Dr. Wonnop Visessanguan Executive Director

National Center of Genetic Engineering and Biotechnology (BIOTEC)

Thailand: Overview of the Biotechnology Sector and Strategy

to Develop Thailand's Bio-Economy

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8 June 2020. Dr. Suvit Maesincee, Minister of Higher Education, Science, Research and Innovation (MHESI) brought a team of eight top executives representing industries, entrepreneurs, academia, government agencies and people sector to meet Prime Minister General Prayut Chan-o-cha to discuss the use of Bio-Circular-Green Economic (BCG) Model to drive the national agendas which include food security, public health security, energy security, job security, environmental sustainability, as well as social inclusiveness. 2

Source: Ministry of Higher Education, Science, Research and Innovation

Food security

Health security

Energy security

Employment security

Environmental and natural resource security

Paradigm Shift: Modernization & Wealth Sustainability & Security

3

BCG Economy: A key global driver of economic development post COVID-19

Source: Ministry of Higher Education, Science, Research and Innovation

3 Guiding Principles

Strengthen from Within, Global Thai Linkage

Going Forward Together, Left No One Behind

Sufficiency Economy Philosophy (SEP) for Sustainable Development Goals (SDGs)

4

Food &

Agriculture Medical &

Wellness Energy &

Biochemical materials Tourism &

Creative Economy

INNOVATION

PRODUCTIVITY

Omics Bio-Materials

Bio-Energy Materials

Biomass Agro-based

Story-Telling

Biodiversity & Biotechnology

as drivers for

BCG economy

BCG Digital Platform

3.4 Trillion Baht

(21% GDP) 16.5 Million Employment

4.4 Trillion Baht

(24% GDP) 20 Million Employment

BCG MODEL: Aim for Distributive Economic Prosperity

Food &

Agriculture Medical &

Wellness Energy &

Biochemical

materials

Tourism &

Creative Economy

Biodiversity Cultural Diversity

5 Years

Precision

Medicine

Bioprocess

Biorefinery

High Value

Food Ingredients

Biosimilar, Herbal &

Medical Products

Bioactive Compound Digital Tourism

Management System

Geographical

Identification

High Value

Tourism High Value

Substance

High Value

Functional Food

Seeds/ Precision Farming

Healthy People

(Prediction/Prevention/Precision) Hygienic Kitchen of the World High Value-Added Products Happy destination

5

Source: Ministry of Higher Education, Science, Research and Innovation

Functional ingredients Functional foods 6

Source: Ministry of Higher Education, Science, Research and Innovation

Gene Therapy

Vaccine and Biosimilar

Medical Equipment

Clinical Research

Tele-Medicine

Herb Extraction For Medicine and Cosmetic Products

Genomic Data for Personalized Treatment

Thailand Medical Hub

7

Source: Ministry of Higher Education, Science, Research and Innovation

BCG MODEL in Energy, Material and Biochemical Sector

Agricultural Product and Waste

Investment Promotion

Industrial Development

8

Biotechnology and value creation in

biochemical industry

Within a year 3 years 5 years Source : Mitr Phol Group

9

Source: Ministry of Higher Education, Science, Research and Innovation

Tourism in Secondary

Cities and Communities

High Quality Tourism

Wellness Tourism

Standard For Tourism Sites

(Convenience / Clean / Safe)

Sustainable Tourism Standard System

National Guideline

for Tourism

Creative Cities and Creative Products

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Source: Ministry of Higher Education, Science, Research and Innovation

Publicly-led investment

Cash-aid policy

Annual funding

Individual project- based funding

Economic growth based on traditional industry

External-dependent growth

Individual contribution

Enterprise-led investment with government support

Government investment

Multi-year funding

Integrated project funding

New S-curve industry

Strengthening local economy and global linkage

Collective action through contribution of 4 sectors

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Paradigm shift

Paradigm shift

Now Then

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Content - Thailand biotechnology development policy - Agriculture and Food - Plant breeding development – Animal farming- Genetic engineering policy: Transgenic plants - disease diagnosis and services - Medicine and Health Medical devices - Diagnostic kits - Biopharmaceuticals – Stem cell technology - Vaccine - Biorefinery Industry - Bio Energy - Biomass - Biogas - Ethanol-Biodiesel - Bio Industry - Bioplastics - Why Thailand - Skilled labor - Access to markets - Attractive investment incentives - Development network of support organizations - National Science and Technology Development Agency (NSTDA) - National Center for Genetic Engineering and Biotechnology (BIOTEC) - Thailand Science Park (TSP) - National Biopharmaceutical Facility (NBF) - Research and development Certification Committee Secretariat(RDC) - Thailand Center of Excellence for Life Sciences (TCELS) - Thailand Instiute of Scientific and Technological Research (TISTR) - Biodiversity - Based Economy Development Office (BEDO) - The Venture Capital (VC) Industry in Thailand Link: http://aseanup.com/overview-biotechnology-thailand/

Overview of biotechnology in Thailand

Source: Ministry of Higher Education, Science, Research and Innovation

Collection, preservation and utilization

of bioresources

A collaborative human genome

research network to enable

precision medicine

Foster local economy

development

Improve agricultural

practice through precision

agriculture (TP Map/ Agrimap/ Hydro&Geo Map)

Scaling up technology:

Lab-scale to industrial–scale (Waste to Wealth

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collection

85,864 Microbial strains (bacteria/ fungi/ yeasts/ protists/ algae/ virus)

Thailand Bioresource Research Center

(TBRC)

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https://www.tbrcnetwork.org/

PLATFORMS

BCG MODEL

HEALTH &

MEDICAL

FOOD AND

AGRICULTURE

ENERGY AND

MATERIAL

TOURISM

THAI

BIORESOURCES

CATALOGUE

ECOSYSTEMS

PRECISION

MEDICINE IN

THAILAND

NBT FOR LONG-TERM CONSERVATION AND UTILIZATION

OF THAI BIORESOURCES

430 SAMPLES

• CROP VARIETIES

• HERBS

• WILD CROP SPECIES

• INDIGINOUS SPECIES

2,400 SAMPLES

200 PLANT SAMPLES

9,000 MICROBE SAMPLES

2,300 SAMPLES

BASIC SCREENING

FOR INDUSTRIAL

APPLICATIONS • ENZYME

• FATTY ACIDS

2,300 SAMPLES

HUMAN GENOME

Precision medicine • HUMAN GENOME

GENOMIC

DNA

BANK

HERBARIUM

DIGITAL

BANK

FUNGARIU

M

MICROBE

BANK

BIOBANKING STANDARDS

CORE

TECHNOLOGY

• CRYOPRESERVATION (SEED/ TISSUE)

• ADVANCED TAXONOMY (MALDI-TOF MS)

• ECOLOGICAL MODELLING

• BIOINFORMATICS AND DATA SCIENCE

DATA

TECHNOLOGY

• GENOTYPE/ PHENOTYPE ANALYSIS

• POPULATION ANALYSIS

• METAGENOMICS OF MICROBIOME

• AUTOMATED SAMPLE

STORAGE -20C/ -80C

• BIOTYPER/

MALDI-TOF MS

• HPC; HIGH

PERFORMANCE

COMPUTING

INFRA-

STRUCTURE • SEED GERMINATION

SCANALYZER

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TISSUE

BANK

SEED

BANK

160 SAMPLES • HERBS

150 SAMPLES

ONLINE DATABASE

ANALYTIC PLATFORM

• PLANT

• MICROBE

• ECOLOGY

National Biobank of Thailand

Genomics Thailand

5 Targeted Diseases • Rare diseases

• Cancer

• Non-communicable diseases

• Pharmacogenomics

1,175 Whole genome sequencing (WGS)

1,092 Whole exome sequencing (WES)

2,505 SNAP Array data

GOV / Private

Enterprise

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https://genomicsthailand.com/Genomic/about

National Omics Center

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Software

Park

Southern Science Park

Northern

Science Park

Northeastern

Science Park

High–speed Train &

Dual-track Railway

Lam-Chabang &

Map-Ta-Phut

Seaports

Industrial Estate

Development

U- Tapao

International Airport

EECi

Thailand’s Regional Science Parks & Eastern Economic Corridor of Innovation (EECi)

A Translational

Research Hub Bridging

Research & Investment

across Thailand

Thailand

Science Park

Universities/ Research Institutes

Regional Science Parks

Target Industries

Modern Agriculture & Adv. Biotechnology

Bio-Fuels & Bio-Chemicals

Automation, Robotics & Smart Electronics

Aviation & Aerospace

High Performance Battery & Modern

Transports

Medical Device Startups / SMEs LEs / MNCs

TRL: 1 2 3

Laboratory

Development

4 5 6

Scale-up, Demonstration,

Localization

7 8 9

USD 43 bil. Investment in EEC

(cumulative 5 year Projection)

EEC i

Smart City

Development

Source : EECi, NSTDA 18

https://www.eeci.or.th/th/

EECi Biorefinery Pilot Plant

Overall construction progress 34.39%

Non-GMP pilot plant 47.26% GMP pilot plant 57.43%

Joint venture: Bio Base Europe Pilot Plant

+ NSTDA

The National Science and Technology Development Board approved

the establishment of “Bio Base Asia Pilot Plant” to manage the biorefinery pilot plant

on May 25,2563.

Biorefinery Pilot Plant

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Innovative immunotherapeutic and next generation novel long-acting biologics

Business expertise in South East Asia and execution capacity

Thailand’s #1 cGMP capacity and CMC expertise

To be ASEAN’s No.1 R&D-based biotechnology company with manufacturing capabilities

Kingen Holdings Stakeholders

20 http://www.nbf.kmutt.ac.th/

• Thailand has already been prepared for new economy.

• BCG model is now fully activated and put in action by Thai government and key stakeholders to shape up a country after disruption by COVID-19.

• International partners and global network are considered as key enablers.

• With more experiences on new mechanisms and business models, we will move forward at higher speed.

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Conclusions

Biodiversity Human Capital Infrastructure

Thailand Southeast Asia's prime destination for biotechnology development

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Thank You

National Center for Genetic Engineering and Biotechnology (BIOTEC) 113 Paholyothin Rd., Khlong Nueng, Khlong Luang, Pathum Thani 12120 Thailand Tel:66 2564 6700 Fax:66 2564 6701 to 04

www.biotec.or.th

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