TESTOSURGE Uniqueness Backed by 2 Published Clinical ... · Over 3.5 lbs of muscle in 4 weeks*...

3
* These statements have not been evaluated by the FDA. These products/ingredients are not intended to diagnose, treat, cure, or prevent any disease or condition. Page 1 of 3 TESTOSURGE™ Uniqueness Backed by 2 Published Clinical Studies * Works on the Very First Dose * Once Per Day Dosing * Prevents Unwanted Side-Effects * Anti-Aromatase & 5 α-Reductase Inhibitor * Anti-Estrogen – Protecting Testosterone * Improves Body Composition * Highest Standardization of Glycosides * Approved Natural Health Product - Canada (NPN8007075) Competitive Advantages Increases Anabolic Hormone Status * Significantly Increases Testosterone Levels Increases Total Testosterone (TT) o 144% @ 4 weeks * , 146% @ 8 weeks * Increase Bio-available Testosterone (BT) o 209% @ 4 weeks * , 178% @ 8 weeks * Increases Free Testosterone (FT) 120% after 10h Significantly Improved Body Composition after 8 Weeks * Body Fat 2.2 Times Greater than Placebo * Greater Fat Loss * Acute Study: Total Testosterone 313% * , Bioavailable Testosterone 220% * 21% Increase in Strength * Highly Standardized Ingredient –for Accurate Dosing * Published Studies 1. Mokashi et al. (2014). Effects of glycosides based fenugreek seed extract on serum testosterone levels of healthy sedentary male subjects: an exploratory double blind, placebo-controlled, crossover study. Asian J of Pharmaceutical and Clinical Research. 7(2):177-181. 2. Wilbon et al. (2010). Effects of a purported aromatase and 5-alpha reductase inhibitor on hormone profiles in college-age men. IJSNEM. 20(6): 457-465 3. Poole et al. (2009). Effects of TESTOSURGE Supplementation on Strength, Body Composition and Hormonal Profiles during an 8-Week Resistance Training Program. JISSN. 6(Suppl1):P12 Comparison to Common Testosterone Ingredients TESTOSURGE™ (vs. placebo) Competitor 1 Competitor 2 Competitor 3 Dosing Once per day 2x per day Once per day 2x per day Increases in Total Testosterone 144% @ 4 weeks * 146% @ 8 weeks * 313% @10 hours * (acute study) Not Significant Yes (42%) * (vs. placebo) Yes * (vs. placebo) Increases in Free Testosterone 209% @ 4 weeks * 178% @ 8 weeks * 120% @10 hours * (acute study) 98% * (vs. baseline) 68% * (vs. placebo) Not Measured Not Measured Acute effects (after 10 hours) Total Testosterone 313% * Free Testosterone 120% * Bioavailable Testosterone 220% * Unknown Unknown Unknown Reduction in fat loss 224% * 30% * No No Aromatase & 5 α- reductase Inhibition Yes Unknown Unknown Unknown

Transcript of TESTOSURGE Uniqueness Backed by 2 Published Clinical ... · Over 3.5 lbs of muscle in 4 weeks*...

Page 1: TESTOSURGE Uniqueness Backed by 2 Published Clinical ... · Over 3.5 lbs of muscle in 4 weeks* BIOCREAT Therapeutic Dose 900 mg + 3.5 g creatine (Taylor et al. 2011) Increases in

*These statements have not been evaluated by the FDA. These products/ingredients are not intended to diagnose, treat, cure, or prevent any disease

or condition. Page 1 of 3

TESTOSURGE™

Uniqueness • Backed by 2 Published Clinical Studies*

• Works on the Very First Dose* • Once Per Day Dosing* • Prevents Unwanted Side-Effects*

• Anti-Aromatase & 5 α-Reductase Inhibitor*

• Anti-Estrogen – Protecting Testosterone*

• Improves Body Composition* • Highest Standardization of Glycosides* • Approved Natural Health Product - Canada (NPN8007075)

Competitive Advantages

• Increases Anabolic Hormone Status* • Significantly Increases Testosterone Levels • Increases Total Testosterone (TT)

o 144% @ 4 weeks*, 146% @ 8 weeks* • Increase Bio-available Testosterone (BT)

o 209% @ 4 weeks*, 178% @ 8 weeks* • Increases Free Testosterone (FT) 120% after 10h • Significantly Improved Body Composition after 8 Weeks* • Body Fat 2.2 Times Greater than Placebo* • Greater Fat Loss* • Acute Study: Total Testosterone 313%*, Bioavailable Testosterone 220%* • 21% Increase in Strength* • Highly Standardized Ingredient –for Accurate Dosing*

Published Studies 1. Mokashi et al. (2014). Effects of glycosides based fenugreek seed extract on serum testosterone levels

of healthy sedentary male subjects: an exploratory double blind, placebo-controlled, crossover study. Asian J of Pharmaceutical and Clinical Research. 7(2):177-181.

2. Wilbon et al. (2010). Effects of a purported aromatase and 5-alpha reductase inhibitor on hormone profiles in college-age men. IJSNEM. 20(6): 457-465

3. Poole et al. (2009). Effects of TESTOSURGE Supplementation on Strength, Body Composition and Hormonal Profiles during an 8-Week Resistance Training Program. JISSN. 6(Suppl1):P12

Comparison to Common Testosterone Ingredients

TESTOSURGE™ (vs. placebo) Competitor 1 Competitor 2 Competitor 3

Dosing Once per day 2x per day Once per day 2x per day

Increases in Total Testosterone

144% @ 4 weeks* 146% @ 8 weeks*

313% @10 hours* (acute study) Not Significant Yes (42%)*

(vs. placebo) Yes *

(vs. placebo)

Increases in Free Testosterone

209% @ 4 weeks* 178% @ 8 weeks* 120% @10 hours * (acute study)

98%* (vs. baseline) 68%* (vs. placebo)

Not Measured

Not Measured

Acute effects (after 10 hours)

Total Testosterone 313%* Free Testosterone 120%* Bioavailable Testosterone 220%*

Unknown Unknown Unknown

Reduction in fat loss 224%* 30%* No No

Aromatase & 5 α-reductase Inhibition

Yes Unknown Unknown Unknown

Page 2: TESTOSURGE Uniqueness Backed by 2 Published Clinical ... · Over 3.5 lbs of muscle in 4 weeks* BIOCREAT Therapeutic Dose 900 mg + 3.5 g creatine (Taylor et al. 2011) Increases in

*These statements have not been evaluated by the FDA. These products/ingredients are not intended to diagnose, treat, cure, or prevent any disease

or condition. Page 2 of 3

BIOCREAT™

Potential Product Categories

• Creatine Category • Anabolic Muscle Builder • Weight Requirement Sports • Muscle Gainer

• Strength Builder • Hardcore/Extreme Sports • Recovery • Low Carbohydrate Category

Uniqueness • NEW – Double Potent Version Available • Enhances Creatine Efficiency (3.5g vs. 5g) * • Benefits of Creatine Without the Sugar* • Eliminates the Requirement of Carbohydrate for Creatine Delivery • Clinically Proven in a University Study • Evaluated Head-to-Head vs. Creatine + CHOs (sugar) • Outperformed Creatine + CHOs for Increasing Power after 4 Weeks* • Alternative Method to Ingesting High Doses of Carbohydrates + Creatine*

Competitive Advantages

• No Sugar, No Loading, No Bloating, No Crash * • Outperformed Traditional Creatine Dosing (Creatine + Sugar) * • Increases Power 370% in 4 Weeks* • 2.4 Times Greater Increase in Lean Body Mass* • Significantly Increases Strength 120%* • Unique Standardized Ingredient – for Accurate Dosing* • Stackable with other Product Categories

Published Studies

1. Taylor et al. 2011. Effects of combined creatine plus fenugreek extract vs. creatine plus carbohydrate supplementation on resistance training adaptations. J Sports Science Med. 10:254-260

2. Lewing et al. (2009). Effects of BIOCREAT Supplementation on Strength and Body Composition During an 8-week Resistance Training Program. JISSN. 6(Suppl 1): P11

Potential Marketing Statements

Maintenance of high power output* Significantly impact strength and body composition* Significant muscular adaptations with supplementation* Significantly increase weight and lean body mass* Over 3.5 lbs of muscle in 4 weeks*

BIOCREAT Therapeutic Dose 900 mg + 3.5 g creatine (Taylor et al. 2011)

Increases in Strength 1.2 times or 120% greater increase in bench press*

Increase in Weight Significant increase in weight after 4 weeks*

Increase in lean body

mass

7 times or 700% @ 4 weeks*

2.4 times or 240% @ 8 weeks*

Increase in Peak Power 3.7 times or 370% increase in peak power 4 weeks*

Page 3: TESTOSURGE Uniqueness Backed by 2 Published Clinical ... · Over 3.5 lbs of muscle in 4 weeks* BIOCREAT Therapeutic Dose 900 mg + 3.5 g creatine (Taylor et al. 2011) Increases in

*These statements have not been evaluated by the FDA. These products/ingredients are not intended to diagnose, treat, cure, or prevent any disease

or condition. Page 3 of 3

HYPEROX™

Potential Product Categories

• Pre-Workout • Nitric Oxide (NO) -Pump

Products

• Men’s Health • Libido Products

Uniqueness • New Ingredient in the Nitric Oxide Category* • Novel Mechanism for Increasing Nitric Oxide * • Increases Vasodilation* • Increases Second Messenger Pathways*

Competitive Advantages

• Feel it After the First Dose* • Accelerates Nutrient Delivery and Blood Flow* • Extends the Nitric Oxide Signal* • Enzyme Inhibitor Leading to Powerful Prolonged Pumps*

Studies 1. In Vitro Study –Phosphodiesterase type 5 (PDE5) Enzyme Inhibition 2. In Vivo Study – Vasodilator Activity

3. Clinical Study Pending – To be completed Q1-Q2 2017 RATIONALE: Phosphodiesterase Enzyme-5 Phosphodiesterases (PDEs) are the key enzymes in multiple biochemical signaling pathways of the body and belongs to a superfamily of enzyme divided into 11 families (PDE1-PDE11). These enzymes catalyze the degradation of the secondary messengers, cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) to their respective monophosphate forms. These PDEs differs with respective to selectivity for cyclic nucleotides, physiological roles and tissue distribution. PDE5, a cGMP-specific PDE is highly expressed in the tissues like lung, platelets, neuronal cells, vascular, and smooth muscles. PDE5 has a crucial role in the metabolism of cGMP. Phosphodiesterase type 5 (PDE5) enzyme inhibitory effect

o HYPEROX blocks the degradative activity of PDE5 on secondary messenger cGMP in the smooth muscle cells and therefore enhances the action of vasodilation by increasing duration of action of cGMP*

o This activity demonstrates that it enhances the natural physiological process of NO cycle. This increases vasodilation leading to improved blood flow in muscle cells*

Endothelial nitric oxide synthase (eNOS) enzyme assay

o PDE5 inhibition does not interfere with the synthesis of endothelial nitric oxide synthase (eNOS) enzyme, which is an enzyme that generates basal release of NO in blood vessels and activates cGMP, which induces smooth muscle relaxation by dilating blood vessels*

o This action also demonstrates that HYPEROX is capable in regulating basal release of NO synthesis by protecting eNOS activity*

Figure 1: Phosphodiesterase enzyme inhibitory effect

TESTOSURGE™, BIOCREAT™, HYPEROX™ are registered trademarks of Indus Biotech.