Technetium-99m-MRP20, a Potential Brain Perfusion JN...

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Volume 32, Number 3 • March 1991 JNM Official Publication of The Society of Nuclear Medicine SNM NEWSLINE 11N U.S. and IAEA Chernobyl Delegations Assess Radiation Effects Joan Hiam 17N DOE Approves Grant for NBTF Feasibility Study Mash R. Ghosh 21N NRC Advisory Committee Calls for Narrowed QA Rule and Better-Defined Response to the Radiopharmacy Petition Sarah M. Ttlyou 25N Commentary: Lines from the President: The Future of Nuclear Medicine: SNM's Role Naomi P. Alazraki 30N News Briefs: Nordion's Main Medical Radionuclide Reactor Shuts Down; SNM to Hold Administrators' Day Program; Geologic Study Supports Suitability of Yucca Mountain Site; Nuclear Medicine Week Update HUMAN STUDIES 369 Dypyridamole Technetium-99m-2-Methoxy Isobutyl Isonitrile Tomoscintigraphic Imaging for Identifying Diseased Coronary Vessels: Comparison with Thallium-201 Stress-Rest Study vessels: Comparison with Thallium-201 Stress-Rest Study Flavio Tartagni, Maurizio Dondi, Patrizia Limonetii, Roberto Franchi, Luigi Maiello, Nino Monetti, and Bruno Magnani 377 Linear Gastric Emptying of Hyperosmolar Glucose Solutions William T. Phillips, Joyce G. Schwartz, Ralph Blumhardt, and C Alex McMahan 382 rCBF-SPECT in Brain Infarction: When Does It Predict Outcome? Martien Limburg, Eric A. Van Royen, Albert Hijdra, and Bernard Verbeeten, Jr. 388 Technetium-99m-HMPAO Brain SPECT in Medically Intractable Temporal Lobe Epilepsy: A Postoperative Evaluation Frank Griinwald. Herbert F. Durwen, Andreas Bockisch, Andreas Hotze, Wilhelm Kersjes, Christian E. Elger, and Hans J. Biersack 395 Thyroglobulin Level as a Predictive Factor of Tumoral Recurrence in Differentiated Thyroid Cancer Javier Ruiz-Garcia, J. Mariano Ruiz de Almodbvar, Nicholas Olea, and Vicente Pedraza 399 Technetium-99m-MRP20, a Potential Brain Perfusion Agent: In Vivo Biodistribution and SPECT Studies in Normal Male Volunteers Alex Bossuyt, Gillian F. Morgan, Marcel Deblaton, Robert Pirotte, Antonio Chirico, Pierre Clemens, Paul Vandenbroeck, and John R. Thornback 404 Combined Technetium Radioisotope Penile Plethysmosgraphy and Xenon Washout: A Technique for Evaluating Corpora Cavernosal Inflow and Outflow During Early Tumescence Alan N. Schwartz and Michael M. Graham 411 Optimal lodine-131 Dose for Eliminating Hyperthyroidism in Graves' Disease Robert A. Nordyke and Fred I. Gilbert, Jr. 417 Lung Thallium-201 Uptake During Exercise Emission Computed Tomography Chinori Kurata, Kei Tawahara, Takahisa Taguchi, Kuzuyuki Sakata, Noboru Yamazaki, and Ydsutsugu Naitoh 424 Use of Technetium-99m-MAG 3 for Renal Scintigraphy After Angiotensin-Converting Enzyme Inhibition Maurizio Dondi, Nino Monetti, Stefano Fanti, Fausto Marchetta, Claudio Corbelli, Paolo Zagni, Arcangelo De Fabritis, Franco Losinno, Maurizio Levorato, and Alessandro Zuccala 429 Relative Accuracy of Three Scintigraphic Methods for Determination of Right Ventricular Ejection Fraction: A Correlative Study with Ultrafast Computed Tomography Karim Rezai, Robert Weiss, William Stanford, Janice Perslar, Melvin Marcus, and Peter Kirchner 436 Proposal of a Modified Scintigraphic Method to Evaluate Duodenogastroesophageal Reflux Nicoletta Borsato, Luigi Bonavina, Pierluigi Zanco, Biagia Saitta, Franca Shierchetti, Alberto Perracchis, and Georgio Ferlin 441 Thallium-201 Scintigraphy in Differentiated Thyroid Cancer: Comparison with Radioiodine Scintigraphy and Serum Thyroglobulin Determinations Lalitha Ramanna, Alan Waxman, and Glenn Braunstein 447 Comparison of Myocardial Imaging with lodine-123- lodophenyl-9-Methyl Pentadecanoic Acid and Thallium-201-Chloride for Assessment of Patients with Exercise-Induced Myocardial Ischemia Pierre Chouraqui, Jamshid Maddahi, Robert Henkin, Stephen M. Karesh, Elizabeth Galie, and Daniel S. Berman LABORATORY STUDIES 453 Endotoxin Reduces Specific Pulmonary Uptake of Radiolabeled Monoclonal Antibody to Angiotensin- Converting Enzyme Vladimir R. Muzykantov, Elena A. Puchnina, Elena N. Atochina, Holger Hiemish, Mikhail A. Slinkin, Felix E. Meertsuk, and Sergei M. Danilov 461 Rapid Localization of lndium-111-Labeied Inhibited Recombinant Tissue Plasminogen Activator in a Rabbit Thrombosis Model S. Patrick Butler, KimbaHy L. Kader, John Owen, Theodore S.T. Wing, RashidA. Fawwaz, and Philip O. Alderson

Transcript of Technetium-99m-MRP20, a Potential Brain Perfusion JN...

Page 1: Technetium-99m-MRP20, a Potential Brain Perfusion JN ...jnm.snmjournals.org/content/32/3.toc.pdfJavier Ruiz-Garcia, J. Mariano Ruiz de Almodbvar, Nicholas Olea, and Vicente Pedraza

Volume 32, Number 3 • March 1991

JNM Official Publication of The Society of Nuclear Medicine

SNM NEWSLINE 11N U.S. and IAEA Chernobyl Delegations Assess

Radiation Effects Joan Hiam

17N DOE Approves Grant for NBTF Feasibility Study Mash R. Ghosh

21N NRC Advisory Committee Calls for Narrowed QA Rule and Better-Defined Response to the Radiopharmacy Petition Sarah M. Ttlyou

25N Commentary: Lines from the President: The Future of Nuclear Medicine: SNM's Role Naomi P. Alazraki

30N News Briefs: Nordion's Main Medical Radionuclide Reactor Shuts Down; SNM to Hold Administrators' Day Program; Geologic Study Supports Suitability of Yucca Mountain Site; Nuclear Medicine Week Update

HUMAN STUDIES 369 Dypyridamole Technetium-99m-2-Methoxy Isobutyl

Isonitrile Tomoscintigraphic Imaging for Identifying Diseased Coronary Vessels: Comparison with Thallium-201 Stress-Rest Study vessels: Comparison with Thallium-201 Stress-Rest Study Flavio Tartagni, Maurizio Dondi, Patrizia Limonetii, Roberto Franchi, Luigi Maiello, Nino Monetti, and Bruno Magnani

377 Linear Gastric Emptying of Hyperosmolar Glucose Solutions William T. Phillips, Joyce G. Schwartz, Ralph Blumhardt, and C Alex McMahan

382 rCBF-SPECT in Brain Infarction: When Does It Predict Outcome? Martien Limburg, Eric A. Van Royen, Albert Hijdra, and Bernard Verbeeten, Jr.

388 Technetium-99m-HMPAO Brain SPECT in Medically Intractable Temporal Lobe Epilepsy: A Postoperative Evaluation Frank Griinwald. Herbert F. Durwen, Andreas Bockisch, Andreas Hotze, Wilhelm Kersjes, Christian E. Elger, and Hans J. Biersack

395 Thyroglobulin Level as a Predictive Factor of Tumoral Recurrence in Differentiated Thyroid Cancer Javier Ruiz-Garcia, J. Mariano Ruiz de Almodbvar, Nicholas Olea, and Vicente Pedraza

399 Technetium-99m-MRP20, a Potential Brain Perfusion Agent: In Vivo Biodistribution and SPECT Studies in Normal Male Volunteers Alex Bossuyt, Gillian F. Morgan, Marcel Deblaton, Robert Pirotte, Antonio Chirico, Pierre Clemens, Paul Vandenbroeck, and John R. Thornback

404 Combined Technetium Radioisotope Penile Plethysmosgraphy and Xenon Washout: A Technique for Evaluating Corpora Cavernosal Inflow and Outflow During Early Tumescence Alan N. Schwartz and Michael M. Graham

411 Optimal lodine-131 Dose for Eliminating Hyperthyroidism in Graves' Disease Robert A. Nordyke and Fred I. Gilbert, Jr.

417 Lung Thallium-201 Uptake During Exercise Emission Computed Tomography Chinori Kurata, Kei Tawahara, Takahisa Taguchi, Kuzuyuki Sakata, Noboru Yamazaki, and Ydsutsugu Naitoh

424 Use of Technetium-99m-MAG3 for Renal Scintigraphy After Angiotensin-Converting Enzyme Inhibition Maurizio Dondi, Nino Monetti, Stefano Fanti, Fausto Marchetta, Claudio Corbelli, Paolo Zagni, Arcangelo De Fabritis, Franco Losinno, Maurizio Levorato, and Alessandro Zuccala

429 Relative Accuracy of Three Scintigraphic Methods for Determination of Right Ventricular Ejection Fraction: A Correlative Study with Ultrafast Computed Tomography Karim Rezai, Robert Weiss, William Stanford, Janice Perslar, Melvin Marcus, and Peter Kirchner

436 Proposal of a Modified Scintigraphic Method to Evaluate Duodenogastroesophageal Reflux Nicoletta Borsato, Luigi Bonavina, Pierluigi Zanco, Biagia Saitta, Franca Shierchetti, Alberto Perracchis, and Georgio Ferlin

441 Thallium-201 Scintigraphy in Differentiated Thyroid Cancer: Comparison with Radioiodine Scintigraphy and Serum Thyroglobulin Determinations Lalitha Ramanna, Alan Waxman, and Glenn Braunstein

447 Comparison of Myocardial Imaging with lodine-123-lodophenyl-9-Methyl Pentadecanoic Acid and Thallium-201-Chloride for Assessment of Patients with Exercise-Induced Myocardial Ischemia Pierre Chouraqui, Jamshid Maddahi, Robert Henkin, Stephen M. Karesh, Elizabeth Galie, and Daniel S. Berman

LABORATORY STUDIES 453 Endotoxin Reduces Specific Pulmonary Uptake of

Radiolabeled Monoclonal Antibody to Angiotensin-Converting Enzyme Vladimir R. Muzykantov, Elena A. Puchnina, Elena N. Atochina, Holger Hiemish, Mikhail A. Slinkin, Felix E. Meertsuk, and Sergei M. Danilov

461 Rapid Localization of lndium-111-Labeied Inhibited Recombinant Tissue Plasminogen Activator in a Rabbit Thrombosis Model S. Patrick Butler, KimbaHy L. Kader, John Owen, Theodore S.T. Wing, RashidA. Fawwaz, and Philip O. Alderson

Page 2: Technetium-99m-MRP20, a Potential Brain Perfusion JN ...jnm.snmjournals.org/content/32/3.toc.pdfJavier Ruiz-Garcia, J. Mariano Ruiz de Almodbvar, Nicholas Olea, and Vicente Pedraza

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Detection of a Local Staphylococcal Infection in Mice with Techrtetium-99m-Labeled Polyclonal Human Immunoglobulin Wim Calame, Hans l.J. Feitsma, Geert J. Ensing, Wim Th, Goedemans, Jan A. J. Camps, Ralph van Furth, and Ernest K.J. Pauwels

In Vivo Comparison of Copper Blood-Pool Agents: Potential Radiopharmaceuticals for Use with Copper-62 Carta J. Mathias, Michael J. Welch, Mark A. Green, Habibe Diril, Claude F. Meares, Robert J. Gropler, and Steven R. Bergmann

Editorial: Cardiac Blood-Pool Tracers Kalyani M. Subramanian

Imaging Focal Sites of Bacterial Infection in Rats with lndium-111-Labeled Chemotactic Peptide Analogs Alan J. Fischman, Marilyn C. Pike, Daniel Kroon, Anthony J. Fucello, Douglas Rexinger, Caroline tenKate, Robert Wilkinson, Robert H. Rubin, and H. William Strauss

Editorial: Chemotactic Peptides: New Locomotion for Imaging of Infection? Frans H.M. Corstens and Jos W.M. van der Meer

Cellular Internalization, Transport, and Esterification of lodine-125-NP59 by MA-10 Leydig Tumor Cells Dale A. Freeman and Raymond E. Counsell

Technetium-99m-MRP20, a Potential Brain Perfusion Agent: In Vivo Biodistribution and SPECT Studies in Non-Primate Animals Gillian F. Morgan, Marcel Deblaton, Pierre Clemens, Paul Van Den Broeck, Axel Bossuyt, and John R. Thornback

Differences in the Intracellular Processing of the Radiolabei Following the Uptake of lodine-125- and Technetium-99m-Neogalactosyl Albumin by the Isolated Perfused Rat Liver Stephen Gore, Anthony I. Morris, Ian T. Gilmore, Paul J. Maltby, John R. Thornback, and David Billington

CLINICOPATHOLOGIC CONFERENCES A Case of "False-Positive" High Probability Ventilation-Perfusion Lung Scan Due to Tuberculous Mediastinal Adenopathy with a Discussion of Other Causes of "False-Positive" High Probability Ventilation-Perfusion Lung Scans Harold I. Palevsky, Libby Cone, and Abass Alavi

CASE REPORTS Incidental Demonstration of Pericardial Fistula During Hepatobiliary Scintigraphy Susan W. Marlatt, Vicente J. Caride, and Edward K. Prokop

Gallium-67 Imaging in Retroperitoneal Fibrosis: Significance of a Negative Result Arnold F. Jacobson

524 Absent Splenic Uptake of lndium-111-Oxine-Labeled Autologous Leukocytes in Functional Asplenia Rodney J. Hicks, William Young, Brahm Shapiro, and David E. Kuhl

.: Dtiftt (hli;iuti^.!luMi.'4M

<-f«*-C - f t - £J>3 Z'-fSS, • " ' V?* * # ,V. « ft?

METHODOLOGY 527 Quantitative SPECT Reconstruction of lodine-123

Data David R. Gilland, Ronald J. Jaszczak, Kim L, Greer, R. Edward Coleman

CONTINUING EDUCATION 534 Three-Dimensional Display in Nuclear Medicine and

Radiology Jerold W. Willis and Tom R. Miller

DEPARTMENTS

446 Self-Study Test

467 15/30

547 Letters to the Editor

Book Reviews 556 Magnetic Resonance Imaging of the Pediatric Brain:

An Anatomical Atlas Reviewed by Roy D. Strand

556 Radiology of the Liver, Biliary Tract, Pancreas and Spleen Reviewed by Thomas Egglin

556 MRI of the Musculoskeletal System

Reviewed by Felix S. Chew

35A Calendar

41A Classified Advertising

46A Technologist Job Network

56A New Products

58A Index to Advertisers