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The 3rd International Congress of the “International Prof. Dr.
Alireza Yalda Academic Foundation in Medical Sciences”
17-20 November 2012 Tehran, Iran.
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From dynamite to neurotransmission: the contribution of smooth muscle physiologists in discovery of the first gaseous transmitter
Ahmad Reza DehpourDept. of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, IranNovember 2012 Tehran
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Prof. Mohammad A. Alivand Khoyi
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Prof. JS Gillespie Sir J Vane
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•Gillespie JSBr J Pharmacol 1971 Oct; 43(2):430p
The rat anococcygeus: a new densely innervated smooth muscle preparation.
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Prof. Frank MichalAhmad R. Dehpour Prof. Gustav Born
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•Gillespie et al.
Br J Pharmacol 1989 Dec; 98(4):1080-2.
The effect of L-arginine and NG-monomethyl-arginine on the response of the rat anococcygeus muscle to NANC nerve stimulation.
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Ever since William Harvey described the circulation of
the blood, physiologists have realized that in sound
and living vessels the blood remains fluid, but it
coagulate in dead ones, (Ernst Bruke, 1857).
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Endothelium-derived relaxing factors• The vasoactivity of ACh had been an enigma for many years.
• In 1914, Dale found it to be vasodilator.
• In 1915, Hunt said it was vasoconstrictor.
• In 1951, Burn and his collegues found that it was vasodilator and
vasoconstrictor.
• In 1980, Furchgott and Zawadzki showed that the endothelial lining was
essential for the vasodilator action of ACh (Endothelium-dependent ACh-
induced relaxation).
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The endothelial cell as a metabolic and endocrine organ.
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• For decades, we have been discovering hormones and
meditiators based on complex organic molecules such as
peptides, amines, PGs and LTs.
• in 1987, it turns out that one of the most fascinating of them
all is a simple one-to-one combination of the main element of
the atmosphere.
• Pharmacology and Physiology (biological sciences) are full of
surprises.
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Dynamite cure Dynamite
Alfred R. Noble
Noble prizes Nitric oxide Alfered B. Noble
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Thanks For Your Attention
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Experimental NO Study