromolecules 2012, 13, 691-698. DOI: 10.1021/bm2015812.

[50] Erk, K. A.; Henderson, K. J.; Shull, K. R. Strain Stiffening in Synthetic and

Biopolymer Networks. Biomacromolecules 2010, 11, 1358-1363. DOI:

10.1021/bm100136y.



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P 4-2

Effects of zein on the formation of konjac glucomannan electrospun

nanofibres for controlled release of curcumin

Lin Wanga, Ruojun Mua, Yu Dua, Yuanzhao Lia, Chunhua Wua*, Jie Panga*

a College of food science, Fujian Agriculture and Forestry University, Fuzhou,

China, 350002

Abstract: The exploration of methods to produce biodegradable and bioactive

nanofibril films is of great scientific and technological interests. We reported a

strategy for constructiing of nanofibril films by using KGM and zein via

electrospinning technology. The characterization of the nanofibrial films was

conducted via Scanning electron microscopy (SEM), Thermogravimetric analysis

(TGA), Fourier transform infrared spectroscopy (FT-IR), X-ray photoelectron

spectroscopy (XPS), X-ray diffraction (XRD) and water contact angle measurements.

The interactions of hydrogen bonds between KGM and zein was confirmed, and the

addition of zein caused an enhancement of thermal properties and hydrophobicity.

The morphology and size of nanofibers significantly depended on zein contents. We

further loaded curcumin (Cur), a natural polyphenolic compound, within the

KGM/zein nanofibril films to investigate the antibacterial and antioxidating properties

for the novel nanofibril films, and the encapsulation efficiency was close to 95±2.2 %.

In comparison with a pure KGM and zein film, KGM/zein nanofibril films indicated

an excellent antibacterial activity against food-borne pathogens. Our work suggested

that the KGM/zein nanofibril films had a potential application in food packaging,

which opens a facile pathway to the modification of KGM-based biopolymer to form

nanofilms.

Keywords: Konjac glucomannan/zein; Curcumin; Nanofibril film;

Antibacterial/antioxidative properties



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P 4-3

Zein-based composite film with pH-sensitivity for drug controlling

release

Junhui Guo, Yufeng He*, Jianfeng Wang, Rongmin Wang†††††††††††††††





Films can be directly applied to the surface of the skin wound or mouth ulcer that

make drug and lesion can directly contact and improve the utilization rate of drug[1].

Commonly, synthetic polymers and natural polymers are used to prepare film-forming

materials. Furthermore, natural polymers have some advantages of biodegradability,

biocompatibility, renewability, safety and reliability. Zein, as a typical natural

polymers, has been paid to attention[2].

Here, using zein and nano-SiO2 as raw materials, the zein-based composite film

was prepared. Its morphology and structure were characterized by FT-IR, SEM and

TG. It was found that the obtained organic-inorganic hybrid polymer membrane was

uniform and transparent, and SiO2 was uniformly dispersed in the membrane which

improved its mechanical properties. By loading the vitamin B2 into the zein-based

composite film, its release behaviors were investigated. It was found that the release

rate got to 95% at neutral medium (pH: 7.4), which is much higher than that of in

weak acidic environments (pH: 5.8). The drug-loaded film was pH sensitive because

of addition of SiO2. That means the obtained zein-based composite film can be used

as a carrier for treating skin wounds or mouth ulcers.

Keywords: Natural polymers, Zein, pH-sensitive, Drug release

References:

[1] Li FY.; Wang RM.; He YF.; Li XX.; Song PF.; Yin XC.; Mao CW, Journal of

Controlled Release, 2011, 152,e92.

[2] Lv SY.; Liu J.; Pei F.; He YF.; Wang RM, Letters in Drug Design & Discovery,

2016, 13, 1099.


21364012, 21865030).



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P 4-4

Synthesis of self-supporting composite nanowires based on

3D-network metallogel template

Botian Li, Da Xiao, Xue Zhou, Wei Shao,

Inorganic-polymer composite nanowires have triggered enormous interest

because of their unique properties and wide potential applications such as catalysis,

chemo-sensors, biomaterials, etc. In the past decades many researches have reported

the template synthesis of composite nanowires using anodized aluminum oxide,

porous polymer film or cylindrical polymer brushes, however, the resulted composite

nanowires in dispersion or powder exhibited the intrinsical disadvantages in

mechanical strength and processability, and that limited their further application. In

this work, we advocated a new strategy to produce the composite nanowires with

prominent stability and strength, for these nanowires could intertwine with each other,

builting a self-supporting network. Coordinated metallogels constituted of three

dimensional networks, including Ag(I) gel, Fe(III) gel and In(III) gel, were employed

as templates. These gels were all thermo-stable and easy to decompose after the

addition of competing ligands. Generally, a metallogel was prepared first, and then the

polymerization was in situ carried out using gel fibers as templates to produce

composite nanowires. The resulted nanowires were characterized by TEM and SEM,

wherein the polymer was coated on the outer layer, and gel fiber located in the inner

core. This morphology was formed by the template effect since the polymer/oligomer

in the solution was inclined to deposite on the nanofibers through van der Waals

forces. The product nanowires exhibited gel-like status as metallogel template, but

showed the enhanced mechnical strength. The inner metallogel template could be

directly removed by addition of ammonia to generate self-supporting nanotubes, also

it could be further employed as the precursor to produce self-supporting composite

nanowires with inorganic nanoparticles by post-treatment. Therefore, this versatile

and facile method may have applications in fabrication of various self-supporting

composite nanowires.



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P 5-1

Freeze and Heat-Resistant, Nonflammable and Highly Robust Ionic

Liquid-Based Click-Ionogels

Yongyuan Ren, Jiangna Guo, Ziyang Liu, Zhe Sun, Yiqing Wu, Lili Liu, Feng Yan*

（Department of Polymer Science and Engineering, College of Chemistry, Chemical Engineering

and Materials Science, Soochow University, Suzhou, 215123, China）


Gels that are freeze-resistant and heat-resistant having high ultimate tensile

strength are desirable in practical applications owing to their potential in designing

flexible energy-storage devices, actuators, and sensors. Here, a simple method for

fabricating ionic liquid (IL)-based click-ionogels using thiol-ene click chemistry

under mild condition is reported. These click-ionogels continue to exhibit excellent

mechanical properties and resilience, after ten thousand fatigue cycles. Moreover, due

to several unique properties of ILs, these click-ionogels exhibit high ionic

conductivity, transparency, and nonflammability performance over a wide

temperature range (-75 ℃ to 340 ℃). Remarkably, due to the outstanding properties

of the click ionogels, TENG using the gels as electrodes also displayed superior

mechanical stability and a wide operating temperature range. In combination with the

properties above, the click ionogels likely have promising applications for use in

extreme conditions in various electrical devices, such as flexible sensors, energy

storage devices, electronic skins, and wearable devices.

Keywords: Ionic liquids, Ionogels, Robust, Freeze/heat-resistant

References:

[1]. Ren YY.; Guo JN,; Liu ZY,; Sun S,; Wu YQ,; Liu LL,; Yan Y* (under

revision).



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163

P 5-2

Molecular dynamics simulation of rupture mechanism in nanofiller

filled polymer nanocomposites

Yangyang Gaoa, Liqun Zhanga*

a Center of Advanced Elastomer Materials. Beijing University of Chemical

Technology, Beijing, China.

Through coarse-grained molecular dynamics simulation, we aim to uncover the

rupture mechanism of the nanofiller filled polymer nanocomposites by characterizing

the structural and dynamic changes during the tension process. We find that the strain

at failure is corresponding to the coalescence of single void into larger voids, namely

the change of the free volume. And the minimum of the Van der Walls (VDWL)

energy reflects the maximum mobility of polymer chains and the largest number of

voids of polymer nanocomposites. After the failure, the stress gradually decreases

with the strain, accompanied by the contract of the highly orientated polymer bundles.

The number of voids is quantified as a function of the strain, exhibiting a

non-monotonic behavior because of the coalescence of small voids into larger ones at

high strain. However, the number of voids is greatly reduced by a stronger interfacial

interaction. In particular, with weak interfacial interaction, the nucleation of voids

occurs in the interface, and in the polymer matrix in the strong case. We

systematically study the effects of the interfacial interaction, temperature, the length

and volume fraction of nanofillers, chain length, bulk cross-linking density, interfacial

chemical bonds and grafted chains on the rupture behavior, such as the stress at failure,

the tensile modulus and the rupture energy. The rupture resistance ability increases

with the increase of the interfacial interaction, rod length, and bulk cross-linking

density. With the interfacial interaction increasing, it induces the rupture transition

from mode A (no bundles) to B (bundles).The transition point of the stress at failure as

a function of the temperature roughly corresponds to the glass transition temperature.

At longer chain length, a non-zero stress plateau occurs. And excessive chemical

bonds between polymer and nanofillers are harmful to the rupture property. We find

that an optimal volume fraction of nanofillers exists for the stress-strain behavior,

which can be rationalized by the formation of the strongest polymer-nanorod network,

leading to the slowest mobility of nanofillers. In addition, the rupture property first



June 14-17, 2019

164

increases and then decreases with the increase of the grafting density, which can

explained by the contribution of matrix chains, grafted chains, and nanofillers to the

total stress.

Keywords: Molecular dynamics simulation, polymer nanorod filled

nanocomposites, rupture.

*Corresponding Author: [email protected]

References:

1 Yangyang Gao, Liqun Zhang*, et al., Phys. Chem. Chem. Phys., 2014, 16,

18483-18492.

2 Yangyang Gao, Liqun Zhang*, et al., Phys. Chem. Chem. Phys., 2014, 16,

16039-16048.

3 Yangyang Gao, Liqun Zhang*, et al., Journal of Polymer Science Part B:

Polymer Physics. 2017, 55, 1005-1016.

4 Yangyang Gao, Liqun Zhang*, et al., Computational Materials Science. 2018,

142, 192-199.

5 Yangyang Gao*, Liqun Zhang*, et al., Composites Science and Technology.

2018, 167, 404-410.

6 Yangyang Gao, Liqun Zhang*, et al., RSC Advances. 2018, 8, 27786-27795.




June 14-17, 2019

165

P 5-3

Research and application of implantable blood detection device based

on shape memory polymer

Lanlan Liu, Bocheng Zhang, Zujun Peng, Ying Chen, Xue Feng‡‡‡‡‡‡‡‡‡‡‡‡‡‡‡

（Frontier Research Center, Institute of Flexible Electronics Technology of THU. Zhejiang,

No.906 Yatai Road, Jiaxing, Zhejiang, China）


The detection of blood in the aorta plays a guiding role in the prevention and

treatment of cardiovascular diseases. The detection of local blood in the diseased

vessels is a difficult subject in scientific research. This paper introduces a sensor for

local blood detection that can be combined with a cardiovascular stent. The sensor

uses shape memory polymer (SMP) as a flexible substrate. After the cardiovascular

stent enters the lesion site of human body, the device is deformed by external

conditions to complete the device deployment and fixation. The sensing unit endows

the interdigital electrode with unique stretching and bending characteristics through

the design of the serpentine wire. The detection sensitivity and detection limit of the

sensor can be adjusted by designing the number and length of the interdigital

electrode through electric field simulation. Finally, the blood detection device was

fabricated by 3D printing and several key blood parameters were tested, and the

accuracy of the device was evaluated.

Keywords: Implantable blood detection device, Shape memory polymer, 3D printing

References:

[1] Zhou C.; Hedayati MK.; Zhu XH.; Nielsen F.; Levy U.; Kristensen A*, ACS Sens.

2018, 3, 784.

[2] Wu JJ.; Huang LM.; Zhao Q.; Xie T*, Chinese J. Polym. Sci. 2018, 36, 563.

[3] Chen YH.; Lu SY.; Zhang SS.; Li Y.; Qu Z.; Chen Y.; Lu BW.; Wang XY.; Feng

X*, Sci. Adv. 2017, 3, e1701629.

This research was supported by the Natural Science Foundation of Zhejiang Province, China

(Grant No. Q19E030011).



June 14-17, 2019

166

P 5-4

Stretchable resistance sensor based on liquid metal direct writing

method

Bocheng Zhang, Lanlan Liu, Ruitao Tang, Qifeng Du, Ying Chen, Xue

Feng§§§§§§§§§§§§§§§

（Frontier Research Center, Institute of Flexible Electronics Technology of THU. Zhejiang,

No.906 Yatai Road, Jiaxing, Zhejiang, China）


With the development of flexible electronic technology, the combination of

liquid metal and micro-channel technology has been applied to the preparation of

interconnected structures, micro-fluid components and soft electrodes. It is a core

issue that adjusting the mechanical properties of flexible substrates enhance the

reliability and stability of liquid metal devices. In this project, we combined liquid

metal with direct writing technology to produce a stretchable resistance sensor which

could use on the wearable devices. The force distribution of the whole device during

tension is analyzed by mechanical simulation. According to the analysis results, we

optimized the shape of the device and the flow channel of the liquid metal. The

injection of liquid metal is accomplished by combining laser direct writing with

micro-channel technology. We analyzed the resistance change of liquid metal and the

physical state of liquid metal during tension, and explained the phenomenon that

resistance changes differently when liquid metals are filled and hollow.

Keywords: Stretchable resistance sensor, Liquid metal, Direct writing

References:

[1] Wang JX.; Cai GF.; Li SH.; Gao D.; Xiong JQ.; Lee PS*, Adv. Mater. 2018, 30,

1706157.

[2] Zhou XY.; Zhang RC.; Li LJ.; Zhang LJ.; Liu BX.; Deng ZS.; Wang LJ.; Gui Li*,

Lab Chip. 2019, 19, 807.

[3] Yang YQ.; Sun N.; Wen Z*.; Cheng P.; Zheng HC.; Shao HY.; Xia YJ.; Chen C.;

Lan HW.; Xie XK.; Zhou CJ.; Zhong J.; Sun X*.; , Lee ST*, ACS Nano 2018, 12, 2,

2027.

This research was supported by the Natural Science Foundation of Zhejiang Province, China

(Grant No. Q19E030011).



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167

P 5-5

Ionoprinting controlled information storage of fluorescent hydrogel

for hierarchical and multidimensional decryption

Xiao Xia Le1, Jia Wei Zhang1*, Tao Chen1*

（1Ningbo Institute of Material Technology and Engineering, Chinese Academy of Sciences,

Ningbo 315201, China）


Information storage and corresponding encryption/decryption are highly

important owing to the prevalence of counterfeit activities and information leakage in

the current age. Herein, we propose a novel method to store information via

controllable ionoprinting onto fluorescent hydrogel for hierarchical and

multi-dimensional decryption. Through incorporating pyrene moieties and carboxylic

groups into polymeric hydrogel network, fluorescence changing and controllable

shape deformation behaviors could be achieved and integrated by ionoprinting of Fe3+

ions. The diffusion of Fe3+ ions into fluorescent hydrogel can quench the fluorescence

of pyrene moieties, and chelate with carboxylic groups to generate anisotropic

structures for shape deformation simultaneously. Thus, fluorescence quenching-based

2D information and actuation-based 3D information could be hierarchically decrypted

when exposed to UV light and being put into water, respectively. Importantly, the

stored information could be erased by replacing Fe3+ with H+, which allows the

fluorescent hydrogel as a recyclable information storage material. This work may

provide new insights in designing and fabricating novel soft devices for hierarchical

and multidimensional information encryption, against the rising problems of

counterfeiting and confidential information disclosure.

Keywords: Information storage, Information decryption, Hydrogel actuator,

Fluorescence quenching, Anisotropic structures

References:

[1]. Le XX; Lu W; He J; Serpe MJ; Zhang JW*, Chen T*, Sci. China Mater. 2019,

62(6):831-839.

[2]. Le XX; Lu W; Zhang JW*; Chen T*, Adv. Sci. 2019, 6, 1801584.





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P 5-6

Multifunctional Wearable Sensors based on Repairable and

Recyclable Carbon Nanotubes Conductive Hydrogel

Haifei Wang, Jiameng Lu, Huayi Huang, Zhengchun Peng*

（Center for Stretchable Electronics and Nano Sensors, Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education, College

of Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, P. R. China）


Wearable electronic devices present booming development because of their

promising applications in fields including health monitoring, human-machine

interaction, consumer electronics and portable energy storage.[1] Conductive

hydrogels are a promising flexible electronic material due to its excellent mechanical

properties, high conductivity and good biocompatible.[2] However, inevitable

performance decaying of wearable devices is caused by dynamic deformation and

mechanical fatigue. We introduce novel repairable and recyclable conductive

hydrogels, which are prepared by covalent crosslinking poly(vinyl alcohol) (PVA)

and carbon nanotubes based on aldol reaction. The conductive hydrogels showed high

elastic property, good mechanical stability and excellent conductivity. By integrating

conductive hydrogel in wearable electronic devices, the wearable devices can be

repaired and fully recycled. We demonstrate high performance and multifunctional

wearable devices with capabilities on detection of finger gestures, radial artery and

electromyographic signal. As a candidate of flexible conductive materials, repairable

and recyclable conductive hydrogel show great potential on wearable devices and will

help to improve device stability and lifetime.

Keywords: Conductive hydrogel, Wearable sensor, Flexible electronic

References:

[1]. Zhang, Y.-Z.; Lee, K. H.; Anjum, D. H.; Sougrat, R.; Jiang, Q.; Kim, H.;

Alshareef, H. N.*, Sci. Adv. 2018, 4 (6), eaat0098.

[2]. Yuk, H.; Lu, B.; Zhao, X.*, Chem. Soc. Rev. 2019,48(6), 1642-1667.



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P 5-7

Autonomous swarming of biomolecular robots utilizing the

sequential signaling of DNA

Jakia Jannat Keya1, Arif Md. Rashedul Kabir1, Akinori Kuzuya2 and Akira Kakugo1,3

（1 Faculty of Science, Hokkaido University, Sapporo 060-0810, Japan ;2 Department of

Chemistry and Materials Engineering, Kansai University, Osaka 564-8680, Japan; 3Graduate

School of Chemical Sciences and Engineering, Hokkaido University, Sapporo 060-0810, Japan）


Nature constructs complex structures by self-assembly process to display

emergent functions. Swarming is a fascinating example of self-assembly of living

organisms into large scale structures offering several advantages. Although realizing

such behavior as the nature does always inspire scientists, mimicking such features

remained the biggest challenge. Recently we have demonstrated swarming of

molecular sized self-propelled objects such as natural biomolecular system

microtubule (MT)/kinesin powered by adenosine tri-phosphate (ATP) to construct

molecular swarm robots. DNA crosslinker complementary to the receptors can pair up

DNA tethered MTs to form swarms with both translational and rotational motion1,2.

However, to construct swarm robot, autonomous information transfer by the robots is

one of the essential criteria. Controlling the swarming of MTs by sequential DNA

input signal can further enhance the autonomous behavior of the robots. Such

information transfer exploration by MT swarm robots could offer applications in

diagnosis of analytes like miRNA and so on.

Keywords: Swarming, biomolecular system, DNA, swarm robot, autonomous

information transfer.

References:

[1]. Keya JJ.; Suzuki R.; Kabir AMR.; Inoue D.; Asanuma H.; Kazuki S.; Hess H.;

Kuzuya A.,* Kakugo A* Nat. Commun. 2018, 9:453

[2]. Keya JJ.; Kabir AMR.; Inoue D.; Kazuki S.; Hess H.; Kuzuya A.,* Kakugo A*

Sci. Rep. 2018, 8:11756

This work was supported by the National Natural Science Foundation of China (31300488).



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P 5-8

Super-elastic and multifunctional polymer hydrogel strengthened by

low-content cement-released nanoparticles

Guo Xing Sun1,2*, Rui Liang1, Xiao Sai Hu1, Xiao Xu Liang1, Hong Yao Ding1

（1 Joint Key Laboratory of the Ministry of Education, Institute of Applied Physics and Materials

Engineering, University of Macau, Avenida da Universidade, Taipa, Macau SAR, China. 2 Department of Physics and Chemistry, Faculty of Science and Technology, University of Macau,

Avenida da Universidade, Taipa, Macau SAR, China.）


Portland cements are innovatively used to obtain sub-5 nm particles. Such novel

cement-released nanoparticles pioneer super-elastic and multifunctional polymer

hydrogel, and drying-resistance oil gel. The calcium hydroxide nano-spherulites (CNS)

with diameters < 5 nm release from the surface of cement particles when cement

particles are dispersed in water at 0℃. A very low content of CNS can remarkably

strengthen and tough polymer hydrogels due to the small size effect of CNS. The

poly(acrylamide) (PAM)/ CNS hydrogel cross-linked by 40 ppm CNS can be

stretched to more than 100-times strain with a stress of more than 500 KPa. The poly

(acrylic acid) (PAA)/CNS super-adsorbent hydrogel enhanced by 200 ppm CNS

shows excellent adsorption capacity for the removal of methylene blue dye (2,100

mg/g). Furthermore, conductive polymer/CNS hydrogel possesses high electrical

conductivity (20,830 S/m) and can be stretched up to 1,076% strain, showing

potential application in flexible stretchable electronic devices.

Keywords: Gel, Calcium hydroxide nano-spherulites, Super-elastic, Multifunctional

References:

[1]. Sun GX.; Li ZJ*; Liang R.; Weng LT.; Zhang LN, Nat. Commun. 2016, 7, 12095.

[2]. Hu XS.; Liang, R.; Sun GX*, J Mater Chem A. 2018, 36, 17612.

This research was supported by Science and Technology Development Fund from Macau

(FDCT-078/2017/A2).


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