Thailand Researches in Microbiological Risk Assessment : Past & Present
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Thailand Researches in
Microbiological Risk Assessment
: Past & Present
Suphachai Nuanualsuw
anDVM, MPVM,
PhD
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Risk Analysis (Codex)
Risk communication
Risk
assessment
Riskmanagement
Suphachai
DVM, MPVM, PhD
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1. A process of systematic and objective
evaluation of all available information
pertaining to foodborne hazards.
2. This process identifies (& quantifies) the
risk.
Risk Assessment (RA)
Suphachai
DVM, MPVM, PhD
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1. The process of weighing policy alternatives
in the light of the result of risk assessment, if
required, and selecting and implementing
appropriate control option, including
regulatory measures.
2. This process controls or prevents the risk
Risk Management (RM)
Suphachai
DVM, MPVM, PhD
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1. The interactive exchange of information and
opinions concerning risks and risk
management among risk assessors, risk
managers, consumers, and other interested
parties.
2. This process informs others of the risk.
Risk Communication (RC)
Suphachai
DVM, MPVM, PhD
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Risk Analysis (CAC)
Risk communication
Risk
assessment
Riskmanagement
Suphachai
DVM, MPVM, PhD
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1. Hazard Identification (HI)
2. Hazard Characterization (HC)
3. Exposure Assessment (EA)
4. Risk Characterization (RC)
Risk Assessment
Suphachai
DVM, MPVM, PhD
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1 .การระบุ�อั�นตราย2. การอัธิ บุายอั�นตราย3. การประเมิ นการสั�มิผั�สั4. การอัธิ บุายความิเสั��ยง
ประเมิ นความิเสั��ยง
Suphachai
DVM, MPVM, PhD
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1. Hazard Identification
2.Hazard Characterization 3.Exposure
Assessment
4. Risk Characterization
Risk Assessment
Suphachai
DVM, MPVM, PhD
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The identification of biological, chemical, and
physical agents capable of causing adverse he
alth effects and which may be present in a part
icular food or group of foods.
1.Hazard Identification
Risk Assessment
Suphachai
DVM, MPVM, PhD
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The qualitative and/or quantitative evaluation
of the likely intake of biological, chemical, and
physical agents via food as well as exposures f
rom other sources if relevant.
3. Exposure Assessment
Suphachai
DVM, MPVM, PhD
Risk Assessment
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3. Exposure Assessment
Risk Assessment
• Probability of exposure
• Prevalence (%)
• Concentration (CFU/g or MPN/ml)
• Consumption (g/day)
• Dose (CFU or MPN)
Suphachai
DVM, MPVM, PhD
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Beta(63.000, 98.000) vsBeta(31.000, 52.000)
0
2
4
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0.2
5
0.3
0
0.3
5
0.4
0
0.4
5
0.5
0
0.5
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< >5.0% 5.0%90.0%0.3290 0.4552
Mean = 0.39130
Mean = 0.37349
3. Exposure Assessment
Risk Assessment
Probability of Exposure
Pro
bab
ility
den
sity
Suphachai
DVM, MPVM, PhD
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The qualitative and/or quantitative evaluation
of the nature of the adverse health effects ass
ociated with the hazard. For the purpose of Mic
robiological Risk Assessment the concerns rela
te to microorganisms and/or their toxins.
2. Hazard Characterization
Suphachai
DVM, MPVM, PhD
Risk Assessment
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2. Hazard Characterization
Risk Assessment
“ Dose-response assessment ” previously
Suphachai
DVM, MPVM, PhDDose
Resp
on
se
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The process of determining the qualitative and/or qu
antitative estimation, including attendant uncertainti
es, of the probability of occurrence and severity of kn
own or potential adverse health effects in a given po
pulation based on hazard identification, hazard char
acterization and exposure assessment.
4. Risk Characterization
Suphachai
DVM, MPVM, PhD
Risk Assessment
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0.1 0.25 0.4 0.55 0.7
5% 90% 5% .2863 .5225
Mean=0.4021729
Distribution of Probabilty of exposure
Re
lative
fre
que
ncy
Probability of exposure
0
1
2
3
4
5
6
Mean=0.4021729
0.1 0.25 0.4 0.55 0.7
4. Risk Characterization
Risk Assessment
Risk
Pro
bab
ility
den
sity
Suphachai
DVM, MPVM, PhD
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Year Host Risk Hazard Commodity PI
2545 ACFS EA VP Shrimp A.Orasa
2546 ACFS MRA Salmonella Chicken A.Sumontha
MRA C. jejuni Chicken A.Pravate
MRA VP Crab meat A.Pensri
2548 ACFS EA N/A Consumption A.Wongswat
MRA Projects : Past & Present
VP : V. parahaemolyticus PI : Principal investigatorSuphachai
DVM, MPVM, PhD
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Year Host Risk Hazard Commodity PI
2549 ACFS MRA L.monocytogenes Chicken Dr.Suphachai
BIOTEC MRA Staph. aureus Nham Muu Dr.Ruud
2551 BIOTEC MRA VP Shrimp Dr.Wrapa
BIOTEC MRA Salmonella Vegetable Dr.Wrapa
2552 BIOTEC HC Salmonella + VP N/A Dr.Suphachai
MRA Projects : Past & Present
VP : V. parahaemolyticus PI : Principal investigatorSuphachai
DVM, MPVM, PhD
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Research Categorization
Suphachai
DVM, MPVM, PhD
Risk analysis
Commodity&
Market
Application
Hazard
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Food safety objective (FSO) concept
Raw material Pasteurization Food Storage/Distribution Consumption Illness
Performance objective
Performance criteria Process criteria
Microbiological criteria Food safety objective (FSO)
Appropriate level of protection (ALOP)Cases / year
PO PO
Suphachai
DVM, MPVM, PhD
MRA
Risk management via Models
RISK ANALYSIS
Research Categorization
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HAZARD
• Bacteria
• Infection : Salm., VP., Campy., Cronobacter
• Intoxication : Staph.aureus, B.cereus,
Clostridium
• Viruses
• Norovirus (Norwalk, previously)
• Hepatitis A virus
• Hepatitis E virus
• Protozoa & ParasiteSuphachai
DVM, MPVM, PhD
Research Categorization
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Research Categorization
APPLICATION
• Risk estimate
• Setting Microbiological limit (ML)
• Setting Microbiological criteria (MC)
• Consumer protection (Thais)
• Domestic
• Import (in conjunction with Thai FDA)
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• Geography : Land, Sea
• Species : Animal, Plant
• Cook vs. Raw (RTE vs. export)
• Domestic vs. International markets
• Domestic : Locally made vs. Import
• International : Low end vs. Hi end (countries)
Suphachai
DVM, MPVM, PhD
Research Categorization
COMMODITY & MARKET
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Research Gap
CommodityH
aza
rdShrimp Chicken Pork Vegetable etc.
Salm
.
V
P.
C
am
py.
Vir
us
Suphachai
DVM, MPVM, PhD
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Research Gap
• MRA is only a snap shot info. (not realtime)
• Qualitative vs. Quantitative MRA
• Prioritized by
• Thai population
• risk estimate
• setting FSO
• setting MC
• Export or driven by food industriesSuphachai
DVM, MPVM, PhD
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Researcher Gap (Institutional perspective)
• Researchers
• Academia & Institutes (now)
• Graduate students (next)
• Trainings
• Collaboration & Communication
• Networking
• Information & Methodology
• Commitment
• FundingSuphachai
DVM, MPVM, PhD
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DVM, MPVM, PhD
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Thank you
for your attention
Welcome
Comments & Discussion
Suphachai
DVM, MPVM, PhD